EX-10.13



 Exhibit 10.13 

LEASE AGREEMENT 

THIS LEASE AGREEMENT (“Lease”) made as of this 1st day of August, 2013 between the University
of North Texas Health Science Center at Fort Worth, a state institution of higher education, hereinafter referred to as “Landlord”, and ZS Pharma, Inc. having a business address at 508 Wrangler Drive, Suite 100 Coppell, Texas 75019,
hereinafter referred to as “Tenant”. 
 WHEREAS, Tenant is a participant in UNTHSC’s Acceleration Lab Technology Commercialization
Program and desires to lease certain space from Landlord, all as hereinafter set forth; 
 WHEREAS, Landlord has agreed to do so under the terms and
conditions hereinafter set forth; and 
 WHEREAS, Landlord’s obligations to Tenant are set out in this Lease, and Tenant does not have any
additional rights to the Premises which are not expressly set forth herein. 
 NOW THEREFORE, the parties hereto mutually covenant and agree as
follows: 
  

	1.	Premises Description 

 Landlord does hereby lease to Tenant, and Tenant does hereby lease
from Landlord, that certain space which is situated on the 2nd floor of the Center for BioHealth building located at 3400 Camp Bowie Blvd., Fort Worth, Texas, and described as laboratory space in
room number 203 (large lab) which will be assigned to the Tenant, hereinafter referred to as “Premises”. 
  

	2.	Term and Termination 

 The term of this Lease shall be for twelve (12) months
commencing on August 1, 2013 (“Effective Date”) and ending on July 31, 2014 (“Term”). 
 Either party may
terminate this Lease at its option, without cause or penalty, by giving the other party thirty (30) days’ prior written notice of termination. In the event of notice of early termination, Tenant must vacate and surrender the Premises to
Landlord when or before the 30 day period expires. 
 If Tenant ceases to be a participant in UNTHSC’s Acceleration Lab Technology
Commercialization Program, Landlord may terminate this Lease immediately upon written notice to Tenant and upon receipt of such notice Tenant must vacate and surrender the Premises to Landlord. 

 

	3.	Rent 

 Tenant agrees to and shall pay to Landlord, as rent for the Premises, in equal
quarterly installments of $1,500 each in advance on the first day of each quarter commencing on the Effective Date. 
 The Tenant shall
ensure all quarterly installments, as detailed above, are submitted within the time frame noted to the following payment address: 

University of North Texas Health Science Center at Fort Worth 

3500 Camp Bowie Blvd., CBH-207 

Fort Worth, Texas 76107-2699 

Attn: Technology Transfer & Commercialization Office 

  
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	4.	Use 

 Tenant shall use and occupy the Premises for the purpose of a research lab and/or
office space and for no other purposes except those authorized in writing by Landlord, which authority shall not be unreasonably withheld, delayed or conditioned provided that such purposes are related to the research lab and office space and in
conformity with Landlord’s campus operations. 
 In the event Tenant fails to use the Premises as a research lab or office space or such
other related purpose, as approved by the Landlord for a period of thirty (30) days, then this event of the non-use of the Premises will be deemed to be a material default and this Lease may be terminated pursuant to Section 16 herein.

 Tenant has and will maintain any and all licenses and/or permits necessary to use and occupy the Premises for the purposes indicated
herein, and Tenant shall comply with all applicable laws and regulations and all applicable Landlord policies and procedures in Tenant’s use of and activities on the Premises. 

 

	5.	Utilities and Taxes 

 Landlord shall pay all charges for custodial, maintenance, water,
electricity and gas furnished to the Premises. Tenant shall be responsible for all other utility services provided to the Premises, including long distance telephone charges, unless otherwise agreed to by the parties. 

The Tenant shall be responsible for all real estate and/or property taxes, or payments in lieu thereof, arising from the Tenant’s use of
the Premises pursuant to this Lease and all special assessments levied against and/or attributable to the Premises during the period of this Lease as they shall become due. Tenant shall further pay all taxes, assessments and changes that may be
assessed and levied upon any improvements erected on the Premises by Tenant as they shall become due. 
  

	6.	Alterations, Additions, Installations and Removal Thereof 

 Tenant may, at its own
expense, either at the Effective Date of or during the term of this Lease, make such alterations in and/or additions to the Premises as may be necessary to fit the same for its business, upon first obtaining the written approval of Landlord as to
the materials to be used and the manner of making such alterations and/or additions. Landlord covenants not to unreasonably withhold, condition or delay its prior written approval of alterations and/or additions proposed to be made by Tenant. At any
time prior to the expiration or earlier termination of this Lease, Tenant may remove any or all such alterations, additions or installations in such a manner as will not substantially injure the Premises, or the portion or portions affected by such
removal, ordinary wear and tear, damage or destruction by fire, flood, storm, civil commotion, or other unavoidable cause excepted. All alterations, additions, or installations not so removed by Tenant shall become the property of Landlord without
liability on Landlord’s part to pay for the same. Tenant shall consult with Landlord prior to removing any alterations, additions or installations to ensure that such removal will not substantially injure the Premises, and said removal shall
not take place until the parties are in agreement regarding the method and manner of removal. 
 All alterations, additions, or installations
not so removed by Tenant prior to the termination of the Lease shall become the property of Landlord without liability on Landlord’s part to pay for the same. 

  
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	7.	Trade Fixtures, Personal Property 

 All articles of personal property and all business
and trade fixtures, machinery and equipment, furniture and movable partitions owned by Tenant or installed by Tenant at its expense in the Premises shall be and remain the property of Tenant and may be removed by Tenant at any time during the term
of this Lease provided Tenant is not in default hereunder, and provided further that Tenant shall repair any damage caused by such removal. All business and trade fixtures, machinery and equipment, furniture and movable partitions not so removed by
Tenant prior to the termination of the Lease shall become the property of Landlord without liability on Landlord’s part to pay for the same. 
  

	8.	Maintenance and Repair 

 Except as hereinafter provided, Tenant shall maintain and keep
the interior of the Premises in good repair, free of refuse and rubbish and shall return the same at the expiration or termination of this Lease in as good condition as received by Tenant, ordinary wear and tear, damage or destruction by fire,
flood, storm, civil commotion or other unavoidable causes excepted; provided, however, that if alterations, additions and/or installations shall have been made by Tenant as provided for in this Lease, Tenant shall not be required to restore the
Premises to the condition in which they were prior to such alterations, additions and/or installations except as hereinafter provided. 

Landlord shall be responsible for maintaining and providing all maintenance and custodial services for the interior space within their leased
spaces within the building, consistent with Landlord’s policies and procedures. 
 Landlord shall, without expense to Tenant, maintain
and make all necessary repairs to the foundations, structure, load bearing walls, roof, gutters, downspouts, elevators, water mains, gas and sewer lines, sidewalks, private roadways, landscape, parking areas (except as provided in Section 27
herein), common areas, and loading docks, if any, on or appurtenant to the Premises. 
  

	9.	Common Areas 

 In addition to the parking areas, as designated in Section 27, the
interior lobby and hallways are accessible to the Tenant. 
  

	10.	Indemnity 

 Tenant agrees to indemnify and hold Landlord, its Regents,
employees, and agents harmless against all claims, demands, costs and expenses, including reasonable attorney’s fees for the defense thereof, arising from Tenant’s conduct, occupancy or management of Tenant’s business, its use of the
Premises, from construction of improvements by Tenant, from any breach on the part of the Tenant of any conditions of this Lease, or from any negligence of Tenant, its agents, servants, contractors or employees in or about the Premises.
Notwithstanding anything to the contrary contained herein, the foregoing provision shall not be construed to make Tenant responsible for loss, damage, liability or expense resulting from injuries caused by any negligence or intentional misconduct of
Landlord, its agents, servants, contractors or employees. In case of any action or proceeding brought against Landlord by reason of such claim as is described in the initial sentence of this Paragraph 10, Tenant, upon notice from Landlord, covenants
to defend such action or proceeding by counsel reasonably acceptable to Landlord subject to the statutory duties of the Texas Attorney General. 

  
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	11.	Insurance 

 Landlord covenants and agrees that throughout the term of this Lease it will
insure or self-insure the Building and the Building improvements (excluding any property with respect to which tenants are obligated to insure) through its self-insurance program with the State of Texas subject to the limits of the Texas Tort Claims
Act. 
 Tenant covenants and agrees that throughout the term of this Lease it will insure its Premises and improvements against damage by
fire including extended coverage, vandalism and malicious mischief and comprehensive general liability insurance with limits of at least $1,000,000/$2,000,000 for bodily injury and property damage. Tenant shall provide Landlord with certificates
evidencing the aforesaid insurance coverage upon request and all the said policies shall name Tenant as insured party and Landlord as an additional insured party. Said policies shall also provide that the insurer shall endeavor to provide thirty
(30) days’ written notice to Landlord prior to suspension, termination cancellation, or modification. 
  

	12.	Compliance with Laws 

 Tenant acknowledges that no trade or occupation shall be conducted
in the Premises or use made thereof which is not in accordance with the purpose indicated in Section 4 or which will be unlawful, improper, excessively noisy or offensive, or contrary to any law or any municipal by-law or ordinance in force in
the state, city or town in which the Premises are situated. Tenant shall comply with all applicable Landlord policies and procedures. 
 A.
Tenant shall give prompt notice to Landlord of any written notice it receives of the violation of any law or requirement of public authority, and at its own expense shall comply with all laws and requirements of public authorities which shall, with
respect to the Premises or Tenant’s use and occupation thereof, or the abatement of any nuisance, impose any obligation, order or duty on Landlord or Tenant arising from (i) Tenant’s use of the Premises, (ii) the manner of
conduct of Tenant’s business or operation of its installations, equipment or other property, (iii) any cause or condition created by or at the instance of Tenant, other than by Landlord’s performance of any work for or on behalf of
Tenant, or (iv) breach of obligations of Tenant under this Lease. Tenant, however, shall not be so required to make any structural or other substantial change in the Premises. Furthermore, Tenant need not comply with any such law or requirement
of public authority so long as Tenant shall be contesting the validity thereof or the applicability thereof to the Premises, in accordance with subdivision C of this paragraph. 

B. Landlord, at its expense, shall comply with such other laws and requirements of public authority as shall affect the Premises (except those
arising out of Tenant’s preparation of the Premises for its use), but may similarly contest the same subject to conditions reciprocal to section (i) and (ii) of subdivision C of this section. 

C. Tenant may, at its expense (and if necessary in the name of, but without expense to, Landlord) contest, by appropriate proceedings
prosecuted diligently and in good faith, the validity, or applicability to the Premises, of any law or requirement of public authority and Landlord shall cooperate with Tenant in such proceedings, provided that: 

 

	 	  	Landlord shall not be subject to any fine or criminal penalty or to prosecution for a crime nor shall the Premises or any part thereof be subject to being condemned or vacated, by reason of noncompliance or otherwise by
reason of such contest. 


  
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	 	ii.	Indemnification. Tenant shall defend, indemnify, and hold harmless the Landlord its Regents, employees and agents against all liability, loss or damage that Landlord shall suffer by reason of such
noncompliance or contest, including reasonable attorney’s fees and other expenses reasonably incurred by Landlord. Tenant shall keep Landlord advised as to the status of such proceedings. 


 

	13.	Signs 

 Tenant, in accordance with Section 12, shall have the right to erect, affix
or display on the interior walls, interior doors, or interior windows of the Building or the Premises, such signs or sign advertising its business as Tenant may consider necessary or desirable, subject to the consent of and written approval of the
Landlord, whose consent shall not be unreasonably withheld, conditioned or delayed. 
  

	14.	Casualty Loss 

 In the event that the Premises are damaged by fire or other casualty,
Landlord shall forthwith proceed to repair and restore the Premises to the end that space of the same size and utility are available as expeditiously as possible. Tenant’s rent shall be abated in just proportion during the period of impaired
use of the Premises. If more than fifty percent (50%) of the inside space of the Building or the Premises is so damaged, either Landlord or Tenant may cancel this Lease on thirty (30) days written notice to the other party and rent shall
be apportioned as of the date of the casualty. If a registered engineer or architect jointly acceptable to Landlord and Tenant shall notify them in writing within thirty (30) days after such fire or casualty that, in his opinion, the damage to
the Premises cannot be repaired so as to substantially restore the Premises to their former condition within ninety (90) days after such fire or casualty, or if the Premises are in fact not restored to substantially the same condition as prior
to such fire or casualty within ninety (90) days after such occurrence, then this Lease may be terminated by either Landlord or Tenant upon written notice to the other party, and rent shall be apportioned as of the termination date. The rights
of cancellation and termination afforded to the parties by this Paragraph 14 shall not be affected or extended by reason of the happening of any event described in Paragraph 21. 

 

	15.	Condemnation 

 In the event the Premises shall be taken for public use by the city,
state, federal government, public authority or other corporation having the power of eminent domain, then this Lease shall terminate as of the date on which possession thereof shall be taken for such public use or, at the option of Tenant, as of the
date on which the Premises shall become unsuitable for Tenant’s regular business by reason of such taking; provided, however, that if only a part (less than 20%) of the Premises shall be so taken, such termination shall be at the option of
Tenant only. If such a taking of only a part of the Premises occurs, and Tenant elects not to terminate this Lease, there shall be a proportionate reduction of the rent to be paid under this Lease from and after the date such possession is taken for
public use. Tenant shall not have the right to participate, directly or indirectly, in any award for such public taking on account of such public taking. 
  

	16.	Default 

 In the event that either of the parties hereto shall fail to perform any
covenant required to be performed by such party under the terms and provisions of this Lease, including Tenant’s covenant to pay rent, and such failure shall continue un-remedied or uncorrected for a period of fifteen (15) days


  
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or such additional time as is reasonably required to correct any such default after the service of written notice upon such party by the other party hereto, specifying such failure, this Lease
may be terminated, at the option of the party serving such notice, at the expiration of such fifteen (15) day period; provided, however, that such termination shall not relieve the party so failing from liability to the other party for such
damages as may be suffered by reason of such failure. 
  

	17.	Landlord’s Right to Enter Premises 

 Tenant shall permit Landlord or its agent to
enter at all reasonable times and upon reasonable notice (and in case of emergency at any time) to make such alterations or repairs therein as may be necessary for the safety or the preservation thereof, or for any other reasonable purposes. Tenant
shall also permit Landlord or its agents, on or after sixty (60) days preceding the expiration of the term of this Lease, to show the Premises to prospective tenants at reasonable times, and to place notices on the front of said Premises, or on
any part thereof, offering the Premises for lease or for sale. 
  

	18.	Assignment, Subletting 

 Tenant shall not assign this Lease or sublet the whole or any
part of the Premises without the prior written consent of Landlord. In the event of any such assignment, Tenant shall deliver to Landlord within a reasonable time thereafter, a written agreement (with a copy of the Lease attached and incorporated
therein) from the assignee agreeing with Landlord to perform all of the terms, covenants, and conditions of Tenant contained in this Lease. 
  

	19.	Holding Over 

 If Tenant or anyone claiming under Tenant shall remain in possession of
the Premises or any part thereof after the expiration of the term of this Lease without any agreement in writing between the Landlord and Tenant with respect thereto, the person remaining in possession shall be deemed a month-to-month tenant subject
to all terms and conditions of this lease, except that the rental rate shall be equal to one hundred and twenty-five percent (125%) of the rent in effect upon the date of such expiration or termination until the tenancy is terminated in a
manner provided by law. 
  

	20.	Estoppel Certificates 

 Upon not less than thirty (30) days prior written request,
either Landlord or Tenant agrees, in favor of the other, to execute, acknowledge and deliver a statement in writing certifying that this Lease is unmodified and in full force and effect (or, if there have been any modifications that the same are in
full force and effect as modified and stating the modifications), the dates to which rent and other charges required under this Lease have been paid, and any other information reasonably requested. Any such statement delivered pursuant to this
paragraph may be relied upon by any prospective purchaser, mortgagee or lending source. 
  

	21.	Acts Of Nature 

 In any case where either party hereto is required to do any act, delays
caused by or resulting from Acts of Nature, war, civil commotion, fire, flood or other casualty, labor difficulties, shortages of labor, materials or equipment, unusual government regulations, unusually severe weather, or other causes beyond such
party’s reasonable control shall not be counted in determining the time during which such act shall be completed, whether such time be designated by a fixed date, a fixed time or “a reasonable time”, and such time shall be deemed to
be extended by the period of such delay. The provisions of this Paragraph 21 shall not be applied, however, to affect other party’s right to terminate this Lease under Paragraphs 2, 14 and 22. 

  
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	22.	Quiet Enjoyment 

 Landlord agrees that if Tenant pays the rent and performs and observes
the agreements, conditions and other provisions on its part to be performed and observed, Tenant shall and may peaceably and quietly have, hold and enjoy the Premises during the term of this Lease and any extensions thereof without any manner of
hindrance or molestation from Landlord or anyone claiming under Landlord, subject, however, to the terms of this Lease and any instruments having a prior lien. Tenant shall have the right to terminate this Lease by notice to Landlord for breach of
any covenant contained in this Paragraph. 
  

	23.	Notice 

 Whenever in this Lease it is provided that notice shall or may be given to or
served upon either of the parties by the other, and whenever either of the parties shall desire to give or serve upon the other any notice with respect to this Lease or the Premises, each such notice shall be in writing and any law or statute to the
contrary notwithstanding, shall not be effective for any purpose unless the same shall be given or serviced as follows: 
  

	 	i.	If given or served by Landlord, by mailing the same to Tenant by registered or certified mail, return receipt requested, addressed to Tenant at: 


Mark Nuttall 
 VP, Quality
Assurance & Regulatory Compliance 
 ZS Pharma, Inc. 

508 Wrangler Drive, Suite 100 

Coppell, Texas 75019 
  

	 	ii.	If given or served by Tenant, by mailing the same to Landlord by registered or certified mail, return receipt requested, addressed to Landlord at: University of North Texas Health Science Center at Fort Worth, 3500 Camp
Bowie Blvd., Fort Worth Texas, 76107, Attn: Robert McClain, Ph.D., Associate Vice President for Technology Transfer & Commercialization or such other address as Landlord may from time to time designate by notice given to Tenant.


  

	24.	Self-Help 

 If Tenant shall default in the performance or observance of any agreement or
condition in this Lease contained on its part to be performed or observed, other than an obligation to pay money, and shall not cure such default as provided herein, Landlord may after written notice to Tenant, at its option, without waiving any
claim for damages for breach of this Lease, at any time thereafter, cure such default for the account of Tenant and any amount paid or any liability incurred by Landlord in so doing shall be deemed paid or incurred for the account of Tenant, and
Tenant agrees to promptly reimburse Landlord thereafter and save Landlord its Regents, employees, and agents harmless therefrom. 

  
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	25.	Contingencies 

 In the event that applicable zoning laws or regulations prohibit Tenant
from conducting its business as described herein, this Lease shall terminate and neither party shall have any further obligation to the other party hereunder. 
  

	26.	Environmental Regulations. Tenant will not permit any Hazardous Substance to be used, stored, generated or disposed of on, in or about, or transported to or from, the Premises, by Tenant, Tenant’s agents,
employees, contractors, invitees, subtenants, or concessionaires without first obtaining Landlord’s written consent, which shall not unreasonably be withheld. If Landlord consents, all Hazardous Substances must be handled at Tenant’s sole
cost and expense, in compliance with all applicable state, federal or local governmental requirements, using all necessary and appropriate precautions. Upon arrival of any approved quantity of Hazardous Materials on Premises, Tenant will immediately
provide to Landlord material safety data sheets. If Tenant breaches these obligations, or if the presence of Hazardous Substances on, in or about the Space caused or permitted by Tenant results in contamination of any part of the Premises or
Landlord’s surrounding property, or if contamination by Hazardous Substances otherwise occurs in a manner for which Tenant is legally liable, then Tenant will indemnify and hold harmless Landlord, from and against any and all claims,
actions, damages, fines, judgments, penalties, costs, liabilities, losses and expenses (including, without limitation, any sums paid for settlement of claims, court costs, attorneys’ fees, consultant and expert fees) arising during or after the
expiration or termination of this Agreement as a result of any breach or contamination. Without limitation, if Tenant causes or permits the presence of any Hazardous Substance on, in or about the Premises and this results in contamination of any
part of the Premises, Tenant will promptly, at its sole cost and expense, take all necessary actions to return the Premises and any adjacent property to the condition existing prior to the presence of any Hazardous Substance; provided, however,
Tenant shall first obtain Landlord’s approval for any such remedial action. “Hazardous Substance” means any substance regulated by any local government, the State of Texas or the United States government. “Hazardous
Substance” includes any material or substances which are defined as “hazardous material,” “hazardous waste,” “extremely hazardous waste” or a “hazardous substance” pursuant to state, federal or local
government law. “Hazardous Substance” includes but is not restricted to asbestos, polychlorobiphenyls and petroleum. In the event Tenant brings such substances on the Premises, without Landlord’s written consent then Landlord may
terminate this Agreement pursuant to Section 16 herein. 

  

	27.	Miscellaneous 

 The parties agree to reasonably cooperate with each other in the
development of marketing initiatives to promote the relationship between the parties, including but not limited to: news media press releases, brochures and pamphlets, and open house events. Unless first approved in writing, any other use of
Landlord’s name shall be limited to statements of fact and shall not imply endorsement by Landlord of Tenant’s products or services. 

This Lease shall be governed by and construed in accordance with the laws of the State of Texas, and if any provisions of this Lease shall to
any extent be invalid, the remainder of this Lease shall not be affected thereby. Venue for any legal proceeding shall lie in a court of competent jurisdiction in Tarrant County. 

There are no oral or written agreements between Landlord and Tenant affecting this Lease, and this Lease contains the entire agreement of the
parties concerning the subject matter described herein. 

  
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 This Lease supersedes any prior written or oral agreements between the parties concerning the
subject matter described herein. This Lease may be amended only by instruments in writing executed by the duly authorized representatives of Landlord and Tenant. 

The titles of the several paragraphs contained herein are for convenience only and shall not be considered in construing this Lease. 

Unless repugnant to the context, the words “Landlord” and “Tenant” appearing in this Lease shall be construed to mean those
named above and their respective heirs, executors, administrators, successors and assigns and those claiming through or under them respectively. 

Tenant shall have use of available parking garage adjacent to the Premises. Notwithstanding the foregoing, Landlord may reassign parking spaces
during the term of this Lease at its sole discretion and Tenant is not entitled to any reserved parking. Tenant understands and agrees that others including UNTHSC staff and visitors will also have available use of said parking. 

Tenant represents and certifies that it is not currently delinquent in the payment of any franchise taxes owed to the State of Texas and is in
good standing with the State of Texas. Tenant further certifies that Tenant is not a child support obligator who is more than 30 days delinquent in paying child support. Lessee acknowledges that the Lease may be immediately terminated if this
certification is inaccurate. 
 Tenant is fully informed concerning and is in full compliance with its obligations, if any, under the
following: (1) Equal Employment Opportunities provisions of the Civil Rights Act of 1964, as amended; (2) Executive Order 11701, as amended; (3) Executive Order 11246, as amended; (4) Rehabilitation Act of 1973, as implemented by
41 CFR 60-741, as amended; (5) Vietnam Era Veterans Readjustment Act of 1974 as implemented by 41 CFR 60-250, as amended; and (6) Fair Labor Standards Act of 1938, Sections 6, 7, and 12, as amended 

IN WITNESS WHEREOF, the parties hereto have executed this Lease the day and year first above written. 

 

			
	TENANT:	 	ZS PHARMA, INC.
		
	By:	 	/s/ Al Guillem
	Name:	 	Al Guillem, Ph.D.
	Title:	 	President & CEO
	Date:	 	8/9/2013


  

			
	LANDLORD:	 	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER
		
	By:	 	/s/ John Harman
	Name:	 	 John Harman, MBA, CPA, CGMA, CMPE

	Title:	 	 Senior Vice President for Finance and CFO

	Date:	 	8/22/2013
	
	HSC Contract # N-14855a



  
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