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                            Library & Multimedia
 The number of alleles in DNA mixtures with related contributors
NCJ Number
              305366
Journal

*Forensic Science International: Genetics* Volume: 61 Dated: November 2022
Author(s)
          Maarten Kruijver;
                        James M.Curran
Date Published

November 2022
Length
              6 pages
Annotation
              The maximum allele count (MAC) across loci and the total allele count (TAC) are often used to gauge the number of contributors to a DNA mixture. Computational strategies that predict the total number of alleles in a mixture arising from a certain number of contributors of a given population have been developed. Previous work considered the restricted case where all of the contributors to a mixture are unrelated.
Abstract
              We relax this assumption and allow mixture contributors to be related according to a pedigree. We introduce an efficient computational strategy. This strategy based on first determining a probability distribution on the number of independent alleles per locus, and then conditioning on this distribution to compute a distribution of the number of distinct alleles per locus. The distribution of the number of independent alleles per locus is obtained by leveraging the Identical by Descent (IBD) pattern distribution which can be computed from the pedigree. We explain how allelic dropout and a subpopulation correction can be accounted for in the calculations. (Publisher abstract provided)
      
  
          Additional Details
Grant Number(s)
        2020-DQ-BX-0022


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Population Genetic Issues for Forensic DNA Profiles
    
  
  
Date Published: November 1, 2022
    
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                Forensic sciences
        Evidence analysis and processing
        Forensic biology
        DNA (Deoxyribonucleic Acid)
        Mixed DNA profiles



  
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