Registration Rights Agreement dated February 19, 2004



 EXHIBIT 4.8 
  

  
 $517,500,000 
  
 1.5% CONVERTIBLE SENIOR NOTES DUE 2024

  
 REGISTRATION RIGHTS AGREEMENT 
  
 DATED AS OF FEBRUARY 19, 2004 
  
 by and among 
  
 INVITROGEN CORPORATION 
  
 and 
  
 UBS SECURITIES LLC 
  
 BEAR, STEARNS & CO. INC. 
  








 This Registration Rights Agreement (this “Agreement”) is made and entered into as
of February 19, 2004 by and among Invitrogen Corporation, a Delaware corporation (the “Company”), and UBS Securities LLC and Bear, Stearns & Co. Inc. (each an “Initial Purchaser” and collectively,
the “Initial Purchasers”). The Company proposes to issue and sell to the Initial Purchasers (the “Initial Placement”) $450,000,000 in aggregate principal amount of its 1.5% Convertible Senior Notes due
2024 (the “Firm Convertible Notes”). The Company also proposes to issue and sell to the Initial Purchasers not more than $67,500,000 in aggregate principal amount of its 1.5% Convertible Senior Notes due 2024 (the
“Additional Convertible Notes” and, together with the Firm Convertible Notes, the “Notes”). As an inducement to the Initial Purchasers to enter into the purchase agreement, dated as of February 12,
2004 (the “Purchase Agreement”), and in satisfaction of a condition to the Initial Purchasers’ obligations thereunder, the Company agrees with the Initial Purchasers, (i) for the benefit of the Initial Purchasers and
(ii) for the benefit of the holders from time to time of the Notes whose names appear in the register maintained by the Registrar in accordance with the provisions of the Indenture (as defined in Section 1 hereof) (including the Initial Purchasers),
as follows: 
  
 SECTION 1. DEFINITIONS 
  
 Capitalized terms used herein without definition shall have their respective
meanings set forth in the Purchase Agreement. As used in this Agreement, the following capitalized defined terms shall have the following meanings: 
  
 “Act” means the Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder.

  
 “Affiliate” of any specified person
means any other person which, directly or indirectly, is in control of, is controlled by, or is under common control with, such specified person. For purposes of this definition, control of a person means the power, direct or indirect, to direct or
cause the direction of the management and policies of such person whether by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 
  
 “Agreement” means this Registration Rights Agreement.

  
 “Closing Date” has the meaning set
forth in the Purchase Agreement. 
  
 “Commission” means the Securities and Exchange Commission. 
  
 “Common Stock” means the common stock of the Company, par value $0.01 per share, issuable upon the conversion of the Notes. 
  
 “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations
of the Commission promulgated thereunder. 
  
 “Holder” has the meaning set forth in Section 2 hereof. 
  









 “Indenture” means the Indenture, dated as of February 19, 2004 between the
Company and the Trustee, relating to the Notes, as the same may be amended from time to time in accordance with the terms thereof. 
  
 “Initial Placement” has the meaning set forth in the preamble hereto. 
  
 “Majority Holders” means the Holders of a majority of
the aggregate principal amount of securities registered under a Shelf Registration Statement. 
  
 “Prospectus” means the prospectus included in any Shelf Registration Statement (including, without limitation, a prospectus that discloses information previously omitted from a prospectus filed
as part of an effective registration statement in reliance upon Rule 430A under the Act), as amended or supplemented by any prospectus supplement, with respect to the terms of the offering of any portion of Transfer Restricted Securities covered by
such Shelf Registration Statement, and all amendments and supplements to the Prospectus, including post-effective amendments. 
  
 “Shelf Registration” means a registration effected pursuant to Section 3 hereof. 
  
 “Shelf Registration Period” has the meaning set forth
in Section 3 hereof. 
  
 “Shelf Registration
Statement” means a “shelf” registration statement of the Company pursuant to the provisions of Section 3 hereof that covers some or all of the Transfer Restricted Securities as applicable, on an appropriate form under Rule 415
under the Act, or any similar rule that may be adopted by the Commission, amendments and supplements to such registration statement, including post-effective amendments, and in each case, including the Prospectus contained therein, all exhibits
thereto and all material incorporated therein by reference. 
  
 “Supplemental Delay Period” means any period commencing on the date of receipt by a Holder of Transfer Restricted Securities of any notice from the Company of the existence of any fact or event of the kind described
in Section 4(b)(2) hereof and ending on the date of receipt by such Holder of an amended or supplemented Shelf Registration Statement or Prospectus, as contemplated by Section 4(h) hereof, or the receipt by such Holder of written notice from the
Company (the “Advice”) that the use of the Prospectus may be resumed, and the receipt of copies of any additional or supplemental filings that are incorporated by reference in the Prospectus. 
  
 “Transfer Restricted Securities” means each Note and
the Common Stock issuable upon conversion thereof until (i) the date on which such Note or the Common Stock issuable upon conversion thereof has been effectively registered under the Act and disposed of in accordance with the Shelf Registration
Statement, (ii) the date on which such Note or Common Stock issuable upon conversion thereof is distributed to the public pursuant to Rule 144 under the Act (or any similar provision then in effect) or is salable pursuant to Rule 144(k) under the
Act or (iii) the date on which such Note or the Common Stock issuable upon conversion thereof ceases to be outstanding. 
  
 “Trustee” means the trustee with respect to the Notes under the Indenture. 
  

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 “Underwriter” means any underwriter of Notes in connection with an offering
thereof under a Shelf Registration Statement. 
  
 SECTION 2. HOLDERS

  
 A person is deemed to be a holder of Transfer Restricted
Securities (each, a “Holder”) whenever such person becomes the registered holder of such Transfer Restricted Securities under the Indenture and includes broker-dealers that hold Transfer Restricted Securities (i) as a result
of market making activities and other trading activities and (ii) which were acquired directly from the Company or an Affiliate of the Company. 
  
 SECTION 3. SHELF REGISTRATION 
  
 The Company shall within 90 days of the date of original issuance of the Notes, file with the Commission and thereafter shall use its reasonable best
efforts to cause to be declared effective under the Act on or prior to 180 days (plus any additional days allowed as a result of a Supplemental Delay Period) after the date of original issuance of the Notes, a Shelf Registration Statement relating
to the offer and sale of the Transfer Restricted Securities by the Holders from time to time in accordance with the methods of distribution elected by such Holders and set forth in such Shelf Registration Statement. 
  
 The Company shall use its reasonable best efforts to keep the Shelf
Registration Statement continuously effective in order to permit the Prospectus forming part thereof to be usable by Holders for a period of two years from the date of original issuance of the Notes or such shorter period that will terminate when
(i) all the Transfer Restricted Securities covered by the Shelf Registration Statement have been sold pursuant to the Shelf Registration Statement, (ii) the date on which, in the opinion of counsel to the Company, all of the Transfer Restricted
Securities then held by the Holders may be sold by such Holders in the public United States securities markets in the absence of a registration statement covering such sales or (iii) the date on which there ceases to be outstanding any Transfer
Restricted Securities (in any such case, such period being called the “Shelf Registration Period”). The Company shall be deemed not to have used its reasonable best efforts to keep the Shelf Registration Statement effective
during the requisite period if it voluntarily takes any action that would result in Holders of Transfer Restricted Securities covered thereby not being able to offer and sell such securities during that period, unless (i) such action is required by
applicable law, (ii) such action is taken by the Company in good faith and for valid business reasons (not including avoidance of the Company’s obligations hereunder), including the acquisition or divestiture of assets, so long as the Company
promptly thereafter complies with the requirements of Section 4(h) hereof, if applicable or (iii) such action is taken because of any fact or circumstance giving rise to a Supplemental Delay Period. 
  

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 SECTION 4. REGISTRATION PROCEDURES 
  
 In connection with any Shelf Registration Statement, the following provisions shall apply: 
  
 (a) The Company shall ensure that (i) any Shelf Registration Statement and
any amendment thereto and any Prospectus forming part thereof and any amendment or supplement thereto complies in all material respects with the Act and the rules and regulations thereunder, (ii) any Shelf Registration Statement and any amendment
thereto does not, when it becomes effective, contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading and (iii) any Prospectus forming
part of any Shelf Registration Statement, and any amendment or supplement to such Prospectus, does not include an untrue statement of a material fact or omit to state a material fact necessary in order to make the statements, in the light of the
circumstances under which they were made, not misleading. 
  
 (b)
(1) The Company shall advise the Initial Purchasers and the Holders of Transfer Restricted Securities named in any Shelf Registration Statement that have provided in writing to the Company a telephone or facsimile number and address for notices,
and, if requested by the Initial Purchasers or any such Holder, confirm such advice in writing when a Shelf Registration Statement and any amendment thereto has been filed with the Commission and when the Shelf Registration Statement or any
post-effective amendment thereto has become effective. 
  
 (2) The Company shall advise the Initial Purchasers and the Holders of Transfer Restricted Securities named in any Shelf Registration Statement, which have provided in writing to the Company a telephone or facsimile number and address for
notices, and, if requested by the Initial Purchasers or any such Holder, confirm such advice in writing: 
  
 (i)        of any request by the Commission for amendments or supplements to the Shelf
Registration Statement or the Prospectus included therein or for additional information; 
  
 (ii)      of the initiation by the Commission of proceedings relating to a stop order suspending the
effectiveness of the Shelf Registration Statement; 
  
 (iii)    of the issuance by the Commission of any stop order suspending the effectiveness of the Shelf Registration Statement; 
  
 (iv)     of the receipt by the Company of any notification with respect to the suspension of the qualification of
the securities included therein for sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose; and 
  
 (v)      of the existence of any fact and the happening of any event that, in the opinion of the Company,
makes untrue any statement of a material fact made in its Shelf Registration Statement, the Prospectus or any amendment or supplement thereto or any document incorporated by reference therein or requires the making of any changes in the Shelf
Registration Statement or the Prospectus so that, as of such date, the statements therein are not misleading and do not omit to state a material fact required to be stated therein or necessary to make the statements therein (in the case of the
Prospectus, in light of the circumstances under which they were made) not misleading. 
  

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 Such advice may be accompanied by an instruction to suspend the use of the Prospectus until the requisite
changes have been made. 
  
 (c) The Company shall use its best
efforts to obtain the withdrawal of any order suspending the effectiveness of any Shelf Registration Statement at the earliest possible time. 
  
 (d) The Company shall use its best efforts to furnish to each selling Holder named in any Shelf Registration Statement who so requests in writing and who
has provided to the Company an address for notices, without charge, at least one conformed copy of such Shelf Registration Statement and any post-effective amendment thereto, including financial statements and, if the Holder so requests in writing,
all exhibits and schedules (including those incorporated by reference). 
  
 (e) The Company shall, during the Shelf Registration Period, deliver to each Holder of Transfer Restricted Securities named in any Shelf Registration Statement and who has provided to the Company an address for notices, without charge, as
many copies of the Prospectus (including each preliminary Prospectus) contained in such Shelf Registration Statement and any amendment or supplement thereto as such Holder may reasonably request; subject to any notice by the Company in accordance
with Section 5(b) hereof, the Company consents to the use of the Prospectus or any amendment or supplement thereto by each of the selling Holders for the purposes of offering and resale of the Transfer Restricted Securities covered by the Prospectus
in accordance with the applicable regulations promulgated under the Act. 
  
 (f) Prior to any offering of Transfer Restricted Securities pursuant to any Shelf Registration Statement, the Company shall register or qualify or cooperate with the Holders of Transfer Restricted Securities named
therein and their respective counsel in connection with the registration or qualification of such Transfer Restricted Securities for offer and sale under the securities or blue sky laws of such jurisdictions of the United States as any such Holders
reasonably request in writing not later than the date that is five business days prior to the date upon which this Agreement specifies that the Shelf Registration Statement shall become effective; provided, however, that the Company will not
be required to qualify generally to do business in any jurisdiction where it is not then so qualified or to take any action which would subject it to general or unlimited service of process or to taxation in any such jurisdiction where it is not
then so subject. 
  
 (g) The Company shall endeavor to cooperate
with the Holders of Transfer Restricted Securities to facilitate the timely preparation and delivery of certificates representing Transfer Restricted Securities to be sold pursuant to any Shelf Registration Statement free of any restrictive legends
and in such denominations and registered in such names as Holders may request in writing at least two business days prior to sales of securities pursuant to such Shelf Registration Statement. 
  
 (h) Subject to Section 4(l), upon the occurrence of any event contemplated by
Section 4(b)(2)(v) hereof, the Company shall promptly prepare a post-effective amendment to any Shelf Registration Statement or an amendment or supplement to the related Prospectus or file any other required document so that as thereafter delivered
to purchasers of the Transfer Restricted 

  

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Securities covered thereby, the Prospectus will not include an untrue statement of a material fact or omit to state any material fact necessary to make the
statements therein, in the light of the circumstances under which they were made, not misleading; provided that in the event of a material business transaction (including, without limitation, pending negotiations relating to such a
transaction) which would, in the opinion of counsel to the Company, require disclosure by the Company in the Shelf Registration Statement of material non-public information for which the Company has a bona fide business purpose for not disclosing,
then for so long as such circumstances exist, the Company shall not be required to prepare and file a supplement or post-effective amendment hereunder. 
  
 (i) Not later than the effective date of any such Shelf Registration Statement hereunder, the Company shall cause to be provided a CUSIP number for the
Notes registered under such Shelf Registration Statement, and provide the applicable trustee with certificates for such Notes in a form eligible for deposit with The Depository Trust Company. 
  
 (j) During the twelve-month period commencing after effectiveness of the
Shelf Registration Statement, the Company shall make generally available to its security holders in a regular filing on Form 10-Q or 10-K an earnings statement satisfying the provisions of Rule 158 (which need not be audited). 
  
 (k) The Company shall cause the Indenture to be qualified under the Trust
Indenture Act in a timely manner. 
  
 (l) The Company may require
each Holder of Transfer Restricted Securities, which are to be sold pursuant to any Shelf Registration Statement, to furnish to the Company within 20 business days after written request for such information has been made by the Company, such
information regarding the Holder and the distribution of such securities as the Company may from time to time reasonably require for inclusion in such Shelf Registration Statement and such other information as may be necessary or advisable in the
reasonable opinion of the Company and its counsel, in connection with such Shelf Registration Statement. No Holder of Transfer Restricted Securities shall be entitled to the benefit of any Special Interest (as set forth in the Notes) under the
Indenture and the Notes or be entitled to use the Prospectus unless and until such Holder shall have furnished the information required by this Section 4(l) and all such information required to be disclosed in order to make the information
previously furnished to the Company by such Holder not materially misleading. For the purposes of this Section 4(l), upon receipt of information regarding a Holder requiring the filing of a supplement or amendment to the Prospectus, the Company
shall be required to so amend or supplement the Prospectus within five (5) business days from the earlier to occur of: (i) Holders holding at least $5 million in face value of Notes having provided information requiring the filing of such an
amendment or supplement, or (ii) fifteen (15) business days having elapsed from the receipt of such information. 
  
 (m) The Company shall, if requested, promptly incorporate in a Prospectus supplement or post-effective amendment to a Shelf Registration Statement, such
information as the Majority Holders reasonably agree should be included therein in order to effect their distribution of the Notes and shall make all required filings of such Prospectus supplement or post-effective amendment as soon as notified of
the matters to be incorporated in such 

  

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Prospectus supplement or post-effective amendment; provided, however, that the Company shall not be required to take any action pursuant to this
Section 4(m) that would, in the opinion of counsel for the Company, violate applicable law or to include information the disclosure of which at the time would have a material adverse effect on the business or operations of the Company and/or its
subsidiaries, as determined in good faith by the Company. 
  
 (n)
The Company shall enter into such agreements and take all other reasonably appropriate actions in order to expedite or facilitate the registration or the disposition of the Transfer Restricted Securities, and in connection therewith, if an
underwriting agreement is entered into, cause the same to contain indemnification and contribution provisions and procedures no less favorable than those set forth in Section 7 (or such other provisions and procedures acceptable to the Majority
Holders), with respect to all parties to be indemnified pursuant to Section 7. 
  
 (o) The Company shall upon receipt of a reasonable request in writing therefor: 
  
 (i)       make reasonably available at reasonable times prior to the effectiveness of the related Shelf
Registration Statement for inspection by representatives of the Holders of Transfer Restricted Securities to be registered thereunder and any attorney, accountant or other agent retained by such Holders, at the office where normally kept during
normal business hours, all financial and other records, pertinent corporate documents and properties of the Company and its subsidiaries, and cause the Company’s officers, directors and employees to supply all relevant information reasonably
requested by the Holders’ attorneys, accountants or other agents in connection with any such Shelf Registration Statement as is customary for similar due diligence examinations; provided, however, that the foregoing inspection and
information gathering shall be coordinated by one counsel designated by the Holders and that such persons shall first agree in writing with the Company that any information that is designated in writing by the Company, in good faith, as confidential
at the time of delivery of such information shall be kept confidential by such person, unless such disclosure is made in connection with a court proceeding or required by law, or such information becomes available to the public generally or through
a third party without an accompanying obligation of confidentiality; 
  
 (ii)      obtain opinions of counsel to the Company and updates thereof (which counsel and opinions (in form, scope and substance) shall be reasonably satisfactory to the Majority
Holders), addressed to each selling Holder named in the Shelf Registration Statement covering such matters (in form, scope and substance) as those matters set forth in Section 9(e) of the Purchase Agreement; 
  
 (iii)     obtain “cold
comfort” letters (or, in the case of any person that does not satisfy the conditions for receipt of a “cold comfort” letter specified in Statement on Auditing Standards No. 72, an “agreed-upon procedures letter”) and updates
thereof from the independent certified public accountants of the Company (and, if necessary, any other independent certified public accountants of any subsidiary of the Company or of any business acquired by the Company for which financial
statements and financial data are, or are required to be, included in the Shelf Registration Statement), addressed to each selling Holder of Transfer Restricted Securities registered thereunder and the 

  

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underwriters, if any, in customary form and covering matters of the type customarily covered in “cold comfort” letters in connection with primary
underwritten offerings; and 
  
 (iv) deliver such
documents and certificates as may be reasonably requested by the Majority Holders, including those to evidence compliance with Section 4(h). 
  
 The foregoing actions set forth in clauses (ii), (iii) and (iv) of this Section 4(o) shall be performed upon the effectiveness of such
Shelf Registration Statement and the effectiveness of each post-effective amendment thereto. 
  
 (p) The Company may offer securities of the Company other than the Notes under the Shelf Registration Statement, except where such offer would conflict with the terms of the Purchase Agreement. 
  
 SECTION 5. HOLDERS’ AGREEMENTS 
  
 Each Holder of Transfer Restricted Securities severally but not jointly, by
the acquisition of such Transfer Restricted Securities, agrees: 
  
 (a) To furnish the information required to be furnished pursuant to Section 4(l) hereof within the time period set forth therein. 
  
 (b) That upon receipt of a notice of the commencement of a Supplemental Delay Period, it will keep the fact and content of such notice confidential,
forthwith discontinue disposition of its Transfer Restricted Securities pursuant to the Shelf Registration Statement, and will not deliver any Prospectus forming a part thereof until receipt of the amended or supplemented Shelf Registration
Statement or Prospectus, as applicable, as contemplated by Section 4(h) hereof, or until receipt of the Advice. If a Supplemental Delay Period should occur, the Shelf Registration Period shall be extended by the number of days of which the
Supplemental Delay Period is comprised; provided that the Shelf Registration Period shall not be extended if the Company has received an opinion of counsel (which counsel, if different from counsel to the Company referred to in Section 9(e)
of the Purchase Agreement, shall be reasonably satisfactory to the Majority Holders of the Transfer Restricted Securities named in the Shelf Registration Period and which opinion shall be in writing) to the effect that the Transfer Restricted
Securities can be freely tradable without the continued effectiveness of the Shelf Registration Statement. 
  
 (c) If so directed by the Company in a notice of the commencement of a Supplemental Delay Period, each Holder of Transfer Restricted Securities will
deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then in such Holder’s possession, of the Prospectus covering the Transfer Restricted Securities. 
  
 (d) Sales of such Transfer Restricted Securities pursuant to a Shelf
Registration Statement shall only be made in the manner set forth in such currently effective Shelf Registration Statement. 
  

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 SECTION 6. REGISTRATION EXPENSES 
  
 The Company shall bear all expenses incurred in connection with the performance of its obligations under Sections 3 and 4
hereof and will reimburse the Holders for the reasonable fees and disbursements of one firm or counsel designated by the Majority Holders to act as counsel for the Holders in connection with any Shelf Registration Statement. Notwithstanding the
foregoing or anything in this Agreement to the contrary, each Holder shall pay all underwriting discounts and commission of any underwriters with respect to any Transfer Restricted Securities sold by it. 
  
 SECTION 7. INDEMNIFICATION AND CONTRIBUTION 
  
 (a) The Company agrees to indemnify and hold harmless each Holder and each
person, if any, who controls such Holder within the meaning of the Act or the Exchange Act (each Holder, and such controlling persons are referred to collectively as the “Indemnified Parties”) from and against any losses, claims, damages
or liabilities, joint or several, or any actions in respect thereof (including, but not limited to, any losses, claims, damages, liabilities or actions relating to purchases and sales of the Securities) to which each Indemnified Party may become
subject under the Act, the Exchange Act or otherwise, insofar as such losses, claims, damages, liabilities or actions arise out of or are based upon any untrue statement or alleged untrue statement of a material fact contained in the Shelf
Registration Statement or Prospectus including any document incorporated by reference therein, or in any amendment or supplement thereto or in any preliminary prospectus relating to the Shelf Registration, or arise out of, or are based upon, the
omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and shall reimburse, as incurred, the Indemnified Parties for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action in respect thereof; provided, however, that (i) the Company shall not be liable in any such case to the extent
that such loss, claim, damage or liability arises out of or is based upon any untrue statement or alleged untrue statement or omission or alleged omission made in the Shelf Registration Statement or Prospectus or in any amendment or supplement
thereto or in any preliminary prospectus relating to the Shelf Registration in reliance upon and in conformity with written information furnished to the Company by or on behalf of such Holder specifically for inclusion therein and (ii) with respect
to any untrue statement or omission or alleged untrue statement or omission made in any preliminary prospectus relating to the Shelf Registration Statement, the indemnity agreement contained in this subsection (a) shall not inure to the benefit of
any Holder from whom the person asserting any such losses, claims, damages or liabilities purchased the securities concerned, to the extent that a prospectus relating to such securities was required to be delivered by such Holder under the Act in
connection with such purchase and any such loss, claim, damage or liability of such Holder results from the fact that there was not sent or given to such person, at or prior to the written confirmation of the sale of such securities to such person,
a copy of the final Prospectus if the Company had previously furnished copies thereof to such Holder; provided further, however, that this indemnity agreement will be in addition to any liability which the Company may otherwise
have to such Indemnified Party. The Company shall also indemnify underwriters, their officers and directors and each person who controls such underwriters within the meaning of the Act or the Exchange Act to the same extent as provided above with
respect to the indemnification of the Holders if requested by such Holders. 
  

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 (b) Each Holder, severally and not jointly, will indemnify and hold harmless the Company, its officers
and directors and each person, if any, who controls the Company within the meaning of the Act or the Exchange Act from and against any losses, claims, damages or liabilities or any actions in respect thereof, to which the Company or any such
controlling person may become subject under the Act, the Exchange Act or otherwise, insofar as such losses, claims, damages, liabilities or actions arise out of or are based upon any untrue statement or alleged untrue statement of a material fact
contained in the Shelf Registration Statement or Prospectus or in any amendment or supplement thereto or in any preliminary prospectus relating to the Shelf Registration, or arise out of or are based upon the omission or alleged omission to state
therein a material fact necessary to make the statements therein not misleading, but in each case only to the extent that the untrue statement or omission or alleged untrue statement or omission was made in reliance upon and in conformity with
written information furnished to the Company by or on behalf of such Holder specifically for inclusion therein; and, subject to the limitation set forth immediately preceding this clause, shall reimburse, as incurred, the Company for any legal or
other expenses reasonably incurred by the Company or any such controlling person in connection with investigating or defending any loss, claim, damage, liability or action in respect thereof. This indemnity agreement will be in addition to any
liability which such Holder may otherwise have to the Company or any of its controlling persons. 
  
 (c) Promptly after receipt by an indemnified party under this Section 7 of notice of the commencement of any action or proceeding (including a
governmental investigation), such indemnified party will, if a claim in respect thereof is to be made against the indemnifying party under this Section 7, notify the indemnifying party of the commencement thereof; but the omission so to notify the
indemnifying party will not, in any event, relieve the indemnifying party from any obligations to any indemnified party other than the indemnification obligation provided in paragraph (a) or (b) above. In case any such action is brought against any
indemnified party, and it notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled to participate therein and, to the extent that it may wish, jointly with any other indemnifying party similarly notified,
to assume the defense thereof, with counsel reasonably satisfactory to such indemnified party (who shall not, except with the consent of the indemnified party, be counsel to the indemnifying party), and after notice from the indemnifying party to
such indemnified party of its election so to assume the defense thereof the indemnifying party will not be liable to such indemnified party under this Section 7 for any legal or other expenses, other than reasonable costs of investigation,
subsequently incurred by such indemnified party in connection with the defense thereof. No indemnifying party shall, without the prior written consent of the indemnified party, effect any settlement of any pending or threatened action in respect of
which any indemnified party is or could have been a party and indemnity could have been sought hereunder by such indemnified party unless such settlement (i) includes an unconditional release of such indemnified party from all liability on any
claims that are the subject matter of such action, and (ii) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any indemnified party. 
  
 (d) If the indemnification provided for in this Section 7 is unavailable or
insufficient to hold harmless an indemnified party under subsections (a) or (b) above, then each indemnifying party shall contribute to the amount paid or payable by such indemnified party as a result of the losses, claims, damages or liabilities
(or actions in respect thereof) referred to in 

  

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subsection (a) or (b) above in such proportion as is appropriate to reflect the relative fault of the indemnifying party or parties on the one hand and the
indemnified party on the other in connection with the statements or omissions that resulted in such losses, claims, damages or liabilities (or actions in respect thereof) as well as any other relevant equitable considerations. The relative fault of
the parties shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company on the
one hand or such Holder or such other indemnified party, as the case may be, on the other, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The amount paid by
an indemnified party as a result of the losses, claims, damages or liabilities referred to in the first sentence of this subsection (d) shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in
connection with investigating or defending any action or claim which is the subject of this subsection (d). Notwithstanding any other provision of this Section 7(d), the Holders shall not be required to contribute any amount in excess of the amount
by which the net proceeds received by such Holders from the sale of the securities pursuant to the Shelf Registration Statement exceeds the amount of damages which such Holders have otherwise been required to pay by reason of such untrue or alleged
untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act) shall be entitled to contribution from any person who was not guilty of such fraudulent
misrepresentation. For purposes of this paragraph (d), each person, if any, who controls such indemnified party within the meaning of the Act or the Exchange Act shall have the same rights to contribution as such indemnified party and each person,
if any, who controls the Company within the meaning of the Act or the Exchange Act shall have the same rights to contribution as the Company. 
  
 (e) The agreements contained in this Section 7 shall survive the sale of the securities pursuant to the Shelf Registration Statement and shall remain in
full force and effect, regardless of any termination or cancellation of this Agreement or any investigation made by or on behalf of any indemnified party. 
  
 SECTION 8. RULE 144A AND RULE 144 
  
 The Company agrees with each Holder, for so long as any Transfer Restricted Securities remain outstanding and during any period in which the Company (i)
is not subject to Section 13 or 15(d) of the Exchange Act, to make available, upon request of any Holder, to such Holder or beneficial owner of Transfer Restricted Securities in connection with any sale thereof and any prospective purchaser of such
Transfer Restricted Securities designated by such Holder or beneficial owner, the information required by Rule 144A(d)(4) under the Act in order to permit resales of such Transfer Restricted Securities pursuant to Rule 144A, and (ii) is subject to
Section 13 or 15 (d) of the Exchange Act, to make all filings required thereby in a timely manner in order to permit resales of such Transfer Restricted Securities pursuant to Rule 144. 
  
 SECTION 9. MISCELLANEOUS 
  
 (a) No Inconsistent Agreements. The Company has not, as of the date hereof, entered into, nor shall it, on or after the date hereof, enter into,
any agreement with respect to its 

  

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securities that is inconsistent with the rights granted to the Holders herein or otherwise conflicts with the provisions hereof. 
  
 (b) Amendments and Waivers. The provisions of this Agreement,
including the provisions of this sentence, may not be amended, qualified, modified or supplemented, and waivers or consents to departures from the provisions hereof may not be given, unless the Company has obtained the written consent of the Holders
of at least a majority of the then outstanding aggregate principal amount of Notes; provided, however, that with respect to any matter that directly or indirectly affects the rights of any Initial Purchaser hereunder, the Company shall obtain
the written consent of each such Initial Purchaser against which such amendment, qualification, supplement, waiver or consent is to be effective. Notwithstanding the foregoing (except the foregoing proviso), a waiver or consent to depart from the
provisions hereof, with respect to a matter, which relates exclusively to the rights of Holders whose securities are being sold pursuant to a Shelf Registration Statement and does not directly or indirectly affect the rights of other Holders, may be
given by the Majority Holders, determined on the basis of Notes being sold rather than registered under such Shelf Registration Statement. 
  
 (c) Notices. All notices and other communications provided for or permitted hereunder shall be made in writing by hand-delivery, first-class mail,
telex, telecopier, or air courier guaranteeing overnight delivery: 
  
 (i) if to a Holder, at the most current address given by such holder to the Company in accordance with the provisions of this Section 9(c), which address initially is, with respect to each Holder, the address of such
Holder maintained by the registrar under the Indenture; 
  
 (ii) with a copy in like manner to UBS Securities LLC; 
  
 (iii) if to the Initial Purchasers, initially at the respective addresses set forth in the Purchase Agreement; and 
  
 (iv) if to the Company, initially at its address set forth
in the Purchase Agreement. 
  
 All such notices and communications
shall be deemed to have been duly given when received. 
  
 Upon
the date of filing of a Shelf Registration Statement notice shall be delivered to UBS Securities LLC on behalf of the Initial Purchasers (in the form attached hereto as Exhibit A) and shall be addressed to: Attention: Syndicate Department, 299 Park
Avenue, New York, New York 10171. 
  
 The Initial Purchasers or
the Company by notice to the other may designate additional or different addresses for subsequent notices or communications. 
  
 (d) Successors and Assigns. This Agreement shall inure to the benefit of, and be binding upon, the successors and assigns of each of the parties
hereto, including, without the need for an express assignment or any consent by the Company thereto, subsequent Holders of 

  

 12 








 
Notes. The Company hereby agrees to extend the benefits of this Agreement to any Holder of Notes and any such Holder may specifically enforce the provisions
of this Agreement as if an original party hereto. 
  
 (e)
Counterparts. This agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts, each of which when so executed shall be deemed to be an original, and all of which taken together shall constitute
one and the same agreement. 
  
 (f) Headings. The headings
in this agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof. 
  
 (g) Governing Law. This agreement shall be governed by and construed in accordance with the internal laws of the State of New York applicable to
agreements made and to be performed in said State (without reference to the conflict of law rules thereof). 
  
 (h) Severability. In the event that any one or more of the provisions contained herein, or the application thereof in any circumstances, is held
invalid, illegal or unenforceable in any respect for any reason, the validity, legality and enforceability of any such provision in every other respect and the remaining provisions hereof shall not be in any way impaired or affected thereby, it
being intended that all of the rights and privileges of the parties shall be enforceable to the fullest extent permitted by law. 
  
 (i) Notes Held by the Company, etc. Whenever the consent or approval of Holders of a specified percentage of principal amount of Notes is required
hereunder, Notes held by the Company or its Affiliates (other than subsequent Holders of Notes if such subsequent Holders are deemed to be Affiliates solely by reason of their holdings of such Notes) shall not be counted in determining whether such
consent or approval was given by the Holders of such required percentage. 
  
 (j) Entire Agreement. This Agreement is intended by the parties as a final expression of their agreement and intended to be a complete and exclusive statement of the agreement and understanding of the parties
hereto with respect to the subject matter contained herein. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to herein with respect to the registration rights granted with respect to the
Transfer Restricted Securities. This Agreement supersedes all prior agreements and understandings between the parties with respect to such subject matter. 
  
 (k) Waiver of Jury Trial. Each of UBS (on behalf of the Initial Purchasers) and the Company (on its behalf and, to the extent permitted by
applicable law, on behalf of its stockholders and affiliates) waives all right to trial by jury in any action, proceeding or counterclaim (whether based upon contract, tort or otherwise) in any way arising out of or relating to this Agreement.

  

 13 








 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above.

  

			
	INVITROGEN CORPORATION
		
	By:	 	/s/ C. Eric Winzer
	 	 	

	Name:	 	C. Eric Winzer
	Title:	 	Chief Financial Officer


  










			
	 UBS SECURITIES LLC
 BEAR, STEARNS
& CO. INC.

	
	By: UBS SECURITIES LLC
		
	By:	 	 
	 	 	

	 	 	Name:
	 	 	Title:

  

			
		
	By:	 	 
	 	 	

	 	 	Name:
	 	 	Title:

  









 EXHIBIT A 
  

NOTICE OF FILING OF 
 SHELF
REGISTRATION STATEMENT 
  

	To:	UBS Securities LLC 

 299 Park Avenue 
 New York, New York 10171 
 Attention:
[                                ] 
 Fax: (212)         -            

  

	From:	 Invitrogen Corporation 

  1.5% Convertible
Senior Notes due 2024 
  
 Date:
                    , 200   
  
 For your information only (NO ACTION REQUIRED): 
  
 Today,                     , 200  , we filed a
Shelf Registration Statement with the Securities and Exchange Commission. 
  

 4