EX-4.2



 Exhibit 4.2 

PFIZER INC. 
 and 

THE BANK OF NEW YORK MELLON, 

Trustee 
 FOURTH SUPPLEMENTAL
INDENTURE 
 Dated as of May 15, 2014 

to 
 INDENTURE 

Dated as of January 30, 2001 

Floating Rate Notes due 2017 

1.100% Notes due 2017 
 2.100% Notes
due 2019 
 3.400% Notes due 2024 

4.400% Notes due 2044 







 TABLE OF CONTENTS 
  

							
	 	 	 	  	Page	 
	
	ARTICLE ONE	  
	
	DEFINITIONS	  
			
	Section 101.	 	 Definition of Terms
	  	 	2	  
	
	ARTICLE TWO	  
	
	GENERAL TERMS AND CONDITIONS OF THE FLOATING RATE NOTES	  
			
	Section 201.	 	 Designation and Principal and Amount
	  	 	2	  
	Section 202.	 	 Maturity
	  	 	2	  
	Section 203.	 	 Further Issues
	  	 	2	  
	Section 204.	 	 Global Notes
	  	 	2	  
	Section 205.	 	 Interest
	  	 	3	  
	Section 206.	 	 Authorized Denominations
	  	 	5	  
	Section 207.	 	 No Optional Redemption
	  	 	5	  
	Section 208.	 	 Appointment of Agents
	  	 	5	  
	
	ARTICLE THREE	  
	
	GENERAL TERMS AND CONDITIONS OF THE 2017 NOTES	  
			
	Section 301.	 	 Designation and Principal Amount
	  	 	5	  
	Section 302.	 	 Maturity
	  	 	5	  
	Section 303.	 	 Further Issues
	  	 	5	  
	Section 304.	 	 Global Notes
	  	 	5	  
	Section 305.	 	 Interest
	  	 	6	  
	Section 306.	 	 Authorized Denominations
	  	 	6	  
	Section 307.	 	 Redemption
	  	 	6	  
	Section 308.	 	 Appointment of Agents
	  	 	6	  
	
	ARTICLE FOUR	  
	
	GENERAL TERMS AND CONDITIONS OF THE 2019 NOTES	  
			
	Section 401.	 	 Designation and Principal Amount
	  	 	6	  
	Section 402.	 	 Maturity
	  	 	6	  
	Section 403.	 	 Further Issues
	  	 	6	  
	Section 404.	 	 Global Notes
	  	 	7	  
	Section 405.	 	 Interest
	  	 	7	  
	Section 406.	 	 Authorized Denominations
	  	 	7	  
	Section 407.	 	 Redemption
	  	 	7	  
	Section 408.	 	 Appointment of Agents
	  	 	7	  


  
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	ARTICLE FIVE	  
	
	GENERAL TERMS AND CONDITIONS OF THE 2024 NOTES	  
			
	Section 501.	 	 Designation and Principal Amount
	  	 	7	  
	Section 502.	 	 Maturity
	  	 	7	  
	Section 503.	 	 Further Issues
	  	 	7	  
	Section 504.	 	 Global Notes
	  	 	8	  
	Section 505.	 	 Interest
	  	 	8	  
	Section 506.	 	 Authorized Denominations
	  	 	8	  
	Section 507.	 	 Redemption
	  	 	8	  
	Section 508.	 	 Appointment of Agents
	  	 	8	  
	
	ARTICLE SIX	  
	
	GENERAL TERMS AND CONDITIONS OF THE 2044 NOTES	  
			
	Section 601.	 	 Designation and Principal Amount
	  	 	8	  
	Section 602.	 	 Maturity
	  	 	9	  
	Section 603.	 	 Further Issues
	  	 	9	  
	Section 604.	 	 Global Notes
	  	 	9	  
	Section 605.	 	 Interest
	  	 	9	  
	Section 606.	 	 Authorized Denominations
	  	 	9	  
	Section 607.	 	 Redemption
	  	 	9	  
	Section 608.	 	 Appointment of Agent
	  	 	9	  
	
	ARTICLE SEVEN	  
	
	OPTIONAL REDEMPTION OF CERTAIN NOTES; NO SINKING FUND	  
			
	Section 701.	 	 Optional Redemption by Company
	  	 	10	  
	Section 702.	 	 No Sinking Fund
	  	 	13	  
	
	ARTICLE EIGHT	  
	
	FORMS OF NOTES	  
			
	Section 801.	 	 Form of Floating Rate Note
	  	 	13	  
	Section 802.	 	 Form of 2017 Note
	  	 	13	  
	Section 803.	 	 Form of 2019 Note
	  	 	13	  
	Section 804.	 	 Form of 2024 Note
	  	 	13	  
	Section 805.	 	 Form of 2044 Note
	  	 	13	  


  
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	ARTICLE NINE	  
	
	ORIGINAL ISSUE AMOUNT OF NOTES	  
			
	Section 901.	 	 Original Issue Amount of the Floating Rate Notes
	  	 	13	  
	Section 902.	 	 Original Issue Amount of the 2017 Notes
	  	 	14	  
	Section 903.	 	 Original Issue Amount of the 2019 Notes
	  	 	14	  
	Section 904.	 	 Original Issue Amount of the 2024 Notes
	  	 	14	  
	Section 905.	 	 Original Issue Amount of the 2044 Notes
	  	 	14	  
	
	ARTICLE TEN	  
	
	MISCELLANEOUS	  
			
	Section 1001.	 	 Ratification of Indenture
	  	 	14	  
	Section 1002.	 	 Trustee Not Responsible for Recitals
	  	 	14	  
	Section 1003.	 	 Governing Law
	  	 	14	  
	Section 1004.	 	 Separability
	  	 	14	  
	Section 1005.	 	 Counterparts
	  	 	15	  
	Section 1006.	 	 Trust Indenture Act
	  	 	15	  

 Exhibits 
  

			
	Exhibit A	 	Form of Floating Rate Note
	Exhibit B	 	Form of 2017 Note
	Exhibit C	 	Form of 2019 Note
	Exhibit D	 	Form of 2024 Note
	Exhibit E	 	Form of 2044 Note


  
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 FOURTH SUPPLEMENTAL INDENTURE, dated as of May 15, 2014 (the “Fourth Supplemental
Indenture”), between Pfizer Inc., a corporation duly organized and existing under the laws of the State of Delaware, having its principal office at 235 East 42nd Street, New York, New York 10017 (the “Company”), and The Bank of New
York Mellon (formerly The Bank of New York, a New York banking corporation (successor to JPMorgan Chase Bank, N.A. (formerly JPMorgan Chase Bank, formerly The Chase Manhattan Bank (successor to The Chase Manhattan Bank (National Association)))), as
trustee (the “Trustee”). 
 WHEREAS, the Company executed and delivered the indenture, dated as of January 30, 2001, to the
Trustee (the “Indenture”), to provide for the issuance of the Company’s notes, bonds, debentures or any other evidences of indebtedness (the “Securities”), in one or more fully registered series; 

WHEREAS, pursuant to Section 901 of the Indenture, the Company desires to provide for the issuance of (i) a new series of its
Securities to be known as its Floating Rate Notes due 2017 (the “Floating Rate Notes”), (ii) a new series of its Securities to be known as its 1.100% Notes due 2017 (the “2017 Notes”), (iii) a new series of its
Securities to be known as its 2.100% Notes due 2019 (the “2019 Notes”), (iv) a new series of its Securities to be known as its 3.400% Notes due 2024 (the “2024 Notes”) and (v) a new series of its Securities to be known
as its 4.400% Notes due 2044 (the “2044 Notes” and, together with the Floating Rate Notes, 2017 Notes, the 2019 Notes and the 2024 Notes, the “Notes”), and to establish the forms of the Notes thereof, as provided in
Section 202 of the Indenture, and to set forth the terms thereof, as provided in Section 301 of the Indenture; 
 WHEREAS, the
Board of Directors of the Company, pursuant to resolutions duly adopted, has duly authorized the issuance of the Company’s debt securities and the Securities Issuance Committee of the Company, pursuant to a resolution duly adopted on
May 12, 2014, has duly authorized the issuance of $500,000,000 aggregate principal amount of the Floating Rate Notes, $1,000,000,000 aggregate principal amount of the 2017 Notes, $1,500,000,000 aggregate principal amount of the 2019 Notes,
$1,000,000,000 aggregate principal amount of the 2024 Notes and $500,000,000 aggregate principal amount of the 2044 Notes, and has authorized the proper officers of the Company to execute any and all appropriate documents necessary or appropriate to
effect such issuance; 
 WHEREAS, the Company has requested that the Trustee execute and deliver this Fourth Supplemental Indenture; and

 WHEREAS, all things necessary to make this Fourth Supplemental Indenture a valid agreement of the Company, in accordance with its terms,
and to make the Notes, when executed by the Company and authenticated and delivered by the Trustee, the valid obligations of the Company, have been done; 

NOW THEREFORE, in consideration of the premises and the purchase and acceptance of the Notes by the Holders thereof, and for the purpose of
setting forth, 







 
as provided in the Indenture, the forms and terms of the Notes, it is mutually covenanted and agreed, for the equal and proportionate benefit of all Holders of the Notes, as follows: 

ARTICLE ONE 

DEFINITIONS 

Section 101. Definition of Terms. Unless the context otherwise requires: 

(a) each term defined in the Indenture has the same meaning when used in this Fourth Supplemental Indenture; 

(b) each term defined anywhere in this Fourth Supplemental Indenture has the same meaning throughout; 

(c) the singular includes the plural and vice versa; and 

(d) headings are for convenience of reference only and do not affect interpretation. 

ARTICLE TWO 
 GENERAL
TERMS AND CONDITIONS OF THE FLOATING RATE NOTES 
 Section 201. Designation and Principal and Amount. There is hereby
authorized and established a series of Securities under the Indenture, designated as the “Floating Rate Notes due 2017”, which is not limited in aggregate principal amount. The aggregate principal amount of the Floating Rate Notes to be
issued on the date hereof is set forth in Article Nine herein. 
 Section 202. Maturity. The Stated Maturity of principal of the
Floating Rate Notes is May 15, 2017. 
 Section 203. Further Issues. The Company may from time to time, without the consent
of the Holders of the Floating Rate Notes, issue additional Floating Rate Notes. Any such additional Floating Rate Notes will have the same ranking, interest rate, maturity date and other terms as the Floating Rate Notes herein provided for. Any
such additional Floating Rate Notes, together with the Floating Rate Notes herein provided for, will constitute a single series of Securities under the Indenture. No additional Floating Rate Notes may be issued if an Event of Default has occurred
and is continuing with respect to the Floating Rate Notes. The Company will not issue any additional Floating Rate Notes intended to form a single series with the Floating Rate Notes herein provided for unless such additional Floating Rate Notes
will be fungible with the Floating Rate Notes herein provided for, for U.S. federal income tax purposes. 
 Section 204. Global
Notes. Upon their original issuance, the Floating Rate Notes will be represented by one or more Global Securities registered in the name of 

  
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Cede & Co., the nominee of The Depository Trust Company (“DTC”). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in
the name of Cede & Co. 
 Section 205. Interest. (a) Interest on the Floating Rate Notes will accrue at a per
annum rate equal to LIBOR, as determined by the Calculation Agent, plus 0.150%. The Calculation Agent will set the initial interest rate on May 15, 2014 and reset the interest rate on each Interest Payment Date (each such date, an
“Interest Reset Date”). The second London business day preceding an Interest Reset Date will be the “Interest Determination Date” for that Interest Reset Date. The interest rate in effect on each date that is not an Interest
Reset Date will be the interest rate determined as of the Interest Determination Date pertaining to the immediately preceding Interest Reset Date. The interest rate in effect on any day that is an Interest Reset Date will be the interest rate
determined as of the Interest Determination Date pertaining to the Interest Reset Date. Interest shall be computed on the basis of the actual number of days in the relevant interest period and a 360-day year. 

(b) Interest on the Floating Rate Notes will accrue from and including May 15, 2014, to, but excluding, the first Interest Payment Date
and thereafter from and including the immediately preceding Interest Payment Date to which interest has been paid or duly provided for to, but excluding, the next Interest Payment Date. Interest on the Floating Rate Notes shall be payable quarterly
in arrears and the Interest Payment Dates on which such interest shall be payable are February 15, May 15, August 15 and November 15, beginning on August 15, 2014; and the Regular Record Date for the interest
payable on any Interest Payment Date is the close of business on the February 1, May 1, August 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding the relevant Interest Payment
Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day. 

(c) The following defined terms used in this Article Two shall, unless the context otherwise requires, have the meanings specified below. 

“Calculation Agent” means The Bank of New York Mellon, a New York banking corporation, and its successors and assigns. The
Calculation Agent shall serve as the calculation agent hereunder unless and until a successor calculation agent is appointed by the Company. 

“LIBOR” will be determined by the Calculation Agent in accordance with the following provisions: 

(i) With respect to any Interest Determination Date, LIBOR will be the rate for deposits in United States dollars having a
maturity of three months commencing on the first day of the applicable interest period that appears on Reuters Page LIBOR01 as of 11:00 a.m., London time, on that Interest Determination Date. If, on an Interest Determination Date, such rate does not
appear on Reuters Page LIBOR01 as of 11:00 a.m., London time, or if Reuters 

  
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Page LIBOR01 is not available on such date, the Calculation Agent will obtain such rate from Bloomberg L.P.’s page “BBAM.” If no rate appears on Reuters Page LIBOR01 or Bloomberg
L.P. page BBAM as of approximately 11:00 a.m., London time, on such Interest Determination Date, LIBOR for that Interest Determination Date will be determined in accordance with the provisions described in (ii) below. 

(ii) With respect to an Interest Determination Date on which no rate appears on Reuters Page LIBOR01 or Bloomberg L.P. page
BBAM, as specified in (i) above, the Calculation Agent will request the principal London offices of each of four major reference banks in the London interbank market, as selected by the Calculation Agent (after consultation with the Company),
to provide the Calculation Agent with its offered quotation for deposits in United States dollars for the period of three months, commencing on the first day of the applicable interest period, to prime banks in the London interbank market at
approximately 11:00 a.m., London time, on that Interest Determination Date and in a principal amount that is representative for a single transaction in United States dollars in that market at that time. If at least two quotations are provided, then
LIBOR on that Interest Determination Date will be the arithmetic mean of those quotations. If fewer than two quotations are provided, then LIBOR on the Interest Determination Date will be the arithmetic mean of the rates quoted at approximately
11:00 a.m., in The City of New York, on the Interest Determination Date by three major banks in The City of New York selected by the Calculation Agent (after consultation with the Company) for loans in United States dollars to leading European
banks, having a three-month maturity and in a principal amount that is representative for a single transaction in United States dollars in that market at that time. If, however, the banks selected by the Calculation Agent are not providing
quotations in the manner described by the previous sentence, LIBOR determined as of that Interest Determination Date will be LIBOR in effect on that Interest Determination Date. 

“Reuters Page LIBOR01” means the display designated on page LIBOR01 by Reuters Group plc (or such other page as may replace the
LIBOR01 page on that service (or any successor service) or such other service as may be nominated by the British Bankers’ Association for the purpose of displaying London interbank offered rates for U.S. dollar deposits). 

(d) All percentages resulting from any calculation of the interest rate on the Floating Rate Notes will be rounded to the nearest one
hundred-thousandth of a percentage point with five one millionths of a percentage point rounded upwards (e.g., 9.876545% (or .09876545) would be rounded to 9.87655% (or .0987655)), and all dollar amounts used in or resulting from such calculation on
the Floating Rate Notes will be rounded to the nearest cent (with one-half cent being rounded upward). Each calculation of the interest rate on the Floating Rate Notes by the Calculation Agent will (in the absence of manifest error) be final and
binding on the Holders of the Floating Rate Notes and the Company. 

  
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 Section 206. Authorized Denominations. The Floating Rate Notes shall be issuable in
denominations of $2,000 and integral multiples of $1,000 in excess thereof. 
 Section 207. No Optional Redemption. The Company
may not redeem the Floating Rate Notes at its option prior to Stated Maturity. 
 Section 208. Appointment of Agents.
(a) The Trustee will initially be the Security Registrar and Paying Agent for the Floating Rate Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

(b) So long as any of the Floating Rate Notes remain outstanding, there shall at all times be a calculation agent, which shall initially be
the Calculation Agent. If the Calculation Agent is unable or unwilling to continue to act as the calculation agent or if it fails to calculate properly the interest rate on the Floating Rate Notes for any interest period, the Company will appoint
another leading commercial or investment bank engaged in the London interbank market to act as calculation agent in its place. Any such calculation agent may not resign its duties without a successor having been appointed. 

ARTICLE THREE 
 GENERAL
TERMS AND CONDITIONS OF THE 2017 NOTES 
 Section 301. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “1.100% Notes due 2017”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2017 Notes to be issued on the date hereof is set
forth in Article Nine herein. 
 Section 302. Maturity. The Stated Maturity of principal of the 2017 Notes is May 15, 2017.

 Section 303. Further Issues. The Company may from time to time, without the consent of the Holders of the 2017 Notes, issue
additional 2017 Notes. Any such additional 2017 Notes will have the same ranking, interest rate, maturity date and other terms as the 2017 Notes herein provided for. Any such additional 2017 Notes, together with the 2017 Notes herein provided for,
will constitute a single series of Securities under the Indenture. No additional 2017 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2017 Notes. The Company will not issue any additional 2017 Notes
intended to form a single series with the 2017 Notes herein provided for unless such additional 2017 Notes will be fungible with the 2017 Notes herein provided for, for U.S. federal income tax purposes. 

Section 304. Global Notes. Upon their original issuance, the 2017 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede & Co. 

  
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 Section 305. Interest. The 2017 Notes will bear interest (computed on the basis of a
360-day year consisting of twelve 30-day months) from May 15, 2014 at the rate of 1.100% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued
from May 15, 2014, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and November 15, beginning on
November 15, 2014; and the Regular Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding the
relevant Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will
accrue on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. 

Section 306. Authorized Denominations. The 2017 Notes shall be issuable in denominations of $2,000 and integral multiples of
$1,000 in excess thereof. 
 Section 307. Redemption. The 2017 Notes are subject to redemption at the option of the Company as
described in Article Seven hereof. 
 Section 308. Appointment of Agents. The Trustee will initially be the Security Registrar
and Paying Agent for the 2017 Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

ARTICLE FOUR 
 GENERAL
TERMS AND CONDITIONS OF THE 2019 NOTES 
 Section 401. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “2.100% Notes due 2019”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2019 Notes to be issued on the date hereof is set
forth in Article Nine herein. 
 Section 402. Maturity. The Stated Maturity of principal of the 2019 Notes is May 15, 2019.

 Section 403. Further Issues. The Company may from time to time, without the consent of the Holders of the 2019 Notes, issue
additional 2019 Notes. Any such additional 2019 Notes will have the same ranking, interest rate, maturity date and other terms as the 2019 Notes herein provided for. Any such additional 2019 Notes, together with the 2019 Notes herein provided for,
will constitute a single series of Securities under the Indenture. No additional 2019 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2019 Notes. The Company will not issue any additional 2019 Notes
intended to form a single series with the 2019 Notes herein provided for unless such additional 2019 Notes will be fungible with the 2019 Notes herein provided for, for U.S. federal income tax purposes. 

  
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 Section 404. Global Notes. Upon their original issuance, the 2019 Notes will be
represented by one or more Global Securities registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede & Co. 
 Section 405. Interest. The 2019 Notes will bear interest (computed on the basis of a 360-day year
consisting of twelve 30-day months) from May 15, 2014 at the rate of 2.100% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from
May 15, 2014, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and November 15, beginning on
November 15, 2014; and the Regular Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding the
relevant Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will
accrue on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. 

Section 406. Authorized Denominations. The 2019 Notes shall be issuable in denominations of $2,000 and integral multiples of
$1,000 in excess thereof. 
 Section 407. Redemption. The 2019 Notes are subject to redemption at the option of the Company as
described in Article Seven hereof. 
 Section 408. Appointment of Agents. The Trustee will initially be the Security Registrar
and Paying Agent for the 2019 Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

ARTICLE FIVE 
 GENERAL
TERMS AND CONDITIONS OF THE 2024 NOTES 
 Section 501. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “3.400% Notes due 2024”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2024 Notes to be issued on the date hereof is set
forth in Article Nine herein. 
 Section 502. Maturity. The Stated Maturity of principal of the 2024 Notes is May 15, 2024.

 Section 503. Further Issues. The Company may from time to time, without the consent of the Holders of the 2024 Notes, issue
additional 2024 Notes. Any 

  
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such additional 2024 Notes will have the same ranking, interest rate, maturity date and other terms as the 2024 Notes herein provided for. Any such additional 2024 Notes, together with the 2024
Notes herein provided for, will constitute a single series of Securities under the Indenture. No additional 2024 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2024 Notes. The Company will not issue any
additional 2024 Notes intended to form a single series with the 2024 Notes herein provided for unless such additional 2024 Notes will be fungible with the 2024 Notes herein provided for, for U.S. federal income tax purposes. 

Section 504. Global Notes. Upon their original issuance, the 2024 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede & Co. 

Section 505. Interest. The 2024 Notes will bear interest (computed on the basis of a 360-day year consisting of twelve 30-day
months) from May 15, 2014 at the rate of 3.400% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from May 15, 2014, or from the most
recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and November 15, beginning on November 15, 2014; and the Regular Record
Date for the interest payable on any Interest Payment Date is the close of business on the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding the relevant Interest Payment Date. If any Interest
Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that payment for the period from and
after that Interest Payment Date to the date of payment on the next succeeding Business Day. 
 Section 506. Authorized
Denominations. The 2024 Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Section 507. Redemption. The 2024 Notes are subject to redemption at the option of the Company as described in Article Seven
hereof. 
 Section 508. Appointment of Agents. The Trustee will initially be the Security Registrar and Paying Agent for the
2024 Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 
 ARTICLE SIX 

GENERAL TERMS AND CONDITIONS OF THE 2044 NOTES 

Section 601. Designation and Principal Amount. There is hereby authorized and established a series of Securities under the
Indenture, designated as the “4.400% Notes due 2044”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2044 Notes to be issued on the date hereof is set forth in Article Nine herein. 

  
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 Section 602. Maturity. The Stated Maturity of principal of the 2044 Notes is
May 15, 2044. 
 Section 603. Further Issues. The Company may from time to time, without the consent of the Holders of the
2044 Notes, issue additional 2044 Notes. Any such additional 2044 Notes will have the same interest rate, maturity date and other terms as the 2044 Notes herein provided for. Any such additional 2044 Notes, together with the 2044 Notes herein
provided for, will constitute a single series of Securities under the Indenture. No additional 2044 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2044 Notes. The Company will not issue any additional
2044 Notes intended to form a single series with the 2044 Notes herein provided for unless such additional 2044 Notes will be fungible with the 2044 Notes herein provided for, for U.S. federal income tax purposes. 

Section 604. Global Notes. Upon their original issuance, the 2044 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede & Co. 

Section 605. Interest. The 2044 Notes will bear interest (computed on the basis of a 360-day year consisting of twelve 30-day
months) from May 15, 2014 at the rate of 4.400% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from May 15, 2014, or from the most
recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and November 15, beginning on November 15, 2014; and the Regular Record
Date for the interest payable on any Interest Payment Date is the close of business on the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding the relevant Interest Payment Date. If any Interest
Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that payment for the period from and
after that Interest Payment Date to the date of payment on the next succeeding Business Day. 
 Section 606. Authorized
Denominations. The 2044 Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Section 607. Redemption. The 2044 Notes are subject to redemption at the option of the Company as described in Article Seven
hereof. 
 Section 608. Appointment of Agent. The Trustee will initially be the Security Registrar and Paying Agent for the 2044
Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

  
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 ARTICLE SEVEN 

OPTIONAL REDEMPTION OF CERTAIN NOTES; NO SINKING FUND 

Section 701. Optional Redemption by Company. 

(a) The Floating Rate Notes are not subject to optional redemption. 

(b) At the Company’s option, the 2017 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2017
Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2017 Redemption Price”) equal to the greater of the following amounts: 

(i) 100% of the principal amount of the 2017 Notes being redeemed on the relevant 2017 Redemption Date, and 

(ii) the sum of the present values of the remaining scheduled payments of principal and interest on the 2017 Notes being
redeemed on the applicable 2017 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2017 Redemption Date) discounted to such 2017 Redemption Date on a semi-annual basis at the Treasury Rate as
determined by the Independent Investment Banker, plus 4 basis points; 
 plus, in each of the cases of (i) and (ii) above, accrued and
unpaid interest on the 2017 Notes being redeemed to, but excluding, such 2017 Redemption Date. 
 (c) At the Company’s option,
the 2019 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2019 Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2019
Redemption Price”) equal to the greater of the following amounts: 
 (i) 100% of the principal amount of the 2019 Notes
being redeemed on the relevant 2019 Redemption Date, and 
 (ii) the sum of the present values of the remaining scheduled
payments of principal and interest on the 2019 Notes being redeemed on the applicable 2019 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2019 Redemption Date) discounted to such 2019
Redemption Date on a semi-annual basis at the Treasury Rate, as determined by the Independent Investment Banker, plus 7 basis points; 
 plus, in
each of the cases of (i) and (ii) above, accrued and unpaid interest on the 2019 Notes being redeemed to, but excluding, such 2019 Redemption Date. 

  
 -10- 








 (d) At the Company’s option, the 2024 Notes may be redeemed, in whole or in part, at any
time and from time to time (each a “2024 Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2024 Redemption Price”) equal to the greater of the
following amounts: 
 (i) 100% of the principal amount of the 2024 Notes being redeemed on the relevant 2024 Redemption Date,
and 
 (ii) the sum of the present values of the remaining scheduled payments of principal and interest on the 2024 Notes
being redeemed on the applicable 2024 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2024 Redemption Date) discounted to such 2024 Redemption Date on a semi-annual basis at the Treasury
Rate, as determined by the Independent Investment Banker, plus 12 basis points; 
 plus, in each of the cases of (i) and (ii) above,
accrued and unpaid interest on the 2024 Notes being redeemed to, but excluding, such 2024 Redemption Date. 
 (e) At the
Company’s option, the 2044 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2044 Redemption Date”; any 2017 Redemption Date, 2019 Redemption Date, 2024 Redemption Date or 2044 Redemption Date is
herein referred to as a “Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2044 Redemption Price”; any 2017 Redemption Price, 2019 Redemption Price,
2024 Redemption Price or 2044 Redemption Price is herein referred to as a “Redemption Price”) equal to the greater of the following amounts: 

(i) 100% of the principal amount of the 2044 Notes being redeemed on the relevant 2044 Redemption Date, and 

(ii) the sum of the present values of the remaining scheduled payments of principal and interest on the 2044 Notes being
redeemed on the applicable 2044 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2044 Redemption Date) discounted to such 2044 Redemption Date on a semi-annual basis at the Treasury Rate, as
determined by the Independent Investment Banker, plus 15 basis points; 
 plus, in each of the cases of (i) and (ii) above, accrued and
unpaid interest on the 2044 Notes being redeemed to, but excluding, such 2044 Redemption Date. 
 (f) Notice of any redemption of the Notes
of any series shall be given in the manner and otherwise in accordance with the provisions of Section 1104 of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed
not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall
state the manner in which such Redemption Price shall be calculated. If the Company has given notice of redemption as provided in the Indenture and funds for the redemption of the Notes called for redemption have been made available on the
Redemption Date referred to in that notice, such Notes will cease to bear interest on such Redemption Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such
Redemption Date will be paid as specified in such notice. 

  
 -11- 








 (g) The following defined terms used in this Article Seven shall, unless the context otherwise
requires, have the meanings specified below. 
 “Comparable Treasury Issue” means the United States Treasury security selected by
the Independent Investment Banker as having a maturity comparable to the remaining term of the applicable Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new
issues of corporate debt securities of comparable maturity to the remaining term of such Notes. 
 “Comparable Treasury Price”
means (A) the average of the Reference Treasury Dealer Quotations for the applicable Redemption Date and the applicable Notes to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if
the Independent Investment Banker obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference
Treasury Dealer Quotation. 
 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company
to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Merrill Lynch, Pierce,
Fenner & Smith Incorporated, Barclays Capital Inc., Deutsche Bank Securities Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided,
however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Notes to be
redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case as a percentage of its principal amount) quoted in writing to the
Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

(h) In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or 

  
 -12- 








 
prior to the time of giving of any notice of redemption to the Holders of any Notes to be redeemed, the Company shall deliver an Officers’ Certificate to the Trustee setting forth the
calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may conclusively presume the correctness of, and
shall be fully protected in relying upon, the applicable Redemption Price as so calculated, or the manner in which such Redemption Price shall be calculated, as relevant, and set forth in such Officers’ Certificate. 

Section 702. No Sinking Fund. None of the Floating Rate Notes, the 2017 Notes, the 2019 Notes, the 2024 Notes or the 2044 Notes
are entitled to the benefit of any sinking fund. 
 ARTICLE EIGHT 

FORMS OF NOTES 

Section 801. Form of Floating Rate Note. The Floating Rate Notes and the Trustee’s Certificate of Authentication to be
endorsed thereon are to be substantially in the forms set forth in Exhibit A hereto. 
 Section 802. Form of 2017 Note. The 2017
Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit B hereto. 

Section 803. Form of 2019 Note. The 2019 Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to
be substantially in the forms set forth in Exhibit C hereto. 
 Section 804. Form of 2024 Note. The 2024 Notes and the
Trustee’s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit D hereto. 

Section 805. Form of 2044 Note. The 2044 Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to
be substantially in the forms set forth in Exhibit E hereto. 
 ARTICLE NINE 

ORIGINAL ISSUE AMOUNT OF NOTES 

Section 901. Original Issue Amount of the Floating Rate Notes. Floating Rate Notes in the aggregate principal amount of
$500,000,000 may, upon execution of this Fourth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication and the Trustee shall, upon receipt of a Company Order, authenticate and deliver said Floating Rate
Notes as provided in said Company Order. 

  
 -13- 








 Section 902. Original Issue Amount of the 2017 Notes. 2017 Notes in the aggregate
principal amount of $1,000,000,000 may, upon execution of this Fourth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and
deliver said 2017 Notes as provided in said Company Order. 
 Section 903. Original Issue Amount of the 2019 Notes. 2019 Notes
in the aggregate principal amount of $1,500,000,000 may, upon execution of this Fourth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order,
authenticate and deliver said 2019 Notes as provided in said Company Order. 
 Section 904. Original Issue Amount of the 2024
Notes. 2024 Notes in the aggregate principal amount of $1,000,000,000 may, upon execution of this Fourth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication and the Trustee shall, upon receipt of a
Company Order, authenticate and deliver said 2024 Notes as provided in said Company Order. 
 Section 905. Original Issue Amount of
the 2044 Notes. 2044 Notes in the aggregate principal amount of $500,000,000 may, upon execution of this Fourth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication and the Trustee shall, upon
receipt of a Company Order, authenticate and deliver said 2044 Notes as provided in said Company Order. 
 ARTICLE TEN 

MISCELLANEOUS 

Section 1001. Ratification of Indenture. The Indenture, as supplemented by this Fourth Supplemental Indenture, is in all respects
ratified and confirmed, and this Fourth Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided. 

Section 1002. Trustee Not Responsible for Recitals. The recitals and statements herein contained are made by the Company and not
by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Fourth Supplemental Indenture. 

Section 1003. Governing Law. This Fourth Supplemental Indenture and each Note shall be governed by and construed in accordance
with the laws of the State of New York. 
 Section 1004. Separability. In case any one or more of the provisions contained in
this Fourth Supplemental Indenture or in the Notes shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Fourth Supplemental
Indenture or of the Notes, but this Fourth Supplemental Indenture and the Notes shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein. 

  
 -14- 








 Section 1005. Counterparts. This Fourth Supplemental Indenture may be executed in any
number of counterparts each of which shall be an original; but such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Fourth Supplemental Indenture and of signature pages by facsimile or
electronic format (i.e., “pdf” or “tif”) transmission shall constitute effective execution and delivery of this Fourth Supplemental Indenture as to the parties hereto and may be used in lieu of the original Fourth
Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or electronic format (i.e., “pdf” or “tif”) shall be deemed to be their original signatures for all purposes. 

Section 1006. Trust Indenture Act. This Fourth Supplemental Indenture is subject to the provisions of the Trust Indenture Act that
are required to be part of the Indenture and shall, to the extent applicable, be governed by such provisions. If any provision in this Fourth Supplemental Indenture limits, qualifies or conflicts with another provision of hereof which is required to
be included herein by any provisions of the Trust Indenture Act, such required provision shall control. 

  
 -15- 








 IN WITNESS WHEREOF, the parties hereto have caused this Fourth Supplemental Indenture to be duly executed, all as
of the day and year first above written. 
  

					
	PFIZER INC.
		
	By:	 	 /s/ Brian Byala

		 	Name:	 	Brian Byala
		 	Title:	 	Senior Vice President and Treasurer


  

					
	THE BANK OF NEW YORK MELLON, as Trustee
		
	By:	 	 /s/ Francine Kincaid

		 	Name:	 	Francine Kincaid
		 	Title:	 	Vice President


 [Signature Page to Fourth Supplemental Indenture] 







 EXHIBIT A 

FORM OF FLOATING RATE NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF
A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A
NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 Unless this certificate is presented by an
authorized representative of The Depository Trust Company, a New York corporation (“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of
Cede & Co. or in such other name as is requested by an authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 

PFIZER INC. 
 FLOATING RATE NOTES
DUE 2017 
 CUSIP No. [—] 

No. [—] 

Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [—] DOLLARS ($[—]) on May 15, 2017, and to pay interest thereon from May 15, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, quarterly in arrears on
February 15, May 15, August 15 and November 15, beginning August 15, 2014 at the rate per annum provided below, until the principal hereof is paid or made available for payment. 

The Floating Rate Notes Due 2017 will bear interest at a per annum rate equal to LIBOR, as determined by the Calculation Agent, plus 0.150%.
The Calculation Agent will set the initial interest rate on May 15, 2014 and reset the interest rate on each Interest Payment Date (each such date, an “Interest Reset Date”). The second London business day preceding an Interest Reset
Date will be the “Interest Determination Date” for that Interest Reset Date. The interest rate in effect on each date that is not an Interest Reset Date will be the interest rate determined as of the Interest Determination Date pertaining
to the immediately preceding Interest Reset Date. The interest rate in effect on any day that is an Interest Reset Date will be the interest rate determined as of the Interest Determination Date pertaining to the Interest Reset Date. Interest shall
be computed on the basis of the actual number of days in the relevant interest period and a 360-day year. 
 The interest so payable, and
punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular
Record Date for such interest, which shall be February 1, May 1, August 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so
punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is


  
 A-1 








 
registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this
series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such
notice as may be required by such exchange, all as more fully provided in said Indenture. 
 The Bank of New York Mellon, a New York banking
corporation shall act as calculation agent (together with its successors in that capacity, the “Calculation Agent”) in connection with the Notes. The Calculation Agent shall serve as the calculation agent hereunder unless and until a
successor calculation agent is appointed by the Company. 
 “LIBOR” will be determined by the Calculation Agent in accordance with
the following provisions: 
 (i) With respect to any Interest Determination Date, LIBOR will be the rate for deposits in United States
dollars having a maturity of three months beginning on the first day of the applicable interest period that appears on Reuters Page LIBOR01 as of 11:00 a.m., London time, on that Interest Determination Date. If, on an Interest Determination Date,
such rate does not appear on Reuters Page LIBOR01 as of 11:00 a.m., London time, or if Reuters Page LIBOR01 is not available on such date, the Calculation Agent will obtain such rate from Bloomberg L.P.’s page “BBAM.” If no rate
appears on Reuters Page LIBOR01 or Bloomberg L.P. page BBAM as of approximately 11:00 a.m., London time, on such Interest Determination Date, LIBOR for that Interest Determination Date will be determined in accordance with the provisions described
in (ii) below. 
 (ii) With respect to an Interest Determination Date on which no rate appears on Reuters Page LIBOR01 or Bloomberg
L.P. page BBAM, as specified in (i) above, the Calculation Agent will request the principal London offices of each of four major reference banks in the London interbank market, as selected by the Calculation Agent (after consultation with the
Company), to provide the Calculation Agent with its offered quotation for deposits in United States dollars for the period of three months, commencing on the first day of the applicable interest period, to prime banks in the London interbank market
at approximately 11:00 a.m., London time, on that Interest Determination Date and in a principal amount that is representative for a single transaction in United States dollars in that market at that time. If at least two quotations are provided,
then LIBOR on that Interest Determination Date will be the arithmetic mean of those quotations. If fewer than two quotations are provided, then LIBOR on the Interest Determination Date will be the arithmetic mean of the rates quoted at approximately
11:00 a.m., in The City of New York, on the Interest Determination Date by three major banks in The City of New York selected by the Calculation Agent (after consultation with the Company) for loans in United States dollars to leading European
banks, having a three-month maturity and in a principal amount that is representative for a single transaction in United States dollars in that market at that time. If, however, the banks selected by the Calculation Agent are not providing
quotations in the manner described by the previous sentence, LIBOR determined as of that Interest Determination Date will be LIBOR in effect on that Interest Determination Date. 

“Reuters Page LIBOR01” means the display designated on page LIBOR01 by Reuters Group plc (or such other page as may replace the
LIBOR01 page on that service (or any successor service) or such other service as may be nominated by the British Bankers’ Association for the purpose of displaying London interbank offered rates for U.S. dollar deposits). 

All percentages resulting from any calculation of the interest rate on the Securities will be rounded to the nearest one hundred-thousandth of
a percentage point with five one millionths of a percentage point rounded upwards (e.g., 9.876545% (or .09876545) would be rounded to 9.87655% (or .0987655)), and all dollar amounts used in or resulting from such calculation on the Securities will
be rounded to the nearest cent (with one-half cent being rounded upward). Each calculation of the interest rate on the Securities by the Calculation Agent will (in the absence of manifest error) be final and binding on the Holders of the Securities
and the Company. 

  
 A-2 








 Payment of the principal of (and premium, if any) and interest on this Security will be made at
the office or agency of the Company maintained for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 
 Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions
shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been
executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-3 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
			
	Dated:	 		 	
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	  

		 	Name:
		 	Title:
		
	Dated:	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

			
		 		 	The Bank of New York Mellon, as Trustee
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:


  
 A-4 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the fourth supplemental indenture dated as of May 15, 2014 (herein called the “Indenture”, which then shall have the meaning
assigned to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$500,000,000. 
 This Security is not redeemable prior to Stated Maturity. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain restrictive covenants and
Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 
 If an
Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations
of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount of all series at the time
Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series with respect to which any default under the
Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with respect to such series and its consequences.
The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series, to waive compliance by the Company with
certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer
hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 
 As
provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy
thereunder unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of
this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the
Holders of a majority in principal amount of Securities of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and
offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein.

 No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

  
 A-5 








 As provided in the Indenture and subject to certain limitations therein set forth, the transfer
of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are
payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more
new Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 A-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 
  

(Please insert social security or other identifying number of assignee) 

 
  
  

 
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

							
	Date:	 	  
	 		 	
				
		 		 		 	 
			
	  
	 		 	
	(Signature Guarantee)	 		 	


  
 A-7 








 EXHIBIT B 

FORM OF 2017 NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF
A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A
NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 Unless this certificate is presented by an
authorized representative of The Depository Trust Company, a New York corporation (“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of
Cede & Co. or in such other name as is requested by an authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 

PFIZER INC. 
 1.100% NOTES DUE
2017 
 CUSIP No. [—] 

No. [—] 

Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [—] DOLLARS ($[—]) on May 15, 2017, and to pay interest thereon from May 15, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears,
on May 15 and November 15 in each year, beginning November 15, 2014 at the rate of 1.100% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided
for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest,
which shall be the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted
Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 B-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 B-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
			
	Dated:	 		 	
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	  

		 	Name:
		 	Title:
		
	Dated:	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

			
		 		 	The Bank of New York Mellon, as Trustee
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:


  
 B-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the fourth supplemental indenture dated as of May 15, 2014 (herein called the “Indenture”, which then shall have the meaning
assigned to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,000,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 4 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 B-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Merrill
Lynch, Pierce, Fenner & Smith Incorporated, Barclays Capital Inc., Deutsche Bank Securities Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided,
however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 B-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 B-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 

					
		 	  
	  	
		 	(Please insert social security or other identifying number of assignee)	  	

  

 
  

 
  

 

					
	(Please print or typewrite name and address including postal zip code of assignee)

 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

									
	Date:	 	  
	 		 		 	
					
		 		 		 		 	  

				
	  
	 		 		 	
	(Signature Guarantee)	 		 		 	


  
 B-7 








 EXHIBIT C 

FORM OF 2019 NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME
OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A
NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 Unless this certificate is presented by an
authorized representative of The Depository Trust Company, a New York corporation (“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of
Cede & Co. or in such other name as is requested by an authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 

PFIZER INC. 
 2.100% NOTES DUE
2019 
 CUSIP No. [—] 

No. [—] 

Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [—] DOLLARS ($[—]) on May 15, 2019, and to pay interest thereon from May 15, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears,
on May 15 and November 15 in each year, beginning November 15, 2014 at the rate of 2.100% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided
for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest,
which shall be the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted
Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 C-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 C-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

									
		 		 		 	PFIZER INC.
				
	Dated:	 		 		 	
					
		 		 		 	By:	 	  

		 		 		 		 	Name:
		 		 		 		 	Title:
					
	Attest:	 	  
	 		 		 	
		 	Name:	 		 		 	
		 	Title:	 		 		 	
					
	Dated:	 		 		 		 	
		 		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

				
		 		 		 	The Bank of New York Mellon, as Trustee
					
		 		 		 	By:	 	  

		 		 		 		 	Name:
		 		 		 		 	Title:


  
 C-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the fourth supplemental indenture dated as of May 15, 2014 (herein called the “Indenture”, which then shall have the meaning
assigned to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,500,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 7 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 C-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Merrill
Lynch, Pierce, Fenner & Smith Incorporated, Barclays Capital Inc., Deutsche Bank Securities Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided,
however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 C-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 C-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 

					
		 	  
	  	
		 	(Please insert social security or other identifying number of assignee)	  	

  

 
  

 
  

 

					
	(Please print or typewrite name and address including postal zip code of assignee)

 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

									
	Date:	 	  
	 		 		 	
					
		 		 		 		 	  

				
	  
	 		 		 	
	(Signature Guarantee)	 		 		 	


  
 C-7 








 EXHIBIT D 

FORM OF 2024 NOTE 
 THIS SECURITY
IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF
THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

Unless this certificate is presented by an authorized representative of The Depository Trust Company, a New York corporation
(“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as is requested by an authorized representative of
DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the
registered owner hereof, Cede & Co., has an interest herein. 
 PFIZER INC. 

3.400% NOTES DUE 2024 
 CUSIP No. [—] 
 No. [—] 

Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [—] DOLLARS ($[—]) on May 15, 2024, and to pay interest thereon from May 15, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears,
on May 15 and November 15 in each year, beginning November 15, 2014 at the rate of 3.400% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided
for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest,
which shall be the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted
Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 D-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 D-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

									
		 		 		 	PFIZER INC.
				
	Dated:	 		 		 	
					
		 		 		 	By:	 	  

		 		 		 		 	Name:
		 		 		 		 	Title:
					
	Attest:	 	  
	 		 		 	
		 	Name:	 		 		 	
		 	Title:	 		 		 	
					
	Dated:	 		 		 		 	
		 		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

				
		 		 		 	The Bank of New York Mellon, as Trustee
					
		 		 		 	By:	 	  

		 		 		 		 	Name:
		 		 		 		 	Title:


  
 D-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the fourth supplemental indenture dated as of May 15, 2014 (herein called the “Indenture”, which then shall have the meaning
assigned to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,000,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 12 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker


  
 D-4 








 
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is
received, such Reference Treasury Dealer Quotation. 
 “Independent Investment Banker” means one of the Reference Treasury Dealers
appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of
Merrill Lynch, Pierce, Fenner & Smith Incorporated, Barclays Capital Inc., Deutsche Bank Securities Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors;
provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 D-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 D-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 

					
		 	  
	  	
		 	(Please insert social security or other identifying number of assignee)	  	

  

 
  

 
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

 
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

							
	Date:	 	  
	 		 	
				
		 		 		 	 
			
	  
	 		 	
	(Signature Guarantee)	 		 	


  
 D-7 








 EXHIBIT E 

FORM OF 2044 NOTE 
 THIS SECURITY
IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF
THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

Unless this certificate is presented by an authorized representative of The Depository Trust Company, a New York corporation
(“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as is requested by an authorized representative of
DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the
registered owner hereof, Cede & Co., has an interest herein. 
 PFIZER INC. 

4.400% NOTES DUE 2044 
 CUSIP No. [—] 
 No. [—] 

Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes
any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [—] DOLLARS ($[—]) on May 15, 2044, and to pay interest thereon from May 15, 2014 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears,
on May 15 and November 15 in each year, beginning November 15, 2014 at the rate of 4.400% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided
for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest,
which shall be the May 1 or November 1 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable
to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted
Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 E-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 E-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
				
	Dated:	 		 		 	
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	  

		 	Name:
		 	Title:
		
	Dated:	 	

  

			
	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.

	
	The Bank of New York Mellon, as Trustee
		
	By:	 	  

		 	Name:
		 	Title:



  
 E-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities), issued and to be issued in
one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the fourth supplemental indenture dated as of May 15, 2014 (herein called the “Indenture”, which then shall have the meaning assigned to it in
such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the “Trustee”, which
term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of
the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to $500,000,000. 

At the Company’s option, the Securities of this series may be redeemed in whole or in part, at any time and from time to time (each, a
“Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 15 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable
Redemption Price. 
 Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions
of Section 1104 of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of
Securities to be redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has
given notice of redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on
such Redemption Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker


  
 E-4 








 
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is
received, such Reference Treasury Dealer Quotation. 
 “Independent Investment Banker” means one of the Reference Treasury Dealers
appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of
Merrill Lynch, Pierce, Fenner & Smith Incorporated, Barclays Capital Inc., Deutsche Bank Securities Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors;
provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 E-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
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 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 

					
		 	  
	  	
		 	(Please insert social security or other identifying number of assignee)	  	

  

 
  

 
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

							
	Date:	 	  
	 		 	
				
		 		 		 	 
			
	  
	 		 	
	(Signature Guarantee)	 		 	


  
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