EX-10.1





 Exhibit 10.1 

AMENDMENT NO. 1 TO WARRANT AGREEMENT 

This Amendment (this “Amendment”) is made as of August 19, 2019 by and between Organogenesis Holdings Inc., a Delaware
corporation f/k/a Avista Healthcare Public Acquisition Corp. (the “Company”), and Continental Stock Transfer & Trust Company, a New York corporation, as warrant agent (the “Warrant Agent”), and constitutes
an amendment to that certain Warrant Agreement, dated as of October 10, 2016 (the “Existing Warrant Agreement”), between the Company and the Warrant Agent. Capitalized terms used but not otherwise defined in this Amendment
shall have the meanings given to such terms in the Existing Warrant Agreement. 
 WHEREAS, Section 9.8 of the Existing Warrant
Agreement provides that the Company and the Warrant Agent may amend the Existing Warrant Agreement with the written consent of the Registered Holders of 65% of the outstanding Public Warrants; 

WHEREAS, the Company desires to amend the Existing Warrant Agreement to provide the Company with the right to require the holders of Public
Warrants to exchange all of the outstanding Public Warrants for shares of the Company’s Class A Common Stock, par value $0.0001 per share, on the terms and subject to the conditions set forth herein; and 

WHEREAS, following a consent solicitation undertaken by the Company, the Registered Holders of more than 65% of the outstanding Public
Warrants have consented to and approved this Amendment. 
 NOW, THEREFORE, in consideration of the mutual agreements contained herein and
other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound hereby, the parties hereto agree to amend the Existing Warrant Agreement as set forth herein. 

1.    Amendment of Existing Warrant Agreement. The Existing Warrant Agreement is hereby amended by adding the new
Section 6A thereto: 
 “6A    Mandatory Exchange. 

6A.1    Company Election to Exchange. Notwithstanding any other provision in this Agreement to the
contrary, not less than all of the outstanding Warrants may be exchanged, at the option of the Company, at any time while they are exercisable and prior to their expiration, at the office of the Warrant Agent, upon notice to the Registered Holders
of the Warrants, as described in Section 6A.2 below, for shares of Common Stock, at the exchange rate of 0.0855 shares of Common Stock for every Warrant held by the holder thereof (the “Consideration”)
(subject to equitable adjustment by the Company in the event of any stock splits, stock dividends, recapitalizations or similar transaction with respect to the Common Stock). The aggregate Consideration payable to each former Registered Holder shall
be rounded up to the nearest whole Share after multiplying the aggregate number of outstanding Warrants held by such former Registered Holder by the Consideration. 

  
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 6A.2    Date Fixed for, and Notice of, Exchange.
In the event that the Company elects to exchange all of the Warrants, the Company shall fix a date for the exchange (the “Exchange Date”). Notice of exchange shall be mailed by first class mail, postage prepaid, by the Company not
less than fifteen (15) days prior to the Exchange Date to the Registered Holders of the Warrants at their last addresses as they shall appear on the registration books. Any notice mailed in the manner herein provided shall be conclusively
presumed to have been duly given whether or not the Registered Holder received such notice. 

6A.3    Exercise After Notice of Exchange. The Warrants may be exercised, for cash (or on a
“cashless basis” in accordance with subsection 3.3.1(b) of this Agreement) at any time after notice of redemption shall have been given by the Company pursuant to Section 6A.2 hereof and prior to the
Exchange Date. On and after the Exchange Date, the record holder of the Warrants shall have no further rights except to receive, upon surrender of the Warrants, the Consideration. 

2.    Miscellaneous Provisions. 

2.1    Severability. This Amendment shall be deemed severable, and the invalidity or unenforceability of any term or
provision hereof shall not affect the validity or enforceability of this Amendment or of any other term or provision hereof. Furthermore, in lieu of any such invalid or unenforceable term or provision, the parties hereto intend that there shall be
added as a part of this Amendment a provision as similar in terms to such invalid or unenforceable provision as may be possible and be valid and enforceable. 

2.2    Applicable Law. The validity, interpretation and performance of this Amendment shall be governed in all
respects by the laws of the State of New York, without giving effect to conflict of laws. The parties hereby agree that any action, proceeding or claim against it arising out of or relating in any way to this Amendment shall be brought and enforced
in the courts of the State of New York or the United States District Court for the Southern District of New York, and irrevocably submits to such jurisdiction, which jurisdiction shall be exclusive. Each of the parties hereby waives any objection to
such exclusive jurisdiction and that such courts represent an inconvenient forum. 
 2.3    Counterparts. This
Amendment may be executed in any number of counterparts, and by facsimile or portable document format (pdf) transmission, and each of such counterparts shall for all purposes be deemed to be an original and all such counterparts shall together
constitute but one and the same instrument. 
 2.4    Effect of Headings. The Section headings herein are for
convenience only and are not part of this Amendment and shall not affect the interpretation thereof. 
 2.5    Entire
Agreement. The Existing Warrant Agreement, as modified by this Amendment, constitutes the entire understanding of the parties and supersedes all prior agreements, understandings, arrangements, promises and commitments, whether written or oral,
express or implied, relating to the subject matter hereof, and all such prior agreements, understandings, arrangements, promises and commitments are hereby canceled and terminated. 

[Signatures Appear on Following Page] 

  
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 IN WITNESS WHEREOF, each of the parties has caused this Amendment to be duly executed as of
the date first above written. 
  

			
	ORGANOGENESIS HOLDINGS INC.
		
	By:	 	/s/ Timothy M. Cunningham
	Name:	 	Timothy M. Cunningham
	Title:	 	Chief Financial Officer


  

			
	CONTINENTAL STOCK TRANSFER & TRUST COMPANY, as Warrant Agent


 
			
		
	By:	 	/s/ Margaret B. Lloyd
	Name:	 	Margaret B. Lloyd
	Title:	 	Vice President


 [Signature Page to Warrant Agreement Amendment] 

  
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