<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 10-QSB

[x]      QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1934

         For the quarterly period ended February 28, 2005 or

[ ]      TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
         EXCHANGE ACT OF 1937

         For the transition period from _________ to _________

                        Commission file number: 001-32046


                             SIMULATIONS PLUS, INC.
                             ----------------------
                 (Name of small business issuer in its charter)


            CALIFORNIA                                           95-4595609
(State or other jurisdiction of                               (I.R.S. Employer
 Incorporation or Organization)                              identification No.)


                                1220 W. AVENUE J
                            LANCASTER, CA 93534-2902
           (Address of principal executive offices including zip code)

                                 (661) 723-7723
                (Issuer's telephone number, including area code)

                                 NOT APPLICABLE
      (Former Name, Former Address and Former Fiscal Year, if Changed Since
                                  Last Report)


Check whether the issuer: (1) filed all reports required to be filed by Section
13 or 15(d) of the Securities Exchange Act of 1934 during the past 12 months (or
for such shorter period that the registrant was required to file such reports),
and (2) has been subject to such filing requirements for the past 90 days.

Yes [x] No [ ]

The number of shares outstanding of the Issuer's common stock, par value $0.001
per share, as of April 14, 2005, was 3,626,643.

<PAGE>


                             SIMULATIONS PLUS, INC.
                                   FORM 10-QSB
                FOR THE QUARTERLY PERIOD ENDED FEBRUARY 28, 2005

                                Table of Contents

                          PART I. FINANCIAL INFORMATION

Item 1.  Financial Statements                                               Page
                                                                            ----

         Consolidated Balance Sheet at February 28, 2005 (unaudited)           2

         Consolidated Statements of Operations for the three months
          and six months ended February 28, 2005 and 29, 2004  (unaudited)     4

         Consolidated Statements of Cash Flows for the six months
          ended February 28, 2005 and 29, 2004 (unaudited)                     5

         Notes to Consolidated Financial Statements (unaudited)                7

Item 2.  Management's Discussion and Analysis or Plan of Operations

         General                                                              13

         Results of Operations                                                18

         Liquidity and Capital Resources                                      23

Item 3.  Quantitative and Qualitative Disclosures about Market Risk           23

Item 4.  Controls and Procedures                                              23

                           PART II. OTHER INFORMATION
Item 1.  Legal Proceedings                                                    25

Item 2.  Changes in Securities                                                25

Item 3.  Defaults upon Senior Securities                                      25

Item 4.  Submission of Matters to a Vote of Security Holders                  25

Item 5.  Other Information                                                    25

Item 6.  Exhibits and Reports on Form 8-K                                     26

Signature                                                                     27

Exhibit - Certifications                                                      28




<PAGE>
                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                      CONSOLIDATED BALANCE SHEET
                                                            at February 28, 2005
                                                                     (Unaudited)
--------------------------------------------------------------------------------

  ASSETS

CURRENT ASSETS
     Cash and cash equivalents (Note 6)                               $1,009,331
     Accounts receivable, net of allowance for doubtful accounts
         of $11,833 and present value discount of $4,697               1,507,605
     Inventory (Note 7)                                                  250,432
     Prepaid expenses and other current assets                           103,487
                                                                      ----------

            Total current assets                                       2,870,855



CAPITALIZED COMPUTER SOFTWARE DEVELOPMENT COSTS,
     net of accumulated amortization of $2,053,794 (Note 4)              697,494
PROPERTY AND EQUIPMENT, net (Note 8)                                      68,715
DEFERRED TAX (Note 5)                                                  1,396,000
OTHER ASSETS                                                              11,150
                                                                      ----------

                TOTAL ASSETS                                          $5,044,214
                                                                      ==========


   The accompanying notes are an integral part of these financial statements.

                                       2



<PAGE>
                                           SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                      CONSOLIDATED BALANCE SHEET
                                                            at February 28, 2005
                                                                     (Unaudited)
--------------------------------------------------------------------------------


                      LIABILITIES AND SHAREHOLDERS' EQUITY

CURRENT LIABILITIES
     Accounts payable                                               $   182,355
     Accrued payroll and other expenses                                 239,832
     Accrued warranty and service costs                                  28,084
     Current portion of deferred revenue                                 11,416
     Other current liabilities (Note 9)                                   4,667
                                                                    ------------

         Total current liabilities                                      466,354

DEFERRED REVENUE                                                         14,277

            Total liabilities                                           480,631
                                                                    ------------

COMMITMENTS AND CONTINGENCIES (Note 9)                                       --

SHAREHOLDERS' EQUITY (Note 10)
     Preferred stock, $0.001 par value
         10,000,000 shares authorized
         no shares issued and outstanding                                    --
     Common stock, $0.001 par value
         20,000,000 shares authorized
         3,621,043 shares issued and outstanding                          3,622
     Additional paid-in capital                                       5,076,354
     Accumulated deficit                                               (516,393)
                                                                    ------------

            Total shareholders' equity                                4,563,583
                                                                    ------------

                TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY          $ 5,044,214
                                                                    ============


   The accompanying notes are an integral part of these financial statements.

                                       3


<PAGE>
<TABLE>

                                                                               SIMULATIONS PLUS, INC. AND SUBSIDIARY
                                                                               CONSOLIDATED STATEMENTS OF OPERATIONS
                                                             for the three and six months ended February 28, and 29,
                                                                                                         (Unaudited)
--------------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                               Three months ended             Six months ended
                                                           ---------------------------   ---------------------------
                                                              2005           2004           2005            2004
                                                           ------------   ------------   ------------   ------------

<S>                                                        <C>            <C>            <C>            <C>
NET SALES                                                  $ 1,031,776    $ 1,368,750    $ 2,098,250    $ 2,507,483

COST OF SALES                                                  370,796        459,790        692,924        811,536
                                                           ------------   ------------   ------------   ------------

GROSS PROFIT                                                   660,980        908,960      1,405,326      1,695,947
                                                           ------------   ------------   ------------   ------------

OPERATING EXPENSES
     Selling, general, and administrative                      535,442        733,747      1,167,387      1,339,617
     Research and development                                  131,227        153,989        244,919        297,382
                                                           ------------   ------------   ------------   ------------

         Total operating expenses                              666,669        887,736      1,412,306      1,636,999
                                                           ------------   ------------   ------------   ------------

INCOME FROM OPERATIONS                                          (5,689)        21,224         (6,980)        58,948
                                                           ------------   ------------   ------------   ------------

OTHER INCOME (EXPENSE)
     Interest income                                            14,525         19,271         31,296         39,758
     Interest expense                                               --            (65)          (284)          (384)
     Gain on sale of assets                                         --             --          5,200             --
     Gain on currency exchange                                      --             --          2,111             --
                                                           ------------   ------------   ------------   ------------

         Total other income (expense)                           14,525         19,206         38,323         39,374
                                                           ------------   ------------   ------------   ------------

INCOME BEFORE BENEFIT FROM (PROVISION FOR)
     INCOME TAXES                                                8,836         40,430         31,343         98,322

BENEFIT FROM (PROVISION FOR) INCOME TAXES
     Provision for income tax                                       --         (7,803)            --        (18,976)
     Change in valuation allowance                                  --             --             --             --
                                                           ------------   ------------   ------------   ------------

         Total benefit from (provision for) income taxes            --         (7,803)            --        (18,976)
                                                           ------------   ------------   ------------   ------------

NET INCOME                                                 $     8,836    $    32,627    $    31,343    $    79,346
                                                           ============   ============   ============   ============

BASIC EARNINGS PER SHARE                                   $      0.00    $      0.01    $      0.01    $      0.02
                                                           ============   ============   ============   ============

Diluted earnings per share                                 $      0.00    $      0.01    $      0.01    $      0.02
                                                           ============   ============   ============   ============

WEIGHTED-AVERAGE COMMON SHARES OUTSTANDING
     BASIC                                                   3,608,600      3,469,994      3,589,792      3,443,598
                                                           ============   ============   ============   ============

     DILUTED                                                 4,114,872      4,209,459      4,114,872      4,209,459
                                                           ============   ============   ============   ============


                     The accompanying notes are an integral part of these financial statements.

                                                          4
</TABLE>
<PAGE>
<TABLE>
                                                            SIMUATIONS PLUS, INC. AND SUBSIDIARY
                                                           CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                   for the six months ended February 28, and 29,
                                                                                     (Unaudited)
-----------------------------------------------------------------------------------------------
<CAPTION>

                                                                       2005            2004
                                                                    ------------   ------------
<S>                                                                 <C>            <C>
CASH FLOWS FROM OPERATING ACTIVITIES
    Net income                                                      $    31,343    $    79,346
    Adjustments to reconcile net income to net cash
       provided by operating activities
         Depreciation and amortization of property and
           equipment                                                     21,518         19,512
         Amortization of capitalized software development
           costs                                                         77,810        109,178
         (Gain) on sale of assets                                        (5,200)            --

         (Increase) decrease in
           Accounts receivable                                          197,429       (176,825)
           Inventory                                                    108,158        (37,750)
           Other assets                                                  12,557         10,340
         Increase (decrease) in
           Accounts payable                                              29,469         (1,028)
           Accrued payroll and other expenses                            22,530        (19,778)
           Accrued bonuses to officers                                  (77,626)      (133,538)
           Accrued income taxes                                          (1,600)            --
           Accrued warranty and service costs                            (4,412)        (5,672)
           Deferred revenue                                              (5,708)        (9,308)
                                                                    ------------   ------------

              Net cash provided by (used in) operating activities       406,268       (165,523)
                                                                    ------------   ------------

CASH FLOWS FROM INVESTING ACTIVITIES
    Purchases of property and equipment                                 (27,401)       (17,906)
    Sale of property and equipment                                        8,735            379
    Capitalized computer software development costs                    (198,824)       (92,676)
                                                                    ------------   ------------

              Net cash used in investing activities                    (217,490)      (110,203)
                                                                    ------------   ------------

CASH FLOWS FROM FINANCING ACTIVITIES
    Payments on capitalized lease obligations                                --         (2,489)
    Proceeds from the exercise of stock options                          86,287         74,878
                                                                    ------------   ------------

              Net cash provided by (used in) financing activities        86,287         72,389
                                                                    ------------   ------------


           The accompanying notes are an integral part of these financial statements.

                                                5

<PAGE>
                                                            SIMUATIONS PLUS, INC. AND SUBSIDIARY
                                                           CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                   for the six months ended February 28, and 29,
                                                                                     (Unaudited)
-----------------------------------------------------------------------------------------------



                Net increase (decrease) in cash and cash
                  equivalents                                       $   275,065    $  (203,337)

CASH AND CASH EQUIVALENTS, BEGINNING OF YEAR                            734,266        260,733
                                                                    ------------   ------------

CASH AND CASH EQUIVALENTS, END OF QUARTER                           $ 1,009,331    $    57,396
                                                                    ============   ============


SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION

    INTEREST PAID                                                   $       284    $       384
                                                                    ============   ============

    INCOME TAXES PAID                                               $     1,600    $    47,000
                                                                    ============   ============


           The accompanying notes are an integral part of these financial statements.

                                                6
</TABLE>

<PAGE>

                             SIMULATIONS PLUS, INC.
                     NOTES TO CONDENSED FINANCIAL STATEMENTS
                                   (Unaudited)


Note 1: GENERAL

As contemplated by the Securities and Exchange Commission under Item 310(b) of
Regulation S-B, the accompanying financial statements and footnotes have been
condensed and therefore do not contain all disclosures required by generally
accepted accounting principles. The interim financial data are unaudited;
however, in the opinion of Simulations Plus, Inc. ("we", "our"), the interim
data include all adjustments, consisting only of normal recurring adjustments,
necessary for a fair statement of the results for the interim periods. Results
for interim periods are not necessarily indicative of those to be expected for
the full year.

Note 2: CRITICAL ACCOUNTING POLICIES

Our consolidated financial statements and accompanying notes are prepared in
accordance with accounting principles generally accepted in the United States of
America. Preparing financial statements requires management to make estimates
and assumptions that affect the reported amounts of assets, liabilities,
revenue, and expenses. These estimates and assumptions are affected by
management's application of accounting policies. Actual results could differ
from those estimates. Critical accounting policies for us include revenue
recognition (see Note 3), accounting for capitalized software development costs
(see Note 4), and accounting for income taxes (see Note 5).

Note 3: REVENUE RECOGNITION

We account for the licensing of software in accordance with American Institute
of Certified Public Accountants (AICPA) Statement of Position (SOP) 97-2,
"SOFTWARE REVENUE RECOGNITION". The application of SOP 97-2 requires judgment,
including whether a software arrangement includes multiple elements, and if so,
whether vendor-specific objective evidence (VSOE) of fair value exists for those
elements.

The end users receive certain elements of our products over a period of time.
These elements include free post-delivery telephone support and the right to
receive unspecified upgrades/enhancements. In accordance with SOP 97-2, we have
evaluated these agreements and we have recognized the entire license fee on the
date the software is delivered to and accepted by the customer. In order to
recognize the fee in this manner, we have met all the criteria required,
including:

o    The Post Contract Customer Support ("PCS") fee is included in the initial
     licensing fee,
o    The PCS included with the license is for one year or less,
o    The estimated cost of providing the PCS during the arrangement is
     insignificant, and
o    Unspecified upgrades/enhancements during the PCS arrangements have been and
     are expected to continue to be minimal and infrequent.


                                       7

<PAGE>

Changes to the elements in a software arrangement, the ability to identify VSOE
for those elements, the fair value of the respective elements, the costs
associated with providing PCS and changes to a product's estimated life cycle
could materially impact the amount of earned and unearned revenue. Judgment is
also required to assess whether future releases of certain software represent
new products or upgrades and enhancements to existing products.

From time to time, we offer certain customers multi-year contracts with extended
payment terms. SOP 97-2 requires us to evaluate these contracts to determine if
they qualify for recognition of revenue in a manner similar to our one-year
contracts. On these contracts, we evaluate the collection and concession history
with these customers and products to overcome the presumption that revenue
should be recognized in line with cash collections. To date, we have recognized
these contracts on delivery to and acceptance by the customer of the product.
Substantial judgment is required in evaluating the relevant history and contract
economics of these extended contracts, and could materially impact recorded
revenue and unearned revenue in our financial statements.

Note 4: CAPITALIZED COMPUTER SOFTWARE DEVELOPMENT COSTS

Capitalized computer software development costs are capitalized in accordance
with SFAS No. 86, "Accounting for the Cost of Computer Software to be Sold,
Leased, or Otherwise Marketed". Capitalization of software development costs
begins upon the establishment of technological feasibility and is discontinued
when the product is available for sale. The establishment of technological
feasibility and the ongoing assessment for recoverability of capitalized
software development costs require considerable judgment by management
including, but not limited to, technological feasibility, anticipated future
gross revenues, estimated economic life, and changes in software and hardware
technologies. Any changes to these estimates could materially impact the amount
of amortization expense, research and development expense recognized in the
consolidated statement of operations and the amount recognized as capitalized
software development costs in the consolidated balance sheet.

Amortization of capitalized software development costs is provided on a
product-by-product basis on the straight-line method over the estimated economic
life of the products, which varies product to product, not exceeding five years.
Management periodically compares estimated net realizable value by product with
the amount of software development costs capitalized for that product to ensure
the amount capitalized is recoverable through revenues. Any excess of
development costs to expected net realizable value is expensed at that time.

We have reassessed economic life of our pharmaceutical software based on our
actual experience, and we have determined that the estimated economic life of
the products should be five years starting at September 1, 2004. Accordingly, we
began amortizing the net book value of capitalized software development costs
over a sixty-month period using the straight-line method. As a result, we
amortized our pharmaceutical software development costs for $18,667 in the
second quarter of fiscal year 2005. If we had not changed our expected economic
life, we would have amortized $31,311.

                                       8

<PAGE>

Note 5: INCOME TAX

SFAS No. 109, "ACCOUNTING FOR INCOME TAXES", establishes financial accounting
and reporting standards for the effect of income taxes. The objectives of
accounting for income taxes are to recognize the amount of taxes payable or
refundable for the current year and deferred tax liabilities and assets for the
future tax consequences of events that have been recognized in an entity's
financial statements or tax returns. Judgment is required in assessing the
future tax consequences of events that have been recognized in our financial
statements or tax returns. Fluctuations in the actual outcome of these future
tax consequences could materially impact our financial position or our results
of operations.

Note 6: ACCOUNTS RECEIVABLE

We maintain an allowance for doubtful accounts for estimated losses that may
arise if any of its customers are unable to make required payments. We
specifically analyze the age of customer balances, historical bad debt
experience, customer credit-worthiness, and changes in customer payments terms
when making estimates of the uncollectability of our trade accounts receivable
balances. If we determine that the financial conditions of any of its customers
deteriorated, whether due to customer specific or general economic issues,
increase in the allowance may be made. Accounts receivable are written off when
all collection attempts have failed.

Our long-term receivables are discounted at the present value. The discount is
amortized over the life of the receivable and recognized as interest income. As
of February 28, 2005, the unamortized discount amount on such receivable was
$4,697. The discounted balance of receivables of $539,303 is due to be collected
before the end of fiscal year 2005.

Note 7: INVENTORY

Inventory is stated at the lower of cost (first-in, first-out basis) or market,
and consists of computers and peripheral computer equipment.

Note 8: PROPERTY AND EQUIPMENT

Furniture and equipment as of February 28, 2005 consisted of the following:

         Equipment                                                  $    98,885
         Computer equipment                                             364,578
         Furniture and fixtures                                          52,704
         Leasehold improvements                                          38,215
                                                                    ------------
                                                                        554,382
         Less accumulated depreciation and amortization                (485,667)
                                                                    ------------
                                                                    $    68,715
                                                                    ============


                                       9

<PAGE>

Note 9: STOCKHOLDERS' EQUITY

Stock Option Plan

In September 1996, the Board of Directors adopted and the shareholders approved
the 1996 Stock Option Plan (the "Option Plan") pursuant to which a total of
250,000 shares of common stock were reserved for issuance. In March 1999, the
shareholders approved an increase in the number of shares that may be granted
under the Option Plan to 500,000. In February 2000, the shareholders approved
the number of shares to be granted under the Option Plan to be 1,000,000 shares.
Furthermore, in December 2000, the shareholders approved an increase in number
of shares that may be granted under the Option Plan to 1,250,000. The Option
Plan terminates in 2006, subject to earlier termination by the Board of
Directors. On February 18, 2005 at an annual shareholders meeting, the
shareholders approved an additional 250,000 shares to be reserved for issuance
under the 1996 Stock Option Plan.

As of February 28, 2005, options to purchase 981,316 shares have been issued and
were outstanding to various employees at an exercise price equal to the fair
market value of our stock price at the date of each grant, with five-year
vesting periods. Also, in accordance with the by-laws of the corporation, a
total of 8,206 options to purchase shares have been issued to the Board of
Directors at exercise prices ranging from $1.20 to $5.25, with a three-year
vesting period. During the first six months of fiscal year 2005, 56,600 options
were exercised by employees.

Note 10: EARNINGS PER SHARE

The Company utilizes SFAS No. 128, "Earnings per Share." Basic earnings (loss)
per share is computed by dividing income (loss) available to common stockholders
by the weighted-average number of common shares outstanding. Diluted earnings
(loss) per share is computed similar to basic earnings (loss) per share except
that the denominator is increased to include the number of additional common
shares that would have been outstanding if the potential common shares had been
issued and if the additional common shares were dilutive. Common equivalent
shares are excluded from the computation if their effect is anti-dilutive. The
Company's common share equivalents consist of stock options.

Note 11:  STOCK-BASED COMPENSATION

SFAS No. 123, "Accounting for Stock-Based Compensation," establishes and
encourages the use of the fair-value-based method of accounting for stock-based
compensation arrangements under which compensation cost is determined using the
fair value of stock-based compensation determined as of the date of grant and is
recognized over the periods in which the related services are rendered. The
statement also permits companies to elect to continue using the current
intrinsic value accounting method specified in Accounting Principles Board
("APB") Opinion No. 25, "Accounting for Stock Issued to Employees," to account
for stock-based compensation. The Company has elected to use the intrinsic
value-based method and has disclosed the pro forma effect of using the
fair-value-based method to account for its stock-based compensation.


                                       10

<PAGE>

The table below represents a reconciliation of the company's pro forma net
income giving effect to the estimated compensation expense related to stock
options that would have been reported if the Company utilized the fair value
method:

<TABLE>
                                                                Six           Six
                                                               Months        Months
                                                                2005          2004
                                                             -----------   -----------
<S>                                                          <C>
Net income
     As reported                                             $   31,343    $   79,346
         Stock based employee compensation cost, net of
            related tax effects, that would have been
            included in the determination of net income
            if the fair value method had been applied          (126,471)     (129,138)
                                                             -----------   -----------

                  PRO FORMA NET INCOME (LOSS)                $  (95,128)   $  (49,792)
                                                             ===========   ===========

Earnings(loss) per common share
         Basic - as reported                                 $     0.01    $     0.02
         Basic - Pro forma                                   $    (0.03)   $    (0.01)

         Diluted - as reported                               $     0.01    $     0.02
         Diluted - Pro forma                                 $    (0.02)   $    (0.01)


Note 12:  SEGMENT AND GEOGRAPHIC REPORTING

The Company accounts for segments and geographic revenues in accordance with
SFAS No. 131, "Disclosure about Segments of an Enterprise and Related
Information." The Company's reportable segments are strategic business units
that offer different products and services. Results for each segment and
consolidated results are as follows for the six months ended February 28, 2005
and February 29, 2004:

                                                    February 28, 2005
-------------------------------------------------------------------------------------------------------------
                                   Simulations Plus,      Words +, Inc.       Eliminations         Total
                                          Inc
---------------------------------- ------------------- ------------------- ------------------ ---------------
Net Sales                                     933,602           1,164,648                          2,098,250
---------------------------------- ------------------- ------------------- ------------------ ---------------
Income (loss) from operations                 (37,533)             30,553                            (6,980)
---------------------------------- ------------------- ------------------- ------------------ ---------------
Identifiable assets                         5,521,678           1,246,860        (1,724,324)       5,044,214
---------------------------------- ------------------- ------------------- ------------------ ---------------
Capital expenditures                            5,053              22,348                             27,401
---------------------------------- ------------------- ------------------- ------------------ ---------------
Depreciation and Amortization                   7,102              14,416                             21,518
---------------------------------- ------------------- ------------------- ------------------ ---------------



                                       11


<PAGE>

                                                         February 29, 2004
-------------------------------------------------------------------------------------------------------------
                                   Simulations Plus,     Words +, Inc.       Eliminations         Total
                                          Inc
---------------------------------- ------------------- ------------------- ------------------ ---------------
Net Sales                                   1,384,557           1,122,926                          2,507,483
---------------------------------- ------------------- ------------------- ------------------ ---------------
Income (loss) from operations                 311,768           (241,820)                             79,346
---------------------------------- ------------------- ------------------- ------------------ ---------------
Identifiable assets                         4,571,061             984,293        (1,442,630)       4,112,724
---------------------------------- ------------------- ------------------- ------------------ ---------------
Capital expenditures                            1,981              15,925                             17,906
---------------------------------- ------------------- ------------------- ------------------ ---------------
Depreciation and Amortization                   7,548              11,964                             19,512
---------------------------------- ------------------- ------------------- ------------------ ---------------

In addition, the Company allocates revenues to geographic areas based on the
locations of its customers. Geographical revenues for the six months ended
February 28, 2005 and February 29, 2004 were as follows (in thousands):

                                                       February 28, 2005
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
                                   North                                                 South
                                  America          Europe       Asia       Oceania       America      Total
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Simulations Plus, Inc.                    514          209          210          -0-          -0-        933
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Words+, Inc.                            1,009          111           33           12          -0-      1,165
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Total                                   1,523          320          243           12          -0-      2,098
------------------------------ =============== ============ ============ ============ ============ ==========

                                                      February 29, 2004
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
                                    North                                                 South
                                   America        Europe        Asia        Oceania      America      Total
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Simulations Plus, Inc.                    530          434          420          -0-          -0-      1,384
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Words+, Inc.                              964          103           37           14            5      1,123
------------------------------ --------------- ------------ ------------ ------------ ------------ ----------
Total                                   1,494          537          457           14            5      2,507
------------------------------ =============== ============ ============ ============ ============ ==========
</TABLE>


Note 13:  SUBSEQUENT EVENT

Since March 1, 2005, an additional 5,600 stock options to purchase shares have
been exercised by employees.



                                       12


<PAGE>


Item 2. Management's Discussion and Analysis or Plan of Operations
------------------------------------------------------------------

FORWARD-LOOKING STATEMENTS

CERTAIN STATEMENTS IN THIS QUARTERLY REPORT ON FORM 10-QSB, OR THE "REPORT," ARE
"FORWARD-LOOKING STATEMENTS." THESE FORWARD-LOOKING STATEMENTS INCLUDE, BUT ARE
NOT LIMITED TO, STATEMENTS ABOUT THE PLANS, OBJECTIVES, EXPECTATIONS AND
INTENTIONS OF SIMULATIONS PLUS, INC., A CALIFORNIA CORPORATION (REFERRED TO IN
THIS REPORT AS THE "COMPANY") AND OTHER STATEMENTS CONTAINED IN THIS REPORT THAT
ARE NOT HISTORICAL FACTS. FORWARD-LOOKING STATEMENTS IN THIS REPORT OR HEREAFTER
INCLUDED IN OTHER PUBLICLY AVAILABLE DOCUMENTS FILED WITH THE SECURITIES AND
EXCHANGE COMMISSION, OR THE "COMMISSION," REPORTS TO OUR STOCKHOLDERS AND OTHER
PUBLICLY AVAILABLE STATEMENTS ISSUED OR RELEASED BY US INVOLVE KNOWN AND UNKNOWN
RISKS, UNCERTAINTIES AND OTHER FACTORS WHICH COULD CAUSE OUR ACTUAL RESULTS,
PERFORMANCE (FINANCIAL OR OPERATING) OR ACHIEVEMENTS TO DIFFER FROM THE FUTURE
RESULTS, PERFORMANCE (FINANCIAL OR OPERATING) OR ACHIEVEMENTS EXPRESSED OR
IMPLIED BY SUCH FORWARD-LOOKING STATEMENTS. SUCH FUTURE RESULTS ARE BASED UPON
MANAGEMENT'S BEST ESTIMATES BASED UPON CURRENT CONDITIONS AND THE MOST RECENT
RESULTS OF OPERATIONS. WHEN USED IN THIS REPORT, THE WORDS "EXPECT,"
"ANTICIPATE," "INTEND," "PLAN," "BELIEVE," "SEEK," "ESTIMATE" AND SIMILAR
EXPRESSIONS ARE GENERALLY INTENDED TO IDENTIFY FORWARD-LOOKING STATEMENTS,
BECAUSE THESE FORWARD-LOOKING STATEMENTS INVOLVE RISKS AND UNCERTAINTIES. THERE
ARE IMPORTANT FACTORS THAT COULD CAUSE ACTUAL RESULTS TO DIFFER MATERIALLY FROM
THOSE EXPRESSED OR IMPLIED BY THESE FORWARD-LOOKING STATEMENTS, INCLUDING OUR
PLANS, OBJECTIVES, EXPECTATIONS AND INTENTIONS AND OTHER FACTORS.

GENERAL

BUSINESS
--------

Simulations Plus, Inc. (the "Company" or "Simulations Plus", or "we" or "our")
and its wholly owned subsidiary, Words+, Inc. ("Words+") produce different types
of products: (1) Simulations Plus, incorporated in 1996, develops and produces
modeling and simulation software for use in pharmaceutical research and for
education, and also provides contract research services to the pharmaceutical
industry, and (2) Words+, founded in 1981, produces computer software and
specialized hardware for use by persons with disabilities, as well as a personal
productivity software program called Abbreviate! for the retail market.

SIMULATIONS PLUS
----------------

PRODUCTS
--------

We currently offer four software products for pharmaceutical research:
GastroPlus(TM), DDDPlus(TM), ADMET Predictor(TM), and ADMET Modeler(TM).

GastroPlus is a computer program that simulates how drugs are absorbed in the
human gastrointestinal tract and in a number of standard laboratory animals. The
simulation involves pharmacokinetics (what happens to the drug when it gets into
the body) and pharmacodynamics (what happens to the body when the drug gets into
the body). The basic absorption simulation has equations for the movement of the
drug through the gastrointestinal tract, how fast it dissolves in the stomach
and intestines, whether it is converted to a different molecular form by
chemical reactions or by metabolism by enzymes in the gastrointestinal tract,
and how fast it is absorbed through the intestinal wall into the blood stream.
With additional inputs, it also simulates the amount of drug in the blood plasma
versus time, and how the drug affects the body, such as reducing pain, reducing
blood pressure, reducing depression, and adverse side effects.

                                       13



<PAGE>

We believe GastroPlus is the "gold standard" for simulation of oral drug
absorption in the pharmaceutical industry. In addition to virtually every major
pharmaceutical company, recent sales have included a growing number of generic
drug companies and drug delivery companies (companies that design the tablet or
capsule for a drug compound that was developed by another company). Although
these companies are considerably smaller than the pharmaceutical giants, they
can also save considerable time and money using our software tools. We believe
this part of the industry, which includes hundreds of companies, represents
major growth potential for GastroPlus.

We are aware that other companies have developed competitive software; however,
based on customer feedback, we believe that the competitive threat to GastroPlus
is limited. We believe that the Metabolism and Transporter Module, the PDPlus
module, and the ongoing upgrades we have made to the core simulation have been
significant advances in the state-of-the-art of oral drug absorption,
pharmacokinetics, and pharmacodynamics analysis.

The PBPKPlus(TM) module has been in extended beta testing for a number of months
and we believe is now within a few weeks of release. This powerful module will
further extend the utility of GastroPlus within the industry by simulating the
amount of drug reaching specific tissues in human and laboratory animals. With
the release of this new module, we are also incorporating a number of other
major changes to the user interface and program capabilities. As a result, this
release has been delayed longer than we had originally planned; however, we
believe that this next version (GastroPlus 5.0) will be well worth the wait.

We announced the release of our fourth core product, DDDPlus (Dose
Disintegration and Dissolution Plus), in February 2005. DDDPlus simulates how
different tablets and capsules disintegrate and dissolve during in vitro
(laboratory) dissolution experiments. The program also simulates the effects of
changing formulation excipients (additives that are not the active drug), and
changing the experimental apparatus and fluids used in the experiment. We
believe this tool will be a valuable asset for formulation scientists as they
search for optimum formulations that provide desirable properties at minimum
cost, as well as optimum experimental conditions under which to measure
disintegration and dissolution to best predict what will happen in human. The
market for this tool includes hundreds of drug delivery companies as well as all
pharmaceutical and biotech companies.

Our recognized expertise in oral absorption and pharmacokinetics is evidenced by
the fact that our staff members have been invited speakers or presenters at over
40 prestigious scientific meetings worldwide in the past three years. We also
conduct contracted studies for customers who prefer to have studies run by our
scientists rather than to license our software and train someone to use it.

In addition to simulation software, we produce software that consists of
statistically significant numerical models that predict various properties of
chemical compounds from just their molecular structures. ADMET Predictor(TM)
(formerly known as QMPRPlus(TM)) provides estimates for approximately 50
properties of new drug-like molecules with only their structures as input. The
ability to predict many properties from just a structure drawing enables
researchers to eliminate large numbers of compounds before expensive testing,
saving considerable time and money.

Recent product improvements included an advanced prediction of ionization
constants ("pKa's") for molecules, which tells chemists whether the molecules
will ionize (add or give up hydrogen atoms) at different pH levels in the body.
Ionization is especially important because it has a major effect on some other
properties, like solubility. ADMET Predictor is now one of the few programs
available in the world that provides accurate prediction of pKas, and we believe
the predictive accuracy of the pKa model in ADMET Predictor is unsurpassed.

                                       14



<PAGE>

With the recent release of ADMET Predictor 1.0, we also added an important new
capability for toxicity prediction. Toxicity prediction was identified by the
U.S. Food and Drug Administration as a critical need in a white paper released
in March 2004. We released our first toxicity prediction in the fourth quarter,
which predicts whether new molecules are expected to bind to the estrogen
receptor. The new capability provides six different toxicity models based on
data sets released to the public domain by the U.S. Environmental Protection
Agency and the U.S. Food and Drug Administration in 2004. New toxicity models
are in development and will be released as we complete them as upgrades to ADMET
Predictor.

With these new capabilities, we believe ADMET Predictor combines the most
comprehensive and accurate set of predictions for Absorption, Distribution,
Metabolism, Excretion and Toxicity (ADMET) available today.

GastroPlus and/or ADMET Predictor have been licensed by virtually every major
pharmaceutical company and a growing number of smaller companies in the U.S.,
Europe, and Japan. Our number of customers has grown continuously since our
first product releases in 1998 and continues to grow each quarter.

ADMET Modeler(TM) (formerly QMPRchitect(TM)), was originally released in July of
2003. This powerful program is used to generate the predictive models used in
ADMET Predictor in a small fraction of the time once required to build these
models. For example, the six new toxicity models in ADMET Predictor were
developed in a matter of a few weeks. Most of that time was spent in cleaning up
the databases (which seem to always contain a number of errors). Prior to the
availability of ADMET Modeler, we would have needed as much as three months for
each one of the six models to obtain similar results, or a total of about 18
months. New toxicity models are in development at this time, and will be
released as upgrades to ADMET Predictor as they are completed.

Pharmaceutical companies spend enormous amounts of money conducting a wide
variety of experiments each year. Using such data to build predictive models
provides a second return on investment; however, in the past, model-building has
traditionally been a tedious activity that required a specialist. With ADMET
Modeler, scientists with no model-building experience can use their own
experimental data to quickly create very high quality predictive models.

We continue to enhance GastroPlus, DDDPlus, ADMET Predictor, and ADMET Modeler,
and we are developing new core products to add to our catalog of software for
pharmaceutical research. Another core product scheduled to be released in 2005
is MembranePlus(TM), which is described further below.

In addition to our pharmaceutical software, we also produce a set of
award-winning science experiment simulations (computer programs for Windows and
Macintosh computers) for middle school and high school students under the
umbrella name of FutureLab(TM). These simulations incorporate the equations of
chemistry and physics for each experiment (optics, electrical circuits, gravity,
universal gravitation, and ideal gases), and allow students to design and
conduct their own experiments in a virtual laboratory environment. Although
development of FutureLab software was discontinued in 1998, low-level sales have
continued through distributors in the U.S., U.K. Australia, and New Zealand.

                                       15



<PAGE>

CONTRACT RESEARCH SERVICES
--------------------------

We offer contract research services to the pharmaceutical industry in the area
of gastrointestinal absorption, pharmacokinetics, structure-property model
building, and related technologies. These studies provide us an additional
source of revenue, as well as a means to introduce our software products to new
customers. Such studies are also beneficial to us to validate and enhance our
products by studying actual data in the pharmaceutical industry. In the fourth
quarter of fiscal year 2004, we received our largest study contract to date. We
believe the results of that study saved our customer from conducting a human
trial that would have inevitably failed. The business of contracted studies is
growing, and we believe it could contribute significantly to our revenues and
earnings; however, we plan to control growth in this area such that it does not
adversely impact our product development stream.

PHARMACEUTICAL SIMULATIONS SOFTWARE PRODUCT DEVELOPMENT
-------------------------------------------------------

In the area of simulation software for pharmaceutical research, we are
developing additional capabilities for GastroPlus, DDDPlus, ADMET Predictor, and
ADMET Modeler. Although all of our development work cannot be disclosed for
competitive reasons, some of our development efforts include:

(1) PBPKPlus(TM) Module

The PBPKPlus Module for GastroPlus was demonstrated at the American Association
of Pharmaceutical Scientists conference in early November 2004. We expect the
module to be released for sale in the third quarter. This module enables
researchers to predict the amount of drug that reaches different body tissues
and organs. This is an important new capability because it is one of the most
promising technologies for predicting human pharmacokinetics from animal data
(pharmacokinetics refers to what happens to the drug after it enters the body).
With actual human data, this capability will enable scientists to predict the
concentration of drug in various body tissues, which should contribute to a
better understanding of both therapeutic and adverse effects. Without the
ability to predict these effects, clinical trial costs can soar when trials must
be repeated to determine proper dosing levels. We believe the integration of the
GastroPlus absorption model with a complete PBPK capability provides the most
comprehensive simulation capability currently available. This capability was
developed in response to customer requests from several of the largest
pharmaceutical companies in the world, and two large companies have been
involved in beta testing the new version.

(2) Multiple Particle Size Dissolution Model

The current dissolution model in GastroPlus uses a single "effective" particle
size. While this has adequately represented the dissolution of most tablets,
capsules, and suspensions to date, formulation researchers know that real dosage
forms do not consist of particles that are all one size. Instead, there is a
distribution of particle sizes from smaller than average to larger than average.
Smaller particles dissolve faster than larger particles. For some drugs, this
results in dissolution behavior that is not well-modeled with a single effective
particle size. This new model will allow formulation researchers to assess the
effects of different particle size distributions on dissolution and absorption.
The multiple particle size model has already been demonstrated in our DDDPlus
software. We plan to incorporate it into a Formulation Module for GastroPlus in
calendar 2005.

(3) ADMET Predictor(TM) upgrades

We will continue to add new molecular descriptors and new predicted ADMET
properties to ADMET Predictor. We recently announced the release of ADMET
Predictor 1.0 with structure drawing depiction and six toxicity predictions, as
well as improved pKa prediction and other user convenience improvements. We
expect to add a number of user conveniences as well as additional toxicity
models and prediction of other ADMET properties in the coming months.


                                       16



<PAGE>

RESULTS OF OPERATIONS

COMPARISON OF THREE MONTHS ENDED FEBRUARY 28, 2005 AND FEBRUARY 29, 2004.

The following table sets forth our consolidated statements of operations (in
thousands) and the percentages that such items bear to net sales:

<TABLE>

                                                    ------------------------------------------------------------
                                                                        Three Months Ended
                                                    ------------------------------------------------------------
                                                               02/28/05                      02/29/04
                                                    ------------------------------- ----------------------------
<S>                                                         <C>              <C>         <C>              <C>
Net sales                                                   $ 1,032          100%        $ 1,369          100%
Cost of sales                                                   371           35.9           460           33.6
                                                    ---------------- -------------- ------------- --------------
Gross profit                                                    661           64.1           909           66.4
                                                    ---------------- -------------- ------------- --------------
Selling, general and administrative                             535           51.8           734           53.6
Research and development                                        131           12.7           154           11.2
                                                    ---------------- -------------- ------------- --------------
Total operating expenses                                        666           64.5           888           64.8
                                                    ---------------- -------------- ------------- --------------
Income (loss) from operations                                   (5)           (0.5)           21            1.5
                                                    ---------------- -------------- ------------- --------------
Other income (expenses)                                         14             1.4            19            1.4
                                                    ---------------- -------------- ------------- --------------
Net income before taxes                                          9             0.9            40            2.9
                                                    ---------------- -------------- ------------- --------------
Provision for income taxes                                       -               -             7            0.5
                                                    ---------------- -------------- ------------- --------------
Net income                                                    $  9             0.9%        $  33           2.4%
                                                    ================ ============== ============= ==============
</TABLE>


NET SALES

Consolidated net sales decreased $337,000, or 24.6%, to $1,032,000 in the second
fiscal quarter of 2005 (FY05) from $1,369,000 in the second fiscal quarter of
2004 (FY04). Our sales from pharmaceutical and educational software decreased
approximately $332,000, or 44.7%; and our Words+, Inc. subsidiary's sales
decreased approximately $5,000, or 0.8%, for the quarter. Management attributes
the decrease in pharmaceutical software sales primarily to the fact that we
received a two-year order for almost $500,000 during the second quarter of last
fiscal year, while no such order was received this year. Several orders that we
had expected in the first quarter were received during the second quarter, and
new customers were added during the second quarter; however, the total revenues
generated were less than during the second quarter of fiscal year 2004.

Management attributes the decrease in Words+ sales primarily a decline in sales
of our Freedom and MessageMate products, which were largely offset by increases
in sales of our "Say-it! SAM" and "TuffTalker" products,

COST OF SALES

Consolidated cost of sales decreased $89,000, or 19.4%, to $371,000 in the
second fiscal quarter of FY05 from $460,000 in the second fiscal quarter of
FY04. The percentage of cost of sales in the second fiscal quarter of FY05
increased 2.3% from the second fiscal quarter of FY04. For Simulations Plus,
cost of sales decreased $53,000, or 48.6%. A significant portion of cost of
sales is the systematic amortization of capitalized software development costs,
which decreased $30,000, or 61.2%, and a decrease in royalty expense of $23,000,
or 37.7% which represents royalty payments to TSRL. As a percentage, cost of
sales decreased from 14.7% in FY04 to 13.7% in FY05. Management attributes this
decrease in percentage of cost of sales primarily to a change in estimate of
pharmaceutical software product life, which, based on our demonstrated product
lives, we reassessed to be 5 years beginning with the first fiscal quarter of
FY05. Thus, quarterly amortization of capitalized software development costs
decreased.

For Words+, cost of sales decreased $36,000, or 10.3%. As a percentage, cost of
sales decreased 5.3% between the second fiscal quarter of FY05 and FY04.
Management attributes the percentage decrease in cost of sales for Words+
primarily to the price increases instituted as part of our restructuring of
Words+ in fiscal year 2004.

                                       17



<PAGE>

GROSS PROFIT

Consolidated gross profit decreased $248,000, or 27.3%, to $661,000 in the
second fiscal quarter of FY05 from $909,000 in the second fiscal quarter of
FY04. Management attributes this decrease to lower pharmaceutical software sales
which outweighed an increase in gross profit generated by Words+ products.

SELLING, GENERAL AND ADMINISTRATIVE EXPENSES

Consolidated selling, general and administrative expenses decreased $199,000, or
27.1%, to $535,000 in the second fiscal quarter of FY05 from $734,000 in the
second fiscal quarter of FY04. For Simulations Plus, selling, general and
administrative expenses decreased $48,000, or 13.9%. The major decreases in
expenses were insurance, legal, and accounting, which outweighed increases in
investor relation's fees, and salary increases along with payroll-related
expenses such as payroll taxes, and 401(k) matching contributions.

For Words+, expenses decreased $151,000, or 38.9%, due to reductions in salary
and payroll-related expenses such as health insurance, payroll taxes and 401(k)
matching contributions, and selling expenses. These decreases outweighed
increases in dues and subscriptions, and repairs.

RESEARCH AND DEVELOPMENT

We incurred approximately $210,000 of research and development costs for both
companies during the second fiscal quarter of FY05. Of this amount, $79,000 was
capitalized and $131,000 was expensed. In the second fiscal quarter of FY04, we
incurred $360,000 of research and development costs, of which $206,000 was
capitalized and $154,000 was expensed. The decrease of $150,000, or 41.7%, in
research and development expenditure from the second fiscal quarter of FY04 to
the second fiscal quarter of FY05 was due primarily to the purchase of Say-it!
SAM technology incurred in FY04, while no similar expense was experienced in
FY05.

OTHER INCOME (EXPENSE)

Net other income (expense) in the second fiscal quarter of FY05 decreased by
$5,000. This is due primarily to the decrease in the amortization of present
value discount on long-term receivables.

PROVISION FOR INCOME TAXES

Although the Company had a Net Operating Loss (NOL) carried forward which was
applied to the Company's Federal income tax liability, the State of California
suspended the NOL carry forward for two years beginning with fiscal years that
began after January 2003, resulting in a $7,000 tax due to the state of
California for the second quarter of FY04. We do not expect any tax due to the
state of California for the second quarter of FY05.

NET INCOME

Consolidated net income for the three months' operations decreased by $24,000,
or 72.7%, to $9,000 in the second quarter of FY05 compared to $33,000 in the
second quarter of FY04. Management attributes this decrease in profit primarily
to the decrease in pharmaceutical software and services sales and other income
which outweighed decreases in cost of sales, selling, general and administrative
expenses, research and development expenses, and provision for income taxes.


                                       18



<PAGE>

COMPARISON OF SIX MONTHS ENDED FEBRUARY 28, 2005 AND FEBRUARY 29, 2004.

The following table sets forth our consolidated statements of operations (in
thousands) and the percentages that such items bear to net sales:

<TABLE>
                                                                         Six Months Ended
                                                    ------------------------------------------------------------
                                                               02/28/05                      02/29/04
                                                    ------------------------------- ----------------------------
<S>                                                         <C>              <C>        <C>              <C>
Net sales                                                   $ 2,098          100%       $ 2,507          100%
Cost of sales                                                   693           33.0          811           32.4
                                                    ---------------- -------------- ------------- --------------
Gross profit                                                  1,405           67.0        1,696           67.6
                                                    ---------------- -------------- ------------- --------------
Selling, general and administrative                           1,167           55.6        1,340           53.4
Research and development                                        245           11.7          297           11.9
                                                    ---------------- -------------- ------------- --------------
Total operating expenses                                      1,412           67.3        1,637           65.3
                                                    ---------------- -------------- ------------- --------------
Income (loss) from operations                                   (7)          (0.3)           59            2.3
                                                    ---------------- -------------- ------------- --------------
Other income (expenses)                                         38            1.8            39            1.6
                                                    ---------------- -------------- ------------- --------------
Net income before taxes                                         31            1.5            98            3.9
                                                    ---------------- -------------- ------------- --------------
Provision for income taxes                                       -              -            19            0.8
                                                    ---------------- -------------- ------------- --------------
Net income                                                   $  31           1.5%         $  79            3.1%
                                                    ================ ============== ============= ==============
</TABLE>

NET SALES

Consolidated net sales decreased $409,000, or 16.3%, to $2,098,000 in the first
six months of FY05 from $2,507,000 in the first six months of FY04. Our sales
from pharmaceutical and educational software decreased approximately $451,000,
or 32.6%; however, our Words+, Inc. subsidiary's sales increased approximately
$42,000, or 3.7%, for the six months. Management attributes the decrease in
pharmaceutical software sales to three factors: (1) revenues from analytical
study contract revenues were zero in FY05, while we had $32,000 in study
contract revenues in FY04, (2) the amount of the new one-year global license in
FY05 was somewhat less than the amount we received from a multi-year "ADME
Partners" license in FY04, and (3) we received a two-year order worth just under
$500,000 in the second quarter of FY04, while no such order was received in the
second quarter of FY05. Despite these decreases, pharmaceutical revenues from
new customers increased in FY05, which we expect will expand future annual
license renewal revenues.

Management attributes the increase in Words+ sales primarily to the sales growth
in products of "Say-it! SAM" and "TuffTalker", which accounted for 39% of total
sales in FY05, compared with 7% of total sales in FY04. This increase outweighed
a decrease in Freedom product and MessageMates sales.

COST OF SALES

Consolidated cost of sales decreased $118,000, or 14.5%, to $693,000 in the
first six months of FY05 from $811,000 in the first six months of FY04. The
percentage of cost of sales in the first six months of FY05 is almost the same
as the first six months of FY04. For Simulations Plus, cost of sales decreased
$84,000, or 44.9%. A significant portion of cost of sales is the systematic
amortization of capitalized software development costs, which decreased $68,000,
or 72.3%. In addition, royalty expense decreased $16,000, or 16.1%. As a
percentage, cost of sales decreased from 13.5% in FY04 to 11.1% in FY05.
Management attributes this decrease in percentage of cost of sales primarily to
a change in estimate of pharmaceutical software product life, which we
reassessed to be 5 years beginning with this fiscal year. Thus, six months
amortization of capitalized software development costs decreased.

For Words+, cost of sales decreased $34,000, or 5.4%. As a percentage, cost of
sales decreased 4.9% between the first six months of FY05 and FY04. Management
attributes the percentage decrease in cost of sales for Words+ primarily to the
price increases instituted as part of our restructuring of Words+ in fiscal year
2004.

GROSS PROFIT

Consolidated gross profit decreased $291,000, or 17.2%, to $1,405,000 in the
first six months of FY05 from $1,696,000 in the first six months of FY04.
Management attributes this decrease to lower pharmaceutical software sales which
outweighed an increase in gross profit generated by Words+ products.

                                       19



<PAGE>

SELLING, GENERAL AND ADMINISTRATIVE EXPENSES

Consolidated selling, general and administrative expenses decreased $173,000, or
12.9%, to $1,167,000 in the first six months of FY05 from $1,340,000 in the
first six months of FY04. For Simulations Plus, selling, general and
administrative expenses increased $3,000, or 0.5%, which is almost the same. The
major increases in expenses were in the categories of investor relations fees,
and salary increases along with payroll-related expenses such as health
insurance, payroll taxes, and 401(k) matching contributions. These increases
outweighed decreases in commission expense, travel, and legal fees.

For Words+, expenses decreased $176,000, or 25.3%, due to a reduction in salary
and payroll-related expenses such as health insurance, payroll taxes and 401(k)
matching contributions, commission, and catalog expenses. These decreases
outweighed small increases in repairs, trade shows and travel expenses.

RESEARCH AND DEVELOPMENT

We incurred approximately $444,000 of research and development costs for both
companies during the first six months of FY05. Of this amount, $199,000 was
capitalized and $245,000 was expensed. In the first six months of FY04, we
incurred $550,000 of research and development costs, of which $253,000 was
capitalized and $297,000 was expensed. The decrease of $111,000, or 20.2%, in
research and development expenditure from the first six months of FY04 to the
first six months of FY05 was due primarily to the purchase of Say-it! SAM
technology incurred in FY04, while no such expense was incurred in FY05.

OTHER INCOME (EXPENSE)

The net of other income (expense) in the first six months of FY05 decreased by
$1,000. The amortization of present value discount on long-term receivables
decreased by $8,000, however we gained $5,000 on sale of equipment and $2,000 on
currency exchange.

PROVISION FOR INCOME TAXES

Although the Company had a Net Operating Loss (NOL) carried forward which was
applied to the Company's Federal income tax liability, the State of California
suspended the NOL carry forward for two years beginning with fiscal years that
began after January 2003, resulting in a $19,000 tax due to the state of
California for the first six months of FY04. We do not expect any tax due to the
state of California for the first six months of FY05.

NET INCOME

Consolidated net income for the six months' operations decreased by $48,000, or
60.8%, to $31,000 in the first six months of FY05 compared to $79,000 in the
first six months of FY04. Management attributes this decrease in profit
primarily to the decrease in sales and other income which outweighed decreases
in cost of sales, selling, general and administrative expenses, research and
development expenses, and provision for income taxes.

                                       20



<PAGE>


LIQUIDITY AND CAPITAL RESOURCES

The Company's principal sources of capital have been cash flows from its
operations and a bank line of credit. The Company has available a $500,000
revolving line of credit from a bank. Interest is payable on a monthly basis at
the bank's prime rate plus 1.5%. At February 28, 2005, the outstanding balance
under the revolving line of credit was zero. The revolving line of credit is
secured by the Company's assets, consisting of tangible personal property
(except goods in transit), is personally guaranteed by the Company's President,
and expires in May 2005.

The Company believes that existing capital and anticipated funds from operations
will be sufficient to meet its anticipated cash needs for working capital and
capital expenditures for the foreseeable future. Thereafter, if cash generated
from operations is insufficient to satisfy the Company's capital requirements,
the Company may have to sell additional equity or debt securities or obtain
expanded credit facilities. In the event such financing is needed in the future,
there can be no assurance that such financing will be available to the Company,
or, if available, that it will be in amounts and on terms acceptable to the
Company. If cash flows from operations became insufficient to continue
operations at the current level, and if no additional financing was obtained,
then management would restructure the Company in a way to preserve its
pharmaceutical and disability businesses while maintaining expenses within
operating cash flows.

Item 3. Quantitative and Qualitative Disclosures about Market Risk
------------------------------------------------------------------

Our risk from exposure to financial markets is limited to foreign exchange
variances and fluctuations in interest rates. We may be subject to some foreign
exchange risks. Most of our business transactions are in U.S. dollars, although
we generate significant revenues from customers overseas. The exception is that
we were compensated in Japanese yen by some Japanese customers. As a result, we
experienced a small gain from currency exchange in the first six months of FY05.
In the future, if foreign currency transactions increase significantly, then we
may mitigate this effect through foreign currency forward contracts whose
market-to-market gains or losses are recorded in "Other Income or expense" at
the time of the transaction. To date, exchange rate exposure has not resulted in
a material impact.

Item 4. Controls and Procedures
-------------------------------

(a)      EVALUATION OF DISCLOSURE CONTROLS AND PROCEDURES. As of the end of the
         period covered by this report, the Company carried out an evaluation,
         under the supervision and with the participation of the Company's
         management, including the Company's Chief Executive Officer and Chief
         Financial Officer, of the effectiveness of the design and operation of
         the Company's disclosure controls and procedures pursuant to Exchange
         Act Rule 13a-14. Based upon that evaluation, the Chief Executive
         Officer and Director of Finance concluded that the Company's disclosure
         controls and procedures are effective in timely alerting them to
         material information relating to the Company required to be included in
         the Company's periodic SEC filings.

(b)      CHANGES IN INTERNAL CONTROLS OVER FINANCIAL REPORTING. There was no
         change in Company's internal control over financial reporting during
         the Company's most recent fiscal quarter that has materially affected,
         or is reasonably likely to materially affect, the Company's Internal
         control over financial reporting.


                                       21



<PAGE>



                           PART II. OTHER INFORMATION

Item 1. Legal Proceedings
-------------------------

                  In the normal course of business, the Company is subject to
                  various lawsuits and claims. The Company believes that the
                  final outcomes of these matters, either individually or in the
                  aggregate, will not have a material effect on the financial
                  statements. The Company is not involved in any such litigation
                  at this time.

Item 2. Changes in Securities
-----------------------------
                  None.

Item 3. Defaults Upon Senior Securities
---------------------------------------
                  None.

Item 4. Submission of Matters to a Vote of Security Holders
-----------------------------------------------------------

On March 11, 2004, the Registrant held its annual meeting of shareholders. The
following proposals were submitted to a vote of security holders at the meeting.

1.  Election of directors
         Walter Woltosz
         Virginia Woltosz
         Dr. David Z. D'Argenio
         Dr. Richard Weiss

2. Ratification of the selection of Rose, Snyder, and Jacobs as the Company's
independent accountants.

3. To adopt amendment to 1996 Stock Option Plan

     The above proposals were approved and the results of the balloting at the
     meeting are summarized in the following table.

<TABLE>

     Proposal              Yes                No              Abstain           Withheld            Total
-------------------- ----------------- ------------------ ----------------- ----------------- ------------------
<S>     <C>                 <C>                                                       <C>             <C>
        (1)                 3,218,398                 --                --            10,000          3,228,398
-------------------- ----------------- ------------------ ----------------- ----------------- ------------------
        (2)                 3,215,098                800            12,500                --          3,228,398
-------------------- ----------------- ------------------ ----------------- ----------------- ------------------
        (3)                 2,279,011             54,761            14,596                --          2,348,368
-------------------- ----------------- ------------------ ----------------- ----------------- ------------------
</TABLE>


Item 5. Other Information
-------------------------
                  None.

Item 6. Exhibits and Reports on form 8-K
----------------------------------------

(a) Exhibits:

31.1-2   Certification of Chief Executive Officer and Chief Financial Officer
32       Certification pursuant to Sec. 906 of the Sarbanes-Oxley Act of 2002
99.1     Press release dated September 3, 2004.
         (Incorporated by reference to the Company's Form 8-K filed on
         September 3, 2004.)

(b) Reports on Form 8-K

         On September 3, 2004, Simulations Plus, Inc. issued a press release
         announcing changes in independent auditor. Following the press release,
         Form 8K was filed on September 3, 2004.

         On September 22, 2004, Simulations Plus, Inc. filed Form 8K/A revising
         our documents in response to SEC's comments regarding Form 8K filed on
         September 3, 2004.


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<PAGE>


                                    SIGNATURE

In accordance with Section 13 or 15 (d) of the Securities Exchange Act of 1934,
the Registrant caused this report to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Lancaster, State of California, on
April 14, 2005.

                                            Simulations Plus, Inc.

Date:  April 14, 2005                       By: /s/ MOMOKO BERAN
                                                --------------------------------
                                                Momoko Beran
                                                Chief Financial Officer


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