AGEN-Exhibit 10.4.1 Q1 14








20th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 11/01/2010


BioCentiv [logo]




20th Addendum
to Lease Agreement No. 01/2003
from 12/01/2002


BioCentiv GmbH        (Lessor)
and             4-Antibody AG        (Lessee)


amend the above-mentioned Lease Agreement on the basis of the application of BioCentiv GmbH to the State Administration Office of Thuringia from 09/08/2010 (Annex 1 to this Addendum) and its approval from 10/05/2010 (Annex 2 to this Addendum) as follows:




Section 3 Term of lease, termination


The lease term is extended by three years until 02/28/2014.


The Lessee is granted the option of extending the lease for another two years. The Lessee must decide about exercising this option at least nine months before the expiry of the lease (05/31/2013).


A termination notice period of 12 months is agreed upon for the term of the lease.


The Lessor has the right to terminate the lease according to the contract, especially when other small and medium-sized companies express the need to use spaces in the BioInstrumentezentrum, and such need cannot be fulfilled otherwise. Such need must be demonstrated to the Lessee.




Section 4 Rent, other payments


The basis for the calculation of the rent starting from 03/01/2011 is the expert opinion of the Expert Office of Roland Fehler, Bad Langensalza, from 07/02/2008 (Annex 3 to this Agreement).


    














    









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20th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 11/01/2010


BioCentiv [logo]




Therefore, the following rent is payable starting March 2011:


	
				
	Subtotal rent, net
	

	€7,742.81
	


	Center’s flat charge
	

	€739.55
	


	Prepaid incidental expenses
	

	€4,000.00
	


	Total rent, net
	

	€12,482.36
	


	19% VAT
	

	€2,371.65
	


	Total rent, gross
	

	€14,854.01
	













Jena, 11/01/2010




	
			
	BioCentiv GmbH
	4-Antibody AG
Germany Branch



	[signature]
Dr. Klaus Ullrich
Director
	[signature]
Dr. Ulf Grawunder
Authorized Agent
	[signature]
Dr. Eva-Maria Stegemann
Authorized Agent

























































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Leased Properties in the Period (03/01/2011–02/28/2014)


Debtor/Lessee:        18 / 4-Antibody AG        Contract Type:    Standard Agreement
Contract No.:        01/2003
Contract Term:        03/01/2003–02/28/2014        Status:        active







	
															
	Leased Property
	Area
	Type of Use
	Price per m2
	Rent
	Flat Charge
	Prepaid Operating Costs

	 
	0.00 m2
	 
	

	€0.00
	

	

	€0.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space SP 06 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space SP 08 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space SP 09 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 03 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 04 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 10 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 13 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 37 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 41 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 47 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 48 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Open Space TG1 49 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	


	Room 1.201
	26.26 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€210.08
	

	

	€39.39
	

	

	€0.00
	


	Room 1.202
	26.57 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€212.56
	

	

	€39.86
	

	

	€2,000.00
	


	Room 1.203
	47.54 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€808.18
	

	

	€71.31
	

	

	€400.00
	


	Room 1.204
	49.35 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€838.95
	

	

	€74.03
	

	

	€600.00
	


	Room 1.205
	48.93 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€831.81
	

	

	€73.40
	

	

	€600.00
	


	Room 1.206
	49.70 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€844.90
	

	

	€74.55
	

	

	€0.00
	


	Room 1.207
	51.77 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€880.09
	

	

	€77.66
	

	

	€0.00
	


	Room 1.208
	42.66 m2
	3.3. Technological Lab
	

	€15.50
	

	

	€661.23
	

	

	€63.99
	

	

	€0.00
	


	Room 1.209
	6.31 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€31.55
	

	

	€9.47
	

	

	€0.00
	


	Room 2.301
	26.20 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€209.60
	

	

	€39.30
	

	

	€0.00
	


	Room 2.303
	49.07 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€834.19
	

	

	€73.61
	

	

	€400.00
	


	Room 2.305
	48.86 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€830.62
	

	

	€73.29
	

	

	€0.00
	


	Room 2.309
	6.31 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€31.55
	

	

	€9.47
	

	

	€0.00
	


	Room M1.014.4
	7.90 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€39.50
	

	

	€11.85
	

	

	€0.00
	


	Room M1.014.5
	5.60 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€28.00
	

	

	€8.40
	

	

	€0.00
	







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	Monday, 11/01/2010
	Innocad®
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