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                            Library & Multimedia
 SERS-based plasmonic nanobiosensing in single living cells
NCJ Number
              304485
Journal

*Analytical and Bioanalytical Chemistry* Volume: 393 Dated: 2009 Pages: 1135–1141
Author(s)
          Jonathan P. Scaffidi;
                        Molly K. Gregas;
                        Victoria Seewaldt;
                        Tuan Vo-Dinh
Date Published

2009
Length
              7 pages
Annotation
              This paper describes the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection.
Abstract
              The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized “normal” human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level. (Publisher Abstract)
      
  
          Additional Details
Grant Number(s)
        2006-DN-BX-K034


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Development of Advanced Raman Spectroscopy Methods and Databases for the Evaluation of Trace Evidence and the Examination of Questioned Documents
    
  
  
Date Published: January 1, 2009
    
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