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                            Library & Multimedia
 Quantitative Analysis of Novel Synthetic Opioids, Morphine and Buprenorphine in Oral Fluid by LC-MS-MS
NCJ Number
              254077
Journal

*Journal of Analytical Toxicology* Volume: 42 Issue: 8 Dated: 2018 Pages: 554-561
Author(s)
          Michael. T. Truver;
                        Madeleine. J. Swortwood
Date Published

2018
Length
              8 pages
Publication Series
          BJA Implementation Manuals
Annotation
              This article presents the findings and methodology of a research project with the goal of developing and validating a comprehensive analytical method for the detection and quantification of morphine, 6-acetylmorphine, buprenorphine, U-47700, U-49900, U-50488, AH-7921, MT-45, W-18 and W-15 in oral fluid collected via Quantisal.
Abstract
              The opioid epidemic has become a national health emergency in the United States. Although heroin prescription opioid abuse is not uncommon, synthetic opioid use has risen dramatically, creating a public safety concern. Like traditional opioids, novel synthetic opioids are abused due to their analgesic and euphoric effects. Some adverse side effects include respiratory distress, nausea, and decreased consciousness. Synthetic opioids have emerged into the illicit and online drug market, including AH-7921, MT-45, U-series and W-series. Although originally developed by pharmaceutical companies, these substances are not well studied in humans, and comprehensive analytical methods for detecting and quantifying these opioids are limited. Oral fluid is a useful biological matrix for determining recent drug use, does not require a trained medical professional, and can be collected under direct observation, deterring adulteration. The current study used solid-phase extraction followed by liquid chromatography-tandem mass spectrometry to identify the specified designer drugs. The limits of detection and quantitation were 5 ng/mL and 10 ng/mL, respectively. Linearity was observed between 10 and 500 ng/mL (R2 0.9959). Bias and imprecision were <+/- 11.1 percent. Matrix effects ranged from 21.1 to 13.7 percent. No carryover was detected following injection of the highest calibrator. All analytes were stable (within +/- 15 percent change from baseline) under all tested conditions (24 h at room temperature, 72 h at 4 degrees C, and in the autosampler for 60 h at 4 degrees C). (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2017-R2-CX-0019


  
  
        
  Agencies
        NIJ


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Prevalence of Novel Psychoactive Substances in Oral Fluid
    
  
  
Date Published: January 1, 2018
    
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                Novel psychoactive substances
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