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                            Library & Multimedia
 Rate of onset of dopamine transporter inhibitors assessed with intracranial self-stimulation and in vivo dopamine photometry in rats
NCJ Number
              306228
Journal

*PSYCHOPHARMACOLOGY* Volume: 240 Dated: 2023 Pages: 969–981
Author(s)
          Tyson R. Baird;
                        Kimberly N. Karin,;
                        Samuel A. Marsh;
                        F. Ivy Carroll;
                        J. M. L. Medina-Contreras;
                        S. Stevens Negus;
                        Jose M. Eltit
Date Published

2023
Length
              13 pages
Annotation
              This study compared intracranial self-stimulation (ICSS) effects produced in rats by three DA transporter inhibitors that have different rates of onset (fastest to slowest: cocaine, WIN-35428, RTI-31) and that produced progressively weaker metrics of abuse potential in a drug self-administration procedure in rhesus monkeys. Additionally, in vivo photometry using the fluorescent DA sensor dLight1.1 targeted to the nucleus accumbens (NAc) was used to assess the time course of extracellular DA levels as a neurochemical correlate of behavioral effects.
Abstract
              All three compounds produced ICSS facilitation and increased DA levels assessed by dLight. In both procedures, the rank order of onset rate was cocaine > WIN-35428 > RTI-31; however, in contrast to monkey drug self-administration results, maximum effects did not differ across compounds. These results provide additional evidence that drug-induced increases in DA drive ICSS facilitation in rats and illustrate the utility of both ICSS and photometry to evaluate the time course and magnitude of abuse-related drug effects in rats. (Published abstract provided)
      
  
          Additional Details
Grant Number(s)
        2019-R2-CX-0046


  
  
        
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  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        The Effects of Synthetic Cathinone Chirality on Pharmacodynamics and Pharmacokinetics and Its Implications for Forensic Toxicology
    
  
  
Date Published: January 1, 2023
    
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