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                            Library & Multimedia
 A panel of 74 AISNPs: Improved Ancestry Inference within Eastern Asia
NCJ Number
              308010
Journal

*Forensic Science International: Genetics* Volume: 23 Dated: 2016 Pages: 101-110
Author(s)
          Cai-Xia Li;
                        Andrew J. Pakstis;
                        Li Jiang;
                        Yi-Liang Wei;
                        Qi-Fan Sun;
                        Hong Wu;
                        Ozlem Bulbul;
                        Ping Wang;
                        Long-Li Kang;
                        Judith R. Kidd;
                        Kenneth. K. Kidd
Date Published

2016
Length
              10 pages
Annotation
              In this article, the authors describe their development of a new 74 ancestry informative SNP panel that can distinguish 10 groups of population globally, including Southeast and North Asia as newly assignable clusters.
Abstract
              Many ancestry informative SNP (AISNP) panels have been published. Ancestry resolution in them varies from three to eight continental clusters of populations depending on the panel used, however none of those panels differentiates well among East Asian populations. To meet this need, the authors have developed a 74 AISNP panel after analyzing a much larger number of SNPs for Fst and allele frequency differences between two geographically close population groups within East Asia. The 74 AISNP panel can now distinguish at least 10 biogeographic groups of populations globally: Sub-Saharan Africa, North Africa, Europe, Southwest Asia, South Asia, North Asia, East Asia, Southeast Asia, Pacific and Americas. Compared with our previous 55-AISNP panel, Southeast Asia and North Asia are two newly assignable clusters. For individual ancestry assignment, the likelihood ratio and ancestry components were analyzed on a different set of 500 test individuals from 11 populations. All individuals from five of the test populations – Yoruba (YRI), European (CEU), Han Chinese in Henan (CHNH), Rondonian Surui (SUR) and Ticuna (TIC) – were assigned to their appropriate geographical regions unambiguously. For the other test populations, most of the individuals were assigned to their self-identified geographical regions with a certain degree of overlap with adjacent populations. These alternative ancestry components for each individual thus help give a clearer picture of the possible group origins of the individual. The authors have demonstrated that the new AISNP panel can achieve a deeper resolution of global ancestry. Publisher Abstract Provided
      
  
          Additional Details
Grant Number(s)
        2013-DN-BX-K023


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        High resolution SNP panels for forensic identification of ancestry, family, and phenotype.
    
  
  
Date Published: January 1, 2016
    
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      PatentsRelated Topics
        
                Forensic sciences
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        Ancestry assessment



  
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