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                            Library & Multimedia
 Product Ion Tandem Mass Spectrometric Differentiation of Regioisomeric Side-Chain Groups in Cathinone Derivatives
NCJ Number
              251315
Journal

*Rapid Communications in Mass Spectrometry* Volume: 30 Issue: 14 Dated: July 2016 Pages: 1713-1721
Author(s)
          Y.  Abiedalla;
                        J.  DeRuiter;
                        C. R. Clark
Date Published

July 2016
Length
              9 pages
Annotation
              In this study, the propyl and isopropyl side-chain groups related to alpha-pyrrovalerone and MDPV were prepared and evaluated in electron ionization mass spectrometry (EI-MS) and tandem mass spectrometry (MS/MS) product ion experiments.
Abstract
              Precursor materials are available to prepare aminoketone drugs containing regioisomeric propyl and isopropyl side-chain groups related to the drug alpha-pyrrovalerone (Flakka) and MDPV (3,4-methylenedioxypyrrovalerone). These compounds yield equivalent regioisomeric iminium cation base peaks in electron ionization mass spectrometry (EI-MS). In the current study, deuterium labeling in both the pyrrolidine and alkyl side-chain groups allowed for the confirmation of the structures for the major product ions formed from the regioisomeric EI-MS iminium cation base peaks. These iminium cation base peaks show characteristic product ion spectra, which allow differentiation of the side-chain propyl and isopropyl groups in the structure. The n-propyl side chain containing iminium cation base peak (m/z 126) in the EI-MS spectrum yields a major product ion at m/z 84, and the regioisomeric m/z 126 base peak for the isopropyl side chain yields a characteristic product ion at m/z 70. Deuterium labeling in both the pyrrolidine ring and the alkyl side chain confirmed the process for the formation of these major product ions. The study concludes that product ion fragmentation provides useful data for differentiation of n-propyl and isopropyl side-chain iminium cations from cathinone derivative drugs of abuse. Regioisomeric n-propyl and isopropyl iminium cations of equal mass yield characteristic product ions identifying the alkyl side-chain regioisomers in the pyrrolidine cathinone derivatives. (Publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2013-DN-BX-K022


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Bath Salt-type Aminoketone designer Drugs: Analytical and Synthetic Studies on Substituted Cathinones
    
  
  
Date Published: July 1, 2016
    
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