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                            Library & Multimedia
 Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) Variant
NCJ Number
              255390
Journal

*Annals of Human Genetics* Volume: 73 Dated: 2009 Pages: 335-345
Author(s)
          H Li;
                        S. Borinskaya;
                        K. Yoshimura;
                        N. Kal'ina;
                        A. Marusin;
                        et al
Date Published

2009
Length
              11 pages
Annotation
              In order to develop a highly refined global geographic distribution of the allele ALDH2*504Lys, the current project collected new data on 4,091 individuals from 86 population samples and assembled published data on 80,691 individuals from 366 population samples.
Abstract
              Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in human alcohol metabolism. The oriental ALDH2*504Lys variant functions as a dominant negative greatly reducing activity in heterozygotes and abolishing activity in homozygotes. This allele is associated with serious disorders such as alcohol liver disease, late onset Alzheimer disease, colorectal cancer, and esophageal cancer, and is best known for protection against alcoholism. Many hundreds of papers in various languages have been published on this variant, providing allele frequency data for many different populations. The allele is essentially absent in all parts of the world except East Asia. The ALDH2*504Lys allele has its highest frequency in Southeast China, and occurs in most areas of China, Japan, Korea, Mongolia, and Indochina with frequencies gradually declining radially from Southeast China. Since the indigenous populations in South China have much lower frequencies than the southern Han migrants from Central China, the current study concludes that ALDH2*504Lys was carried by Han Chinese as they spread throughout East Asia. Esophageal cancer, with its highest incidence in East Asia, may be associated with ALDH2*504Lys because of a toxic effect of increased acetaldehyde in the tissue where ingested ethanol has its highest concentration. Although the distributions of esophageal cancer and ALDH2*504Lys do not precisely correlate, that does not disprove the hypothesis. The study of fine-scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2007-DN-BX-K197


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Award
        Population Genetics of SNPs for Forensic Purposes
    
  
  
Date Published: January 1, 2009
    
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