<PAGE>   1
                                                                    EXHIBIT 10.5


[NOTE: CERTAIN PORTIONS OF THIS DOCUMENT HAVE BEEN MARKED TO INDICATE THAT
CONFIDENTIAL TREATMENT HAS BEEN REQUESTED FOR THIS CONFIDENTIAL INFORMATION.
THESE PORTIONS HAVE BEEN MARKED WITH THE CLAUSE "CONFIDENTIAL TREATMENT
REQUESTED" AND/OR TWO ASTERISKS ENCLOSED IN BRACKETS (i.e., [**]). THE
CONFIDENTIAL PORTIONS HAVE BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES
AND EXCHANGE COMMISSION.]


<PAGE>   2



                                                                    Confidential



                           CONTRACT SERVICES AGREEMENT
              RE: GENE EXPRESSION PROFILES IN RHEUMATOID ARTHRITIS


                THIS SERVICES AGREEMENT (this "Agreement"), is entered into as
of June 12, 2001, by and between Encode ehf., a corporation formed under the
laws of Iceland and wholly owned indirect subsidiary of deCODE genetics, Inc.,
having principal offices at Geirsgotu 9, 101 Reykjavik, Iceland ("Encode"), and
Genmab A/S, a public limited liability company (aktieselskab) incorporated under
the laws of Denmark having principal offices at Bredgade 23A 3rd Floor, DK-1260
Copenhagen K, Denmark (the "Client") (Encode and Client collectively, the
"Parties" or each a "Party").

        WHEREAS, the Client wishes Encode to perform, and Encode wishes to
perform, certain services as more particularly provided for, and upon the terms
and conditions stated, in this Agreement.

        NOW, THEREFORE, in consideration of the promises and mutual covenants
contained in this Agreement, the Parties hereto agree as follows:

1.      SERVICES.

        1.1.1   Encode shall perform the services for the Client (the
                "Services") as set forth and described in Schedule A attached
                hereto (the "Study Plan") and in Schedule B attached hereto (the
                "Target Development Plan"), including: (a) the Part I Subject
                Drug Study upon the terms set forth in Section 1.1.2; (b) the
                Part IA CD4 Study upon the terms set forth in Section 1.1.3; (c)
                upon the Successful Completion of the Part I Subject Drug Study
                and upon the terms set forth in Section 1.1.4, the Part II
                Subject Drug Study; (d) the Part IB CD4 Study upon the terms set
                forth in Section 1.1.5; (e) upon the Successful Completion of
                the Part I CD4 Study and upon the terms set forth in Section
                1.1.6, the Part II CD4 Study; and (f) upon the initiation of
                each of the Part II Subject Drug Study and the Part II CD4
                Study, those portions of the Target Development Study relating
                to Subject Drug and CD4, respectively. (The Target Development
                Study and the Drug Studies, including the Part I Subject Drug
                Study, Part II Subject Drug Study, Part IA CD4 Study, Part IB
                CD4 Study and Part II CD4 Study, as such terms are defined in
                Schedule A, Schedule B, the Study Plan or the Target Development
                Plan, collectively referred to herein as the "Studies"). Each of
                the Study Plan and Target Development Plan sets forth the
                Services to be performed, the fees (the "Fees") for such
                Services and the timeline (the "Timeline") for the progress and
                completion of such Services. Encode shall exercise commercially
                reasonable efforts to perform the Services set forth in each of
                the Study Plan and the Target Development Plan in a timely
                manner consistent with the Timeline for such Study. In
                connection with the conduct of the Studies, Encode shall
                maintain complete records of patient identification in
                accordance with applicable EU and U.S. requirements, clinical
                observations, laboratory tests and receipt and disposition of
                the drugs administered during the Studies in accordance with
                Section 3.1 hereof.



                                      -1-
<PAGE>   3

        1.1.2   Upon the execution of this agreement, the Parties shall, in
                accordance with Section 1.2, secure all necessary government
                approvals, including, but not limited to, those set forth by
                applicable institutional review boards and/or ethical
                committees, required in connection with identifying and
                enrolling the cohort of patients for the Part I Subject Drug
                Study. Upon the receipt of all such approvals, Encode will
                promptly initiate the Part I Subject Drug Study as set forth in
                the Study Plan.

        1.1.3   Upon the execution of this agreement, the Parties shall, in
                accordance with Section 1.2, secure all necessary government
                approvals, including, but not limited to, those set forth by
                applicable institutional review boards and/or ethical
                committees, required in connection with identifying and
                enrolling the cohort of patients for the Part IA CD4 Study.
                Within 90 days of receipt of all such approvals, Client will
                provide the Materials and Information relating to the
                identification and enrollment of the cohort of patients for the
                Part IA CD4 Study. Upon receipt of such Materials and
                Information, Encode will promptly initiate the Part IA CD4 Study
                as set forth in the Study Plan. If the patients for the for the
                Part IA CD4 Study are not enrolled by Client within the time
                frame set forth above, then Encode may, in its sole discretion,
                require Client to pay it [**] of the Fee set forth on Schedule
                A, which amount paid by Client will be credited against the
                amount which would be owed by Client in the event it later cures
                its non-performance by enrolling the required patients within
                one (1) year of the execution of this Agreement.

        1.1.4   Within thirty (30) days of Client receiving written report from
                Encode detailing the Successful Completion of the Part I Subject
                Drug Study, Client shall send to Encode its written response to
                such report in the event Client disagrees with the findings of
                the report or otherwise believes the Part I Subject Drug Study
                has not been completed successfully and the matter will be
                resolved through the dispute resolution procedures set forth in
                Section 12 hereof. In the event in the time frame set forth
                above that no response is received from Client or Client's
                response is in agreement with the findings of the report, the
                Part I Subject Drug Study shall be deemed to have succeeded (the
                "Success of the Part I Subject Drug Study"). Upon receipt of
                notice from Encode of the Success of the Part I Subject Drug
                Study, the Parties shall, in accordance with Section 1.2, secure
                all necessary government approvals, including, but not limited
                to, those set forth by applicable institutional review boards
                and/or ethical committees, required in connection with
                identifying and enrolling the cohort of patients for the Part II
                Subject Drug Study. Within 90 days of receipt of all such
                approvals, Client will provide the Materials and Information
                relating to the identification and enrollment of the cohort of
                patients for the Part II Subject Drug Study as set forth on
                Schedule A. Upon receipt of such Materials and Information,
                Encode will promptly initiate (a) the Part II Subject Drug Study
                as set forth in the Study Plan and (b) the Target Development
                Study as to Subject Drug as set forth in the Target Development
                Plan. If the patients for the Part II Subject Drug Study are not
                enrolled by Client within the time frame set forth above, then
                Encode may, in its sole discretion, require Client to pay it
                [**] of the Fee set forth on Schedule A, which amount paid by
                Client will be credited against the amount which would be owed
                by Client in the event it later cures its non-performance by
                enrolling the




                                      -2-
<PAGE>   4

                required patients within one (1) year of Client receiving notice
                from Encode of the Successful Completion of the Part I Subject
                Drug Study.

        1.1.5   Upon the unblinding of the Phase II HuMAX-CD4 study currently
                being undertaken by Client (the "CD4 Start Date"), the Parties
                shall, in accordance with Section 1.2, secure all necessary
                government approvals, including, but not limited to, those set
                forth by applicable institutional review boards and/or ethical
                committees, required in connection with identifying and
                enrolling the cohort of patients for the Part IB CD4 Study.
                Within 90 days of receipt of all such approvals, Client will
                provide the Materials and Information relating to the
                identification and enrollment of the cohort of patients for the
                Part IB CD4 Study as set forth on Schedule A. Upon receipt of
                such Materials and Information, Encode will promptly initiate
                the Part IB CD4 Study as set forth in the Study Plan. If the
                patients for the for the Part IB CD4 Study are not enrolled by
                Client within the time frame set forth above, then Encode may,
                in its sole discretion, require Client to pay it [**] of the Fee
                set forth on Schedule A, which amount paid by Client will be
                credited against the amount which would be owed by Client in the
                event it later cures its non-performance by enrolling the
                required patients within one (1) year of the CD4 Start Date.

        1.1.6   Within thirty (30) days of Client receiving written report from
                Encode detailing the Successful Completion of the Part I CD4
                Study, Client shall send to Encode its written response to such
                report in the event Client disagrees with the findings of the
                report or otherwise believes the Part I CD4 Study has not been
                completed successfully and the matter will be resolved through
                the dispute resolution procedures set forth in Section 12
                hereof. In the event in the time frame set forth above that no
                response is received from Client or Client's response is in
                agreement with the findings of the report, the Part I CD4 Study
                shall be deemed to have succeeded (the "Success of the Part I
                CD4 Study"). Upon receipt of notice from Encode of the Success
                of the Part I CD4 Study, the Parties shall, in accordance with
                Section 1.2, secure all necessary government approvals,
                including, but not limited to, those set forth by applicable
                institutional review boards and/or ethical committees, required
                in connection with identifying and enrolling the cohort of
                patients for the Part II CD4 Study. Within 90 days of receipt of
                all such approvals, Client will provide the Materials and
                Information relating to the identification and enrollment of the
                cohort of patients for the Part II CD4 Study as set forth on
                Schedule A. Upon receipt of such Materials and Information,
                Encode will promptly initiate (a) the Part II CD4 Study as set
                forth in the Study Plan and (b) the Target Development Study as
                to CD4 as set forth in the Target Development Plan. If the
                patients for the Part II CD4 Study are not enrolled by Client
                within the time frame set forth above, then Encode may, in its
                sole discretion, require Client to pay it [**] of the Fee set
                forth on Schedule A, which amount paid by Client will be
                credited against the amount which would be owed by Client in the
                event it later cures its non-performance by enrolling the
                required patients within one (1) year of Client receiving notice
                from Encode of the Successful Completion of the Part I CD4
                Study.



                                      -3-
<PAGE>   5

        1.2     Client shall use commercially reasonable efforts to secure all
necessary non-Icelandic government approvals, including, but not limited to,
those set forth by applicable non-Icelandic institutional review boards and/or
non-Icelandic ethical committees, required in connection with identifying and
enrolling the cohort of patients for the each of the Drug Studies. Encode shall
use commercially reasonable efforts to secure all necessary Icelandic government
approvals, including, but not limited to, those set forth by applicable
Icelandic institutional review boards and/or Icelandic ethical committees,
required in connection with identifying and enrolling the cohort of patients for
the each of the Drug Studies. In addition, Encode, through its investigators,
will be responsible for the content and implementation of the final patient
consent form which prior to use will be approved (i) by an institutional review
board established pursuant to 21 C.F.R. Part 56 ("IRB"), if the Study will be
conducted in the United States, and by any required governmental agency or
comparable organization, if the study will be conducted outside the United
States, and (ii) by the Client. Each Party will give reasonable assistance to
the other Party in connection with obtaining any such approvals.

        1.3     Encode will track the overall safety of the Studies and will
alert the Client to any actual or potential safety concerns, reporting all
adverse reactions and side effects to Client in accordance with the Study Plan
and Target Development Plan, as applicable, and all applicable laws, rules and
regulations.

        1.4     It is agreed that Client's scientific and/or quality assurance
personnel may visit Encode upon reasonable advance notice at any mutually
convenient time(s) for the purpose of monitoring the Services; provided that
such visits do not materially interfere with Encode's business. Encode will
promptly notify Client's Principal Scientist (set forth on Schedule A and
Schedule B, respectively) of any unforeseen or unusual happenings which may
affect the outcome of the Services.

        1.5     Encode warrants that the Services shall be provided in
accordance with: (a) the Study Plan; and (b) in good scientific manner and in
accordance with current good clinical practice; and (c) all applicable national,
federal, state and local laws, regulations and guidelines, including, without
limitation, all applicable health and environmental standards.

2.      CLIENT'S MATERIAL AND INFORMATION.

        2.1     The Client shall provide to Encode the relevant information and
materials required to perform the Services as described in Schedule A and
Schedule B, respectively (the "Materials and Information"), at Client's sole
cost and expense. Title to the Materials and Information shall remain with
Client at all times.

        2.2     Client warrants, as of the date hereof, that to the best of its
knowledge it is the owner of the Materials and Information or is otherwise
permitted to transfer the Materials and Information to Encode for the purposes
contemplated by this Agreement without infringing any intellectual property
rights of any other party; provided, such warranty does not extend to Encode's
use of such Materials and Information.

        2.3     The Materials will be used by Encode in compliance with the
terms and conditions of this Agreement, and all applicable laws and regulations.
Upon termination of this Agreement, Encode



                                      -4-
<PAGE>   6

shall, at its option, either dispose of the Materials in the manner described in
the Information provided by Client, or return the Materials to Client for its
disposal, at Client's expense.

        2.4     Encode will at all times retain possession or control of the
Materials and will provide the Materials only to Encode's employees and/or
consultants, including its investigators) who are directly involved in providing
Services under this Agreement. Pursuant to Section 9.3, such employees and/or
consultants of Encode shall be bound by obligations of confidentiality no less
restrictive than those contained in this Agreement.

3.      RECORDS AND REPORTING.

        3.1     Encode shall keep complete and accurate records, including
reports of all Services performed by it under this Agreement. Such records shall
be available at all reasonable times during normal business hours for
inspection, examination or copying by or on behalf of the Client at Client's
expense. Encode agrees to retain all such records other than such records
relating to clinical trials, including all raw data, at any site selected from
time to time by Encode for a period of not less than two (2) years from the date
of termination of this Agreement. Encode agrees to retain all records relating
to clinical trials undertaken in the Studies, including all raw data, at the
site where such clinical studies are performed for a period of not less than
five (5) years from the date of termination of this Agreement. Encode alone
shall pay for all such storage costs during such time periods. However, after
the expirations of such two (2) and five (5) year time periods, respectively,
Client may, at its option, either have Encode submit all such records to Client
or pay a data storage charge at the rate Encode charges for data storage for
Encode to continue to retain such records. (No raw data will be discarded by
Encode without prior written notice to Client.)

        3.2     Encode shall provide data and information as specified in
Schedule A and Schedule B, respectively (the "Deliverables") and a final report
summarizing the Results (as defined in Section 7.10) of the Services at the
completion of the Services (the "Final Report").

4.      COMPENSATION; PAYMENT. As consideration for the Services provided by
Encode under this Agreement, Encode shall receive the Fees according to the
terms set forth on Schedule A and Schedule B, respectively, and in accordance
with the payment schedule set forth on Schedule A and Schedule B, respectively.
For late payment (more than 30 days) Encode shall charge a monthly late payment
fee, on the first day of each month, calculated as a percentage of the total
amount then outstanding, at the rate of ten (10%) percent plus the last interest
rate set by the European Central Bank in the month for which the fee is
calculated.

5.      TERMINATION.

        5.1     In the event that either Party is in material breach of the
Agreement, the other Party may terminate the Agreement upon 60 days' prior
written notice, during which time the Party in breach may cure such default. In
the event of such a termination due to the Client's material breach (unless
otherwise provided in Section 5.2), the Client shall pay Encode all compensation
for Services that shall



                                      -5-
<PAGE>   7

have accrued, in accordance with the Fees and payment terms set forth in
Schedule A and Schedule B, respectively, as of the effective date of such
termination.

        In the event that such notice is given by Encode, Encode shall
immediately use reasonable efforts to reduce loss and cost to the Client as the
result of such termination. Additionally, in such a case the Client's
obligations will be to pay the balance of any Encode fees incurred as of the
date of termination, including any uncancellable legal obligations to third
parties relating to the performance of the Services under this Agreement, such
as, by way of example, purchase orders which were entered into prior to
receiving the notice of termination.

        5.2     In the event that Encode is not able to provide any of the
Services required in connection with completing any one of the Studies, and such
event is due to Encode's gross negligence or willful misconduct in its
performance of the Services in connection with the Study in question, Encode
will reimburse the Client for fees paid to Encode in connection with those
Services rendered for the Study in question.

6.      SCHEDULE REVISIONS. It is understood by the Parties that certain tasks
involved in the performance of the Services may need to be confirmed and/or
modified as the Services progress and Schedule A and/or Schedule B may require
amendment to meet the Client's objectives. Schedule A and/or Schedule B may be
revised by agreement between the Parties, provided that the Party suggesting the
revision communicates the same in a signed writing to the other Party, and
within ten days thereafter, the other Party indicates acceptance thereof in a
signed writing. In the event that the revision has an impact on the Fees in
Schedule A or Schedule B, Encode shall promptly advise the Client of adjustments
thereto. No change to the Services in Schedule A or Schedule B shall be
implemented before Encode has received written concurrence from Client to the
change to the Services in Schedule A or Schedule B and to any consequent change
in the Fees in Schedule A or Schedule B.

7.      OWNERSHIP OF RESULTS AND DATA RETENTION.

        7.1     "Diagnostic Invention" shall mean any patentable invention or
discovery conceived or reduced to practice during and as a part of the Drug
Studies performed pursuant to this Agreement by Encode's investigators,
employees, or consultants or jointly by such an individual or individuals with
one or more employees of Client. Here and throughout this Agreement, the terms
"conceived" and "reduced to practice" shall be given the meaning of those terms
as they appear in 35 USC Section 102(g). Inventions made solely by Encode's
investigators, employees or consultants shall be the sole property of Encode.
Inventions made jointly by Encode's investigators, employees or consultants with
one or more employee of Client shall be owned jointly by Encode and Client.

        7.2     Encode will offer the Client the first opportunity to enter into
a royalty-bearing license agreement to practice such Diagnostic Invention for
use in diagnostic applications, by exercise of the option provided for in
Section 7.6.1. Encode shall retain all rights to practice such Diagnostic
Invention for all purposes other than for use in diagnostic applications. Such
license shall be [**] in which patents are valid and enforceable for which the
Client does not reasonably assume out-of-pocket costs associated with obtaining
and maintaining letters patent in [**]. All remaining terms of the license,




                                      -6-
<PAGE>   8

including payment (in U.S. dollars) to Encode of running royalties on a
percentage of net sales, to be at least [**] and at most [**], and aggregate
milestone payments, to be at least [**] and at most [**], shall be established
in good faith negotiation by the Parties; provided that the Parties intend that
such terms, royalties, and payments will be determined based on the customary
standards in agreements between commercial entities, taking into account (1) the
type of product that will be developed from such Diagnostic Invention; (2) the
level of contribution of each Party to the development of such product; (3)
whether such Diagnostic Invention is solely owned by Encode or jointly by Encode
and the Client; (4) the degree to which the product will contain active
components covered by intellectual property other than the Diagnostic Invention;
(5) the expected size of the market for such product; and (6) the projected cost
of developing such product.

        7.3     In the event Client exercises its option under Section 7.2 and a
definitive agreement is reached for such license pursuant to Sections 7.6.1 and
7.7, Encode shall have an option under such definitive agreement to elect to
retain or reacquire a [**] right to practice such Diagnostic Invention for use
in diagnostic applications except such applications relating to HuMAX-CD4
(including, without limitation, diagnostic applications relating to the Subject
Drug). In the event Encode exercises such option, (a) the license granted under
the definitive agreement shall be [**] and (b) Encode shall pay Client
("Encode's Payments") [**] of the payments made by Client hereunder (which
payments have not been reimbursed under other such licenses or in connection
with Section 7.7) prior to and including the stage of the Drug Studies in which
such Diagnostic Invention was discovered. [**] of Encode's Payments shall be
made as milestone payments under such license corresponding to the milestones
under which Client will be making payments to Encode. Up to [**] of Encode's
Payments shall be made as royalty payments under such license corresponding to
the royalty payments under which Client will be making payments to Encode.






        7.4     "Therapeutic Invention" shall mean any patentable invention or
discovery conceived or reduced to practice during and as a part of the Target
Development Study performed pursuant to this Agreement by Encode's
investigators, employees, or consultants or jointly by such an individual or
individuals with one or more employees of Client. Here and throughout this
Agreement, the terms "conceived" and "reduced to practice" shall be given the
meaning of those terms as they appear in 35 USC Section 102(g). Inventions made
solely by Encode's investigators, employees or consultants shall be the sole
property of Encode. Inventions made jointly by Encode's investigators, employees
or consultants with one or more employee of Client shall be owned jointly by
Encode and Client. (Diagnostic Invention and Therapeutic Invention may be
collectively and individually referred to as an "Invention").

        7.5     Encode will offer the Client the first opportunity to enter into
a royalty-bearing license agreement to practice such Therapeutic Invention for
use in human monoclonal antibody products, by exercise of the option provided
for in Section 7.6.2. Encode shall retain all rights to practice such Diagnostic
Invention for all purposes other than for use in diagnostic applications. Such
license shall be



                                      -7-
<PAGE>   9

[**] in which patents are valid and enforceable for which the Client does not
reasonably assume out-of-pocket costs associated with obtaining and maintaining
letters patent in [**]. All remaining terms of the license, including payment
(in U.S. dollars) to Encode of running royalties on a percentage of net sales,
to be at least [**] and at most [**], and aggregate milestone payments, to be at
least [**] and at most [**], shall be established in good faith negotiation by
the Parties; provided that the Parties intend that such terms, royalties, and
payments will be determined based on the customary standards in agreements
between commercial entities, taking into account (1) the type of product that
will be developed from such Therapeutic Invention; (2) the level of contribution
of each Party to the development of such product; (3) whether such Therapeutic
Invention is solely owned by Encode or jointly by Encode and the Client; (4) the
degree to which the product will contain active components covered by
intellectual property other than the Therapeutic Invention; (5) the expected
size of the market for such product; and (6) the projected cost of developing
such product.

        7.6.1   Encode shall promptly notify the Client, in writing, of any
Diagnostic Invention. The notice shall provide a reasonably detailed written
description of the Diagnostic Invention. The Client shall have the option to
obtain the license identified in Section 7.2 with respect to the identified
Diagnostic Invention by written notification to Encode at any time prior to
[**]; provided, however that if, at any time after the completion of the
Services set forth in the Study Plan (regardless of the results obtained in any
of the Studies in the Study Plan or whether or not the Part II Subject Drug
Study or the Part II CD4 Study were undertaken pursuant to Sections 1.1.2 and
1.1.4, respectively, provided the various time periods for the delivery of the
Materials and Information by Client have expired), Encode receives a bona fide
offer from [**] such Diagnostic Invention, then Client shall have [**] from
receipt of notice of such [**] from Encode to [**] in accordance with Section
7.7. In the event of [**], a failure by the Client to timely notify Encode shall
be deemed a waiver of the [**] with respect to the identified Diagnostic
Invention, but not with respect to other Inventions subject to this Agreement.
In the event Encode enters into license negotiations with a third party with
regard to a Diagnostic Invention pursuant to Sections 7.6.1 or 7.7, Encode shall
use reasonable efforts to ensure that such third party licensee shall (a) grant
to Client the right to use such Diagnostic Invention during clinical trials of
HuMAX-CD4, and (b) to market any diagnostic product resulting from such
Diagnostic Invention in the United States.

        7.6.2   Encode shall promptly notify the Client, in writing, of any
Therapeutic Invention. The notice shall provide a reasonably detailed written
description of the Therapeutic Invention. The Client shall have [**] after
receipt of such notice to exercise the option to obtain the license identified
in Section 7.5 with respect to the identified Therapeutic Invention by written
notification to Encode. A failure by the Client to timely notify Encode shall be
deemed a waiver of the Client's option with respect to the identified
Therapeutic Invention, but not with respect to other Inventions subject to this
Agreement.

        7.7     If the Client exercises an option pursuant to Sections 7.6.1 or
7.6.2, the Parties shall immediately enter into negotiations for the definitive
license agreement. If a license has not been executed within [**] of the
Client's exercise of the option, Client shall reduce to a writing a summary of
the terms last offered by Client (the "Minimum Terms"). After the passage of
such [**] period of time, Encode shall have the right to grant such license
rights to a third party, provided that if the terms of such license sets forth
the same terms as the Minimum Terms or terms more favorable to



                                      -8-
<PAGE>   10
 such third party than the Minimum Terms, then Encode will present such terms to
Client and Client shall have the right to accept such terms, and further
provided that, within [**] after the execution of such a third party license,
Encode shall reimburse Client for [**] of (a) the payments made by Client
hereunder (which payments have not been reimbursed under other such licenses or
in connection with Section 7.3) prior to and including the stage of the Drug
Studies in which such Diagnostic Invention was discovered, in the case of a
license to a Diagnostic Invention, or (b) the payments made by Client to Encode
in connection with the Target Development Study (which payments have not been
reimbursed under other such licenses), in the case of a license to a Therapeutic
Invention.

        7.8     The right of publication by Encode, as indicated in Section 10,
shall not be affected by a license to any Invention. Further, Encode shall
retain all rights to practice any Diagnostic Invention for all purposes other
than for use in diagnostic applications, and Encode shall retain all rights to
practice any Therapeutic Invention for all purposes other than for use in human
monoclonal antibody products.

        7.9     At any time that Encode is providing information to Client
regarding an Invention, if Encode is interested in entering into a collaborative
development and marketing arrangement with respect to either a Diagnostics
Invention or a Therapeutic Invention for which Client has an option as described
above, Encode shall so advise Client. If Client is interested in pursuing such
an arrangement in lieu of exercising its option for a license, then Client shall
advise Encode within [**] thereafter (or such longer period if such time is
otherwise extended by written agreement of Encode and Client), the option
exercise right shall be deferred, and the Parties shall enter into good faith
negotiations for such an arrangement. If the Parties do not enter into
definitive documents for such an arrangement within [**] thereafter, then Client
will have [**] to advise Encode of its desire to exercise its option to acquire
a license, in which case the Parties will follow the procedure for such
negotiations set forth in Section 7.2 or 7.5, as the case may be.

        7.10    For purposes of this Agreement, "Study Results" with respect to
each of the Target Development Study and the Drug Studies, including the Part I
Subject Drug Study, Part II Subject Drug Study, Part IA CD4 Study, Part IB CD4
Study and Part II CD4 Study, shall mean any and all data, results and
information, other than Inventions, generated by or arising from the conduct of
each of such Studies pursuant to this Agreement. For purposes of this Agreement,
"Results" shall mean the Study Results for all of the Studies.

        7.11    Encode shall own the Study Results with respect to Part I
Subject Drug Study, Part II Subject Drug Study, and the Target Development
Study, (collectively, "Encode's Study Results"), and shall have the right to use
Encode's Study Results for any purposes and in any manner without obligation to
the Client, except that with respect to any Encode's Study Results relating to
any Materials provided by the Client that are proprietary to the Client, Encode
shall not have the right to publish Encode's Study Results except as provided in
Section 10. The Client shall have the right to (i) use Encode's Study Results
for the purpose of developing, marketing and selling HuMAX-CD4, or products
developed therefrom, that are proprietary to the Client, including the right of
publication pursuant to Section 10, (ii) include Encode's Study Results in
submissions to the FDA and other regulatory authorities, and (iii) include
Encode's Study Results in marketing materials to the extent permitted by law.



                                      -9-
<PAGE>   11

        7.12    Client shall own the Study Results with respect to Part IA CD4
Study, Part IB CD4 Study and Part II CD4 Study, (collectively, "Client's Study
Results"), and shall have the right to use Client's Study Results for any
purposes and in any manner without obligation to Encode. Encode shall have the
right to (i) exploit Client's Study Results for its internal research and
discovery purposes (as opposed to the development, commercialization or other
exploitation of products or technology resulting therefrom), without the consent
of the Client; and (ii) store and use Client's Study Results in the Icelandic
Health Sector Database and the genealogical and genotypic databases of deCODE
genetics, Inc. and its affiliates (collectively, "deCODE") and such other
databases as may be created or developed by deCODE from time to time during the
term of this Agreement.

        7.13    Except as expressly set forth in this agreement or any
subsequent license agreement that is executed between the Parties pursuant to
Section 7.7, the Parties will follow United States laws of inventorship with
respect to ownership and patenting rights.

8.      NO OTHER RIGHTS. Except as otherwise provided in this Agreement and as
necessary for Encode to conduct the Study, under no circumstances will either
Party, as a result of this Agreement, obtain any ownership, license or other
interest or rights in any technology, material or intellectual property of the
other Party, including any items transferred by such other Party to such Party
at any time pursuant to this Agreement, except as specifically provided in this
Agreement.

9.      CONFIDENTIALITY.

        9.1     For the purposes of this Agreement, the term "Client's
Confidential Material" shall mean: (a) the Materials; (b) any information
specifically relating to the Materials that (i) is provided by Client to Encode
in accord with the provisions of this Agreement; or, (ii) arises from the
Services; or (c) any information specifically relating to Client's Study
Results. The term "Encode's Confidential Material" shall mean (a) any
information specifically relating to Encode's Study Results; or (b) relates to
Encode's operations, including without limitation, Encode's proprietary
inventions, processes and other assets, including but not limited to proprietary
methods, procedures and techniques, procedure manuals, personal and scientific
data, financial information, computer technical expertise and software which
have been independently developed by Encode. The term "Confidential Material"
shall refer to Client's Confidential Material and/or Encode's Confidential
Material collectively and/or separately as the case might be.

        9.2     To be considered Confidential Material, information must either
be supplied in written, graphic, photographic, electronic or other tangible
form, marked "Confidential" and identified as being disclosed under this
Agreement, or initially disclosed in oral or another non-tangible form and
subsequently reduced to writing and marked "Confidential" by the Party making
the disclosure (the "Disclosing Party") within thirty (30) days of the date of
initial disclosure. Client's Confidential Material shall include the
Information. Notwithstanding the foregoing, Confidential Material shall not
include information that: (a) can be demonstrated by the Party receiving the
disclosure (the "Receiving Party") to have been publicly known at the time of
the Disclosing Party's disclosure of such Confidential Material to the Receiving
Party; or, (b) can be demonstrated to have been in the possession of the
Receiving Party prior to the Disclosing Party's disclosure of such Confidential
Material to the Receiving Party; or, (c) is obtained by the Receiving Party from
a third party who has a lawful right to disclose such



                                      -10-
<PAGE>   12

information free of any obligation to the Disclosing Party; or (d) becomes part
of the public domain or publicly known, by publications or otherwise, not due to
any unauthorized act or omission by the Receiving Party; or, (e) can be
demonstrated as independently developed or acquired by the Receiving Party
without reference to or reliance upon such Confidential Material, as evidenced
by the Receiving Party's written records.

        9.3     During the term of this Agreement and for a period of five (5)
years thereafter, each Receiving Party shall: (a) maintain in strict confidence
all of the Disclosing Party's Confidential Material; (b) limit access to the
Disclosing Party's Confidential Material to those of its employees, affiliates
and consultants who reasonably need to know the Disclosing Party's Confidential
Material, and who are bound by obligations of confidentiality no less
restrictive than those contained in this Agreement; (c) advise any and all such
employees, affiliates and consultants of the confidential nature of the other
Party's Confidential Material; (d) use the Disclosing Party's Confidential
Material solely for the performance of its obligations hereunder; (e) ensure
that any Party to which the Disclosing Party's Confidential Material is
disclosed shall abide by the provisions of this Agreement; and (f) except as is
provided for by this Agreement, not disclose any of the Disclosing Party's
Confidential Material to any third party for any reason without the prior
written consent of the Disclosing Party.

        9.4     The foregoing obligations of confidentiality not withstanding,
the Receiving Party shall be entitled to disclose the Disclosing Party's
Confidential Material when such disclosure is required by law, governmental
regulation, or court order, provided that (a) the Receiving Party notifies the
Disclosing Party in advance of any such disclosure, with sufficient notice to
permit the Disclosing Party to seek a protective order, and the Receiving Party
shall assist the Disclosing Party to obtain such protective order at the
Disclosing Party's expense, and (b) in the event that time is not available to
notify the Disclosing Party as set forth in (a) above, the Receiving Party shall
seek such protective order itself at the Disclosing Party's reasonable expense,
and (c) such disclosure is limited to the Disclosing Party's Confidential
Material requested and only to the extent necessary to comply with the order,
and (d) the Receiving Party shall continue to treat as Confidential all such
information with respect to other third parties.

        9.5     All Confidential Material shall remain the exclusive property of
the Disclosing Party and shall be promptly returned or destroyed by the
Receiving Party upon request of the Disclosing Party and, in any event,
following the expiration or termination of this Agreement (provided that the
Receiving Party shall be entitled to retain a single copy thereof for archival
purposes only).

        9.6     Nothing in this Section 9 shall be construed to prevent each of
the Parties from disclosing the existence of the relationship with the other
Party pursuant to this Agreement, including the right to use the name of the
other Party in any such disclosure.

        9.7     This provision shall supercede any prior agreements between the
Parties relating to confidentiality obligations.

        10      PRESS RELEASES; PUBLICATIONS.



                                      -11-
<PAGE>   13

        10.1    PRESS RELEASES. Press releases or other similar public
communication by any Party relating to this Agreement, shall be approved in
advance by the other Party, which approval shall not be unreasonably withheld or
delayed, except for those communications required by applicable law (which shall
be provided to the other Party as soon as practicable after the release or
communication thereof), disclosures of information for which consent has
previously been obtained, and information of a similar nature to that which has
been previously disclosed publicly with respect to this Agreement, each of which
shall not require advance approval.

        10.2    PUBLICATIONS. The Parties acknowledge that scientific lead-time
is a key element of the value of the research and development activities under
this Agreement and further agree that scientific publications must be strictly
monitored to prevent any adverse effect from premature publication of results of
the research or development activities hereunder. At least sixty (60) days prior
to submission of any material related to the research or development activities
hereunder for publication or presentation, the submitting Party shall provide to
the other Party a draft of such material for its review and comment. The
receiving Party shall provide any comments to the submitting Party within thirty
(30) days of receipt of such materials. No publication or presentation with
respect to the research or development activities hereunder which relate to
Client's proprietary Materials shall be made by Encode unless and until Client's
comments on the proposed publication or presentation have been addressed,
changes have been agreed upon, and any information determined by Client to be
Confidential Material has been removed. With respect to any other publication or
presentation with respect to the research and development activities undertaken
hereunder, neither Party shall make any publication or presentation without the
prior review of the other Party, which shall not be unreasonably delayed and the
publishing party shall take into consideration any comments made by the other
party on the proposed publication or presentation. In all cases, each Party
agrees that such Party shall provide appropriate representation and
acknowledgement of the other Party in any publication or presentation for the
respective contributions of the scientists employed by the other Party with
regard to the subject matter of such publication or presentation. If requested
in writing by the other Party, the submitting Party shall withhold material from
submission for publication or presentation for an additional sixty (90) days to
allow for the filing of a patent application or the taking of such measures to
establish and preserve proprietary rights in the information in the material
being submitted for publication or presentation.

11.     INDEMNIFICATION.

        11.1    The Client agrees that it will indemnify and hold harmless
Encode, its directors, officers, employees and agents against any and all
amounts paid or payable to third parties (including reasonable attorneys' fees)
arising out of actions, suits, claims, demands or prosecutions ("Actions")
arising from this Agreement that may be brought or instituted against Encode,
its directors, officers, employees and agents, unless such Action is the result
of Encode's gross negligence or willful misconduct in connection with the
Services. Notwithstanding the foregoing Client shall not be liable to Encode for
any amount exceeding the aggregate fees actually paid by the Client to Encode
under this Agreement.

        11.2    Encode agrees that it will indemnify and hold harmless the
Client, its directors, officers, employees and agents against any and all
amounts paid or payable to third parties (including reasonable attorneys' fees)
arising out of Actions arising from this Agreement that may be brought or
instituted



                                      -12-
<PAGE>   14

against the Client, its directors, officers, employees and agents, unless such
Action is the result of Client's gross negligence or willful misconduct in
connection with the Services. Notwithstanding the foregoing Encode shall not be
liable to the Client for any amount exceeding the aggregate fees actually paid
by the Client to Encode under this Agreement.

        11.3    Each of Encode and the Client, at its own expense, will maintain
insurance coverage (including appropriate tail coverage) of a type and amount to
cover any and all costs, demands, losses, liabilities and expenses with respect
to which such Party is obligated to indemnify the other Party under this
Agreement. Either Party, upon the request of the other Party, will provide
written evidence of such coverage.

        11.4    Any person seeking indemnification under this Section 11 (an
"indemnified Party"): (i) will give the Party obligated to indemnify (the
"indemnifying Party") prompt notice of any Action as soon as practicable; (ii)
will permit the indemnifying Party to control any litigation or dispute
resolution concerning, and the disposition of, such Actions, so long as such
disposition does not materially adversely affect the indemnified Party or its
affiliates; and (iii) will fully cooperate with the indemnifying Party and its
legal representatives in the investigation of any matter that is the subject of
indemnification.

        11.5    Encode warrants that the Services shall be conducted with
reasonable care in accordance with Schedule A and Schedule B. In the event that
Encode defaults on this warranty with respect to the Services or any portion
thereof, the Client's sole and exclusive remedy shall be to have Encode correct
or re-perform such Services or, if Encode reasonably determines that such remedy
is not economically or technically feasible, to obtain an equitable partial or
full refund of amounts paid with respect to the defective Services. This
warranty is in lieu of any and all other warranties relating to the Services,
expressed or implied, including, without limitation, any implied warranties of
merchantability or fitness for a particular purpose.

12.     USE OF NAMES. Each Party may use the name, insignia, symbol, trademark,
trade name or logotype of another Party only (a) in connection with
announcements and other permitted disclosures relating to this Agreement and the
activities contemplated hereby, (b) as required by Applicable Law, and (c)
otherwise as agreed in writing by such other Party.

13.     DISPUTES. Any dispute that may arise relating to the terms of this
Agreement or the activities of the Parties hereunder shall be referred to the
Chief Executive Officers of each of the Parties (or their respective designees)
who shall use their good faith efforts to mutually agree upon the proper course
of action to resolve the dispute. If any dispute is not resolved by the Chief
Executive Officers (or their designees) within ten (10) business days after an
issue is referred to them, or such longer period as the Chief Executive Officers
(or their respective designees) may collectively agree, then either Party shall
have the right to pursue arbitration in accordance with Section 23 or to pursue
such other dispute resolution mechanism as the Parties may agree.

14.     DELAYS. During the term of this Agreement, if either Party ("Delayed
Party") experiences any delays in its performance of any of the Services as a
result, in whole or in part, due to the other Party's ("Delaying Party")
inability to provide Delayed Party with the required Materials and/or
Information, Delayed Party reserves the right to adjust the Timeline and the
Fees, if appropriate, to compensate



                                      -13-
<PAGE>   15

Delayed Party for loss of use of resources and permit Delayed Party to
reschedule such Services in a manner consistent with its obligations under other
contracts. In such event, Delayed Party shall promptly notify Delaying Party of
any such adjustments.

15.     FORCE MAJEURE. Neither Party shall be held liable or responsible to the
other Party nor be deemed to be in default under, or in breach of any provision
of, this Agreement for failure or delay in fulfilling or performing any
obligation of this Agreement when such failure or delay is due to force majeure,
and without the fault or negligence of the Party so failing or delaying. For
purposes of this Agreement, force majeure is defined as causes beyond the
control of the Party, including, without limitation, acts of God; acts,
regulations, or laws of any government; war; civil commotion; destruction of
production facilities or materials by fire, flood, earthquake, explosion or
storm; labor disturbances; epidemic; and failure of public utilities or common
carriers. In such event Encode or the Client, as the case may be, shall
immediately notify the other Party of such inability and of the period for which
such inability is expected to continue. The Party giving such notice shall
thereupon be excused from such of its obligations under this Agreement as it is
thereby disabled from performing for so long as it is so disabled and the 30
days thereafter. To the extent possible, each Party shall use reasonable efforts
to minimize the duration of any force majeure. Notwithstanding the foregoing,
this provision shall not excuse any obligation of either Party to make any
payment under this Agreement when due.

16.     SURVIVAL. The respective rights and obligations of the Parties hereto
contained in Sections 1.3, 2.2, 3.1, 4, 7, 8, 9, 10, 11, 12, 13, 19 and 24 shall
survive the expiration or earlier termination of this Agreement.

17.     INDEPENDENT CONTRACTOR. The relationship between Encode and the Client
is one of independent contractor and not one of partnership, principal and
agent, employer and employee, joint venturers or otherwise. Neither Party shall
have the power or right to bind or obligate the other.

18.     NOTICE. Any notice or other communication required or permitted to be
given under this Agreement shall be in writing and shall be deemed given on the
date actually received if delivered personally, by facsimile (receipt
confirmed), by e-mail (receipt confirmed) or if sent by overnight mail by a
courier guaranteeing overnight delivery (signature required). No notices or
other communications made pursuant to this Agreement shall be made via e-mail if
such notice or other communication contains any Confidential Information of
either Party. Notices and other communications to each of the Parties shall be
addressed to the Parties at the following addresses:


        If to Encode, to:

               Encode
               Geirsgotu 9, 101
               Reykjavik, Iceland
               Attention:    Thor Sigthorsson
                             cc: Hakon Hakonarson
               Tel:  354 510 9900
               Fax:  354 510 9901


                                      -14-
<PAGE>   16

               E-mail:  thor@encode.is
                        cc: hakonh@decode.is


        If to Client, to:

               Genmab A/S
               Bredgade 23, 3rd Floor
               1260 Copenhagen
               Denmark
               Attention: President
               Tel:  45 7020 2728
               Facsimile:  45 7020 2729
               E-mail: ldrakeman@aol.com


19.     GOVERNING LAW. This Agreement shall be construed under the laws of the
State of New Jersey without regard to principles of conflicts of law.

20.     SEVERABILITY. If one or more provisions of this Agreement shall be found
to be illegal or unenforceable in any respect, the validity, legality and
enforceability of the remaining provisions shall not in any way be affected or
impaired thereby, provided the surviving Agreement materially comports with the
original intent of the Parties.

21.     WAIVER. Waiver by either Party of any breach of this Agreement shall not
constitute a waiver of any subsequent breach of this Agreement.

22.     AMENDMENTS. This Agreement shall be modified or amended only by a
writing signed by the Parties.

23.     ASSIGNMENT. Except in connection with the transfer or sale by either
Party of all or substantially all of its assets to which this Agreement applies,
or the merger or consolidation of a Party hereto with a third party, this
Agreement may not be assigned by either Party without the prior written consent
of the other. In the event of a transfer, sale, merger, or consolidation in
which a Party hereto is not the surviving Party, this Agreement will be assigned
without modification to said Party's successor, and the Agreement shall continue
unaltered for its remaining term unless otherwise agreed upon between the
Parties at the time of any such occurrence.

24.     ARBITRATION. If a dispute shall arise between the Parties concerning
this Agreement, the Parties shall submit such dispute to binding arbitration by
a single arbitrator, who shall be appointed and act in accordance with the then
current commercial arbitration rules promulgated by the CPR Institute for
Dispute Resolution. Any such arbitration shall be conducted exclusively in New
York, New York. The decision of such arbitrator shall be in writing and shall be
final and binding upon the Parties.



                                      -15-
<PAGE>   17

25.     ENTIRE AGREEMENT. This Agreement constitutes the entire Agreement
between the Parties with respect to the subject matter hereof and supersedes all
prior negotiations, representations and agreements, oral or written, with
respect to the subject matter hereof. All of the terms and provisions of this
Agreement shall be binding upon, inure to the benefit of and be enforceable by
the Parties hereto and their respective permitted successors and assigns.

26.     COUNTERPARTS; FACSIMILE SIGNATURES. This Agreement may be executed in
two or more counterparts, each of which shall constitute an original document,
and all of which together shall constitute one and the same instrument. This
Agreement may be executed by facsimile signatures and such signatures shall be
deemed to bind each party hereto as if they were original signatures.

                                      * * *


                                      -16-
<PAGE>   18


    IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be
executed by its duly authorized representative as of the Effective Date.


Encode ehf.

        By:    /s/ Thor Sigthorsson
               ------------------------------------
        Name:  Thor Sigthorsson
        Title: Managing Director



Genmab A/S

        By:    /s/ Dr. Lisa N. Drakeman
               ------------------------------------
        Name:  Dr. Lisa N. Drakeman
        Title: Chief Executive Officer



        By:    /s/ Michael Wolff Jensen
               ------------------------------------
        Name:  Michael Wolff Jensen
        Title: Chief Financial Officer & Head of Legal Department



<PAGE>   19


                                   SCHEDULE A


CONTRACT INFORMATION
<TABLE>
<S>                       <C>
---------------------------------------------------------------------------------------------------------------------------
Description of Study      The study plan entitled "Pharmacogenomics of [**] and [**] Failures and HuMAX-CD4 Responders
Plan:                     and Diagnostic Tests" dated June 12, 2001 (the "Study Plan").
---------------------------------------------------------------------------------------------------------------------------
Services to be
Performed by Encode:      The drug studies as set forth in the Study Plan (the "Drug Studies").
---------------------------------------------------------------------------------------------------------------------------
Materials and             1.   [**] and [**] inhibitor and HuMAX-CD4 monoclonal antibody for in vitro studies.
Information to be         2.   Identification and enrollment of patient cohort for Part I CD4 Study.
provided by Client:       3.   Upon the occurrence of the Successful Completion of the Part I Subject Drug Study, as
                               such term is defined in the Drug Studies, identification and enrollment of patient cohort
                               for Part II Subject Drug Study.
                          4.   Upon the occurrence of the Successful Completion of the Part I CD4 Study, as such term
                               is defined in the Drug Studies, identification and enrollment of patient cohort for Part
                               II CD4 Study.
---------------------------------------------------------------------------------------------------------------------------
Deliverables of Encode:   1.   Diagnostic test for use in rheumatoid arthritis that separates Subject Drug therapy
                               non-responders with [**] or greater predictive accuracy ("Test A").
                          2.   Custom DNA array and protocol for performing Test A.
                          3.   Diagnostic test that separates HuMAX CD4 therapy responders with [**] or greater
                               predictive accuracy ("Test B").
                          4.   Custom DNA array and protocol for performing Test B.
---------------------------------------------------------------------------------------------------------------------------
Client's Principal
Scientist:
Address:
Facsimile:
---------------------------------------------------------------------------------------------------------------------------
Timeline for Completion   -    The Drug Studies will be completed in [**] months after study initiation with an
of Study:                      interim report after 6 months.
---------------------------------------------------------------------------------------------------------------------------
Fee, Payment and Cost     Fee: [**] for performance of the Drug Studies (see Budget attached to the Drug Studies for
Terms:                    detailed break down).  The following percentage of the Fee will be paid by Client upon the
                          occurrence of the following events: [**]

                              -


                          Cost: In addition to the Fee, up to a total of [**] will be paid by Client to reimburse Encode
                          for the actual cost of Affymetrix U95A gene chips as and when such costs are actually incurred
                          by Encode during the course of conducting the studies.
---------------------------------------------------------------------------------------------------------------------------
</TABLE>



<PAGE>   20


ACCEPTED AND AGREED TO:

Encode ehf.

        By:    /s/ Thor Sigthorsson
               ------------------------------------
        Name:  Thor Sigthorsson
        Title: Managing Director



Genmab A/S

        By:    /s/ Dr. Lisa N. Drakeman
               ------------------------------------
        Name:  Dr. Lisa N. Drakeman
        Title: Chief Executive Officer



        By:    /s/ Michael Wolff Jensen
               ------------------------------------
        Name:  Michael Wolff Jensen
        Title: Chief Financial Officer & Head of Legal Department



<PAGE>   21


                                   SCHEDULE B

CONTRACT INFORMATION

<TABLE>
<S>                    <C>
---------------------------------------------------------------------------------------------------------------------
Description of the     The target development plan entitled "Identification of Novel Therapeutic Targets in
Target Development     Rheumatoid Arthritis" dated June 12, 2001 (the "Target Development Plan").
Plan:
---------------------------------------------------------------------------------------------------------------------
Services to be
Performed by Encode:   The Target Development Study as set forth in the Target Development Plan (the "Target
                       Development Study")

---------------------------------------------------------------------------------------------------------------------
Materials and
Information to be
provided by Client:



---------------------------------------------------------------------------------------------------------------------
Deliverables:          1.   Candidate targets for therapeutic human monoclonal antibodies in RA based on gene
                            expression profiles, analysis of genetic association of SNP haplotypes for the
                            candidate targets in RA.

---------------------------------------------------------------------------------------------------------------------
Client's Principal
Scientist:

Address:



Facsimile:
---------------------------------------------------------------------------------------------------------------------
Timeline:              [**] months after identification of selected genes.


---------------------------------------------------------------------------------------------------------------------
Fee and Payment        Fee: $ [**] for performance of the Target Development Study.
Terms:
                          -   The following percentage of the Fee will be paid by Client upon the occurrence of
                              the following events:[**]



---------------------------------------------------------------------------------------------------------------------
</TABLE>




<PAGE>   22


ACCEPTED AND AGREED TO:

Encode ehf.

        By:    /s/ Thor Sigthorsson
               ------------------------------------
        Name:  Thor Sigthorsson
        Title: Managing Director



Genmab A/S

        By:    /s/ Dr. Lisa N. Drakeman
               ------------------------------------
        Name:  Dr. Lisa N. Drakeman
        Title: Chief Executive Officer



        By:    /s/ Michael Wolff Jensen
               ------------------------------------
        Name:  Michael Wolff Jensen
        Title: Chief Financial Officer & Head of Legal Department