ctix_ex1037.htm


EXHIBIT 10.37


 


Intellectual Property Acquired from Polymedix







The intellectual property portfolio of the former Polymedix which we acquired consists of the following:







CATAGORIES


 



	
1.

	
Brilacidin, and related compounds








	
2.

	
Delparantag and related compounds








	
3.

	
Anti-microbial- surfactants and related compounds







 



	
Patent

	
Status

	
Description


	
COMPOSITION AND USE PATENTS


	
Design, preparation and properties of antibacterial beta-peptides. (1)

	
United States - Issued 01/13/04


Category: 1


Patent expires: 2020

	
This patent claims composition of matter for particular beta-peptides that have antibacterial properties.  It also claims pharmaceutical preparations containing particular antibacterial beta-peptides and methods for creating sanitizing surfaces by treatment with an antibacterial beta-peptide.


	
Amphiphilic Polymers as Anti-Infective Agents: 1 (1)


 

	
United States – filed


Patent Cooperation Treaty – filed


National Phase entered


United States - issued 02/06/2007


European Patent - issued 09/17/2008


Other issued patents include Australia, China, Japan, South Korea


 


Category: 1 & 3


Patents expire: 2022

	
These patents and application family claims composition of matter for facially amphiphilic polymers that are polyamides, polyesters, polyurea, polyurethane, polycarbonate, or polyphenylene, compounds.  Also claimed are material articles made from the amphiphilic polymers that have antimicrobial properties.


 


	
Amphiphilic Polymers as Anti-Infective Agents: 2 (Phenylalkynes) (1)


 

	
United States – filed


 


Patent Cooperation Treaty – filed


 


National Phase entered


 


European Patent - issued 05/25/2011


 


Other issued patents: Australia, South Korea


 


European Divisional filed


 


Other divisional filings: Japan, China


 


Category: 1 & 3


Patents expire: 2022

	
These patents are similar to “Amphiphilic Polymers as Anti-Infective Agents: 1” above, but further claims facially amphiphilic polymers that are polyphenylene and heteroarylene compounds.


 


 


	
Facially amphiphilic polymers and oligomers and uses thereof: 1 (1)


 

	
United States – filed


Patent Cooperation Treaty - filed


National Phase entered


 


Other issued patents: Australia


 


United Stated Divisional – issued 08/07/2012


 


European Divisionals – four filed


 


Other Divisional filings: Australia, China, Japan


 


Category: 1 & 2


Patents expire: 2024

	
This application claims pharmaceutical compositions and uses for facially amphiphilic polymers, oligomers and small molecules that are polyamides, polyesters, polyurea, polyurethane, polycarbonate, or polyphenylene, compounds.  Uses include method of treatment (systemic and topical) as antimicrobial agents against bacteria, fungi and viruses and as an antidote to heparin and LMWH.  Also, composition of matter claims are expanded.


 







 




  





1











  












	
Patent

	
Status

	
Description


	
Facially amphiphilic polymers and oligomers and uses thereof: 2 (Phenylalkynes) (1)

	
United States – filed


Patent Cooperation Treaty - filed


National Phase entered


 


United States patent issued 07/17/2012


 


Other issued patents: Australia


 


United States Divisional – filed


 


European Divisional - filed


 


Other Divisional filings: China, South Korea


 


Category: 1 & 3


Patents expire: 2024

	
These patents are similar to “Amphiphilic Polymers as Anti-Infective Agents: 1” above, except that the small molecules to which it claims use are polyphenylene and heteroarylene compounds.


 


	
Polycationic Compounds and Uses thereof


 

	
United States – filed


 


Patent Cooperation Treaty – filed


 


National Phase entered


 


United States patent issued 06/30/2009


 


European Patent issued 08/07/13


 


Australia Patent issued 05/17/12


 


China Patent Issued 08/22/12


 


South Korea Patent issued 08/03/12


 


United States Continuations –  five filed: four issued 06/29/10; 03/06/12; 07/31/12; 08/13/13; one pending


 


Other Divisional filings: Japan, China


 


South Korea Divisional issued 06/26/12


 


Category: 2


Patents expire: 2025

	
This application claims method of use for modulating angiogenesis with polycationic compounds, compositions of anti-heparin compounds and methods of inhibiting heparin activity.


 


	
Composition and Use of Polymethacrylate Co-Polymers (1)


 

	
United States – filed


Patent Cooperation Treaty - filed


National Phase entered


Australian Patent issued


European Divisionals - three filed


 


Category: 3


Patents expire: 2025

	
This application claims amphiphilic co-polymers that exhibit antimicrobial activity and uses in a number of pharmaceutical and material applications.


 







 




  





2











  













	
Patent

	
Status

	
Description


	
Ophthalmic and Otic Compositions of Facially Amphiphilic Polymers and Oligomers and Use Thereof

	
United States – filed


Patent Cooperation Treaty - filed


National Phase entered


 


Other patents issued: China


 


Other divisional filings: China


 


Category: 1


Patents expire: 2027

	
This application relates to antimicrobial compositions of facially amphiphilic antimicrobial polymers and oligomers useful for the treatment or prevention of ophthalmic and otic infections.  The application also relates to methods of using the compositions for treating and/or preventing ophthalmic and otic infections.


	
Combination of Synthetic Antimicrobial Polymers and Sesquiterpenoid Compounds


 

	
United States – filed


 


Category: 3


Patents expire: 2028

	
This application relates to the combination of facially amphiphilic antimicrobial polymers and oligomers with sesquiterpenoids to enhance antimicrobial activities.


 


	
Anti-Malarial  Compounds

	
United States – filed


Patent Cooperation Treaty - filed


National Phase entered


 


Category: 1


Patents expire: 2029

	
This application relates in to arylamide and other classes of compounds and their use in treating malaria.


 


	
Synthetic Mimetics of Host Defense and Uses Thereof

	
United States – issued 10/02/12


United States Continuation filed


Patent Cooperation Treaty - filed


National Phase entered


 


Category: 1


Patents expire: 2029

	
This application relates to arylamide compounds, their antimicrobial uses and methods of synthesis.


 


	
Antimicrobial Molecules for Treating Multi-Drug Resistant and Extensively-Drug Resistant Strains of Mycobacterium

	
United States - filed


Patent Cooperation Treaty - filed


National Phase entered


 


Category: 1


Patents expire: 2029

	
This application relates to treating multi-drug resistant and extremely drug resistant strains of mycobacterium with antimicrobial compounds and compositions.


 


	
Processes for Preparing a Polymeric Compound


 

	
United States – issued 01/15/13


United States Continuation filed


Mexican Patent issued 06/06/13


Patent Cooperation Treaty – filed


 


Category: 2


Patents expire: 2030

	
This application relates to preferred methods for synthesizing and preparing pharmaceutical compositions of representative compounds in the salicylamide class of compounds


	
Anti-Heparin Compounds


 

	
United States – filed


Patent Cooperation Treaty – filed


National Phase entered


 


Category: 2


Patents expire: 2031

	
This application relates to methods of antagonizing anticoagulant agents, such as unfractionated heparin, low molecular weight heparin, and/or a derivatives and compositions of the antagonists.


	
Methods of Immune Modulation


 

	
United States - filed


Patent Cooperation Treaty – filed


National Phase entered


 


Category: 1


Patents expire: 2031

	
The present invention is directed, in part, to methods of modulating an immune response in an animal with facially amphiphilic compounds.







 




  





3











  






 



	
Patent

	
Status

	
Description


	
Facially Amphiphilic Compounds, Compositions, and Uses Thereof


in Treating Cancer

	
United States - filed


Patent Cooperation Treaty – filed


This entire family was abandoned


 


Category: 1


Patents expire: 2031

	
The present invention relates to compositions of facially amphiphilic compounds and their use in methods for treating cancers in animals, such as humans.


	
Compounds For Use in Treatment of Mucositis

	
United States – filed


Patent Cooperation Treaty – filed


National Phase due 11/13


 


Category: 1


Patents expire: 2032

	
The application relates to methods of treating and/or preventing mucositis.


	
Hybrid Compounds and Methods of Making and Using the Same

	
United States provisional filed


 


Category: 1

	
The application relates to compositions and use of anti-microbial compounds.


	
Polycyclic Compounds and Methods of Making and Using the Same

	
United States provisional filed


 


Category: 1

	
The application relates to compositions and use of anti-microbial compounds.


	
Antagonizing Heparin with Salicylamide Compounds and Histamine Blocking Agents

	
United States provisional filed


 


Category: 2

	
The application relates to use of anti-heparin salicylamide compounds with histamine blocking agents to treat cardiovascular disorders.


	
Compounds and Methods for Treating Candidiasis and Aspergillus Infections

	
United States – filed


Patent Cooperation Treaty – filed


National Phase due 07/14


 


Category: 1


Patents expire: 2033

	
The application relates to compositions and use of anti-fungal compounds.


	
Compounds and Methods for Treating Malaria

	
Patent Cooperation Treaty – filed


National Phase due 08/14


 


Category: 1


Patents expire: 2033

	
The application relates to compositions and use of anti-malarial compounds.


	
Compositions of Arylamide Compounds and Antimicrobial Agents

	
United States provisional filed


Category: 1

	
The application relates to compositions and use of arylamide compounds and anti-microbial agents.


	
COMPUTATIONAL PATENTS


	
Methods, systems and computer program products for computational analysis and design of amphiphilic polymers (1)

	
United States - issued 09/15/2009


 


Patents expire: 2022

	
This application is directed to the creation and use of novel force field packages for modeling the structure and behavior of complex molecules in complex environments.  Specific utilities are the prediction of oligomer structures in polar and apolar medias.










	
Computer simulation of biomembranes using a Coarse Grain Model (1)


 

	
United States – filed


 


Patents expire: 2022

	
This application is directed to the creation and use of a novel coarse grain model for studying complex biological structures, such as membranes.  Specifically a computational approach is described that accurately predicts the structural and dynamic properties of membranes that are far less demanding of CPU time than comparable methods.


	
Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel Kcsa (1)

	
United States – filed


 


Patents expire: 2022

	
This application claims methods and computer programs for the computational design of water-soluble analogs of membrane proteins that retain biological function.


 













	  	
(1)

	
Patent rights obtained pursuant to a license agreement with the University of Pennsylvania.













In addition, we have trademark protection for the marks PolyMedix,® PolyCide®, and PolyDentix®.


 




  





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