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                            Library & Multimedia
 Measuring Rates of mtDNA Heteroplasmy and Assessing Transmission of Variants
NCJ Number
              252008

Author(s)
          Mitchell M. Holland
Date Published

December 2016
Length
              24 pages
Annotation
              This research project first established rates of heteroplasmy for the control region of the mtGenome through a massively parallel sequencing (MPS) analysis of 550 individuals of European ancestry, followed by the evaluation of the transmission of heteroplasmic sequence variants in three tissue types (blood and buccal cells and hair shafts) collected from multiple maternal lineages and, in one case, from an individual lineage across multiple generations.
Abstract
              Pipelines and software tools were developed for conducting a complete analysis of the data, which will be available to the forensic community before or at the end of the grant period. The researchers report that at least five publications will result from this project, with at least two additional papers directly tied to elements of the project. Each paper provides recommendations that the forensic community can use in developing best practices for implementing mtDNA MPS methods in their laboratories. The overall prediction of project researchers is that this project will have a significant impact on forensic mtDNA casework and the criminal justice system. Major sections of this report address the project's experimental design and methods, data analysis, findings, and criminal justice impact. Appended bibliography with 15 listings
      
  
          Additional Details
Grant Number(s)
        2014-DN-BX-K022


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Measuring Rates of  mtDNA Heteroplasmy and Assessing Transmission of Variants
    
  
  
Date Published: December 1, 2016
    
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