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                            Library & Multimedia
 Relatedness Calculations for Linked Loci Incorporating Subpopulation Effects
NCJ Number
              246390
Journal

*Forensic Science International: Genetics* Volume: 7 Issue: 3 Dated: May 2013 Pages: 380-383
Author(s)
          Jo-Anne Bright;
                        James M. Curran;
                        John S. Buckleton
Date Published

May 2013
Length
              4 pages
Annotation
              Previously formulae have been given for both joint and conditional match probabilities for some relationships that did not account for subpopulation effects [1,2]. In this paper the researchers extend these works to include a subpopulation correction of the form first suggested by Balding and Nichols [3].
Abstract
              Often the loci in forensic multiplexes are selected to avoid linked loci. However linked loci have occurred in some recent commercially available multiplexes. Previously formulae have been given for both joint and conditional match probabilities for some relationships that did not account for subpopulation effects [1,2]. In this paper the researchers extend these works to include a subpopulation correction of the form first suggested by Balding and Nichols [3]. The researchers extend the work to grandparent/grandchild, first cousin, uncle/nephew and half uncle/nephew relationships and apply these to two different populations and STR multiplexes. The model assumes that the two people have no relationship other that the one specified. That is, the researchers assume their parents are neither related nor themselves inbred. The multiplications inherent in these formulae also assume that there is no linkage disequilibrium at the subpopulation level for these loci. The researchers found that when taking into account linkage the match statistic decreases for all relationships, with siblings having the greatest effect. However, the effect was less than a factor of two decreased in match statistic. (Published Abstract)
      
  
          Additional Details
Grant Number(s)
        2011-DN-BX-K541


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Report (Study/Research)


  
  
        
  Award
        Population Genetic Issues for Forensic DNA Profiles
    
  
  
Date Published: May 1, 2013
    
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