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                            Library & Multimedia
 New Potent Synthetic Opioid—N-Desethyl Isotonitazene—Proliferating Among Recreational Drug Supply in USA
NCJ Number
              307415

Author(s)
          Alex J. Krotulski;
                        Jennifer Shinefeld;
                        Daniel Teixeria da Silva;
                        Amanda LA. Mohr;
                        Joshua DeBord;
                        Sara E. Walton;
                        Barry K. Logan
Date Published

2023
Annotation
              This announcement seeks to notify public health and public safety, law enforcement, clinicians, medical examiners and coroners, laboratory personnel, drug treatment providers, and other related communities about new information about the emergent synthetic opioid, N-desethyl isotonitazene.
Abstract
              This brief document provides information about the emergent synthetic opioid, N-desethyl isotonitazene, which has a structural resemblance to isotonitazene and the recently emergent nitazene analogues. N-Desethyl isotonitazene is dissimilar in chemical structure to fentanyl, although in vitro pharmacological data show that this molecule is approximately 20x more potent than fentanyl. This document provides a summary of N-desethyl isotonitazene, including facts about its emergence as well as structural analogues, toxicity, and adverse effects associated with the molecule. The announcement also notes geographical distribution in the U.S. along with a timeline of its discovery and spread; it depicts the structure of the N-desethyl isotonitazene molecule; and provides recommendations for public health, clinicians, medical examiners and coroners, and laboratories.
      
  
          Additional Details
Grant Number(s)
        2020-DQ-BX-0007


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)


  
  
        
  Award
        Real-Time Sample-Mining and Data-Mining Approaches for the Discovery of Novel Psychoactive Substances (NPS)
    
  
  
Date Published: January 1, 2023
    
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