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                            Library & Multimedia
 STRait Razor v2s: Advancing Sequence-based STR Allele Reporting and Beyond to Other Marker Systems
NCJ Number
              252253
Journal

*FSI Genetics* Volume: 29 Dated: July 2017 Pages: 21-28
Author(s)
          Jonathan L. King;
                        Frank R. Wemdi;
                        Jie  Sun;
                        Bruce  Budowle
Date Published

July 2017
Length
              8 pages
Annotation
              This article describes the features and functions of STRait Razor, which has provided the forensic community a free-to-use, open-source tool for short tandem repeat (STR) analysis of massively parallel sequencing (MPS) data.
Abstract
              STRait Razor v2s (SRv2s) allows users to capture physically phased haplotypes within the full amplicon of both commercial (ForenSeq) and "early access" panels (PowerSeq, Mixture ID). STRait Razor v2s may be run in batch mode to facilitate population-level analysis and is supported by all Unix distributions (including MAC OS). Data are reported in tables in string (haplotype), length-based (e.g., vWA allele 14), and International Society of Forensic Genetics (ISFG)-recommended (vWA [CE 14]-GRCh38-chr12:5983950-5984049 (TAGA)10 (CAGA)3 TAGA) formats. STRait Razor v2s currently contains a database of ∼2500 unique sequences. This database is used by SRv2s to match strings to the appropriate allele in ISFG-recommended format. In addition to STRs, SRv2s has configuration files necessary to capture and report haplotypes from all marker types included in these multiplexes (e.g., SNPs, InDels, and microhaplotypes). To facilitate mixture interpretation, data may be displayed from all markers in a format similar to that of electropherograms displayed by traditional forensic software. The download package for SRv2s may be found at https://www.unthsc.edu/graduate-school-of-biomedical-sciences/molecular-and-medical-genetics/laboratory-faculty-and-staff/strait-razor. (Publisher abstract modirfied)
      
  
          Additional Details
Grant Number(s)
        2015-DN-BX-K067


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Report (Technical Assistance)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Enhancing Mixture Interpretation with Highly Informative STRs
    
  
  
Date Published: July 1, 2017
    
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