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                            Library & Multimedia
 Male Genital Tract-Specific Carbohydrate Epitope on Human CD52: Implications for Immunocontraception
NCJ Number
              241178
Journal

*Tissue Antigens* Volume: 60 Issue: 5 Dated: 2002 Pages: 354-364
Author(s)
          E.J. Norton;
                        A.B. Diekman;
                        V.A. Westbrook;
                        D.W. Mullins;
                        K.L. Klotz;
                        L.L. Gilmer;
                        T.S. thomas;
                        D.C. Wright;
                        J. Brisker;
                        V.H. Engelhard;
                        C.J. Fligkinger;
                        J.C. Herr
Date Published

2002
Length
              11 pages
Annotation
              Western blotting and immunohistochemistry were performed in order to define the tissue distribution of the S19 epitope, which has been proposed as a target for immunocontraception.
Abstract
              The results support the use of the S19 epitope as a contraceptive immunogen and the suitability of the S19 mAb as an intravaginal contraceptive. The study determined that the S19 epitope is specific to tissues of the male reproductive tract, namely the epididymis and vas deferens, and it is absent from the human female reproductive tract and all somatic tissues tested to date. The findings support the view that S19 will be safe for use in the human female reproductive tract. The successful agglutination of spermatozoa with a formulation of the S19 native mAb conjugated to the Ovasome trilamellar liposome delivery vehicle demonstrated that the antibody could efficiently agglutinate spermatozoa in such a formulation. There was a clear demonstration of the maintenance of antibody activity when conjugated with a clinically proven delivery vehicle. It has been suggested that a reversible contraceptive vaccine would be the most effective solution to meet the multifaceted needs of today's society. In order to be an effective vaccine candidate, such an antigen should be tissue specific, involved in fertility, and able to raise a high antibody titer. The description of materials and methods addresses monoclonal antibodies, immunohistochemistry, FACS analysis, protein extract preparation, electrophoresis and immunoblot analysis, immunofluorescence microscopy, and sperm agglutination assay. 7 figures and 40 references
      
  
          Additional Details
Grant Number(s)
        2000-IJ-CX-K013


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Report (Study/Research)


  
  
        
  Award
        SPERM CELL SELECTION SYSTEM FOR FORENSIC DNA OF THE MALE COMPONENT
    
  
  
Date Published: January 1, 2002
    
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