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                            Library & Multimedia
 Multi-allelic Exact Tests for Hardy-Weinberg Equilibrium that Account for Gender
NCJ Number
              255692
Journal

*Molecular Ecology Resources* Volume: 18 Issue: 3 Dated: 2018 Pages: 461-473
Author(s)
          Jan Graffelman;
                        Bruce. S. Weir
Date Published

2018
Length
              13 pages
Annotation
              Recently, the authors of this article proposed specific X-chromosomal exact test procedures for bi-allelic variants that include the hemizygous males, as well as autosomal tests that consider gender; and in the current study, they present the extension of the previous work for variants with multiple alleles.
Abstract
              Statistical tests for Hardy-Weinberg equilibrium are important elementary tools in genetic data analysis. X-chromosomal variants have long been tested by applying autosomal test procedures to females only, and gender is usually not considered when testing autosomal variants for equilibrium. In the current project, a full enumeration algorithm was used for the exact calculations of tri-allelic variants. For variants with many alternate alleles, the authors used a permutation test. Some empirical examples with data from the 1,000 genomes project are discussed. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2017-DN-BX-0136


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Population Genetic Issues for Forensic DNA Profiles
    
  
  
Date Published: January 1, 2018
    
          Downloads
        
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