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                            Library & Multimedia
 In Vitro Metabolism of Desomorphine
NCJ Number
              253445
Journal

*Forensic Science International* Volume: 289 Dated: August 2018 Pages: 140-149
Author(s)
          Jessica Winborn;
                        Donovan Haines;
                        Sarah Kerrigan
Date Published

August 2018
Length
              10 pages
Annotation
              The goal of this study was to contribute further knowledge regarding the metabolism of desomorphine, the principal pharmacologically active opioid in Krokodil, a homemade injectable drug that is perceived to be a cheaper alternative to heroin.
Abstract
              Recombinant human cytochrome P450 enzymes (rCYPs) and recombinant uridine 5ft-diphospho-glucuronosyltransferases (rUGTs) were used to investigate the biotransformational pathways involved. Samples were analyzed by liquid chromatography/quadrupole-time of flight-mass spectrometry (LC-Q/TOF-MS). Seven rCYP (rCYP2B6, rCYP2C8, rCYP2C9, rCYP2C18, rCYP2C19, rCYP2D6 and rCYP3A4) enzymes were found to contribute to desomorphine metabolism and eight phase I metabolites were identified, including nordesomorphine, desomorphine-N-oxide, norhydroxydesomorphine, and five hydroxylated species. Inhibition assays were used to confirm individual rCYP isoenzyme activity. Nine rUGTs (rUGT1A1, rUGT1A3, rUGT1A8, rUGT1A9, rUGT1A10, rUGT2B4, rUGT2B7, rUGT2B15, and rUGT2B17) were found to contribute to the formation of desomorphine-glucuronide. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2015-R2-CX-0031


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
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                                Program/Project Description


  
  
        
  Award
        Metabolism and Analysis of Desomorphine
    
  
  
Date Published: August 1, 2018
    
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