II 

110TH CONGRESS 

1ST SESSION S. 1398 

To expand the research and prevention activities of the National Institute 

of Diabetes and Digestive and Kidney Diseases, and the Centers for 

Disease Control and Prevention with respect to inflammatory bowel disease. 

IN THE SENATE OF THE UNITED STATES 

MAY 15, 2007 

Mr. REID (for himself and Mr. COCHRAN) introduced the following bill; which 

was read twice and referred to the Committee on Health, Education, 

Labor, and Pensions 

A BILL 

To expand the research and prevention activities of the National Institute of Diabetes and Digestive and Kidney 

Diseases, and the Centers for Disease Control and Prevention with respect to inflammatory bowel disease. 

1 Be it enacted by the Senate and House of Representa2 tives of the United States of America in Congress assembled, 

3 SECTION 1. SHORT TITLE. 

4 This Act may be cited as the ‘‘Inflammatory Bowel 

5 Disease Research Enhancement Act’’. 

6 SEC. 2. FINDINGS. 

7 Congress makes the following findings: 


hmoore on PRODPC68 with HMBILLS
2 

•S 1398 IS

1 (1) Crohn’s disease and ulcerative colitis are se2 rious inflammatory diseases of the gastrointestinal 

3 tract. 

4 (2) Crohn’s disease may occur in any section of 

5 the gastrointestinal tract but is predominately found 

6 in the lower part of the small intestine and the large 

7 intestine. Ulcerative colitis is characterized by in8 flammation and ulceration of the innermost lining of 

9 the colon. Complete removal of the colon in patients 

10 with ulcerative colitis can potentially alleviate and 

11 cure symptoms. 

12 (3) Because Crohn’s disease and ulcerative coli13 tis behave similarly, they are collectively known as 

14 inflammatory bowel disease. Both diseases present a 

15 variety of symptoms, including severe diarrhea, ab16 dominal pain with cramps, fever, and rectal bleeding. 

17 There is no known cause of inflammatory bowel dis18 ease, or medical cure. 

19 (4) It is estimated that up to 1,400,000 people 

20 in the United States suffer from inflammatory bowel 

21 disease, 30 percent of whom are diagnosed during 

22 their childhood years. 

23 (5) Children with inflammatory bowel disease 

24 miss school activities because of bloody diarrhea and 

25 abdominal pain, and many adults who had onset of 


hmoore on PRODPC68 with HMBILLS
3 

•S 1398 IS

1 inflammatory bowel disease as children had delayed 

2 puberty and impaired growth and have never 

3 reached their full genetic growth potential. 

4 (6) Inflammatory bowel disease patients are at 

5 high risk for developing colorectal cancer. 

6 SEC. 3. NATIONAL INSTITUTE OF DIABETES AND DIGES7 TIVE AND KIDNEY DISEASES; INFLAMMATORY 

8 BOWEL DISEASE RESEARCH EXPANSION. 

9 Subpart 3 of part C of title IV of the Public Health 

10 Service Act (42 U.S.C. 285c et seq.) is amended by adding 

11 at the end the following: 

12 ‘‘SEC. 434B. INFLAMMATORY BOWEL DISEASE. 

13 ‘‘(a) IN GENERAL.—The Director of the Institute 

14 shall expand, intensify, and coordinate the activities of the 

15 Institute with respect to research on inflammatory bowel 

16 disease. Such research may be focused on, but not limited 

17 to, the following areas: 

18 ‘‘(1) Genetic research on susceptibility for in19 flammatory bowel disease, including the interaction 

20 of genetic and environmental factors in the develop21 ment of the disease. 

22 ‘‘(2) Research targeted to increase knowledge 

23 about the causes and complications of inflammatory 

24 bowel disease in children. 


hmoore on PRODPC68 with HMBILLS
4 

•S 1398 IS

1 ‘‘(3) Animal model research on inflammatory 

2 bowel disease, including genetics in animals. 

3 ‘‘(4) Clinical inflammatory bowel disease re4 search, including clinical studies and treatment 

5 trials. 

6 ‘‘(5) Expansion of the Institute’s Inflammatory 

7 Bowel Disease Centers program with a focus on pe8 diatric research. 

9 ‘‘(6) The training of qualified health profes10 sionals in biomedical research focused on inflam11 matory bowel disease, including pediatric investiga12 tors. 

13 ‘‘(7) Other research priorities identified by the 

14 scientific agendas ‘Challenges in Inflammatory 

15 Bowel Disease Research’ (Crohn’s and Colitis Foun16 dation of America) and ‘Chronic Inflammatory 

17 Bowel Disease’ (North American Society for Pedi18 atric Gastroenterology, Hepatology and Nutrition). 

19 ‘‘(b) AUTHORIZATION OF APPROPRIATIONS.—To 

20 carry out subsection (a), there are authorized to be appro21 priated $80,000,000 for fiscal year 2008, $90,000,000 for 

22 fiscal year 2009, and $100,000,000 for fiscal year 2010.’’. 


hmoore on PRODPC68 with HMBILLS
5 

•S 1398 IS

1 SEC. 4. CENTERS FOR DISEASE CONTROL AND PREVEN2 TION; EXPANSION OF INFLAMMATORY BOWEL 

3 DISEASE EPIDEMIOLOGY PROGRAM. 

4 Part A of title III of the Public Health Service Act 

5 (42 U.S.C. 241 et seq.) is amended by adding at the end 

6 the following: 

7 ‘‘SEC. 310A. CENTERS FOR DISEASE CONTROL AND PREVEN8 TION; EXPANSION OF INFLAMMATORY BOWEL 

9 DISEASE EPIDEMIOLOGY PROGRAM. 

10 ‘‘(a) IN GENERAL.—Not later than 1 year after the 

11 date of enactment of this Act, the Director of the Centers 

12 for Disease Control and Prevention shall expand the In13 flammatory Bowel Disease Epidemiology Program within 

14 the National Center for Chronic Disease Prevention and 

15 Health Promotion to include additional studies focused 

16 on— 

17 ‘‘(1) the incidence and prevalence of pediatric 

18 inflammatory bowel disease in the United States; 

19 ‘‘(2) genetic and environmental factors associ20 ated with pediatric inflammatory bowel disease; 

21 ‘‘(3) age, race or ethnicity, gender, and family 

22 history of individuals diagnosed with pediatric in23 flammatory bowel disease; and 

24 ‘‘(4) treatment approaches and outcomes in pe25 diatric inflammatory bowel disease. 


hmoore on PRODPC68 with HMBILLS
6 

•S 1398 IS

1 ‘‘(b) CONSULTATION.—The Director shall carry out 

2 subsection (a) in consultation with a national voluntary 

3 patient organization with experience serving the popu4 lation of individuals with pediatric inflammatory bowel 

5 disease and organizations representing physicians and 

6 other health professionals specializing in the treatment of 

7 such populations. 

8 ‘‘(c) AUTHORIZATION OF APPROPRIATIONS.—To 

9 carry out this section, there are authorized to be appro10 priated $5,000,000 for fiscal year 2008, and such sums 

11 as may be necessary for each of fiscal years 2009 and 

12 2010.’’. 

Æ 


hmoore on PRODPC68 with HMBILLS