EX-10.19



 Exhibit 10.19 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE EXAGEN INC. HAS DETERMINED THE
INFORMATION (I) IS NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO EXAGEN INC. IF PUBLICLY DISCLOSED. 
 SECOND AMENDMENT TO
AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT 
 This SECOND AMENDMENT TO AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT (this
“Second Amendment”) is made as of the 30th day of September, 2013, by and between the University of Pittsburgh – Of the Commonwealth System of Higher Education, a non-profit corporation organized and existing under
the laws of the Commonwealth of Pennsylvania (“University”) and Exagen Diagnostics, Inc., a corporation existing under the laws of Delaware (“Licensee”). 

WHEREAS, University and Licensee have previously entered into an Amended and Restated Exclusive License Agreement dated as of August 2,
2011 (the “Agreement”) and a First Amendment to Amended and Restated Exclusive License dated as of May 17, 2012 (the “First Amendment”); and 

WHEREAS, the parties wish to amend the Agreement as set forth herein. 

NOW, THEREFORE, in consideration of the foregoing and for good and valuable consideration, the receipt and sufficiency which are hereby
acknowledged, the parties hereby agree as follows: 
  

	1.	 In consideration of the rights, privileges and license granted by the University hereunder, Licensee shall pay
a fee in connection with this Second Amendment in the amount of [***] which shall be non-refundable and non-creditable against royalties or any other payments, and which shall be due immediately upon execution of this Second Amendment.



  

	2.	 Amendments. 


  

	 	(a)	 Article 1.7 of the Agreement is hereby deleted and replaced in its entirety as follows: 



“1.7 “PATENT RIGHTS” shall mean UNIVERSITY intellectual property described below and assigned to the UNIVERSITY: 

 

	 	(a)	 The United States patents and/or patent applications listed in Exhibit A; 



 

	 	(b)	 United States patents issued from the applications listed in Exhibit A and from divisionals and continuations
and continuations in part of these applications; and 


  

	 	(c)	 Claims of U.S. continuation in part and divisional applications, and of the resulting patents, which are
directed to subject matter specifically described in the U.S. applications listed in Exhibit A.” 


  

	 	(b)	 A new Article 1.11 is added to the Agreement: 



  

	***	 Certain Confidential Information Omitted 




  
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 “1.11 “MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD”
shall mean any and all applications of the Patent Rights in Monitoring of Organ Transplantation & Organ Rejection.” 
  

	 	(c)	 Article 1.4(b) is hereby deleted and replaced in its entirety as follows: 



“1.4(b) Manufactured by using a process or is employed to practice a process which is covered in whole or in part by an issued, unexpired
claim or a pending claim contained in the PATENT RIGHTS in the country in which any such process in the SLE FIELD or the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD is used or in which such product or part thereof or service
is used or sold.” 
  

	 	(d)	 Article 2.1 is hereby deleted and replaced in its entirety as follows: 



“2.1 Subject to the terms and conditions of this Agreement, University hereby grants to LICENSEE, to the extent it may lawfully do so,
the right and exclusive license in the TERRITORY to make, have made, use, offer for sale, import and sell the LICENSED TECHNOLOGY in the SLE FIELD and the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD and to practice under the
PATENT RIGHTS in the SLE FIELD and the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD to the end of the term for which the PATENT RIGHTS are granted, unless this Agreement is terminated as provided herein. UNIVERSITY reserves
the royalty-free, nonexclusive right to practice under the PATENT RIGHTS for NON-COMMERCIAL EDUCATION AND RESEARCH PURPOSES and to use the LICENSED TECHNOLOGY for
NON-COMMERCIAL EDUCATION AND RESEARCH PURPOSES.” 
  

	 	(e)	 A new Article 3.4 is added to the Agreement: 



“3.4. In addition, LICENSEE shall adhere to the following milestone in the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION
FIELD: Within sixty (60) months from the Effective Date of this Agreement, begin a clinical trial for monitoring of organ transplantation and/or organ rejection claims.” 

 

	 	(f)	 A new Article 3.5 is added to the Agreement: 



“LICENSEE’s failure to fulfill on a timely basis the milestone set forth in Section 3.4 hereof shall be grounds for UNIVERSITY
to terminate this Agreement pursuant to Section 10.2(a); except that for a single time, if the milestone in Section 3.4 has not been completed within the time frame 

  
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allotted through no fault of LICENSEE and following the best efforts of LICENSEE to meet such milestone, LICENSEE may, on a one-time basis, notify the UNIVERSITY in writing that it desires a
single six (6) month extension to meet such milestone and LICENSEE shall be deemed to have fulfilled the milestone requirement if LICENSEE makes a penalty payment of [***] dollars ($[***]) with both notice and penalty payment to be received by
the UNIVERSITY within ten days of the applicable milestone achievement date. In such case the LICENSEE and UNIVERSITY shall negotiate a new time for attainment of such missed milestone (not to exceed six months) and subsequent timeframes relying
upon the meeting of previous milestones may also be adjusted. Failure by LICENSEE to make the penalty payment or failure to achieve the milestone by the revised milestone date shall result in the FIELD of this Agreement to be automatically amended
to remove the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD, and University shall be free to license the removed indication either exclusively or non-exclusively to any third party
regardless of whether LICENSEE and UNIVERSITY execute a confirmatory Amendment to this Agreement to this effect. For the avoidance of doubt, in the event the previous sentence is triggered, LICENSEE’S exclusive rights in the SLE FIELD shall not
be affected. 
  

	 	(g)	 Article 4.2 is hereby deleted and replaced in its entirety as follows: 



“4.2. In the event that it should prove necessary for LICENSEE to license intellectual property rights owned by a third party in order to
practice the LICENSED TECHNOLOGY in the SLE FIELD or the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD in order to avoid infringing the patent or other intellectual property rights of such third party, then LICENSEE shall be
entitled to a credit of such third party royalties against royalties due to UNIVERSITY under Section 4.1(b), and Section 4.1(c), provided that (i) in no event shall the royalty rate applicable to NET SALES in the SLE FIELD or the
MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD be less than [***] percent ([***]%) and (ii) in no event shall the royalty rate applicable to NET SALES in the SLE FIELD or the MONITORING OF ORGAN TRANSPLANTATION &
ORGAN REJECTION FIELD from a sub-Licensee be less than [***] percent ([***]%).” 
  

	 	(h)	 Article 6.3 is hereby deleted and replaced in its entirety as follows: 



“6.3. LICENSEE shall own any new patent application, and any patent that issues therefrom, or new technology in the SLE FIELD or the
MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD developed independently of the UNIVERSITY and UNIVERSITY employees and shall not owe the UNIVERSITY any fee or 

  

	***	 Certain Confidential Information Omitted 




  
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royalty under section 4 relating to such a new patent application, and any patent that issues therefrom, or new technology.” 

 

	 	(i)	 Article 7.2 is hereby deleted and replaced in its entirety as follows: 



“During the term of this Agreement, LICENSEE shall have the right, but shall not be obligated, to prosecute at its own expense all
infringements of the PATENT RIGHTS in the SLE FIELD or the MONITORING OF ORGAN TRANSPLANTATION & ORGAN REJECTION FIELD if LICENSEE has notified UNIVERSITY in writing of its intent to prosecute. In furtherance of such right, UNIVERSITY
hereby agrees that LICENSEE may include UNIVERSITY as a party plaintiff in any such suit, without expense to UNIVERSITY. [***]” 
  

	 	(j)	 Exhibit A of the Agreement is deleted and replaced with the attached Exhibit A. 



 

	 	(k)	 Exhibit B of the Agreement is hereby deleted. 



 

	2.	 Miscellaneous. 



 

	 	(a)	 Except as specifically amended above, all terms of the Agreement, as amended by the First Amendment, shall
remain in full force and effect. To the extent that there are any inconsistencies between the terms of the Agreement, the First Amendment, and/or the terms of this Second Amendment, the terms of this Second Amendment shall prevail in effect.



  

	 	(b)	 The parties acknowledge that this Second Amendment and the Agreement, as previously amended, set forth the
entire understanding and intentions of the parties hereto as to the subject matter hereof and supersedes all previous understandings between the parties, written or oral, regarding such subject matter. 



[Remainder of this page is left intentionally blank.] 

  

	***	 Certain Confidential Information Omitted 




  
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 IN WITNESS WHEREOF, the parties have executed this Second Amendment as of the date first written
above. 
  

					
	UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
		
	By	 	 /s/ Jerome Cochran

		 	Name:	 	Jerome Cochran
		 	Title:	 	Executive Vice Chancellor
	
	LICENSEE
		
	By	 	 /s/ Ron Rocca

	Name:	 	Ron Rocca
	Title:	 	Chief Executive Officer



  
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 EXHIBIT A 

PATENT RIGHTS FOR SECOND AMENDMENT TO AMENDED AND RESTATED EXCLUSIVE LICENSE AGREEMENT BETWEEN THE UNIVERSITY OF PITTSBURGH AND EXAGEN
DIAGNOSTICS 
  

													
	 Univ.
Case
No.
	  	 Application No.
	  	 Application

Filing
 Date
	  	 Patent No.
	  	 Patent

Issuance
 Date
	  	 Title
	  	 Country

	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]


  

	***	 Certain Confidential Information Omitted 




  
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	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]


  

	***	 Certain Confidential Information Omitted 




  
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