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                            Library & Multimedia
 Optimization of the qualitative and quantitative analysis of cocaine and other drugs of abuse via gas chromatography - Vacuum ultraviolet spectrophotometry (GC - VUV)
NCJ Number
              304850
Journal

*Talanta* Volume: 222 Dated: 2021
Author(s)
          Z. R. Roberson;
                        J. V. Goodpaster
Date Published

2021
Annotation
              Gas Chromatography-Vacuum UV Spectroscopy (GC-VUV) has seen increased attention in many areas; however, a statistical optimization of VUV method parameters has not been published, so this article presents the first statistical optimization of parameters influencing analytes such as cocaine in the VUV flow-cell.
Abstract
              Flow-cell temperature, make-up gas pressure, and carrier gas flow rate from the GC were examined and optimized for the detection of controlled substances. The accuracy, precision, linearity, and optimized detection limits for drugs such as cocaine (98.5%, 1.2%, 0.9998, 1.5 ng), heroin (99.3%, 0.94%, 0.9998, 2.0 ng), and fentanyl (98.5%, 1.7%, 0.9752, 9.7 ng) are reported. In general, the limits of detection for cocaine, heroin, fentanyl, and methamphetamine after optimization were comparable to gas chromatography-mass spectrometry (GC-MS) in “scan mode”, which had detection limits of 1.1–38 ng on column. The VUV absorption spectra of cocaine, PCP, lorazepam, and HU-210 are also reported. And three samples of “real world” cocaine are analyzed to demonstrate applicability to forensic drug analysis. (Publisher Abstract Provided)
      
  
          Additional Details
Grant Number(s)
        2017-R2-CX-0018


  
  
        
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  Award
        Coupling Gas Chromatography (GC) and Vacuum Ultraviolet (VUV) Spectroscopy for Forensic Applications
    
  
  
Date Published: January 1, 2021
    
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