57358 Federal Register / Vol. 73, No. 192 / Thursday, October 2, 2008 / Notices 

the office of the Board of Governors. 

Interested persons may express their 

views in writing to the Reserve Bank 

indicated for that notice or to the offices 

of the Board of Governors. Comments 

must be received not later than October 

17, 2008. 

A. Federal Reserve Bank of Chicago 

(Burl Thornton, Assistant Vice 

President) 230 South LaSalle Street, 

Chicago, Illinois 60690–1414: 

1. Peter T. Rogers, Appleton, 

Wisconsin, to retain voting shares of 

M.S.B. Bancorporation, Inc., and 

thereby indirectly retain voting shares of 

Premier Community Bank, Marion, 

Wisconsin. 

Board of Governors of the Federal Reserve 

System, September 29, 2008. 

Robert deV. Frierson, 

Deputy Secretary of the Board. 

[FR Doc. E8–23218 Filed 10–1–08; 8:45 am] 

BILLING CODE 6210–01–S 

FEDERAL RESERVE SYSTEM 

Consumer Advisory Council; Notice of 

Meeting of the Consumer Advisory 

Council 

The Consumer Advisory Council will 

meet on Thursday, October 23, 2008. 

The meeting, which will be open to 

public observation, will take place at the 

Federal Reserve Board’s offices in 

Washington, DC, in Dining Room E on 

the Terrace Level of the Martin 

Building. Anyone planning to attend the 

meeting should, for security purposes, 

register no later than Tuesday, October 

21, by completing the form found on 

line at: https://www.federalreserve.gov/ 

secure/forms/cacregistration.cfm. 

Additionally, attendees must present 

photo identification to enter the 

building. 

The meeting will begin at 9 a.m. and 

is expected to conclude at 1 p.m. The 

Martin Building is located on C Street, 

NW., between 20th and 21st Streets. 

The Council’s function is to advise 

the Board on the exercise of the Board’s 

responsibilities under various consumer 

financial services laws and on other 

matters on which the Board seeks its 

advice. Time permitting, the Council 

will discuss the following topics: 

• Housing and Economic Reco very 

Act of 2008: Members will discuss 

various initiatives included in the 

legislation, such as the new Federal 

Housing Administration ‘‘HOPE for 

Homeowners’’ refinancing program and 

the provision of $4 billion in block grant 

funds for the redevelopment of 

abandoned and foreclosed homes 

• Proposed rules regarding credit 

cards and overdraft services: Members 

will discuss issues raised in the public 

comments received on the Board’s 

proposed rules prohibiting unfair or 

deceptive acts or practices in 

connection with credit card accounts 

and overdraft services for deposit 

accounts. 

• Home Mortgage Disclosure Act 

(HMDA): Members will discuss key 

findings from the 2007 HMDA data. 

Reports by committees and other 

matters initiated by Council members 

also may be discussed. 

Persons wishing to submit views to 

the Council on any of the above topics 

may do so by sending written 

statements to Jennifer Kerslake, 

Secretary of the Consumer Advisory 

Council, Division of Consumer and 

Community Affairs, Board of Governors 

of the Federal Reserve System, 

Washington, DC 20551. Information 

about this meeting may be obtained 

from Ms. Kerslake, 202–452–6470. 

Board of Governors of the Federal Reserve 

System, September 29, 2008. 

Jennifer J. Johnson, 

Secretary of the Board. 

[FR Doc. E8–23241 Filed 10–1–08; 8:45 am] 

BILLING CODE 6210–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Toxicology Program (NTP); 

Office of Liaison, Policy and Review; 

Meeting of the NTP Board of Scientific 

Counselors 

AGENCY: National Institute of 

Environmental Health Sciences 

(NIEHS), National Institutes of Health. 

ACTION: Meeting announcement and 

request for comments. 

SUMMARY: Pursuant to Public Law 92– 

463, notice is hereby given of a meeting 

of the NTP Board of Scientific 

Counselors (NTP BSC). The NTP BSC is 

a federally chartered, external advisory 

group composed of scientists from the 

public and private sectors that provides 

primary scientific oversight to the NTP 

Director and evaluates the scientific 

merit of the NTP’s intramural and 

collaborative programs. 

DATES: The NTP BSC meeting will be 

held on November 20–21, 2008. The 

deadline for submission of written 

comments is November 6, 2008, and for 

pre-registration to attend the meeting, 

including registering to present oral 

comments, is November 13, 2008. 

Persons needing interpreting services in 

order to attend should contact 301–402– 

8180 (voice) or 301–435–1908 (TTY). 

For other accommodations while on the 

NIEHS campus, contact 919–541–2475 

or e-mail niehsoeeo@niehs.nih.gov. 

Requests should be made at least 7 days 

in advance of the event. 

ADDRESSES: The NTP BSC meeting will 

be held in the Rodbell Auditorium, Rall 

Building at the NIEHS, 111 T.W. 

Alexander Drive, Research Triangle 

Park, NC 27709. Public comments on all 

agenda topics and any other 

correspondence should be submitted to 

Dr. Barbara Shane, Executive Secretary 

for the NTP BSC, NTP Office of Liaison, 

Policy and Review, NIEHS, P.O. Box 

12233, MD A3–01, Research Triangle 

Park, NC 27709; telephone: 919–541– 

4253; fax: 919–541–0295; or e-mail: 

shane@niehs.nih.gov. Courier address: 

NIEHS, 111 T.W. Alexander Drive, 

Room A322, Research Triangle Park, NC 

27709. 

FOR FURTHER INFORMATION CONTACT: Dr. 

Barbara Shane (telephone: 919–541– 

4253 or e-mail: shane@niehs.nih.gov). 

SUPPLEMENTARY INFORMATION: 

Preliminary Agenda Topics and 

Availability of Meeting Materials 

November 20–21, 2008 

• Update of NTP activities 

• NTP testing program: nominations 

and proposed research projects on 

bisphenol AF, dimethylamine borane, 

ethylene glycol 2-ethylhexyl ether, 

hydroxyurea, L-betamethylaminoalanine, and triclosan 

• BSC working group report on 

criteria for evaluating outcomes in 

immunotoxicology studies 

• BSC working group report on 

criteria for evaluating outcomes in 

reproductive toxicology studies 

• BSC working group report on 

criteria for evaluating outcomes in 

developmental toxicology studies 

• Toxicology of DNA-based therapies 

• Concept review: production of mold 

materials 

• Sources of variability in NTP 

toxicogenomic studies 

• Update on the High Throughput 

Screening Initiative 

The preliminary agenda, roster of NTP 

BSC members and ad hoc reviewers, 

draft NTP research concepts, public 

comments, and any additional 

information, when available, will be 

posted on the NTP BSC meeting Web 

site (http://ntp.niehs.nih.gov/go/165) or 

may be requested in hardcopy from the 

Executive Secretary for the NTP BSC 

(see ADDRESSES above). Updates to the 

agenda will also be posted to this site. 

Following the meeting, summary 

minutes will be prepared and made 

available on the NTP meeting Web site. 

mstockstill on PROD1PC66 with NOTICES

Federal Register / Vol. 73, No. 192 / Thursday, October 2, 2008 / Notices 57359 

NTP Testing Program: Nominations and 

Proposed Research Projects 

The NTP actively seeks to identify 

and select for study chemicals and other 

substances for which sufficient 

information is not available to 

adequately evaluate potential human 

health hazards. The NTP accomplishes 

this goal through a formal open 

nomination and selection process. 

Substances considered appropriate for 

study generally fall into two broad, yet 

overlapping categories: (1) Substances 

judged to have high concern as possible 

public health hazards based on the 

extent of human exposure and/or 

suspicion of toxicity and (2) substances 

for which toxicological data gaps exist 

and additional studies would aid in 

assessing potential human health risks, 

e.g., by facilitating cross-species 

extrapolation or evaluating doseresponse relationships. Nominations are 

subject to a multi-step, formal process of 

review before selections for testing are 

made and toxicological studies are 

designed and implemented. The 

nomination review and selection 

process is accomplished through the 

participation of representatives from the 

NIEHS, other federal agencies 

represented on the Interagency 

Committee for Chemical Evaluation and 

Coordination (ICCEC), the NTP BSC, the 

NTP Executive Committee—the NTP 

federal interagency policy body, and the 

public. The nomination review and 

selection process is described in further 

detail on the NTP Web site (http:// 

ntp.niehs.nih.gov/, select ‘‘Nominations 

to the Testing Program’’). 

Table 1 lists new nominations to be 

reviewed at the NTP BSC meeting. 

Background documents for each 

nomination are available on the NTP 

Web site at http://ntp.niehs.nih.gov/go/ 

nom. The NTP invites interested parties 

to submit written comments, provide 

supplementary information, or present 

oral comments at the NTP BSC meeting 

on the nominated substances and 

preliminary study recommendations 

(see ‘‘Request for Comments’’ below). 

The NTP welcomes toxicology study 

information from completed, ongoing, 

or anticipated studies, as well as 

information on current U.S. production 

levels, use or consumption patterns, 

human exposure, environmental 

occurrence, or public health concerns 

for any of the nominated substances. 

The NTP is interested in identifying 

appropriate animal and non-animal 

experimental models for mechanisticbased research, including genetically 

modified rodents and high-throughput 

in vitro test methods, and as such, 

solicits comments regarding the use of 

specific in vivo and in vitro 

experimental approaches to address 

questions relevant to the nominated 

substances and issues under 

consideration. Although the deadline 

for submission of written comments to 

be considered at the NTP BSC meeting 

is November 6, 2008 (see ‘‘Request for 

Comments’’ below), the NTP welcomes 

comments or additional information on 

these study nominations at any time. 

TABLE 1—TESTING RECOMMENDATIONS FOR SUBSTANCES NOMINATED TO THE NTP FOR TOXICOLOGICAL STUDIES

Substance [CAS No.] Nominated by 1 Nomination rationale Preliminary study 

recommendations 2

Bisphenol AF [1478–61–1] ............ NIEHS ........................................... Moderate production and use in 

polymer synthesis; short-term 

studies suggest potential for endocrine disruption and adverse 

reproductive effects; lack of 

adequate toxicity data.

—Comprehensive toxicological 

characterization. 

Dimethylamine borane [74–94–2] .. National Institute for Occupational 

Safety and Health.

Possible contact sensitizer and 

systemic toxicant but insufficient evidence as determined 

by the NIOSH Dermal Subject 

Matter Expert Workgroup.

—Dermal absorption studies. 

—Skin sensitization studies. 

—Subchronic dermal toxicity studies with neurotoxicity and behavioral assessments. 

Ethylene glycol 2-ethylhexyl ether 

[1559–35–9].

NIEHS ........................................... High production volume; potential 

worker exposures; suspicion of 

toxicity based on chemical 

structure; lack of adequate toxicity data.

—Reproductive and developmental toxicity studies. 

Hydroxyurea [127–07–1] ............... NIEHS and Private Individual ....... Long-term safety concern when 

used as therapy for sickle cell 

anemia; NTP Center for the 

Evaluation of Risks to Human 

Reproduction (CERHR) Expert 

Panel identified a critical data 

need for multi-generational experimental animal studies to assess the long-term effects of 

prenatal and postnatal exposures on postnatal development 

including developmental 

neurotoxicity, reproductive function, and carcinogenicity.

No experimental animal toxicity 

studies at this time; human 

studies currently being considered by the NIH and other federal agencies may address outstanding safety concerns. 

L-beta-Methylaminoalanine 

[15920–93–1].

NIEHS ........................................... Natural product produced by 

cyanobacteria with localized 

and potentially widespread environmental occurrence; suspected risk factor for neurological disease(s); lack of adequate toxicity data.

—Absorption, distribution, metabolism, and elimination studies. 

—Neurotoxicity studies. 

—Biomolecular screening studies. 

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57360 Federal Register / Vol. 73, No. 192 / Thursday, October 2, 2008 / Notices 

TABLE 1—TESTING RECOMMENDATIONS FOR SUBSTANCES NOMINATED TO THE NTP FOR TOXICOLOGICAL STUDIES— 

Continued 

Substance [CAS No.] Nominated by 1 Nomination rationale Preliminary study 

recommendations 2

Triclosan [3380–34–5] ................... Private Individual and U.S. Food 

and Drug Administration.

Widespread use in consumer 

products; frequent and longterm exposure for all age 

groups; lack of adequate toxicity data for dermal exposures.

—Carcinogenicity studies via dermal administration. 

—Phototoxicity studies. 

—Reproductive toxicity studies. 

1 National Institute of Environmental Health Sciences (NIEHS). 

2The term ‘‘comprehensive toxicological characterization’’ in this table refers to the approximate scope of a research program to address toxicological data needs. The types of toxicological studies that would be considered by NTP staff during the conceptualization and design of a research program are biomolecular screening, in vitro mechanistic, in vitro and in vivo genotoxicity, absorption, disposition, metabolism, and elimination, short-term repeat dose (2–4 weeks) in vivo studies, subchronic toxicity (13–26 weeks), chronic toxicity (1–2 years), carcinogenicity in conventional or genetically modified rodent models, organ systems toxicity (immunotoxicity, reproductive and developmental toxicity, neurotoxicity), in 

vivo mechanistic, toxicokinetics, and other special studies as appropriate (e.g., chemistry, toxicogenomics, phototoxicity). 

To facilitate review of proposed 

research projects by the NTP BSC and 

the public, NTP staff developed a draft 

research concept document for each 

nomination recommended for study. A 

research concept is a brief document 

outlining the nomination or study 

rationale, and the significance, study 

approach, and expected outcome of a 

proposed research program tailored for 

each nomination. The purpose of these 

research concepts is to outline the 

general elements of a program of study 

that would address the specific issues 

that prompted the nomination, but also 

encompass studies that may address 

larger public health issues or topics in 

toxicology that could be addressed 

appropriately through studies on the 

nominated substance(s). Draft research 

concepts for the new nominations listed 

in Table 1 will be available on the NTP 

BSC meeting page (http:// 

ntp.niehs.nih.gov/go/165) by October 9, 

2008. 

Attendance and Registration 

The meeting is scheduled for 

November 20–21, 2008, beginning at 

8:30 a.m. on each day and continuing to 

5 p.m. on November 20 and on 

November 21 until adjournment. The 

meeting is open to the public with 

attendance limited only by the space 

available. Individuals who plan to 

attend are encouraged to register online 

at the NTP BSC meeting Web site 

(http://ntp.niehs.nih.gov/go/165) by 

November 13, 2008, to facilitate 

planning for the meeting. The NTP is 

making plans to videocast the meeting 

through the Internet at http:// 

www.niehs.nih.gov/news/video/live. 

Request for Comments 

Written comments submitted in 

response to this notice should be 

received by November 6, 2008. 

Comments will be posted on the NTP 

BSC meeting Web site and persons 

submitting them will be identified by 

their name and affiliation and/or 

sponsoring organization, if applicable. 

Persons submitting written comments 

should include their name, affiliation (if 

applicable), phone, e-mail, and 

sponsoring organization (if any) with 

the document. 

Time will be allotted during the 

meeting for the public to present oral 

comments to the NTP BSC on the 

agenda topics. Each organization is 

allowed one time slot per agenda topic. 

At least 7 minutes will be allotted to 

each speaker, and if time permits, may 

be extended to 10 minutes at the 

discretion of the NTP BSC chair. 

Persons wishing to present oral 

comments are encouraged to pre-register 

on the NTP meeting Web site. 

Registration for oral comments will also 

be available on-site, although time 

allowed for presentation by on-site 

registrants may be less than that for preregistered speakers and will be 

determined by the number of persons 

who register at the meeting. 

Persons registering to make oral 

comments are asked, if possible, to send 

a copy of their statement to the 

Executive Secretary for the NTP BSC 

(see ADDRESSES above) by November 13, 

2008, to enable review by the NTP BSC 

prior to the meeting. Written statements 

can supplement and may expand the 

oral presentation. If registering on-site 

and reading from written text, please 

bring 40 copies of the statement for 

distribution to the NTP BSC and NIEHS/ 

NTP staff and to supplement the record. 

Background Information on the NTP 

Board of Scientific Counselors 

The NTP BSC is a technical advisory 

body comprised of scientists from the 

public and private sectors that provides 

primary scientific oversight to the 

overall program and its centers. 

Specifically, the NTP BSC advises the 

NTP on matters of scientific program 

content, both present and future, and 

conducts periodic review of the program 

for the purpose of determining and 

advising on the scientific merit of its 

activities and their overall scientific 

quality. Its members are selected from 

recognized authorities knowledgeable in 

fields such as toxicology, pharmacology, 

pathology, biochemistry, epidemiology, 

risk assessment, carcinogenesis, 

mutagenesis, molecular biology, 

behavioral toxicology, neurotoxicology, 

immunotoxicology, reproductive 

toxicology or teratology, and 

biostatistics. Members serve overlapping 

terms of up to four years. NTP BSC 

meetings are held annually or 

biannually. 

Dated: September 23, 2008. 

Samuel H. Wilson, 

Acting Director, National Institute of 

Environmental Health Sciences and National 

Toxicology Program. 

[FR Doc. E8–23181 Filed 10–1–08; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Toxicology Program (NTP); 

Center for the Evaluation of Risks to 

Human Reproduction (CERHR); 

Announcement of Plans for Updated 

Evaluations of Genistein and Soy 

Formula; Request for Public 

Comments and Nomination of Expert 

Panel Members 

AGENCY: National Institute of 

Environmental Health Sciences 

(NIEHS), National Institutes of Health 

(NIH). 

ACTION: Notice of expert panel 

evaluation of the reproductive and 

developmental toxicities of genistein 

and soy formula. 

SUMMARY: The CERHR plans to convene 

an expert panel to conduct updated 

evaluations of the scientific evidence 

mstockstill on PROD1PC66 with NOTICES