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                            Library & Multimedia
 Selecting Microhaplotypes Optimized for Different Purposes
NCJ Number
              254331
Journal

*Electrophoresis* Volume: 38 Issue: 21 Dated: 2018 Pages: 2815-2823
Author(s)
          Kenneth K. Kidd;
                        Andrew J. Pakstis;
                        William C. Speed;
                        Robert Lagare;
                        Sharon Wootton;
                        Joseph Chang
Date Published

2018
Length
              9 pages
Annotation
              This article reports on a project that has conducted various DNA analyses for 83 populations in an ongoing study for a subset of the best microhaplotypes currently available, illustrating their characteristics and potential utility for ancestry, identification, and mixture deconvolution.
Abstract
              Massively parallel sequencing is transforming forensic work by allowing various useful forensic markers, such as STRPs and SNPs, to be multiplexed, providing information on ancestry, individual and familial identification, phenotypes for eye/hair/skin pigmentation, and the deconvolution of mixtures. Microhaplotypes also become feasible with massively parallel sequencing. These are DNA segments (smaller than 300 nucleotides) that are selected to contain multiple SNPs unambiguously defining three or more haplotype alleles occurring at common frequencies. The physical extent of a microhaplotype can thus be covered by a single sequence read, making these loci phase-known codominant genetic systems. Such microhaplotypes supply significantly more information than a single SNP. The project's efforts to develop useful sets of microhaplotypes have already identified 182 such loci that the project has studied on a large number of human populations from around the world. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2013-DN-BX- K023
                                2015-DN-BX-K023
                                2014-DN-BX-K030


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Continued Development of FROG-kb: A Forensic Resource/Reference on Genetics knowledge base
                                Powerful Forensic Markers Optimized for Massively Parallel Sequencing
    
  
  
Date Published: January 1, 2018
    
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