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                            Library & Multimedia
 Raman Spectroscopy and Advanced Statistics for Biochemical Research and Analytical Purposes
NCJ Number
              256031
Journal

*Am. Pharmac. Review* Dated: May/June 2016 Pages: 44-48.1
Author(s)
          I. K. Lednev;
                        V. Sikirzhytski
Date Published

2012
Length
              5 pages
Annotation
              This article discusses the application of Raman spectroscopy combined with advanced statistical methods for characterizing complex (bio) chemical systems, which exhibit significant heterogeneity and variations from sample to sample.
Abstract
              As an example, the mechanism of YE8 polypeptide fibrillation, a complex dynamic system, was studied using 2-D correlation Raman spectroscopy. The evolution of secondary structure motifs with time was examined, and key stages of fibrillation, including the initiation process, were exposed. The application of multidimensional Raman spectroscopic signatures was proposed for the characterization and identification of complex (heterogeneous) nondynamic systems. The approach was successfully tested for forensic identification of body fluid stains. Blood, semen, saliva, sweat and vaginal fluid stains were extensively analyzed using NIR and Raman spectroscopy. The developed multidimensional signatures account for both the intrinsic heterogeneity of body fluid stains and variations between donors. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2011-DN-BX-K551


  
  
        
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        Raman spectroscopy for analyzing body fluid traces, stain aging, differentiation between races, genders and species
    
  
  
Date Published: January 1, 2012
    
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