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                            Library & Multimedia
 ProDerAl: reference position dependent alignment
NCJ Number
              302958
Journal

*Bioinformatics* Volume: 37 Issue: 16 Dated: August 2021 Pages: 2479–2480
Author(s)
          Benjamin Crysup;
                        Bruce Budowle;
                        August E Woerner
Date Published

August 2021
Length
              2 pages
Annotation
              This article considers the rationale for and the availability of the C++ program ProDerAl, which was written to refine previously generated alignments using varying parameters for these problematic regions, and synthetic benchmarks show that this realignment can result in an order of magnitude fewer misaligned bases.
Abstract
              Current read-mapping software uses a singular specification of alignment parameters with respect to the reference. In the presence of varying reference structures (such as the repetitive regions of the human genome), alignments can be improved if those parameters are allowed vary. Nix users can retrieve the source from GitHub (https://github.com/Benjamin-Crysup/proderal.git). Windows binary available at https://github.com/Benjamin-Crysup/proderal/releases/download/v1.1/proderal.zip. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2018-DU-BX-0177


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Better algorithms and chemistry for mixture interpretation
    
  
  
Date Published: August 1, 2021
    
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