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                            Library & Multimedia
 Validation of LC–TOF-MS screening for drugs, metabolites, and collateral compounds in forensic toxicology specimens
NCJ Number
              306047
Journal

*Journal of Analytical Toxicology* Volume: 37 Issue: 1 Dated: January/February 2013 Pages: 17-24
Author(s)
          Fessessework Guale;
                        Shahriar Shahreza;
                        Jeffrey P. Walterscheid;
                        Hsin-Hung Chen;
                        Crystal Arndt;
                        Anna T. Kelly;
                        Ashraf Mozayani
Date Published

2012
Length
              8 pages
Annotation
              Since liquid chromatography time-of-flight mass spectrometry (LC–TOF-MS) analysis provides an expansive technique for identifying many known and unknown analytes, the current study developed a screening method that utilizes automated solid-phase extraction to purify a wide array of analytes involving stimulants, benzodiazepines, opiates, muscle relaxants, hypnotics, antihistamines, antidepressants and newer synthetic “Spice/K2” cannabinoids and cathinone “bath salt” designer drugs.
Abstract
              The extract was applied to LC–TOF-MS analysis, implementing a 13 min chromatography gradient with mobile phases of ammonium formate and methanol using positive mode electrospray. Several common drugs and metabolites can share the same mass and chemical formula among unrelated compounds, but they are structurally different. In this method, the LC–TOF-MS was able to resolve many isobaric compounds by accurate mass correlation within 15 ppm mass units and a narrow retention time interval of less than 10 s of separation. Drug recovery yields varied among spiked compounds, but resulted in overall robust area counts to deliver an average match score of 86 when compared to the retention time and mass of authentic standards. In summary, this method represents a rapid, enhanced screen for blood and urine specimens in postmortem, driving under the influence, and drug facilitated sexual assault forensic toxicology casework. (Published abstract provided)
      
  
          Additional Details
Grant Number(s)
        2010-DN-BX-K210


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Award
        FY2010 Forensic Technology Center of Excellence
    
  
  
Date Published: January 1, 2012
    
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      PatentsRelated Topics
        
                Driving Under the Influence (DUI)
        Forensic sciences
        Chromatography
        Synthetic cathinones
        Mass spectrometry



  
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