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                            Library & Multimedia
 Quantitative Analysis of Desomorphine in Blood and Urine Using Solid Phase Extraction and Gas Chromatography-Mass Spectrometry
NCJ Number
              254105
Journal

*Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences* Volume: 1106 - 1107 Dated: February 2019 Pages: 43-49
Author(s)
          Jessica Winborn;
                        Sarah Kerrigan
Date Published

February 2019
Length
              7 pages
Annotation
              Since the lack of confirmed desomorphine reports may be in part due to the limited published analytical methodology capable of detecting desomorphine at forensically relevant concentrations, the goal of this study was to assist with identification efforts by developing and validating a robust analytical method.
Abstract
              Desomorphine, a semi-synthetic opioid, is a component of the street drug Krokodil. Despite continued reports of Krokodil use, confirmation via toxicological testing remains scarce. In the current project, Solid phase extraction (SPE) and gas chromatography-mass spectrometry (GC-MS) were used to determine desomorphine in blood and urine, using a deuterated analog as the internal standard. Data were acquired using selected ion monitoring (SIM) mode. Extraction efficiencies in blood and urine were 69 percent and 90 percent, respectively. The limits of quantitation in blood and urine were 5 ng/mL and 8 ng/mL, ten-fold lower than previously published methods. Intra- and inter-assay CVs were 2-4 percent (n=3) and 3-7 percent (n 15), respectively. The method was fully validated in accordance with published guidelines for forensic use, and it provides a means for identifying desomorphine in toxicology specimens at forensically relevant concentrations, without the need for derivatization. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2015-R2-CX-0031


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Metabolism and Analysis of Desomorphine
    
  
  
Date Published: February 1, 2019
    
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