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                            Library & Multimedia
 SLLP1, A Unique, Intra-Acrosomal, Non-Bacteriolytic, C Lysozyme-like Protein of Human Spermatozoa
NCJ Number
              241199
Journal

*Biology of Reproduction* Volume: 68 Issue: 5 Dated: 2003 Pages: 1525-1537
Author(s)
          Arabinda Mandal;
                        Kenneth L. Klotz;
                        Jagathpala Shetty;
                        Friederike L. Jayes;
                        Michael J. Wolkowicz;
                        Laura C. Bolling;
                        Scott A. Coonrod;
                        Michael B. Black;
                        Alan B. Diekman;
                        Timothy A. J. Haystead;
                        Charles J. Flickinger;
                        John C. Herr
Date Published

2003
Length
              13 pages
Annotation
              This study investigated the presence of a unique c lysozyme-like protein in human spermatozoa.
Abstract
              During research that included mining of a human two-dimensional gel sperm proteome, scientists discovered the presence of several novel proteins including a unique c lysozyme-like protein identified as SLLP1. C lysozymes (chicken-type lysozymes) are N-acetylglucosamine-binding proteins that have not yet been identified as being present in human sperm. These proteins are important as they could play a possible role in sperm/egg adhesion during fertilization. This article describes the extraction and separation of sperm proteins from samples of human semen that tested negative by serology for HIV. The proteins were microsequenced and cloned, and a number of different analyses were conducted on the separated proteins. The study found that when antisera to SPPL1 were introduced, it blocked binding in the hamster egg penetration assay. This finding suggests that SPPL1 may have a role to play in binding the sperm to the egg during fertilization however; the specifics of this role will need to be examined in additional research. Tables, figures, and references
      
  
          Additional Details
Grant Number(s)
        2000-IJ-CX-K013
                                D43 TW/HD 00654
                                NIH HD U54 29099
                                P30 28934


  
  
        
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  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        SPERM CELL SELECTION SYSTEM FOR FORENSIC DNA OF THE MALE COMPONENT
    
  
  
Date Published: January 1, 2003
    
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