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                                                                 Exhibit 10.2.53


                     SCHEDULE IDENTIFYING OMITTED DOCUMENTS

         The only particulars in which the attached agreement differs from the
omitted agreements is the name of the employee who is a party to the agreements
and the number of options granted subject to the agreements.


               Name                     Number of Options Granted
               ----                     -------------------------
          Brent L. Larson                         60,000
            Carl Bosch                            45,000

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                              NEOPROBE CORPORATION
                                    SUITE 300
                              425 METRO PLACE NORTH
                             DUBLIN, OHIO 43017-1367


                                 January 4, 2000

                                  David C. Bupp
                               5747 Rushwood Drive
                                Dublin, OH 43017


         Congratulations. You have been granted a Stock Option under Neoprobe's
1996 Stock Incentive Plan (the "Plan") on the following terms:

         1. NUMBER OF SHARES. The number of Shares of Common Stock of Neoprobe
         Corporation that you may purchase under this Option is: 180,000.

         2. EXERCISE PRICE. The exercise price to purchase Shares under this
         Option is: $0.50 per Share.

         3. VESTING. One third (1/3) of the Shares originally subject to this
         Option will vest and become exercisable on each anniversary of the date
         of grant (January 4, 2000) if you have been an Employee of the Company
         continuously from the date of this Agreement shown above through the
         date when such portion of the Option vests.

         4. LAPSE. This Option will lapse and cease to be exercisable upon the
         earliest of:

                  (i)      the expiration of 10 years from the date of this
                           Agreement shown above,

                  (ii)     9 months after you cease to be an Employee because of
                           your death or disability,

                  (iii)    90 days after your employment with Neoprobe or any
                           Subsidiary is terminated by Neoprobe or such
                           Subsidiary without cause or by your resignation or
                           retirement.

                  (iv)     immediately upon termination of your employment with
                           Neoprobe or any Subsidiary by Neoprobe for cause.

         5. TAXATION. This Option is a Nonqualified Option. You will have
         taxable income upon the exercise of this Option. At that time, you must
         pay to Neoprobe an amount equal to the required federal, state and
         local tax withholding less any withholding otherwise made from your
         salary or bonus. You must satisfy any relevant withholding requirements
         before Neoprobe issues Shares to you.

         6. EXERCISE. This Option may be exercised by the delivery of this
         Agreement with the notice of exercise attached hereto properly
         completed and signed by you to the Treasurer of the Company, together
         with the aggregate Exercise Price for the number of Shares as to which
         the Option is being exercised, after the Option has become exercisable
         and before it has ceased to be exercisable. The Exercise Price must be
         paid in cash by (a) delivery of a certified or cashier's check payable
         to the order of Neoprobe in such amount, (b) wire transfer of
         immediately available funds to a bank account designated by Neoprobe,
         or (c) reduction of a debt of Neoprobe to you. This Option may be
         exercised as to less than all of the Shares purchasable hereunder, but
         not for a fractional share, nor may it be exercised as to less than one
         hundred (100) Shares unless it is exercised as to all of the Shares
         then available hereunder. If this Option is exercised as to less than
         all of the Shares purchasable hereunder, a new duly executed Option
         Agreement reflecting the decreased number of Shares exercisable under
         such Option, but otherwise of the same tenor, will be returned to you.


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         7. NO TRANSFER. This Option may not be sold, pledged nor otherwise
         transferred other than by will or the laws of descent and distribution;
         and it may only be exercised during your lifetime by you. This
         Agreement is neither a negotiable instrument nor a security (as such
         term is defined in Article 8 of the Uniform Commercial Code).

         8. NOT AN EMPLOYMENT AGREEMENT. This Agreement is not an employment
         agreement and nothing contained herein gives you any right to continue
         to be employed by or provide services to Neoprobe or affects the right
         of Neoprobe to terminate your employment or other relationship with
         you.

         9. PLAN CONTROLS. This Agreement is an Option Agreement (as such term
         is defined in the Plan) under Article 5 of the Plan. The terms of this
         Agreement are subject to, and controlled by, the terms of the Plan, as
         it is now in effect or may be amended from time to time hereafter,
         which are incorporated herein as if they were set forth in full. Any
         words or phrases defined in the Plan have the same meanings in this
         Agreement. Neoprobe will provide you with a copy of the Plan promptly
         upon your written or oral request made to its Vice President, Finance
         and CFO.

         10. MISCELLANEOUS. This Agreement sets forth the entire agreement of
         the parties with respect to the subject matter hereof and it supersedes
         and discharges all prior agreements (written or oral) and negotiations
         and all contemporaneous oral agreements concerning such subject matter.
         This Agreement may not be amended or terminated except by a writing
         signed by the party against whom any such amendment or termination is
         sought. If any one or more provisions of this Agreement shall be found
         to be illegal or unenforceable in any respect, the validity and
         enforceability of the remaining provisions hereof shall not in any way
         be affected or impaired thereby. This Agreement shall be governed by
         the laws of the State of Delaware.


Please acknowledge your acceptance of this Agreement by signing the enclosed
copy in the space provided below and returning it promptly to Neoprobe.


                                     NEOPROBE CORPORATION



                                     By:          /s/ Brent L. Larson
                                          --------------------------------------
                                                    Brent L. Larson
                                               Vice President, Finance &
                                                Chief Financial Officer


Accepted and Agreed to as of
the date first set forth above:



/s/ David C. Bupp
-------------------
Employee Signature



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                              OPTION EXERCISE FORM


The undersigned hereby exercises the right to purchase ________________________
shares of Common Stock of Neoprobe Corporation pursuant to the Option Agreement
dated January 4, 2000 under the Neoprobe Corporation 1996 Stock Incentive Plan.


Date: __________________________________        ________________________________
                                                       Employee Signature


________________________________________
Officer Approval


Sign and complete this Option Exercise Form and deliver it to:

                              Neoprobe Corporation
                                 Attn: Treasurer
                              425 Metro Place North
                                    Suite 300
                             Dublin, Ohio 43017-1367

together with the option price in cash by (a) delivery of a certified or
cashier's check payable to the order of Neoprobe in such amount, (b) wire
transfer of immediately available funds to a bank account designated by Neoprobe
or (c) reduction of a debt of Neoprobe to you.