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                            Library & Multimedia
 Use of Nanoparticle Decorated Surface-Enhanced Raman Scattering Active Sol-Gel Substrates for SALDI-MS Analysis
NCJ Number
              307439
Journal

*Journal of the American Society for Mass Spectrometry* Volume: 34 Issue: 2 Dated: 2023 Pages: 273-278
Author(s)
          Andrew E. Paulson;
                        W. Ranjith Premasiri;
                        Lawrence D. Ziegler;
                        Young Jin Lee
Date Published

2023
Length
              6 pages
Annotation
              The authors of this paper adopt metal nanoparticle (NP) doped sol–gel substrates as surface-assisted laser desorption/ionization–mass spectrometry (SALDI-MS) substrates.
Abstract
              The authors adopt metal nanoparticle (NP) doped sol–gel substrates, initially developed for surface-enhanced Raman scattering (SERS) analysis, as surface-assisted laser desorption/ionization–mass spectrometry (SALDI-MS) substrates. Spectroscopy and mass spectrometry techniques are sometimes combined into the same analytical workflow to leverage each technique’s analytical benefits. This combined workflow is especially useful in forensic and medical contexts where samples are often precious in nature. Using dried blood and sample protocols previously developed for SERS analysis, the authors observe heme-related spectral features on both silver and gold NP substrates by SALDI-MS, demonstrating dual functionality for these orthogonal techniques. Modifying the dried blood extraction procedures also allows for the observation of blood triacylglycerols by SALDI-MS. This is the first demonstration of a SERS/SALDI-MS substrate based on a sol–gel scaffold and the first demonstration of a gold NP sol–gel substrate for SALDI-MS which features lower substrate-related SALDI-MS background compared to the silver substrate. (Published Abstract Provided)
      
  
          Additional Details
Grant Number(s)
        2018-MU-MU-0013


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Body fluid analysis detection and identification by surface enhanced Raman spectroscopy for forensic scientists
    
  
  
Date Published: January 1, 2023
    
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