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                            Library & Multimedia
 NIJ and CHORI: Collaboration With SoftGenetics and California Department of Justice - Customizing NextGENe Software for Forensic Applications
NCJ Number
              251474

Date Published

April 2016
Length
              2 pages
Annotation
              This paper discusses the features and benefits of a project that modified the NextGENe commercial software developed by SoftGenetics so as to improve the analysis of mitochondrial DNA (mtDNA) markers, which are ideal targets for analyzing degraded and mixed DNA samples.
Abstract
              Dr. Cassandra Calloway of Children's Hospital Oakland Research Institute (CHORI) recognized that NextGENe software offers a user-friendly, versatile program for the analysis of data generated by different massively parallel sequencing (MPS) platforms. Dr. Calloway led the NIJ-funded research effort with SoftGenetics to modify NextGENe software to improve analysis of mtDNA in a forensic context. This project yielded four benefits. First, it drives progress toward incorporation of mtDNA sequence analysis into the criminal justice system. Second, it supports missing person identification, analysis of degraded samples, and forensic profiling. Third, it adapts easily into current workflow in forensic labs with MPS equipment. Fourth, it enables quick, easy analysis of the data in comprehensive reports. The California Department of Justice has successfully used the modified NextGENe software in the identification of individuals in complex mixtures and degraded samples.
      
  
          Additional Details
Grant Number(s)
        2010-DN-BX-K141


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Technical Assistance)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description
                                Grants and Funding
                                Factsheet


  
  
        
  Award
        Resolution of DNA Mixtures and Analysis of Degraded DNA Using the 454 DNA Sequencing Technology
    
  
  
Date Published: April 1, 2016
    
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      PatentsRelated Topics
        
                Degraded DNA samples
        DNA contamination
        DNA typing
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        Forensic sciences



  
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