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 Lecture on Determining the Genotype Frequency

January 9, 2019
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          Transcript
0:00 okay there's the formula you use and RC

0:03 - which is that yellow book

0:05 recommendation 4.1 they ask you to do a

0:08 correction on the homozygotes right

0:11 instead of just using P squared which is

0:13 hardy-weinberg they're telling you to

0:16 say P squared and then add that thing to

0:18 the right of it which is just P which is

0:22 the allele frequency for that locus

0:26 you're looking at times 1 minus the

0:29 allele frequency times 0.01 right so try

0:32 it say your allele frequency is 0.3

0:37 what's 0.3 squared is what wait oh 9

0:44 plus 0.3 times 0.7 is what point to 1

0:51 what's 0.2 1 times 0.01

0:56 just shift the decimal place and add

1:00 that it's a point o night when you get a

1:05 oh nine right

1:12 is that much different than point on

1:14 mine

1:17 so with common alleles it doesn't change

1:23 it much right so that if you have common

1:29 alleles and you add this correction

1:32 factor for population stratification or

1:35 population inbreeding which could lead

1:38 to a departure and hardy-weinberg

1:39 equilibrium if it existed for common

1:43 alleles it's not going to change it much

1:44 at all right why don't we correct

1:49 heterozygotes when you have inbreeding

1:53 you're increasing homozygosity okay so

1:57 what they're trying to do is we're

1:58 saying well if there is in breeding you

2:01 want to correct so that making the

2:06 homozygotes more common right to account

2:12 for possible in reading so what they're

2:14 saying is your population numbers that

2:18 you're calculating aren't accounting for

2:21 in breeding so they're too rare so you

2:26 got to make your homozygotes more common

2:28 to be more reflective if there was in

2:31 breeding you see that you're you're

2:35 increasing the frequency of the

2:38 homozygous as if there was one percent

2:41 in breeding your heterozygotes if there

2:47 was are going to be an overstatement of

2:49 what they should be
    
  
Disclaimer:
              Opinions or points of view expressed in these recordings represent those of the speakers and do not necessarily represent the official position or policies of the U.S. Department of Justice. Any commercial products and manufacturers discussed in these recordings are presented for informational purposes only and do not constitute product approval or endorsement by the U.S. Department of Justice.
  
Date Published: January 9, 2019
    
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