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                            Library & Multimedia
 STRSeq: A Catalog of Sequence Diversity at Human Identification Short Tandem Repeat Loci
NCJ Number
              253223
Journal

*Forensic Science International-Genetics* Volume: 31 Dated: November 2017 Pages: 111-117
Author(s)
          Katherine B. Gettings;
                        Lisa A. Borsuk;
                        David Ballard;
                        Martin Bodner;
                        Bruce Budowle;
                        Laurence Devesse;
                        Jonathan King;
                        Walther Parson;
                        Christopher Phillips;
                        Peter M. Vallone
Date Published

November 2017
Length
              7 pages
Annotation
              This article profiles the STR Sequencing Project (STRSeq), which was initiated to facilitate the description of sequence-based alleles at the Short Tandem Repeat (STR) loci targeted in human identification assays.
Abstract
              This international collaborative effort, which has been endorsed by the ISFG DNA Commission, provides a framework for communication among laboratories. The initial data used to populate the project are the aggregate alleles observed in targeted sequencing studies across four laboratories: National Institute of Standards and Technology (N = 1786), Kings College London (N = 1043), University of North Texas Health Sciences Center (N = 839), and University of Santiago de Compostela (N = 944), for a total of 4612 individuals. STRSeq data are maintained as GenBank records at the U.S. National Center for Biotechnology Information (NCBI), which participates in a daily data exchange with the DNA DataBank of Japan (DDBJ) and the European Nucleotide Archive (ENA). Each GenBank record contains the observed sequence of a STR region, annotation ("bracketing") of the repeat region and flanking region polymorphisms, information regarding the sequencing assay and data quality, and backward compatible length-based allele designation. STRSeq GenBank records are organized within a BioProject at NCBI (https://www.ncbi.nlm.nih.gov/bioproject/380127), which is sub-divided into commonly used autosomal STRs, alternate autosomal STRs, Y-chromosomal STRs, and X-chromosomal STRs. Each of these categories is further divided into locus-specific BioProjects. The BioProject hierarchy facilitates access to the GenBank records by browsing, BLAST searching, or ftp download. Future plans include user interface tools at strseq.nist.gov, a pathway for submission of additional allele records by laboratories performing population sample sequencing and interaction with the STRidER web portal for quality control (http://strider.online). (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2015-DN-BX-K067
                                2016-DNR-6150


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Enhancing Mixture Interpretation with Highly Informative STRs
                                Development of NGS (next generation sequencing) nomenclature framework
    
  
  
Date Published: November 1, 2017
    
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