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                            Library & Multimedia
 Sex Determination Based on Raman Spectroscopy of Saliva Traces for Forensic Purposes
NCJ Number
              252348
Journal

*Analytical Chemistry* Volume: 88 Issue: 24 Dated: 2016 Pages: 12489-12493
Author(s)
          Claire K. Muro;
                        Luciana de Souza Fernandes;
                        Igor K. Lednev
Date Published

2016
Length
              5 pages
Annotation
              This project used Raman spectroscopy and multivariate data analysis to develop a nondestructive technique that could be used at a crime scene to determine the sex of a saliva donor.
Abstract
              The forensic analysis of body fluids has made great strides in recent years. Body fluids can easily be identified, and DNA analysis can be used to link a stain found at a crime scene to a specific person. When no reference DNA profile is available and the recovered DNA does not yield a match in a database, it would be useful if the evidence could still provide investigators with useful information. Biocatalytic and immunoassays can be used to determine a donor's sex, race, and other phenotypic characteristics; however, these tests depend on chemical reactions and are destructive to the sample. The current study's internally cross-validated classification model correctly identified 44 (92 percent) of the 48 donors used for model training. Subsequent external validation correctly identified 11 (92 percent) of the 12 donors saved for testing. This proof-of-concept study demonstrates the value of Raman spectroscopy as a forensic tool that can be used to elucidate phenotypic information about a body-fluid donor. Future studies will expand to other body fluids and additional donor characteristics, such as race and age. 1 graphical abstract (Publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2014-DN-BX-K016
                                2015-R2-CX-0019
                                2011-DN-BX-K551


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Raman spectroscopy for analyzing body fluid traces, stain aging, differentiation between races, genders and species
                                Raman spectroscopy for analyzing body fluid traces: Moving towards a practical forensic application
                                Further Development of Raman Spectroscopy for Body Fluid Investigation: Method Advancement and Validation
    
  
  
Date Published: January 1, 2016
    
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      PatentsRelated Topics
        
                Body fluid analysis
        Crime scene analysis
        DNA typing
        Forensic laboratories
        Forensic sciences



  
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