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                            Library & Multimedia
 Trace-Level Screening of Chemicals Related to Clandestine Desomorphine Production With Ambient Sampling, Portable Mass Spectrometry
NCJ Number
              255249
Journal

*Journal of Chemistry* Dated: 2017
Author(s)
          Seth E. Hall;
                        Adam E. O'Leary;
                        Zachary E. Lawton;
                        Allessandra M. Bruno;
                        Christopher C Mulligan
Date Published

2017
Length
              10 pages
Annotation
              This article presents the findings and methodology of a project that implemented desorption electrospray ionization (DESI) and paper spray ionization (PSI) on a portable mass spectrometer for the direct analysis of desomorphine and precursor reagent codeine from multiple substrates of potential relevance to clandestine drug laboratory synthesis and paraphernalia seizure.
Abstract
              Desomorphine is a semisynthetic opioid that is responsible for the psychoactive effects of a dangerous homemade injectable mixture that goes by street name "Krokodil." The validity of the method for its direct analysis was evaluated through the analysis of trace-level surface-bound residues, yielding low- to sub-ng detection limits from several substrates common to clandestine synthesis. Characteristic fragmentation similar to those reported in the literature and obtained on high-resolution MS instrumentation was achieved, providing confirmation of the target analytes. Due to the varying nature of forensic evidence with regard to chemical complexity, the applicability of the proposed method to multicomponent sample analysis was demonstrated, yielding high chemical specificity. Analysis of an authentic source of codeine precursor (in the form of prescription pharmaceutical tablets) was also demonstrated, supporting the proposed method's ability to directly analyze forensic evidence with minimal sample preparation. 4 figures,1 table, and 27 references (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2011-DN-BX-K552
                                2015-IJ-CX-K011


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Accessing the Probative Value of Physical Evidence at Crimes Scenes with Ambient Mass Spectrometry and Portable Instrumentation
                                Analytical Validation and Impact Assessment of On-Site Evidence Screening via Ambient Sampling, Portable Mass Spectrometry
    
  
  
Date Published: January 1, 2017
    
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                Clandestine laboratory enforcement programs
        Novel psychoactive substances
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