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                            Library & Multimedia
 STAT3 polymorphisms in North Africa and its implication in breast cancer
NCJ Number
              301794
Journal

*Molecular Genetics & Genomic Medicine* Volume: Online Dated: July 2021
Author(s)
          Wafa Ziadi;
                        Sami Boussetta;
                        Sarra Elkamel;
                        Andrew J. Pakstis;
                        Kenneth K. Kidd;
                        Imen Medimegh;
                        Amel Ben Ammar Elgaaied;
                        Lotfi Cherni
Date Published

July 2021
Length
              11 pages
Annotation
              Since only a few studies have investigated the association of single nucleotide polymorphisms in STAT3 gene with the susceptibility to cancer and response to chemotherapy, the goal of the current project was to determine the allele frequencies of rs3869550, rs957971, and rs7211777 at the STAT3 gene in North-African populations and compare them to 1000 genomes populations, and to investigate their relation with cancer.
Abstract
              The targeted SNPs have been analyzed in six Tunisian populations and a sample of Libyans using TaqMan® Assay. The results were compared to 1000 Genomes Project population samples. Targeting of the regions encompassing the three SNPs by micro-ARN was assessed using miR databases. The analysis of the 3 SNPs showed that North African populations were close to South Asians. As expected, African populations presented a significant frequency of the ancestral CCG haplotype in contrast to other populations where the fully derived TGA haplotype was more frequent. The presence and diversity of rare haplotypes at STAT3 in North African populations could have been generated by recombination between the two major haplotypes. A screening of the micro-RNA databases showed that the STAT3 region with the mutated allele of rs7211777 (G>A) could be targeted by miR hsa-miR-3606-5p, which also targets genes involved in breast cancer. 6 figures, 4 tables, and 44 references (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2018-75-CX-0041


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Award
        Better Forensic Markers: Microhaplotypes and Ancestry SNPs
    
  
  
Date Published: July 1, 2021
    
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