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SECURITIES AND EXCHANGE COMMISSIONWASHINGTON, D.C. 20549

FORM 10-Q

|(Mark One) |                                                                                         
|---------- | ----------------------------------------------------------------------------------------
|ý          | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934.

FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2003

OR

|o                                                        | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934
|-------------------------------------------------------- | -----------------------------------------------------------------------------------------
|FOR THE TRANSITION PERIOD
FROM                        TO

COMMISSION FILE NUMBER 000-30469

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deCODE genetics, Inc.(Exact Name of Registrant as Specified in Its Charter)

|Delaware(State or Other Jurisdiction of
Incorporation or Organization) |  | 04-3326704(I.R.S. Employer
Identification No.)
|---------------------------------------------------------------------- |  | ----------------------------------------------

STURLUGATA 8, IS-101 REYKJAVIK, ICELAND(Address of Principal Executive Offices, Zip Code)

+354-570-1900(Registrant's Telephone Number, Including Area Code)

Indicate
by check whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding
12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days. Yes ý    No o

Indicate
by check whether the registrant is an accelerated filer (as defined in Rule 12b-2 of the Exchange
Act). Yes ý    No o

The
aggregate number of shares of the registrant's common stock outstanding on July 30, 2003 was 53,535,601 shares of common stock $.001 par value.

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deCODE genetics, Inc.

INDEX



|                  |  |                                                                                                                  |  | Page Number
|----------------- |  | ---------------------------------------------------------------------------------------------------------------- |  | -----------
|Part I.           |  | Financial Information                                                                                            |  | 2          
|Item 1.           |  | Financial Statements (unaudited)                                                                                 |  | 2          
|                  |  | Condensed Consolidated Statements of Operations for the three and six month periods ended June 30, 2003 and 2002 |  | 2          
|                  |  | Condensed Consolidated Balance Sheets as of June 30, 2003 and December 31, 2002                                  |  | 3          
|                  |  | Condensed Consolidated Statements of Cash Flows for the six-month periods ended June 30, 2003 and 2002           |  | 4          
|                  |  | Notes to Condensed Consolidated Financial Statements                                                             |  | 5          
|Item 2.           |  | Management's Discussion and Analysis of Financial Condition and Results of Operations                            |  | 14         
|Item 3.           |  | Quantitative and Qualitative Disclosures about Market Risk                                                       |  | 22         
|Item 4.           |  | Controls and Procedures                                                                                          |  | 23         
|Part II.          |  | Other Information                                                                                                |  | 25         
|Item 1.           |  | Legal proceedings                                                                                                |  | 25         
|Item 5.           |  | Other Information                                                                                                |  | 26         
|                  |  | Risk factors                                                                                                     |  | 26         
|Item 6.           |  | Exhibits and Reports on Form 8-K                                                                                 |  | 37         
|                  |  | (a) Exhibits                                                                                                     |  | 37         
|                  |  | (b) Reports on Form 8-K                                                                                          |  | 37         
|Signatures        |  | 38                                                                                                              
|Index to Exhibits |  | 39                                                                                                              

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PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

deCODE genetics, Inc.        CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS        (in thousands, except share and per share amounts)        unaudited

|                                                                    |                                                                     | For the Three Months
Ended June 30, |            | For the Six Months
Ended June 30, |       
|------------------------------------------------------------------- | ------------------------------------------------------------------- | ----------------------------------- | ---------- | --------------------------------- | ------
|
|Revenue                                                             |                                                                     | $                                   | 10,536     |                                   | $     
|Operating Expenses                                                  |                                                                     |                                     |            |                                   |       
|                                                                    | Research and development, including cost of revenue                 |                                     |            | 16,793                            |       
|                                                                    | Selling, general and administrative                                 |                                     |            | 3,713                             |       
|                                                                    | Employee termination costs                                          |                                     |            | 306                               |       
|                                                                    |                                                                     |                                     |            |                                   |       
|                                                                    |                                                                     | Total operating expense             |            |                                   | 20,812
|                                                                    |                                                                     |                                     |            |                                   |       
|Operating loss                                                      |                                                                     |                                     | (10,276    | )                                 |       
|Interest income                                                     |                                                                     |                                     | 299        |                                   |       
|Interest expense                                                    |                                                                     |                                     | (861       | )                                 |       
|Other non-operating income and (expense), net                       |                                                                     |                                     | 606        |                                   |       
|                                                                    |                                                                     |                                     |            |                                   |       
|Net loss before cumulative effect of change in accounting principle |                                                                     |                                     | (10,232    | )                                 |       
|Cumulative effect of change in milestone revenue recognition method |                                                                     |                                     | 0          |                                   |       
|                                                                    |                                                                     |                                     |            |                                   |       
|Net Loss                                                            |                                                                     | $                                   | (10,232    | )                                 | $     
|                                                                    |                                                                     |                                     |            |                                   |       
|Basic and diluted net loss per share:                               |                                                                     |                                     |            |                                   |       
|                                                                    | Net loss before cumulative effect of change in accounting principle |                                     | $          | (0.20                             | )     
|                                                                    | Cumulative effect of change in milestone revenue recognition method |                                     |            |                                  |       
|                                                                    | Net Loss                                                            |                                     |            | (0.20                             | )     
|Shares used in computing basic and diluted net loss per share       |                                                                     |                                     | 51,282,154 |                                   |       

The
accompanying notes are an integral part of the condensed consolidated financial statements.

2

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deCODE genetics, Inc.        CONDENSED CONSOLIDATED BALANCE SHEETS        (in thousands, except share amounts)        unaudited

|                                                                                                               |                                                                                                                                                                                                                                                                   | June 30,
2003                               |          | December 31,
2002 |        
|-------------------------------------------------------------------------------------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------- | -------- | ----------------- | -------
|Assets                                                                                                         |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|Current assets:                                                                                                |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               | Cash and cash equivalents                                                                                                                                                                                                                                         |                                             | $        | 70,641            |        
|                                                                                                               | Receivables                                                                                                                                                                                                                                                       |                                             |          | 7,489             |        
|                                                                                                               | Other current assets                                                                                                                                                                                                                                              |                                             |          | 6,965             |        
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   | Total current assets                        |          |                   | 85,095 
|Restricted cash                                                                                                |                                                                                                                                                                                                                                                                   |                                             | 6,000    |                   |        
|Property and equipment, net                                                                                    |                                                                                                                                                                                                                                                                   |                                             | 77,626   |                   |        
|Goodwill                                                                                                       |                                                                                                                                                                                                                                                                   |                                             | 8,863    |                   |        
|Other long-term assets and deferred charges                                                                    |                                                                                                                                                                                                                                                                   |                                             | 14,488   |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   | Total assets                                |          | $                 | 192,072
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|Liabilities and Stockholders' Equity                                                                           |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|Current liabilities:                                                                                           |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               | Accounts payable                                                                                                                                                                                                                                                  |                                             | $        | 3,681             |        
|                                                                                                               | Accrued expenses                                                                                                                                                                                                                                                  |                                             |          | 10,474            |        
|                                                                                                               | Current portion of capital lease obligations                                                                                                                                                                                                                      |                                             |          | 7,513             |        
|                                                                                                               | Current portion of long-term debt                                                                                                                                                                                                                                 |                                             |          | 4,582             |        
|                                                                                                               | Deferred revenue                                                                                                                                                                                                                                                  |                                             |          | 8,189             |        
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   | Total current liabilities                   |          |                   | 34,439 
|Capital lease obligations, net of current portion                                                              |                                                                                                                                                                                                                                                                   |                                             | 4,433    |                   |        
|Long-term debt, net of current portion                                                                         |                                                                                                                                                                                                                                                                   |                                             | 45,406   |                   |        
|Deferred revenue                                                                                               |                                                                                                                                                                                                                                                                   |                                             | 4,500    |                   |        
|Other long-term liabilities                                                                                    |                                                                                                                                                                                                                                                                   |                                             | 7        |                   |        
|Commitments and contingencies                                                                                  |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|Stockholders' equity:                                                                                          |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               | Preferred stock, $0.001 par value;
Authorized: 6,716,666 shares
Issued and outstanding: none                                                                                                                                                                      |                                             |          | 0                 |        
|                                                                                                               | Common stock, $0.001 par value;
Authorized: 100,000,000 shares;
Issued: 53,783,239 and 53,695,869 shares
at June 30, 2003 and December 31, 2002, respectively;
Outstanding: 53,535,168 and 53,545,234 shares
at June 30, 2003 and December 31, 2002, respectively |                                             |          | 54                |        
|Additional paid-in capital                                                                                     |                                                                                                                                                                                                                                                                   |                                             | 431,600  |                   |        
|Notes receivable                                                                                               |                                                                                                                                                                                                                                                                   |                                             | (6,976   | )                 |        
|Deferred compensation                                                                                          |                                                                                                                                                                                                                                                                   |                                             | (1,450   | )                 |        
|Accumulated deficit                                                                                            |                                                                                                                                                                                                                                                                   |                                             | (318,361 | )                 |        
|Accumulated other comprehensive income (loss)                                                                  |                                                                                                                                                                                                                                                                   |                                             | 0        |                   |        
|Treasury stock, 248,071 and 150,635 shares stated at cost at June 30, 2003 and December 31, 2002, respectively |                                                                                                                                                                                                                                                                   |                                             | (1,580   | )                 |        
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   | Total stockholders' equity                  |          |                   | 103,287
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        
|                                                                                                               |                                                                                                                                                                                                                                                                   | Total liabilities, and stockholders' equity |          | $                 | 192,072
|                                                                                                               |                                                                                                                                                                                                                                                                   |                                             |          |                   |        

The
accompanying notes are an integral part of the condensed consolidated financial statements.

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deCODE genetics, Inc.        CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS        (in thousands)        unaudited

|                                                                            |                                                                      | For the Six-Months Ended June 30,         |        
|--------------------------------------------------------------------------- | -------------------------------------------------------------------- | ----------------------------------------- | -------
|
|Cash Flows From Operating Activities:                                       |                                                                      |                                           |        
|Net loss                                                                    |                                                                      | $                                         | (23,274
|Adjustments to reconcile net loss to net cash used in operating activities: |                                                                      |                                           |        
|                                                                            | Depreciation and amortization                                        |                                           |        
|                                                                            | Purchased in-process research and development                        |                                           |        
|                                                                            | Equity in net earnings of affiliate                                  |                                           |        
|                                                                            | Amortization of deferred stock compensation                          |                                           |        
|                                                                            | Loss on disposal of equipment                                        |                                           |        
|                                                                            | Charges for write-down of obsolete and excess materials and supplies |                                           |        
|                                                                            | Unrealized gain on derivative financial instruments                  |                                           |        
|                                                                            | Other                                                                |                                           |        
|Changes in operating assets and liabilities net of effect of acquisition:   |                                                                      |                                           |        
|                                                                            | Receivables and other assets                                         |                                           |        
|                                                                            | Accounts payable and accrued expenses                                |                                           |        
|                                                                            | Deferred research revenue                                            |                                           |        
|                                                                            | Other                                                                |                                           |        
|                                                                            |                                                                      |                                           |        
|                                                                            |                                                                      | Net cash used in operating activities     |        
|                                                                            |                                                                      |                                           |        
|Cash Flows From Investing Activities:                                       |                                                                      |                                           |        
|                                                                            | Purchase of property and equipment                                   |                                           |        
|                                                                            | Proceeds from sale of property and equipment                         |                                           |        
|                                                                            | Cash acquired in purchase of MediChem, net of transaction costs      |                                           |        
|                                                                            |                                                                      |                                           |        
|                                                                            |                                                                      | Net cash used in investing activities     |        
|                                                                            |                                                                      |                                           |        
|Cash Flows From Financing Activities:                                       |                                                                      |                                           |        
|                                                                            | Proceeds from financing of property and equipment                    |                                           |        
|                                                                            | Repayment of mortgage                                                |                                           |        
|                                                                            | Issuance of common stock                                             |                                           |        
|                                                                            | Repayment of notes receivable for common stock                       |                                           |        
|                                                                            | Installment payments on debt and capital lease obligations           |                                           |        
|                                                                            |                                                                      |                                           |        
|                                                                            |                                                                      | Net cash provided by financing activities |        
|                                                                            |                                                                      |                                           |        
|Net decrease in cash                                                        |                                                                      |                                           | (16,603
|Cash and cash equivalents at beginning of period.                           |                                                                      |                                           | 87,244 
|                                                                            |                                                                      |                                           |        
|Cash and cash equivalents at end of period                                  |                                                                      | $                                         | 70,641 
|                                                                            |                                                                      |                                           |        

The
accompanying notes are an integral part of the condensed consolidated financial statements.

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deCODE genetics, Inc.  NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS(tabular amounts in thousands, except share and per share amounts)

The Company

References in this report to deCODE and "we" and "us" refer to deCODE genetics, Inc., a Delaware company, and deCODE genetics, Inc.'s wholly owned
subsidiary, Islensk erfdagreining ehf., an Icelandic company registered in Reykjavik, and its subsidiaries Encode ehf., deCODE Cancer ehf. and Vetrargardurinn ehf. as well as deCODE
genetics, Inc.'s wholly owned subsidiary, MediChem Life Sciences, Inc., a Delaware corporation, and its subsidiaries MediChem Research, Inc., ThermoGen, Inc., Emerald
BioStructures, Inc., Advanced X-Ray Analytical Services, Inc. and MediChem Management, Inc.

With
its headquarters in Reykjavik, Iceland, deCODE is a population genetics company developing drugs and DNA-based diagnostics based upon its discoveries in the inherited
causes of common diseases. deCODE's population approach and resources have enabled it to isolate gene and targets directly involved in the development of many diseases posing significant challenges to
public health and deCODE is focused on turning these findings into a pipeline of products. deCODE's customers include major pharmaceutical companies, biotechnology firms, pharmacogenomics companies,
universities and other research institutions. deCODE's business is global, with its principal markets in the United States and in Europe.

In
March 2002, deCODE completed the acquisition of MediChem Life Sciences, Inc. (MediChem) in a stock-for-stock exchange accounted for as a purchase
transaction. The acquisition gives deCODE capabilities in chemistry and structural proteomics that can be used in the implementation of its strategy of turning its targets identified by applying
population genomics to common diseases into novel drugs for the market both through its own programs and in alliances with collaborators. Founded in 1987, MediChem (now our pharmaceuticals and
biostructures groups) provides contract chemistry research services specializing in chemical synthesis for new drug discovery and development for the global pharmaceutical, biotechnology,
agricultural, chemical and personal care industries.

deCODE's
operations are in a single business segment, primarily focused on developing products and services for the healthcare industry from its population-based gene discovery work in
Iceland. To date, deCODE's revenues have been largely derived from services provided, including product development service activities. Broadening that discovery work to development of products,
deCODE is organized according to product development offerings and services. deCODE's product development activities encompass the discovery and commercialization of novel therapeutics designed
against targets identified in deCODE's gene discovery work, as well as the creation of DNA-based diagnostic and pharmacogenomic tests and the development of software systems for making
correlations between genetic variation and disease and drug response. deCODE's service offerings include contract service businesses in drug discovery and medicinal chemistry through its Chicago-based
pharmaceuticals group, three-dimensional protein crystallography products and contract services through its Seattle-based biostructures group, pharmacogenomics and clinical trials services through its
wholly-owned subsidiary Encode, genotyping services carried out in Reykjavik, Iceland and bioinformatics services and tools developed in the course of deCODE's gene and drug target research.

Basis of Presentation

The unaudited condensed consolidated financial statements included herein have been prepared by deCODE, pursuant to the rules and regulations of the Securities
and Exchange Commission. Certain information and disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States of
America have been condensed or omitted pursuant to such rules and regulations. The condensed consolidated balance sheet as of

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December 31,
2002 has been derived from the audited financial statements as of that date, but does not include all disclosures required by accounting principles generally accepted in the United
States. deCODE believes the disclosures included in the condensed consolidated financial statements when read in conjunction with the financial statements and the notes thereto included in deCODE's
Annual Report on Form 10-K are adequate to make the information presented not misleading.

Certain
reclassifications have been made in the December 31, 2002 balance sheet to be consistent with the June 30, 2003 presentation. These financial statements are
reported in United States dollars, deCODE's functional currency. Tabular amounts are stated in thousands, except share and per share amounts.

The
condensed consolidated financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which
include only normal recurring adjustments, necessary for a fair presentation of deCODE's financial position, results of operations and cash flows for the periods presented. The results of operations
for the three and six month periods ended June 30, 2003 and 2002 are not necessarily indicative of the results that may be expected for any other interim period or for the full fiscal year.

Principles of Consolidation

The unaudited condensed consolidated financial statements include the accounts and operations of deCODE genetics, Inc. and its wholly owned subsidiaries.
All significant intercompany accounts and transactions are eliminated upon consolidation. Investments in which deCODE has significant influence, but does not control, are accounted for using the
equity method.

Use of Estimates

The preparation of the unaudited condensed consolidated financial statements in conformity with accounting principles generally accepted in the United States of
America requires management to make certain estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the
financial statements and the reported amounts of revenues and expenses during the reported period. On an ongoing basis we evaluate our estimates, which include, among others, those related to
collaborative arrangements, property and equipment, materials and supplies, income taxes, litigation and other contingencies, materials and supplies, derivatives, intangible assets, and bad debts. We
base our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances, the results of which form our basis for making judgments about
carrying values of assets and liabilities that are not readily apparent from other sources. Actual results could differ from those estimates.

Revenue Recognition and Deferred Revenue

Revenues from research and development collaboration agreements are recorded and recognized in accordance with the applicable performance requirements and terms
of the respective contracts, generally either (i) as contract research costs are incurred, usually ratably over the period of effort, (ii) according to the percentage of completion
method of contract accounting based on the ratio of costs incurred to expected total costs, or (iii) upon the achievement of substantive milestones, that is where the milestone event is
substantive, there is substantial effort involved in achieving the milestone, the milestone payment amount is commensurate with the magnitude of the related achievement, and the associated
follow-on revenue streams bear a reasonable relationship to one another. Milestone payments without these characteristics are recognized on a retrospective basis over the contractual term
of the underlying agreement. Funding payments are not refundable in the event that the related efforts are not successful. Non-refundable, up-front payments are deferred and
recognized on a straight-line basis over the contract term. Contracted chemistry services revenue from negotiated rate contracts are

6

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recognized
on a per diem basis as services are rendered or on the percentage of completion method based on the ratio of costs incurred to expected total costs for fixed fee contracts based upon the
terms of the underlying contract. Any losses on contracts are provided for when they are determinable. Included in revenue are billings to customers for the cost of materials purchased by deCODE.

In
general, prerequisites for billings are established by contractual terms including predetermined payment schedules, the achievement of contract milestones, or submission of
appropriate billing detail. Revenue recorded represents amounts billed in accordance with contractual terms. Unbilled costs and fees arise when revenue has been recognized but customers have not been
billed. Contractual payments due to deCODE are recorded as deferred revenue until earned. The following is a summary of deferred revenue:

|                                                                    |  | For the Three Months
Ended June 30, |         | For the Six Months
Ended June 30, |  
|------------------------------------------------------------------- |  | ----------------------------------- | ------- | --------------------------------- | -
|
|
|Revenue recorded during the period                                  |  | $                                   | 10,466  |                                   | $
|Revenue recognized during the period                                |  |                                     | (10,536 | )                                 |  
|Deferred revenue recorded on acquisition of MediChem                |  |                                     | 0       |                                   |  
|Cumulative effect of change in milestone revenue recognition policy |  |                                     | 0       |                                   |  
|                                                                    |  |                                     |         |                                   |  
|                                                                    |  |                                     | (70     | )                                 |  
|Deferred revenue at beginning of period                             |  |                                     | 12,759  |                                   |  
|                                                                    |  |                                     |         |                                   |  
|Deferred revenue at end of period                                   |  | $                                   | 12,689  |                                   | $
|                                                                    |  |                                     |         |                                   |  

Roche
accounted for 39% and 40% of consolidated revenue in three-month periods ended June 30, 2003 and 2002, respectively. Roche accounted for 42% and 55% of consolidated revenue
in six-month periods ended June 30, 2003 and 2002, respectively. Merck accounted for 18% and 16% of consolidated revenue in the three and six-month period ended
June 30, 2003, respectively. Revenue for the six-month periods ended June 30, 2003 and 2002 includes $7,000 and $46,000, respectively, in services provided to Prokaria, a
related party.

Stock-Based Compensation and Remuneration

deCODE follows Statement of Financial Accounting Standards No. 123 (SFAS No. 123), Accounting for Stock-Based Compensation. The provisions of SFAS
No. 123 allow companies to either expense the estimated fair value of stock options granted to employees or to follow the intrinsic value method set
forth in Accounting Principles Board Opinion No. 25 (APB No. 25), Accounting for Stock Issued to Employees, and disclose the pro forma effects on net loss and net loss per share had the
estimated fair value of the options granted to employees been expensed. SFAS No. 123 requires companies to expense the estimated fair value of stock options granted to
non-employees. deCODE has elected to follow the intrinsic value method in accounting for its employee stock options and follows the fair value method in accounting for its
non-employee stock options.

Stock-based
compensation represents the expense charged in the statements of operations relating to employee and non-employee stock options granted. Stock-based remuneration
represents the expense charged in the statements of operations relating to shares of stock issued to non-employees in

7

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exchange
for services provided. Stock-based compensation and remuneration are included in the condensed consolidated statements of operations in the following captions:

|                                             |  | For the Three Months
Ended June 30, |     | For the Six Months
Ended June 30,
|-------------------------------------------- |  | ----------------------------------- | --- | ---------------------------------
|
|
|Research and development expense             |  | $                                   | 314 |                                  
|Selling, general and administrative expense. |  |                                     | 232 |                                  
|                                             |  |                                     |     |                                  
|Total                                        |  | $                                   | 546 |                                  
|                                             |  |                                     |     |                                  

Had
compensation cost for all stock options been determined based on the fair value at the grant date for awards consistent with the provisions of SFAS No. 123, as amended by SFAS
No. 148, "Accounting for Stock-Based CompensationTransition and Disclosurean amendment of FASB Statement No. 123" ("SFAS 148"), deCODE's net loss and
basic and diluted net loss per share would have been changed to the pro forma amounts indicated below:

|                                                                                                          |  | For the Three Months
Ended June 30, |         | For the Six Months
Ended June 30, |  
|--------------------------------------------------------------------------------------------------------- |  | ----------------------------------- | ------- | --------------------------------- | -
|
|
|Net loss attributable to common stockholdersas reported                                                  |  | $                                   | (10,232 | )                                 | $
|Add: Stock-based employee compensation expense included in reported net loss                              |  |                                     | 546     |                                   |  
|Deduct: Total stock-based employee compensation expense determined under fair value method for all awards |  |                                     | (1,407  | )                                 |  
|                                                                                                          |  |                                     |         |                                   |  
|Net loss attributable to common stockholderspro forma                                                    |  | $                                   | (11,093 | )                                 | $
|                                                                                                          |  |                                     |         |                                   |  
|Basic and diluted net loss per shareas reported                                                          |  | $                                   | (0.20   | )                                 | $
|Basic and diluted net loss per sharepro forma                                                            |  |                                     | (0.22   | )                                 |  

The
effects of applying the provisions of SFAS No. 123 on net loss and net loss per share as stated above is not necessarily representative of the effects on reported income or
loss for future years due to, among other things, the vesting period of the stock options and the fair value of additional stock options that may be granted in future years.

In
May 2003, deCODE granted options to purchase 633,400 shares of common stock to employees under the 1996 Equity Incentive Plan.

Computation of Net Loss Per Common Share

Basic net loss per share is computed using net loss available to common stockholders and the weighted-average number of common shares outstanding. The
weighted-average number of common shares outstanding during the period is the number of shares determined by relating the portion of time within a reporting period that common shares have been
outstanding to the total time in that period.

Diluted
net loss per share is computed using the weighted-average number of common shares outstanding during the period, plus the dilutive effect of potential common shares. Diluted net
loss per share does not differ from basic net loss per share in all periods presented as potential common shares are antidilutive for all such periods and are, therefore, excluded from the
calculation. Potential

8

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common
shares excluded from the calculation of diluted net loss per share as their inclusion would have been antidilutive were:

June 30,2003

2002(shares)Warrants to purchase shares of common stock

1,851,300

1,851,300Options to purchase shares of common stock

2,288,000

2,554,270Restricted shares with an associated outstanding non-recourse promissory note

2,226,622

3,359,794


Comprehensive Income (Loss)

Comprehensive income (loss) generally represents all changes in stockholders' equity except those resulting from investments or contributions by stockholders.
Amounts reported in other comprehensive income (loss) include foreign currency translation adjustments. The following table presents the calculation of comprehensive income:

|                                   |                              | For the Three Months
Ended June 30, |         | For the Six Months
Ended June 30, |  
|---------------------------------- | ---------------------------- | ----------------------------------- | ------- | --------------------------------- | -
|
|
|Net loss                           |                              | $                                   | (10,232 | )                                 | $
|Other comprehensive income (loss): |                              |                                     |         |                                   |  
|                                   | Foreign currency translation |                                     |         | (2                                | )
|                                   |                              |                                     |         |                                   |  
|Total comprehensive income (loss)  |                              | $                                   | (10,234 | )                                 | $
|                                   |                              |                                     |         |                                   |  

Employee Termination Benefits

In September of 2002, deCODE implemented a cost reduction program including charges related to termination benefits for 132 employees. Of the $2,158,000 then
provided, $1,284,000 was paid in 2002 and $874,000 remained accrued and unpaid as of December 31, 2002. Charges for termination benefits for 27 additional employees were added ($485,000) and
total termination benefits of $1,155,000 were paid in the three-months ended March 31, 2003. Charges for termination benefits for 17 additional employees were added ($306,000) and total
termination benefits of $219,000 were paid in the three-months ended June 30, 2003 leaving $291,000 accrued and unpaid as of June 30, 2003. Termination benefits remaining accrued and
unpaid as of June 30, 2003 (17 employees) are expected to be settled in cash over the next six months.

Recent Collaborations

Merck.In September 2002, deCODE and Merck & Co., Inc. (Merck) entered into an alliance aimed at
developing new treatments for obesity. Under the alliance, deCODE and Merck will combine their research efforts in the genetics of obesity to identify, validate and prioritize a series of drug targets
to take into development. Under the terms of the three-year agreement, deCODE will receive research funding, technology access fees, license fees, milestone payments as compounds developed
under the alliance advance in the development process, and royalties on successfully marketed alliance drugs.

IBM.In January 2003, deCODE announced a three-year strategic alliance with IBM under which deCODE and IBM
will jointly market and sell deCODE's Clinical Genome Miner (CGM) Discovery(TM) system running on IBM hardware and software. CGM Discovery(TM) is the same statistically-based application for isolating
and analyzing genes and gene variations associated with

9

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particular
diseases that deCODE has used its gene discovery programs. The alliance aims to take advantage of deCODE's expertise in genetics and IBM's leadership in hardware and software systems to
create solutions for what deCODE and IBM believe is a growing market for information-based medicine.

Wyeth.In November 2002, deCODE entered into a pharmacogenomics alliance with Wyeth. Under the agreement, deCODE will
use its in vitro pharmacogenomics expertise to generate gene expression data for a drug candidate targeted to treatment of certain respiratory diseases.

Vertex Pharmaceuticals.In January 2003 deCODE announced an agreement with Vertex Pharmaceuticals under which we will
gather and analyze pharmacogenomic data as part of clinical trials our subsidiary Encode conducts on Vertex developmental compounds. The first project under the agreement is a phase IIa clinical trial
for Vertex's VX-148 treatment for psoriasis. Our pharmacogenomics capabilities will enable Vertex to gain an understanding, in conjunction with clinical trial results, of genetic factors
affecting the responses of individuals to treatment. This information may be useful in designing subsequent clinical strategies and pharmacogenomic tests. Based upon the results of work under this
agreement, the parties may extend the collaboration to the development and commercialization of pharmacogenomic tests.

Families
of Spinal Muscular Atrophy. In February 2003, deCODE and Families of Spinal Muscular Atrophy (FSMA), an organization founded to promote research leading to the effective
treatment of this debilitating and often fatal disease, announced the signing of an agreement aimed at developing a new therapeutic compound for spinal muscular atrophy. Using promising compounds
identified through previous FSMA-funded gene- and drug-discovery work, deCODE's Chicago-based pharmaceuticals group will identify the most promising lead compounds,
optimize these compounds, and conduct the medicinal chemistry and scale-up work to develop a potentially effective new drug ready for clinical trials. The three-year agreement
is potentially worth $5.2 million, including milestones for the successful development of a compound approved for clinical trials.

Derivative Financial Instruments

During the normal course of business, deCODE is exposed to foreign currency risk and interest rate risk. These risks can create volatility in earnings and cash
flows from period to period. deCODE's objective is to reduce volatility of earnings and cash flows associated with market risks. Derivative
instruments held by the Company are used for hedging and non-speculative purposes. As of June 30, 2003, deCODE maintains two cross-currency swaps for purposes of managing certain of
these risks.

deCODE
seeks to maintain a desired level of floating-rate debt with respect to its overall debt portfolio denominated in U.S. Dollars. To this end, deCODE uses interest rate
and cross-currency swaps to manage interest rate and foreign currency risk arising from long-term debt obligations denominated in Icelandic krona. These interest rate and cross-currency
swaps with a remaining combined notional amount of 1,930 million Icelandic krona (approximately $25 million at June 30, 2003) are designated as economic hedges of fixed rate
foreign currency debt (Tier A and Tier C bonds), but do not qualify for hedge accounting under SFAS 133. The estimated fair value of these instruments is included in other long-term
assets is $9,193,000 and $6,361,000 as of June 30, 2003 and December 31, 2002, respectively. The unrealized gain for the three-month periods ended June 30, 2003 and 2002 resulting from
the recording of these instruments together with the translation of the Tier A and Tier C bonds is $960,000 and $1,073,000, respectively, and for the six-month periods ended
June 30, 2003 and 2002 is $1,163,000 and $1,327,000, respectively, and is included in other non-operating income and (expense), net in the Consolidated Statements of Operations.

The
fair value of derivative instruments is sensitive to movements in the underlying market rates and variables. deCODE monitors the fair value of derivative instruments on a periodic
basis. Fair

10

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values
are estimated for each derivative using common market valuation methods with reference to available market data as of the balance sheet date.

Debt

In June 2003, deCODE sold certain laboratory equipment for $4,750,000 net cash proceeds and leased the equipment back from the counter-party (an Icelandic
leasing company) for an 18-month term. As ownership of the equipment will be transferred to deCODE at the end of the lease without any further significant payment, the transaction has been
recorded as a financing and no immediate gain was recognized.

Guarantees

Under its bylaws, deCODE has agreed to indemnify its officers and directors for certain events or occurrences while the officer or director is, or was serving, at
its request in such capacity. The term of the indemnification period is for the officer's or director's lifetime. deCODE has a separate
indemnification agreement with one of its directors that requires it, subject to certain exceptions, to indemnify him to the fullest extent authorized or permitted by its bylaws and the Delaware
General Corporation Law. The maximum potential amount of future payments deCODE could be required to make under these indemnification agreements is unlimited; however, deCODE has a directors and
officer liability insurance policy that limits its exposure and enables it to recover a portion of any future amounts paid. As a result of its insurance policy coverage, deCODE believes the estimated
fair value of these indemnification agreements is minimal. deCODE has no liabilities recorded for these agreements as of June 30, 2003.

When
as part of an acquisition deCODE acquires all of the stock or all of the assets and liabilities of a company, it assumes the liability for certain events or occurrences that took
place prior to the date of acquisition. The maximum potential amount of future payments it could be required to make for such obligations is undeterminable at this time. deCODE has no liabilities
recorded for these liabilities as of June 30, 2003.

deCODE
enters into indemnification provisions under (i) its agreements with other companies in its ordinary course of business, typically with business partners, contractors,
clinical sites and customers and (ii) its agreements with investors. Under these provisions deCODE generally indemnifies and hold harmless the indemnified party for losses suffered or incurred
by the indemnified party as a result of deCODE's activities or, in some cases, as a result of the indemnified party's activities under the agreement. These indemnification provisions generally survive
termination of the underlying agreement. In addition, in some cases, deCODE has agreed to reimburse employees for certain expenses and to provide salary continuation during short-term
disability. The maximum potential amount of future payments deCODE could be required to make under these indemnification provisions is unlimited. deCODE has not incurred material costs to defend
lawsuits or settle claims related to these indemnification agreements. As a result, the estimated fair value of these agreements is minimal. Accordingly, deCODE has no liabilities recorded for these
agreements as of June 30, 2003.

Litigation

Other than claims and legal proceedings that arise from time to time in the ordinary course of its business which are not matieral, deCODE has no pending legal
proceedings except as follows:

In
February 2000, Mannvernd, an organization known as the Association of Icelanders for Ethics in Science and Medicine, issued a press release announcing its intention to file
lawsuits against the State of Iceland and any other relevant parties, including us, to test the constitutionality of the Act. In its press release, Mannvernd indicated that it hopes to halt the
construction and/or operation of the Icelandic Health Sector Database. In April 2001, a lawsuit was filed against the Icelandic Directorate of

11

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Public
Health but Mannvernd has not commenced litigation against us. The ultimate resolution of this matter cannot yet be determined.

On
or about April 20, 2002, an amended class action complaint, captioned In re deCODE genetics, Inc. Initial Public Offering Securities Litigation (01 Civ. 11219(SAS)),
alleging violations of federal securities laws was filed in the United States District Court for the Southern District of New York on behalf of certain purchasers of deCODE common stock. The complaint
names us, two of our current executive officers (the "Individual Defendants"), and the two lead underwriters (the "Underwriter Defendants") for our initial public offering in July 2000 (the
"IPO") as defendants.

In
the amended pleading, the plaintiff alleges violations of Section 11 of the Securities Act of 1933 and violations of Section 10(b) of the Securities Exchange Act of 1934
(and Rule 10b-5 promulgated thereunder) against us, the Individual Defendants and the Underwriter Defendants. In addition, the amended complaint alleges violations of
Section 15 of the Securities Act of 1933, and Section 20(a) of the Securities Exchange Act of 1934 against the Individual Defendants. Generally, the amended complaint alleges that the
Underwriter Defendants: (i) solicited and received excessive and undisclosed commissions from certain investors in exchange for which the Underwriter Defendants allocated to those investors
material portions of the shares of our stock sold in the IPO; (ii) entered into agreements with customers whereby the Underwriter Defendants agreed to allocate shares of our stock sold in the
IPO to those customers in exchange for which the customers agreed to purchase additional shares of our stock in the aftermarket at pre-determined prices; and (iii) improperly used
their analysts, who purportedly suffered from conflicts of interest, to manipulate the market. The amended complaint further alleges that the prospectus incorporated into the registration statement
for the IPO was materially false and misleading in that it failed to disclose these arrangements. The amended complaint also alleges that we and the Individual Defendants had numerous interactions and
contacts with the Underwriters from which we and the Individual Defendants either knew of, or recklessly disregarded, the Underwriters' purported wrongful acts. The suit seeks unspecified monetary and
recissionary damages and certification of a plaintiff class consisting of all persons who purchased shares of our common stock from July 17, 2000 to December 6, 2000.

We
are aware that similar allegations have been made in hundreds of other lawsuits filed (many by some of the same plaintiff law firms) against numerous underwriter defendants and issuer
companies (and certain of their current and former officers) in connection with various public offerings conducted in recent years. All of the lawsuits that have been filed in the Southern District of
New York have been consolidated for pretrial purposes before Honorable Judge Shira Scheindlin. Pursuant to the underwriting agreement executed in connection with our IPO, we have demanded
indemnification from
the Underwriter Defendants. The Underwriter Defendants have asserted that our request for indemnification is premature.

Pursuant
to an agreement the Individual Defendants have been dismissed from the case without prejudice. Along with numerous other issuers, we moved to dismiss the complaint for failure
to state a claim. On February 19, 2003, Judge Scheindlin granted our motion with respect to the Section 10(b) claims and denied the motion with respect to the Section 11 claims.

On
July 31, 2003, our Board of Directors (other than Dr. Stefansson) conditionally approved a proposed partial settlement with the plaintiffs in this matter. The settlement
would provide, among other things, a release of deCODE and of the Individual Defendants for the conduct alleged in the amended complaint to be wrongful. We would agree to undertake other
responsibilities under the partial settlement, including agreeing to assign away, and not assert or release, certain potential claims we may have against our underwriters. Any direct financial impact
of the proposed settlement is expected to be borne by our insurers. The Board agreed to approve the settlement subject to a number of conditions, including the participation of a substantial number of
other issuer defendants in the proposed settlement, the consent of our insurers to the settlement, and the completion of acceptable

12

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final
settlement documentation. Furthermore, the settlement is subject to a hearing on fairness and approval by the Court overseeing the litigation.

Due
to the inherent uncertainties of litigation and the fact that the settlement is in its early stages, the ultimate outcome of this matter cannot be predicted. If the settlement is not
consummated, we expect to contest the allegations against us and our officers vigorously. If we were required to pay significant monetary damages as a result of such litigation (or any other lawsuits
alleging similar claims filed against us and our officers in the future), our business could be significantly harmed. Even if such suit concludes in our favor, we may be required to expend significant
funds to defend against the allegations. We are unable to estimate the range of possible loss from the litigation and no amounts have been provided for such matters in our financial statements.

Recent Accounting Pronouncements

In January 2003, the FASB issued FASB Interpretation No. 46 ("FIN 46"), "Consolidation of Variable Interest Entities, an Interpretation of ARB
No. 51." FIN 46 requires certain variable interest entities to be consolidated by the primary beneficiary of the entity if the equity investors in the entity do not have the characteristics of
a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other parties. FIN 46 is
effective for all new variable interest entities created or acquired after January 31, 2003. For variable interest entities created or acquired prior to February 1, 2003, the provisions
of FIN 46 must be applied for the first interim or annual period beginning after June 15, 2003. deCODE adopted this
standard on July 1, 2003 and its adoption did not have a material impact on deCODE's financial position or results of operations.

In
November 2002, the Emerging Issues Task Force reached a consensus on Issue No. 00-21 ("EITF 00-21"), "Revenue Arrangements with Multiple
Deliverables." EITF 00-21 provides guidance on how to account for arrangements that involve the delivery or performance of multiple products, services and/or rights to use assets. The
provisions of EITF 00-21 will apply to revenue arrangements entered into in fiscal periods beginning after June 15, 2003. deCODE is evaluating the potential impact of EITF
00-21 on its financial position and results of operations.

In
April 2003, the Financial Accounting Standards Board (FASB) released Statement of Financial Accounting Standards (SFAS) No. 149, "Amendment of Statement 133 on Derivative
Instruments and Hedging Activities." SFAS No. 149 clarifies under what circumstances a contract with an initial net investment meets the characteristics of a derivative, amends the definition
of an underlying contract, and clarifies when a derivative contains a financing component in order to increase the comparability of accounting practices under SFAS No. 133. The statement is
effective for contracts entered into or modified after June 30, 2003, and for hedging relationships designated after June 30, 2003. The adoption of SFAS No. 149 is not expected to
have a material impact on the deCODE's financial position or results of operations.

In
May 2003, the FASB issued SFAS No. 150, "Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity." This Statement establishes
standards for how an issuer classifies and measures certain financial instruments with characteristics of both liabilities and equity. It requires that an issuer classify a financial instrument that
is within its scope as a liability (or an asset in some circumstances). Many of those instruments were previously classified as equity. The Statement is effective for financial instruments entered
into or modified after May 31, 2003. deCODE adopted this standard on June 1, 2003 and its adoption did not have any impact on deCODE's financial position or results of operations.

13

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Item 2. Management's Discussion and Analysis of Financial Condition and Results of Operations. (Tabular Amounts in Thousands, Except Share and Per Share Amounts)

This Management's Discussion and Analysis of Financial Condition and Results of Operations as of June 30, 2003 and for the three and six month periods
ended June 30, 2003 and 2002 should be read in conjunction with the unaudited condensed consolidated financial statements and notes thereto set forth in Item 1 of this report.

Overview

We are a population genetics company developing drugs and DNA-based diagnostics based upon our discoveries in the inherited causes of common diseases.
Our population approach and resources have enabled us to isolate genes and targets directly involved in the development of many of the most common diseases. We are focused on turning these findings
into a growing pipeline of products and services which we believe will be able to combat the causes of disease, not just the signs and symptoms. Our approach to the discovery of healthcare knowledge
brings together three key types of non-personally identifiable data derived from our population research in Iceland: genotypic data and disease data from more than 90,000 volunteer
participants in some 50 disease gene research programs, and genealogical data linking together the entire present-day population of Iceland and going back to the settlement of the country
in the ninth century.

Our
business strategy is to leverage our capabilities and assets to create product-driven value streams from the near through to the longer term. Our business is divided into two
components: products and services. Our primary product focus is on the discovery and commercialization of novel therapeutics designed against targets identified in our population-based gene discovery
work. Through the acquisition in March 2002 of MediChem Life Sciences and its subsidiary Emerald Biostructures, now our pharmaceuticals and biostructures groups, we have integrated capabilities
for applying genetic findings to the development of drugs both through our own programs and in alliance with our corporate partners. Our product development activities also encompass the creation of
new DNA-based diagnostics and pharmacogenomics tests, as we apply the links we have identified between genetic variation and disease, and genetic variation and drug response. We believe
such tests will become a standard part of healthcare, making it possible to gauge individual predisposition to a particular disease and to design effective preventive strategies; to complement
traditional clinical diagnoses; and to identify patients who are likely to respond or not respond to particular drugs. We are also marketing bioinformatics software systems developed in the course of
our gene and drug target research for making correlations between genetic variation and disease and drug response.

Our
services include pharmacogenetics and clinical trial services offered through our wholly-owned subsidiary Encode; contract services in structural biology, medicinal chemistry and
scale up into the clinic conducted by our pharmaceuticals group based in Chicago; database services, through subscriptions to our Clinical Genome Miner system, integrating anonymized population data
with data on disease, genotypes and genealogy; and genotyping services through our laboratory in Reykjavik.

We
have incurred losses since our inception, principally as a result of research and development and general and administrative expenses in support of our operations. As of
June 30, 2003 we had an accumulated deficit of $318.4 million. On the basis of our current range of activities, and following the implementation in September 2002 of a plan to
reduce costs and maximize the use of automation in our core genetics operations, we anticipate that we will be able to achieve positive cash flow from operations by the end of 2003. At the same time,
we believe that the initiation of substantial new activities within this timeframe would require additional expenditures that could delay for some time our achievement of positive cash flow from
operations. For example, in our target discovery work on our findings in myocardial infarction and hypertension, we believe we may be able to bypass much of the drug discovery process and enter
directly into phase II clinical trials in 2004. We anticipate

14

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incurring
additional net losses at least through the next two years, due to, among other factors, depreciation and amortization, as well as stock-based compensation and other non-cash
charges. We expect that our revenues and losses will fluctuate from quarter to quarter and that such fluctuations may be substantial, especially because progress in our scientific work and milestone
payments that are related to progress can fluctuate between quarters. We do not believe that comparisons of our quarter-to-quarter performance are a good indication of future
performance.

We
believe that current conditions in the global financial markets and in the pharmaceutical industry pose significant near-term challenges to biotechnology companies such as
ourselves, as well as important opportunities. The principal challenge to us posed by the downturn in the market valuations of biotechnology companies and of the equity markets more generally over the
past three years is that it restricts our present ability to raise additional capital on favorable terms. In a very broad sense, it appears that the equity markets continue to be more
risk-averse than they have been in the past. The markets are therefore less willing to ascribe value to companies such as ourselves which, although developing new technologies that may
have the potential for generating successful products, are still considered early-stage and are not yet profitable. This is a general trend affecting not only the biotechnology industry but all
industries involved in developing new technologies and products that are unproven in the marketplace. Moreover, it is not certain how long this sentiment in the equity markets will last.

In
order to mitigate the risk to our product development programs posed by the current conditions in the financial markets, we have implemented measures aimed at preserving our cash
resources. We have implemented a plan to reduce costs to a level that the we anticipate will make it possible to achieve positive cash flow from operations by the end of 2003. We believe that we have
sufficient cash
resources to continue to fund our current research and operations for several years, and we are also investigating the possibility of alternative avenues of financing for our product development
programs.

At
the same time, the pharmaceutical industry, which is the principal customer base for our gene-discovery and contract chemistry businesses, is experiencing difficulties in
maintaining historical rates of growth. This presents near-term challenges and significant longer-term opportunities. One of the main challenges facing the pharmaceutical
industry is developing pipelines of effective new drugs to treat major indications. As many leading brand-name drugs come off patent and face generic competition, developing successful new
medicines will become critical for filling the gap. In the short term, the financial pressures on pharmaceutical companies may be reflected in their research and development spending, making it more
difficult for us to sign corporate alliances with significant upfront funding, or lengthening the time required to negotiate such deals. This will likely also lead to pressure on budgets for the
outsourcing of chemistry services, which are an important source of revenue for us. We believe that in the medium to longer term, however, companies such as ours may be well positioned to play an
important role in filling the gap in the pipeline of new drugs, either on their own or as partners of pharmaceutical companies. Our gene discovery programs are aimed at identifying novel drug targets
that are involved in the basic biology of common diseases and we are focused on discovering new drugs against these targets, both on our own and with major pharmaceutical partners. Our partnerships
with Roche and Merck demonstrate that the industry is already investing in the development of new therapeutics based on our approach. Similarly, it is possible that the pharmaceutical industry, in the
interest of reducing internal overhead, may opt to increase its outsourcing of contract chemistry services.

Collaborations and Alliances

Collaborations and further growth in our medicinal chemistry, pharmacogenomics and informatics services will remain an important element of our business strategy
and future revenues. Our ability to generate revenue growth and become profitable is dependent, in part, on our ability to enter into additional collaborative arrangements, and on our ability and our
collaborative partners' ability to

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successfully
commercialize products incorporating, or based on, our work. It is also dependent on our ability to maintain and grow our service lines of business. There can be no assurance that we will
be able to maintain or expand our existing collaborations, enter into future collaborations to develop applications based on existing or future research agreements, sign additional subscribers to our
database services, or successfully expand our medicinal chemistry or pharmacogenomics businesses. Our failure to successfully develop and market products over the next several years, or to realize
product revenues, would have a materially adverse effect on our business, financial condition and results of operations. We do not expect to receive royalties or other revenues from commercial sales
of products developed using our technologies in the near term. It may be several years before product revenues materialize, if they do at all.

We
have entered into research, development and commercialization alliances and collaborations with major pharmaceutical and biotechnology companies across our business model. These
alliances provide us with varied combinations of fixed funding for research, technology access fees, royalties and milestones. Our partners include Merck, Wyeth, Roche, Roche Diagnostics, Pharmacia
(now Pfizer) and Vertex. These agreements are generally established for a set term, usually three to five years.

Acquisitions

As part of our business strategy, we continue to consider joint development programs and merger and acquisition opportunities that may provide us with products in
late-stage development, intellectual property or financial resources, or with capabilities that will help accelerate our downstream drug discovery efforts.

On
March 18, 2002, we acquired MediChem Life Sciences, Inc. in a stock-for-stock exchange accounted for as a purchase transaction. The acquisition
gives us capabilities in chemistry and structural proteomics that will be used in the implementation of its strategy of turning its targets identified by applying population genomics to common
diseases into novel drugs for the market. Building upon the acquisition of MediChem (now our pharmaceutical and biostructures groups), we will be creating an integrated biopharmaceutical company
capable of bringing our own targets into proprietary drug discovery. Through the acquisition we added approximately 160 new employees and facilities in Illinois and Washington.

Our
consolidated financial statements include the cash flows and results of MediChem from March 18, 2002. The following unaudited pro forma financial information presents our
consolidated results as if the acquisition of MediChem occurred at the beginning of 2002. Nonrecurring charges, such as the acquired in-process research and development charge of $480,000
are not reflected in the following pro forma financial information. This pro forma information is not intended to be indicative of future operating results.

For the Six-Months
Ended June 30,Actual
2003

Pro-forma
2002(in thousands, except per share amounts)Total Revenues

$
22,378

$
18,788Net loss


(23,274
)

(39,713
)Basic and diluted net loss per share


(0.45
)

(0.78
)


With
MediChem, our revenues have increased as have our operating expenses. We expect to fund the working capital needs and operating activities of MediChem in the near term. The extent
to which MediChem will ultimately impact our results of operations and financial condition in the longer term is largely dependant upon what proportion MediChem's capacity is brought to bear on our
in-house programs and how much of their existing contract services business is maintained and developed.

16

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Critical Accounting Policies

The preparation of financial statements in conformity with generally accepted accounting principles requires us to make certain estimates and assumptions that
affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses
during the reported period. On an ongoing basis we evaluate our estimates, which include, among others, those related to collaborative arrangements, long-lived assets, materials and
supplies, foreign exchange transactions, income taxes and litigation and other contingencies. We base our estimates on historical experience and on various other assumptions that we believe to be
reasonable under the circumstances, the results of which form our basis for making judgments about carrying values of assets and liabilities that are not readily apparent from other sources. The
impact and any associated risks related to these and our other accounting policies on our business or operations is discussed throughout Management's Discussion and Analysis of Financial Condition and
Results of Operations where such policies affect our reported and expected financial results. For a detailed discussion on the application of these and other accounting policies, please refer to our
notes to the Consolidated Financial Statements in the Annual Report on Form 10-K. There can be no assurance that actual results may not differ from the estimates referred to above.

Results of Operations for the Three and Six Month Periods Ended June 30, 2003 and 2002

Our results of operations have fluctuated from period to period and may continue to fluctuate in the future based upon, among other things, the timing and
composition of funding under our various collaborative agreements, as well as the progress of our own research and development efforts. Results of operations for any period may be unrelated to results
of operations for any other period. In addition, historical results should not be viewed as indicative of future operating results. We are subject to risks common to companies in our industry and at
our stage of development, including risks inherent in our research and development efforts, reliance upon collaborative partners, development by us or our competitors of new technological innovations,
ability to market products or services, dependence on key personnel, dependence on key suppliers, protection of proprietary technology, ability to obtain additional financing, ability to negotiate
collaborative arrangements, reliance on the license to create and run the Icelandic Health Sector Database, and compliance with governmental and other regulations. In order for a product to be
commercialized based on our research, we and our collaborators must conduct preclinical tests and clinical trials, demonstrate the efficacy and safety of our product candidates, obtain regulatory
approvals or clearances and enter into manufacturing, distribution and marketing arrangements, as well as obtain market acceptance. We do not expect to receive revenues or royalties based on
therapeutic or diagnostic products for a period of years, if at all.

Revenues.Our revenues from research and development collaboration agreements are recorded and recognized in accordance with
the applicable performance requirements and terms of the respective contracts, generally either (i) as contract research costs are incurred, usually ratably over the period of effort,
(ii) according to the percentage of completion method of contract accounting based on the ratio of costs incurred to expected total costs, or (iii) upon the achievement of substantive
milestones, that is where the milestone event is substantive, there is substantial effort involved in achieving the milestone, the milestone payment amount is commensurate with the magnitude of the
related achievement, and the associated follow-on revenue streams bear a reasonable relationship to one another. Milestone payments without these characteristics are recognized on a
retrospective basis over the contractual term of the underlying agreement. Funding payments are not refundable in the event that the related efforts are not successful. Non-refundable,
up-front payments are deferred and recognized on a straight-line basis over the contract term. Contracted chemistry services revenue from negotiated rate contracts are
recognized on a per diem basis as services are rendered or on the percentage of completion method based on the ratio of costs incurred to expected total costs for fixed

17

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fee
contracts based upon the terms of the underlying contract. Any losses on contracts are provided for when they are determinable. Included in revenue are billings to customers for the cost of
materials purchased by deCODE.

In
general, prerequisites for billings are established by contractual terms including predetermined payment schedules, the achievement of contract milestones, or submission of
appropriate billing detail. Revenue recorded represents amounts billed in accordance with contractual terms. Unbilled costs and fees arise when revenue has been recognized but customers have not been
billed. Contractual payments
due to deCODE are recorded as deferred revenue until earned. The following is a summary of deferred revenue:

|                                                                    |  | For the Three Months
Ended June 30, |         | For the Six Months
Ended June 30, |  
|------------------------------------------------------------------- |  | ----------------------------------- | ------- | --------------------------------- | -
|
|
|Revenue recorded during the period                                  |  | $                                   | 10,466  |                                   | $
|Revenue recognized during the period                                |  |                                     | (10,536 | )                                 |  
|Deferred revenue recorded on acquisition of MediChem                |  |                                     | 0       |                                   |  
|Cumulative effect of change in milestone revenue recognition policy |  |                                     | 0       |                                   |  
|                                                                    |  |                                     |         |                                   |  
|                                                                    |  |                                     | (70     | )                                 |  
|Deferred revenue at beginning of period                             |  |                                     | 12,759  |                                   |  
|                                                                    |  |                                     |         |                                   |  
|Deferred revenue at end of period                                   |  | $                                   | 12,689  |                                   | $
|                                                                    |  |                                     |         |                                   |  

Our
revenue was down 11% from the first quarter 2003 to $10.5 million for the three-month period ended June 30, 2003 which compares to $9.4 million for the
three-month period ended June 30, 2002, an increase of 12%. Our revenue increased to $22.4 million for the six month period ended June 30, 2003 as compared to $14.7 million
for the six month period ending June 30, 2002, an increase of 52%. These revenues reflect performance across our business, including revenue from new partnerships we have formed and the
contributions of our pharmaceuticals and biostructures groups, as well as research and product development milestones. Revenue recognized in the three and six month period ended June 30, 2003
results largely from our diagnostics and therapeutics collaborations with Roche, from funding in our alliance with Merck and from the contribution of our pharmaceuticals and biostructures groups. The
increase in revenue in the three and six month period ended June 30, 2003 as compared to the same period in 2002 largely is attributable the contribution of our pharmaceuticals and
biostructures groups and to the addition of funding in our alliance with Merck. Roche accounted for 39% and 40% of consolidated revenue in three-month periods ended June 30, 2003 and 2002,
respectively, and 42% and 55% of consolidated revenue in six-month periods ended June 30, 2003 and 2002, respectively, and Merck accounted for 18% and 16% of consolidated revenue in
the three and six month periods ended June 30, 2003, repectively.

At
June 30, 2003, the total amount of deferred revenue that will be recognized in future periods aggregated $12.7 million. Revenue recorded was essentially the same from
the first quarter 2003 to $10.5 million for the three month period ended June 30, 2003 as compared to $15.8 million for the three month period ended June 30, 2002, a 34%
decrease. Revenues recorded were essentially the same at $20.9 million for the six month period ended June 30, 2003 and $21.0 million for the six month period ended
June 30, 2002. Revenue recorded in the 2003 periods as compared to revenue recorded in the 2002 periods is largely attributable to the contribution of our pharmaceuticals and biostructures
groups and to our collaboration with Merck, offset somewhat by access fees recorded in 2002 in connection with our diagnostics collaboration with Roche.

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Research and Development Expenses, including Cost of Revenue.Our research and development expenses were down 15% from the
first quarter 2003 to $16.8 million for the three-months ended June 30, 2003, which compares to $24.0 million for the three-months ended June 30, 2002, a decrease of 30%.
Our research and development expenses decreased to $36.6 million for the six-month period ended June 30, 2003 as compared to $42.9 million for the
six-month period ended June 30, 2002, a decrease of 15%. Our research and development expenses for the three and six month periods ended June 30, 2003 reflect spending
related to the range of our disease-gene research programs, including product development and downstream work on targets already identified as well as our pharmaceutical and biostructures
groups, which are now an integral part of our operations. Our research and development expenses for the three and six month periods ended June 30, 2003 mark the beginnings of the impact of the
cost reduction measures we implemented late in 2002, taking advantage of investments in automation in our disease-gene research programs and with notable reductions in salary expense, usage of
chemicals and consumables and research and development overheads.

Selling, General and Administrative Expenses.Our selling, general and administrative expenses were down 9% from the first
quarter 2003 to $3.7 million for the three-month period ended June 30, 2003, which compares to $5.1 million for the three-month period ended June 30, 2002, a decrease of
27%. Our selling, general and administrative expenses decreased to $7.8 million for the six-month period ended June 30, 2003 as compared to $8.4 million for the six
month period ended June 30, 2002, a decrease of 7%. Our selling, general and administrative expenses for three and six month periods ended June 30, 2003 reflect expanded sales efforts
across our businesses and the costs of our pharmaceutical and biostructures groups, but also mark the beginnings of the impact of the cost reduction measures we implemented late in 2002.

Employee Termination Benefits.In September of 2002, we implemented a cost reduction program including charges related to
termination benefits for 132 employees. Of the $2.2 million then provided, $1.3 million was paid in 2002 and $0.9 million remained accrued and unpaid as of December 31,
2002. Charges for termination benefits for 27 additional employees were added ($0.5 million) and total termination benefits of $1.2 million were paid in the three-months ended
March 31, 2003, leaving $0.2 million accrued and unpaid as of March 31, 2003. Charges for termination benefits for 17 additional employees were added ($0.3 million) and
total termination benefits of $0.2 million were paid in the three-months ended June 30, 2003 leaving $0.3 million accrued and unpaid as of June 30, 2003. Termination
benefits remaining accrued and unpaid as of June 30, 2003 (17 employees) are expected to be settled in cash over the next six months.

Stock-Based Compensation and Remuneration.Stock-based compensation and remuneration expense was $0.5 million for the
three-month period ended June 30, 2003 as compared to $0.9 million for the three-month period ended June 30, 2002, a decrease of 36%. Stock-based compensation and remuneration
expense was $1.1 million for the six-month period ended June 30, 2003 as compared to $1.8 million for the six-month period ended June 30, 2002, a
decrease of 38%. With little compensation being attributed to our more recent stock option grants, stock-based compensation and remuneration expense has been decreasing as grants made to employees in
earlier years become fully vested or forfeited. Historical stock-based compensation and remuneration is not necessarily representative of the effects on reported income or loss for future years due
to, among other things, the vesting period of the stock options, the value of stock options that have been granted in recent times and the value of additional options that may be granted in future
years.

Interest Income.Our interest income decreased to $0.3 million for the three-month period ended June 30, 2003
as compared to $0.7 million for the three-month period ended June 30, 2002, a decrease of 57%. Our interest income decreased to $0.7 million for the six-month period
ended June 30, 2003 as compared to $1.6 million for the six-month period ended June 30, 2002, a decrease of 58%. The

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decrease
is attributable to the decline of prevailing interest rates but also from an overall decrease in our cash balance as we continue to use the proceeds of our initial public offering for
operations.

Interest Expense.Our interest expense decreased to $0.9 million expense for the three-month period ended
June 30, 2003 as compared to $1.3 million for the three-month period ended June 30, 2002, a decrease of 36%. Our interest expense increased to $1.8 million for the
six-month period ended June 30, 2003 as compared to $1.6 million for the six-month period ended June 30, 2002, an increase of 10%. Our interest expense
reflects the cost of financings put into place during the late part of 2001 and early part of 2002. The decrease for the three month period ended June 30, 2003 as compared to the three month
period ended June 30, 2002 is largely attributable to a decline in underlying Libor rates.

Other non-operating income and (expense), net.Our other non-operating income and expense, net was a
net income of $0.6 and $0.7 million for the three and six month periods ended June 30, 2003, respectively and a net income of $0.6 and $0.7 million for the three and six month
periods ended June 30, 2002. Our other non-operating income and expense, net for the three and six month periods ended June 30, 2003 comprises unrealized swap gains
($1.0 million and $1.2 million, respectively) and net foreign exchange losses ($0.4 million and $0.5 million, respectively).

Income Taxes.As of June 30, 2003, we had an accumulated deficit of $318.4 million and did not owe any
Icelandic or U.S. federal income taxes nor did we pay any in the three and six month periods ended June 30, 2003 or 2002. As of December 31, 2002, we had net operating losses able to be
carried forward for U.S. federal income tax purposes of approximately $32.2 million to offset future taxable income in the United States that expire at various dates through 2022. Also, as of
December 31, 2002 our foreign subsidiaries had net operating loss carryforwards of approximately $107.4 million that expire in varying amounts beginning in 2006.

Net Loss and Basic and Diluted Net Loss Per Share.Net loss and basic and diluted net loss per share were
$10.2 million and $0.20 per share, respectively, for the three-month period ended June 30, 2003, as compared to $19.7 million and $0.39 per share, respectively, for the
three-month period ended June 30, 2002, a decrease of 48% in net loss and a decrease of 49% in basic and diluted net loss per share. Net loss and basic and diluted net loss per share were
$23.3 million and $0.45 per share, respectively, for the six-month period ended June 30, 2003, as compared to $35.6 million and $0.75 per share, respectively, for the
six-month period ended June 30, 2002, a decrease of 35% in net loss and a decrease of 40% in basic and diluted net loss per share. Increased revenue and the introduction of
significant operational efficiencies account for these reductions.

Liquidity and Capital Resources

We have financed our operations primarily through funding from collaborative agreements and the issuance of equity securities and debt instruments
($467 million from the beginning of 1999 to-date). As of June 30, 2003, future funding under terms of our existing agreements is approximately $64 million excluding
milestone payments and royalties that we may earn under such collaborations.

Cash and Cash Equivalents.As of June 30, 2003, we had $76.6 million in cash and cash equivalents, including
$6 million of restricted cash. Available cash is invested in accordance with our investment policy's primary objectives of liquidity, safety of principal and diversity of investments. Our cash
is deposited only with financial institutions in Iceland, the United Kingdom and the United States having a high credit standing. This cash is largely invested in U.S. dollar denominated money market
and checking accounts and also in Icelandic krona denominated accounts.

Operating Activities.Working capital needs resulted in the net use of $2.9 million of funds in the
six-month period ended June 30, 2003 and $0.9 million in the six-month period ended June 30, 2002. Net cash used in operating activities decreased
$10.0 million in the six-month period ended June 30,

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2003
as compared to the six-month period ended June 30, 2002, reflecting the beginnings of the impact of the cost reduction measures we implemented late in 2002.

Investing Activities.Our investing activities have consisted of capital expenditures and long-term strategic
equity investments in, and acquisitions of, technologies and businesses that are complementary to our business. Purchases of property and equipment during the six-month period ended
June 30, 2003 were $0.5 million as compared to $13.2 million in the six-month period ended June 30, 2002. We principally made replacement capital expenditures
during the six-month period ended June 30, 2003. During the six-month period ended June 30, 2002 we expended $5.7 million in respect of the new building,
$2.8 million for the purchase of DNA analyzers under our supply agreement with ABG and acquired $3.3 million of cash in the purchase of MediChem. There were also $4.0 million of
MediChem transaction costs, resulting in a net outlay of cash for the six month period ended June 30, 2002 in connection with the acquisition of $0.7 million. Net cash used in investing
activities may in the future fluctuate significantly from period to period due to the timing of our capital expenditures and other investments.

Financing Activities.Net cash of $1.8 million was provided by financing activities in the six-month
period ended June 30, 2003 as compared to $4.3 million in the six-month period ended June 30, 2002. Financing activities for the six-month period ended
June 30, 2003 largely consisted of the sale and 18-month leaseback of certain laboratory equipment ($4.8 million) and installment payments on our existing debt and capital
lease obligations ($3.1 million). In December 2001, we established a $27.5 million bridge loan with an Icelandic financial institution to finance the construction of our new
headquarters facility. We repaid the borrowings under the bridge loan in January and March 2002 with the proceeds from our Tier A $13.5 million bond offering, Tier C $7.3 million
offering of privately placed bonds and Tier D $6.7 million bank loan. $14 million of cash that was restricted as of December 31, 2001 was provided in 2002 in the final financing
(Tiers C and D) of our new headquarters facility.

We
seek to maintain a desired level of floating-rate debt with respect to our overall debt portfolio denominated in U.S. dollars. To this end, we have entered into two
interest rate and cross-currency swaps to manage interest rate and foreign currency risk arising from long-term debt obligations denominated in Icelandic krona. These interest rate and
cross-currency swaps with a remaining combined notional amount of 1,930 million Icelandic krona are designated as economic hedges of fixed rate foreign currency debt (Tier A and Tier C bonds),
but do not qualify for hedge accounting under SFAS 133. The estimated fair value of these instruments is included in other long-term assets is $9.2 million and
$5.3 million as of June 30, 2003 and 2002, respectively. The unrealized gain for the six-month periods ended June 30, 2003 and 2002 resulting from the recording of
these instruments together with the translation of the Tier A and Tier C bonds is $1.2 million and $1.3 million, respectively, and is included in other non-operating income
and (expense), net in the Consolidated Statements of Operations.

GeneralFollowing the implementation in September 2002 of a plan to reduce headcount and maximize the use of
automation in our core genetics operations and based upon current plans, we believe that our existing resources will be adequate to satisfy our capital needs for several years. Our cash requirements
depend on numerous factors, including our ability to obtain new research collaboration agreements, to obtain subscription and collaboration agreements for the database services; to obtain and maintain
contract service agreements in our chemistry services and clinical research trials groups; expenditures in connection with alliances, license agreements and acquisitions of and investments in
complementary technologies and businesses; competing technological and market developments; the cost of filing, prosecuting, defending and enforcing patent claims and other intellectual property
rights; the purchase of additional capital equipment, including capital equipment necessary to ensure that our sequencing and genotyping operations remain competitive; and capital

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expenditures
required to expand our facilities. Changes in our research and development plans, the entry into clinical trials of a drug based on our discoveries, or other changes affecting our
operating expenses may result in changes in the timing and amount of expenditures of our capital resources.

We
will require significant additional capital in the future, which we may seek to raise through further public or private equity offerings, additional debt financing or added
collaborations and licensing arrangements. No assurance can be given that additional financing or collaborations and licensing arrangements will be available when needed, or that if available, will be
obtained on favorable terms. If adequate funds are not available when needed, we may have to curtail operations or attempt to raise funds on unattractive terms.

Recent Accounting Pronouncements

In January 2003, the FASB issued FASB Interpretation No. 46 ("FIN 46"), "Consolidation of Variable Interest Entities, an Interpretation of ARB
No. 51." FIN 46 requires certain variable interest entities to be consolidated by the primary beneficiary of the entity if the equity investors in the entity do not have
the characteristics of a controlling financial interest or do not have sufficient equity at risk for the entity to finance its activities without additional subordinated financial support from other
parties. FIN 46 is effective for all new variable interest entities created or acquired after January 31, 2003. For variable interest entities created or acquired prior to February 1,
2003, the provisions of FIN 46 must be applied for the first interim or annual period beginning after June 15, 2003. We adopted this standard on July 1, 2003 and its adoption did not
have a material impact on our financial position or results of operations.

In
November 2002, the Emerging Issues Task Force reached a consensus on Issue No. 00-21 ("EITF 00-21"), "Revenue Arrangements with Multiple
Deliverables." EITF 00-21 provides guidance on how to account for arrangements that involve the delivery or performance of multiple products, services and/or rights to use assets. The
provisions of EITF 00-21 will apply to revenue arrangements entered into in fiscal periods beginning after June 15, 2003. We are evaluating the potential impact of EITF
00-21 on our financial position and results of operations.

In
April 2003, the Financial Accounting Standards Board (FASB) released Statement of Financial Accounting Standards (SFAS) No. 149, "Amendment of Statement 133 on Derivative
Instruments and Hedging Activities." SFAS No. 149 clarifies under what circumstances a contract with an initial net investment meets the characteristics of a derivative, amends the definition
of an underlying contract, and clarifies when a derivative contains a financing component in order to increase the comparability of accounting practices under SFAS No. 133. The statement is
effective for contracts entered into or modified after June 30, 2003, and for hedging relationships designated after June 30, 2003. The adoption of SFAS No. 149 is not expected to
have a material impact on our financial position or results of operations.

In
May 2003, the FASB issued SFAS No. 150, "Accounting for Certain Financial Instruments with Characteristics of both Liabilities and Equity." This Statement establishes
standards for how an issuer classifies and measures certain financial instruments with characteristics of both liabilities and equity. It requires that an issuer classify a financial instrument that
is within its scope as a liability (or an asset in some circumstances). Many of those instruments were previously classified as equity. The Statement is effective for financial instruments entered
into or modified after May 31, 2003. We adopted this standard on June 1, 2003 and its adoption did not have any impact on our financial position or results of operations.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

The primary objective of our investment activities is to preserve principal while maximizing income we receive from our investments without significantly
increasing risk. Some of the securities in our

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investment
portfolio may be subject to market risk. This means that a change in prevailing interest rates may cause the market value of the investment to fluctuate. For example, if we hold a security
that was issued with a fixed interest rate at the then-prevailing rate and the prevailing interest rate later rises, the market value of our investment will probably decline. To minimize
this risk in the future, we intend to maintain our portfolio of cash equivalents and short-term investments in a variety of securities, including commercial paper, money market funds and
government and non-government debt securities. In general, money market funds are not subject to market risk because the interest paid on such funds fluctuates with the prevailing interest
rate. As of June 30, 2003, all of our cash and cash equivalents were in money market and checking accounts.

We
are exposed to market risks from changes in foreign currency exchange rates, interest rates and investment prices. These changes may adversely affect our operating results and
financial condition. We seek to manage these risks through regular operating and financing activities and, when deemed appropriate, through the use of derivative financial instruments. We control and
manage foreign exchange risk, interest rate risk, and investment price risk by continually monitoring changes in key economic indicators and market information.

As
a consequence of the nature our business and operations our reported financial results and cash flows are exposed to the risks associated with fluctuations in the exchange rates of
the U.S. dollar, the Icelandic krona and other world currencies. We continue to monitor our exposure to currency risk but have not yet purchased instruments to hedge these general risks through the
use of derivative financial instruments.

We
hold various interest rate sensitive assets and liabilities to manage the liquidity and cash needs of our day-to-day operations. As a result, we are exposed to
risks due to changes in interest rates. In order to mitigate risks associated with interest rate sensitive liabilities we use interest rate derivative instruments, such as cross currency interest rate
swaps, and may in future use other instruments to achieve the desired interest rate maturities and asset/liability structures.

We
are exposed to credit (or repayment) risk, as well as market risk from the use of derivative instruments. If the counterparty fails to fulfill its performance obligations under a
derivative contract, our credit risk will equal the positive market value in a derivative. Consequently, when the fair market value of a derivative contract is positive, this indicates that the
counterparty owes us, thus creating a
repayment risk for us. When the fair market value of a derivative contract is negative, we owe the counterparty and therefore, assume no repayment risk.

In
order to minimize the credit risk in derivative instruments, we enter into transactions with high quality counterparties such as financial institutions that satisfy our established
credit approval criteria. We review the credit ratings of such counterparties on a regular basis.

Item 4. Controls and Procedures

a) Evaluation of disclosure controls and procedures. Our Chief Executive Officer and our Chief Financial Officer evaluated the effectiveness of deCODE's
disclosure controls and procedures (as defined in Rule 13a-15(e) under the Securities Exchange Act of 1934, as amended (the "Exchange Act")) as of the end of the fiscal quarter
covered by this Quarterly Report on Form 10-Q. Based upon that evaluation, the Chief Executive Officer and the Chief Financial Officer have concluded that, except as described
below, as of the end of such fiscal quarter deCODE's current disclosure controls and procedures are adequate and effective to ensure that information required to be disclosed in the reports deCODE
files under the Exchange Act is recorded, processed, summarized and reported on a timely basis.

We
are in the process of implementing the changes to our disclosure controls and procedures described in our Annual Report on Form 10-K for the year ended
December 31, 2002. These changes

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relate
to (1) notice provisions in, and waivers and amendments of, our contracts, (2) identification of, and communication by, non-executive personnel of deCODE of any
material information that they may receive and (3) our financial closing procedures.

b)
Changes in internal control over financial reporting. There was no change in deCODE's internal control over financial reporting (as defined in Rule 13a-15(f) under
the Exchange Act) during the fiscal quarter covered by this Quarterly Report on Form 10-Q that has materially affected, or is reasonably likely to materially affect, deCODE's
internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

There has been no change in the matters reported in our annual report on Form 10-K for the year ended December 31, 2002 except as
follows:

On
or about April 20, 2002, an amended class action complaint, captioned In re deCODE genetics, Inc. Initial Public Offering Securities Litigation (01 Civ. 11219(SAS)),
alleging violations of federal securities laws was filed in the United States District Court for the Southern District of New York on behalf of certain purchasers of deCODE common stock. The complaint
names us, two of our current executive officers (the "Individual Defendants"), and the two lead underwriters (the "Underwriter Defendants") for our initial public offering in July 2000 (the
"IPO") as defendants.

In
the amended pleading, the plaintiff alleges violations of Section 11 of the Securities Act of 1933 and violations of Section 10(b) of the Securities Exchange Act of 1934
(and Rule 10b-5 promulgated thereunder) against us, the Individual Defendants and the Underwriter Defendants. In addition, the amended complaint alleges violations of
Section 15 of the Securities Act of 1933, and Section 20(a) of the Securities Exchange Act of 1934 against the Individual Defendants. Generally, the amended complaint alleges that the
Underwriter Defendants: (i) solicited and received excessive and undisclosed commissions from certain investors in exchange for which the Underwriter Defendants allocated to those investors
material portions of the shares of our stock sold in the IPO; (ii) entered into agreements with customers whereby the Underwriter Defendants agreed to allocate shares of our stock sold in the
IPO to those customers in exchange for which the customers agreed to purchase additional shares of our stock in the aftermarket at pre-determined prices; and (iii) improperly used
their analysts, who purportedly suffered from conflicts of interest, to manipulate the market. The amended complaint further alleges that the prospectus incorporated into the registration statement
for the IPO was materially false and misleading in that it failed to disclose these arrangements. The amended complaint also alleges that we and the Individual Defendants had numerous interactions and
contacts with the Underwriters from which we and the Individual Defendants either knew of, or recklessly disregarded, the Underwriters' purported wrongful acts. The suit seeks unspecified monetary and
recissionary damages and certification of a plaintiff class consisting of all persons who purchased shares of our common stock from July 17, 2000 to December 6, 2000.

We
are aware that similar allegations have been made in hundreds of other lawsuits filed (many by some of the same plaintiff law firms) against numerous underwriter defendants and issuer
companies (and certain of their current and former officers) in connection with various public offerings conducted in recent years. All of the lawsuits that have been filed in the Southern District of
New York have been consolidated for pretrial purposes before Honorable Judge Shira Scheindlin. Pursuant to the underwriting agreement executed in connection with our IPO, we have demanded
indemnification from the Underwriter Defendants. The Underwriter Defendants have asserted that our request for indemnification is premature.

Pursuant
to an agreement the Individual Defendants have been dismissed from the case without prejudice. Along with numerous other issuers, we moved to dismiss the complaint for failure
to state a claim. On February 19, 2003, Judge Scheindlin granted our motion with respect to the Section 10(b) claims and denied the motion with respect to the Section 11 claims.

On
July 31, 2003, our Board of Directors (other than Dr. Stefansson) conditionally approved a proposed partial settlement with the plaintiffs in this matter. The settlement
would provide, among other things, a release of deCODE and of the Individual Defendants for the conduct alleged in the amended complaint to be wrongful. We would agree to undertake other
responsibilities under the partial settlement, including agreeing to assign away, and not assert or release, certain potential claims we may have against our underwriters. Any direct financial impact
of the proposed settlement is

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expected
to be borne by our insurers. The Board agreed to approve the settlement subject to a number of conditions, including the participation of a substantial number of other issuer defendants in
the proposed settlement, the consent of our insurers to the settlement, and the completion of acceptable final settlement documentation. Furthermore, the settlement is subject to a hearing on fairness
and approval by the Court overseeing the litigation.

Due
to the inherent uncertainties of litigation and the fact that the settlement is in its early stages, the ultimate outcome of this matter cannot be predicted. If the settlement is not
consummated, we expect to contest the allegations against us and our officers vigorously. If we were required to pay significant monetary damages as a result of such litigation (or any other lawsuits
alleging similar claims filed against us and our officers in the future), our business could be significantly harmed. Even if such suit concludes in our favor, we may be required to expend significant
funds to defend against the allegations. We are unable to estimate the range of possible loss from the litigation and no amounts have been provided for such matters in our financial statements.

Item 5. Other Information

Risk Factors, Forward-Looking Statements, and Cautionary Factors That May Affect Future Results

This report contains forward-looking statements. These statements relate to future events or our future financial performance. In some cases, forward-looking
statements can be identified by terminology such as "may," "will," "should," "could," "expect," "plan," "anticipate," "believe," "estimate," "predict," "intend," "potential" or "continue" or the
negative of such terms or other comparable terminology. These statements are only predictions. We cannot assure our investors that our expectations and assumptions will prove to have been correct. We
undertake no intention or obligation to update or revise any forward-looking statements, whether as a result of future events, new information or otherwise. Actual events or results may differ
materially due to a number of factors, including those set forth in this section and elsewhere in this Form 10-Q. These factors include, but are not limited to, the risks set forth
below.

Risks Related to Our Business

deCODE May Not Successfully Develop or Derive Revenues From Any Products or Services.

deCODE uses its technology and research capabilities primarily to identify genes or gene fragments that are responsible for certain diseases, indicate the
presence of certain diseases or cause or predispose individuals to certain complex diseases. Although deCODE has identified some genes that it believes are likely to cause certain diseases, deCODE may
not be correct and may not be successful in identifying any other similar genes. Many experts believe that some of the diseases deCODE is targeting are caused by both genetic and environmental
factors. Even if deCODE identifies specific genes that are partly responsible for causing diseases, any gene-based therapeutic or diagnostic products may not detect, prevent, treat or cure
a particular disease. Accordingly, even if deCODE is successful in identifying specific genes, its discoveries may not lead to the development of commercial therapeutic or diagnostic products.

Any
pharmaceutical or diagnostic products that deCODE or its collaborators are able to develop will fail to produce revenues unless deCODE:



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deCODE
may not be able to meet these conditions. deCODE expects that it will be years, if ever, before it will recognize revenue from the development of therapeutic or diagnostic
products.

deCODE's
Clinical Genome Miner contains tools to discover or validate disease linked genes based on non-personally identifiable genotypic, genealogical and phenotypic data.
deCODE cannot be sure that marketing the Clinical Genome Miner or the Clinical Genome Miner Discovery(TM) will lead to additional collaborations with potential clients.

The
success of deCODE's informatics services and tools depends on its ability to:



Because
only a small portion of the Icelandic population may carry certain mutations, the unwillingness of even a small portion of the population to participate in deCODE's programs
could diminish its ability to develop and market information based on the use of genotypic data. If deCODE fails to successfully commercialize its database services, it will not realize revenues from
this part of its business.

These
products may not meet the needs of potential customers. deCODE has generated little revenues from sales or licenses of informatics products. deCODE cannot assure you that it can
successfully develop or commercialize, or that there will be a market for, its informatics products.

If deCODE Continues to Incur Operating Losses Longer Than Anticipated, or in Amounts Greater Than Anticipated, It May Be Unable to Continue Its Operations.

deCODE incurred a net loss of $23.3 million for the six-month period ended June 30, 2003, and has an accumulated deficit of
$318.4 million at June 30, 2003. deCODE has never generated a profit and it has not generated revenues except for payments received in connection with its research and development
collaborations with Roche, Merck and other collaborations, and from contract services and interest income. Our research and development expenditures and general and administrative costs have exceeded
our revenue to date, and we expect to spend significant additional amounts to fund research and development in order to enhance our core technologies and undertake product development (including drug
development and related clinical trials). As a result, we expect that our operating expenses will increase significantly in the near term, and we will need to generate significant additional revenues
to achieve profitability. deCODE must also continue to make substantial expenditures over the next several years to develop its technologies and its internal research programs and to prepare the
Clinical Genome Miner(TM), the CGM Discovery(TM), the Iceland Health Sector Database and other informatics. Also, with MediChem, deCODE's revenues have increased but operating expenses and, at least
for the near term, likely net losses will also increase. In addition, deCODE expects to continue to fund the working capital needs and operating activities of MediChem in the near term. As a result,
deCODE expects to incur net losses for several years. If the time required to generate product revenues and achieve profitability is longer than deCODE currently anticipates or the level of losses is
greater than deCODE currently anticipates, deCODE may not be able to continue its operations.

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If deCODE's Assumption About the Role of Genes in Disease Is Wrong, It May Not Be Able to Develop Useful Products.

The products deCODE hopes to develop involve new and unproven approaches. They are based on the assumption that information about genes may help scientists to
better understand complex disease processes. Scientists generally have a limited understanding of the role of genes in diseases, and few products based on gene discoveries have been developed. Of the
products that exist, all are diagnostic products. To date, deCODE knows of no therapeutic products based on disease-gene discoveries. If deCODE's assumption about the role of genes in the
disease process is wrong, its gene discovery programs may not result in products, the genetic data included in its database and informatics products may not be useful to its customers and those
products may lose any competitive advantage.

Because Revenues Are Concentrated, the Loss of a Significant Customer Would Harm deCODE's Business.

Historically, a substantial portion of deCODE's revenue has been derived from contracts with a limited number of significant customers. deCODE's largest customer,
Roche, accounted for approximately 41% of its consolidated revenue in 2002 and 42% of consolidated revenue in the six-month period ended June 30, 2003. Revenue under deCODE's
alliance with Merck accounted for approximately 4% of consolidated revenue in 2002 and 16% of consolidated revenue in the six-month period ended June 30, 2003. Revenues under the
joint development and commercialization agreement with ABG, which was terminated in the fourth quarter of 2002, accounted for 15% of consolidated revenue in the year ended December 31, 2002.
The loss of any significant customer may significantly lower deCODE's revenues and affect deCODE's progression to profitability.

If deCODE Is Not Able to Obtain Sufficient Additional Funding to Meet Its Capital Requirements, deCODE May Be Forced To Reduce or Terminate Its Research Programs and Product
Development.

deCODE has spent substantial amounts of cash to fund its research and development activities and expects to continue to spend substantial amounts for these
activities over the next several years. deCODE expects to use cash to collect, generate and analyze genotypic and disease data from volunteers in its disease-gene research programs; to
conduct drug discovery and development activities; to continue to develop the Clinical Genome Miner and Clinical Genome Miner Discovery; to develop healthcare informatics products; and to continue
other research and development activities. Many factors will influence its future capital needs, including:



deCODE
intends to rely on Roche, Merck and other existing and future collaborators for significant funding of its research efforts. In addition, deCODE may seek additional funding
through public or private equity offerings and debt financings. deCODE may not be able to obtain additional financing when it needs it or the financing may not be on terms favorable to deCODE or its
stockholders. Stockholders' ownership will be diluted if deCODE raises additional capital by issuing equity securities.

If
deCODE raises additional funds through collaborations and licensing arrangements, it may have to relinquish rights to some of its technologies or product candidates, or grant licenses
on unfavorable

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terms.
If adequate funds are not available, deCODE would have to scale back or terminate its discovery and research programs and product development.

The
Icelandic parliament has enacted legislation authorizing the Minister of Finance to provide an Icelandic government guarantee of a convertible bond offering of up to
$200 million by deCODE for the purpose of financing new activities of deCODE in the area of drug development. To become effective, this legislation must be approved by the EFTA (i.e. the
European Free Trade Association) Surveillance Authority (ESA) for compatibility with the state aid stipulations of the agreement on the European Economic Area (EEA), to which Iceland is a signatory.
The measure is still under review by ESA, which announced on July 16, 2003 that it would conduct a formal investigation procedure with regard to the proposed state guarantee. deCODE cannot be
certain that ESA will approve the legislation, that the Icelandic government will make use of the authorization and offer the guarantee to deCODE for any or all of the permitted amount, that such
offer to deCODE by the Icelandic Government, if effectuated, will be on terms acceptable to deCODE, or that even with such an authorization deCODE will be able to find a market for such an offering of
convertible bonds.

deCODE's Current Facilities and Staff Are Inadequate For Commercial Production and Distribution of Products.

If in the future deCODE chooses to engage directly in the development, manufacturing and marketing of certain products, it will require substantial additional
funds, personnel and production facilities.

deCODE's Reliance on the Icelandic Population May Limit the Applicability Of Its Discoveries to Certain Populations.

The genetic make-up and prevalence of disease generally varies across populations around the world. Common complex diseases generally occur with a
similar frequency in Iceland and other European populations. However, the populations of other nations may be genetically predisposed to certain diseases because of mutations not present in the
Icelandic population. As a result, deCODE and its partners may be unable to develop diagnostic and therapeutic products that are effective on all or a portion of people with such diseases. Any
difference between the Icelandic population and other populations may have an effect on the usefulness of the Clinical Genome Miner and Icelandic Health Sector Database in studying populations outside
of Iceland. For deCODE's business to succeed, it must be able to apply discoveries that it makes on the basis of the Icelandic population to other markets.

If deCODE Fails to Protect Confidential Data Adequately, It Could Incur a Liability or Lose Its Database License.

Under laws and regulations in force in Iceland, including applicable European laws, directives and regulations, all information on individuals that is used in
deCODE's population research is anonymized under the protocols and supervision of the Data Protection Authority of Iceland. To extent that any of this data held or generated by the company were to
become personally identifiable deCODE would risk losing public support for participation in its research, and could be liable to legal action. Any failure to comply fully with all confidentiality
requirements could lead to liability for damages incurred by individuals whose privacy is violated, the loss of its customers and reputation and the loss of the goodwill and cooperation of the
Icelandic population, including healthcare professionals. These eventualities could materially adversely affect deCODE's work in Iceland.

The
same general privacy and data protection laws and regulations as well as specific laws and regulations apply to deCODE's license to build and operate the Icelandic Health Sector
Database (IHD). Were any data sent to or contained in the IHD to become personally identifiable, deCODE would incur the same risks above and potentially lose its database license.

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deCODE's Creation and Operation of the Icelandic Health Sector Database May Be More Expensive and Time Consuming Than deCODE Anticipates, and May Lead to Litigation.

deCODE's development of the Icelandic Health Sector Database (IHD) involves substantial government regulation and oversight, compliance with which can be
expensive and time-consuming and may delay, prevent or increase the cost of development of the IHD.
Data collection and use activities will be supervised by the Icelandic Health Sector Database Monitoring Committee, the Data Protection Authority of Iceland, and an Interdisciplinary Ethics Committee.
In addition, the Icelandic Bioethics Committee will review deCODE's operation of the database.

Iceland
is subject to both European Free Trade Association and European Union competition and public procurement rules. If it is determined that the Database Act or the Database License
breaches such rules, the Database License could be revoked or diluted. In addition to the costs of developing the system, the terms of the license require us to pay the Icelandic government a fixed
fee for operating the IHD of 70 million Icelandic Krona per year (approximately $914,000 USD as of June 2003), and an additional 6% of any profits per annum from its commercialization.

Even
if deCODE is able to successfully create and market the Icelandic Health Sector Database, the Database License will expire in January 2012. There is no assurance that deCODE
will obtain further access rights on favorable terms, if at all.

The
Icelandic parliament's passage of the Database Act and the Health Ministry's granting of the Database License have encountered some opposition in Iceland and internationally.
Opponents of the IHD may initiate litigation in U.S., Icelandic or other national or international courts (for example, on the basis of an alleged breach of the patient-doctor confidentiality,
constitutional privacy issues, international conventions dealing with protection of privacy issues or human rights conventions). In February 2000, certain Icelandic opponents of the IHD issued
a press release announcing their intention to file lawsuits against the State of Iceland and any other relevant parties, including deCODE, to test the constitutionality of the Database Act. According
to the press release, the lawsuit will allege human rights violations and challenge the validity of provisions of the Database Act. To date no such suit has been brought against deCODE. One lawsuit
has been brought in Icelandic courts against the Directorate of Public Health in Iceland challenging the constitutionality of the Database Act. In the event that the Icelandic State by a final
judgment is found to be liable or subject to payment to any third party as a result of the passage of legislation on the Icelandic Health Sector Database and/or the issuance of the Database License,
deCODE's agreement with the Health Ministry requires deCODE to indemnify the Icelandic State against all damages and costs incurred in connection with such litigation. In addition, the pendency of
such litigation could lead to delay in the development of the Icelandic Health Sector Database and an unfavorable outcome could prevent deCODE from developing and operating the Icelandic Health Sector
Database.

Some Parts of deCODE's Product Development Services Create a Risk of Liability from Clinical Trial Participants and the Parties With Whom It Contracts.

deCODE, through its wholly-owned subsidiary Encode ehf., contracts with drug companies to perform a wide range of services to assist them in bringing new drugs to
market. deCODE also contracts with physicians to serve as investigators in conducting clinical trials. deCODE's services include:



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If,
in the course of these trials or activities deCODE does not perform its services to contractual or regulatory standards;



deCODE
could then be held be held liable for these eventualities by the drug companies with whom it contracts or by study participants. deCODE maintains insurance to cover ordinary
risks, but such insurance may be inadequate and it would not cover the risk of a customer deciding not to do business with deCODE as a result of poor performance.

Use of Therapeutic or Diagnostic Products Developed as a Result of deCODE's Programs May Result in Product Liability Claims for Which deCODE Has Inadequate Insurance.

The users of any therapeutic or diagnostic products developed as a result of deCODE's discovery or research programs or the use of its database or medical
decision-support products may bring product liability claims against deCODE. deCODE currently does not carry liability insurance to cover such claims. deCODE is not certain that it or its
collaborators will be able to obtain such insurance or, if obtained, that sufficient coverage can be acquired at a reasonable cost. If deCODE cannot protect against potential liability claims,
deCODE's collaborators or deCODE may find it difficult or impossible to commercialize products.

deCODE May Be Unable to Hire and Retain the Key Personnel Upon Whom Its Success Depends.

deCODE depends on the principal members of its management and scientific staff, including Dr. Kari Stefansson, Chairman, President and Chief Executive
Officer, Hannes Smarason, Executive Vice President and Senior Business Officer, and Dr. Jeffrey Gulcher, Vice President, Research and Development. deCODE genetics, Inc. has not entered
into agreements with any of the named persons that bind them to a specific period of employment. If any of these people leaves deCODE, deCODE's ability to conduct its operations may be negatively
affected. deCODE's future success also will depend in part on its ability to attract, hire and retain additional personnel. There is intense competition for such qualified personnel and deCODE cannot
be certain that it will be able to continue to attract and retain such personnel. Failure to attract and retain key personnel could have a material adverse effect on deCODE.

Currency Fluctuations May Negatively Affect deCODE's Financial Condition.

deCODE publishes its consolidated financial statements in U.S. dollars. Currency fluctuations can affect its financial results because a portion of its cash
reserves and its operating costs are in Icelandic kronas. A fluctuation of the exchange rates of the Icelandic krona against the U.S. dollar can thus adversely affect the "buying power" of deCODE's
cash reserves and revenues. Most of deCODE's long-term liabilities are U.S. dollar denominated. However, deCODE may enter into hedging transactions if it has substantial foreign currency
exposure in the future. deCODE may have increased exposure as a result of investments or payments from collaborative partners.

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deCODE's Contracts May Terminate Upon Short Notice.

Many of deCODE's contracts are terminable on short notice. This means that deCODE's contracts could be terminated for numerous reasons, any of which may be beyond
its control such as a reduction or reallocation of a customer's research and development budget or a change in a customer's overall financial condition. The loss of a large contract or multiple
smaller contracts, or a significant decrease in revenue derived from a contract, could significantly reduce deCODE's profitability and require it to reallocate under-utilized physical and professional
resources.

Risks Related to Our Collaborators

deCODE May Not Be Able to Form and Maintain the Collaborative Relationships That Its Business Strategy Requires and the Relationships May Lead to Disputes Over Technology
Rights.

Our ability to generate revenue growth and become profitable is dependent, in part, upon our ability to enter into additional collaborative arrangements, and upon
our ability and that of our collaborative partners to successfully commercialize products incorporating, or based upon, our work.

deCODE
must form research collaborations and licensing arrangements with several partners at the same time in order to execute its business strategy. deCODE currently has only six
substantial collaborative relationships, including two with Roche. To succeed, deCODE will have to maintain or
expand these relationships and establish additional collaborations. There can be no assurance that we will be able to maintain or expand our existing collaborations, enter into future collaborations
to develop applications based on existing or future research agreements, sign additional subscribers to our database services, or successfully expand our medicinal chemistry or pharmacogenetics
businesses. Our failure to successfully develop and market products over the next several years, or to realize product revenues, would have a material, adverse effect on our business, financial
condition and results of operations. We do not expect to receive royalties or other revenues from commercial sales of products developed using our technologies in the near term. It may be several
years before product revenues materialize, if they do at all.

If
deCODE's collaborations are not successful or deCODE is not able to manage multiple collaborations successfully, its programs will suffer. If deCODE increases the number of
collaborations, it will become more difficult to manage the various collaborations successfully and the potential for conflicts among the collaborators as to rights and products generated under work
conducted with deCODE will increase.

Dependence on Collaborative Relationships May Lead to Delays in Product Development and Disputes Over Rights to Technology.

deCODE is dependent on collaborators for the pre-clinical study and clinical development of therapeutic and diagnostic products and for regulatory
approval, manufacturing and marketing of any products that result from its technology. deCODE's agreements with collaborators typically allow them significant discretion in electing whether to pursue
such activities. deCODE cannot control the amount and timing of resources collaborators will devote to its programs or potential products.

Agreements with Collaborators May Have the Effect of Limiting the Areas of Research That deCODE May Pursue Either Alone or with Others.

deCODE's arrangements may place responsibility for key aspects of information technology, product development and marketing on its collaborative partners. If
deCODE's collaborators fail to perform their obligations, deCODE's information technology products could contain erroneous data, design defects, viruses or software defects that are difficult to
detect and correct and may adversely

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affect
its revenues and the market acceptance of its products. deCODE's collaborators may stop supporting its products or providing services to it if they develop or obtain rights to competing
products. Disputes may arise in the future over the ownership of rights to any technology developed with collaborators. These and other possible disagreements between deCODE's collaborators and deCODE
could lead to delays in the collaborative research, development or commercialization of products. Such disagreements could also result in litigation or require arbitration to resolve.

Risks Related to Our Industry

Concerns Regarding the Use of Genetic Testing Results May Limit the Commercial Viability of Any Products deCODE Develops.

Other companies have developed genetic predisposition tests that have raised ethical concerns. It is possible that employers or others could discriminate against
people who have a genetic predisposition to certain diseases. Concern regarding possible discrimination may result in governmental authorities enacting restrictions or bans on the use of all, or
certain types of, genetic testing. Similarly, such concerns may lead individuals to refuse to use genetic tests even if permissible. These factors may limit the market for, and therefore the
commercial viability of, products that deCODE's collaborators and/or deCODE may develop.

deCODE May Not Be Able to Compete Successfully with Other Companies and Government Agencies in the Development and Marketing of Product Services.

A number of companies are attempting to rapidly identify and patent genes that cause diseases or an increased susceptibility to diseases. Competition in this
field and deCODE's other areas of business, including drug discovery and development as well as database services and healthcare informatics, is intense and is expected to increase. deCODE has
numerous competitors, including major pharmaceutical and diagnostic companies, specialized biotechnology firms, universities and other research institutions, the United States-funded Human Genome
Project and other government-sponsored entities and companies providing healthcare information products. deCODE's collaborators, including Roche and Merck, may also compete with deCODE. Many of
deCODE's competitors, either alone or with collaborators, have considerably greater capital resources, research and development staffs and facilities, and technical and other resources than deCODE
does, which may allow them to discover important genes before deCODE does. deCODE believes that a number of its competitors are developing competing products and services that may be commercially
successful and that are further advanced in development than its potential products and services. To succeed, deCODE, together with its collaborators, must discover disease-predisposing genes,
characterize their functions, develop genetic tests or therapeutic products and related information services based on such discoveries, obtain regulatory and other approvals, and launch such services
or products before competitors. Even if deCODE's collaborators or deCODE is successful in developing effective products or services, deCODE's products and services may not successfully compete with
those of its competitors. deCODE's competitors may succeed in developing and marketing products and services that are more effective than deCODE's or that are marketed before deCODE's.

Competitors
have established, and in the future may establish, patent positions with respect to gene sequences related to deCODE's research projects. Such patent positions or the public
availability of gene sequences comprising substantial portions of the human genome could decrease the potential value of deCODE's research projects and make it more difficult for deCODE to compete.
deCODE may also face competition from other entities in gaining access to DNA samples used for research and development purposes. Our competitors may also obtain patent protection or other
intellectual property rights that could limit our rights, or our customers' ability, to use our technologies or databases, or commercialize therapeutic or diagnostics products. In addition, we face,
and will continue to face, intense competition from other companies for collaborative arrangements with pharmaceutical

33

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and
biotechnology companies, for establishing relationships with academic and research institutions and for licenses to proprietary technology.

deCODE
expects competition to intensify as technical advances are made and become more widely known. deCODE's future success will depend in large part on maintaining a competitive
position in the genomics field. Others' or deCODE's rapid technological development may result in products or technologies becoming obsolete before deCODE recovers the expenses it incurs in developing
them.

Our
ability to compete successfully will depend, in part, on our ability, and that of our collaborators, to: develop proprietary products; develop and maintain products that reach the
market first, and are technologically superior to and more cost effective than other products on the market; obtain patent or other proprietary protection for our products and technologies; attract
and retain scientific and product development personnel; obtain required regulatory approvals; and manufacture, market and sell products that we develop.

Changes in Outsourcing Trends and Economic Conditions in the Pharmaceutical and Biotechnology Industries Could Adversely Affect deCODE's Growth.

Economic factors and industry trends that affect deCODE's primary customers, pharmaceutical and biotechnology companies, also affect deCODE's business. For
example, the practice of many companies in these industries has been to outsource to organizations like deCODE to conduct genetic research, clinical research, sales and marketing projects and
chemistry research and development projects. If these industries reduce their present tendency to outsource those projects, deCODE's operations, financial condition and growth rate could be materially
and adversely affected. These alliances and arrangements are both time consuming and complex and we face substantial competition in establishing these relationships. In addition, our ability to
generate new business could be impaired by general economic downturns in our customers' industries.

Regulatory Approvals for Products Resulting from deCODE's Gene Discovery Programs Must Be Obtained or deCODE Will Not Be Able to Derive Revenues from These Products.

Government agencies must approve new drugs and diagnostic products in the countries in which they are to be marketed. deCODE cannot be certain that it can obtain
regulatory approval for any drugs or diagnostic products resulting from its gene discovery programs. The regulatory process can take many years and require substantial resources. Because some of the
products likely to result from deCODE's disease research programs involve the application of new technologies and may be based upon a new therapeutic approach, various government regulatory
authorities may subject such products to substantial additional review. As a result, these authorities may grant regulatory approvals for these products more slowly than for products using more
conventional technologies. Furthermore, regulatory approval may impose limitations on the use of a drug or diagnostic product.

After
initial regulatory approval, a marketed product and its manufacturer must undergo continuing review. Discovery of previously unknown problems with a product may have adverse
effects on deCODE's business, financial condition and results of operations, including withdrawal of the product from the market.

Our
success will depend, in part, on the development and marketing of products based upon our research and development. Strict regulatory controls on the clinical testing, manufacture,
labeling, supply and marketing of the products will influence our and our partners' ability to successfully manufacture and market therapeutic or diagnostic products. Most countries require a company
to obtain and maintain regulatory approval for a product from the relevant regulatory authority to enable the product to be marketed. Obtaining regulatory approval and complying with appropriate
statutes and regulations is time-consuming and requires the expenditure of substantial resources.

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Most
European countries and the United States have very high standards of technical appraisal and consequently, in most cases, a lengthy approval process for pharmaceutical products. The
regulatory approval processes, which usually include pre-clinical and clinical studies, as well as post-marketing surveillance to establish a compound's safety and efficacy,
can take many years and require the expenditure of substantial resources. Data obtained from such studies is susceptible to varying interpretations that could delay, limit or prevent regulatory
approval. Delays or rejections may also be encountered based upon changes in drug approval policies in applicable jurisdictions. There can be no assurance that we or our collaborative customers will
obtain regulatory approval for any drugs or diagnostic products developed as the result of our gene discovery programs.

Efforts to Reduce Healthcare Costs May Reduce Market Acceptance of deCODE's Products.

deCODE's success will depend in part on the price and extent to which it will be paid for its products by government and health administration authorities,
private health insurers and other third party payors. Reimbursement for newly approved healthcare products is uncertain. Third party payors, including Medicare in the United States, are increasingly
challenging the prices charged for medical products and services. They are increasingly attempting to contain healthcare costs by limiting both coverage and the level of reimbursement for new
therapeutic products. deCODE cannot be certain that any third party insurance coverage will be available to patients for any products deCODE discovers or develops. If third party payors do not provide
adequate coverage and reimbursement levels for deCODE's products, the market acceptance of these products may be materially reduced.

Numerous
governments have undertaken efforts to control growing healthcare costs through legislation, regulation and voluntary agreements with medical care providers and pharmaceutical
companies. If cost containment efforts limit the profits that can be derived from new drugs, deCODE's customers may reduce their research and development spending which could reduce the business they
outsource to deCODE.

Risks Related to Our Intellectual Property

deCODE May Not Be Able to Protect the Proprietary Rights That Are Critical to Its Success.

deCODE's success will depend in part on its ability to protect its genealogy database and genotypic data and any other proprietary databases that it develops and
its proprietary software and other proprietary methods and technologies. Despite deCODE's efforts to protect its proprietary rights, unauthorized parties may be able to obtain and use information that
deCODE regards as proprietary. deCODE's commercial success will depend in part on obtaining patent protection. The patent positions of pharmaceutical, biopharmaceutical and biotechnology companies,
including deCODE's, are generally uncertain and involve complex legal and factual considerations. deCODE cannot be sure that any of its pending patent applications will result in issued patents, that
it will develop additional proprietary technologies that are patentable, that any patents issued to deCODE or deCODE's partners will provide a basis for commercially viable products, will provide
deCODE with any competitive advantages or will not be challenged by third parties, or that the patents of others will not have an adverse effect on deCODE's ability to do business. If deCODE is unable
to obtain patent protection for its technology or discoveries, the value of its proprietary resources will be adversely affected.

In
addition, patent law relating to the scope of claims in the area of genetics and gene discovery is still evolving. There is substantial uncertainty regarding the patentability of
genes or gene fragments without known functions. The laws of some European countries provide that genes and gene fragments may not be patented. The Commission of the EU has passed a directive that
prevents the patenting of genes in their natural state. The U.S. Patent and Trademark Office initially rejected a patent application by the National Institutes of Health on partial genes. Accordingly,
the degree of future protection for deCODE's proprietary rights is uncertain and, deCODE cannot predict the breadth of

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claims
allowed in any patents issued to it to others. deCODE could also incur substantial costs in litigation if it is required to defend itself in patent suits brought by third parties or if it
initiates such suits.

Others
may have filed and in the future are likely to file patent applications covering genes or gene products that are similar or identical to deCODE's products. deCODE cannot be
certain that its patent applications will have priority over any patent applications of others. The mere issuance of a patent does not guarantee that it is valid or enforceable; thus even if deCODE is
holding or is granted patents it cannot be sure that they would be valid and enforceable against third parties. Further, a patent does not provide the patent holder with freedom to operate in a way
that infringes the patent rights of others. Any legal action against deCODE or its partners claiming damages and seeking to enjoin commercial activities relating to the affected products and processes
could, in addition to subjecting deCODE to potential liability for damages, require deCODE or its partners to obtain a license in order to continue to manufacture or market the affected products and
processes. There can be no assurance that its partners or deCODE would prevail in any action or that any license required under any patent would be made available on commercially acceptable terms, if
at all. If licenses are not available, its partners or deCODE may be required to cease marketing its products or practicing its methods.

If
expressed sequence tags, single nucleotide polymorphisms, or SNPs, or other sequence information become publicly available before deCODE applies for patent protection on a
corresponding full-length or partial gene, deCODE's ability to obtain patent protection for those genes or gene sequences could be adversely affected. In addition, other parties are
attempting to rapidly identify and characterize genes through the use of gene expression analysis and other technologies. If any patents are issued to other parties on these partial or
full-length genes or gene products or uses for such genes or gene products, the risk increases that the sale of deCODE's or its collaborators' potential products or processes may give rise
to claims of patent infringement. The amount of supportive data required for issuance of patents for human therapeutics is highly uncertain. If more data than deCODE has available is required, our
ability to obtain patent protection could be delayed or otherwise adversely affected. Even with supportive data, the ability to obtain patents is uncertain in view of evolving examination guidelines,
such as the utility and written description guidelines that the U.S. Patent and Trademark Office has adopted.

While
deCODE requires employees, academic collaborators and consultants to enter into confidentiality agreements, there can be no assurance that proprietary information will not be
disclosed, that others will not independently develop substantially equivalent proprietary information and
techniques, otherwise gain access to our trade secrets or disclose such technology, or that deCODE can meaningfully protect its trade secrets.

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Item 6. Exhibits and Reports on Form 8-K

(a)
Exhibits

The
following is a list of exhibits filed as part of this Quarterly Report on Form 10-Q.

|Exhibit
Number |  | Description of Exhibit                                                                                                                                                                                                                                    
|-------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|3.1            |  | Amended and Restated Certificate of Incorporation, as further amended (Incorporated by reference to Exhibit 3.1 and Exhibit 3.3 to the Company's Registration Statement on Form S-1 (Registration
No. 333-31984) which became effective on July 17, 2000).
|3.2            |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation dated August 30, 2002 (Incorporated by reference to Exhibit 3.2 to the Company's Quarterly Report on Form 10-Q filed on
November 14, 2002).                                 
|3.3            |  | Bylaws, as amended (Incorporated by reference to Exhibit 3.2 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on July 17, 2000).                                                                   
|4.1            |  | Specimen Common Stock Certificate (Incorporated by reference to Exhibit 4.1 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on July 17,
2000).                                                    
|4.2            |  | Form of Warrant to Purchase Series A Preferred Stock (Incorporated by reference to Exhibit 4.2 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on
July 17, 2000).                                 
|4.3            |  | Form of Warrant to Purchase Series C Preferred Stock (Incorporated by reference to Exhibit 4.3 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on
July 17, 2000).                                 
|4.4            |  | Warrant Certificate, dated May 6, 2002 issued to Islandsbanki-FBA hf. (Incorporated by reference to Exhibit 4.1 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                    
|4.5            |  | Form of Indexed Bond (Tier A) (Incorporated by reference to Exhibit 4.2 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                                                            
|4.6            |  | Form of Indexed Bond (Tier C) (Incorporated by reference to Exhibit 4.3 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                                                            
|31.1           |  | Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  
|31.2           |  | Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  
|32.1           |  | Certification pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  

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(b)
Reports on Form 8-K

On
April 1, 2003, deCODE filed a Current Report on Form 8-K reporting the issuance of a press release containing financial information regarding its results of
operations and financial condition for the years ended December 31, 2001 and December 31, 2002, and the quarters ended March 31, 2002, June 30, 2002 and
September 30, 2002.

On
May 14, 2003, deCODE filed a Current Report on Form 8-K reporting the issuance of a press release containing financial information regarding its results of
operations and financial condition for the quarter ended March 31, 2003.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned
thereunto duly authorized.

|Dated: August 13, 2003 | deCODE genetics, Inc.                                                                                                               
|---------------------- | ------------------------------------------------------------------------------------------------------------------------------------
|                       | /s/KARI STEFANSSONKari Stefansson
Chairman, President, and Chief Executive Officer                                                  
|                       | /s/LANCE THIBAULTLance Thibault
Chief Financial Officer and
Treasurer (principal financial
officer and principal accounting officer)

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|Exhibit
Number |  | Description of Exhibit                                                                                                                                                                                                                                    
|-------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|3.1            |  | Amended and Restated Certificate of Incorporation, as further amended (Incorporated by reference to Exhibit 3.1 and Exhibit 3.3 to the Company's Registration Statement on Form S-1 (Registration
No. 333-31984) which became effective on July 17, 2000).
|3.2            |  | Certificate of Amendment to Amended and Restated Certificate of Incorporation dated August 30, 2002 (Incorporated by reference to Exhibit 3.2 to the Company's Quarterly Report on Form 10-Q filed on
November 14, 2002).                                 
|3.3            |  | Bylaws, as amended (Incorporated by reference to Exhibit 3.2 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on July 17, 2000).                                                                   
|4.1            |  | Specimen Common Stock Certificate (Incorporated by reference to Exhibit 4.1 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on July 17,
2000).                                                    
|4.2            |  | Form of Warrant to Purchase Series A Preferred Stock (Incorporated by reference to Exhibit 4.2 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on
July 17, 2000).                                 
|4.3            |  | Form of Warrant to Purchase Series C Preferred Stock (Incorporated by reference to Exhibit 4.3 to the Company's Registration Statement on Form S-1 (Registration No. 333-31984) which became effective on
July 17, 2000).                                 
|4.4            |  | Warrant Certificate, dated May 6, 2002 issued to Islandsbanki-FBA hf. (Incorporated by reference to Exhibit 4.1 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                    
|4.5            |  | Form of Indexed Bond (Tier A) (Incorporated by reference to Exhibit 4.2 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                                                            
|4.6            |  | Form of Indexed Bond (Tier C) (Incorporated by reference to Exhibit 4.3 to the Company's Quarterly Report on Form 10-Q filed on May 15, 2002).                                                                                                            
|31.1           |  | Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  
|31.2           |  | Certification pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  
|32.1           |  | Certification pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                                                                                                                  

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