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                            Library & Multimedia
 Sub-Populations Within the Major European and African Derived Haplogroups R1b3 and E3a are Differentiated by Previously Phylogenetically Undefined Y-SNPs
NCJ Number
              241066
Journal

*Human Mutation* Volume: 97 Issue: 1 Dated: 2007 Pages: 1-7
Author(s)
          Lynn M. Sims;
                        Dennis Garvey;
                        Jack Ballantyne
Date Published

2007
Length
              7 pages
Annotation
              This study used a sample of 118 African-Americans and 125 European-Americans in evaluating 12 previously phylogenetically undefined Y-SNPs for their ability to further differentiate individuals who belong to the major African (E3a)-derived and European (R1b3, I)-derived haplogroups.
Abstract
              Major Y-SNP haplogroups were determined with 56 well-defined Y-SNPs, using a hierarchical typing strategy with the described pyrosequencing technology for genotyping. Ten of these markers define seven new subclades within haplogroups E and R. Using the Y Chromosome Consortium nomenclature, these new subclades are equivalent to E3a7a, E3a8, E3a8a, E3a8a1, R1b3h, R1b3i, and R1b3i1. During the study, the authors evaluated M222, a sub-Rib3 marker rarely used, and they found that this sub-haplogroup defines the Y-STR Irish Modal Haplotype (IMH). These new bi-allelic markers can be applied in human evolutionary studies and forensic genetics. The descriptions of materials and methods address candidate marker selection; genomic DNA isolation, PCR, and genotyping; and phylogenetic and statistical analysis. 1 table, 1 figure, and 25 references
      
  
          Additional Details
Grant Number(s)
        98-IJ-CX-K003
                                2005-MU-MU-K044


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Report (Study/Research)


  
  
        
  Award
        National Center for Forensic Science
    
  
  
Date Published: January 1, 2007
    
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