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                            Library & Multimedia
 Rapid Re-identification of Human Samples Using Portable DNA Sequencing
NCJ Number
              253471
Journal

*ELife* Volume: 6 Dated: 2017
Author(s)
          Sophie Zaaijer;
                        Assaf Gordon;
                        Daniel Speyer;
                        Robert Piccone;
                        Simon C. Groen;
                        Yaniv Erlich
Date Published

2017
Length
              17 pages
Annotation
              This article describes a rapid, inexpensive, and portable strategy to robustly re-identify human DNA, called 'MinION sketching'.
Abstract
              DNA re-identification is used for a broad suite of applications, ranging from cell line authentication to forensics; however, current re-identification schemes suffer from high latency and limited access. In addressing this issue, MinION sketching requires as few as 3 minutes of sequencing and 60-300 random SNPs to re-identify a sample, enabling near real-time applications of DNA reidentification. The method used in the current project capitalizes on the rapidly growing availability of genomic reference data for cell lines, tissues in biobanks, and individuals. This empowers the application of MinION sketching in research and clinical settings for periodic cell line and tissue authentication. Importantly, this method enables considerably faster and more robust cell line authentication relative to current practices and could help to minimize the amount of irreproducible research caused by mix-ups and contamination in human cell and tissue cultures. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2014-DN-BX-K089


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Robust STR calling from High-throughput Sequencing Technologies
    
  
  
Date Published: January 1, 2017
    
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