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                            Library & Multimedia
 Understanding Metal Inhibition: The Effect of Copper (Cu2+) on DNA Containing Samples
NCJ Number
              252341
Journal

*Forensic Chemistry* Volume: 4 Dated: June 2017 Pages: 89-95
Author(s)
          Liliana I. Moreno;
                        Bruce R. McCord
Date Published

June 2017
Length
              7 pages
Annotation
              This project examined whether copper ions in an evidence sample that contains DNA have adverse effects on DNA processing.
Abstract
              Copper wires are a common component of improvised explosive devices (IEDs) and are increasingly found in forensic evidence. When processed for DNA, ions from the metal can be co-extracted with the genetic material, and potentially cause complications during the analysis procedure. It was determined in this project that copper ions do have adverse effects on DNA processing by either interacting directly with the DNA or affecting the electrophoretic mobility of the molecule. It was also found that these negative effects could be improved by using a purification method capable of reducing the amount of copper carry-over into the sample. (Publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2010-DN-BX-K204


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Detection and remediation of PCR inhibition using real time PCR melt curves as a diagnostic tool.
    
  
  
Date Published: June 1, 2017
    
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      PatentsRelated Topics
        
                Degraded DNA samples
        DNA extraction
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