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                            Library & Multimedia
 Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer
NCJ Number
              301923
Journal

*Applied Spectroscopy* Volume: Online Dated: July 2021
Author(s)
          Ling Wang;
                        Mario O. Vendrell-Dones;
                        Chiara Deriu;
                        Sevde Dogruer;
                        Peter de B. Harrington;
                        Bruce McCord
Date Published

July 2021
Annotation
              This study involved the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system.
Abstract
              Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. The protocol of the current study was optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures was enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which enables the determination of fentanyl as low as 0.05 percent in simulated seized heroin and 0.10 percent in simulated seized cocaine samples. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2015-IJ-CX-K006
                                2014-DNR-4918
                                DJO-NIJ-21-RO-0002


  
  
        
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        NIJ-Sponsored


  
  
        
  Award
        The Application of Gold Nanoparticles for the Trace Detection of Synthetic Cannabinoids in Saliva and Urine by Surface Enhanced Raman Spectroscopy.
                                Interagency Collaboration to Support Forensic Science Research
                                NIJ Co-funding for the NSF Center for Advanced Research in Forensic Science (CARFS)
    
  
  
Date Published: July 1, 2021
    
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