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                            Library & Multimedia
 Micro Solid Phase Extraction Surface-Enhanced Raman Spectroscopy (mu-SPE/SERS) Screening Test for the Detection of the Synthetic Cannabinoid JWH-018 in Oral Fluid
NCJ Number
              254232
Journal

*Analytical Chemistry* Volume: 91 Issue: 7 Dated: 2019 Pages: 4780-4789
Author(s)
          Chiara Deriu;
                        Irene Conticello;
                        Alexander M Mebel;
                        Bruce McCord
Date Published

2019
Length
              10 pages
Annotation
              This article reports on an analytical protocol based on surface-enhanced Raman spectroscopy (SERS) and aimed at the detection of toxicologically relevant concentrations of JWH-018 in oral fluid.
Abstract
              A DFT-supported in-depth vibrational characterization of the drug in the solid state and in solution was also performed, providing a body of literature for future spectroscopic work on the compound. A Langmuir adsorption model was used to derive quantitative parameters such as the affinity of JWH-018 for citrate-capped gold nanospheres as well as the LOD. The application of the implemented method to the analysis of extracts from fortified oral fluid samples demonstrates the feasibility of SERS as an alternative to current immunoassays as a screening tool for use in emergency room settings. (publisher abstract modified)
      
  
          Additional Details
Grant Number(s)
        2015-IJ-CX-K006


  
  
        
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        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        The Application of Gold Nanoparticles for the Trace Detection of Synthetic Cannabinoids in Saliva and Urine by Surface Enhanced Raman Spectroscopy.
    
  
  
Date Published: January 1, 2019
    
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