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                                                                    EXHIBIT 10.3

THESE SECURITIES HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE
COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN
EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
"SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT
TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO
AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE
SECURITIES LAWS.

THIS WARRANT DOES NOT REQUIRE PHYSICAL SURRENDER OF THE WARRANT UPON ANY PARTIAL
EXERCISE HEREOF. AS A RESULT FOLLOWING ANY EXERCISE OF ANY PORTION OF THIS
WARRANT, THE OUTSTANDING NUMBER OF SHARES ISSUABLE UPON EXERCISE OF THIS WARRANT
MAY BE LESS THAN THE AMOUNT OF SHARES SET FORTH BELOW.

               AMENDED AND RESTATED COMMON STOCK PURCHASE WARRANT

                               TO PURCHASE 344,285
                           SHARES OF COMMON STOCK OF

                       CHROMAVISION MEDICAL SYSTEMS, INC.

         This Amended and Restated Common Stock Purchase Warrant (this
"Warrant") will, as of the Effective Time (as defined below) amend and restate
in its entirety the Common Stock Purchase Warrant to purchase 229,523 shares of
Common Stock issued by CHROMAVISION MEDICAL SYSTEMS, INC., a Delaware
corporation (the "COMPANY") to Safeguard Delaware, Inc. on February 10, 2004
(the "ORIGINAL WARRANT"). This Warrant shall not become effective and shall not
be exercisable until immediately prior to consummation of the Initial Closing
(the "Effective Time") of the Securities Purchase Agreement dated March 25, 2004
by and among the Company and the other parties thereto. Until the Effective
Time, the Original Warrant shall remain in full force and effect. Following the
Effective Time, the Original Warrant shall be amended and restated in its
entirety by this Warrant. In the event the Original Warrant is exercised in
whole or in part prior to the Effective Time, such exercise shall be deemed to
have occurred under this Warrant if this Warrant becomes effective.

         SUBJECT TO THE FOREGOING, THIS CERTIFIES that, for value received,
SAFEGUARD DELAWARE, INC., a Delaware corporation, and its successors and assigns
(the "HOLDER") is entitled, upon the terms and subject to the conditions
hereinafter set forth, at any time and from time to time on and after the date
hereof, and on and prior to 8:00 p.m. Eastern Time on March 1, 2008 (the
"EXPIRATION DATE"), but not thereafter, to subscribe for and purchase from the
Company 344,285 shares (the "WARRANT SHARES") of common stock, $0.01 par value
per share of the Company ("COMMON STOCK"). The purchase price of one share of
Common Stock under this Warrant shall be the Exercise Price, as defined below
and as may be adjusted from time to time pursuant to the terms hereof. The
Exercise Price and the number of shares for which this Warrant is exercisable
shall be subject to adjustment as provided herein.

         1.       DEFINITIONS. Capitalized terms used herein and not otherwise
defined shall have the meaning ascribed thereto in the Securities Purchase
Agreement dated February 10, 2004, between the

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Company and Holder. As used in this Warrant, the following terms shall have the
following respective meanings:

         "CHANGE IN CONTROL TRANSACTION" will be deemed to exist if (i) there
occurs any consolidation, merger or other business combination of the Company
with or into any other corporation or other entity or person (whether or not the
Company is the surviving corporation), or any other corporate reorganization or
transaction or series of related transactions in which in any of such events the
voting stockholders of the Company prior to such event cease to own 50% or more
of the voting stock, or corresponding voting equity interests, of the surviving
corporation after such event (including, without limitation, any "GOING PRIVATE"
transaction under Rule 13e-3 promulgated pursuant to the Exchange Act or tender
offer by the Company under Rule 13e-4 promulgated pursuant to the Exchange Act
for 20% or more of the Company's Common Stock), (ii) any person (as defined in
Section 13(d) of the Exchange Act), together with its affiliates and associates
(as such terms are defined in Rule 405 under the Act), other than Safeguard
Scientifics, Inc. or any successor thereto (collectively "SSI") and/or SSI's
affiliates and associates (as such terms are defined in Rule 405 under the Act),
beneficially owns or is deemed to beneficially own (as described in Rule 13d-3
under the Exchange Act without regard to the 60-day exercise period) in excess
of 50% of the Company's voting power, (iii) there is a replacement of more than
one-half of the members of the Company's Board of Directors which is not
approved by those individuals who are members of the Company's Board of
Directors immediately prior to such replacement, (iv) in one or a series of
related transactions, there is a sale or transfer of all or substantially all of
the assets of the Company, determined on a consolidated basis or (v) the Company
enters into an agreement providing for an event set forth in clause (i), (ii),
(iii) or (iv) above, pursuant to which the Common Stock is converted or
reclassified into other securities, cash or property.

         "CONVERTIBLE SECURITIES" means any convertible securities, warrants,
options or other rights to subscribe for or to purchase or exchange for, shares
of Common Stock.

         "EXCHANGE ACT" shall mean the Securities Exchange Act of 1934, as
amended.

         "EXERCISE PRICE" means $2.95, as such figure may be adjusted as
provided herein.

         "PRINCIPAL MARKET" shall mean the market or exchange on which the
Common Stock is then principally traded.

         "SECURITIES ACT" shall mean the Securities Act of 1933, as amended.

         "TRADING DAY" shall mean a day on which there is trading on the
Principal Market.

         "WARRANTS" shall mean this Warrant and any other warrants issued upon
full or partial transfer of this Warrant to any direct or indirect subsequent
transferees of this Warrant.

         2.       TITLE OF WARRANT. The Company shall register this Warrant,
upon records to be maintained by the Company for that purpose, in the name of
the record holder hereof from time to time. The Company may deem and treat the
registered holder as the absolute owner hereof for the purpose of any exercise
hereof or any distribution to the holder, and for all other purposes, and the
Company shall not be affected by notice to the contrary except as provided
herein.

         With the written consent of the Company, such written consent not to be
unreasonably withheld, prior to the expiration hereof and subject to compliance
with applicable laws, this Warrant and all rights hereunder are transferable, in
whole or in part, at the office or agency of the Company by the holder hereof in
person or by duly authorized attorney, upon surrender of this Warrant together
with (a) the

                                       2

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Assignment Form annexed hereto properly endorsed, and (b) any other
documentation reasonably necessary to satisfy the Company that such transfer is
in compliance with all applicable securities laws; provided that no such
transfer may be made to a person that is not an "ACCREDITED INVESTOR" as defined
in Rule 501 of Regulation D of the Securities Act; and provided further that no
consent of the Company is required for any transfer or assignment in whole or in
part from time to time to an affiliate of the Holder or the then holder that is
an "ACCREDITED INVESTOR." The term "HOLDER" as used herein shall refer to the
Holder or any subsequent permitted transferee of this Warrant. If this Warrant
is duly assigned in accordance with the terms hereof, then the Company agrees,
upon the request of the assignee, to amend or supplement promptly any effective
registration statement covering the Warrant Shares so that such assignee is
entitled to be a selling stockholder thereunder.

         3.       AUTHORIZATION OF SHARES. The Company covenants that all shares
of Common Stock which may be issued upon the exercise of rights represented by
this Warrant will, upon exercise of the rights represented by this Warrant and
payment of the Exercise Price as set forth herein, be duly authorized, validly
issued, fully paid and nonassessable and free from all taxes, liens,
encumbrances and charges in respect of the issue thereof (other than taxes in
respect of any transfer occurring contemporaneously with such issue or otherwise
specified herein).

         4.       EXERCISE OF WARRANT.

                  (a)      Exercise Procedure. Exercise of the purchase rights
represented by this Warrant may be made at any time and from time to time, in
whole or in part, on or after the date hereof but before 8:00 p.m. Eastern Time
on the Expiration Date, by delivering the Notice of Exercise annexed hereto duly
completed and executed (which delivery may be by facsimile) to the Company at
the principal office of the Company (or such other office or agency of the
Company as it may designate by notice in writing to the registered holder hereof
at the address of such holder appearing on the books of the Company), and upon
payment of the full Exercise Price of the shares thereby purchased (subject to
subsection (b) below), the holder shall be entitled to receive a certificate for
the number of shares of Common Stock so purchased. Subject to subsection (b)
below, payment of the Exercise Price of the shares shall be by certified check
or cashier's check or by wire transfer to an account designated by the Company
in an aggregate amount equal to the Exercise Price multiplied by the number of
shares being purchased.

                  (b)      Cashless Exercise. Alternatively, and only in the
event the Warrant Shares are not subject to an effective registration statement,
the holder may exercise this Warrant, in whole or in part in a "CASHLESS" or
"NET-ISSUE" exercise by delivering to the offices of the Company or any transfer
agent for the Common Stock a Notice of Exercise specifying the number of Warrant
Shares to be delivered to such holder ("Deliverable Shares") and the number of
Warrant Shares with respect to which this Warrant is being exercised ("EXERCISED
SHARES"). The number of Deliverable Shares shall be calculated as follows:

                                                    (Fair Market Value of Common
# of Deliverable Shares = # of Exercised Shares X   Stock less Exercise Price) /
                                                    Fair Market Value or Common
                                                    Stock

                  "FAIR MARKET VALUE" shall be deemed to be the last reported
sale price of Common Stock on the Trading Day immediately prior to the date of
exercise, or, if not reported, the fair market value of such Common Stock as
reasonably determined by the Company and such holder.

                  (c)      Issuance of Warrant Shares and Unexercised Warrants.
Subject to subsection (d) below, in the event that this Warrant is not exercised
in full, the number of Warrant Shares for which this Warrant may be exercised
shall be reduced by the number of such Warrant Shares for which this Warrant

                                       3

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is exercised and/or surrendered pursuant to this Section 4, and the Company, at
its expense, shall within five (5) Trading Days, issue and deliver to or upon
the order of the holder a new Warrant of like tenor in the name of the holder or
as the holder (upon payment by the holder of any applicable transfer taxes) may
request, reflecting such remaining number of Warrant Shares.

                  All exercises of this Warrant will be deemed to occur as of
the date of receipt by the Company of a validly executed Notice of Exercise (or
such later date as may be indicated on such Notice of Exercise) (such date being
referred to herein as the "EXERCISE DATE"), and certificates for shares of
Common Stock purchased hereunder shall be delivered to the holder hereof within
three (3) Trading Days after the Exercise Date. The holder may withdraw its
Notice of Exercise under Section 3(a) or 3(b) upon written notice to the Company
at any time thereafter, in whole or in part, if the Company fails to timely
deliver the applicable certificates to the holder as provided in this Warrant.

                  In lieu of delivering physical certificates representing the
Warrant Shares issuable upon conversion of this Warrant, provided the Company's
transfer agent is a participant in the Depository Trust Company ("DTC") Fast
Automated Securities Transfer ("FAST") program, upon request of the holder, the
Company shall use its best efforts to cause its transfer agent to electronically
transmit the Warrant Shares issuable upon exercise to the holder, by crediting
the account of the holder's prime broker with DTC through its Deposit Withdrawal
Agent Commission ("DWAC") system. The time periods for delivery described above
shall apply to the electronic transmittals through the DWAC system. The Company
agrees to use its best commercially reasonable efforts to coordinate with DTC to
accomplish this objective.

                  (d)      Book-Entry. Notwithstanding anything to the contrary
set forth herein, upon partial exercise of this Warrant in accordance with the
terms hereof, the holder shall not be required to physically surrender this
Warrant to the Company unless such holder is purchasing the full amount of
Warrant Shares then represented by this Warrant. The holder and the Company
shall maintain records showing the number of Warrant Shares so purchased
hereunder and the dates of such purchases or shall use such other method,
reasonably satisfactory to the holder and the Company, so as not to require
physical surrender of this Warrant upon each such exercise.

         5.       NO FRACTIONAL SHARES OR SCRIP. No fractional Warrant Shares or
scrip representing fractional Warrant Shares shall be issued upon the exercise
of this Warrant. Any fractional share or scrip shall be rounded up to the
nearest whole number.

         6.       CHARGES, TAXES AND EXPENSES. Issuance of certificates for
shares of Common Stock upon the exercise of this Warrant shall be made without
charge to the holder hereof for any issue or transfer tax or other incidental
expense in respect of the issuance of such certificate, all of which taxes and
expenses shall be paid by the Company, and such certificates shall be issued in
the name of the holder or in such name or names as may be directed by the
holder; provided, however, that in the event certificates for shares of Common
Stock are to be issued in a name other than the name of the holder, this Warrant
when surrendered for exercise shall he accompanied by the Assignment Form
attached hereto duly executed by the holder hereof, and provided further, that
the Company shall not be required to pay any tax or taxes or any other fees or
expenses applicable to the holder or its transferee which may be payable in
respect of any transfer involved in the issuance of any Warrant certificates or
any certificates for the Warrant Shares in a name other than the name of the
holder.

         7.       CLOSING OF BOOKS. The Company will at no time close its
stockholder books or records in any manner which interferes with the timely
exercise of this Warrant.

                                       4

<PAGE>

         8.       NO RIGHTS AS SHAREHOLDER UNTIL EXERCISE. Subject to Sections
12 and 13 of this Warrant and the provisions of any other written agreement
between the Company and the holder, prior to the exercise of this Warrant as
provided herein, the holder shall not be entitled to vote or receive dividends
or be deemed the holder of Warrant Shares or any other securities of the Company
that may at any time be issuable on the exercise hereof for any purpose, nor
shall anything contained herein be construed to confer upon the holder, as such,
any of the rights of a stockholder of the Company or any right to vote for the
election of directors or upon any matter submitted to stockholders at any
meeting thereof, or to give or withhold consent to any corporate action (whether
upon any recapitalization, issuance of stock, reclassification of stock, change
of par value, or change of stock to no par value, consolidation, merger,
conveyance or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights. However, at the time of the exercise of this
Warrant pursuant to Section 4 hereof, the Warrant Shares so purchased hereunder
shall be deemed to be issued to such holder as the record owner of such shares
as of the close of business on the date on which this Warrant shall have been
exercised.

         9.       REMEDIES. If the Company shall fail to deliver to the holder
the Warrant Shares to be issued to the holder hereunder by the third Trading Day
following the Exercise Date, whether by physical delivery of certificates or by
book-entry transfer through DTC for such Warrant Shares, the Company shall, in
addition to any other remedies under this Warrant or at law or in equity, pay as
additional damages in cash to the holder, by the seventh (7th) Trading Day
following the Exercise Date, an amount equal to one percent (1%) of the value of
the Warrant Shares, and on each succeeding fifth (5th) Trading Day thereafter
until such Warrant Shares are delivered, an amount equal to two percent (2%), of
the value of the Warrant Shares not delivered to the holder by such third (3rd)
Trading Day following the Exercise Date, based on the Fair Market Value as of
the Exercise Date. The Company acknowledges that this remedy is partial and
non-exclusive.

         10.      LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT;
DENOMINATION. In the event that any holder notifies the Company that its
Warrant(s) have been lost, stolen or destroyed, then replacement Warrant(s)
identical in all respects to the original Warrant(s) (except for any
registration number and any adjustments to the Exercise Price or the number of
Warrant Shares issuable hereunder pursuant hereto, if different than that shown
on the original Warrant(s)) shall be delivered to the holder by the Company
within three (3) Trading Days; provided that such holder executes and delivers
to the Company an agreement reasonably satisfactory to the Company to indemnify
the Company from any loss incurred by it in connection with such Warrants. This
Warrant is exchangeable for an equal aggregate number of Warrants of different
denominations, as requested by the holder surrendering the same. No service
charge will be made for such registration, replacement, transfer or exchange.

         11.      SATURDAYS, SUNDAYS, HOLIDAYS, ETC. If the last or appointed
day for the taking of any action or the expiration of any right required or
granted herein shall be a Saturday, Sunday or a legal holiday, then such action
may be taken or such right may be exercised on the next succeeding day not a
legal holiday.

         12.      EFFECT OF CERTAIN EVENTS. If at any time while this Warrant or
any portion hereof is outstanding and unexpired there shall be a Change in
Control Transaction, then the holder shall have the right thereafter to
purchase, by exercise of this Warrant and payment of the aggregate Exercise
Price in effect immediately prior to such Change in Control Transaction, the
kind and amount of consideration including cash, stock, other securities, assets
or any other property, which it would have owned or have been entitled to
receive upon or after the happening of such transaction had this Warrant been
exercised immediately prior thereto, subject to further adjustment as provided
in Section 13. The Company shall not consummate a Change in Control Transaction
unless the entity resulting from such transaction (if not the Company), or such
transferee entity, as the case may be, shall expressly assume, by supplemental
agreement reasonably satisfactory in form and substance to the holder, the due
and punctual performance

                                       5

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and observance of each and every covenant and condition of this Warrant to be
performed and observed by the Company.

         13.      ADJUSTMENTS OF EXERCISE PRICE AND NUMBER OF WARRANT SHARES.
For purposes of any adjustment of the Exercise Price pursuant to this Section
13, the "EXERCISE PRICE" shall be deemed to be the Exercise Price as may have
been previously adjusted hereunder.

                  (a)      Stock Dividends, Splits, Combinations and
Reclassifications. If, to the extent not covered by Section 12 above, the
Company or any Subsidiary, at any time while this Warrant or any portion thereof
is issued, outstanding and unexpired: (A) shall declare or pay a stock dividend
or otherwise make a distribution or distributions on any equity securities
(including securities convertible into or exchangeable or exercisable for such
equity securities) in shares of Common Stock; (B) subdivide the then outstanding
Common Stock into a larger number of shares; (C) combine the then outstanding
Common Stock into a smaller number of shares or (D) issue any shares of its
capital stock in a reclassification of the Common Stock (including, without
limitation, in connection with any merger or consolidation), then the Exercise
Price then in effect hereunder shall be adjusted by multiplying the Exercise
Price by a fraction, the numerator of which shall be the number of shares of
Common Stock (excluding treasury shares, if any) outstanding before such event
and the denominator of which shall be the number of shares of Common Stock
(excluding treasury shares, if any) outstanding after such event. Any adjustment
made pursuant to this Section 13(a) shall become effective immediately after the
record date for the determination of stockholders entitled to receive such
dividend or distribution and shall become effective immediately after the
effective date in the case of a subdivision or combination.

                  (b)      Distributions. If the Company or any Subsidiary, at
any time while this Warrant is outstanding, shall distribute to all holders of
Common Stock evidences of its indebtedness or assets or cash or rights or
warrants to subscribe for or purchase any security of the Company or any of its
subsidiaries, then the Exercise Price in effect at the opening of business on
the day following the date fixed for the determination of holders of Common
Stock entitled to receive such distribution shall be adjusted by multiplying
such Exercise Price by a fraction, the numerator of which shall be the Fair
Market Price (as defined below) per share of the Common Stock less the then fair
market value as reasonably determined by the Board of Directors of the portion
of the evidences of indebtedness or assets or rights or warrants so distributed
(and for which an adjustment to the Exercise Price has not previously been made
pursuant to the terms of this Section 13) applicable to one share of Common
Stock, and the denominator of which shall be such Fair Market Price per share of
the Common Stock, such adjustment to become effective immediately after the
opening of business on the day following the date fixed for the determination of
holders of Common Stock entitled to receive such distribution. "FAIR MARKET
PRICE" shall mean the closing market price per share of Common Stock on the
Principal Market on the Trading Day next preceding such fixed determination date
or such other date on which the Fair Market Price is being determined. The
Company shall deliver to each holder a notice setting forth the Exercise Price
after such adjustment and setting forth a brief statement of the facts requiring
such adjustment and the computation thereof. In the event that the Exercise
Price shall change by more than 5%, the holder shall have the right to have the
fair market value determined by an independent nationally reputable investment
banker mutually selected by the Company and the holder, at the Company's
expense.

                  For the purposes of the foregoing adjustments, in the case of
the issuance of any Convertible Securities, the maximum number of shares of
Common Stock issuable upon exercise, exchange or conversion of such Convertible
Securities shall be deemed to be outstanding, provided that no further
adjustment shall be made upon the actual issuance of Common Stock upon exercise,
exchange or conversion of such Convertible Securities.

                                       6

<PAGE>

                  (c)      Inverse Proportional Adjustments to Exercise Price
and Warrant Shares. In the event of any adjustment in the number of Warrant
Shares issuable hereunder upon exercise pursuant to Section 13(a) or 13(b)
hereof, the Exercise Price shall be inversely proportionately increased or
decreased, as the case may be, such that aggregate purchase price for Warrant
Shares upon full exercise of this Warrant shall remain the same. Similarly, in
the event of any adjustment in the Exercise Price pursuant to Section 13(a) or
13(b) hereof, the number of Warrant Shares issuable hereunder upon exercise
shall be inversely proportionately increased or decreased as the case may be,
such that aggregate purchase price for Warrant Shares upon full exercise of this
Warrant shall remain the same.

         14.      NOTICES. If:

                  (i)      the Company shall declare a dividend (or any other
         distribution) on its Common Stock; or

                  (ii)     the Company shall declare a special nonrecurring cash
         dividend on or a redemption of its Common Stock; or

                  (iii)    the Company shall authorize the granting to all
         holders of the Common Stock rights or warrants to subscribe for or
         purchase any shares of capital stock of any class or of any rights; or

                  (iv)     the approval of any stockholders of the Company shall
         be required in connection with any reclassification of the Common Stock
         of the Company, any consolidation or merger to which the Company is a
         party, any sale or transfer of all or substantially all of the assets
         of the Company, or any compulsory share exchange whereby the Common
         Stock is converted into other securities, cash or property; or

                  (v)      the Company shall authorize the voluntary
         dissolution, liquidation or winding up of the affairs of the Company;

then the Company shall cause to be facsimiled and mailed to each holder at their
last addresses as they shall appear upon the Warrant register of the Company, at
least 20 business days prior to the applicable record or effective date
hereinafter specified, a notice stating (x) the date on which a record is to be
taken for the purpose of such dividend, distribution, redemption, rights or
warrants, or if a record is not to be taken, the date fixed to determine which
holders of Common Stock of record will be entitled to such dividend,
distributions, redemption, rights or warrants and/or (y) the date on which such
reclassification, consolidation, merger, sale, transfer or share exchange is
expected to become effective or close, and the date as of which it is expected
that holders of Common Stock of record shall be entitled to exchange their
shares of Common Stock for securities, cash or other property deliverable upon
such reclassification, consolidation, merger, sale, transfer, share exchange,
dissolution, liquidation or winding up.

         15.      INTENTIONALLY DELETED.

         16.      NOTICE OF ADJUSTMENT. Whenever the number of Warrant Shares or
number or kind of securities or other property purchasable upon the exercise of
this Warrant or the Exercise Price is adjusted, the Company shall promptly
facsimile and mail by registered or certified mail, return receipt requested, to
the registered holder a notice setting forth the number of Warrant Shares (and
other securities or property) purchasable upon the exercise of this Warrant and
the Exercise Price of such Warrant Shares after giving effect to such
adjustment, setting forth a brief statement of the facts requiring such
adjustment and setting forth the computation by which such adjustment was made.

                                       7

<PAGE>

         17.      AUTHORIZED SHARES.  The Company covenants that during the
period this Warrant is outstanding and exercisable, it will reserve from its
authorized and unissued Common Stock a sufficient number of shares to provide
for the issuance of the Warrant Shares upon the exercise of any and all purchase
rights under this Warrant. The Company further covenants that its issuance of
this Warrant shall constitute full authority to its officers who are charged
with the duty of executing stock certificates to execute and issue the necessary
certificates for the Warrant Shares upon the exercise of the purchase rights
under this Warrant. The Company will take all such reasonable action as is
necessary and within its control to assure that such Warrant Shares may be
issued as provided herein without violation of any applicable law or regulation,
or of any requirements of the Principal Market or any other domestic securities
exchange or market upon which the Common Stock may be listed.

         18.      MISCELLANEOUS.

                  (a)      Issue Date; Choice of Law; Venue; Jurisdiction; No
Jury Trial. THE PROVISIONS OF THIS WARRANT SHALL BE CONSTRUED AND SHALL BE GIVEN
EFFECT IN ALL RESPECTS AS IF IT HAD BEEN ISSUED AND DELIVERED BY THE COMPANY ON
THE DATE HEREOF. THIS WARRANT SHALL BE BINDING UPON ANY SUCCESSORS OR PERMITTED
ASSIGNS OF THE COMPANY. THIS WARRANT WILL BE CONSTRUED AND ENFORCED IN
ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF DELAWARE, EXCEPT FOR
MATTERS ARISING UNDER THE SECURITIES ACT, WITHOUT REFERENCE TO PRINCIPLES OF
CONFLICTS OF LAW. EACH OF THE PARTIES CONSENTS TO THE EXCLUSIVE JURISDICTION OF
THE STATE AND FEDERAL COURTS SITTING IN THE COUNTY OF DELAWARE IN THE STATE OF
DELAWARE IN CONNECTION WITH ANY DISPUTE ARISING UNDER THIS WARRANT AND HEREBY
WAIVES, TO THE MAXIMUM EXTENT PERMITTED BY LAW, ANY OBJECTION, INCLUDING,
WITHOUT LIMITATION, ANY OBJECTION BASED ON FORUM NON CONVENIENS. TO THE BRINGING
OF ANY SUCH PROCEEDING IN SUCH JURISDICTION. EACH PARTY HEREBY AGREES THAT IF
THE OTHER PARTY TO THIS WARRANT OBTAINS A JUDGMENT AGAINST IT IN SUCH A
PROCEEDING, THE PARTY WHICH OBTAINED SUCH JUDGMENT MAY ENFORCE SAME BY SUMMARY
JUDGMENT IN THE COURTS OF ANY COUNTRY HAVING JURISDICTION OVER THE PARTY AGAINST
WHOM SUCH JUDGMENT WAS OBTAINED, AND EACH PARTY HEREBY WAIVES ANY DEFENSES
AVAILABLE TO IT UNDER LOCAL LAW AND AGREES TO THE ENFORCEMENT OF SUCH A
JUDGMENT. EACH PARTY TO THIS WARRANT IRREVOCABLY CONSENTS TO THE SERVICE OF
PROCESS IN ANY SUCH PROCEEDING BY THE MAILING OF COPIES THEREOF BY REGISTERED OR
CERTIFIED MAIL, POSTAGE PREPAID, TO SUCH PARTY AT ITS ADDRESS IN ACCORDANCE WITH
SECTION 18(C). NOTHING HEREIN SHALL AFFECT THE RIGHT OF ANY PARTY TO SERVE
PROCESS IN ANY OTHER MANNER PERMITTED BY LAW. EACH PARTY WAIVES ITS RIGHT TO A
TRIAL BY JURY

                  (b)      Modification and Waiver. This Warrant and any
provisions hereof may be changed, waived, discharged or terminated only with the
written approval of (i) the holder hereof and the Company or (ii) the Majority
Holders and the Company. "MAJORITY HOLDERS" means holders of a majority of the
Warrants (with such majority being determined based on the number of warrant
shares underlying such Warrants). Any amendment effected in accordance with
clause (i) of the preceding sentence shall be binding upon the Holder, each
future holder and the Company, and any amendment effected in accordance with
clause (ii) shall be binding upon all holders of Warrants (including the Holder)
and the Company. No waivers of, or exceptions to, any term, condition or
provision of this Warrant, in any one or more instances, shall be deemed to be,
or construed as, a further or continuing waiver of any such term, condition or
provision at any other time.

                                       8

<PAGE>

                  (c)      Notices. Any notice, request or other document
required or permitted to be given or delivered to the Holder or future holders
hereof or the Company shall be personally delivered or facsimiled or shall be
sent by reputable overnight courier or certified or registered mail, postage
prepaid, to the Holder or each such holder at its address as shown on the books
of the Company or to the Company at the address set forth in the Purchase
Agreement. All notices under this Warrant shall be deemed to have been given (i)
in the case of personal or facsimile delivery, on the date of such delivery,
(ii) in the case of mailing, when received and (iii) in the case of overnight
courier, upon receipt. A party may from time to time change the address to which
notices to it are to be delivered or mailed hereunder by notice delivered in
accordance with the provisions of this Section 18(c).

                  (d)      Severability. Whenever possible, each provision of
this Warrant shall be interpreted in such manner as to be effective and valid
under applicable law, but if any provision of this Warrant is held to be
invalid, illegal or unenforceable in any respect under any applicable law or
rule in any jurisdiction, such invalidity, illegality or unenforceability shall
not affect the validity, legality or enforceability of any other provision of
this Warrant in such jurisdiction or affect the validity, legality or
enforceability of any provision in any other jurisdiction, but this Warrant
shall be reformed, construed and enforced in such jurisdiction as if such
invalid, illegal or unenforceable provision had never been contained herein.

                  (e)      No Impairment. The Company shall not, by amendment of
its Certificate of Incorporation or through any reorganization, transfer of
assets, consolidation, merger, dissolution, issuance or sale of securities or
any other voluntary action, avoid or seek to avoid the observance or performance
of any of the terms of this Warrant, but shall at all times in good faith assist
in the carrying out of all such terms and in the taking of all such action as
may be necessary or appropriate in order to protect the rights of the holder
granted hereunder against impairment. Without limiting the generality of the
foregoing, the Company (a) shall not increase the par value of any Warrant
Shares above the amount payable therefor on such exercise and (b) shall take all
such action as may be reasonably necessary or appropriate in order that the
Company may validly and legally issue fully paid and nonassessable Warrant
Shares on the exercise of this Warrant.

                  (f)      Specific Performance. The Company acknowledges and
agrees that irreparable damage would occur in the event that the Company fails
to perform any of the provisions of this Warrant in accordance with its specific
terms. It is accordingly agreed that the holder shall be entitled to seek an
injunction or injunctions to prevent or cure breaches of the provisions of this
Warrant and to enforce specifically the terms and provisions hereof this being
in addition to any other remedy to which the holder may be entitled at law or in
equity.

                                       9

<PAGE>

         IN WITNESS WHEREOF, the Company has caused this Warrant to be duly
executed by its duly authorized officer.

Dated: March 25, 2004

                                           CHROMAVISION MEDICAL SYSTEMS, INC.

                                           By:__________________________________
                                           Name:
                                           Title:

ACCEPTED AND AGREED

SAFEGUARD DELAWARE, INC.

By:_______________________________________
Name:
Title:

                                       10

<PAGE>

                               NOTICE OF EXERCISE

             (To be executed by the holder to exercise the right to
          purchase shares of Common Stock under the foregoing Warrant)

TO:     CHROMAVISION MEDICAL SYSTEMS, INC.

RE:     COMMON STOCK PURCHASE WARRANT issued to ______________________________
        on February _, 2004 to purchase shares of Common Stock (the "Warrant")

(1)     CHECK ONE:

____    (a)     The undersigned hereby elects to purchase_____________________
        shares of Common Stock of CHROMAVISION MEDICAL SYSTEMS, INC. pursuant to
        Section 4(a) of the Warrant, and will tender payment of the purchase
        price in full, together with all applicable transfer taxes payable
        pursuant to the Warrant, if any.

                                       OR

____    (b) The undersigned hereby exercises the Warrant with respect __________
        shares of Common Stock of CHROMAVISION MEDICAL SYSTEMS, INC. on a
        cashless, "net basis" pursuant to Section 4(b) of the Warrant, and
        hereby instructs the Company to deliver ________________________________
        shares of Common Stock to the holder of the Warrant based on a Fair
        Market Value of $ ________.

 (2)    Please issue a certificate or certificates representing said shares of
        Common Stock in the name of the undersigned or in such other name as is
        specified below:

                ________________________________
                Name

                ________________________________
                Address

(3)     Please issue a new Warrant for the unexercised portion of the attached
        Warrant in the name of the undersigned or in such other name as is
        specified below:

                ________________________________
                Name

                ________________________________
                Address

Dated:__________________________             Print Name of Holder:

                                             ___________________________________
                                             (Sign) By: ________________________
                                             Print Name:
                                             Print Title:

<PAGE>

                                 ASSIGNMENT FORM

               (To assign the foregoing Warrant, execute this form
              and supply the required information. Do not use this
                         form to exercise the Warrant.)

        FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers
unto __________________________________the right represented by the within
Warrant to purchase_____________ shares of Common Stock of CHROMAV1SION MEDICAL
SYSTEMS, INC. to which the within Warrant relates and
appoints________________________ attorney to transfer said right on the books of
CHROMAVISION MEDICAL SYSTEMS, INC. with full power of substitution in the
premises.

Dated:

__________________________________

                                               _________________________________
                                               (Signature must conform in all
                                               respects to name of holder as
                                               specified on the face of the
                                               Warrant)

                                               _________________________________
                                               Address of Transferee

                                               _________________________________

                                               _________________________________

In the presence of:

__________________________________