Exhibit 10.8


 


EXECUTION VERSION

CONFIDENTIAL


 


AMENDED AND RESTATED LICENSE AGREEMENT


 


by and among


 


SpringWorks Subsidiary 2, Inc.,


 


Pfizer Inc.,


 


Pfizer Products Inc.


 


and, solely for purposes of Article
11 and Sections 3.2 and 3.3 hereof,


 


SpringWorks Therapeutics, Inc.,


 


as of July 31, 2019


 




     


     


    

 


TABLE OF CONTENTS


 


	1.	Definitions.	1
	 	1.1	Definitions.	1
	 	1.2	Interpretation.	14
	2.	License Grant.	15
	 	2.1	License Grants.	15
	 	2.2	Sublicense Rights.	15
	 	2.3	Retained Rights.	16
	 	2.4	Residuals.	16
	 	2.5	No Additional Rights.	17
	 	2.6	Right of First Negotiation.	17
	 	2.7	365(n) Rights.	18
	 	2.8	Exclusivity.	19
	3.	Transfer Activities.	19
	 	3.1	Transfer Activities Schedules.	19
	 	3.2	Compassionate Use and IIRs.	19
	 	3.3	Transition and Assignment Agreements.	20
	 	3.4	Terminated Agreements and MTAs.	20
	4.	Development; Commercialization; Manufacturing.	20
	 	4.1	General.	20
	 	4.2	Diligence.	20
	 	4.3	Regulatory Filings.	21
	 	4.4	Progress Reporting.	21
	 	4.5	CROs and CMOs.	21
	 	4.6	Development Plan.	21
	 	4.7	Pharmacovigilance Agreement.	22
	 	4.8	Joint Development Committee.	22
	5.	Payment Terms.	23
	 	5.1	Transfer Activities Payments.	23
	 	5.2	Development Milestone Payments.	23
	 	5.3	Sales Milestone Payments.	24
	 	5.4	Royalty Payments.	25
	 	5.5	Royalty Deductions.	26
	 	5.6	Transaction Completion Payment.	27
	 	5.7	Other Payments.	27
	 	5.8	Late Payments.	27
	 	5.9	Currency.	28
	 	5.10	Method of Payment.	28
	 	5.11	Taxes.	28
	 	5.12	Royalty Reconciliation.	29
	6.	Records; Audit Rights.	29
	 	6.1	Relevant Records.	29
	 	6.2	Audit Request.	30
	 	6.3	Audit Fees and Expenses.	30
	 	6.4	Payment of Deficiency.	30
	7.	Intellectual Property Rights.	30


 




     


     


    

 


	 	7.1	Pre-existing IP.	30
	 	7.2	Developed IP.	30
	 	7.3	Inactive Patents.	31
	 	7.4	Patent Prosecution of Licensed Patent Rights.	31
	 	7.5	Listing in Orange Book.	32
	8.	Infringement; Misappropriation.	32
	 	8.1	Notification.	32
	 	8.2	Infringement Action.	33
	9.	Confidentiality.	34
	 	9.1	Definition.	34
	 	9.2	Obligations.	34
	 	9.3	Exceptions.	34
	 	9.4	Right to Injunctive Relief.	35
	 	9.5	Ongoing Obligation for Confidentiality.	35
	10.	Representations, Warranties and Covenants.	35
	 	10.1	Representations and Warranties by Each Party.	35
	 	10.2	Representations and Warranties by Pfizer.	36
	 	10.3	Representations, Warranties and Covenants by Licensee.	38
	 	10.4	Representations, Warranties and Covenants related to Compliance Laws.	38
	 	10.5	No Action Required Which Would Violate Law.	39
	 	10.6	No Other Warranties.	39
	11.	Indemnification.	39
	 	11.1	Indemnification by Licensee.	39
	 	11.2	Indemnification by Pfizer.	40
	 	11.3	Indemnification Procedure.	40
	12.	 Limitation of Liability.	41
	 	12.1	Consequential Damages Waiver.	41
	 	12.2	Liability Cap.	41
	13.	Term; Termination.	41
	 	13.1	Term.	41
	 	13.2	Termination for Cause.	41
	 	13.3	Termination for a Bankruptcy Event.	42
	 	13.4	Termination for Convenience.	42
	 	13.5	Effects of Termination.	42
	 	13.6	Survival.	45
	14.	Publicity; Publications.	46
	 	14.1	Use of Names.	46
	 	14.2	Press Releases.	46
	 	14.3	Publications.	46
	15.	Licensee Insurance.	47
	 	15.1	Insurance Requirements.	47
	 	15.2	Policy Notification.	47
	16.	Dispute Resolution.	47
	 	16.1	Arbitration.	47
	 	16.2	No Trial By Jury.	48
	17.	General Provisions.	48


 




     


     


    

 


	 	17.1	Assignment.	48
	 	17.2	Severability.	49
	 	17.3	Governing Law.	49
	 	17.4	Force Majeure.	49
	 	17.5	Waivers and Amendments.	49
	 	17.6	Relationship of the Parties.	50
	 	17.7	Successors and Assigns.	50
	 	17.8	Notices.	50
	 	17.9	Further Assurances.	51
	 	17.10	No Third Party Beneficiary Rights.	51
	 	17.11	Entire Agreement.	52
	 	17.12	Counterparts.	52
	 	17.13	Cumulative Remedies.	52
	 	17.14	Waiver of Rule of Construction.	52


 


List of Schedules


 


Schedule A - Compound


 


Schedule B - Knowledge


 


Schedule C - Licensed Know How


 


Schedule D - Transfer Activities


 


Schedule E - Licensed Patent Rights


 


Schedule F - Initial Development Plan


 


Schedule G - Exceptions


 


Schedule H - GMP Compound


 


Schedule I - IIRs


 


Schedule J - Wire Instructions


 


Schedule K - Schedule K Licensed Know-How


 




     


     


    

 


AMENDED AND RESTATED LICENSE AGREEMENT


 


THIS AMENDED AND RESTATED
LICENSE AGREEMENT (“Agreement”) is made effective as of the 31ST day of July, 2019 (the “Amendment
Effective Date”), by and among SpringWorks Subsidiary 2, Inc., a corporation organized and existing under the laws of
Delaware with offices at 100 Washington Blvd., 5th Floor, Stamford, CT 06902 (“Licensee”), Pfizer
Inc., a corporation organized and existing under the laws of Delaware with offices at 235 East 42nd Street, New York, NY 10017
(“Pfizer Inc.”), Pfizer Products Inc., a corporation organized and existing under the laws of Delaware with
offices at 235 East 42nd Street, New York, NY 10017 (“PPI” and, collectively with Pfizer Inc., “Pfizer”)
and , solely with respect to Article 11 and Sections 3.2 and 3.3, SpringWorks Therapeutics, Inc., a Delaware
corporation (“SpringWorks”). Licensee and Pfizer may, from time-to-time, be individually referred to as a “Party”
and collectively referred to as the “Parties”.


 


RECITALS


 


WHEREAS, Pfizer, Licensee
and SpringWorks (as successor in interest to SpringWorks Therapeutics, LLC) previously entered into a License Agreement, dated
as of August 18, 2017 (the “Original Agreement”), in connection with the formation and capitalization of SpringWorks;


 


WHEREAS, the Parties
desire to amend the Original Agreement to clarify their respective rights and obligations with respect to certain Patent Rights
that comprise or claim Know-How relevant to the Development, Manufacture or use of the Compound or any Product, including without
limitation, Arising Patent Rights (as defined below) and jointly-owned Developed IP; and


 


WHEREAS, Licensee desires
to obtain an exclusive license to the Arising Patent Rights under Section 2.1.1 of the Original Agreement and to clarify their
respective rights and obligations with respect to jointly-owned Developed IP.


 


NOW, THEREFORE, in
consideration of the mutual agreements and covenants set forth herein and other good and valuable consideration, the receipt and
sufficiency of which the Parties hereby acknowledge, the Parties, intending to be legally bound hereby, agree to amend and restate
the Original Agreement as follows:


 


1.          Definitions.


 


1.1           Definitions.


 


“Accounting
Standards” means, as applicable, United States Generally Accepted Accounting Principles or International Financial Reporting
Standards, in each case consistently applied.


 


“Acquisition
Program” is defined in Section 2.8.2.


 


“Active Cases”
is defined in Section 10.2.1.


 




    	1



     


    

 


“Affiliate”
means, with respect to a Party, any Person that, on the Effective Date or during the Term, controls, is controlled by (which Person
is hereby defined to be a “Subsidiary” of such Party), or is under common control with that Party. For the purpose
of this definition, “control” shall refer to: (a) the possession, directly or indirectly, of the power to direct or
cause the direction of the management or policies of an entity, whether through the ownership of voting securities or other ownership
interest, by contract or otherwise, or (b) the ownership, directly or indirectly, of fifty percent (50%) or more of the voting
securities or other ownership interest of such entity. Notwithstanding the foregoing, Pfizer and its Affiliates (other than Licensee-Related
Persons) shall not be considered Affiliates of any Licensee-Related Person for purposes of this Agreement, and Licensee-Related
Persons shall not be considered Affiliates of Pfizer and its Affiliates (other than Licensee-Related Persons) for purposes of this
Agreement, where “Licensee-Related Persons” means Licensee, Licensee’s Subsidiaries, Licensee’s
Parent, Licensee’s Parent’s Subsidiaries and any Person that becomes an Affiliate of Licensee after the Effective Date
as a result of or following a Change of Control of Licensee or Licensee’s Parent.


 


“Agreement”
is defined in the introduction to this Agreement.


 


“Amendment
Effective Date” is defined in the introduction to this Agreement.


 


“Applicable
Law” means any applicable law, statute, rule, regulation, order, judgment, or ordinance of any Governmental Authority.


 


“Arising Patent
Rights” means any Patent Rights that claim Know-How that is within the Licensed Know-How, which Know-How is described
in Schedule K (which may be amended from time to time by agreement of the Parties), but which Patent Rights are, as of the
Effective Date, not included within the Licensed Patent Rights. For avoidance of doubt: (i) Arising Patent Rights must claim Know-How
that is within the Licensed Know-How but may also describe or claim other Know-How and (ii) Patent Rights that are included within
Arising Patent Rights and also describe or claim Developed IP shall be, for all purposes under the Agreement, Arising Patent Rights
and not Developed IP.


 


“Bankruptcy
Code” is defined in Section 13.3.


 


“Bankruptcy
Event” is defined in Section 13.3.


 


“Business
Day” means any day other than (a) a Saturday, (b) a Sunday or (c) a day on which commercial banks located in New York,
New York are authorized or required by Applicable Law to remain closed.


 


“Calendar
Quarter” means the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September
30, and December 31.


 


“Calendar
Year” means each calendar year.


 


“Cell-Based
Use” [***] .


 


[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 


 




    	2



     


    

 


“Change of
Control” means, with respect to a Party (or, where expressly set forth in this Agreement, the Parent of such Party),
whether effected in a single transaction or a series of related transactions: (a) (i) the acquisition of beneficial ownership,
directly or indirectly, by any Person (other than such Party or an Affiliate of such Party) of securities or other voting interest
of such Party representing a majority or more of the combined voting power of such Party’s then- outstanding securities or
other voting interests or (ii) any merger, reorganization, consolidation, share exchange, business combination or similar transaction
involving such Party (or, if applicable, the Parent of such Party) pursuant to which more than fifty percent (50%) of the outstanding
voting securities of such Party (or, if applicable, the Parent of such Party) would be converted into cash or securities of any
other Person, that, in either case (i) or (ii), results in the holders of beneficial ownership of the voting securities or other
voting interests of such Party (or, if applicable, the Parent of such Party) immediately prior to such acquisition, merger, reorganization,
consolidation or business combination ceasing to hold beneficial ownership of at least fifty percent (50%) of the combined voting
power of the surviving entity immediately after such acquisition, merger, reorganization, consolidation, share exchange, business
combination or similar transaction; (c) any sale, lease, exchange, contribution or other transfer (other than the granting of a
license or sublicense) of all or substantially all of the assets of such Party and its Subsidiaries taken as a whole, other than
the sale or disposition of such assets to an Affiliate of such Party; or (d) any sale, lease, exchange, contribution or other transfer
(other than the granting of a license or sublicense) of all or substantially all the assets of such Party and its Subsidiaries
taken as a whole to which this Agreement relates, other than the sale or disposition of such assets to an Affiliate of such Party.


 


“Claims”
is defined in Section 11.1.


 


“Clinical
Trial” means any experiment in which a drug is administered or dispensed to one or more human subjects, including any
Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Clinical Trial, bioequivalence study or bioavailability
study.


 


“CMO”
means a contract manufacturing organization.


 


“Co-Development
Period” is defined in Section 4.8.1.


 


“Combination
Product” means a product that includes or incorporates the Compound or any Product in combination with one (1) or more
Other Active Ingredients (as defined in the definition of Net Sales), whether the Compound or Product(s), on the one hand, and
such Other Active Ingredients, on the other hand, are formulated or packaged together.


 


“Commercialize”
or “Commercialization” means to market, promote, distribute, offer for sale, sell, have sold, import, have imported,
export, have exported or otherwise commercialize a compound or product, or have any of the foregoing done on the relevant Person’s
behalf. When used as a noun, “Commercialization” means any and all activities involved in Commercializing.


 


“Commercially
Reasonable Efforts” means, with respect to the Development or Commercialization of a Product in or for a particular country,
that level of efforts and resources commonly dedicated by a similarly situated company (whether or not a public benefit corporation)
in the research-based pharmaceutical industry to the Development or Commercialization, as the case may be, of a product of similar
commercial potential at a similar stage in its lifecycle in or for such country, in each case taking into account issues of access
to reasonably necessary Know-How (as identified in Schedule C), safety and efficacy, product profile, the proprietary position,
the then- current competitive environment for such product, the likely timing of such product’s entry into the market, the
regulatory environment and the status of such product, the reimbursement and pricing environment, and other relevant scientific,
technical and commercial factors.


 




    	3



     


    

 


“Compliance
Laws” is defined in Section 10.4.


 


“Compound”
means Pfizer’s proprietary gamma secretase inhibitor known as “PF03084014,” with the chemical structure set forth
on Schedule A, and any salt, solvate, hydrate, stereoisomer, prodrug, metabolite, isomer (including optical, enantiomeric,
diastereoisomeric, geometric or tautomeric), polymorph, crystalline form, or any other form thereof.


 


“Confidential
Information” is defined in Section 9.1.


 


“Continuation
Product” means any Product that, as of the date of termination of this Agreement, is in a Clinical Trial, is the subject
of an NDA filing or has been sold in a First Commercial Sale, mutatis mutandis, as described in the table set forth in Section
13.5.2(b).


 


“Continuation
Product Royalty Term” means, with respect to a Continuation Product in a country in the Territory, the period commencing
on the First Commercial Sale, mutatis mutandis, of such Continuation Product in such country, and expiring upon the latest
to occur of: (a) ten (10) years following the date of such First Commercial Sale of such Continuation Product in such country;
(b) the expiration of all regulatory or data exclusivity granted by an applicable Governmental Authority for such Continuation
Product in such country; or (c) the date upon which the Manufacture, use, sale, offer for sale or importation of such Continuation
Product in such country would no longer infringe, but for the license granted herein, a Valid Claim, mutatis mutandis, of
a Licensed Patent Right or Patent Right in Developed IP that is licensed to Pfizer pursuant to Section 13.5.2(b)(ii).


 


“Control”
or “Controlled” means, with respect to any Intellectual Property Rights or other rights to provide data or other
information, the legal authority or right (whether by ownership, license (other than any license granted pursuant to this Agreement)
or otherwise) of a Party (or, as set forth herein, any of its Affiliates) to grant a license or a sublicense of or under such Intellectual
Property Rights to the other Party or provide such data or other information to such other Party, in each case without breaching
the terms of any agreement with a Third Party.


 


“CRO”
means a contract research organization.


 


“Develop”
or “Development” means to conduct any research or development activities with respect to a compound or product
(including activities to import a compound or product for such purpose or to obtain Regulatory Approval for such compound or product),
or to have any of the foregoing done on the relevant Person’s behalf.


 


“Developed
IP” means any Intellectual Property Rights that are conceived or reduced to practice, or otherwise created or developed,
by or on behalf of a Party, its Affiliates or sublicensees, alone or together with one or more Third Parties, during the Term in
connection with the Development, Manufacture, or use of the Compound or any Product.


 


“Development
Exclusion” is defined in Section 2.3.


 




    	4



     


    

 


“Development
Milestone” is defined in Section 5.2.


 


“Development
Milestone Payment” is defined in Section 5.2.


 


“Development
Plan” is defined in Section 4.6.


 


“Disputes”
is defined in Section 16.1.1.


 


“Effective
Date” is August 18, 2017, the effective date of the Original Agreement.


 


“Election
Notice” is defined in Section 7.4.3.


 


“Enabling
Know-How” means any Know-How, other than the Licensed Know-How, that (a) is Controlled by Pfizer or any Existing Pfizer
Affiliates as of the Effective Date that is necessary for Licensee to (i) Exploit the Compound, and any Product, in the form in
which it existed as of the Effective Date, in Field 1 within the Territory and (ii) use, have used, research, Develop, have Developed,
Manufacture, have Manufactured, distribute, have distributed, import, have imported, export or have exported, in each case, for
purposes other than the commercialization of the Compound or any Product, (but, for clarity, not to Manufacture, have Manufactured,
market, have marketed, promote, have promoted, distribute, have distributed, import, have imported, export, have exported, offer
for sale, have offered for sale, sell or have sold for the commercialization of the Compound or any Product) the Compound, or any
Product, in the form which it existed as of the Effective Date, in Field 2 within the Territory, and (b) is provided to Licensee
or any of its Affiliates by Pfizer or any of its Affiliates.


 


“Enabling
Patent Rights” means any Patent Rights, other than the Licensed Patent Rights and Patent Rights in Developed IP, that
are Controlled by Pfizer or any Existing Pfizer Affiliates as of the Effective Date that are necessary for Licensee to (a) Exploit
the Compound, or any Product, in the form in which it existed as of the Effective Date, in Field 1 within the Territory and (a)
use, have used, research, Develop, have Developed, Manufacture, have Manufactured, distribute, have distributed, import, have imported,
export or have exported, in each case, for purposes other than the commercialization of the Compound or any Product, (but, for
clarity, not to Manufacture, have Manufactured, market, have marketed, promote, have promoted, distribute, have distributed, import,
have imported, export, have exported, offer for sale, have offered for sale, sell or have sold for the commercialization of the
Compound or any Product) the Compound, or any Product, in the form which it existed as of the Effective Date, in Field 2 within
the Territory. For clarity, the Enabling Patent Rights are not considered Licensed Patent Rights for purposes of the prosecution,
enforcement or Royalty provisions of this Agreement.


 


“EU”
means the member states of the European Union, as constituted from time to time.


 


“Existing
Pfizer Affiliates” means the Affiliates of Pfizer existing as of the Effective Date.


 


“Exploit”
means to use, have used, research, Develop, have Developed, Manufacture, have Manufactured, Commercialize, have Commercialized
or otherwise exploit.


 


“FD&C
Act” means the United States Federal Food, Drug and Cosmetic Act, as amended.


 




    	5



     


    

 


“FDA”
means the United States Food and Drug Administration, or a successor federal agency thereto.


 


“Field 1”
means the treatment, diagnosis, or prevention of disease in humans or animals for all purposes other than Field 2 and [***].


 


“Field 2”
means the treatment, diagnosis, or prevention of Alzheimer’s Disease, breast cancer and prostate cancer. For clarity, Field
2 does not include [***].


 


“Fields”
means Field 1 and Field 2.


 


“Final Royalty
Payment” is defined in Section 5.12.


 


“Final Royalty
Report” is defined in Section 5.12.


 


“First Commercial
Sale” means, with respect to a Product and a country in the Territory, the first sale of such Product by Licensee or
Licensee’s Affiliate or sublicensee to a Third Party in such country following receipt of Regulatory Approval for such Product
in such country.


 


“Force Majeure
Event” is defined in Section 17.4.


 


“Generic Competition”
means, with respect to a particular country in the Territory, when the Generic Products have, in the aggregate, achieved more than
[***] of the market share in such country by unit volume of combined unit sales of all Products and all Generic Products.


 


“Generic Product”
means, with respect to a particular country in the Territory, any pharmaceutical product that (a) is marketed for sale by a Third
Party not authorized by Licensee, (b) receives Regulatory Approval (with or without pricing or reimbursement approval) in such
country in full or partial reliance on the Regulatory Approval (but not necessarily pricing or reimbursement approval) of a Product,
and (c) is determined by a Regulatory Authority to be therapeutically equivalent to and substitutable with a Product, it being
acknowledged that the foregoing standard is intended to be consistent with the standard set forth in the introduction to the “Orange
Book,” as amended from time to time, or any analogous or comparable standard in any country outside of the United States.
For avoidance of doubt, in the United States, a “Generic Product” as defined herein includes one approved under Section
505(j) of the Federal Food Drug and Cosmetic Act, as supplemented or amended.


 


“Good Manufacturing
Practice” or “GMP” means the regulatory requirements for current good manufacturing practices for
pharmaceuticals promulgated by the FDA, as the same may be amended from time to time, and such standards of good manufacturing
practice as are required by the Regulatory Authorities of the EU and other organizations and Governmental Authorities in countries
in which any Product is intended to be manufactured or sold, to the extent such standards are not less stringent than United States
GMP; provided that a Party shall not be held to any standards required by countries outside the United States and EU unless
such standards have been specifically identified and approved for implementation by the mutual written agreement of the Parties.


 


“Government
Official” is defined in Section 10.4.


 





[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.







 




    	6



     


    

 


“Governmental
Authority” means any United States federal, state or local organization or authority, or any foreign government or any
political subdivision thereof, or any multinational organization or authority, or any authority, agency or commission entitled
to exercise any administrative, executive, judicial, legislative, police, regulatory or taxing authority or power, or any court
or tribunal (or any department, bureau or division thereof), or any governmental arbitrator or arbitral body. For clarity, any
Regulatory Authority shall be a Governmental Authority.


 


“IIRs”
means the Investigator Initiated Research Agreements for the Product in effect as of the Effective Date, set forth on Schedule
I.


 


“Inactive
Case” is defined in Section 7.3.


 


“IND”
means: (a) an investigational new drug application filed with the FDA for authorization for the investigation of any Product, and
(b) any of its foreign equivalents as filed with the applicable Regulatory Authorities in other countries or regulatory jurisdictions
in the Territory, as applicable.


 


“Indemnitee”
is defined in Section 11.3.


 


“Indemnitor”
is defined in Section 11.3.


 


“Initial Period”
is defined in Section 7.4.1.


 


“Intellectual
Property Rights” means all trade secrets, copyrights, Patent Rights, trademarks, moral rights, Know-How and any and all
other intellectual property or proprietary rights now known or hereafter recognized in any jurisdiction.


 


“IPO”
means an initial public offering of stock.


 


“Joint Development
Committee” or “JDC” is defined in Section 4.8.1.


 


“Know-How”
means any invention, discovery, development, data, information, process, method, tangible material, technique, or other know-how,
whether or not patentable.


 


“Knowledge”
means the actual knowledge of the individuals listed on Schedule B, but is not meant to require or imply that any inquiry
or investigation has been undertaken or that any type of search (independent of that performed by the actual Governmental Authority
during the normal course of patent prosecution, as applicable, in a jurisdiction) has been conducted or opinion of counsel obtained.


 


“License Agreements”
means, collectively, (a) this Agreement, (b) the License Agreement by and among SpringWorks Subsidiary 3, Inc., Warner-Lambert
Company LLC, Pfizer Inc. and SpringWorks, dated as of the Effective Date, (c) the License Agreement by and among SpringWorks Subsidiary
1, Inc. (“FAAH Subsidiary”), Pfizer Inc., PPI and SpringWorks, dated as of October 3, 2017 (the “FAAH
Agreement) and (d) the License Agreement by and among SpringWorks Subsidiary 4, Inc. (“Senicapoc Subsidiary”),
Pfizer Inc., Pfizer Research (NC) and SpringWorks, dated as of October 3, 2017 (the “Senicapoc Agreement”).


 




    	7



     


    

 


“License Request”
is defined in Section 13.5.2(b)(ii).


 


“Licensed
Know-How” means all Know-How that is (a) Controlled by Pfizer or any Existing Pfizer Affiliates as of the Effective Date
and (i) listed in Schedule C, or (ii) required to be transferred by Pfizer to Licensee in accordance with Schedule D
or (b) Controlled by Pfizer or any of its Affiliates as of the Effective Date or during the Term and is otherwise provided or made
available to Licensee by Pfizer’s Strategic Operations team via Pfizer’s secure file sharing. For avoidance of doubt,
Licensed Know-How also includes the Know-How Controlled by Pfizer or any Existing Pfizer Affiliate as of the Effective Date described
in Schedule K.


 


“Licensed
Patent Rights” means (a) the Patent Rights listed on Schedule E, (b) all divisionals, continuations, and continuations-in-part
that claim priority to the patent applications described in subsection (a) or the patent applications from which the patents described
in subsection (a) issued, (c) all patents that have issued or in the future issue from any of the foregoing patent applications
in subsections (a) and (b), including utility, model and design patents and certificates of invention, (d) any patents-of-addition,
re-examinations, reissues, renewals, extensions or restorations of any of the foregoing, and (e) any foreign counterparts or equivalents
of any of the foregoing. For clarity, each Inactive Case that is included in Schedule E shall be included in the Licensed
Patent Rights to the extent they are in force as of the Effective Date or can be and are revived and maintained by Licensee in
accordance with this Agreement. All Arising Patent Rights are hereby deemed to constitute part of the Licensed Patent Rights for
all purposes under this Agreement, including the licenses granted in Section 2.1 and the payment obligations in Article
5, but excluding for purposes of the representations and warranties made under Article 10. Schedule E shall be
updated from time-to-time during the Term by Licensee to include patent applications within the Arising Patent Rights.


 


“Licensed
Technology” means, collectively, the Licensed Patent Rights and Licensed Know-How.


 


“Licensee”
is defined in the introduction to this Agreement.


 


“Licensee
Developed IP” means Developed IP Controlled by Licensee during the Term (other than the Pfizer Developed IP that is licensed
to Licensee under Section 2.1).


 


“Licensee
Indemnitees” is defined in Section 11.2.


 


“Major Market”
means each of the following countries: [***].


 


“Manufacture”
or “Manufacturing” means to make, produce, manufacture, process, fill, finish, package, label, perform quality
assurance testing with respect to, release, ship or store a compound or product or any component thereof, or have any of the foregoing
done on the relevant Person’s behalf. When used as a noun, “Manufacture” or “Manufacturing” means
any and all activities involved in Manufacturing a compound or product or any component thereof.


 


“Marginal
Royalty Rate” means the tiered royalty rates set forth in Section 5.4.


 


“Material
New Information” means any statistically significant or material data or information relating to an applicable Product
and resulting from the completion of a Clinical Trial in the Fields, that would increase the probability that such Product would
be further Developed or receive Regulatory Approval.


 


 





[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.




 




    	8



     


    

 


“Milestone
Payments” means, collectively, the Development Milestone Payments and Sales Milestone Payments.


 


“NDA”
means, with respect to a pharmaceutical product, a New Drug Application submitted to the FDA in accordance with the United States
Federal Food, Drug and Cosmetic Act, as amended, and the rules and regulations promulgated thereunder, or any analogous application
or submission with any Regulatory Authority outside of the United States.


 


“Negotiation
Period” is defined in Section 2.6.3.


 


“Net Sales”
means, with respect to all Products distributed or sold in the Territory to Third Parties by Licensee, its Affiliates and sublicensees,
the gross amount invoiced for sales of such Products in the Territory, less in each case (a) sales returns, credits or allowances
actually paid, granted or accrued, including trade, quantity and cash discounts, other adjustments, including those granted on
account of price adjustments, returns, rebates, chargebacks (including for spoiled, damaged, outdated, rejected or returned Product)
or similar payments granted or given to wholesalers or other institutions; (b) adjustments arising from consumer discount programs
or other similar programs; (c) customs or excise duties, value-added taxes, sales taxes, consumption taxes, or other taxes (except
taxes on net income) or duties relating to sales, or any payment in respect of sales provided such duties or taxes are recorded
in gross sales; (d) any payment in respect of sales to the United States government, any state government or any foreign government
or to any other Governmental Authority, or with respect to any government subsidized program or managed- care organization, including
that portion of the annual fee paid under Section 9008 of the United States Patient Protection and Affordable Care Act of 2010
(Pub. L. No. 11-48) that Licensee or its Affiliates or sublicensees reasonably allocate on a pro rata basis to the sales of Products
in accordance with the standard practices of Licensee or its applicable Affiliate or sublicensee as consistently applied across
its respective products; (e) actual freight, shipping, handling and insurance costs up to [***] of Net Sales; (f) discounts or
rebates or other payments required by Applicable Law, including any governmental special medical assistance programs; (g) fee for
service wholesaler fees and inventory management fees paid to Third Party wholesalers, including hospital buying group/group purchasing
organization administration fees; and (h) amounts that are written off as uncollectible in accordance with the accounting procedures
of Licensee or its applicable Affiliate or sublicensee, consistently applied, provided that Licensee, its Affiliate or sublicensee
(as applicable) has made reasonable efforts to collect on such receivable, and provided, further, (1) that if such receivable shall
thereafter be paid or otherwise satisfied, the amount thereof shall be added to Net Sales for the Calendar Quarter in which so
paid or satisfied and (2) such deduction for uncollectible accounts does not exceed [***] of Net Sales. Net Sales shall be determined
from the Licensee’s, or its applicable Affiliate’s or sublicensee’s, books and records maintained in accordance
with Accounting Standards consistently applied.


 


Resales or sales of
a Product made in good faith between or among Licensee, any of its Affiliates or any of its sublicensees shall not be included
in the calculation of Net Sales, but the first sale thereafter to a Third Party (other than a sublicensee) shall be included the
calculation of Net Sales.


 


 





[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.




 




    	9



     


    

 


If the Compound contained
in a Combination Product is sold separately as a Product (a “Compound Product”) in such country and the other
therapeutically active ingredients contained in the Combination Product (“Other Active Ingredient(s)”) are also
sold separately in such country, Net Sales will be calculated by multiplying the total Net Sales (as described above) of the Combination
Product by the fraction A/(A+B), where A is the average gross selling price in such country of the Compound Product sold separately
in the same formulation and dosage, and B is the average gross selling price in such country of such Other Active Ingredient(s)
during the applicable Calendar Year.


 


If the Compound Product
contained in the Combination Product is sold independently of the Other Active Ingredient(s) contained in the Combination Product
in such country, but the average gross selling price of such Other Active Ingredient(s) in such country cannot be determined, Net
Sales will be calculated by multiplying the total Net Sales (as described above) of the Combination Product by the fraction A/C
where A is the average gross selling price in such country of such Compound Product sold independently and C is the average gross
selling price in such country of the entire Combination Product, during the applicable Calendar Year.


 


If the Other Active
Ingredient(s) contained in the Combination Product are sold independently in such country, but there is no applicable Compound
Product in such country (i.e., the Compound contained in the Combination Product is not sold separately as a Product in such country)
or the average gross selling price of the applicable Compound Product in such country cannot be determined, Net Sales will be calculated
by multiplying the total Net Sales (as described above) of the Combination Product by the fraction (1-(B/C)), where B is the average
gross selling price in such country of such Other Active Ingredient(s) and C is the average gross selling price in such country
of the entire Combination Product, during the applicable Calendar Year.


 


If there is no applicable
Compound Product contained in the Combination Product and the Other Active Ingredient(s) contained in the Combination Product are
not sold separately in such country, or the average gross selling price of neither such Compound Product nor such Other Active
Ingredient(s) can be determined in such country, then Net Sales of the Combination Product in such country will be calculated by
mutual agreement of the Parties; provided, that if the Parties cannot reach mutual agreement prior to the end of an applicable
accounting period, such matter shall be resolved in accordance with Section 16.1


 


“Parent”
means (a) with respect to Licensee, any Person that, during the Term, ultimately controls Licensee (which, as of the Effective
Date, is SpringWorks), and (b) with respect to Pfizer, any Person that, during the Term, ultimately controls Pfizer. For the purpose
of this definition, “control” shall refer to: (a) the possession, directly or indirectly, of the power to direct or
cause the direction of the management or policies of Licensee or Pfizer, as applicable, whether through the ownership of voting
securities or other ownership interest, by contract or otherwise, or (b) the ownership, directly or indirectly, of fifty percent
(50%) or more of the voting securities or other ownership interest of Licensee or Pfizer, as applicable, and, “ultimately
control” means that the relevant Person itself is not controlled by another Person.


 


“Party”
and “Parties” is defined in the introduction to this Agreement.


 




    	10



     


    

 


“Patent Rights”
means any and all (a) issued patents, (b) pending patent applications, including all provisional applications, divisions, continuations,
substitutions, continuations-inpart and renewals, and all patents granted thereon, (c) patents-of-addition, re-examinations, reissues
and extensions or restorations by existing or future extension or restoration mechanisms, including patent term adjustments, patent
term extensions, supplementary protection certificates or the equivalent thereof, (d) inventor’s certificates, (e) other
forms of government-issued rights substantially similar to any of the foregoing and (f) United States and foreign counterparts
of any of the foregoing.


 


“Permitted
Third Party Partner” means any academic or non-profit research institution, hospital, CRO, contract manufacturer, contract
employee, consultant or any Third-Party performing services on behalf of Licensee.


 


“Person”
means an individual, corporation, partnership, limited liability company, trust, business trust, association, joint stock company,
joint venture, pool, syndicate, sole proprietorship, unincorporated organization, Governmental Authority, or any other form of
entity not specifically listed herein.


 


“Pfizer”
is defined in the introduction to this Agreement.


 


“Pfizer Cap”
is defined in Section 12.2.


 


“Pfizer Developed
IP” means Developed IP Controlled by Pfizer or any of its Affiliates during the Term. For clarity, any Patent Rights
included in the Pfizer Developed IP are not considered Licensed Patent Rights for purposes of the prosecution, enforcement or Royalty
provisions of this Agreement.


 


“Pfizer Exercise
Period” is defined in Section 2.6.2.


 


“Pfizer Inc.”
is defined in the introduction to this Agreement.


 


“Pfizer Indemnitees”
is defined in Section 11.1.


 


“Pfizer Notice
of Exercise” is defined in Section 2.6.2.


 


“Pharmacovigilance
Agreement” is defined in Section 4.7.


 


“Phase I Clinical
Trial” means a clinical trial that generally provides for the first introduction into humans of a pharmaceutical product
with the primary purpose of determining safety, metabolism and pharmacokinetic properties and clinical pharmacology of such product,
in a manner that is generally consistent with 21 C.F.R. § 312.21(a), as amended (or its successor regulation).


 


“Phase II
Clinical Trial” means a clinical trial, the principal purpose of which is to make a preliminary determination as to whether
a pharmaceutical product is safe for its intended use and to obtain sufficient information about such product’s efficacy,
in a manner that is generally consistent with 21 C.F.R. § 312.21(b), as amended (or its successor regulation), to permit the
design of further clinical trials.


 




    	11



     


    

 


“Phase III
Clinical Trial” means a pivotal clinical trial with a defined dose or a set of defined doses of a pharmaceutical product
designed to ascertain efficacy and safety of such product, in a manner that is generally consistent with 21 C.F.R. § 312.21(c),
as amended (or its successor regulation), for the purpose of enabling the preparation and submission of an NDA.


 


“Phase IV
Clinical Trial” means a clinical trial to delineate additional information about a pharmaceutical product’s risks,
benefits, and optimal use, in a manner that is generally consistent with 21 C.F.R. § 312.85.


 


“PPI”
is defined in the introduction to this Agreement.


 


“Product”
means a product that includes or incorporates the Compound, alone or in combination with one (1) or more other active agents. For
clarity, multiple formulations (or combinations) that contain the same Compound would be deemed one (1) Product for purposes of
any Royalty calculation under Section 5.4 or Section 13.5.2.


 


“Recipients”
is defined in Section 9.2.


 


“Regulatory
Approval” means, with respect to any Product in any country or jurisdiction, any approval, registration, license or authorization
that is required by the applicable Regulatory Authority to market and sell such Product in such country or jurisdiction.


 


“Regulatory
Authority” means any Governmental Authority responsible for granting Regulatory Approvals for any Product in the Territory.


 


“Regulatory
Filings” means, with respect to any Product, any submission to a Regulatory Authority of any appropriate regulatory application,
including, without limitation, any IND, NDA, any submission to a regulatory advisory board, any marketing authorization application,
and any supplement or amendment thereto.


 


“Relevant
Records” is defined in Section 6.1.


 


“Residuals”
is defined in Section 2.4.


 


“Review Period”
is defined in Section 14.3.


 


“Royalties”
is defined in Section 5.4.


 


“Royalty Term”
means, with respect to a Product in a country in the Territory, the period commencing on the First Commercial Sale of such Product
in such country and expiring upon the latest to occur of: (a) ten (10) years following the date of First Commercial Sale of such
Product in such country; (b) the expiration of all regulatory or data exclusivity granted by an applicable Governmental Authority
for such Product in such country; or (c) the date upon which the Manufacture, use, sale, offer for sale or importation of such
Product in such country would no longer infringe, but for the license granted herein, a Valid Claim of a Licensed Patent Right.


 


“Sales Milestone”
is defined in Section 5.3.


 




    	12



     


    

 


“Sales Milestone
Payment” is defined in Section 5.3.


 


“Significant
Transaction” means an exclusive license, an exclusive distribution arrangement, an assignment, a sale, an exclusive promotion
or co-promotion arrangement, or other transfer of all commercial rights to a Product in a Major Market. For the avoidance of doubt,
a research and/or Development license without commercial rights (including rights granted to a Third Party CRO conducting Product-related
research or Development services), the granting of license(s) to Manufacture any Product, and a non-exclusive distribution or promotional
arrangement, or any other activity with an Affiliate or Permitted Third Party Partner, shall not be considered a Significant Transaction.


 


“Significant
Transaction Offer Notice” is defined in Section 2.6.1.


 


“Tax Action”
is defined in Section 5.11.2.


 


“Term”
is defined in Section 13.1.


 


“Terminated
Agreements and MTAs” is defined in Section 10.2.9.


 


“Territory”
means anywhere in the world.


 


“Third Party”
means any Person other than a Party or an Affiliate of a Party. For the avoidance of doubt, Licensee’s Parent is an Affiliate
of Licensee.


 


“Third Party
Acquirer” means a Third Party (a) that has purchased or otherwise controls the rights held by Licensee to the Licensed
Technology, or (b) that acquires all or substantially all of the assets of Licensee.


 


“Third Party
Infringement” is defined in Section 8.1.


 


“Third Party
License” is defined in Section 5.5.2.


 


“Transaction”
means (a) a Change of Control of Licensee, or (b) a transaction to (i) sublicense to a Third Party Acquirer the worldwide right
to (A) Develop and Commercialize the Compound in Field 1 or (B) Develop the Compound in Field 2 or (ii) divest to a Third Party
Acquirer all or substantially all of the assets of Licensee; provided, however, that any Change of Control of Licensee’s
Parent shall not be considered a Transaction.


 


“Transaction
Completion Payment” is defined in Section 5.6.1.


 


“TSA”
is defined in Section 3.3.


 


“United States”,
“US” or “U.S.” means the United States of America, including its districts, territories and
possessions.


 




    	13



     


    

 


“Valid Claim”
means with respect to a particular country, a claim of a Patent Right within the Licensed Patent Rights that (a) with respect to
an issued and unexpired patent, (i) has not been held permanently revoked, unenforceable or invalid by a decision of a court or
other Governmental Authority of competent jurisdiction, which decision is unappealable or has not been appealed within the time
allowed for appeal and (ii) has not expired or been cancelled, withdrawn, abandoned, disclaimed or admitted to be invalid or unenforceable
through reissue, disclaimer or otherwise and (b) with respect to a pending patent application, (i) has not been abandoned or finally
disallowed without the possibility of appeal or refiling of such application and (ii) with respect to any patent application for
which Licensee has provided Pfizer an Election Notice pursuant to Section 7.4.3 and which Pfizer has elected to continue
prosecuting, is not pending more than five (5) years after receipt by Pfizer of such Election Notice.


 


“VAT”
is defined in Section 5.11.1.


 


1.2           Interpretation.


 


Except where the context
requires otherwise, (a) the use of any gender herein shall be deemed to encompass references to any gender, and the use of the
singular shall be deemed to include the plural (and vice versa), (b) the words “include”, “includes”, “including”
and “e.g.” shall be deemed to be followed by the phrase “without limitation”, (c) the word “will”
shall be construed to have the same meaning and effect as the word “shall”, (d) any definition of or reference to any
agreement, instrument or other document herein shall be construed as referring to such agreement, instrument or other document
as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or
modifications set forth herein or therein), (e) any reference herein to any Person shall be construed to include the Person’s
successors and permitted assigns, (f) the words “herein”, “hereof” and “hereunder”, and words
of similar import, shall be construed to refer to this Agreement in its entirety and not to any particular provision hereof, (g)
all references herein to Sections, Exhibits or Schedules shall be construed to refer to Sections, Exhibits or Schedules of this
Agreement, and references to this Agreement include all Exhibits and Schedules hereto, (h) the word “notice” means
notice in writing (whether or not specifically stated) and shall include notices, consents, approvals and other written communications
contemplated under this Agreement, (i) provisions that require that a Party, the Parties or any committee hereunder “agree,”
“consent” or “approve” or the like shall require that such agreement, consent or approval be specific and
in writing, whether by written agreement, letter, approved minutes or otherwise (but excluding e-mail and instant messaging), (j)
references to any specific law, rule or regulation, or article, section or other division thereof, shall be deemed to include the
then current amendments thereto or any replacement or successor law, rule or regulation thereof, and (k) the term “or”
shall be interpreted in the inclusive sense commonly associated with the term “and/or.”


 




    	14



     


    

 


2.          License
Grant.


 


2.1         License
Grants.


 


2.1.1 To Licensee.


 


(a)          Licensed
Technology, Enabling Patent Rights, Enabling Know-How and Pfizer Developed IP. Subject to the terms and conditions of this
Agreement, including Pfizer’s retained rights set forth in Section 2.3, Pfizer hereby grants to Licensee (a) an exclusive
(even as to Pfizer and its Affiliates), sublicensable (subject to Section 2.2), royalty-bearing license under the Licensed
Technology to (i) Exploit the Compound and Products in Field 1 within the Territory and (ii) use, have used, research, Develop,
have Developed, Manufacture, have Manufactured, distribute, have distributed, import, have imported, export and have exported,
in each case for purposes other than the commercialization of the Compound or any Product, (but, for clarity, not to Manufacture,
have Manufactured, market, promote, distribute, have distributed, import, have imported, export, have exported, offer for sale,
have offered for sale, sell or have sold for the commercialization of the Compound or any Product) the Compound and Products in
Field 2 within the Territory, and (b) a non-exclusive, sublicensable (subject to Section 2.2), royalty-free, fully paid-up
license under the Enabling Patent Rights, Enabling Know-How and Pfizer Developed IP to (i) Exploit the Compound and Products in
Field 1 within the Territory and (ii) use, have used, research, Develop, have Developed, Manufacture, have Manufactured, distribute,
have distributed, import, have imported, export and have exported, in each case for purposes other than the commercialization of
the Compound or any Product (but, for clarity, not to Manufacture, have Manufactured, market, promote, distribute, have distributed,
import, have imported, export, have exported, offer for sale, have offered for sale, sell or have sold for the commercialization
of the Compound or any Product) the Compound and Products in Field 2 within the Territory.


 


(b)          Affiliates.
To the extent any of the Licensed Technology, the Enabling Patent Rights, the Enabling Know-How or the Pfizer Developed IP are
Controlled by an Affiliate of Pfizer, then promptly following the Effective Date, Pfizer shall cause such Affiliate to take all
necessary actions to give effect to the licenses granted under this Section 2.1.


 


2.1.2 To Pfizer.
Subject to the terms and conditions of this Agreement, Licensee hereby grants to Pfizer a non-exclusive, sublicensable, royalty-free
license under the Licensee Developed IP to [***] within the Territory. To the extent that any of the Licensee Developed IP is Controlled
by an Affiliate of Licensee, then Licensee shall cause such Affiliate to take all necessary actions to give effect to the license
granted under this Section 2.1.2.


 


2.2         Sublicense
Rights.


 


2.2.1 Subject to this
Section 2.2 and Section 2.6, Licensee may sublicense (directly or to authorize sublicenses through multiple tiers)
or divest the rights granted to it by Pfizer under this Agreement during the Term to any of its Affiliates or to any Third Party
without Pfizer’s approval.


 


2.2.2 All sublicenses
shall be subject to and consistent with the terms and conditions of this Agreement.


 


2.2.3 In no event shall
any sublicense relieve Licensee of any of its obligations under this Agreement.


 


2.2.4 Licensee shall
furnish to Pfizer a true and complete copy of each sublicense agreement entered into by Licensee with respect to the Licensed Technology
and each amendment thereto, within thirty (30) days after the sublicense or amendment has been executed.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	15



     


    

 


2.3           Retained
Rights.


 


Subject to Section
2.8, Licensee acknowledges and agrees that (a) Pfizer retains (i) the right to Commercialize (including to Manufacture or have
Manufactured for commercialization) the Compound or any Product in Field 2 in any jurisdiction within the Territory if Licensee
or any of its Affiliates or sublicensees receives Regulatory Approval for the Compound or such Product, respectively, in Field
2 in such jurisdiction and (ii) the exclusive right to [***] within the Territory, and, in the case of (i) and (ii), including
the right to sublicense or otherwise partner the foregoing retained rights to or with Third Parties, including fee-for-services
services providers such as CROs, CMOs, and contract sales representatives to perform activities on Pfizer’s and its sublicensees’
and partners’ behalf, (b) Pfizer retains the right to make, have made, use and import the Compound and Products for Pfizer’s
internal research purposes in the Fields; provided, that Pfizer shall not have the right to conduct any Clinical Trial administering
the Compound or any Product in the Fields unless the applicable Product is commercially available and Pfizer conducts the applicable
Clinical Trial using Product purchased through normal commercial channels (the “Development Exclusion”), (c)
Pfizer is free to use the Licensed Patent Rights and Licensed Know-How for purposes other than those exclusively licensed to Licensee
under this Agreement, and (d) Pfizer retains the right to permit Sigma Aldrich Co. or Pfizer’s other existing reagent suppliers
to sell the Compound to any noncommercial entity (which would have the right to use such Compound), in each case in the form of
non-GMP samples of the Compound in mg quantities solely as a research reagent.


 


Notwithstanding anything
to the contrary in this Agreement, except for the Development Exclusion and except as set forth in Section 2.8, nothing
in this Agreement shall be deemed to prevent or restrict in any way the ability of Pfizer or its Affiliates to conduct any activities
in the Territory which would be permitted under any safe harbor, research exemption, government or executive declaration of urgent
public health need, or any similar right available in law or in equity, if such activity were conducted by a Third Party (i.e.,
based on publicly available information, other than any such information that became public due to any breach by Pfizer of this
Agreement, including any breach of Article 9). For the avoidance of doubt, except to the extent permitted in this Section
2.3, following the Effective Date, in no event shall Pfizer or any of its Affiliates enter into any agreement with any Third
Party regarding, or otherwise permit the initiation of, any investigator- initiated Clinical Trial administering the Compound or
any Product (other than for Cell-Based Use), unless Licensee has approved such activities in advance in writing. For the avoidance
of doubt, Pfizer may conduct Clinical Trials to Develop or otherwise Exploit the Compound or any Product for Cell-Based Uses.


 


2.4           Residuals.


 


Subject to Section
2.8, Pfizer may use the Residuals resulting from Pfizer’s access to or work with the Product for any purpose other than
(a) Exploiting the Compound or any Product in Field 1 (for the avoidance of doubt, excluding [***]) in the Territory during the
Term and (b) Exploiting the Compound or any Product in Field 2 (for the avoidance of doubt, excluding Cell-Based Use) in the Territory
during the Term in any manner other than that set forth in Section 2.3(a)(i); provided, however, that nothing
in this Section 2.4 grants Pfizer any rights in or licenses to any Patent Rights Controlled by Licensee or any of its Affiliates
or sublicensees. Licensee may use the Residuals for any purpose; provided, however, that nothing in this Section 2.4
grants Licensee any rights in or licenses to any Patent Rights Controlled by Pfizer or any of its Affiliates. As used herein, “Residuals”
means information in non-tangible form which may be retained in the memories of the relevant Party’s employees or consultants
who have had access to the Products or Licensed Know-How, including such information in the form of ideas, concepts, know-how or
techniques.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	16



     


    

 


2.5          No
Additional Rights.


 


Nothing in this Agreement
shall be construed to confer any rights upon any Party by implication, estoppel, or otherwise as to any technology or Intellectual
Property Rights of the other Party or its Affiliates, other than the rights in Licensed Technology, the Enabling Patent Rights,
the Enabling Know-How, the Pfizer Developed IP and the Residuals expressly granted to Licensee herein, regardless of whether such
technology or Intellectual Property Rights shall be dominant or subordinate to any Licensed Technology, Enabling Patent Rights,
Enabling Know-How and Pfizer Developed IP.


 


2.6          Right
of First Negotiation.


 


Subject to the terms
and conditions of this Agreement, Licensee hereby grants to Pfizer an exclusive right of first offer to negotiate and enter into
an agreement for a Significant Transaction, subject to the terms and conditions set forth in this Section 2.6, including
Section 2.6.6.


 


2.6.1 Prior to entering
into negotiations with a Third Party for a Significant Transaction for a Product in a Major Market, Licensee shall provide Pfizer
with (a) written notice of the nature of the proposed Significant Transaction, (b) the Product and the Major Market (or Major Markets)
for which the Significant Transaction is sought, and (c) a summary of the most recent material clinical data for the relevant Product
within Licensee’s possession and control (such notice together with the related information, the “Significant Transaction
Offer Notice”).


 


2.6.2 If Pfizer has a
good faith desire to obtain rights to the Product in the Major Market (or Major Markets) as set forth in the Significant Transaction
Offer Notice, then Pfizer may notify Licensee within twenty (20) days of the receipt of the Significant Transaction Offer Notice
(the “Pfizer Exercise Period”) that it desires to enter into negotiations with respect to such Significant Transaction
(the “Pfizer Notice of Exercise”).


 


2.6.3 If Pfizer provides
the Pfizer Notice of Exercise to Licensee in accordance with Section 2.6.2, then (a) from and after the receipt of the Pfizer
Notice of Exercise and for a continuous period of [***] thereafter (the “Negotiation Period”), the Parties will
negotiate exclusively with each other with respect to such Significant Transaction in good faith and with the intent of entering
into a mutually acceptable definitive, written agreement with respect to the Significant Transaction, and (b) if the Parties do
not enter into a Significant Transaction within the Negotiation Period, then Licensee may negotiate and enter into a Significant
Transaction with a Third Party for the Product and the Major Market (or Major Markets) set forth in the Significant Transaction
Offer Notice; provided, that, for a period of nine (9) months from the expiration of the Negotiation Period, Licensee shall
not enter into an agreement with a Third Party with respect to the applicable Product in the Major Market (or Major Markets) set
forth in the Significant Transaction Offer Notice on economic terms and conditions that, when viewed as a whole, are less favorable
to Licensee as compared to the terms and conditions in the last proposal submitted by Pfizer to Licensee with respect thereto during
the Negotiation Period.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	17



     


    

 


2.6.4 If Pfizer does
not provide the Pfizer Notice of Exercise to Licensee in accordance with Section 2.6.2, then Licensee may negotiate and
enter into a Significant Transaction with a Third Party for the Product and the Major Market (or Major Markets) set forth in the
Significant Transaction Offer Notice; provided, that, (a) if Licensee fails to enter into a Significant Transaction with
a Third Party with respect to the applicable Product in one (1) or more of the applicable Major Markets within [***] after the
expiration of the Pfizer Exercise Period, then Pfizer’s right of first negotiation pursuant to this Section 2.6 shall
be reinstated with respect to a Significant Transaction for such Product for those applicable Major Markets for which Licensee
had not entered into a Significant Transaction with a Third Party, or (b) if Material New Information becomes available relating
to the applicable Product before Licensee enters into a Significant Transaction for such Product with a Third Party covering one
or more of the Major Markets described in the Significant Transaction Offer Notice, then Pfizer’s right of first negotiation
pursuant to this Section 2.6 shall be reinstated with respect to a Significant Transaction for such Product for those applicable
Major Markets for which Licensee had not entered into a Significant Transaction with a Third Party.


 


2.6.5 The rights granted
to Pfizer under this Section 2.6 shall terminate (a) in their entirety on the earliest of (i) an IPO of Licensee or its
Parent, (ii) a sale of all or substantially all of the assets of Licensee that relate to the Products, (iii) a Change of Control
of Licensee, or (iv) the first filing of an NDA for any Product in any Major Market, and (b) with respect to any Product in any
Major Market, upon Licensee granting a Third Party a sublicense to Commercialize such Product in such Major Market in accordance
with this Section 2.6.


 


2.6.6 For clarity, (a)
nothing shall prevent Licensee or any of its Affiliates from negotiating or executing any confidentiality agreement or participating
in general discussions (not focused on a Significant Transaction) with any prospective partner, investor, licensor, licensee or
other Third Party, (b) Licensee shall have no obligation to provide Pfizer with (i) the identity of any Third Party or (ii) except
(A) as required to be set forth in a Significant Transaction Offer Notice or (B) as required in discovery in the event of a dispute
between the Parties as to whether Pfizer’s rights under this Section 2.6 have been triggered, any terms of any transaction
negotiated with a Third Party, and (c) if Pfizer provides the Pfizer Notice of Exercise with respect to a Product and a Major Market,
Pfizer shall have no more than one (1) opportunity to negotiate a Significant Transaction for such Product in such Major Market.


 


For the purposes of this Section 2.6
only, “Third Party” shall mean any Person other than (a) a Party or an Affiliate of a Party, or (b) a Permitted Third
Party Partner.


 


2.7           365(n)
Rights.


 


All rights granted
under this Agreement by Pfizer are, for the purposes of Article 365(n) of the Bankruptcy Code, licenses of rights to “intellectual
property” as defined under Article 101 of the Bankruptcy Code. The Parties agree that Licensee will retain, and may fully
exercise, all of its rights and elections as a licensee under the Bankruptcy Code.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	18



     


    

 


2.8          Exclusivity.


 


2.8.1 Subject to Section
2.8.2 and Section 2.8.3, for ten (10) years following the Effective Date, neither Pfizer nor any of its Affiliates shall,
without the prior written consent of Licensee, conduct Clinical Trial of any compound that is a gamma secretase inhibitor, or any
product that includes or incorporates a gamma secretase inhibitor, for the treatment, diagnosis or prevention of desmoid tumors.


 


2.8.2 If a Change of
Control occurs with respect to Pfizer and a Third Party, or if Pfizer or any Existing Pfizer Affiliates acquires or merges with
a Third Party, and such Third Party is, at the time of such Change in Control or acquisition or merger, conducting activities that
would, if conducted by Pfizer or any of its Affiliates, cause Pfizer or one of its Affiliates to violate Section 2.8.1
or conducting studies in desmoid tumor animal models for the treatment, diagnosis or prevention of desmoid tumors with any compound
that is a gamma secretase inhibitor (such activities, an “Acquisition Program”), then Pfizer and/or such Third
Party once it is an Affiliate of Pfizer will be permitted to continue such Acquisition Program and such continuation will not constitute
a violation of Section 2.8.1; provided that (a) no Licensed Technology is used in such Acquisition Program, (b) no
Confidential Information of Licensee is used in such Acquisition Program and (c) neither the Compound nor any Product is used in
such Acquisition Program. For purposes of this Section 2.8.2, the term “acquires” shall include an acquisition
of the assets of a Third Party; provided, that the Acquisition Program does not constitute more than ten percent (10%) of
the value of the assets acquired from the Third Party, and the assets acquired by Pfizer or its Existing Pfizer Affiliates from
such Third Party constitute all the assets of such Third Party related to the Acquisition Program.


 


2.8.3 From and after
the date on which a Change of Control occurs with respect to Licensee, if any, the obligations set forth in Section 2.8.1
shall no longer apply to Pfizer or its Affiliates.


 


3.          Transfer
Activities.


 


3.1           Transfer
Activities Schedules.


 


Schedule C and
Schedule D sets forth the documentation, materials and other Know-How that Pfizer will transfer to Licensee, and Schedule
D sets forth the personnel support to be provided by Pfizer, and related activities to be performed by the Parties with respect
thereto.


 


3.2           Compassionate
Use and IIRs.


 


Following the Effective
Date until the execution of the TSA, the Parties agree that Pfizer and/or its Existing Pfizer Affiliates will be responsible for
(a) administering the compassionate use program, including without limitation ensuring appropriate clinical supply of the Compound
and/or Products for the program and using the current protocol therefor to determine whether or not to accept new compassionate
use requests, for all compassionate use patients receiving the Product during such period, and (b) supporting and maintaining all
IIRs in effect as of the Effective Date.


 




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3.3           Transition
and Assignment Agreements.


 


Within thirty (30)
days after the Effective Date, the Parties shall negotiate in good faith and execute (a) an assignment agreement between Pfizer
(and/or one of its Existing Pfizer Affiliates), pursuant to which Pfizer and/or one of its Existing Pfizer Affiliates will assign
to Licensee and Licensee will assume all agreements listed therein; (b) a transitional services agreement between Pfizer Inc. and
SpringWorks, pursuant to which Pfizer Inc. will, consistent with its past practices, support the IIRs and administer the program
of compassionate use as described therein (the “TSA”); and (c) a quality agreement between Pfizer and Licensee,
which will govern the roles and responsibilities of the Parties with respect to GMP materials transferred to Licensee by Pfizer.


 


3.4           Terminated
Agreements and MTAs.


 


Within sixty (60) days
after the Effective Date, Pfizer shall use commercially reasonable efforts to identify and provide to Licensee all Terminated Agreements
and MTAs that might limit any license right granted to Licensee or its Affiliates under this Agreement, including any nonexclusive
rights granted that would impact the exclusive rights granted to Licensee hereunder.


 


4.          Development;
Commercialization; Manufacturing.


 


4.1           General.


 


Subject to the terms
of this Agreement, including Sections 2.3 and 4.2 and Article 3, Licensee shall have sole responsibility for
the cost and expense of, and the sole authority over and control of, (a) the Development, Manufacture (except for any existing
supply of the Compound transferred as part of the transfer activities set forth on Schedule D) and Regulatory Approval of
the Compound and Products in the Fields (for the avoidance of doubt, excluding Cell Based Uses) in the Territory, and (b) the Commercialization
of the Compound and Products in Field 1 in the Territory.


 


4.2           Diligence.


 


4.2.1 Development
and Commercialization in the United States. Licensee shall, itself or through its Affiliates or sublicensees, use Commercially
Reasonable Efforts to (a) pursuant to the Development Plan, Develop and seek Regulatory Approval, including, as applicable, pricing
and reimbursement approval, for at least one (1) Product in Field 1 in the United States, and (b) Commercialize each Product in
Field 1 in the United States for which Licensee or its designated Affiliates or sublicensees have received Regulatory Approval,
including pricing and reimbursement approval.


 


4.2.2 Development
and Commercialization in Other Major Markets. If Licensee reasonably anticipates that a Product that has received Regulatory
Approval in the United States in Field 1, including, as applicable, pricing and reimbursement approval, will receive reimbursement
in any other Maj or Market in Field 1 at [***] or more of the United States price for such Product, then Licensee shall, itself
or through its Affiliates or sublicensees, use Commercially Reasonable Efforts to (a) pursuant to the Development Plan, Develop
and seek Regulatory Approval, including pricing and reimbursement approval, for one (1) such Product in Field 1 in one (1) such
other Major Market, and (b) if Licensee or its designated Affiliates or sublicensees have received Regulatory Approval, including
pricing and reimbursement approval, for such Product in Field 1 in any such other Major Market, Commercialize such Product in Field
1 in any such other Major Market.


 








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competitively harmful if publicly disclosed.


 



 




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4.3           Regulatory
Filings.


 


In connection with
its efforts to Develop the Product, Licensee shall bear all responsibility and expense for submitting Regulatory Filings and obtaining
Regulatory Approval for the Products. Upon the effective date of transfer of the Regulatory Filings, Licensee shall be responsible
for maintaining at its sole expense such Regulatory Filings transferred to Licensee pursuant to Schedule D.


 


4.4           Progress
Reporting.


 


During the Term, (a)
at least ninety (90) days after the start of each Calendar Year, Licensee shall provide to Pfizer a report including (i) an update
on the progress of Licensee’s Development and Commercialization activities, including key achievements and milestones reached
(as reasonably determined by Licensee), in the prior Calendar Year and Clinical Trials that were conducted or in progress in such
prior Calendar Year, and (ii) a summary of the planned Development and Commercialization activities for the current Calendar Year,
including key achievements and milestones that are expected and studies planned; and (b) at least ninety (90) days prior to the
start of each Calendar Year, Licensee shall provide to Pfizer a non-binding three (3) year forecast of payments that are anticipated
to be made to Pfizer pursuant to Sections 5.2 and 5.3, which forecast shall be reported on a Calendar Quarter basis
for the first year of such forecast and on a Calendar Year basis for the second and third years of such forecast.


 


4.5           CROs
and CMOs.


 


Licensee may contract
with Third Party CROs or CMOs to handle certain clinical Development or Manufacturing activities, in Licensee’s reasonable
discretion, consistent with the then-current Development Plan. As between the Parties, all costs of such CROs or CMOs will be borne
solely by Licensee. For clarity, Licensee shall not be required to obtain Pfizer’s consent for a sublicense to a CRO or CMO.


 


4.6           Development
Plan.


 


Licensee will, itself
or through its Affiliates or sublicensees, Develop and Commercialize the Compound and Products in Field 1, consistent with the
terms and conditions set forth in this Section 4.6 and the development plan as set forth in Schedule F, as amended
by Licensee pursuant to this Section 4.6 (the “Development Plan”). Each updated Development Plan shall
include all Development and Commercialization activities, in a similar amount of detail as in the draft of the Development Plan
set forth in Schedule F as of the Effective Date, that are reasonably anticipated to be undertaken by Licensee to advance
the Compound or a Product. Licensee will provide Pfizer with an updated Development Plan once per Calendar Year. To the extent
Licensee substantively changes the Development Plan, Licensee will provide Pfizer with such changed Development Plan within thirty
(30) days of the occurrence of such substantive change. For purposes of this Section 4.6, a “substantive change”
means only the following: (a) an increase or decrease of more than twenty percent (20%) in Licensee’s then-current Development
or Commercialization activities budget; (b) an anticipated delay of more than three (3) months in any Development Milestone, as
compared with the timeline set forth in the most recent version of the Development Plan received by Pfizer; (c) elimination of
any country(ies) in which the Development or Commercialization activities are planned; and (d) the addition or deletion of an indication
in the Fields that is being pursued under the Development Plan. The obligations set forth in this Section 4.6 shall expire
on the First Commercial Sale of any Product in the U.S.; provided, however, that, if Licensee is required to obtain
Regulatory Approval of such Product in a Major Market in accordance with Section 4.2.2, the obligations set forth in this
Section 4.6 shall expire (other than with respect to the U.S.) with respect to such Product on the First Commercial Sale
of such Product in the first Major Market (other than the U.S.).


 




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4.7          Pharmacovigilance
Agreement.


 


Within three (3) months
after the Effective Date, the Parties will in good faith negotiate and finalize a separate pharmacovigilance agreement (the “Pharmacovigilance
Agreement”), the terms of which shall set forth the obligations, procedures and timelines for exchanging information
pertaining to safety reporting obligations observed in connection with the Compound and each Product.


 


4.8          Joint
Development Committee.


 


4.8.1 Responsibilities.
If, at any time during the Term, Pfizer desires to conduct Development activities with respect to the Compound or Product for [***]
(any time when such Development activities are being conducted, the “Co-Development Period”), the Parties shall
establish a committee (the “Joint Development Committee” or “JDC”) to provide a forum for
the Parties to discuss the Development of the Compound and Products both inside and outside the Fields, including (a) Clinical
Trials planned by either Party, and (b) the exchange of information relating to adverse events and safety issues that may arise
during the course of such Development. The JDC shall continue to exist and meet in accordance with this Section 4.8 during
the Co-Development Period.


 


4.8.2 Membership.
The JDC shall be comprised of two (2) representatives (or such other number of representatives as the Parties may agree in writing)
from each of Pfizer and Licensee. Each Party may replace any or all of its representatives on the JDC at any time upon written
notice to the other Party. Any member of the JDC may designate a substitute representative to attend and perform the functions
of that member at any meeting of the JDC. Each Party may invite non-member representatives of such Party to attend meetings of
the JDC; provided that there is a reasonable need for such non-member representative to attend a meeting based on the expected
agenda for the meeting. Each Party shall subject its member and nonmember representatives to confidentiality obligations no less
restrictive than the confidentiality obligations set forth in Article 9.


 








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competitively harmful if publicly disclosed.


 



 




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4.8.3 Meetings.
During the Co-Development Period, the JDC shall meet at least once each Calendar Quarter, and more or less frequently as the Parties
mutually deem appropriate, on such dates, and at such places and times, as the Parties shall agree. Meetings of the JDC may occur
in person, by telephone or by video conference. Each Party shall bear all expenses it incurs in regards to participating in all
meetings of the JDC.


 


4.8.4 Minutes.
Unless otherwise agreed, the Parties will alternate responsibility for preparing and circulating draft minutes of each meeting
of the JDC, including a summary description of the discussions at the meeting.


 


4.8.5 Decision-Making
Authority. The Parties acknowledge and agree that the JDC is solely a forum for discussion between the Parties and that (a)
Licensee retains sole decision-making authority with respect to the Compound and Products in the Fields in the Territory, in each
case consistent with the license granted to Licensee in Section 2.1, and (b) Pfizer retains sole decision-making authority
with respect to the Compound and Products for [***] and for any other uses for which Pfizer has retained rights as set forth in
Section 2.3.


 


5.          Payment
Terms.


 


5.1           Transfer
Activities Payments.


 


In consideration of
the transfer activities to be performed by Pfizer pursuant to Schedule D, Licensee shall pay to Pfizer the amounts set forth
in Schedule D.


 


5.2           Development
Milestone Payments.


 


In consideration of
the licenses and rights granted to Licensee hereunder, Licensee shall pay to Pfizer the amounts set forth below following the first
occurrence of each event described in the first column below by, as applicable, Licensee, any Affiliate of Licensee, any sublicensee
of Licensee or any Third Party Acquirer (each such event, a “Development Milestone” and each payment, a “Development
Milestone Payment”).


 


	DEVELOPMENT MILESTONE (IN EACH CASE APPLICABLE ONLY TO THE FIRST PRODUCT TO ACHIEVE SUCH EVENT IN THE FIRST INDICATION IN THE FIELDS)	 	DEVELOPMENT MILESTONE PAYMENT IF THE RELEVANT DEVELOPMENT MILESTONE IS ACHIEVED BY LICENSEE’S PARENT, LICENSEE, OR ANY AFFILIATE OF LICENSEE	 	DEVELOPMENT MILESTONE PAYMENT IF THE RELEVANT DEVELOPMENT MILESTONE IS ACHIEVED BY A THIRD PARTY SUBLICENSEE OR BY A THIRD PARTY ACQUIRER (OTHER THAN SPRINGWORKS)
	(1) [***]	 	U.S. $[***]	 	U.S. $[***]*
	(2) First Commercial Sale of a Product [***] in the Fields **	 	U.S. $[***]***
	(3) First Commercial Sale of a Product [***] in the Fields **	 	U.S. $[***]
	(4) First Commercial Sale of a Product [***] in the Fields **	 	U.S. $[***]
	(5) First Commercial Sale of a Product in [***] in the Fields **	 	U.S. $[***]


 


For the avoidance of
doubt, each Development Milestone Payment shall be payable only once upon the first achievement of the applicable Development Milestone,
regardless of the number of Products that achieve such Development Milestone or the number of indications for which such Development
Milestone is achieved. The total amount payable with respect to these Development Milestones shall not exceed U.S. $22,500,000,
or U.S. $28,000,000 if the Development Milestone in clause (1) above is achieved by a Third Party sublicensee or a Third Party
Acquirer.


 








[***]
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competitively harmful if publicly disclosed.


 



 




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* Such Development
Milestone Payment shall only be payable if, prior to achieving this Development Milestone, a Third Party Acquirer sublicenses rights
to Develop and, to the extent permissible under the license granted to Licensee in Section 2.1, Commercialize the Compound
worldwide in the Fields or acquires all or substantially all of the assets of Licensee and (a) subsequently achieves this Development
Milestone or (b) achieves the first to occur of a Development Milestone in row (2), (3), (4) or (5) above prior to (i) Licensee,
any of its Affiliates, any of its sublicensees or any Third Party Acquirer dosing any patient in any Phase III Clinical Trial for
a Product or (ii) Licensee filing the first NDA with respect to the first Product.


 


** The Development
Milestone Payment corresponding to this Development Milestone shall be due on the one hundred eighty-first (181st) day after the
First Commercial Sale of the applicable Product in the applicable jurisdiction.


 


*** Up to U.S. $5,000,000
of such Development Milestone Payment may be paid by Licensee in equity of Licensee, subject to mutual agreement of the Parties
on the terms and conditions of the issuance of such equity to Pfizer.


 


Except as set forth
above, each Development Milestone Payment shall be payable by Licensee within sixty (60) days after the achievement of the corresponding
Development Milestone, and such payment shall be accompanied by a report identifying the amount payable to Pfizer under this Section
5.2.


 


5.3           Sales
Milestone Payments.


 


In consideration of
the licenses and rights granted to Licensee hereunder, Licensee shall pay to Pfizer the following one-time payments when aggregate
Net Sales of Products in the Territory during a Calendar Year first reach the respective thresholds indicated below (each event
in the first column below, a “Sales Milestone” and each payment, a “Sales Milestone Payment”).


 


	SALES MILESTONE	 	SALES MILESTONE PAYMENT
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]
	Aggregate Net Sales during a Calendar Year first exceed U.S. $[***]	 	U.S. $[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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For the avoidance of
doubt, each Sales Milestone Payment shall be paid only once upon the first achievement of the applicable Sales Milestone. The total
amount payable with respect to these Sales Milestones shall not exceed U.S. $210,000,000.


 


If more than one (1)
Sales Milestone is first achieved in a particular Calendar Year (e.g., aggregate Net Sales of Products in the Calendar Year after
the First Commercial Sale of the first Product exceed U.S. $[***]), then all unpaid Sales Milestone Payments first achieved in
such Calendar Year shall become payable.


 


Each Sales Milestone
Payment shall be payable by Licensee within sixty (60) days after the end of the applicable Calendar Quarter in which cumulative
Net Sales reach the applicable threshold, and such payment shall be accompanied by a report identifying the amount payable to Pfizer
under this Section 5.3.


 


5.4           Royalty
Payments.


 


Subject to Section 5.5, in consideration
of the licenses and rights granted to Licensee hereunder, Licensee shall pay to Pfizer royalties in the amount of the Marginal
Royalty Rates set forth below (each, a “Marginal Royalty Rate”) on the aggregate Net Sales resulting from the
sale of Products in the Territory during each Calendar Year (collectively, “Royalties”).


 


	NET SALES	 	 	MARGINAL ROYALTY RATE	 
	Net Sales up to and including U.S. $[***] per Calendar Year	 	 	[***]	%
	Net Sales above U.S. $[***] up to and including U.S. $[***] per Calendar Year	 	 	[***]	%
	Net Sales above U.S. $[***] up to and including U.S. $[***] per Calendar Year	 	 	[***]	%
	Net Sales above U.S. $[***] up to and including U.S. $[***] per Calendar Year	 	 	[***]	%
	Net Sales above U.S. $[***] per Calendar Year	 	 	[***]	%



 


Each Marginal Royalty
Rate set forth in the table above shall apply only to that portion of the Net Sales of all Products in the Territory during a given
Calendar Year that falls within the indicated range. For example, if, during a Calendar Year, aggregate Net Sales of a Product
were equal to U.S. $[***], then the royalties payable by Licensee would be calculated by adding (a) the royalties with respect
to the first $[***] at the first-tier percentage of [***] percent ([***]%), equal to U.S. $[***], and (b) the royalties with respect
to the next U.S. $[***] at the second- tier percentage of [***] percent ([***]%), equal to U.S. $[***], for a total royalty of
U.S. $[***].


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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Subject to Section
5.12, Licensee shall pay to Pfizer the applicable Royalties within sixty (60) days following the expiration of each Calendar
Quarter after the date of the First Commercial Sale of the relevant Product in any country in the Territory. Royalties will be
payable on a Product-by-Product and country-by-country basis during the Royalty Term for such Product in such country until the
expiration of the Royalty Term for such Product in such country. All Royalty payments shall be accompanied by a report that includes
reasonably detailed information regarding the calculation of Net Sales of the applicable Products (including all deductions), calculation
of any deductions applicable under Section 5.5, and all Royalties payable to Pfizer for the applicable Calendar Quarter
(including any foreign exchange rates employed).


 


5.5          Royalty
Deductions.


 


5.5.1 Expiration of
Valid Claims and Exclusivity. If, on a country-by-country and Product-by-Product basis, the Royalty Term for such Product in
such country is only being calculated under subsection (a) of the definition of Royalty Term (i.e., all regulatory and data exclusivity
granted by an applicable Governmental Authority for such Product in such country has expired and the Manufacture, use, sale, offer
for sale or importation of such Product in such country would no longer infringe, but for the license granted herein, a Valid Claim
of a Licensed Patent Right), then the Marginal Royalty Rates used to calculate Royalties with respect to such Product in such country
shall by reduced by [***].


 


5.5.2 Third Party
Licenses. Licensee, its Affiliates and sublicensees shall have the right to obtain a license under any Third Party Intellectual
Property Rights that Licensee, or any of its Affiliates or sublicensees, deems reasonably necessary or useful in order to research,
Develop, Manufacture, Commercialize (to the extent permissible under the license granted to Licensee in Section 2.1) or
use any Product in any Field in the Territory (each such license, a “Third Party License”). Licensee, or its
applicable Affiliate or sublicensee, shall pay all amounts due under Third Party Licenses; provided, that Licensee shall
be entitled to reduce the Royalties due to Pfizer upon Net Sales of a Product by up to [***] of the total royalties paid by Licensee,
or any of its Affiliates or sublicensees, to a Third Party with respect to such Product under any Third Party License.


 


5.5.3 Generic Competition.
If at any time during the Royalty Term Generic Competition exists in a given country with respect to a Product, then the Marginal
Royalty Rates used to calculate Royalties for such Product in such country shall be reduced by [***] for so long as such Generic
Competition exists.


 


5.5.4 Maximum Deductions.
Notwithstanding Sections 5.5.1, 5.5.2 and 5.5.3 to the contrary, under no circumstances shall the reductions set
forth in this Section 5.5 cause (a) the total Royalties payable to Pfizer in any Calendar Quarter to be reduced by more
than [***] ([***]%) of the amount that would otherwise be due without giving effect to this Section 5.5, or (b) the Marginal
Royalty Rates used to calculate Royalties in any Calendar Quarter to be reduced by more than [***] ([***]%) of the rates set forth
in Section 5.4 (i.e., [***]%, [***]%, [***]%, [***]% and [***]%, respectively).


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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5.6          Transaction
Completion Payment.


 


5.6.1 If, at any time
prior to eighteen (18) months after the Effective Date, Licensee completes a Transaction, Licensee shall pay to Pfizer a one-time,
non-refundable and non- creditable payment in the amount of the lesser of (a) [***] of the total consideration received by Licensee
or its Affiliates with respect to the relevant Transaction, or (b) [***] U.S. Dollars (U.S. $[***]) (the “Transaction
Completion Payment”).


 


5.6.2 For clarity, (a)
should Licensee complete its IPO prior to the occurrence of the Change of Control of Licensee, no Transaction Completion Payment
would be owed upon completion of such Change of Control or thereafter, and (b) the Transaction Completion Payment shall be payable
no more than once.


 


5.6.3 Any Transaction
Completion Payment shall be accompanied by a copy of any relevant documents necessary to allow Pfizer to confirm the accuracy of
such payment.


 


5.6.4 For a Transaction
Completion Payment due as a result of a Transaction covered by subsection (a) of the Transaction definition, Licensee or its Affiliate
shall make such Transaction Completion Payment within sixty (60) days following the closing of Licensee’s Change of Control.


 


5.6.5 For a Transaction
Completion Payment due as a result of a Transaction covered by subsection (b) of the Transaction definition, Licensee or its Affiliate
shall make such Transaction Completion Payment within sixty (60) days following the receipt of the consideration payable in connection
with such Transaction.


 


5.6.6 Licensee may credit
against any Transaction Completion Payment [***] of any Development Milestone Payments or Sales Milestone Payments previously paid
to Pfizer pursuant to Sections 5.2 and 5.3, up to [***] of the total of such Transaction Completion Payment.


 


5.7          Other
Payments.


 


Except as otherwise
set forth in this Agreement, each Party shall pay to the other Party any amounts due under this Agreement within sixty (60) days
following receipt of an undisputed invoice.


 


5.8          Late
Payments.


 


Any amount required
to be paid by a Party hereunder which is not paid on the date due shall bear interest, to the extent permitted by law, at (a) for
the first three (3) incidents, three percent (3%) above the thirty (30) day U.S. Dollar LIBOR rate effective for the date such
payment was due, as reported in the Wall Street Journal and (b) for all incidents after the first three (3) incidents, five percent
(5%) above the thirty (30) day U.S. Dollar LIBOR rate effective for the date such payment was due, as reported in the Wall Street
Journal. Such interest shall be computed on the basis of a year of three hundred sixty (360) days for the actual number of days
payment is delinquent.


 








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Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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5.9          Currency.


 


Any payments under
this Article 5 that are recorded in currencies other than the U.S. Dollar shall be converted into U.S. Dollars using the
exchange rate mechanism generally applied by Licensee or its applicable Affiliate or sublicensee in preparing its audited financial
statements for the applicable Calendar Quarter, provided that such mechanism is in compliance with Accounting Standards
and verifiable from publicly available information.


 


5.10        Method
of Payment.


 


All payments from Licensee
to Pfizer shall be made by wire transfer via immediately available funds in U.S. dollars to credit the bank account set forth on
Schedule J or such other bank account as designated by Pfizer in writing to Licensee at least thirty (30) days before payment is
due. Any payment which falls due on a date which is not a Business Day may be made on the next succeeding Business Day.


 


5.11        Taxes.


 


5.11.1 General.
It is understood and agreed between the Parties that any payments made under this Agreement are exclusive of any value added or
similar tax (“VAT”), which shall be added thereon as applicable. In the event any payments made by Licensee
to Pfizer pursuant to this Agreement become subject to withholding taxes under the laws or regulation of any jurisdiction, Licensee
shall deduct and withhold the amount of such taxes for the account of Pfizer to the extent required by Applicable Law and such
amounts payable to Pfizer shall be reduced by the amount of taxes deducted and withheld, which shall be treated as paid to Pfizer
in accordance with this Agreement. To the extent that Licensee is required to deduct and withhold taxes on any payments under this
Agreement, Licensee shall pay the amounts of such taxes to the proper Governmental Authority in a timely manner and promptly transmit
to the payee an official tax certificate or other evidence of such withholding sufficient to enable Pfizer to claim such payments
of taxes. Pfizer shall provide any tax forms to Licensee that may be reasonably necessary in order for Licensee not to withhold
tax or to withhold tax at a reduced rate under an applicable bilateral income tax treaty. Each Party shall provide the other with
reasonable assistance to enable the recovery, as permitted by Applicable Law, of withholding taxes, VAT, or similar obligations
resulting from payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding tax
or VAT.


 


5.11.2 Tax Actions.
Notwithstanding anything in this Agreement to the contrary, if an action, including but not limited to any assignment or sublicense
of its rights or obligations under this Agreement, or any failure to comply with Applicable Laws or filing or record retention
requirements (a “Tax Action”) by a Party leads to the imposition of withholding tax liability or VAT on the
other Party that would not have been imposed in the absence of a Tax Action or in an increase in such liability above the liability
that would have been imposed in the absence of such Tax Action, then (i) the sum payable by the Party that caused the Tax Action
(in respect of which such deduction or withholding is required to be made) shall be increased to the extent necessary to ensure
that the other Party receives a sum equal to the sum which it would have received had no Tax Action occurred and (ii) the sum payable
by the Party that caused a Tax Action (in respect of which such deduction or withholding is required to be made) shall be made
to the other Party after deduction of the amount required to be so deducted or withheld, which deducted or withheld amount shall
be remitted in accordance with Applicable Law. For the avoidance of doubt, a Party shall only be liable for increased payments
pursuant to this Section 5.11.2 to the extent such Party engaged in a Tax Action that created or increased a withholding
tax or VAT on the other Party.


 




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5.11.3 Cooperation.
The Parties agree to cooperate and produce on a timely basis any tax forms or reports, including IRS Forms W-9 and W-8BEN, reasonably
requested by the other Party in connection with any payment made by Licensee to Pfizer under this Agreement.


 


5.12        Royalty
Reconciliation.


 


On a Product-by-Product and country-by-country
basis, with respect to Net Sales of such Product in such country in the final Calendar Quarter of the Royalty Term for such Product
in such country, Licensee shall pay any royalties owed to Pfizer pursuant to Section 5.4, as adjusted by Section 5.5,
for such Net Sales (each, a “Final Royalty Payment”) within one hundred twenty (120) days (such one hundred
twenty (120) days inclusive of the sixty (60) days set forth in Section 5.4) after the end of the Royalty Term for such
Product in such country, along with a final written report setting forth Licensee’s final calculation of Net Sales of such
Product in such country during each of the final eight (8) Calendar Quarters of such Royalty Term (each, a “Final Royalty
Report”). If such Final Royalty Report contains any corrections to the Net Sales previously reported by Licensee in any
of such eight (8) Calendar Quarters then, to the extent that such corrections have not been previously addressed by Licensee or
Pfizer, (a) if such corrections have, taken together, increased the reported Net Sales of such Product in such country, Licensee
shall, simultaneously with providing such Final Royalty Report and Final Royalty Payment, pay to Pfizer the additional royalties
that are due for such additional Net Sales pursuant to Section 5.4, as adjusted by Section 5.5, and (b) if such corrections
have, taken together, decreased the reported Net Sales of such Product in such country, Licensee shall reduce such Final Royalty
Payment by an amount equal to the excess royalties paid by Licensee to Pfizer for such excess Net Sales.


 


6.          Records;
Audit Rights.


 


6.1          Relevant
Records.


 


Licensee shall maintain
accurate financial books and records created or received by Licensee pertaining to sale of the Products by Licensee, its Affiliates
or sublicensees or any Transaction Completion Payment (collectively, “Relevant Records”). Licensee shall maintain
the Relevant Records for the longer of: (a) the period of time required by Applicable Law, or (b) seven (7) years following the
date on which the relevant amounts were received or incurred.


 




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6.2           Audit
Request.


 


Pfizer shall have the
right during the Term and for twelve (12) months thereafter to engage, at its own expense, an independent auditor that is reasonably
acceptable to Licensee and subject to a reasonable and customary confidentiality agreement with Licensee, to examine the Relevant
Records from time-to-time, but no more frequently than once every twelve (12) months, as may be necessary to verify Licensee’s
compliance with the provisions of Article 5 or any other payments described in this Agreement. Such audit shall be requested
in writing at least ten (10) Business Days in advance, and shall be conducted during Licensee’s normal business hours, in
the location where such Relevant Records are normally kept, and otherwise in a manner that minimizes any interference to Licensee’s
business operations. No Relevant Record may be audited more than once nor more than seven (7) years following the date on which
the relevant amounts were received or incurred. Pfizer shall provide to Licensee a copy of each audit report promptly following
Pfizer’s receipt thereof.


 


6.3           Audit
Fees and Expenses.


 


Pfizer shall bear any
and all fees and expenses it may incur in connection with any such audit of the Relevant Records; provided, however, in
the event an audit reveals an underpayment by Licensee of more than [***] as to the period subject to the audit, Licensee shall
reimburse Pfizer for its reasonable and documented out-of-pocket costs and expenses of the audit within sixty (60) days after receiving
invoices therefor.


 


6.4           Payment
of Deficiency.


 


If any such audit establishes
that Licensee underpaid any amounts due to Pfizer under this Agreement, then Licensee shall pay Pfizer any such deficiency within
sixty (60) days after receipt of written notice thereof and the relevant audit report. For the avoidance of doubt, such underpayment
will be considered a late payment, subject to Section 5.8. If any audit, whether or not conducted by Pfizer, establishes
that Licensee overpaid any amounts due to Pfizer under this Agreement, then Licensee shall immediately offset all such excess payments
against any outstanding or future amounts payable by Licensee to Pfizer under this Agreement until Licensee has received full credit
for all such overpayments.


 


7.          Intellectual
Property Rights.


 


7.1           Pre-existing
IP.


 


Subject only to the
rights expressly granted to the other Party under this Agreement, each Party shall retain all rights, title and interests in and
to any Intellectual Property Rights that are owned by, or licensed or sublicensed to, such Party prior to or independent of this
Agreement.


 


7.2           Developed
IP.


 


Ownership of any Developed
IP shall be determined in accordance with Applicable Laws relating to inventorship set forth in U.S. patent laws. Each Party and
its Affiliates retains the sole right to prepare, prosecute, and maintain Patent Rights included within any Developed IP owned
by or licensed to such Party or its Affiliates; provided, however, that the Parties shall coordinate in good faith
with respect to the preparation, prosecution and maintenance of Patent Rights included within any Developed IP owned jointly by
Pfizer or any of its Affiliates, on the one hand, and Licensee or any of its Affiliates, on the other hand, and neither Party nor
any of its Affiliates may prepare, prosecute or maintain any such Patent Right without the prior written consent of the other Party.
Subject to the rights and licenses granted herein, each Party is entitled to practice jointly- owned Developed IP for all purposes
on a worldwide basis, and to grant licenses and similar rights under and to its rights in such jointly-owned Developed IP without
consent of and without a duty of accounting to the other Party. Each Party will grant and hereby does grant all permissions, consents
and waivers with respect to, and all licenses under, such jointly-owned Developed IP, throughout the world, necessary to provide
the other Party with such rights of use and exploitation of such jointly-owned Developed IP, and will execute documents as necessary
to accomplish the foregoing and as reasonably requested by the other Party.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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7.3          Inactive
Patents.


 


With respect to any
cases that are designated by Pfizer as “Inactive” in the column labeled “Status” in Schedule E (each,
an “Inactive Case”): (a) such Inactive Cases may or may not be still in force or, if lapsed, may or may not
be revivable, (b) notwithstanding anything herein to the contrary, Pfizer makes no representation or warranty with respect to the
continued existence, status, revivability, validity or enforceability of such Inactive Cases and (c) Pfizer shall have no obligation
to maintain or revive any such Inactive Case or expend any funds or substantial effort in connection therewith.


 


7.4          Patent
Prosecution of Licensed Patent Rights.


 


7.4.1 Patent Prosecution
and Maintenance. Subject to Pfizer’s rights set forth in Section 7.4.3 below, (a) until the earlier of (i) the
six (6) month anniversary of the Effective Date and (ii) such time as Licensee provides Pfizer written notice that it desires to
assume the activities under Section 7.4.1(b) (the “Initial Period”), Pfizer will continue to file, prosecute
(including in connection with any reexaminations, oppositions, inter partes reviews and the like) and maintain the Active
Cases in the Licensed Patent Rights in the Territory, in Pfizer’s name on behalf of Licensee and Licensee shall bear all
of Pfizer’s reasonable and documented out-of-pocket expenses with respect to such filing, prosecution and maintenance, and
(b) upon expiration of the Initial Period, (i) Licensee will control the filing, prosecuting (including in connection with any
reexaminations, oppositions, inter partes reviews and the like) and maintaining of the Licensed Patent Rights (including,
for avoidance of doubt, any Arising Patent Rights) in the Territory, in Pfizer’s name, at Licensee’s own cost and expense
using qualified patent counsel, foreign agents and annuity service providers as necessary, in each case reasonably acceptable to
Pfizer and (ii) Pfizer shall, and shall ensure that its patent counsel, foreign agents and annuity service providers promptly transfer
all documentation related to the Licensed Patent Rights to Licensee or its applicable designee(s). Following the Initial Period
and during the Term, Licensee will provide notice of any substitution of such counsel, foreign agents, or annuity service providers
within thirty (30) days after such substitution. During the Initial Period, Pfizer will (y) promptly provide Licensee with a copy
of all substantive communications relating to such Licensed Patent Rights that are received from any patent office or patent counsel
of record or foreign associate and (z) allow Licensee a reasonable opportunity and reasonable time to review and comment on any
proposed submissions to any patent office and implement any reasonable comments provided by Licensee to Pfizer. After the Initial
Period, (A) before each patent application or other submission is filed, Licensee will provide Pfizer a reasonable opportunity
to review and comment thereon and will reasonably consider any comments provided by Pfizer to Licensee, and (B) Licensee will keep
Pfizer reasonably informed of the status of the Licensed Patent Rights by timely providing Pfizer copies of significant communications
relating to such Licensed Patent Rights that are received from any patent office or patent counsel of record or foreign associate.


 




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7.4.2 Assistance.
As reasonably requested by Licensee in writing, Pfizer shall cooperate, at Licensee’s expense for Pfizer’s reasonable
and documented out-of-pocket expenses, (a) with Licensee’s activities in Section 7.4.1 and (b) in obtaining patent
term adjustment, patent term restoration (whether or not under the Drug Price Competition and Patent Term Restoration Act), supplementary
protection certificates, patent term extensions or any equivalent to the foregoing, with respect to the Licensed Patent Rights.
For clarity, Licensee shall have the exclusive right, but not the obligation, to seek, in Pfizer’s name if so required, or
require Pfizer to seek, any patent term adjustments, patent term restorations, patent term extensions, supplemental protection
certificates and the like in any country in the Territory in relation to the Licensed Patent Rights and Pfizer shall cooperate
in connection with all such activities.


 


7.4.3 Failure to Prosecute
or Maintain. In the event Licensee elects to forego filing, prosecution, or maintenance of any of the Licensed Patent Rights
in any country or region, Licensee shall notify Pfizer of such election at least forty-five (45) days prior to any filing or payment
due date, or any other due date that requires action (“Election Notice”). Upon receipt of an Election Notice,
Pfizer shall be entitled, upon written notice to Licensee, at its sole discretion and expense, to file or to continue the prosecution
or maintenance of such Patent Right in such country or region in Pfizer’s name using counsel of its own choice and at its
own expense, in which case the license granted in Section 2.1 with respect to such Patent Rights in such country or region
shall continue as a non-exclusive license, subject to Licensee’s obligation to pay Royalties in accordance with Section
5.4.


 


7.4.4 Liability.
To the extent Pfizer is obtaining, prosecuting or maintaining a Patent Right included in the Licensed Patent Rights, Pfizer, its
Affiliates, employees, agents or representatives, shall not be liable to Licensee in respect of any act, omission, default or neglect
on the part of Pfizer, or its Affiliates, employees, agents or representatives, in connection with such activities undertaken in
good faith.


 


7.4.5 Patent Prosecution
of Enabling Patent Rights. Pfizer retains the sole right to prepare, prosecute, and maintain the Enabling Patent Rights.


 


7.5          Listing
in Orange Book.


 


Licensee shall have
the right, in its sole discretion, to make all filings with Regulatory Authorities in the Territory for each Product in the FDA’s
Orange Book, and under any similar or equivalent laws in other countries or jurisdictions; provided, however, that
the Parties shall collaborate in good faith to determine whether any Enabling Patent Rights or Patent Rights included in the Pfizer
Developed IP are required to be included in any such filings.


 


8.          Infringement;
Misappropriation.


 


8.1           Notification.


 


Each Party will promptly
notify the other Party in writing of any (a) actual or threatened infringement, misappropriation or other violation by a Third
Party of any Licensed Technology in the Fields and in the Territory of which it becomes aware, including the filing of an Abbreviated
New Drug Application under Section 505(j) of the FD&C Act or an application under Section 505(b)(2) of the FD&C Act naming
a Product as a reference listed drug and including a certification under Section 505(j)(2)(A)(vii)(IV) or 505(b)(2)(A)(IV), respectively,
or (b) declaratory judgment action against, or any other action claiming invalidity or unenforceability of, any Licensed Patent
Right in the Territory, whether or not in connection with any infringement described in clause (a) (any of (a) or (b) constituting
a “Third Party Infringement”).


 




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8.2          Infringement
Action.


 


8.2.1 Right of First
Enforcement.


 


(a)          Licensee,
itself or through any of its Affiliates or sublicensees, shall have the first right (but not the obligation), at its own expense,
to control enforcement of the Licensed Technology against any Third Party Infringement within the scope of its exclusive license
(i.e., its license within the Fields) and may name Pfizer as a party for standing purposes. Pfizer shall cooperate with and join,
at Licensee’s request and expense, any such action and has the right to join any such action, including retaining separate
counsel, at Pfizer’s own expense. Prior to commencing any such action, Licensee shall consult with Pfizer and shall give
due consideration to Pfizer’s timely recommendations regarding the proposed action. Licensee shall give Pfizer timely notice
of any proposed settlement of any such action instituted by Licensee and shall not, without the prior written consent of Pfizer,
enter into any settlement that would: (i) adversely affect the validity, enforceability or scope of any of the Licensed Patent
Rights; (ii) give rise to liability of Pfizer or its Affiliates; (iii) admit non-infringement of any Licensed Patent Rights; or
(iv) otherwise impair Pfizer’s rights in any Licensed Technology or this Agreement.


 


(b)          If
Licensee does not, with respect to its first right of enforcement under Section 8.2.1(a), either (i) obtain agreement from
the alleged infringer to desist or (ii) confirm to Pfizer in writing, by the earlier of (A) sixty (60) days following Licensee’s
receipt of notice of the alleged infringement or (B) fifteen (15) days before the expiration date for filing an infringement action,
that Licensee, or any of its Affiliates or sublicensees, will initiate an infringement action, then Pfizer shall have the right,
at its sole discretion, to control such enforcement of the Licensed Technology at its sole expense.


 


8.2.2 Recoveries.
Any recoveries resulting from an action relating to a claim of Third Party Infringement shall first be applied to reimburse each
Party’s (and Licensee’s Affiliates’ and sublicensees’, as applicable) costs and expenses incurred in connection
therewith. Any remaining recoveries shall be retained by (or if received by Pfizer, paid to) Licensee; provided, however,
that (a) if Licensee’s negligence or intentional misconduct caused the applicable Third Party Infringement, then Pfizer shall
be entitled to receive [***] of such remaining recoveries and (b) otherwise, Pfizer shall be entitled to a royalty on such remaining
recoveries in accordance with Section 5.4 as if the amount of such remaining recoveries were Net Sales of Licensee in the
Calendar Year in which the recoveries were received by Licensee. If Licensee fails to institute an action or proceeding and Pfizer
exercises its right to prosecute such infringement pursuant to Section 8.2.1(b), any remaining recoveries shall be retained
by Pfizer.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




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9.          Confidentiality.


 


9.1           Definition.


 


“Confidential
Information” of a Party means the terms and provisions of this Agreement and all other proprietary information and data
of a financial, commercial or technical nature that the disclosing Party or any of its Affiliates has supplied or otherwise made
available to the other Party or its Affiliates in connection with this Agreement, which are disclosed in writing or, if disclosed
orally or visually, summarized in writing and provided to the receiving Party after disclosure. All Licensed Know-How and any other
Know-How generated before or during the Term by Pfizer or any of its Affiliates with respect to the Compound or a Product shall
be considered Pfizer’s and Licensee’s Confidential Information, with each of Pfizer and Licensee considered a disclosing
Party and a receiving Party with respect thereto, and Pfizer may not rely on clause (b) or (d) with respect thereto. Confidential
Information shall not include information that: (a) is, as of the Effective Date, or becomes, after the Effective Date, known to
the public or part of the public domain through no breach of this Agreement by the receiving Party or any of its Recipients; (b)
was known to, or was otherwise in the possession of, the receiving Party prior to the time of disclosure by the disclosing Party
to the receiving Party; (c) is disclosed to the receiving Party on a non-confidential basis by a Third Party who is entitled to
disclose it without breaching any confidentiality obligation to the disclosing Party; or (d) is independently developed by or on
behalf of the receiving Party or any of its Affiliates, as evidenced by its written records, without use or access to the Confidential
Information of the disclosing Party.


 


9.2           Obligations.


 


The receiving Party
may use the disclosing Party’s Confidential Information only to exercise the receiving Party’s rights under this Agreement
or perform the receiving Party’s obligations under this Agreement, or as necessary for an acquisition, investment or financing
of the receiving Party or any of its Affiliates. The receiving Party will protect all of the disclosing Party’s Confidential
Information against unauthorized disclosure to Third Parties with the same degree of care as the receiving Party uses for its own
similar information, but in no event less than a reasonable degree of care. The receiving Party may disclose the disclosing Party’s
Confidential Information to its Affiliates, and its and their respective directors, officers, employees, subcontractors, agents
and current and prospective sublicensees, permitted assignees, acquirers, financing sources, consultants, attorneys, accountants,
banks and investors (collectively, “Recipients”) who have a need to know such information for purposes related
to this Agreement, or, with respect to acquirers, the applicable acquisition, or, with respect to investors or financing sources,
the applicable investment or financing, provided such Recipients are bound by obligations of confidentiality and non-use of Confidential
Information at least as restrictive as those set forth in this Agreement. All obligations of confidentiality and non-use under
this Agreement shall survive expiration or termination of this Agreement for a period of five (5) years.


 


9.3           Exceptions.


 


9.3.1 Disclosure Required
by Law. The receiving Party may disclose the disclosing Party’s Confidential Information as required under Applicable
Laws, including any court order or other order of a Governmental Authority, provided that the receiving Party: (a) provides the
disclosing Party with prompt notice of such disclosure requirement if legally permitted; (b) affords the disclosing Party an opportunity
to oppose, limit or secure confidential treatment for such required disclosure; and (c) if the disclosing Party is unsuccessful
in its efforts pursuant to subsection (b), discloses only that portion of the disclosing Party’s Confidential Information
that the receiving Party is legally required to disclose as advised by the receiving Party’ s legal counsel.


 




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9.3.2 Disclosure to
Assignee of Payments. In the event that Pfizer wishes to assign, pledge or otherwise transfer to a Third Party its rights to
receive some or all of the Milestone Payments, Royalties or Transaction Completion Payment payable hereunder, Pfizer may, in connection
with any such proposed assignment, disclose to such Third Party such Confidential Information of Licensee that is reasonably relevant
to such assigned Milestone Payments, Royalties or Transaction Completion Payment, as applicable, provided that Pfizer shall hold
such Third Party to written obligations of confidentiality and non-use with terms and conditions at least as restrictive as those
set forth in this Agreement.


 


9.4           Right
to Injunctive Relief.


 


Each Party agrees that
breaches of this Article 9 may cause irreparable harm to the other Party and shall entitle such other Party, in addition
to any other remedies available to it (subject to the terms of this Agreement), the right to seek injunctive relief enjoining such
action.


 


9.5           Ongoing
Obligation for Confidentiality.


 


Upon expiration or
termination of this Agreement, the receiving Party shall, and shall cause its Recipients to, destroy or return (as requested by
the disclosing Party) any Confidential Information of the disclosing Party, except that the receiving Party (a) may retain a single
copy of the disclosing Party’ s Confidential Information for the sole purpose of (i) ascertaining its rights and responsibilities
in respect of such information and (ii) exercising its rights that expressly survive the expiration or termination of this Agreement,
and (b) shall not be required to destroy any computer files stored securely by the receiving Party that are created by automatic
system back up.


 


10.         Representations,
Warranties and Covenants.


 


10.1        Representations
and Warranties by Each Party.


 


Each Party represents
and warrants to the other Party as of the Effective Date that:


 


10.1.1 it is a corporation
duly organized, validly existing, and in good standing under the laws of its jurisdiction of formation;


 


10.1.2 it has full corporate
power and authority to execute, deliver, and perform under this Agreement, and has taken all corporate action required by Applicable
Law and its organizational documents to authorize the execution and delivery of this Agreement and the consummation of the transactions
contemplated by this Agreement;


 


10.1.3 this Agreement
constitutes a valid and binding agreement enforceable against it in accordance with its terms;


 




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10.1.4 all consents,
approvals and authorizations from all Governmental Authorities or other Third Parties required to be obtained by such Party in
connection with this Agreement have been obtained; and


 


10.1.5 the execution
and delivery of this Agreement and all other instruments and documents required to be executed pursuant to this Agreement, and
the consummation of the transactions contemplated hereby do not and shall not: (a) conflict with or result in a breach of any provision
of its organizational documents; (b) result in a breach of any agreement to which it is a party that would impair the performance
of its obligations hereunder; or (c) violate any Applicable Law.


 


10.2        Representations
and Warranties by Pfizer.


 


With the exception
of the claims described in Schedule G, Pfizer represents and warrants to Licensee as of the Effective Date that:


 


10.2.1 Pfizer or its
Affiliates own all of the Licensed Patent Rights (with respect to each Inactive Case listed on Schedule E, solely to the
extent such Inactive Case is determined by Licensee to be in force as of the Effective Date). All Active Cases in the Licensed
Patent Rights in the Major Markets have been assigned to Pfizer or its Affiliates and assignment documents with respect to the
U.S. Patent Rights have been executed and recorded in the relevant U.S. patent offices; as used herein, “Active Cases”
means cases that are not designated by Pfizer as “Inactive” in the column labeled “Status” in Schedule
E;


 


10.2.2 to Pfizer’s
Knowledge, Pfizer or its Affiliates own all of the Licensed Know-how set forth on Schedule C;


 


10.2.3 to Pfizer’s
Knowledge, Pfizer has the right to grant the licenses and other rights granted to Licensee under this Agreement with respect to
the Licensed Patent Rights (with respect to any Inactive Case listed on Schedule E, solely to the extent such Inactive Case
is determined by Licensee to be in force as of the Effective Date) and to the Know-How listed in Schedule C or required
to be transferred by Pfizer to Licensee in accordance with Schedule D, including all applicable rights of its Affiliates
in such Intellectual Property Rights, in each case free and clear of any rights of any Third Party that would be in conflict with
the licenses and other rights granted to Licensee under this Agreement;


 


10.2.4 to Pfizer’s
Knowledge, there is no ongoing, or threatened (in writing to Pfizer), litigation, opposition, reexamination, interference, reissue,
revocation, nullification, post-grant review, nullity action or inter partes review involving any of the Active Cases in
the Licensed Patent Rights in the Major Markets;


 


10.2.5 to Pfizer’s
Knowledge, the Licensed Know-How, Licensed Patent Rights, Enabling Know-How and Enabling Patent Rights comprise all Know-How and
Patent Rights owned by or licensed to Pfizer or any of its Affiliates that are necessary for Licensee to Exploit the Compound,
and each Product, in the form in which it existed as of the Effective Date, in each Major Market, in the same manner that Pfizer
Exploited such Compound or such Product prior to the Effective Date in such Major Market;


 




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10.2.6 to Pfizer’s
Knowledge, there is no claim pending, or threatened (in writing to Pfizer), against Pfizer alleging that the Manufacture of the
Compound in the Fields, or Commercialization of the Compound in Field 1, in the Territory infringes or misappropriates any Know-How
or Patent Rights of any Third Party;


 


10.2.7 to Pfizer’s
Knowledge, there is no claim pending or threatened by Pfizer alleging that a Third Party is or was infringing, misappropriating
or otherwise violating any of the Licensed Patent Rights in the Fields in any country within the Territory;


 


10.2.8 to Pfizer’s
Knowledge, no Third Party has challenged the extent, validity or enforceability of any of the Licensed Patent Rights in any Major
Market;


 


10.2.9 to Pfizer’s
Knowledge, other than (a) agreements that have been terminated or have expired by their terms, in each case prior to the Effective
Date and (b) materials transfer agreements and compound transfer agreements (collectively, the “Terminated Agreements
and MTAs”), neither Pfizer nor any of its Affiliates is a party to any agreement with a Third Party as of the Effective
Date that would limit any license right granted to Licensee or its Affiliates under this Agreement, in each case, that would, but
for such agreement, be included in the rights licensed to Licensee and its Affiliates pursuant to this Agreement;


 


10.2.10 to Pfizer’s
Knowledge, all Compound transferred from Pfizer to Licensee that are set forth in Schedule H were, as of the date of such
manufacture, manufactured in accordance with GMP;


 


10.2.11 to Pfizer’s
Knowledge, each Regulatory Filing filed by Pfizer with respect to the Compound or any Product prior to the Effective Date was true,
complete and accurate in all material respects and timely filed;


 


10.2.12 to Pfizer’s
Knowledge, Pfizer and its Affiliates have complied with all Applicable Laws with respect to the Exploitation of the Compound prior
to the Effective Date, except to the extent that failure to so comply would not materially and adversely affect the Exploitation
of the Compound or any Product by or on behalf of Licensee;


 


10.2.13 to Pfizer’s
Knowledge, Pfizer and its Affiliates have not received any written notice that indicates that (a) any of the Regulatory Filings
are not in good standing with the relevant Regulatory Authorities or (b) any “clinical hold” or similar regulatory
action is in effect with respect to the Compound or any Product; and


 


10.2.14 neither Pfizer
nor, to its Knowledge, any of its members, officers, directors, employees, independent contractors, consultants, suppliers, agents
or clinical investigators who performed Compound- or Product-related work on behalf of Pfizer: (a) has been charged with or convicted
of any crime relating to the delivery of an item or service under any federal health care program, (b) is or has been debarred
under 21 U.S.C. §335a, (c) is or has been debarred, excluded or suspended from participation in any federal health care program,
(d) is or has been debarred by any other federal or international agency, or (e) has engaged in any conduct that has resulted,
or would reasonably be expected to result, in debarment under applicable laws, including 21 U.S.C. §335a, or exclusion from
participation in government programs under 42 U.S.C. § 1320a-7 or another applicable law. No actions that would reasonably
be expected to result in such a debarment or exclusion are pending or, to Pfizer’s Knowledge, threatened against Pfizer or
any such officers, directors, employees, independent contractors, consultants, suppliers, agents or clinical investigators, and,
to Pfizer’s Knowledge, there are no facts that would reasonably give rise to such an action.


 




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10.3        Representations,
Warranties and Covenants by Licensee.


 


10.3.1 Licensee covenants
to Pfizer that it shall comply with all Applicable Law with respect to the performance of its obligations hereunder.


 


10.3.2 Licensee covenants
to Pfizer that it will not use any units of Compound transferred by Pfizer under Article 3 in humans, except and to the
extent that Licensee subsequently processes such units of Compound in accordance with Applicable Law, and provided that such units
of Compound have met the requirements of any Regulatory Authority; and


 


10.3.3 Licensee covenants
to Pfizer that Licensee shall use its Commercially Reasonable Efforts to execute the Development Plan on the timeline set forth
therein; provided, however, that each Party acknowledges and agrees that the Development Plan and timelines therein
may be updated pursuant to Section 4.6 and that the initial version of the Development Plan (including the timeline therein)
does not reflect certain vital information that is not yet available, including input from the FDA, but that each updated Development
Plan shall include the same amount of detail as in the draft of the Development Plan set forth in Schedule F as of the Effective
Date.


 


10.4         Representations,
Warranties and Covenants related to Compliance Laws.


 


Without limiting the
generality of Section 10.3.1, Licensee shall comply with the U.S. Foreign Corrupt Practices Act and any other applicable
anti-bribery or anti-corruption laws (“Compliance Laws”). Licensee represents and warrants that neither Licensee,
nor its Affiliates, nor, to Licensee’s knowledge, any director, officer, employee, consultant, agent or representative or
other person acting on its behalf has taken or will take any action, directly or indirectly, to pay, offer, promise or authorize
the payment, or giving of anything of value to any Government Official, or to any person, and has not accepted and will not accept
a payment for any item of value: (a) for the purpose of (i) influencing any act or decision of such Government Official(s) in their
official capacity, including the failure to perform an official function, in order to assist Licensee or its Affiliates or any
beneficiary of Licensee in obtaining or retaining business, or directing business to any third party, (ii) securing an improper
advantage, (iii) inducing such Government Official(s) to use their influence to affect or influence any act or decision of a government
entity in order to assist Licensee, its Affiliates or any beneficiary of Licensee in obtaining or retaining business, or directing
business to any third party, or (iv) providing an unlawful personal gain or benefit, of financial or other value, to such Government
Official(s); or (b) otherwise for the benefit of Licensee, or any of its Affiliates, in violation of any federal, state, local,
municipal, foreign, international, multinational or other administrative law. As used herein, “Government Official”
means: (A) any elected or appointed government official (e.g., a member of a ministry of health), (B) any employee or person acting
for or on behalf of a government official, agency, or enterprise performing a governmental function, (C) any political party officer,
employee, or person acting for or on behalf of a political party or candidate for public office, (D) an employee or person acting
for or on behalf of a public international organization, or (E) any person otherwise categorized as a government official under
local law. As used in this Section 10.4, “government” is meant to include all levels and subdivisions
of non-U.S. governments (i.e., local, regional, or national and administrative, legislative, or executive).


 




    	38



     


    

 


10.5         No
Action Required Which Would Violate Law.


 


In no event shall either
Party be obligated under this Agreement to take any action or omit to take any action that such Party believes, in good faith,
would cause such Party to violate any Applicable Law, including the Compliance Laws.


 


10.6         No
Other Warranties.


 


EXCEPT AS EXPRESSLY STATED IN THIS ARTICLE
10, NEITHER PARTY MAKES ANY REPRESENTATIONS OR EXTENDS ANY WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, STATUTORY OR
OTHERWISE, INCLUDING BUT NOT LIMITED TO WARRANTIES OF TITLE, NON-INFRINGEMENT, VALIDITY, ENFORCEABILITY, MERCHANTABILITY AND FITNESS
FOR A PARTICULAR PURPOSE. EXCEPT AS EXPRESSLY STATED IN THIS ARTICLE 10, ANY INFORMATION OR MATERIALS PROVIDED BY PFIZER
OR ITS AFFILIATES IS MADE AVAILABLE ON AN “AS IS” BASIS WITHOUT WARRANTY WITH RESPECT TO COMPLETENESS, COMPLIANCE WITH
REGULATORY STANDARDS OR REGULATIONS OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER KIND OF WARRANTY WHETHER EXPRESS OR IMPLIED.


 


11.         Indemnification.


 


11.1        Indemnification
by Licensee.


 


Licensee and SpringWorks
agree to indemnify, hold harmless and defend Pfizer and its Affiliates, and their respective officers, directors, employees, contractors,
agents and assigns (collectively, “Pfizer Indemnitees”), from and against any Third Party’s Claims to
the extent arising or resulting from (a) the Exploitation or any other use of a Compound or Product by Licensee, its Affiliates,
subcontractors or sublicensees, (b) the negligence, recklessness or wrongful intentional acts or omissions of Licensee, its Affiliates,
subcontractors or sublicensees under this Agreement, (c) breach by Licensee of any representation, warranty or covenant as set
forth in this Agreement, or (d) breach by Licensee of the scope of the license set forth in Section 2.1, except, in
each instance, to the extent that such Claim arose or resulted from the gross negligence or willful misconduct by any Pfizer Indemnitee;
provided, however, that, if SpringWorks ceases to be Licensee’s Parent and it has assigned its obligations
under this Article 11 to the Third Party involved in a Change of Control of Licensee or one of such Third Party’s
Affiliates (mutatis mutandis), then SpringWorks shall no longer have any obligations under this Article 11. As used
herein, “Claims” means collectively, any and all demands, claims, actions and proceedings (whether criminal
or civil, in contract, tort or otherwise) for losses, damages, liabilities, costs and expenses (including reasonable attorneys’
fees sought by the relevant Third Party in connection with such demand, claim, action or proceeding or incurred by the relevant
Indemnitee).


 




    	39



     


    

 


11.2         Indemnification
by Pfizer.


 


Pfizer agrees to indemnify,
hold harmless and defend Licensee and its Affiliates, and their respective officers, directors, employees, contractors, agents
and assigns (collectively, “Licensee Indemnitees”), from and against any Third Party’s Claims to the extent
arising or resulting from


 


(a)          product
liability arising from any Development, Manufacture or use of the Compound or Products by or on behalf of Pfizer or its Affiliates,
subcontractors or licensees prior to the Effective Date, (b) the Development, Manufacture, Commercialization or use of the Compound
or any Product by Pfizer or its Affiliates, subcontractors, assignors or licensees (other than Licensee and its Affiliates and
sublicensees) (i) in accordance with Pfizer’s retained rights in Section 2.3 or (ii) after the expiration or termination
of this Agreement to the extent such Claim arose after the effective date of such termination or expiration, (c) the negligence,
recklessness or wrongful intentional acts or omissions of Pfizer or its Affiliates (other than Licensee and its Affiliates and
sublicensees) under this Agreement, (d) breach by Pfizer of any representation, warranty or covenant as set forth in this Agreement,
(e) the Terminated Agreements and MTAs to the extent that any of the Terminated Agreements and MTAs limit any license right granted
to Licensee or its Affiliates under this Agreement, or (f) any breach by Pfizer of any agreement assigned by Licensee to Pfizer
in accordance with Section 13.5.2(c)(v) or 13.5.2(c)(vi), to the extent such breach first arose after the agreement
was assigned to Pfizer and was not due to Pfizer’s (or its Affiliate’s) acts or omissions, except, in each instance,
to the extent that such Claim arose or resulted from the gross negligence or willful misconduct by any Licensee Indemnitee.


 


11.3         Indemnification
Procedure.


 


In connection with
any Claim for which a Pfizer Indemnitee or a Licensee Indemnitee (the relevant “Indemnitee”) seeks indemnification
from Licensee or SpringWorks or Pfizer, respectively, (the “Indemnitor”) pursuant to this Agreement, Pfizer
or Licensee, respectively, shall: (a) give the Indemnitor prompt written notice of the Claim; provided, however, that failure
to provide such notice shall not relieve the Indemnitor from its liability or obligation hereunder, except to the extent of any
material prejudice as a direct result of such failure; (b) cooperate with the Indemnitor, at the Indemnitor’s request and
expense, in connection with the defense and settlement of the Claim; and (c) permit the Indemnitor to control the defense and settlement
of the Claim; provided, however, that the Indemnitor may not settle the Claim without Pfizer’s or Licensee’s,
respectively, prior written consent, which shall not be unreasonably withheld or delayed, in the event that such settlement materially
adversely impacts any relevant Indemnitee’s rights or obligations. Further, Pfizer or Licensee, respectively, shall have
the right to participate (but not control) and be represented in any suit or action by advisory counsel of its selection and at
its own expense. The Indemnitor shall not have any indemnity obligation with respect to any claim settled by an Indemnitee without
the Indemnitor’s prior written consent, such consent not to be unreasonably withheld or delayed.


 




    	40



     


    

 


12.         Limitation
of Liability.


 


12.1         Consequential
Damages Waiver.


 


EXCEPT FOR A BREACH OF ARTICLE 9
OR OBLIGATIONS ARISING UNDER ARTICLE 11 OR PFIZER’S BREACH OF THE EXCLUSIVE LICENSE GRANTED TO LICENSEE PURSUANT TO
SECTION 2.1, NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY FOR ANY INDIRECT, CONSEQUENTIAL, SPECIAL, EXEMPLARY OR PUNITIVE
DAMAGES, INCLUDING DAMAGES FOR LOST PROFITS OR LOST REVENUES REGARDLESS OF WHETHER IT HAS BEEN INFORMED OF THE POSSIBILITY OR LIKELIHOOD
OF SUCH DAMAGES OR THE TYPE OF CLAIM, CONTRACT OR TORT (INCLUDING NEGLIGENCE).


 


12.2         Liability
Cap.


 


IN NO EVENT SHALL PFIZER’S AGGREGATE
LIABILITY FOR DAMAGES IN CONNECTION WITH ANY OR ALL OF THE LICENSE AGREEMENTS EXCEED THE PFIZER CAP IN EFFECT AT THE TIME OF SUCH
CLAIM FOR DAMAGES, REGARDLESS OF WHETHER PFIZER HAS BEEN INFORMED OF THE POSSIBILITY OR LIKELIHOOD OF SUCH DAMAGES OR THE TYPE
OF CLAIM, CONTRACT OR TORT (INCLUDING NEGLIGENCE); PROVIDED, HOWEVER, THAT NOTHING HEREIN SHALL LIMIT PFIZER’S
LIABILITY FOR DAMAGES RESULTING FROM ANY FRAUD OF PFIZER.


 


“Pfizer
Cap” means an amount equal to (a) [***] U.S. Dollars ($[***]) plus (b) [***] U.S. Dollars ($[***]) plus (c) [***]
U.S. Dollars ($[***]); provided, however, that (i) if the event described in clause (b) of this Section 12.2
has occurred and thereafter [***], then the Pfizer Cap applicable at the time of such termination shall immediately be
decreased by [***] U.S. Dollars ($[***]) and/or (ii) if the event described in clause (c) of this Section 12.2 has
occurred and thereafter [***], then the Pfizer Cap applicable at the time of such termination shall immediately be decreased
by [***] U.S. Dollars ($[***]).


 


13.         Term;
Termination.


 


13.1         Term.


 


The term of this Agreement
(“Term”) shall commence as of the Effective Date and shall expire upon the last-to-expire Royalty Term, unless
earlier terminated as provided herein. Upon expiration of the Royalty Term with respect to a Product in a country, the licenses
granted to Licensee under this Agreement shall convert to perpetual, irrevocable, non-exclusive, fully paid up, non-royalty-bearing
licenses with respect to such Product in such country and no other amounts shall be due by Licensee with respect to such Product
in such country hereunder.


 


13.2         Termination
for Cause.


 


Each Party shall have
the right, without prejudice to any other remedies available to it at law or in equity, to terminate this Agreement in the event
such other Party materially breaches any of its obligations hereunder and fails to cure such breach within sixty (60) days of receiving
a notice describing such breach; provided, however, if such breach is capable of being cured, but cannot be cured within
such sixty (60) day period, and the breaching Party initiates actions to cure such breach within such period and thereafter diligently
pursues such actions, the breaching Party shall have such additional period as is reasonable to cure such breach, but in no event
will such additional period exceed sixty (60) days. All timeframes in this Section 13.2 shall be tolled until the resolution
pursuant to Article 16 of any good faith dispute over the existence or nature of the breach, or over the adequacy of the
cure thereof. Any termination by a Party under this Section 13.2 shall be without prejudice to any damages or other legal
or equitable remedies to which it may be entitled from the other Party.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	41



     


    

 


13.3        Termination
for a Bankruptcy Event.


 


Pfizer shall have the
right to terminate this Agreement in the event of a Bankruptcy Event with respect to Licensee. “Bankruptcy Event”
means the occurrence of any of the following: (a) the institution of any bankruptcy, receivership, insolvency, reorganization or
other similar proceedings by or against Licensee under any bankruptcy, insolvency, or other similar law now or hereinafter in effect,
including any section or chapter of the United States Bankruptcy Code, as amended or under any similar laws or statutes of the
United States or any state thereof (any of the laws described in this clause (a), the “Bankruptcy Code”), where
such proceedings have not been dismissed or discharged within ninety (90) days after they are instituted, (b) Licensee assigns
all or a substantial portion of its assets for the benefit of creditors, (c) a receiver or custodian is appointed for Licensee’s
business and remains so appointed for at least ninety (90) days, (d) a substantial portion of Licensee’s business is subject
to attachment or similar process for at least ninety (90) days, or (e) anything analogous to any of the events described in the
foregoing clauses (a) through (d) occurs under the laws of any applicable jurisdiction.


 


13.4        Termination
for Convenience.


 


At any time on or after
the first (1st) anniversary of the Effective Date, Licensee shall have the right to terminate this Agreement for convenience upon
thirty (30) days’ prior written notice to Pfizer.


 


13.5        Effects
of Termination.


 


13.5.1 Termination
by Licensee for Cause. If Licensee has the right to terminate this Agreement pursuant to Section 13.2 or Section
17.4, then Licensee may, by written notice to Pfizer sent on, before, or reasonably after the applicable cure period, elect
to continue this Agreement or terminate this Agreement, with the consequences set forth in either Section 13.5.1(a) or Section
13.5.1(b), as applicable:


 


(a)          Continuation.
In the event that Licensee elects to continue this Agreement, then all provisions of this Agreement shall remain in full force
and effect without change.


 


(b)          Termination.
In the event that Licensee terminates this Agreement pursuant to Section 13.2 or Section 17.4, the following shall
apply:


 


(i)          Rights
and Obligations. Except as otherwise provided herein, all rights and obligations of each Party hereunder shall cease, including,
subject to Section 13.5.1(b)(ii), the licenses granted to Licensee pursuant to Section 2.1; and


 


(ii)         Licensee
Inventory. Licensee shall have the right to sell its remaining inventory of any Product so long as Licensee has fully paid,
and continues to pay when due, all Royalties, Milestone Payments, and Transaction Completion Payments, as applicable, and Licensee
is otherwise not in material breach of this Agreement.


 




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13.5.2 Termination by
Pfizer for Cause, Bankruptcy Event; Termination by Licensee for Convenience. In the event that Pfizer terminates this Agreement
pursuant to Section 13.2, Section 13.3 or Section 17.4, or Licensee terminates this Agreement pursuant to Section 13.4, the following
shall apply:


 


(a)          Rights
and Obligations. Except as otherwise provided herein, all rights and obligations of each Party hereunder shall cease; and


 


(b)          Licenses.


 


(i)          Pfizer
shall have a perpetual, irrevocable, worldwide, fully- paid up, royalty-free, exclusive right and license, with the right to grant
sublicenses, under the Developed IP Controlled by Licensee, as it exists as of the effective date of termination, to use, Develop,
Commercialize and Manufacture the Compound and Products, excluding Continuation Products.


 


(ii)         If
requested by Pfizer during the notice period provided in Section 13.2 or Section 13.4, or at the time of termination
pursuant to Section 13.3 or Section 17.4, (the “License Request”) Pfizer shall have a worldwide,
royalty-bearing, exclusive right and license, with the right to grant sublicenses, under the Developed IP Controlled by Licensee,
as it exists as of the effective date of termination, to use, Develop, Commercialize and Manufacture Continuation Products. From
and after such termination, in the event Pfizer timely provided the License Request, to the extent that Pfizer or any of its Affiliates
or sublicensees further Develops or Commercializes any Continuation Product in the Field for which the Development Stage was achieved
for such Continuation Product pursuant to the table below,


 


Pfizer shall pay Licensee the royalties
on Net Sales, mutatis mutandis, with respect to such Continuation Product at the applicable rate set forth in the following
table, determined based on a Continuation Product-by-Continuation Product basis:


 


	Development Stage of Continuation Product as of Effective Date of Termination	 	 	Royalty Rate	 
	Full enrollment has been achieved with respect to the first Phase III Clinical Trial of the Continuation Product	 	 	[***]	%
	An NDA has been filed with respect to the Continuation Product	 	 	[***]	%
	A First Commercial Sale has occurred with respect to the Continuation Product	 	 	[***]	%



 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	43



     


    

 


For avoidance of doubt, the royalties set
forth above in this Section 13.5.2(b)(ii) are not incremental to the royalties set forth in Section 5.4, and the
royalties set forth above in this Section 13.5.2(b)(ii) shall only apply to the Continuation Product(s) and no other product
or Product that Pfizer may Develop, nor shall the royalties apply to Products that are outside of the Field of the Development


 


Stage achieved by such
Continuation Product. For example, if an NDA had been filed for a Continuation Product in Field 1, but no Development Stage
was achieved for any Products in Field 2, then [***], but royalties of [***] would be due to Licensee on Net Sales of such
Products in Field 1. Such royalties shall be paid for the Continuation Product Royalty Term in accordance with the provisions
of Sections 5.4, 5.5, 5.8, 5.9, 5.10 (to a bank account provided by Licensee) and 5.11, mutatis
mutandis.


 


(c)          Transition.
If Pfizer timely makes a License Request, then, within a reasonable period of time, at Pfizer’s sole option, the Parties
shall negotiate in good faith a transition plan on commercially reasonable terms that will include, at a minimum, a plan for accomplishing
the activities described in this Section 13.5.2(c).


 


(i)          Continued
Development. At Pfizer’s request, Licensee shall continue on-going Development of the Products in the Fields for a mutually
agreed-upon period following termination of this Agreement, which period shall not be less than three (3) months unless otherwise
agreed to by the Parties; provided, however, that if Pfizer chooses not to continue a Clinical Trial initiated by
Licensee or if, for the safety of any subject, any Clinical Trial with respect to a Product should not be continued, Licensee shall
be solely responsible for the cost of winding down such trial, including any costs arising from compliance with any ethical or
other requirements imposed by an applicable Regulatory Authority.


 


(ii)         Technology
Transfer. At Pfizer’s request, Licensee shall make available to Pfizer all currently available records and data which
exist and are Controlled by Licensee as of the effective date of termination and are necessary or reasonably useful for Pfizer
to continue using, Developing, Commercializing and Manufacturing the Products.


 


(iii)        Regulatory
Matters. At Pfizer’s request, Licensee shall transfer and assign to Pfizer (or its designee) all Regulatory Approvals
(including pricing approvals) and Regulatory Filings held by Licensee with respect to the Products, provided that if such transfer
and assignment is not permitted by the applicable Regulatory Authority, Licensee shall permit Pfizer to cross-reference and rely
upon such Regulatory Approvals (including pricing approvals) and Regulatory Filings for the purpose of using, Developing, Commercializing
and Manufacturing the Products. Licensee shall make available to Pfizer copies of all regulatory documentation and records related
to the Products, including information contained in the regulatory and safety databases. The Parties shall cooperate to ensure
the prompt transition of regulatory responsibilities for the Products from Licensee to Pfizer.


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	44



     


    

 


(iv)        Trademarks.
(A) Pfizer shall have an exclusive, fully paid- up, royalty-free, worldwide, transferable, sublicensable, perpetual and irrevocable
license to use the trademarks Controlled by Licensee and associated with the Compound or Products solely for the purpose of using,
Developing, Commercializing and Manufacturing the Products; (B) Pfizer shall also have a non-exclusive, fully paid-up, royalty-free,
worldwide, transferable, sublicensable, perpetual and irrevocable license to use any trademarks or part thereof that use or incorporate
Licensee or its Affiliate’s names solely to the extent required by a Regulatory Authority to be displayed to indicate manufacturing
source or other identifying information with respect to the inventory described in clause (v) hereof; and (C) Pfizer and its Affiliates
and sublicensees shall comply with Licensee’s reasonable trademark guidelines and quality control procedures negotiated between
the Parties in good faith with respect to each of (A) and (B).


 


(v)         Inventory
and Supply. At Pfizer’s request and expense, Licensee shall transfer to Pfizer (or its designee) all Products, and all
components and in-process inventory with respect thereto, produced or held by Licensee as of the effective date of termination
with respect to the Manufacture of Products, except as necessary to perform its obligations under Section 13.5.2(c)(i).
At Pfizer’s request and expense, (A) if Licensee has sublicensed to a Third Party CMO the right to Manufacture the Products,
Licensee shall, to the extent permitted by the applicable sublicense agreement, promptly assign such sublicense to Pfizer; provided,
however, that (A) in no event shall Licensee be required to pay any fee in order to assign any contract under this Section
13.5.2(c)(v); and (B) if Licensee has not sublicensed the right to Manufacture the Products, Licensee shall continue to Manufacture
or have Manufactured the Products for a period of not less than twelve (12) months, including, at Pfizer’s request, a reasonable
stock build. Pfizer shall pay to Licensee the actual cost of Manufacturing associated with inventory and Products received by Pfizer
pursuant to this Section 13.5.2(c)(v), plus ten percent (10%).


 


(vi)        Third
Party Agreements. At Pfizer’s request, to the extent Licensee is able to do so, Licensee shall assign to Pfizer (or its
designee) any agreements with Third Parties with respect to the Development, Commercialization and Manufacture of the Products;
provided, however, that in no event shall Licensee be required to pay any fee in order to assign any contract under
this Section 13.5.2(c)(vi). With respect to Third Party agreements that Licensee is not able to assign to Pfizer, Licensee
shall cooperate to give Pfizer the benefit of such contracts for a reasonable transitional period.


 


(d)          Licensee
Inventory. In the event that Licensee terminates this Agreement pursuant to Section 13.4 and Pfizer elects not to initiate
transition activities pursuant to Section 13.5.2(c), Licensee shall have the right to sell its remaining inventory of Products
so long as Licensee has fully paid, and continues to pay when due, all Royalties, Milestone Payments, or Transaction Completion
Payments owed to Pfizer, and Licensee is otherwise not in material breach of this Agreement.


 


13.6         Survival.


 


Expiration or termination
of this Agreement shall not relieve the Parties of any obligation accruing hereunder prior to such expiration or termination. Without
limiting the foregoing, the provisions of Articles 1, 6, 9, 11, 12, 15, 16 and
17 and Sections 2.4, 2.5, 2.7, 5.12, 7.1, 7.2, 10.5, 10.6, 13.1,
13.5 and 13.6 shall survive expiration or termination of this Agreement.


 




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14.         Publicity;
Publications.


 


14.1         Use
of Names.


 


Subject to Pfizer’s
rights pursuant to Section 13.5.2(c)(iv), and except as required by Applicable Law or permitted under any other agreement
between Licensee or any of its Affiliates or investors, on the one hand, and Pfizer or any of its Affiliates, on the other hand,
neither Party (nor any of its Affiliates or agents) shall use the registered or unregistered trademarks, service marks, trade dress,
trade names, logos, insignia, domain names, symbols or designs of the other Party or its Affiliates in any press release, publication
or other form of promotional disclosure without the prior written consent of the other Party in each instance; provided,
however, that Licensee, and any of its Affiliates or sublicensees, may state publicly that Licensee has received, or been
sublicensed under, a license from Pfizer to Exploit the Compound and Products.


 


14.2         Press
Releases.


 


The Parties acknowledge
that one or both Parties, either singly or jointly, may desire to publish one or more press releases relating to this Agreement,
the rights granted hereunder, and developments made thereto. However, each Party agrees not to issue any press release or other
public statement, whether written, electronic, oral or otherwise, disclosing the terms of this Agreement without the prior written
consent of the other Party, such consent not to be unreasonably withheld or delayed. Neither Party will be prevented from (a) complying
with any duty of disclosure it may have pursuant to Applicable Law or the rules of any recognized stock exchange, so long as the
disclosing Party provides the other Party at least seven (7) Business Days prior written notice to the extent practicable and only
discloses information to the extent required by Applicable Law or the rules of any recognized stock exchange, or (b) making any
disclosure permitted under any other agreement between Licensee or any of its Affiliates or investors, on the one hand, and Pfizer
or any of its Affiliates, on the other hand.


 


14.3         Publications.


 


During the Term, each
Party shall submit to the other Party for review and approval any proposed academic, scientific or medical publication or public
presentation that contains the other Party’s Confidential Information. Such review and approval will be conducted for the
purposes of preserving the value of the Licensed Technology and Licensee’s commercial interests in the Compound and Products
and determining whether any portion of the proposed publication or presentation containing such other Party’s Confidential
Information should be modified or deleted. Written copies of such proposed publication or presentation required to be submitted
hereunder shall be submitted to the reviewing Party no later than thirty (30) days before submission for publication or presentation
(the “Review Period”). The reviewing Party shall provide its comments with respect to such publications and
presentations within twenty (20) days of its receipt of such written copy, which comments the other Party shall reasonably consider.
The Review Period may be extended for an additional thirty (30) days in the event the reviewing Party can, within twenty (20) days
of receipt of the written copy, demonstrate reasonable need for such extension, including for the preparation and filing of patent
applications. Each Party will comply with standard academic practice regarding authorship of scientific publications and recognition
of contribution of other parties in any publication governed by this Section 14.3, including International Committee of
Medical Journal Editors standards regarding authorship and contributions.


 




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15.         Licensee
Insurance.


 


15.1         Insurance
Requirements.


 


As soon as practicable
following the Effective Date (and in any event within twenty (20) Business Days after the Effective Date), Licensee will obtain
and thereafter during the Term will maintain until the later of: (a) three (3) years after termination or expiration of this Agreement,
or


 


(a)          the
date that all statutes of limitation covering claims or suits that may be instituted for personal injury based on the sale or use
of the Products by Licensee or any of its Affiliates or sublicensees have expired, commercial general liability insurance from
a minimum “A-” AM Best rated insurance company, including contractual liability and product liability or clinical trials,
if applicable, with coverage limits of not less than five (5) million U.S. Dollars per occurrence and five (5) million U.S. Dollars
in the aggregate. Licensee has the right to provide the total limits required by any combination of primary and umbrella/excess
coverage. The minimum level of insurance set forth herein shall not be construed to create a limit on Licensee’s liability
hereunder. Such policies shall name Pfizer and its Affiliates as additional insured (usually for US, Canada, and Puerto Rico exposures)
or indemnify Pfizer and its Affiliates, as principal (usually for rest of world exposures) and provide a waiver of subrogation
in favor of Pfizer and its Affiliates. Such insurance policies shall be primary and non-contributing with respect to any other
similar insurance policies available to Pfizer or its Affiliates. Any deductibles for such insurance shall be assumed by Licensee.


 


15.2         Policy
Notification.


 


Licensee shall provide
Pfizer with certified copies of such policies or original certificates of insurance evidencing such insurance: (a) within twenty
(20) Business Days after the execution by both Parties of this Agreement, and (b) prior to expiration of any one coverage. Licensee
shall provide that Pfizer shall be given at least thirty (30) days written notice prior to cancellation, termination, or any material
change to restrict the coverage or reduce the limits afforded.


 


16.         Dispute
Resolution.


 


16.1         Arbitration.


 


16.1.1 General.
Any disputes, controversies or other claims arising out of this Agreement, its interpretation, validity, performance, enforceability,
breach or termination (“Disputes”) that are not settled amicably shall be referred by sending written notice
of the Dispute to the other Party for final and binding arbitration with the office of the American Arbitration Association in
New York County, New York in accordance with the then-prevailing commercial arbitration rules of the American Arbitration Association.


 


16.1.2 Number of Arbitrators.
The arbitration shall be settled by one (1) arbitrator who is neutral to the Parties, and the Parties shall endeavor to jointly
appoint the arbitrator. If the Parties fail to jointly appoint the arbitrator within (15) fifteen days of the arbitration being
initiated, the appointment shall be made by the American Arbitration Association.


 




    	47



     


    

 


16.1.3 Powers of the
Arbitrator.


 


(a)          The
arbitrator is authorized to award to the prevailing Party, if a prevailing party is determined by the arbitrator, such Party’s
costs and expenses, including attorneys’ fees.


 


(b)          Except
as set forth in Article 12, the arbitrator may not award punitive, exemplary, or consequential damages, nor may the arbitrator
apply any multiplier to any award of actual damages, except as may be required by statute;


 


(c)          Any
award by the arbitrator shall be subject to the limitations in Section 12.2;


 


(d)          The
arbitrator shall have the discretion to hear and determine at any stage of the arbitration any issue asserted by any Party to be
dispositive of any claim or counterclaim, in whole or part, in accordance with such procedure as the arbitrator may deem appropriate,
and the arbitrator may render an award on such issue.


 


(e)          In
addition to the authority conferred on the arbitrator by the rules designated in this Agreement, and without prejudice to any provisional
measures that may be available from a court of competent jurisdiction, the arbitrator shall have the power to grant any provisional
measures that the arbitrator deems appropriate, including but not limited to provisional injunctive relief, and any provisional
measures ordered by the arbitrator may, to the extent permitted by Applicable Law, be deemed to be a final award on the subject
matter of the measures and shall be enforceable as such.


 


16.1.4 Confidentiality.
Upon any initiation of an arbitration in accordance with this Article 16, the Parties shall negotiate in good faith a separate
agreement governing the confidentiality of all information used or disclosed in such arbitration.


 


16.2        No
Trial By Jury.


 


THE PARTIES EXPRESSLY
WAIVE AND FOREGO ANY RIGHT TO TRIAL BY JURY.


 


17.         General
Provisions.


 


17.1        Assignment.


 


Neither Party may assign
its rights and obligations under this Agreement without the other Party’s prior written consent, except that: (a) Pfizer
may assign to a Third Party its rights to receive some or all of the payments payable hereunder, (b) each Party may assign its
rights and obligations under this Agreement or any part hereof to one or more of its Affiliates without the consent of the other
Party; and (c) either Party may assign this Agreement in the event of a Change of Control of such Party. The assigning Party shall
provide the other Party with prompt written notice of any such assignment. Any permitted assignee pursuant to clauses (b) and (c)
above shall assume all obligations of its assignor under this Agreement, and no permitted assignment shall relieve the assignor
of liability for its obligations hereunder. Any attempted assignment in contravention of the foregoing shall be void.


 




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17.2         Severability.


 


Should one or more
of the provisions of this Agreement become void or unenforceable as a matter of law, then such provision will be ineffective only
to the extent of such prohibition or invalidity, without invalidating the remainder of this Agreement, and the Parties agree to
substitute a valid and enforceable provision therefor which, as nearly as possible, achieves the desired economic effect and mutual
understanding of the Parties under this Agreement.


 


17.3         Governing
Law.


 


This Agreement shall
be governed by and construed under the laws in effect in the State of New York, U.S. without giving effect to any conflicts of
laws provision thereof or of any other jurisdiction that would produce a contrary result. Article 16 does not intend to
deprive any court of competent jurisdiction with respect to its power to issue a pre-arbitral injunction, pre-arbitral attachment
or other order in aid of arbitration proceedings or the enforcement of any judgment or award. In any such action, the courts located
in the Southern District of New York shall have exclusive jurisdiction over any action brought to enforce this Agreement, and each
of the Parties irrevocably: (a) submits to such exclusive jurisdiction for such purpose; (b) waives any objection which it may
have at any time to the laying of venue of any proceedings brought in such courts;


 


(a)          waives
any claim that such proceedings have been brought in an inconvenient forum; and (d) further waives the right to object with respect
to such proceedings that any such court does not have jurisdiction over such Party; and (e) consents to service of process in the
manner provided by Section 17.8 or by first class certified mail, return receipt requested, postage prepaid.


 


17.4         Force
Majeure.


 


Except with respect
to delays or nonperformance caused by the negligent or intentional act or omission of a Party, any delay or nonperformance by such
Party (other than payment obligations under this Agreement) will not be considered a breach of this Agreement to the extent such
delay or nonperformance is caused by acts of God, natural disasters, acts of any Government Authority or civil or military authority,
fire, floods, epidemics, quarantine, energy crises, war or riots or any other cause outside of the reasonable control of such Party
(each, a “Force Majeure Event”), provided that the Party affected by such Force Majeure Event will promptly
begin or resume performance as soon as reasonably practicable after the event has abated. If the Force Majeure Event prevents a
Party from performing any of its obligations under this Agreement for two hundred seventy (270) days or more, then the other Party
may terminate this Agreement immediately upon written notice to the non-performing Party.


 


17.5         Waivers
and Amendments.


 


The failure of any
Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not constitute
a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party. No waiver
shall be effective unless it has been given in writing and signed by the Party giving such waiver. No provision of this Agreement
may be amended or modified other than by a written document signed by authorized representatives of each Party.


 




    	49



     


    

 


17.6         Relationship
of the Parties.


 


Nothing contained in
this Agreement shall be deemed to constitute a partnership, joint venture, or legal entity of any type between Pfizer and Licensee,
or to constitute one Party as the agent of the other. Moreover, each Party agrees not to construe this Agreement, or any of the
transactions contemplated hereby, as a partnership for any tax purposes. Each Party shall act solely as an independent contractor,
and nothing in this Agreement shall be construed to give any Party the power or authority to act for, bind, or commit the other
Party.


 


17.7         Successors
and Assigns.


 


This Agreement shall
be binding upon and inure to the benefit of the Parties and their respective successors and permitted assigns.


 


17.8         Notices.


 


All notices, consents,
waivers, and other communications under this Agreement must be in writing and will be deemed to have been duly given when: (a)
delivered by hand (with written confirmation of receipt), (b) sent by fax (with written confirmation of receipt), provided that
a copy is sent by an internationally recognized overnight delivery service (receipt requested), or (c) when received by the addressee,
if sent by an internationally recognized overnight delivery service (receipt requested), in each case to the appropriate addresses
and fax numbers set forth below (or to such other addresses and fax numbers as a Party may designate by written notice):


 


If to Pfizer Inc.:


 


Pfizer Inc.

235 East 42nd Street

New York, NY 10017

Fax: 646-348-8157

Attention: Senior Vice President, Business Development


 


With a copy (which shall not constitute notice) to:


 


Pfizer Inc.

New York, NY 10017

Fax: 646-348-8157

Attn: General Counsel


 


If to PPI:


 


Pfizer Products Inc.

235 East 42nd Street

New York, NY 10017

Fax: 646-348-8157

Attention: Senior Vice President, Business Development


 




    	50



     


    

 


With a copy (which shall not constitute notice) to:


 


Pfizer Products Inc.

235 East 42nd Street

New York, NY 10017

Fax: 646-348-8157

Attention: General Counsel


 


If to Licensee:


 


SpringWorks Subsidiary 2, Inc.

100 Washington Blvd., 5th Floor

Stamford, CT 06902

Attn: Chief Executive Officer


 


With a copy (which shall not constitute notice) to:


 


SpringWorks Subsidiary 2, Inc.

100 Washington Blvd., 5th Floor

Stamford, CT 06902

Attn: General Counsel


 


If to SpringWorks:


 


SpringWorks Therapeutics, Inc.

100 Washington Blvd., 5th Floor

Stamford, CT 06902

Attn: Chief Executive Officer


 


With a copy (which shall not constitute notice) to:


 


SpringWorks Therapeutics, Inc.

100 Washington Blvd., 5th Floor

Stamford, CT 06902

Attn: General Counsel


 


17.9         Further
Assurances.


 


Licensee and Pfizer
hereby covenant and agree without the necessity of any further consideration, to execute, acknowledge and deliver any and all such
other documents and take any such other action as may be reasonably necessary or appropriate to carry out the intent and purposes
of this Agreement.


 


17.10         No
Third Party Beneficiary Rights.


 


This Agreement is not
intended to and shall not be construed to give any Third Party any third party beneficiary rights or other rights to enforce this
Agreement or any provision contained herein or contemplated hereby.


 




    	51



     


    

 


17.11        Entire
Agreement.


 


17.11.1 This Agreement,
together with its Schedules, sets forth the entire agreement and understanding of the Parties as to the subject matter hereof and
supersedes all proposals, oral or written, and all other prior communications between the Parties with respect to such subject
matter.


 


17.11.2 In the event
of any conflict between a material provision of this Agreement and any Schedule hereto, the Agreement shall control.


 


17.12        Counterparts.


 


This Agreement may
be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute
one and the same instrument.


 


17.13        Cumulative
Remedies.


 


No remedy referred
to in this Agreement is intended to be exclusive, but each shall be cumulative and in addition to any other remedy referred to
in this Agreement or otherwise available under law.


 


17.14        Waiver
of Rule of Construction.


 


Each Party has had
the opportunity to consult with counsel in connection with the review, drafting, and negotiation of this Agreement. Accordingly,
any rule of construction that any ambiguity in this Agreement shall be construed against the drafting Party shall not apply.


 


[Signature page to follow]


 




    	52



     


    

 


IN WITNESS WHEREOF,
the Parties intending to be bound have caused this Agreement to be executed by their duly authorized representatives as of the
Amendment Effective Date.


 


SPRINGWORKS SUBSIDIARY 2, INC.


 


	By: 	/s/ Saqib Islam	 
	Name:	Saqib Islam	 
	Title:	Chief Executive Officer	 


 


SIGNATURE PAGE TO AMENDED AND RESTATED
LICENSE AGREEMENT


 




     


     


    

 


 


IN WITNESS WHEREOF,
the Parties intending to be bound have caused this Agreement to be executed by their duly authorized representatives as of the
Amendment Effective Date.


 


PFIZER INC.


 


	By:	/s/ Doug Giordano	 
	Name:	Doug Giordano	 
	Title:	Senior Vice President, Worldwide Business Development	 


 


SIGNATURE PAGE TO AMENDED AND RESTATED
LICENSE AGREEMENT


 




     


     


    

 


 


IN WITNESS WHEREOF,
the Parties intending to be bound have caused this Agreement to be executed by their duly authorized representatives as of the
Amendment Effective Date.


 


PFIZER PRODUCTS INC.


 


	By:	/s/ Tiffany Trunko	 
	Name:	Tiffany Trunko	 
	Title:	Vice President and Assistant General Counsel	 


 


SIGNATURE PAGE TO AMENDED AND RESTATED
LICENSE AGREEMENT


 




     


     


    

 


 


IN WITNESS WHEREOF,
the Parties intending to be bound have caused this Agreement to be executed by their duly authorized representatives as of the
Amendment Effective Date.


 


SPRINGWORKS THERAPEUTICS, INC.


 


(Solely for purposes of Article 11
and Sections 3.2 and 3.3)


 


	By:  	/s/ Saqib Islam	 
	Name:	Saqib Islam	 
	Title:	Chief Executive Officer	 


 


SIGNATURE PAGE TO AMENDED AND RESTATED
LICENSE AGREEMENT


 




     


     


    

 


SCHEDULE A


 


[***]


 


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 





    	Schedule A-1



     


    

 


SCHEDULE B 


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule B-1



     


    

 


SCHEDULE C 


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule C-1



     


    

 


SCHEDULE D 


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule D-1



     


    

 


SCHEDULE E 


 


[***]


 


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 





    	Schedule E-1



     


    

 


SCHEDULE F






[***]


 


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 





    	Schedule F-1



     


    

 


SCHEDULE G 


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule G-1



     


    

 


SCHEDULE H






[***]


 


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 





    	Schedule H-1



     


    

 


SCHEDULE I


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule I-1



     


    

 


SCHEDULE J


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule J-1



     


    

 


SCHEDULE K


 


[***]


 








[***]
Certain information in this document has been omitted from this exhibit because it is both (i) not material and (ii) would be
competitively harmful if publicly disclosed.


 



 




    	Schedule K-1