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                            STOCK PURCHASE AGREEMENT


         THIS STOCK PURCHASE AGREEMENT is made as of the 8th day of March, 2000,
by and between Medical Advisory Systems, Inc. (the "Seller"), a Delaware
corporation; and Premier Research Worldwide, Ltd. (the "Buyer"), a Delaware
corporation. The Seller and the Buyer are referred to herein collectively as the
"Parties."

                                    Recitals:

         The Seller wishes to sell to the Buyer, and the Buyer wishes to
purchase from the Seller, 550,000 shares of the Seller's Common Stock, par value
$.005 (the "Common Stock"), in accordance with the terms and provisions of this
Agreement.

         The Seller's Common Stock is registered under the Securities Exchange
Act of 1934 (the "Exchange Act") and listed on the NASDAQ/AMEX.

         NOW, THEREFORE, the Parties hereto, intending to be legally bound
hereby, agree as follows:

         1.       Definitions.

                  "Accredited Investor" has the meaning set forth in Regulation
D promulgated under the Securities Act.

                  "Adverse Consequences" means all actions, suits proceedings,
hearings, investigations, charges, complaints, claims, demands, injunctions,
judgments, orders, decrees, rulings, damages, dues, penalties, fines, costs,
amounts paid in settlement, Liabilities, obligations, Taxes, liens, losses,
expenses, and fees, including court costs and reasonable attorneys' fees and
expenses.

                  "Affiliate" has the meaning set forth in Rule 12b-2 of the
regulations promulgated under the Exchange Act.

                   "Audit" means any audit, assessment or other examination
relating to Taxes by any Tax Authority or any judicial or administrative
proceedings relating to Taxes.

                  "COBRA" means the requirements of Part 6 of Subtitle I of
ERISA and Code Section 4980B.

                  "Code" means the Internal Revenue Code of 1986, as amended.

                  "Environmental Laws" shall mean all federal, state, local and
foreign statutes, regulations, ordinances and other provisions having the force
and effect of laws, all judicial and administrative orders and determinations,
all contractual obligations and all common law concerning pollution or

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protection of the environment, or the impact of the environment on human health,
including without limitation all those relating to the presence, use,
production, generation, handling, transportation, treatment, storage, disposal,
distribution, labeling, testing, processing, discharge, release, threatened
release, control, or cleanup of any hazardous materials, substances or wastes,
chemical substances or mixtures, pesticides, pollutants, contaminants, toxic
chemicals, petroleum products or byproducts, asbestos, polychlorinated
biphenals, noise or radiation, each as amended and as now or hereafter in
effect.

                  "ERISA" means the Employee Retirement Income Security Act of
1974, as amended.

                  "eRT" means eResearch Technology, Inc., a wholly owned
subsidiary of the Buyer.

                  "GAAP" means United States generally accepted accounting
principles as in effect from time to time.

                  "Health and Safety Requirements" shall mean all federal,
state, local and foreign statutes, regulations, ordinances and other provisions
having the force and effect of laws, all judicial and administrative orders and
determinations, all contractual obligations and all common law concerning public
health and safety, and worker health and safety, including without limitation
all those relating to the presence, use, production, generation, handling,
transportation, treatment, storage, disposal, distribution, labeling, testing,
processing, discharge, release, threatened release, control, or cleanup of any
hazardous materials, substances or wastes, chemical substances or mixtures,
pesticides, pollutants, contaminants, toxic chemicals, petroleum products or
byproducts, asbestos, polychlorinated biphenals, noise or radiation, each as
amended and as now or hereafter in effect.

                  "Knowledge" means actual knowledge.

                  "Liability" means any liability (whether known or unknown,
whether asserted or unasserted, whether absolute or contingent, whether accrued
or unaccrued, whether liquidated or unliquidated, and whether future or become
due), including any liability for Taxes.

                  "License Agreement" means the Master Software License
Agreement between eRT and the Seller.

                  "Ordinary Course of Business" means the ordinary course of
business consistent with past custom and practice (including with respect to
quantity and frequency).

                  "PBGC" means the Pension Benefit Guaranty Corporation.

                  "Person" means an individual, a partnership, a corporation, an
association, a joint stock company, a trust, a joint venture, an unincorporated
organization, or a governmental entity (or any department, agency, or political
subdivision thereof).

                  "SEC" means the United States Securities and Exchange
Commission.

                  "Securities Act" means the Securities Act of 1933, as amended.


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                  "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

                  "Security Interest" means any mortgage, pledge, lien,
encumbrance, charge or other security interest, other than (a) liens for Taxes
not yet due and payable, (b) purchase money liens and liens securing rental
payments under capital lease arrangements, and (c) other liens arising in the
Ordinary Course of Business and not incurred in connection with the borrowing of
money.

                  "Service Agreement" means Service, Sales and Co-Marketing
Agreement dated as of April 1, 2000 between Buyer's wholly owned subsidiary, eRT
and the Seller.

                  "Tax" means any federal, state, local or foreign, income,
gross receipts, license, payroll, employment, excise, severance, stamp,
occupation, premium, windfall profits, environmental (including taxes under Code
Section 59A), custom duties, capital stock, franchise, profits, withholding,
social security (or similar), unemployment, disability, real property, personal
property, sales, use, transfer, registration, value added, alternative or add-on
minimum, estimated, or other tax of any kind whatsoever, including any interest,
penalty, or addition thereto, whether disputed or not.

                  "Tax Authority" means the Internal Revenue Service and any
other domestic or foreign governmental authority responsible for the
administration of any Taxes.

                  "Tax Return" means any return, declaration, report, claim for
refund, or information return or statement relating to Taxes, including any
schedule or attachment thereto, and including any amendment thereof required to
be filed with any Tax Authority.

         2.       Purchase and Sale; Use of Proceeds.

                  (a) Number of Shares. The Seller is selling to the Buyer, and
the Buyer is purchasing from the Seller, 550,000 shares of the Seller's Common
Stock, representing, upon completion of the transaction, approximately 11.1% of
the Seller's issued and outstanding Common Stock. The shares being purchased and
sold pursuant to this Agreement are hereinafter sometimes referred to
individually as a "Share" and collectively as the "Shares."

                  (b) Purchase Price. The aggregate purchase price for the
Shares (the "Purchase Price") shall be $5,775,000. The Buyer agrees to pay the
Seller the Purchase Price in cash payable by wire transfer or delivery of other
immediately available funds.

                  (c) Use of Proceeds. Seller shall use the proceeds from the
sale of the Shares as follows: (i) $2,700,000 under the License Agreement; (ii)
for infrastructure agreed upon in the Service Agreement ; and (iii) the balance
for working capital and other corporate purposes.


         3.       Right of First Refusal.

                  (a) Grant. Commencing on the Closing Date, the Buyer,
including its assignees, and any of its majority owned subsidiaries and its


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assignees, is hereby granted the right of first refusal (the "First Refusal
Right") as set forth in this Section 3. In the event that a third party or group
seeks to acquire the Seller or substantially all of Seller's business or assets
by tender offer, merger, asset sale, stock sale or purchase, or other business
combination (collectively, referred to as a "Sale Event"), which MAS has deemed
an acceptable offer (the "Sale Offer") as determined by Board of Directors of
MAS, the Buyer shall have the right to acquire the Seller, or such portion, as
the case may be, in accordance with the terms of the Sale Offer, as more fully
described in 3(c) hereof This First Refusal Right shall terminate and expire at
the close of business on September 15, 2000.

                  (b) Notice of a Sale Offer. In the event of a Sale Offer, the
Seller shall promptly notify the Buyer, in writing, of the terms of the Sale
Offer, including the purchase price, the other material terms of the transaction
and the identity of the third party offeror (the "Notice of Offer"). The date
that the Buyer receives the Notice of Offer is hereafter defined as the "Notice
Date."

                  (c) Exercise of First Refusal Right. Buyer shall have the
First Refusal Right with respect to a Sale Offer. Buyer shall have thirty (30)
calendar days commencing on the calendar day following receipt of Buyer of the
Notice of Offer within which to inform Seller in writing that it exercises its
First Refusal Right and will enter into the Sale Event on substantially similar
structural terms and economic conditions as set forth in the Notice of Offer. In
the event Buyer notifies Seller of its exercise of its First Refusal Right for a
Sale Event, Buyer and Seller shall cooperate in good faith in negotiating and
executing customary definitive documentation and in taking such other action as
is reasonably necessary and customary to consummate the Sale Event on the same
terms and conditions as set forth in the Notice of Offer.

                  (d) Non-Exercise of the First Refusal Right. In the event (i)
the Seller does not deliver the Exercise Notice to the Seller prior to the
expiration of the 30-day exercise period Buyer's First Refusal Right shall
terminate and be of no further force and effect with respect to the Sale Event
which is the subject of the Notice of Offer, but will remain in effect with
respect to any other Sale Event, including any material modification of a Sale
Event which is the subject of a Notice of Offer with respect to which Buyer
previously elected not to exercise its First Refusal Right.
         4.       Closing.

                  (a) The Closing. The closing of the purchase of the Shares
contemplated by this Agreement (the "Closing") shall take place at the office of
the Buyer, on March 21, 2000, or at such other place, time and date as the Buyer
and the Seller may mutually determine (the "Closing Date").

                  (b) Deliveries at the Closing. At Closing:

                           (i) Seller shall deliver to the Buyer a certificate
of most recent practicable date as to the corporate good standing of Seller
issued by the Secretary of State of Delaware;

                           (ii) Seller shall deliver to Buyer a certified copy
of its Articles of Incorporation and Bylaws and resolutions of its Board of
Directors authorizing and approving all matters in connection with the Agreement
and the transactions contemplated thereby;

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                           (iii) Seller's counsel shall deliver to Buyer an
opinion in the form and substance acceptable to the Buyer and its counsel, dated
as of the Closing Date;

                           (iv) Seller and eRT shall execute and deliver the
Licensing Agreement;

                           (v) Seller and eRT shall execute and deliver the
Services Agreement;

                           (vi) Seller shall deliver to Buyer one certificate
representing the Shares; and

                           (vii) Buyer shall deliver the consideration specified
in Section 2(b) above.

         5. Representations and Warranties of the Seller. Subject to the
disclosures set forth on Seller's disclosure schedule, dated as of the date
hereof and delivered herewith ("Seller Disclosure Schedule"), Seller represents
and warrants to the Buyer as set forth in this Section 5. The inclusion of
information on Seller's Disclosure Schedule shall be deemed adequate to disclose
an exception to a representation or warranty made therein if the information
contained thereon would provide notice to a reasonable person of the existence
of a fact or circumstance which would be contrary to the substance of the
applicable representation and/or warranty. Subject to the foregoing, Seller
represents and warrants to the Buyer as follows:

                  (a) Validity of Issuance. The Shares being sold by the Seller
hereunder have been duly authorized, and, upon the issuance of such Shares to
the Buyer in accordance with the terms and provisions of this Agreement, such
Shares will be validly issued, fully paid and nonassessable.

                  (b) Organization, Qualification and Corporate Power. The
Seller (i) is a corporation duly organized, validly existing and in good
standing under the laws of the jurisdiction of its incorporation, (ii) has the
corporate power and authority to own its property and assets and to transact the
business in which it is engaged and (iii) is duly authorized to conduct business
and is in good standing under the laws of each jurisdiction where such
qualification is required except where any failure to be so qualified would not
have a material adverse effect either individually or in the aggregate on
Seller. The Seller has full corporate power and authority and all licenses,
permits and authorizations necessary to carry on the business in which it is
engaged and to own and use the properties owned and used by it. The Seller has
delivered to the Buyer correct and complete copies of its certificate of
incorporation and bylaws. The minute books (containing the records of meetings
of the stockholders, the board of directors and any committees of the board of
directors), the stock certificate books, and the stock record books of the
Seller are complete, correct and accurate.

                  (c) Authorization, Validity and Effect. The Seller has the
requisite corporate power to execute, deliver and perform the terms and
provisions of this Agreement and has taken all necessary corporate action to
authorize the execution, delivery and performance of this Agreement by the
Seller. This Agreement constitutes, and all agreements and documents described
herein (when executed and delivered pursuant hereto for value received) will


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constitute, the valid and binding obligations of Seller enforceable in
accordance with their respective terms, subject to applicable bankruptcy,
insolvency, moratorium or other similar laws relating to creditor's rights and
general principles of equity.

                  (d) No Consent Required. No authorization, consent or approval
of, or exemption by, any governmental or public body or authority is required to
authorize, or is required in connection with, the execution, delivery and
performance of any of this Agreement, or the taking of any action contemplated
hereby, by the Seller, except such authorizations, consents or approvals which
the failure of Seller to obtain will not either individually or in the aggregate
have a material adverse affect on the financial condition or results of
operations of Seller.

                  (e) No Defaults. No material default exists under any
agreement to which the Seller is a party or by which it is bound, which default,
if not cured, would have a material adverse effect upon the financial condition
or the results of operations of the Seller.

                  (f) No Violation. Neither the execution and delivery of this
Agreement, nor compliance with any of the terms and provisions hereof, nor the
consummation of any of the transactions herein contemplated will: (i) violate
any law, statute, regulation, rule, order, writ, injunction, judgment, ruling,
charge, decree or other restriction of any court or governmental department,
commission, board, bureau, agency or instrumentality applicable to the Seller,
or (ii) conflict or be inconsistent with, or result in any breach of, any of the
terms, covenants, conditions or provisions of, or constitute a default under, or
result in the creation or imposition of (or the obligation to create or impose)
any lien, charge or encumbrance upon any of the property or assets of the Seller
pursuant to the terms of any indenture, mortgage, deed of trust, agreement or
other instrument, or result in the acceleration of, create any notice under any
agreement, contract, lease, license, instrument, or other arrangement to which
the Seller is a party or by which it may be bound or to which it may be subject,
or (iii) violate any provision of any of the organizational documents of the
Seller, including but not limited to its certificate of incorporation and
bylaws.

                  (g) Capitalization. The total number of shares of capital
stock the Seller is authorized to issue is 11,000,000 shares, consisting of
10,000,000 shares of Common Stock and 1,000,000 shares of Preferred Stock having
a par value of $1.75 per share (the "Preferred Stock"). As of Closing Date
4,506,240 shares of Common Stock were issued; outstanding and 50,000 shares of
Common Stock were held in Treasury; and options to purchase an aggregate of
550,000 were outstanding. As of the Closing Date, none of the shares of
Preferred Stock are issued or outstanding.

         All of the issued and outstanding shares of Common Stock of the Seller
have been duly authorized, are validly issued, fully paid, and nonassessable,
and are held of record by 174 Seller's Disclosure Schedule, there are no
outstanding or authorized options, warrants, purchase rights, subscription
rights, conversion rights, exchange rights, or other contracts or commitments
that could require the Seller to issue, sell or otherwise cause to become
outstanding any of its capital. There are no outstanding or authorized stock
appreciation, phantom stock, profit participation or similar rights with respect
to the Seller. There are no voting trusts, proxies or other arrangements or
understandings with respect to the voting capital stock of the Seller.


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                  (h) Subsidiaries. The Seller does not own, directly or
indirectly, any equity or other ownership interest in any subsidiary,
corporation, partnership, joint venture or other entity.

                  (i) Brokers' Fees. The Seller has no liability or obligation
to pay any commissions to any broker, finder, or agent with respect to the
transactions contemplated by this Agreement for which the Buyer could become
obligated.

                  (j) SEC Filings; SEC Financial Statements.

                           (i) The Seller has filed all forms, reports and
documents required to be filed with the SEC since December 31, 1994, and has
heretofore made available to Buyer, in the form filed with the SEC, its (A)
annual reports on Form 10-KSB for the fiscal years ended October 31, 1999 and
1998 (including all amendments prior to the date hereof), (B) all proxy
statements relating to the Seller's meetings of its stockholders (whether annual
or special) held since October 31, 1998 and (C) all other forms, reports,
registrations, schedules, statements and other documents required to be filed by
the Seller since October 31, 1998 with the SEC pursuant to the Exchange Act or
the Securities Act (as such documents referred to herein have been amended since
the time of their filing, collectively, the "SEC Reports"). As of their
respective dates, or, if amended, as of the date of the last such amendment, the
SEC Reports, including without limitation, any financial statements or schedules
included therein (the "SEC Financial Statements") (A) complied in all material
respects with the applicable requirements of the Exchange Act and the Securities
Act, as the case may be, and the applicable rules and regulations of the SEC
promulgated thereunder, and (B) did not contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements therein, in the light of the
circumstances under which they were made, not misleading.

                           (ii) The SEC Financial Statements have been prepared
from, and are in accordance with the books and records of the Seller, comply in
all material respects with applicable accounting requirements and with the
published rules and regulations of the SEC with respect thereto, have been
prepared in accordance with GAAP applied on a consistent basis throughout the
periods involved (except as may be indicated in the notes thereto) and fairly
presented the financial position of the Seller and its results of operation,
cash flows and changes in financial position as of and for the periods
indicated, except that the unaudited interim financial statements contained in
the SEC Reports were or are subject to normal and recurring year-end
adjustments.

                  (k) Events Subsequent to the Most Recent Fiscal Year End.
Except as disclosed in paragraph 5(k) of the Seller's Disclosure Schedule, since
October 31, 1999, the Seller has conducted its business only in the Ordinary
Course of Business and there has not been any material adverse change in the
business, financial condition, results of operations, or future prospects of the
Seller. Without limiting the generality of the foregoing, since October 31,
1999:

                           (i) there have not occurred any events or changes
(including the incurrence of any liabilities of any nature, whether or not
accrued, contingent or otherwise) having, individually or in the aggregate, a
material adverse effect upon the present or future financial condition or the
future results of operations of the Seller;


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                           (ii) the Seller has not sold, leased, transferred, or
assigned any of its assets, tangible or intangible, other than for a fair
consideration in the Ordinary Course of Business;

                           (iii) the Seller has not entered into any agreement,
contract, lease or license (or series of related agreements, contracts, leases,
or licenses) either involving more than $50,000 or outside the Ordinary Course
of Business;

                           (iv) the Seller has not delayed or postponed the
payment of accounts payable and other Liabilities outside the Ordinary Course of
Business;

                           (v) there has been no change made or authorized in
the certificate of incorporation or bylaws of the Seller;

                           (vi) except as set forth in Seller's Disclosure
Schedule, the Seller has not issued, sold, or otherwise disposed of any of its
capital stock, or granted any options, warrants or other rights to purchase or
obtain (including conversion, exchange or exercise) any of its capital stock ;

                           (vii) the Seller has not made any loan to, or entered
into any other transaction with, any of its directors, officers and employees
outside the Ordinary Course of Business;

                           (viii) the Seller has not made or pledged to make any
charitable or other capital contribution outside the Ordinary Course of
Business;

                           (ix) there has not been any other material adverse
occurrence, event, incident, action, failure to act or transaction outside the
Ordinary Course of Business involving the Seller; and

                           (x) the Seller has not committed to any of the
foregoing.

                  (l) Undisclosed Liabilities. The Seller has no Liability (and
there is no basis for any present or future action, suit, proceeding, hearing,
investigation, charge, complaint, claim, or demand against the Seller), except
for (i) material Liabilities set forth in the SEC Financial Statements
(including in any notes thereto) and (ii) material Liabilities which have arisen
after the most recent interim financial statements included in the SEC Financial
Statements in the Ordinary Course of Business (none of which results from,
arises out of, relates to, is in the nature of, or was caused by any breach of
contract, breach of warranty, tort, infringement or violation of law) .

                  (m) Legal Compliance. The Seller has materially complied with
all applicable laws (including rules, regulations, codes, plans, injunctions,
judgments, orders, decrees, rulings and charges thereunder) of federal, state ,
local and foreign governments (and all agencies thereof) and Seller has no
Knowledge of any action, suit, proceeding, hearing, investigation, charge,
complaint, claim, demand or notice having been filed or commenced against it

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alleging any failures to so comply, except where any such noncompliance, or
alleged noncompliance if proven, would not either individually or in the
aggregate have a material adverse affect upon the financial condition or results
of operations of Seller.

                  (n)      Taxes.

                           (i) (A) Subject to any extension which have been
obtained, Seller has timely filed with the appropriate Tax Authority all Tax
Returns required to be filed by or with respect to the Seller, and such Tax
Returns are true, correct and complete in all material respects; (B) all Taxes
due and payable by the Seller, with respect to the taxable years or other
taxable periods ending on or prior to the Closing Date have been or on or prior
to the Closing Date will be, paid or adequately disclosed and fully provided
for; (C) no Audits are pending or, to the Knowledge of the Seller, threatened
with regard to any Taxes or Tax Returns of the Seller and there are no
outstanding deficiencies or assessments asserted or, to the Knowledge of the
Seller, proposed; (D) no issue has been raised by any Taxing Authority in any
Audit of the Seller that if raised with respect to any other period not so
audited could reasonably be expected to result in a proposed deficiency of any
period not so audited that would have a material adverse effect upon the
financial condition or results of operations of the Seller; (E) there are no
outstanding agreements, consents or waivers extending the statutory period of
limitations applicable to the assessment of any Taxes or deficiencies against
the Seller, and the Seller is not a party to any agreement providing for the
allocation or sharing of Taxes; and (F) no powers of attorney with respect to
Taxes of the Seller have been executed that will be outstanding as of the
Closing Date.

                           (ii) The Seller has not filed a consent to the
application of Section 341(f) of the Code.

                           (iii) The Seller has not been a United States real
property holding company (as defined in Section 897(c)(2) of the Code) during
the applicable period specified in Section 897(c)(1)(ii) of the Code.

                           (iv) No indebtedness of the Seller is "corporate
acquisition indebtedness" within the meaning of Section 279(b) of the Code.

                           (v) The Seller has not entered into any agreements
that would result in the disallowance of any tax deductions pursuant to Section
280G of the Code.

                           (vi) There are no liens for Taxes upon any of the
assets of the Seller, except for Liens for Taxes not yet due and payable for
which adequate reserves have been established on the Seller's balance sheet at
October 31, 1999 included in the Seller's Annual Report on Form 10-KSB filed
with the SEC prior to the date hereof in accordance with GAAP.

                           (vii) The Seller has disclosed all material Tax
elections to Buyer.

                  (o) Real Property. Paragraph 5(o) of Seller's Disclosure
Schedule sets forth a complete list and description of all real property owned
by the Seller (the "Real Property"). The Seller has good and marketable title to
the Real Property. There are no existing or, to Seller's Knowledge, threatened
proceedings, claims, condemnation proceedings, lawsuits, administrative actions,
disputes or conditions affecting any Real Property that might curtail or


                                       9
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interfere in any material respect with the use of such property, nor is an
action of eminent domain pending or to the Knowledge of the Seller, threatened
for all or any portion of the Real Property. Except as disclosed in paragraph
5(o) of the Seller's Disclosure Schedule, the Seller is not a party to any
lease, assignment or similar arrangement under which the Seller is a lessor,
assignor or otherwise makes available for use by any third party any portion of
the Real Property. The Seller has obtained all appropriate material licenses,
permits, easements and rights of way, including proofs of dedication, required
to use and operate the Real Property in all material respects in the manner in
which the Real Property is currently being used and operated.

                  (p) Title and Condition of Properties. The Seller has good and
marketable title, free and clear of all liens, to its personal property and
assets shown on the most recent balance sheet of the SEC Financial Statements or
acquired thereafter, except for (i) assets which have been disposed of to
nonaffiliated third parties since the date of the most recent balance sheet of
the SEC Financial Statements in the Ordinary Course of Business, liens or
imperfections of title which are not, individually or in the aggregate, material
in character, amount or extent and which do not materially detract from the
value or materially interfere with the present or presently contemplated use of
the assets subject thereto or affected thereby, and (iii) liens for current
Taxes not yet due and payable.

                  (q) Intellectual Property.

                           (i) Paragraph 5(q) of the Seller's Disclosure
Schedule contains a true and complete list of all material (A) patents and
patent applications, (B) trademark registrations and applications, (C) service
mark registrations and applications, (D) Computer Software (as hereinafter
defined)(excluding Computer Software generally available for purchase by the
public), (E) copyright registrations and applications, (F) unregistered
trademarks, service marks, and copyrights, and (G) Internet domain names used or
held for use in connection with the business of the Seller, together with all
licenses related to the foregoing.

                           (ii) The term "Computer Software" shall mean (A) any
and all computer programs and applications consisting of sets of statements and
instructions to be used directly or indirectly in computer software or firmware
whether in source code or object code form, (B) databases and compilations,
including without limitation any and all data and collections of data, whether
machine readable or otherwise, (C) all versions of the foregoing including,
without limitation, all screen displays and designs thereof, and all component
modules of source code or object code or natural language code therefor, and
whether recorded on papers, magnetic media or other electronic or non-electronic
device, (D) all descriptions, flowcharts and other work product used to design,
plan, organize and develop any of the foregoing, (E) all documentation,
including without limitation all technical and user manuals and training
materials, relating to the foregoing, and all Internet domain names and content
contained on all world wide web sites of the Seller.

                           (iii) The Seller owns or has the valid right to use
all of the Intellectual Property used by it or held for use by it in connection
with its business. The Seller is the sole and exclusive owner of all patents,
patent applications, patent rights, copyrights, trademarks, trademark rights,
trade names, trade name rights, and service marks, and all goodwill of the
business associated therewith, trade secrets, registrations for and applications
for registration of trademarks, service marks and copyrights, technology and


                                       10
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know-how, Computer Software other than off-the-shelf applications and other
confidential or proprietary rights and information made or used in connection
with any of the foregoing, used or held for use anywhere in the world in
connection with its business as currently conducted (collectively, the
"Intellectual Property"), free and clear of all material Liens.

                           (iv) All grants, registrations and applications for
Intellectual Property that are used in and are material to the conduct of the
business of the Seller as currently conducted (A) are valid, subsisting, in
proper form and enforceable, and have been duly maintained, including the
submission of all necessary filings and fees in accordance with the legal and
administrative requirements of the appropriate jurisdictions and (B) have not
lapsed, expired or been abandoned, and no application or registration therefor
is the subject of any legal or governmental proceeding before any governmental,
registration or other authority in any jurisdiction, except to the extent where
the absence of such Intellectual Property would not have a material adverse
effect upon the financial condition or results of operations of the Seller.

                           (v) To the Knowledge of the Seller, there are no
conflicts with or infringements of any Intellectual Property by any third party.
The conduct of the respective businesses of the Seller as currently conducted
does not conflict with or infringe in any way on any proprietary right of any
third party. There is no claim, suit, action or proceeding pending or, to the
Knowledge of the Seller, threatened against the Seller (A) alleging any such
conflict or infringement with any third party's proprietary rights, or (B)
challenging the ownership, use, validity or enforceability of the Intellectual
Property.

                           (vi) The Seller is not, nor will it be as a result of
the execution and delivery of this Agreement or the performance of its
obligations under this Agreement, in breach of any material license, sublicense
or other agreement relating to the Intellectual Property, except where any such
breach(es) will not individually or in the aggregate have a material adverse
affect upon the financial condition or results of operations of Seller.

                           (vii) No former or present employees, officers or
directors of the Seller hold any right, title or interest directly or
indirectly, in whole or in part, in or to any Intellectual Property.

                  (r)      Contracts.

                           (i) The SEC Reports contain a list of all material
contracts to which the Seller is a party or by which the Seller is bound.

                           (ii) The Seller has filed with the SEC a correct and
complete copy of each of the written agreements referenced in Section 5(r)(i)
above.

                           (iii) With respect to each agreement referenced in
Section 5(r)(i) above, each agreement is: (A) legal, valid, binding, enforceable
and in full force and effect; (B) will continue to be legal, valid, binding,
enforceable, and in full force and effect on identical terms following the
consummation of the transactions contemplated hereby; (C) Seller has no
Knowledge that any other party to any such agreement is in material breach or
default, and Seller has no Knowledge that any event has occurred which with
notice or lapse of time would constitute a breach or default, or permit
termination, modification, or acceleration, under the agreement, and (D) Seller
has no Knowledge that any other party has repudiated any provision of the
agreement.


                                       11
<PAGE>

                  (s) Litigation. There are no claims, judgments, orders,
decrees, rulings, charges, actions, suits, proceedings, (including, without
limitation, arbitration proceedings), injunctions or alternative dispute
resolution proceedings, or investigations pending or, to the Knowledge of the
Seller, threatened against the Seller or any properties or rights of the Seller,
before any court or quasi-judicial or administrative agency of any federal,
state, local or foreign jurisdiction or before any arbitrator that, either
individually or in the aggregate would be reasonably likely to have a material
adverse effect upon the financial condition or the results of operations of the
Seller. As of the date hereof, the Seller is not subject to any material
outstanding order, judgment, injunction or decree.

                  (t) Employees. To the best Knowledge of the Seller, no
executive, key employee or group of employees has any plans to terminate
employment with the Seller. The Seller is not a party to any collective
bargaining agreement. The Seller has not experienced any strike, grievance,
claim of unfair labor practice or other collective bargaining disputes. The
Seller has not committed any unfair labor practice. To the best Knowledge of the
Seller, no organizational effort presently is being made or threatened by or on
behalf of any labor union with respect to employees of the Seller. The Seller
has complied in all material respects with all applicable laws relating to
employment, employment discrimination and employment practices.

                  (u) Employee Benefit Plans (see MAS Employee Stock Option
Plan).

                           (i) Paragraph 5(u) of the Seller's Disclosure
Schedule sets forth a list of all "Employee Welfare Benefit Plans" (as defined
in Section 3(l) of the Employee Retirement Income Security Act of 1974, as
amended ("ERISA"), "Employee Pension Benefit Plans" (as defined in Section 3(2)
of ERISA), employment agreements and all other bonus, stock option, stock
purchase, benefit, profit sharing, savings, retirement, disability, insurance,
incentive, deferred compensation and other similar fringe or employee benefit
plans, programs or arrangements for the benefit of, or relating to, any employee
of, or independent contractor or consultant to, the Seller (together, the
"Employee Plans"). With respect to each Employee Plan, the Seller has made
available to Buyer true and complete copies of (A) all plan documents, as in
effect on the date hereof, and will make available all other employee plans,
together with all amendments thereto which will become effective at a later
date, (B) the latest Internal Revenue Service determination letter, (C) the last
filed Form 5500, (D) summary plan description, if any, and all modifications
thereto communicated to employees, and (E) the most recent annual and periodic
accounting of related plan assets, if any. Neither the Seller, its directors,
officers, employees or agents has, with respect to any Employee Plan, engaged in
or been a party to any "prohibited transaction," as such term is defined in
Section 4975 of the Code or Section 406 of ERISA, which could result in the
imposition of either a material penalty assessed pursuant to Section 502(i) of
ERISA or a material tax imposed by Section 4975 of the Code, in each case
applicable to the Seller or any Employee Plan. All Employee Plans are in
compliance in all material respects with the currently applicable requirements
prescribed by all statutes, orders, or governmental rules or regulations
currently in effect with respect to such Employee Plans, including, but not
limited to, ERISA and the Code and, to the Knowledge of the Seller, there are no
pending or threatened claims, lawsuits or arbitrations (other than routine
claims for benefits), relating to any of the Employee Plans, which have been
asserted or instituted against the Seller, any Employee Plan or the assets of
any trust for any Employee Plan. Each Employee Plan intended to qualify under
Section 401(a) of the Code, and the trusts created thereunder intended to be
exempt from tax under the provisions of Section 501(a) of the Code has received
a favorable determination letter from the Internal Revenue Service to such


                                       12
<PAGE>

effect or is still within the "remedial amendment period." No Employee Plan is a
"Multiemployer Plan" (as defined in Section 3(37) of ERISA) or is subject to
Title IV of ERISA. The Seller has fully complied with the provisions of Section
4980B of the Code and Part 6 of Title I of ERISA. The requirements of COBRA have
been met with respect to each such Employee Plan which is an Employee Welfare
Benefit Plan. All contributions (including employer contributions and employee
salary reduction contributions) which are due have been paid to each such
Employee Plan which is an employee benefit pension plan and all contributions
for any period ending on or before the Closing Date which are not yet due have
been paid to each such employee benefit pension plan or accrued in accordance
with the past custom and practice of the Seller. All premiums or other payments
for all periods ending on or before the Closing Date have been paid with respect
to each such Employee Plan which is an Employee Welfare Benefit Plan.

                           (ii) All required reports and descriptions (including
Form 5500 Annual Reports, summary annual reports, PBGC-1s, and summary plan
descriptions) have been timely filed and distributed appropriately with respect
to each such Employee Plan.

                           (iii) The market value of assets under each such
Employee Plan which is an Employee Pension Benefit Plan equals or exceeds the
present value of all vested and nonvested Liabilities thereunder determined in
accordance with PBGC methods, factors and assumptions applicable to an Employee
Pension Benefit Plan terminating on the date for determination.

                  (v) Guaranties.  The Seller is not a guarantor or otherwise
liable for any Liability or obligation (including indebtedness) of any other
Person.

                  (w) Environmental Matters. Except for matters disclosed in
paragraph 5(w) of the Seller's Disclosure Schedule:

                           (i) The Seller is in compliance with all
Environmental Laws, and the Seller has not received written notice of any
outstanding allegations by any person or entity that the Seller is not or has
not been in compliance (unless such non-compliance has been cured) with any
Environmental Laws.

                           (ii) The Seller currently holds all material permits,
licenses, registrations and other governmental authorizations and financial
assurances required under any Environmental Laws for the Seller to operate its
business except for such permits, licenses, registrations and other governmental
authorization and financial assurances, the failure of the Seller to hold is not
reasonably expected to result in a material adverse effect upon the financial
condition or the results of operations of the Seller.

                           (iii) To the best of the Seller's Knowledge, there is
no asbestos or asbestos-containing materials in or on any real property,
buildings, structures or components thereof currently owned, leased or operated
by the Seller. To the best of the Seller's Knowledge, there are and have been no
underground or aboveground storage tanks (whether or not required to be
registered under any applicable law), dumps, landfills, lagoons, surface


                                       13
<PAGE>

impoundments, sumps, injection wells or other disposal or storage sites or
locations in or on any property currently owned, leased or operated by the
Seller for any matter that is reasonably expected to result in a material
adverse effect upon the financial condition or the results of operations of the
Seller.

                           (iv) The Seller has not received (A) any
communication from any person stating or alleging that it is or may be a
potentially responsible party under any Environmental Law (including, without
limitation, the Comprehensive Environmental Response, Compensation and Liability
Act of 1980, as amended, and any state analog thereto) with respect to any
actual or alleged environmental contamination or (B) any request for information
under any Environmental Law from any governmental agency or authority or any
other person or entity with respect to any active or alleged environmental
contamination or violation.

                           (v) The Seller is not a party to any pending judicial
or administrative proceedings alleging that it is a potentially responsible
party under the Comprehensive Environmental Response, Compensation, and
Liability Act of 1980, as amended, and any state analog thereto) or otherwise
liable or responsible with respect to any actual or alleged environmental
contamination.

                           (vi) No governmental agency or authority, or any
other person or entity is conducting and has not conducted (nor is proposing or
threatening to conduct) any environmental remediation or investigation of the
Seller.

                  (x) Health and Safety. The Seller has not received any written
or oral notice, report or other information regarding any actual or alleged
violation of Health and Safety Requirements, or any Liabilities, including any
investigatory, remedial or corrective obligations, relating to Seller or its
facilities arising under Health and Safety Requirements.


                  (y) Insurance Policies. All material policies of fire,
liability, workmen's compensation and other similar forms of insurance owned or
held by the Seller are in full force and effect, and no notice of cancellation
or termination has been received with respect to any such policy. Such policies
are valid, outstanding and enforceable policies, and will not in any way be
affected by, or terminate or lapse by reason of, the transactions contemplated
by this Agreement. Such policies, provide, to the Knowledge of the Seller,
insurance coverage that is adequate for the assets and operations of the Seller.
Since October 31, 1997, the Seller has been covered by insurance in scope and
amount customary and reasonable for the business in which it has engaged during
such period.

         6. Representations and Warranties of the Buyer. The Buyer represents
and warrants to the Seller that the statements contained in this Section 6 are
correct and complete as of the date of the Closing Date. The Buyer represents
and warrants to the Seller as follows:

                  (a) No Registration of the Shares. The Buyer understands that:
(i) the Shares are being sold to the Buyer under one or more exemptions from the
registration provisions of the Securities Act; (ii) the Buyer is purchasing such
Shares without being furnished any offering literature or prospectus other than
the information set forth herein and publicly disseminated information regarding
the Seller and its Common Stock; and (iii) the sale of the Shares has not been


                                       14
<PAGE>

examined by the SEC or by any agency charged with the administration of the
securities laws of any state or other jurisdiction. The Buyer represents and
warrants that it is an accredited investor as defined in Rule 501 under
Regulation D of the Rules of the United States Securities and Exchange
Commission under the Securities Act and that it has such Knowledge and
experience in financial and business matters that it is capable of evaluating
the merits and risks of an investment in the Shares and of making an informed
investment decision with respect thereto. The Buyer understands that the Seller
is relying on the truth and accuracy of the representations, declarations and
warranties made herein by the Buyer in selling the Shares hereunder without
having first registered such Shares under the Securities Act or under the
securities laws of any state or other jurisdiction.

                  (b) Investment Intent. The Buyer confirms that: (i) it
understands that there are substantial restrictions on the transferability of
the Shares and, accordingly, it may not be possible for it to liquidate its
investment in the Shares in case of emergency; and (ii) it is able to bear the
economic risk of this investment in the Shares, to hold the Shares for an
indefinite period of time, and currently to afford a complete loss of this
investment. The Shares being acquired by the Buyer hereunder are being acquired
in good faith solely for its own account, for investment purposes only, and are
not being purchased with a view to or for the resale, distribution, subdivision
or fractionalization thereof. The Buyer does not have any contract, undertaking,
understanding, agreement or arrangement, formal or informal, with any person to
sell, transfer or pledge to any person the Shares being acquired hereunder, or
any part thereof, and has no current plan to enter into any such contract,
undertaking, agreement or arrangement. The Buyer understands that the legal
consequences of the foregoing representations and warranties are that it must
bear the economic risk of this investment in the Shares for an indefinite period
of time because the Shares have not been registered under the Securities Act.

                  (c) Decision to Invest. The Buyer confirms that, in making its
decision to invest in the Shares, it has relied solely upon independent
investigations made by it or its representatives and advisors, and that it and
such representatives and advisors have been given the opportunity to ask
questions of, and to receive answers from, management of the Seller with respect
to the Seller and the Seller's Common Stock.

                  (d) Organization of the Buyer. The Buyer is a corporation duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its incorporation.

                  (e) Authority. The Buyer has the corporate power to execute,
deliver and carry out the terms and provisions of this Agreement and has taken
all necessary corporate action to authorize the execution, delivery and
performance of this Agreement by the Buyer. This Agreement constitutes the valid
and legally binding obligation of the Buyer, enforceable in accordance with its
terms and conditions.

                  (f) No Consent Required. No authorization, consent or approval
of, or exemption by, any governmental or public body or authority is required to
authorize, or is required in connection with, the execution, delivery and
performance of any of this Agreement, or the taking of any action contemplated
hereby, by the Buyer, except those that have been obtained or are available.

                  (g) No Violation. Neither the execution and delivery of this
Agreement, nor compliance with any of the terms and provisions hereof, nor the


                                       15
<PAGE>

consummation of any of the transactions herein contemplated will not violate any
provision of any of the organizational documents of the Buyer, including but not
limited to its charter and bylaws.

                  (h) Brokers' Fees. The Buyer has no liability or obligation to
pay any commissions to any broker, finder, or agent with respect to the
transactions contemplated by this Agreement for which the Seller could become
obligated.

         7.       Securities Law Matters and Restrictions on the Shares.

                  (a)      Permitted Transfers.

                           (i) The Buyer understands and agrees that the Shares
being purchased hereunder may be transferred by it only pursuant to (A) a public
offering thereof registered under the Securities Act, (B) Rule 144 of the SEC
(or any similar rule in force at the time of such transfer) if such rule is
available, and (C) any other legally available means of transfer.

                           (ii) In connection with the transfer of any Shares,
the Buyer shall deliver written notice to the Seller describing in reasonable
detail the transfer or proposed transfer, together with an opinion of counsel
that is knowledgeable in securities law matters and reasonably acceptable to the
Seller, to the effect that such transfer may be effected without registration
under the Securities Act and under applicable state securities laws.
                  (b) Restrictive Legend. Each certificate for the Shares, and
any shares of capital stock received in respect thereof, whether by reason of a
stock split or share reclassification thereof, a stock dividend thereon or
otherwise, shall be stamped or otherwise imprinted with a legend in
substantially the following form:

                  THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE BEEN
                  ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE
                  SECURITIES ACT OF 1933 OR THE SECURITIES LAWS OF ANY STATE.
                  THESE SECURITIES MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE
                  OF SUCH REGISTRATION OR AN EXEMPTION THEREFROM UNDER SUCH ACT
                  AND APPLICABLE STATE SECURITIES LAWS.

                  (c) Current Public Information. The Seller shall use its best
efforts to file all reports required to be filed by it under the Exchange Act
and the rules and regulations thereunder and shall take such further action as
any holder of any Shares may reasonably request, all to the extent required to
enable any such holder to sell Shares pursuant to Rule 144 under the Securities
Act (as such rule may be amended from time to time) or any similar rule or
regulation then in force. Upon written request, the Seller shall deliver to any
holder of any Shares a written statement as to whether it has complied with such
requirements.

                  (d) Compliance with Securities Laws. The Buyer acknowledges
that it is required to comply with the provisions of the Exchange Act and other
applicable rules and regulations relating to its ownership of the Seller's
Common Stock. The Buyer agrees to comply in all respects with the provisions of
the Exchange Act and other applicable rules and regulations, to file all reports


                                       16
<PAGE>

required to be filed by it thereunder and to supply the Seller with all
information requested by it from time to time in order to permit the Seller to
comply with the provisions of the Exchange Act and other applicable laws, rules
and regulations.

         8.       Closing Covenants.  Each of the Parties agree as follows.

                  (a) General. Each of the Parties will use its reasonable best
efforts to take all action and to do all things necessary, proper or advisable
in order to consummate and make effective the transactions contemplated by this
Agreement.

                  (b) Use of Proceeds. Seller agrees to use the proceeds from
the sale of the Shares in accordance with Section 2(c) above.

                  (c) License Agreement. The Seller and the Buyer's wholly-owned
subsidiary, eRT, shall enter into the Licensing Agreement.

                  (d) Services Agreement. The Seller and the Buyer's wholly-
owned subsidiary, eRT, shall enter into the Services Agreement.

                  (e) Notices and Consents. The Seller will give any notice to
third parties, and will use its reasonable best efforts to obtain any third
party consents, if any, that the Buyer may reasonably request in connection with
the matters in Section 5(f). Each of the Parties will give any notices to, make
any filings with, and use its reasonable best efforts to obtain any required
authorizations, consents and approvals of governments and governmental agencies
in connection with the transactions contemplated herein.

                  (f) Right of First Refusal . The Seller will not engage in any
practice, or take any action or enter into any transaction in violation of
Section 3 of this Agreement.

                  (g) Preservation of Business. The Seller will keep its
business and properties substantially in tact, including its present operations,
physical facilities, working conditions and relationships with lessors,
licensors, suppliers, customers and employees.

                  (h) Full Access. The Seller will permit the Buyer, or its
representatives, to have the full access accorded to shareholders of the Buyer
and as authorized with respect to eRT under the License Agreement and the
Services Agreement at all reasonable times, and in a manner so as not to
interfere with the normal business operations of the Seller to all premises,
properties, books, and records (including Tax records), contracts and documents
of or pertaining to the Seller. No disclosure by the Seller hereunder shall be
deemed to amend or supplement the Seller's Disclosure Schedule or to prevent or
cure any misrepresentation, breach of warranty or breach of agreement.

                  (i) Notice of Developments. The Seller will give prompt
written notice to the Buyer of any material adverse development causing a breach
of any of the representations and warranties in Section 5 above. The Buyer will
give prompt written notice to the Seller of any material adverse development
causing a breach of any of the representations and warranties in Section 6
above.

         9.       Remedies for Breaches of this Agreement.


                                       17
<PAGE>

                  (a) Survival of Representations and Warranties. All of the
representations, warranties, covenants, and obligations in this Agreement, the
Seller's Disclosure Schedule, any certificates and documents delivered pursuant
to this Agreement will survive for a period of one (1) year Closing.

                  (b) Indemnification Provisions for the Benefit of the Buyer.
In the event the Seller breaches (or in the event that any third party alleges
facts that, if true, would mean the Seller has breached) any of its
representations and warranties, and covenants contained herein, provided that
the Buyer makes a written claim for indemnification against the Seller pursuant
to the notification requirements of Section 10(g) below, then the Seller agrees
to indemnify the Buyer from and against the entirety of any Adverse Consequences
the Buyer may suffer through and after the date of the claim for indemnification
(including any Adverse Consequences the Buyer may suffer after the end of any
applicable survival period) resulting from, arising out of, relating to, in the
nature of, or caused by the breach or alleged breach.

                  (c) Matters Involving Third Parties.

                           (i) If any third party shall notify any Party (the
"Indemnified Party") with respect to any matter (a "Third Party Claim") which
may give rise to a claim for indemnification against the other Party (the
"Indemnifying Party") under this Section 10, then the Indemnified Party shall
promptly notify the Indemnifying Party thereof in writing; provided, however,
that no delay on the part of the Indemnified Party in notifying any Indemnifying
Party shall relieve the Indemnifying Party from any obligation hereunder unless
(and then solely to the extent) the Indemnifying Party thereby is prejudiced.

                           (ii) Any Indemnifying Party will have the right to
defend the Indemnified Party against the Third Party Claim with counsel of the
Indemnifying Party's choice reasonably satisfactory to the Indemnified Party so
long as (A) the Indemnifying Party notifies the Indemnified Party in writing
within 15 days after the Indemnified Party has given notice of the Third Party
Claim that the Indemnifying Party will indemnify the Indemnified Party from and
against the entirety of any Adverse Consequences the Indemnified Party may
suffer resulting from, arising out of, relating to, in the nature of, or caused
by the Third Party Claim, (B) the Indemnifying Party provides the Indemnified
Party with evidence reasonably acceptable to the Indemnified Party that the
Indemnifying Party will have the financial resources to defend against the Third
Party Claim and fulfill its indemnification obligations hereunder, (C)
settlement of, or an adverse judgment with respect to, the Third Party Claim is
not, in the good faith judgment of the Indemnified Party, likely to establish a
precedential custom or practice materially adverse to the continuing business
interests of the Indemnified Party, and (D) the Indemnifying Party conducts the
defense of the Third Party Claim actively and diligently.

                           (iii) So long as the Indemnifying Party is conducting
the defense of the Third Party Claim in accordance with Section 9(c)(ii) above,
(A) the Indemnified Party may retain separate co-counsel at its sole cost and
expense and participate in the defense of the Third Party Claim, (B) the
Indemnified Party will not consent to the entry of any judgment or enter into
any settlement with respect to the Third Party Claim without the prior written
consent of the Indemnifying Party, not to be withheld unreasonably, and (C) the
Indemnifying Party will not consent to the entry of any judgment or enter into


                                       18
<PAGE>

any settlement with respect to the Third Party Claim without the prior written
consent of the Indemnified party, not to be withheld unreasonably.

                           (iv) In the event any of the conditions in Section
9(c)(ii) are or become unsatisfied, (A) the Indemnified Party may defend
against, and consent to the entry of any judgment or enter into any settlement
with respect to, the Third Party Claim in any manner it reasonably may deem
appropriate (and the Indemnified Party need not consult with, or obtain any
consent from the Indemnifying Party in connection therewith), (B) the
Indemnifying Party will reimburse the Indemnified Party promptly and
periodically for the costs of defending against the Third Party Claim (including
reasonable attorneys' fees and expenses), and (C) the Indemnifying Party will
remain responsible for any Adverse Consequences the Indemnified Party may suffer
resulting from, arising out of, relating to, in the nature of, or caused by the
Third Party Claim to the fullest extent provided in this Section 9.

         (d) Other Indemnification Provisions. The foregoing indemnification
provisions are in addition to, and not in derogation of, any statutory,
equitable, or common law remedy (including without limitation any such remedy
arising under Environmental Laws and Health and Safety Requirements) any Party
may have with respect to the transactions contemplated by this Agreement.

         10.      Miscellaneous.

                  (a) Press Releases. No party shall issue any press release or
make any public announcement relating to the subject matter of this Agreement
prior to Closing without the prior written approval of the other Party,
provided, however, that any Party may make a public disclosure it believes in
good faith is required by applicable law or any listing or trading agreement
concerning its publicly-traded securities (in which case, the disclosing Party
will use its reasonable best efforts to advise the other Party prior to making
the disclosure).

                  (b) No Third-Party Beneficiaries. This Agreement shall not
confer any rights or remedies upon any Person other than the Parties and their
respective successors and permitted assigns.

                  (c) Choice of Law. This Agreement shall be construed and
enforced in accordance with and pursuant to the laws of the State of Delaware
without giving effect to any choice or conflict of law provision or rule
(whether of the State of Delaware or any other jurisdiction) that would cause
the application of the laws of any jurisdiction other than the State of
Delaware.

                  (d) Binding Effect. This Agreement shall be binding upon and
inure to the benefit of the Parties hereto and their respective heirs,
successors, personal representatives and assigns.

                  (e) Entire Agreement. This Agreement, including the documents
referred to herein, constitutes the entire agreement between the Parties and
supersedes any prior understandings, agreements or representations by or between
the Parties, written or oral, to the extent they relate in any way to the
subject matter hereof.


                                       19
<PAGE>

                  (f) Counterparts. This Agreement may be executed in multiple
counterparts, each of which shall be deemed an original Agreement, and all of
which shall constitute one Agreement to be effective as of the date of this
Agreement.

                  (g) Notices. All notices, requests or other communications
hereunder shall be in writing and shall be deemed to have been duly given if
delivered in person or by courier; sent by overnight courier, charges prepaid;
or telegraphed, telexed or mailed by certified or registered mail, postage
prepaid, to the address of the respective Party set forth below:

         If to the Buyer:

                  Premier Research Worldwide, Ltd.
                  30 South 17th Street
                  Philadelphia, PA 19103-4001
                  Attention:  Joel Morganrath, MD, Chairman and
                              Chief Executive Officer

                  with a copy to:
                  Duane, Morris & Heckscher LLP
                  4200 One Liberty Place
                  Philadelphia, PA  19103-7396
                  Attention:  Sheldon M. Bonovitz, Esquire

         If to the Seller:

                  Medical Advisory Systems Inc.
                  8050 Southern Maryland Blvd.
                  Owings, MD  20736
                  Attention:

                  (h) Headings. The section headings contained in this Agreement
are inserted for convenience only and shall not affect in any way the meaning or
interpretation of this Agreement.

                  (i) Amendments. No amendment of any provision of this
Agreement shall be valid unless the same shall be in writing and signed by the
Buyer and the Seller.

                  (j) Severability. Any term or provision of this Agreement that
is invalid or unenforceable in any situation in any jurisdiction shall not
effect the validity or enforceability of the remaining terms and provisions
hereof or the validity or enforceability of the offending term or provision in
any other situation or in any other jurisdiction.



                                       20
<PAGE>

         IN WITNESS WHEREOF, the undersigned have hereunto executed this
Agreement the day and year first above written.

                                         MEDICAL ADVISORY SYSTEMS, INC.

                                         By: /s/ Ronald W. Pickett
                                             -----------------------------------
                                             Title:  /s/ President
                                                     ---------------------------

                                         PREMIER RESEARCH WORLDWIDE, LTD.

                                         By: /s/ Joel Morganroth, M.D.
                                             -----------------------------------
                                             Title:  /s/ Chairman and CEO
                                                     ---------------------------

                                       21