# Patent

## Title
Methods of making and methods of using antiseptic disinfectant, cosmetic and toiletries, medicine or food containing the same

## Abstract

The present invention relates to methods for producing and using antiseptic disinfectant, cosmetic and toiletries, medicine or food and method for antiseptically disinfecting a cosmetic and toiletries, medicine or food. The cosmetic and toiletries, medicine or food contain an antiseptic disinfectant comprising 1,2-alkanediol with 5-10 carbons and a fragrance component, and the fragrance component enhances the antibacterial activity that the 1,2-alkanediol originally has against a broad range of strains.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a divisional application of Ser. No. 10/500,358, filed Jun. 30, 2004, which was U.S. National Phase Application under 35 U.S.C. §371 of International Application No. PCT/JP03/12288, filed Sep. 25, 2003, which claimed the benefit of JP 2002-281678, filed Sep. 26, 2002, all contents of which are incorporated herein by reference.


TECHNICAL FIELD
The present invention relates to methods for producing and using antiseptic disinfectant, cosmetic and toiletries, medicine or food and method for antiseptically disinfecting a cosmetic and toiletries, medicine or food. The cosmetic and toiletries, medicine or food contain an antiseptic disinfectant comprising 1,2-alkanediol with 5-10 carbons and a fragrance component, and the fragrance component enhances the antibacterial activity that 1,2-alkanediol originally has against a broad range of strains.
TECHNICAL BACKGROUND
Paraben, benzoic acid, salicylic acid and so on have been used for the antiseptic disinfectants in the cosmetics and toiletries (including quasi drugs), medicine or food. As the above-mentioned conventional antiseptic disinfectants have low degree in their safety because of the high skin irritant etc., they have a defect that the range of the concentration for use tends to be limited. For example, the restricted concentration of paraben and benzoate for use is 1%, and the restricted concentration of benzoic acid and salicylic acid for use is 0.2%. Further, there have been problems that the antiseptic disinfection effect of those antiseptic disinfectants is not reliable because they are easily influenced by pH, and that antiseptic and antibacterial activity may remarkably fall by the combination use with other compounds such as surfactant. Still further, the number of people who are allergic to those antiseptic disinfectants is increasing in recent years. Therefore, more people are oriented to the safety, and so the demand for the cosmetics and toiletries, medicine and food without the antiseptic disinfectant or containing very reduced amount of it is increasing.
As the technical means to reduce or remove the antiseptic disinfectant, the antiseptic disinfectant containing 1,2-alkanediol (referring to publication No. 11-322591 of Published Japanese patent application) and moisturizing bacteriostatic for detergent or nondetergent cosmetics and toiletries containing 1,2-octanediol (referring to publication No. 2001-48720 of Published Japanese patent application) are disclosed. In using 1,2-alkanediol such as 1,2-octanediol solely for the antiseptic disinfectant, 1,2-alkanediol has to be compounded in a large amount if the nonionic surfactant exists in the compound. Further, as the 1,2-alkanediol has a peculiar odor of its material, it causes the problem of the odor when compounded in cosmetics and toiletries, etc.
Still further, for the technical means as to the antiseptic disinfectant using 1,2-alkanediol, a composition for external use compounded with 1,2-pentanediol and 2-phenoxyethanol (referring to publication No. 10-53510 of Published Japanese patent application) and an antiseptic disinfectant containing 1,2-alkanediol and paraben (referring to publication No. 11-310506 of Published Japanese patent application) are disclosed. The aims of those are, however, to improve the effect of antiseptic by the combination use of antiseptic and 1,2-alkanediol such as 1,2-pentanediol, but not to completely remove the antiseptic itself.
Meanwhile, fragrance compositions are generally compounded in the cosmetics and toiletries and food etc. to give rich smell to the products. It is known since a long time ago that the fragrance compositions theirselves have antibacterial action, and for example, the fragrance composition such as cresyl acetate, methyl eugenol, heliotropin and ethyl salicylate is disclosed as anticaries that has antibacterial action against mutans (referring to Published Japanese patent publication No. 5-67608). However, there has been a problem that the antibacterial action only by the fragrance composition does not give enough antiseptic disinfectant effect for cosmetics, toiletries and so on.
In view of the above-mentioned circumstances, the inventors, after studying very hard, found that combination use of 1,2-alkanediol and a specific fragrance composition enhances the antibacterial activity which 1,2-alkanediol originally has against many different kinds of strains to mask the odor of 1,2-alkanediol material, thereby the present invention has been completed.
DISCLOSURE OF THE INVENTION
The invention described in claim 1 relates to a method of using an antiseptic disinfectant, including the steps of combining 1,2-alkanediol with 5-10 carbons with one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene to form an antiseptic disinfectant; and adding the antiseptic disinfectant to a cosmetic and toiletries, medicine or food.
The invention described in claim 2 relates to the method of using an antiseptic disinfectant described in claim 1, wherein the 1,2-alkanediol is 1,2-hexanediol and/or 1,2-octanediol.
The invention described in claim 3 relates to the method of using an antiseptic disinfectant described in claim 1, wherein the 1,2-alkanediol is 1,2-octanediol.
The invention described in claim 4 relates to a method of using a cosmetic and toiletries, comprising the steps of providing an antiseptic disinfectant including 1,2-alkanediol with 5-10 carbons and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene; combining the antiseptic disinfectant with cosmetically effective agent to form a cosmetic and toiletries; and applying the cosmetic and toiletries to human or animal skin.
The invention described in claim 5 relates to the method of using a cosmetic and toiletries of claim 4, wherein the 1,2-alkanediol is 1,2-hexanediol and/or 1,2-octanediol.
The invention described in claim 6 relates to the method of using a cosmetic and toiletries of claim 4, wherein the 1,2-alkanediol is 1,2-octanediol.
The invention described in claim 7 relates to a method of using a medicine including the steps of providing an antiseptic disinfectant comprising 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of thymol eugenol, citronellal, terpinyl acetate, citronellol and β-pinene; combining the antiseptic disinfectant with a medicinally effective agent to form a medicine; and applying the medicine to human or animal skin or administering the medicine to human or animal.
The invention described in claim 8 relates to the method of using a medicine described in claim 7, wherein the 1,2-alkanediol is 1,2-hexanediol and/or 1,2-octanediol.
The invention described in claim 9 relates to the method of using a medicine described in claim 7, wherein the 1,2-alkanediol is 1,2-octanediol.
The invention described in claim 10 relates to a method of using a food including the steps of providing an antiseptic disinfectant comprising 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol, and β-pinene; combining the antiseptic disinfectant with a nutritionally effective edible substance to form a food; and feeding the food to human or animals.
The invention described in claim 11 relates to the method of using a food described in claim 10, wherein the 1,2-alkanediol is 1,2-hexanediol and/or 1,2-octanediol.
The invention described in claim 12 relates to the method of using a food described in claim 10, wherein the 1,2-alkanediol is 1,2-octanediol.
The invention described in claim 13 relates to a method of antiseptically disinfecting a cosmetic and toiletries, medicine or food, including the steps of providing an antiseptic disinfectant including a 1,2-alkanediol with 5-10 carbons and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol, and β-pinene, and combining the antiseptic disinfectant with one selected from the group consisting of a cosmetically effective agent, a medicinally effective agent and a nutritionally effective edible substance.
The invention described in claim 14 relates to the method of antiseptically disinfecting a cosmetic and toiletries, medicine or food described in claim 13, wherein the 1,2-alkanediol is 1,2-hexanediol and/or 1,2-octanediol.
The invention described in claim 15 relates to the method of antiseptically disinfecting a cosmetic and toiletries, medicine or food described in claim 13, wherein the 1,2-alkanediol is 1,2-octanediol.



BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 is a diagram showing an example of a method to determine the effect of compounding two antibacterial materials by means of dual minimum inhibitory concentration.
FIG. 2 is dual minimum inhibitory concentration diagrams as to thymol.
FIG. 3 is dual minimum inhibitory concentration diagrams as to eugenol.
FIG. 4 is dual minimum inhibitory concentration diagrams as to citronellal.
FIG. 5 is dual minimum inhibitory concentration diagrams as to terpinyl acetate.
FIG. 6 is dual minimum inhibitory concentration diagrams as to citronellol.
FIG. 7 is dual minimum inhibitory concentration diagrams as to β-pinene.
FIG. 8 is dual minimum inhibitory concentration diagrams as to isobornyl acetate.
FIG. 9 is dual minimum inhibitory concentration diagrams as to guajac acetate.



BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the antiseptic disinfectant of the present invention is disclosed in detail. The antiseptic disinfectant of the present invention contains 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene.
The first component of the antiseptic disinfectant of the present invention is 1,2-alkanediol with 5-10 carbons as indicated in the following chemical formula 1, and more specifically, it can be 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, or 1,2-decanediol.




(“n” in the formula represents integer 2-7).

In the present invention, one of the above-mentioned 1,2-alkanediols can be used solely, or two or more of those can be compounded.
1,2-alkanediol itself has a fine antibacterial activity, and takes effect of enhancing the antibacterial activity of the antiseptic disinfectant. Especially, in the present invention, it is preferable to use 1,2-hexanediol or 1,2-octanediol out of 1,2-alkanediols with 5-10 carbons as they have superior antibacterial activity against Eumycetes such as bacteria, yeast, Fungi and so on. It would be more preferable to use 1,2-octanediol.
The second component of the antiseptic disinfectant of the present invention is one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene.
The second component is the fragrance composition which not only masks the peculiar odor of 1,2-alkanediol but also enhances the antibacterial activity.
Thymol is achromatic crystal or crystalline which has a molecular formula of C10H12O, aromatic odor like thyme oil and acrid taste. Thymol also has a fine antiseptic and bactericidal activity. Thymol can be obtained by extracting from essential oil such as ajowan oil and the like, or by the reaction of m-cresol at the existence of isopropyl chloride and aluminum chloride under cooled condition.
Eugenol is light yellow-colored liquid which has a molecular formula of C10H12O2 and the aromatic odor like clove oil. Eugenol is included in essential oil such as clove oil, cassia oil, pimento oil, bay oil, camphor oil and so on. Eugenol can be obtained by extracting phenol from the essential oil by means of dilute alkaline solution and neutralizing it by means of mineral acid or carbons dioxide.
Citronellal is achromatic or light yellow-colored liquid which has a molecular formula of C10H18O and the aromatic odor like lemon. It is included in citronella oil, melissa oil and so on. It can be obtained by the process of fractional distillation of the essential oil, processing with acid sodium sulfite to prepare the crystalline addition compound, cleaning with flux to remove adulterants, decomposing it with alkali carbonsate, and refining after steam distillation and vacuum distillation.
Terpinyl acetate is achromatic liquid which has a molecular formula of C12H20O2 and the strong aromatic odor like bergamot and lavender. It can be obtained by heating pinene for many hours with excessive amount of acetic acid, or by boiling terpineol diluted by dimethylbenzene using a reflux condenser of acetic anhydride and sodium acetate.
Citronellol is achromatic liquid which has a molecular formula of C10H20O and the aromatic odor like roses. It is included in citronella oil, Geranium oil, rose oil and so on. It can be obtained by reduction of citronellal.
β-pinene is achromatic liquid which has a molecular formula of C10H16. It is important as a starting raw material for synthetic perfumes, and is included in terpentine oil.
In the present invention, one material from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene can be used solely, or two or more of those can be compounded.
In the antiseptic disinfectant of the present invention, the content of both of the first component 1,2-alkanediol with 5-10 carbons and the second component fragrance compositions are not limited, but it would be preferred that they are compounded to satisfy the weight ratio to be between 0.5:1 and 100:1, more preferably between 1:1 and 10:1. It is not preferable to compound 1,2-alkanediol over 100 times as much as fragrance components by weight because the effect of enhancing antibacterial activity cannot be expected in the condition, while it is not preferable to compound 1,2-alkanediol under 0.5 times as much by weight because the aromatic odor increases too much in the condition.
The antiseptic disinfectant includes 1,2-alkanediol as the first component, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene as the second component, it masks the raw material odor of 1,2-alkanediol. At the same time, fine antiseptic disinfectant activity against bacterias, yeast, fungi and so on can be shown because of the multiplier effect by the first and second components as indicated in the test mentioned below. Consequently, it is not necessary to compound the conventional antiseptic disinfectant such as paraben, benzoic acid and salicylic acid, thereby the high level of safety is secured.
The above-mentioned antiseptic disinfectant of the present invention can be used for the composition of cosmetics and toiletries, medicine, or food.
Specifically, it can be preferably used for skin cosmetics and toiletries such as facial cleansing, skin lotion, emulsion, cream, foundation, mascara, nail enamel and rouge, for hair cosmetics and toiletries such as shampoo, hair treatment, hair growth stimulant, hair cream, hair lotion, hair foam, permanent wave agent, for medicinal cosmetics (quasi drugs) for a definite purpose such as chloasma or ephelides, for medicine such as curative medicine for acne, collutorium or troches, and further for food such as chewing gums, candies or beverages.
In preparing cosmetics and toiletries, medicine or food with the antiseptic disinfectant of the present invention, the compositions which are usually contained in the cosmetics, toiletries, medicine or food can optionally be compounded within the amount that does not spoil the effect of the present invention. For example, fat, cere, higher fatty acid, lower alcohol, higher alcohol, sterol, fatty acid ester, humectant agent, surfactant, high molecular compound, inorganic pigment, coloring matter, fragrance composition, antioxidant, ultraviolet absorber, vitamin, astringent, skin whitening agent, extract from animals and plants, sequestering agent, purified water and so on would be enumerated for cosmetics, toiletries or medicine (including quasi drugs).
As to food, oil of animals and plants, polysaccharide, sweetener, food color, gum base and so on can be enumerated for example.
In preparing cosmetics, toiletries, medicine or food, the content of the antiseptic disinfectant is not limited, but the composition contains 0.01-20 percent by weight of the antiseptic disinfectant, and, more preferably, contains 0.05-5 percent by weight of it. If more than 20 percent by weight of the antiseptic disinfectant is contained, additional effect would not be expected. While, if contained under 0.01 percent by weight, it would not be preferable because the enough antibacterial effect cannot be obtained.
EMBODIMENT
Embodiment 1
Candida albicans IFO1594 (mycotic stomatitis), Staphylococcus aureus IF013276 (Staphylococcus aureus), and Pseudomonas aeruginosa IF013275 (Pseudomonas) are used as sample bacterias.
(Preparation of Inoculating Bacteria)
For preparing bacteria, as to Staphylococcus aureus and Pseudomonas, they are incubated at 35° C. in the agar medium, and further incubated at 35° C. after transferred into the bouillon medium. The inoculating bacteria is prepared by diluting the obtained culture solution to about 108 inoculating cell/ml.
As to yeast (Candida albicans), the inoculating bacteria is prepared by incubating the yeast in the same way as Staphylococcus aureus and Pseudomonas at 30° C. and diluting the yeast to about 107 cell/ml.
(Preparation of Diluting Series of the Test Material)
With a dilution solvent of ethyl cellosolve of 20 w/w %, 1,2-octanediol solution of 5, 4, 3, 2.5, 2.25, 2, 1.75, 1.5, 1.25 and 1 w/v % are prepared.
While, as to thymol and the 50:50 by weight mixture of 1,2-octanediol and thymol, the dilution series are prepared by doubling diluting the 20w/v % solution.
(Measurement of Minimum Inhibitory Concentration (MIC))
1 ml of each of the above-mentioned dilution series including the test material and 9 ml of the agar medium are introduced to each schales, and the above-mentioned inoculating bacteria was applied on each of the schales at the length of 1 cm.
Staphylococcus aureus and Pseudomonas were incubated at 35° C., and it was judged whether or not the bacteria had grown two days later. The yeast was incubated at 25° C., and it was judged whether or not the bacteria had grown three days later. The minimum concentration in which the bacteria did not grow is MIC.
Still more, antibacterial activity can be evaluated by the MIC. When the concentration of the test material is low, it does not effect the microbes. As the concentration gets higher, growth inhibition occurs. Further, as the concentration gets higher, the growth inhibition progresses, eventually to stop growth. The concentration at the point is shown as MIC. Accordingly, when the concentration goes above MIC, microbes die.
(Evaluation of Dual Minimum Inhibitory Concentration)
Each MIC of the obtained 1,2-octanediol, thymol, and the 50:50 mixture by weight of 1,2-octanediol and thymol corresponding the compounding amount of 1,2-octanediol and thymol is plotted to make out the dual minimum inhibitory concentration. Action and effect in case that two kinds of antibacterial materials are compounded can be judged by the dual minimum inhibitory concentration. More specifically, the actions caused by compounding two antibacterial materials are roughly classified into synergistic action, additive action and counteraction. Synergistic action is the action in that two kinds of agent act synergistically, to enhance the antibacterial activity that the agents originally have. The additive action is the action in that the antibacterial activities of the agents are put together. The counteraction is the action in that one agent cancels the antibacterial activity of the other agent.
The method using dual minimum inhibitory concentration, as shown in FIG. 1 for example, is the method to measure MICs as to material A and Material B at different proportions of them and to judge the result in view of the graph. In this method, a line is drawn to connect MIC (point A) in using only material A to MIC (point B) in using only material B. When the MIC (point C) in using both materials is inside the line, it is judged to be Synergistic action that antibacterial activity was strengthened by the combined use. When the MIC (point D) is on the line, it can be judged to be the additive action. When the MIC (point E) is in the outside of the line, it is judged to be the counteraction that cancels antibacterial activity of one or both of the materials to decrease the antibacterial activity.
The dual minimum inhibitory concentration diagram as to the thymol is shown in FIG. 2.
(Evaluation of the Antibacterial Effect)
The antibacterial effect in the case of mixing 1,2-octanediol and thymol was evaluated by the following evaluation criterion from dual minimum inhibitory concentration diagram in FIG. 2. The result is described in the table 1.
<Evaluation Criterion>
◯: There is synergistic action in the antibacterial effect.
Δ: There is additive action in the antibacterial effect.
×: There is counteraction in the antibacterial effect.
Embodiment 2
Manipulating each of eugenol, isobornyl acetate and guaiac acetate in the same way as in Embodiment 1, each dual minimum inhibitory concentration of FIG. 3, FIG. 8 and FIG. 9 was obtained. From the obtained result, the antibacterial effect was evaluated by the above-mentioned evaluation criterion. The result is shown in the table 1.












TABLE 1







fragrance






component
C. albicans
S. aureus
P. aeruginosa




















Embodiment 1
Thymol
∘
∘
∘


Embodiment 2
Eugenol
∘
∘
∘


Comparative
isobornyl
x
∘
x


example 1
acetate


Comparative
guaiac
x
∘
x


example 2
acetate









Embodiment 3-4
Manipulating each of citronellal and terpinyl acetate for fragrance component the same way as in Embodiment 1 using Candida albicans IF01594 and Staphylococcus aureus IF013276, each dual minimum inhibitory concentration of FIGS. 4-5 was obtained. From the obtained result, the antibacterial effect was evaluated by the above-mentioned evaluation criterion. The result is shown in the table 2.











TABLE 2







fragrance





component
C. albicans
S. aureus





















Embodiment 3
citronellal
∘
∘



Embodiment 4
terpinyl
∘
∘




acetate



Comparative
isobornyl
x
∘



example 1
acetate



Comparative
guaiac
x
∘



example 2
acetate










Embodiment 5-6
Manipulating each of citronellol and β-pinene for fragrance component in the same way as in Embodiment 1 using Escherichia coli IFO3972 instead of Pseudomonas aeruginosa IF013275, each dual minimum inhibitory concentration of FIGS. 6-7 was obtained. Each dual minimum inhibitory concentration of isobornyl acetate and guaiac acetate against Escherichia coli was obtained in the same way. From the obtained result, the antibacterial effect was evaluated by the above-mentioned evaluation criterion. The result is shown in the table 3.












TABLE 3







fragrance






component
C. albicans
S. aureus
E. coli




















Embodiment 1
citronellol
∘
∘
∘


Embodiment 2
β-pinene
∘
∘
Δ


Comparative
isobornyl
x
∘
x


example 1
acetate


Comparative
guaiac
x
∘
x


example 2
acetate









From the result shown in the Table 1-3, it can be known that it enhances the antibacterial activity which 1,2-alkanediol originally has against a broad range of strains to use 1,2-alkanediol in combination with a certain fragrance component such as thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene.
On the other hand, it can be known that using 1,2-alkanediol in combination with other fragrance component such as isobornyl acetate or guaiac acetate does not enhance the antibacterial activity against a broad range of strains.
Examples of the compound of antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same according to the present invention are described as follows.
FORMULATION EXAMPLE 1
Humidity Retention Cream
















deca glyceryl monolaurate
1.0



POE (15) glyceryl monostearate
1.0



soybean phosphatide for hydrogenation
1.0



stearic acid
4.0



cetanol
2.0



behenyl alcohol
2.0



paraffin
3.0



squalane
12.0



jojoba oil
4.0



methyl polysiloxane
0.2



1,3-butylene glycol
3.0



L-arginine
0.1



xanthan gum
0.001



1,2-octanediol
0.25



eugenol
0.1



purified water
proper quantity



total
100 percent by weight










FORMULATION EXAMPLE 2
Hydrophilic Ointment
















ascorbic acid
0.5



polyoxyethylene cetyl ether
2.0



soybean phosphatide for hydrogenation
1.0



stearic acid
4.0



glyceric monostearate
10.0



liquid paraffin
10.0



Vaseline
4.0



cetanol
5.0



propylene glycol
5.0



1,2-hexanediol
0.5



citronellal
0.2



purified water
proper quantity



total
100 percent by weight










FORMULATION EXAMPLE 3
Beverage
















dextrose syrup
33.0



grapefruit juice
64.0



1,2-pentanedio
0.5



citronellol
0.01



fragrance
0.5



acidulant
proper quantity



total
100 percent by weight










Effect of the Invention
As disclosed above, the antiseptic disinfectant of the present invention enhances the antibacterial activity that 1,2-alkanediol originally have against a broad range of the strains. Accordingly, it is not necessary to compound the conventional antiseptic disinfectant, and high degree of safety can be obtained.
Further, when 1,2-hexanediol or 1,2-octanediol is used for 1,2-alkanediol, the antiseptic disinfectant with higher antibacterial activity can be obtained.
The cosmetics and toiletries, medicine or food of the present invention do not need to contain the conventional antiseptic disinfectant such as salicylic acid, benzoic acid or paraben, and the antiseptic disinfectant of the present invention has a excellent antibacterial activity. Accordingly, the compounding rate of the antiseptic disinfectant itself can be low, and the safety is extremely high.
INDUSTRIAL APPLICABILITY
The antiseptic disinfectant of the present invention enhances the antibacterial activity that 1,2-alkanediol originally have against a broad range of the strains, and has high degree of safety. Therefore, it can be suitably used as the antiseptic disinfectant for cosmetics and toiletries, medicine or food.

## Claims

1. A method of using an antiseptic disinfectant, comprising the steps of:
combining 1,2-octanediol with one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene to form an antiseptic disinfectant, wherein the weight ratio of said 1,2-octanediol to said one or more materials is between 0.5:1 and 10:1; and
adding the antiseptic disinfectant to a cosmetic and toiletries, medicine or food.

2. A method of using a cosmetic and toiletries, comprising the steps of:
providing an antiseptic disinfectant comprising
1,2-octanediol and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and β-pinene, wherein the weight ratio of said 1,2-octanediol to said one or more materials is between 0.5:1 and 10:1;
combining the antiseptic disinfectant with a cosmetically effective agent to form a cosmetic and toiletries; and
applying the cosmetic and toiletries to human or animal skin.

3. A method of using a medicine, comprising the steps of:
providing an antiseptic disinfectant comprising
1 ,2-octanediol, and
one or more materials selected from a group of thymol, eugenol, citronellal terpinyl acetate, citronellol and β-pinene, wherein the weight ratio of said 1,2-octanediol to said one or more materials is between 0.5:1 and 10:1;
combining the antiseptic disinfectant with a medicinally effective agent to form a medicine; and
applying the medicine to human or animal skin or administering the medicine to human or animal.

4. A method of using a food, comprising the steps of:
providing an antiseptic disinfectant comprising
1,2-octanediol, and
one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol, and β-pinene; wherein a weight ratio of said 1,2 -octanediol and said one or more materials is between 0.5:1 and 10:1
combining the antiseptic disinfectant with a nutritionally effective edible substance to form a food; and
feeding the food to human or animals.

5. A method of antiseptically disinfecting a cosmetic and toiletries, medicine or food, comprising the steps of:
providing an antiseptic disinfectant comprising
1,2-octanediol, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol, and β-pinene, wherein a weight ratio of said 1,2-octanediol and said one or more materials is between 0.5:1 and 10:1;
combining the antiseptic disinfectant with one selected from the group consisting of a cosmetically effective agent, a medicinally effective agent and a nutritionally effective edible substance.