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                            Library & Multimedia
 Validating Multiplexes for Use in Conjunction With Modern Interpretation Strategies
NCJ Number
              250072
Journal

*Forensic Science International-Genetics* Volume: 20 Dated: January 2016 Pages: 6-19
Author(s)
          D. Taylor;
                        J. A. Bright
Date Published

January 2016
Length
              14 pages
Annotation
              This article presents a full scheme for validation of a new multiplex that is suitable for informing modern interpretation practice, predominantly using GlobalFiler as an example multiplex; however, it is suggested that the aspects investigated here are fundamental to introducing any multiplex in the modern interpretation environment.
Abstract
              In response to requests from the forensic community, commercial companies are generating larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now applied to a wider range of samples including complex multi-person mixtures. In parallel there is an overdue reappraisal of profile interpretation methodology. Aspects of this reappraisal include 1) the need for a quantitative understanding of allele and stutter peak heights and their variability; 2) an interest in reassessing the utility of smaller peaks below the often used analytical threshold; 3) a need to understand not just the occurrence of peak drop-in but also the height distribution of such peaks; and 4) a need to understand the limitations of the multiplex-interpretation strategy pair implemented. (Publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2011-DN-BX-K541


  
  
        
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        NIJ-Sponsored


  
  
        
  Award
        Population Genetic Issues for Forensic DNA Profiles
    
  
  
Date Published: January 1, 2016
    
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