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                            Library & Multimedia
 Speciation effects of solvent chemistry on the analysis of drugs and explosives by Electrospray Ion Mobility Mass Spectrometry
NCJ Number
              255729
Journal

*International Journal of Ion Mobility Spectrometry* Volume: 16 Dated: 2013 Pages: 237-246
Author(s)
          Howard Holness;
                        Jose R. Almirall
Date Published

2013
Length
              10 pages
Annotation
              This article examines research into whateffects solvent chemistry has on analytes being detected using electrospray ionization in ion mobility mass spectrometers.
Abstract
              The present work highlights the effect that solvent chemistry has on analytes being detected when utilizing electrospray ionization in ion mobility mass spectrometers. Various studies were conducted involving both positive and negative mode ionization. The enhancements observed by utilizing different levels of acid modifiers as well as the different ionic species of analytes being formed and detected are presented. The makeup of the electrospray solvent determined whether the ionic species would be protonated, sodium adducted, ammonium adducted, proton abstracted or chlorinated. Addition of solvent modifiers such as acids in the positive mode, and organic halides in the negative mode improved signal strength of analytes as well as improved spray characteristics that also decreased signal variability. The ability to perform simultaneous ionization of complex mixtures was also demonstrated through the use of solvent modifiers thereby allowing electrospray ionization ion mobility mass spectrometry the ability to simultaneously analyze complicated mixtures very quickly (millisecond separations). (Published Abstract Provided)
      
  
          Additional Details
Grant Number(s)
        2011-DN-BX-K531


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Separation and Identification of Drugs of Abuse Using ESI-IMS-MS
    
  
  
Date Published: January 1, 2013
    
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