EX-4.2



 Exhibit 4.2 
  

LUMENA PHARMACEUTICALS, INC. 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTOR
RIGHTS AGREEMENT (the “Agreement”) is entered into as of March 7, 2014, by and among LUMENA PHARMACEUTICALS, INC., a
Delaware corporation (the “Company”), and the entities listed on EXHIBIT A hereto (each, an “Investor” and together the “Investors”). 

RECITALS 

WHEREAS, in connection with the Company’s prior sale of its Series A Preferred Stock (the
“Series A Preferred”), the Company and certain of the Investors entered into an Investor Rights Agreement dated as of June 19, 2012 (as amended, the “Prior Agreement”); 

WHEREAS, the Investors are purchasing shares of the Company’s Series B Preferred Stock (the
“Series B Preferred”) pursuant to that certain Series B Preferred Stock Purchase Agreement (as the same may be amended from time to time, the “Purchase Agreement”) of even date herewith (the
“Financing”); 
 WHEREAS, pursuant to certain agreements for the acquisition
or licensing of technology or intellectual property by the Company the Company has issued to certain third parties shares of the Company’s Series A-1 Preferred Stock (the “Series A-1 Preferred”); 

WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and delivery of
this Agreement; and 
 WHEREAS, in connection with the consummation of the Financing, the parties
desire to enter into this Agreement in order to amend and restate the Prior Agreement and grant registration rights, information rights and other rights to the Investors as set forth below. 

NOW, THEREFORE, in consideration of these premises and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree that the Prior Agreement is amended and restated in its entirety as set forth herein: 

SECTION 1.        GENERAL. 

1.1           Definitions.    As used in
this Agreement the following terms shall have the following respective meanings: 

(a)        “Automatic Shelf Registration Statement”
shall have the meaning given to that term in SEC Rule 405. 

(b)        “Exchange Act” means the Securities
Exchange Act of 1934, as amended. 
 (c)        “Form
S-3” means such form under the Securities Act as in effect on the date hereof or any successor or similar registration form under the Securities Act subsequently 

  
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adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

(d)        “Holder” means any person owning of record
Registrable Securities that have not been sold to the public or any assignee of record of such Registrable Securities in accordance with Section 2.9 hereof. 

(e)        “Initial Offering” means the Company’s
first firm commitment underwritten public offering of its Common Stock registered under the Securities Act. 

(f)         “Qualified IPO” shall have the
meaning ascribed to such term in the Charter (as defined below). 

(g)        “Register,” “registered,” and
“registration” refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or
document. 
 (h)        “Registrable Securities”
means (a) Common Stock of the Company issuable or issued upon conversion of the Shares, (b) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as)
a dividend or other distribution with respect to, or in exchange for or in replacement of, such above-described securities and (c) any other Common Stock of the Company that may be held from time to time by the Investors. Notwithstanding the
foregoing, Registrable Securities shall not include any securities (i) sold by a person to the public either pursuant to a registration statement or Rule 144 or (ii) sold in a private transaction in which the transferor’s rights under
Section 2 of this Agreement are not assigned. 

(i)        “Registrable Securities then outstanding”
shall be the number of shares of the Company’s Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible securities. 

(j)        “Registration Expenses” shall mean all
expenses incurred by the Company in complying with Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and
disbursements not to exceed $50,000 of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular employees
of the Company which shall be paid in any event by the Company). 

(k)        “SEC” or
“Commission” means the Securities and Exchange Commission. 

(l)         “SEC Rule 405” means Rule 405
promulgated by the SEC under the Securities Act. 

(m)       “Securities Act” shall mean the Securities Act of
1933, as amended. 

  
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 (n)        “Selling
Expenses” shall mean all underwriting discounts and selling commissions applicable to the sale. 

(o)        “Shares” shall mean the Series A
Preferred, Series A-1 Preferred and Series B Preferred held from time to time by the Investors listed on Exhibit A hereto and their permitted assigns. 

(p)        “Special Registration Statement” shall mean
(i) a registration statement relating to any employee benefit plan or (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, any registration statements related to the issuance or resale
of securities issued in such a transaction or (iii) a registration related to stock issued upon conversion of debt securities. 

SECTION 2.     REGISTRATION; RESTRICTIONS ON TRANSFER. 

2.1         Restrictions on Transfer. 

(a)          Each Holder agrees not to make any disposition of all
or any portion of the Shares or Registrable Securities unless and until: 

(i)        there is then in effect a registration statement under the
Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or 

(ii)       (A) The transferee has agreed in writing to be bound by the terms of
this Agreement, (B) such Holder shall have notified the Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably
requested by the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is agreed that
the Company will not require opinions of counsel for transactions made pursuant to Rule 144, except in unusual circumstances. After its Initial Offering, the Company will not require any transferee pursuant to Rule 144 to be bound by the terms of
this Agreement if the shares so transferred do not remain Registrable Securities hereunder following such transfer. 

(b)          Notwithstanding the provisions of subsection
(a) above, no such restriction shall apply to a transfer by a Holder that is (A) a partnership transferring to its partners or former partners in accordance with partnership interests, (B) a partnership transferring to one or more
affiliated partnerships or funds managed by it or any of its respective directors, officers or partners, (C) a corporation transferring to a wholly-owned subsidiary or a parent corporation that owns all of the capital stock of the Holder,
(D) a limited liability company transferring to its members or former members in accordance with their interest in the limited liability company, or (E) an individual transferring to the Holder’s family member or trust for the benefit
of an individual Holder; provided that in each case the transferee will agree in writing to be subject to the terms of this Agreement to the same extent as if he were an original Holder hereunder. 

  
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 (c)        Each certificate
representing Shares or Registrable Securities shall be stamped or otherwise imprinted with legends substantially similar to the following (in addition to any legend required under applicable state securities laws): 

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE
“ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY
AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 
 THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF
THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A CERTAIN INVESTOR RIGHTS AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE COMPANY. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE
SECRETARY OF THE COMPANY. 
 (d)        The Company shall be obligated to
reissue promptly unlegended certificates at the request of any Holder thereof if the Company has completed its Initial Offering and the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably
acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of without registration, qualification and legend, provided that the second legend listed above shall be removed only at such
time as the Holder of such certificate is no longer subject to any restrictions hereunder. 

(e)        Any legend endorsed on an instrument pursuant to applicable state
securities laws and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 

2.2          Demand Registration. 

(a)        Subject to the conditions of this Section 2.2, if the Company
shall receive a written request from the Holders of at least 55% of the Registrable Securities (the “Initiating Holders”) that the Company file a registration statement under the Securities Act covering the registration of at
least 25% of the Registrable Securities then outstanding (or a lesser percent if the anticipated aggregate offering price, net of underwriting discounts and commissions, would exceed $10,000,000), then the Company shall, within 15 days of the
receipt thereof, give written notice of such request to all Holders, and, subject to the limitations of this Section 2.2, as soon as practicable, and in any event within sixty days after the date such request is given by the Initiating Holders,
file a Form S-1 registration statement under the Securities Act covering all 

  
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Registrable Securities that the Initiating Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders, and
effect, as expeditiously as reasonably possible, the registration under the Securities Act of all Registrable Securities that all Holders request to be registered. 

(b)          If the Initiating Holders intend to distribute the
Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include
such information in the written notice referred to in Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such
Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall
enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Holders of at least 55% of the Registrable Securities held by all Initiating Holders (which underwriter or underwriters
shall be reasonably acceptable to the Company). Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises the Company in writing that marketing factors require a limitation of the number of
securities to be underwritten (including Registrable Securities) then the Company shall so advise all Holders of Registrable Securities that would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the
underwriting shall be allocated to the Holders of such Registrable Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders); provided, however, that
the number of shares of Registrable Securities to be included in such underwriting and registration shall not be reduced unless all other securities of the Company are first entirely excluded from the underwriting and registration. Any Registrable
Securities excluded or withdrawn from such underwriting shall be withdrawn from the registration. 

(c)          The Company shall not be required to effect a
registration pursuant to this Section 2.2: 
 (i)        prior to the
earlier of (A) the fifth anniversary of the date of this Agreement or (B) of the expiration of the restrictions on transfer set forth in Section 2.11 following the Initial Offering; 

(ii)       after the Company has effected two registrations pursuant to this
Section 2.2, and such registrations have been declared or ordered effective; 

(iii)      during the period starting with the date of filing of, and ending on the date
180 days following the effective date of the Initial Offering, other than pursuant to a Special Registration Statement; provided that the Company makes reasonable good faith efforts to cause such registration statement to become effective;

 (iv)      if within 30 days of receipt of a written request from Initiating Holders
pursuant to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention to file a registration statement for a public offering, other than pursuant to a Special 

  
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Registration Statement within 90 days; provided that the Company makes reasonable good faith efforts to cause such registration statement to become effective; 

(v)        if the Company shall furnish to Holders requesting a registration
statement pursuant to this Section 2.2 a certificate signed by the Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company (the “Board”), it would be seriously detrimental
to the Company and its stockholders for such registration statement to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than 120 days after receipt of the request of the
Initiating Holders; provided that such right to delay a request shall be exercised by the Company not more than once in any 12 month period; 

(vi)        if the Initiating Holders propose to dispose of shares of
Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below. 

2.3          Piggyback Registrations.  The Company shall
notify all Holders of Registrable Securities in writing at least 15 days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to,
registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to include in such registration statement all or part of such
Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within 15 days after the above-described notice from the Company, so
notify the Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If a Holder decides not to include all of its Registrable Securities in any registration statement thereafter
filed by the Company, such Holder shall nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its
securities, all upon the terms and conditions set forth herein. 

(a)        Underwriting.  If the registration statement of which the
Company gives notice under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to include Registrable Securities in a registration
pursuant to this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing
to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision
of this Agreement, if the underwriter determines in good faith that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the
Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis; provided,
however, that no such reduction shall reduce the amount of securities of the selling Holders included in the registration below 30% of the total amount of securities included in such registration, unless such offering is the Initial Offering and


  
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such registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance with the
immediately preceding clause. In no event will shares of any other selling stockholder be included in such registration that would reduce the number of shares which may be included by Holders without the written consent of Holders of not less than
at least 55% of the Registrable Securities proposed to be sold in the offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter,
delivered at least 10 business days prior to the effective date of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a
partnership, limited liability company or corporation, the partners, retired partners, members, retired members and stockholders of such Holder, or the estates and family members of any such partners, retired partners, members and retired members
and any trusts for the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying
registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence. 

(b)          Right to Terminate Registration.  The Company
shall have the right to terminate or withdraw any registration initiated by it under this Section 2.3 whether or not any Holder has elected to include securities in such registration, and shall promptly notify any Holder that has elected to
include shares in such registration of such termination or withdrawal. The Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof. 

2.4          Form S-3 Registration.  In case the Company
shall receive from any Holder or Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3) or any similar short-form registration statement and any
related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company will: 

(a)          promptly give written notice of the proposed
registration, and any related qualification or compliance, to all other Holders of Registrable Securities; and 

(b)          as soon as practicable, effect such registration and
all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request,
together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within 15 days after receipt of such written notice from the Company; provided,
however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4: 

(i)        if Form S-3 is not available for such offering by the Holders;
or 

  
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 (ii)        if the Holders,
together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than $1,000,000; or

 (iii)       if within 30 days of receipt of a written request from any Holder
or Holders pursuant to this Section 2.4, the Company gives notice to such Holder or Holders of the Company’s intention to make a public offering within 90 days, other than pursuant to a Special Registration Statement; or 

(iv)       if the Company shall furnish to the Holders a certificate signed by the
Chairman of the Board stating that in the good faith judgment of the Board, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have
the right to defer the filing of the Form S-3 registration statement for a period of not more than 120 days after receipt of the request of the Holder or Holders under this Section 2.4; provided that such right to delay a request
shall be exercised by the Company not more than once in any 12 month period; or 

(v)        if the Company has, within the 12 month period preceding the date
of such request, already effected two registrations on Form S-3 for the Holders pursuant to this Section 2.4; or 

(vi)       in any particular jurisdiction in which the Company would be required to
qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 

(c)          Subject to the foregoing, the Company shall file a
Form S-3 registration statement covering the Registrable Securities and other securities so requested to be registered as soon as practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4
shall not be counted as demands for registration or registrations effected pursuant to Section 2.2. All Registration Expenses incurred in connection with registrations requested pursuant to this Section 2.4 after the first two
registrations shall be paid by the selling Holders pro rata in proportion to the number of shares to be sold by each such Holder in any such registration. 

2.5         Expenses of
Registration.      Except as specifically provided herein, all Registration Expenses incurred in connection with any registration, qualification or compliance pursuant to Section 2.2, 2.3 or 2.4 herein shall be
borne by the Company. All Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. The Company shall
not, however, be required to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon
material adverse information concerning the Company of which the Initiating Holders were not aware at the time of such request or (b) the Holders of at least 55% of Registrable Securities agree to deem such registration to have been effected as
of the date of such withdrawal for purposes of determining whether the Company shall be obligated pursuant to Section 2.2(c)(ii) or 2.4(b)(v), as applicable, to undertake any subsequent registration, in which event such right shall be forfeited
by all 

  
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Holders). If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting such registration
in proportion to the number of shares for which registration was requested. If the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a) above, then such registration shall not be deemed to have
been effected for purposes of determining whether the Company shall be obligated pursuant to Section 2.2(c)(ii) or 2.4(b)(v), as applicable, to undertake any subsequent registration. 

2.6         Obligations of the Company.    Whenever
required to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 

(a)        Prepare and file with the SEC a registration statement with respect
to such Registrable Securities and use all reasonable efforts to cause such registration statement to become effective, and, upon the request of the Holders of at least 55% of the Registrable Securities registered thereunder, keep such registration
statement effective for up to 120 days or, if earlier, until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written notice to the participating Holders and for a period not to
exceed 60 days thereafter (the “Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of any registration statement (and the Initiating
Holders hereby agree not to offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that there is or may be in existence material nonpublic information or
events involving the Company, the failure of which to be disclosed in the prospectus included in the registration statement could result in a Violation (as defined below). In the event that the Company shall exercise its right to delay or suspend
the filing or effectiveness of a registration hereunder, the applicable time period during which the registration statement is to remain effective shall be extended by a period of time equal to the duration of the Suspension Period. The Company may
extend the Suspension Period for an additional consecutive 30 days with the consent of the holders of at least 55% of the Registrable Securities registered under the applicable registration statement. No more than one such Suspension Period shall
occur in any 12 month period. In no event shall any Suspension Period, when taken together with all prior Suspension Periods, exceed 90 days in the aggregate. If so directed by the Company, all Holders registering shares under such registration
statement shall not offer to sell any Registrable Securities pursuant to the registration statement during the Suspension Period. Notwithstanding the foregoing, the Company shall not be required to file, cause to become effective or maintain the
effectiveness of any registration statement other than a registration statement on Form S-3 that contemplates a distribution of securities on a delayed or continuous basis pursuant to Rule 415 under the Securities Act. 

(b)        Prepare and file with the SEC such amendments and supplements to
such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration
statement for the period set forth in subsection (a) above. 

(c)        Furnish to the Holders such number of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other 

  
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documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

(d)        Use its reasonable best efforts to register and qualify the
securities covered by such registration statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith or as a
condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 

(e)        In the event of any underwritten public offering, enter into and
perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an
agreement. 
 (f)        Notify each Holder of Registrable Securities
covered by such registration statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as
then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company
will use reasonable efforts to amend or supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then existing. 

(g)        Use its reasonable best efforts to furnish, on the date that such
Registrable Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in
form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the independent certified public accountants of the Company, in
form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 

(h)        Use its commercially reasonable efforts to cause all such
Registrable Securities covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then
listed. 
 (i)        Provide a transfer agent and registrar for all
Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

(j)        After such registration statement becomes effective, notify each
selling Holder of any request by the SEC that the Company amend or supplement such registration statement or prospectus. 

  
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 (k)        To the extent the
Company is a well-known seasoned issuer (as defined in SEC Rule 405) at the time any request for registration is submitted to the Company in accordance with Section 3.1.2, if so requested, file an Automatic Shelf Registration Statement to
effect such registration. 
 (l)        If at any time when the Company is
required to re-evaluate its well-known seasoned issuer status for purposes of an outstanding Automatic Shelf Registration Statement used to effect a request for registration in accordance with Section 3.1.2 the Company determines that it is not
a well-known seasoned issuer and (i) the registration statement is required to be kept effective in accordance with this Agreement and (ii) the registration rights of the applicable Holders have not terminated, use commercially reasonable
efforts to promptly amend the registration statement on a form the Company is then eligible to use or file a new registration statement on such form, and keep such registration statement effective in accordance with the requirements otherwise
applicable under this Agreement. 
 2.7         Delay of Registration;
Furnishing Information. 
 (a)        No Holder shall have any right to
obtain or seek an injunction restraining or otherwise delaying any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

(b)        It shall be a condition precedent to the obligations of the Company
to take any action pursuant to Section 2.2, 2.3 or 2.4 that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such
securities as shall be required to effect the registration of their Registrable Securities. 

(c)        The Company shall have no obligation with respect to any
registration requested pursuant to Section 2.2 or Section 2.4 if the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or exceed the number of
shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable. 

2.8         Indemnification.    In the event any
Registrable Securities are included in a registration statement under Sections 2.2, 2.3 or 2.4: 

(a)        To the extent permitted by law, the Company will indemnify and hold
harmless each Holder, the partners, members, officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the
Securities Act or the Exchange Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or
alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary 

  
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prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated
therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the
Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration statement; and the Company will reimburse each such Holder, partner, member, officer, director, underwriter or controlling
person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the indemnity agreement contained in this
Section 2.8(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the
Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly
for use in connection with such registration by such Holder, partner, member, officer, director, underwriter or controlling person of such Holder. 

(b)        To the extent permitted by law, each Holder will, if Registrable
Securities held by such Holder are included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who
controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder’s partners, directors or officers or any person who controls
such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer or controlling person of such
other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any of the following
statements: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein or any
amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged
violation by the Company of the Securities Act (collectively, a “Holder Violation”), in each case to the extent (and only to the extent) that such Holder Violation occurs in reliance upon and in conformity with written
information furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will reimburse any legal or other expenses reasonably incurred by
the Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage,
liability or action if it is judicially determined that there was such a Holder Violation; provided, however, that the indemnity agreement contained in this Section 2.8(b) shall not apply to amounts paid in settlement of any such loss,
claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no event 

  
 12. 








 
shall any indemnity under this Section 2.8 exceed the net proceeds from the offering received by such Holder. 

(c)        Promptly after receipt by an indemnified party under this
Section 2.8 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.8, deliver to the
indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to
assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses thereof to be paid by the indemnifying
party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel
in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to the indemnified party under this
Section 2.8 to the extent, and only to the extent, prejudicial to its ability to defend such action, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any
indemnified party otherwise than under this Section 2.8. 

(d)        If the indemnification provided for in this Section 2.8 is
held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party thereunder,
shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the
indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s) or Holder Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations.
The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a
material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission;
provided that in no event shall any contribution by a Holder hereunder exceed the proceeds from the offering received by such Holder. 

(e)        The obligations of the Company and Holders under this
Section 2.8 shall survive completion of any offering of Registrable Securities in a registration statement and, with respect to liability arising from an offering to which this Section 2.8 would apply that is covered by a registration
filed before termination of this Agreement, such termination. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter into any
settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. 

  
 13. 








 2.9         Assignment of
Registration Rights.    The rights to cause the Company to register Registrable Securities pursuant to this Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities (for so long as such
shares remain Registrable Securities) that (a) is a subsidiary, parent, general partner, limited partner, retired partner, member or retired member, or stockholder of a Holder that is a corporation, partnership or limited liability company,
(b) is a Holder’s family member or trust for the benefit of an individual Holder, or (c) acquires at least 50,000 shares of Registrable Securities (as adjusted for stock splits and combinations), or (d) is an entity affiliated by
common control (or other related entity) with such Holder; provided, however, (i) the transferor shall, within 10 days after such transfer, furnish to the Company written notice of the name and address of such transferee or assignee and
the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set forth in this Agreement. 

2.10       Limitation on Subsequent Registration
Rights.    Other than as provided in Section 5.10, after the date of this Agreement, the Company shall not enter into any agreement with any holder or prospective holder of any securities of the Company that would grant
such holder rights to demand the registration of shares of the Company’s capital stock, or to include such shares in a registration statement that would reduce the number of shares includable by the Holders. 

2.11       “Market Stand-Off” Agreement.    Each
Holder hereby agrees that such Holder shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Common Stock (or
other securities) of the Company held by such Holder (other than those included in the registration) during the 180-day period following the effective date of the Initial Offering; provided that, all officers and directors of the Company and
holders of at least one percent of the Company’s voting securities are bound by and have entered into similar agreements. 

2.12       Agreement to Furnish Information.    Each Holder
agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriters that are consistent with the Holder’s obligations under Section 2.11 or that are necessary to give further effect
thereto. In addition, if reasonably requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within 10 days of such request, such information as may be
required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in
Section 2.11 and this Section 2.12 shall not apply to a Special Registration Statement. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to such shares of Common Stock (or other
securities) subject to the foregoing restriction until the end of such period. Each Holder agrees that any transferee of any shares of Registrable Securities shall be bound by Sections 2.11 and 2.12. The underwriters of the Company’s stock
are intended third party beneficiaries of Sections 2.11 and 2.12 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

  
 14. 








 2.13       Rule 144
Reporting.    With a view to making available to the Holders the benefits of certain rules and regulations of the SEC which may permit the sale of the Registrable Securities to the public without registration, the Company
agrees to use its best efforts to: 
 (a)        Make and keep public
information available, as those terms are understood and defined in SEC Rule 144 or any similar or analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an
offering of its securities to the general public; 
 (b)        File with
the SEC, in a timely manner, all reports and other documents required of the Company under the Exchange Act; and 

(c)        So long as a Holder owns any Registrable Securities, furnish to
such Holder forthwith upon request: a written statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting
requirements); a copy of the most recent annual or quarterly report of the Company filed with the Commission; and such other reports and documents as a Holder may reasonably request in connection with availing itself of any rule or regulation of the
SEC allowing it to sell any such securities without registration. 

2.14       Termination of Registration Rights.    The right of
any Holder to request registration or inclusion of Registrable Securities in any registration pursuant to Section 2.2, Section 2.3, or Section 2.4 hereof shall terminate upon the earlier of: (i) the date five years following an
initial public offering that results in the conversion of all outstanding shares of Preferred Stock; or (ii) such time as such Holder, as reflected on the Company’s list of stockholders, holds less than one percent of the Company’s
outstanding Common Stock (treating all shares of Preferred Stock on an as converted basis), the Company has completed its Initial Offering and all Registrable Securities of the Company issuable or issued upon conversion of the Shares held by and
issuable to such Holder (and its affiliates) may be sold pursuant to Rule 144 during any three-month period. Upon such termination, such shares shall cease to be “Registrable Securities” hereunder for all purposes. 

SECTION 3.    COVENANTS OF THE COMPANY. 

3.1         Matters Requiring Investor Director
Approval.    For so long as any shares of Series A Preferred or Series B Preferred remain outstanding, in addition to any other vote or consent required herein or by law, the vote or written consent of a majority of the
Board, including the Required Voting Preferred Director Consent (as defined in the Company’s Amended and Restated Certificate of Incorporation (as may be amended from time to time, the “Charter”)) shall be necessary for
effecting or validating the following actions: 
 (a)        any
Acquisition, Asset Transfer, or Liquidation Event (each as defined in the Charter); and 

(b)        any action to initiate or commence a clinical trial. 

3.2         Basic Financial Information and Reporting. 

  
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 (a)        The Company will
maintain true books and records of account in which full and correct entries will be made of all its business transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles
consistently applied (except as noted therein or as disclosed to the recipients thereof), and will set aside on its books all such proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied.

 (b)        So long as any Shares remain outstanding, as soon as
practicable after the end of each fiscal year of the Company, and in any event within 180 days thereafter, the Company will furnish any Investor holding together with its affiliates at least 2,500,000 shares of Series A Preferred or 2,500,000 shares
of Series B Preferred (each as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the date hereof) (each, a “Major Investor”) an audited balance sheet of the Company, as at the end of
such fiscal year, and an audited statement of income and an audited statement of cash flows of the Company, for such year, all prepared in accordance with generally accepted accounting principles consistently applied (except as noted therein or as
disclosed to the recipients thereof), and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial statements shall be accompanied by a report and opinion thereon by
independent public accountants of national standing selected by the Board. 

(c)        The Company will furnish each Major Investor, as soon as
practicable after the end of the first, second and third quarterly accounting periods in each fiscal year of the Company, and in any event within 60 days thereafter, an unaudited balance sheet of the Company as of the end of each such quarterly
period and an unaudited statement of income and statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles consistently applied (except as
noted therein or as disclosed to the recipients thereof), with the exception that no notes need be attached to such statements and year-end audit adjustments may not have been made, as well as an up-to-date capitalization table of the Company. 

(d)        The Company will furnish each Major Investor at least 30 days
prior to the beginning of each fiscal year an annual budget and operating plans for such fiscal year that each have been approved by the Board (and as soon as available, any subsequent written revisions thereto). 

3.3         Inspection Rights.    Each Major Investor
shall have the right to visit and inspect any of the properties of the Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information
as is reasonably requested all at such reasonable times and as often as may be reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.3 with respect to a competitor of the Company (and any
venture capital firm, financial investment firm or collective investment vehicle that is in the business of investing in entities shall under no circumstances be deemed to be a “competitor” solely as a result of its investments in an
entity in such a business) or with respect to information which the Board reasonably determines in good faith is highly confidential (unless covered by an enforceable confidentiality agreement, in form reasonably acceptable to the Company) or
attorney-client privileged and should not, therefore, be disclosed. 

  
 16. 








 3.4         Confidentiality of
Records.    Each Investor agrees to use the same degree of care as such Investor uses to protect its own confidential information to keep confidential any information furnished to such Investor pursuant to Sections 3.2
and 3.3 hereof that the Company identifies as being confidential or proprietary (so long as such information is not in the public domain), except that such Investor may disclose such proprietary or confidential information (i) to any former
partners who retained an economic interest in such Investor, current or prospective partner of the partnership or any subsequent partnership under common investment management, limited partner, general partner, member or management company of such
Investor, employee or representative of such Investor having a need to know the contents of such information, such Investor’s legal counsel, accountants or other professional advisors, subsidiary or parent of such Investor, in each case as long
as such party is advised of and agrees or has agreed to be bound by the confidentiality provisions of this Section 3.4 or comparable restrictions (including fiduciary or ethical obligations), (ii) at such time as it enters the public
domain through no fault of such Investor, (iii) that is communicated to it free of any obligation of confidentiality, (iv) that is developed by such Investor or its agents independently of and without reference to any confidential
information communicated by the Company, (v) to any prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees to be bound by the provisions of this Subsection and such prospective
purchaser is not a Competitor; or (vi) as required by applicable law. 

3.5         Reservation of Common Stock.    The
Company will at all times reserve and keep available, solely for issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

3.6         Proprietary Information and Inventions
Agreement.    The Company shall require all employees and consultants to execute and deliver a Proprietary Information and Inventions Agreement substantially in a form approved by the Company’s counsel or Board. 

3.7         Directors’ Liability and
Indemnification.    The Company’s Certificate of Incorporation and Bylaws shall provide (a) for elimination of the liability of director to the maximum extent permitted by law and (b) for indemnification of
directors for acts on behalf of the Company to the maximum extent permitted by law. 

3.8         Insurance.    The Company shall use
commercially reasonable efforts to maintain, from financially sound and reputable insurers, Directors and Officers liability insurance in an amount and on terms and conditions satisfactory to the Board (including the Required Voting Preferred
Director Consent), until such time as the Board (including the Required Voting Preferred Director Consent) determines that such insurance should be discontinued. The policy shall not be cancelable by the Company without prior approval of the Board.

 3.9         Employee Stock.    Unless
otherwise approved by the Board (including the Required Voting Preferred Director Consent), all future employees and consultants of the Company who receive options to purchase, or receive awards of, shares of the Company’s capital stock after
the date hereof shall be required to execute restricted stock or option agreements, as applicable, providing for (i) vesting of shares over a four (4) year period, with the first twenty-five percent (25%) of such shares vesting
following twelve (12) months of continued employment or service, and the remaining shares vesting in equal monthly installments over the 

  
 17. 








 
following thirty-six (36) months, (ii) a market stand-off provision substantially similar to that in Section 2.10 and (iii) a right of first refusal in favor of the Company on
transfers by each such employee or consultant substantially similar to that in the Company’s standard option agreement. 

3.10       Qualified Small Business.    For so long as any of
the Shares are held by an Investor (or a transferee in whose hands such Shares are eligible to qualify as “Qualified Small Business Stock” as defined in Section 1202(c) of the Internal Revenue Code of 1986, as amended (the
“Code”)), the Company will use its reasonable efforts to comply with the reporting and recordkeeping requirements of Section 1202 of the Code, any regulations promulgated thereunder and any similar state laws and
regulations. The Company shall submit to its stockholders (including the Investors) and to the Internal Revenue Service any reports that may be required under Section 1202(d)(1)(C) of the Code and the regulations promulgated thereunder. In
addition, within twenty (20) business days after any Investor’s written request therefor, the Company shall, at its option, either (i) deliver to such Investor a written statement indicating whether (and what portion of) such
Investor’s interest in the Company constitutes “qualified small business stock” as defined in Section 1202(c) of the Code or (ii) deliver to such Investor such factual information in the Company’s possession as is
reasonably necessary to enable such Investor to determine whether (and what portion of) such Investor’s interest in the Company constitutes “qualified small business stock” as defined in Section 1202(c) of the Code. 

3.11       FIRPTA.    The Company shall provide prompt notice to
New Enterprise Associates 14, Limited Partnership (“NEA 14”) following any “determination date” (as defined in Treasury Regulation Section 1.897-2(c)(1)) on which the Company becomes a United States real property
holding corporation. In addition, upon a written request by NEA 14, the Company shall provide NEA 14 with a written statement informing NEA 14 whether NEA 14’s interest in the Company constitutes a United States real
property interest. The Company’s determination shall comply with the requirements of Treasury Regulation Section 1.897-2(h)(1) or any successor regulation, and the Company shall provide timely notice to the Internal Revenue Service, in
accordance with and to the extent required by Treasury Regulation Section 1.897-2(h)(2) or any successor regulation, that such statement has been made. The Company’s written statement to NEA 14 shall be delivered to NEA 14 within
10 days of NEA 14’s written request therefor. The Company’s obligation to furnish such written statement shall continue notwithstanding the fact that a class of the Company’s stock may be regularly traded on an established
securities market or the fact that there is no preferred stock then outstanding. 

3.12       Indemnification Matters. 

(a)        The Company hereby acknowledges that the Voting Preferred Directors
(as defined in the Charter) may have certain rights to indemnification, advancement of expenses and/or insurance provided by one or more of the Investors and/or certain of its Affiliates (collectively, the “Fund
Indemnitors”). The Company hereby agrees (i) that it is the indemnitor of first resort (i.e., its obligations to the Voting Preferred Directors are primary and any obligation of the Fund Indemnitors to advance expenses or to
provide indemnification for the same expenses or liabilities incurred by the Voting Preferred Directors are secondary), (ii) that it shall be required to advance the full amount of expenses incurred by the Voting Preferred Directors and shall
be liable for the full amount of all expenses, judgments, penalties, fines and amounts paid in settlement by or on behalf of any such Voting Preferred Director to the extent 

  
 18. 








 
legally permitted and as required by the Charter or the Company’s Bylaws (or any agreement between the Company and the Voting Preferred Directors), without regard to any rights the Preferred
Directors may have against the Fund Indemnitors, and, (iii) that it irrevocably waives, relinquishes and releases the Fund Indemnitors from any and all claims against the Fund Indemnitors for contribution, subrogation or any other recovery of
any kind in respect thereof. The Company further agrees that no advancement or payment by the Fund Indemnitors on behalf of the Voting Preferred Directors with respect to any claim for which the Voting Preferred Directors has sought indemnification
from the Company shall affect the foregoing and the Fund Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of the Voting Preferred Directors against the
Company. If the Company or any of its successors or assignees consolidates with or merges into any other Person and is not the continuing or surviving corporation or entity of such consolidation or merger, then to the extent necessary, proper
provision shall be made so that the successors and assignees of the Company assume the obligations of the Company with respect to indemnification of members of the Board of Directors as in effect immediately before such transaction, whether such
obligations are contained in the Company’s Bylaws, its Certificate of Incorporation, or elsewhere, as the case may be. 

3.13       Termination of Covenants.    All covenants of the
Company contained in Section 3 of this Agreement (other than the provisions of Sections 3.4 and 3.7) shall expire and terminate as to Investors upon the earlier of (i) the effective date of the registration statement pertaining to an
Initial Offering that results in the Preferred Stock being converted into Common Stock or (ii) upon an Acquisition (as defined in the Charter). 

SECTION 4.    RIGHTS OF FIRST REFUSAL. 

4.1         Subsequent Offerings.    Subject to
applicable securities laws, each Major Investor shall have a right of first refusal to purchase its pro rata share of all Equity Securities (as defined below) that the Company may, from time to time, propose to sell and issue after the date
of this Agreement, other than the Equity Securities excluded by Section 4.6 hereof. Each Major Investor’s pro rata share is equal to the ratio of (a) the number of shares of the Company’s Common Stock (including all shares
of Common Stock issuable or issued upon conversion of the Shares) of which such Major Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s
outstanding Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) immediately prior to the issuance of the Equity Securities. The term “Equity Securities” shall mean (i) any
Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible into or exercisable or exchangeable for, with or without consideration, any Common Stock, Preferred Stock or other security (including any option to
purchase such a convertible security), (iii) any security carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security, or (iv) any such warrant or right. 

4.2         Exercise of Rights.    If the Company
proposes to issue any Equity Securities, it shall give each Major Investor written notice of its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Major
Investor shall have 15 days from the giving of such notice to agree to purchase its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the 

  
 19. 








 
notice by giving written notice to the Company and stating therein the quantity of Equity Securities to be purchased. Notwithstanding the foregoing, the Company shall not be required to offer or
sell such Equity Securities to any Major Investor if such offer or sale would cause the Company to be in violation of applicable federal securities laws by virtue of such offer or sale. 

4.3         Issuance of Equity Securities to Other
Persons.    If not all of the Major Investors elect to purchase their pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect and shall offer such
Major Investors the right to acquire such unsubscribed shares on a pro rata basis. The Major Investors shall have five days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the
unsubscribed shares. The Company shall have 90 days thereafter to sell the Equity Securities in respect of which the Major Investor’s rights were not exercised, at a price not lower and upon general terms and conditions not materially more
favorable to the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities within 90 days of the notice provided pursuant to
Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the Major Investors in the manner provided above. 

4.4         Termination of Rights of First
Refusal.    The rights of first refusal established by this Section 4 shall not apply to, and shall terminate upon the earlier of (i) the effective date of the registration statement pertaining to the Company’s
Initial Offering or (ii) an Acquisition. 
 4.5         Assignment of
Rights of First Refusal.    The rights of first refusal of Major Investors under this Section 4 may be assigned to the same parties and subject to the same restrictions as any transfer of registration rights pursuant to
Section 2.9. 
 4.6         Excluded
Securities.    The rights of first refusal established by this Section 4 shall have no application to any of the following Equity Securities: 

(a)        shares of Common Stock issued upon conversion of any shares of
Preferred Stock of the Company or as a dividend or other distribution on any shares of Preferred Stock of the Company; 

(b)        shares of Common Stock and/or options, warrants or other Common
Stock purchase rights and the Common Stock issued pursuant to such options, warrants or other rights (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the date hereof) issued or to be issued after the
date hereof to employees, officers or directors of, or consultants or advisors to the Company or any subsidiary, pursuant to stock purchase or equity incentive plans or other arrangements that are approved by the Board; 

(c)        any Equity Securities issued pursuant to any equipment loan or
leasing arrangement, real property leasing arrangement, or debt financing from a bank or similar financial or lending institution; provided that the issuance has been approved by the Board, including the Required Voting Preferred Director
Consent; 

  
 20. 








 (d)        any Equity Securities
issued for consideration other than cash pursuant to a merger, consolidation, acquisition or similar business combination; provided that the issuance has been approved by the Board, including the Required Voting Preferred Director Consent;

 (e)        stock issued or issuable pursuant to any rights or agreements,
options, warrants or convertible securities outstanding as of the date of this Agreement; and stock issued pursuant to any such rights or agreements granted after the date of this Agreement, so long as the rights of first refusal established by this
Section 4 were complied with, waived, or were inapplicable pursuant to any provision of this Section 4.6 with respect to the initial sale or grant by the Company of such rights or agreements; 

(f)        any Equity Securities issued in connection with any stock split,
stock dividend or recapitalization by the Company; 
 (g)        any Equity
Securities issued in connection with any strategic partnering or investment arrangement involving the Company and/or the acquisition or licensing of technology or intellectual property by the Company, in each such case as approved by the Board,
including the Required Voting Preferred Director Consent; 
 (h)        any
Equity Securities that are issued by the Company in connection with a firm commitment underwritten public offering pursuant to an effective registration statement under the Securities Act; 

(i)        any Equity Securities issued by the Company pursuant to the terms
of the Purchase Agreement; and 
 (j)        any Equity Securities that the
holders of at least 55% of the then-outstanding Registrable Securities (voting together on an as-converted basis) elect in writing to exclude from the definition of “Equity Securities” for purposes of this Section 4. 

SECTION 5.    MISCELLANEOUS. 

5.1         Governing Law.    This Agreement shall be
governed by and construed under the laws of the State of Delaware in all respects as such laws are applied to agreements among Delaware residents entered into and to be performed entirely within Delaware, without reference to conflicts of laws or
principles thereof. The parties agree that any action brought by either party under or in relation to this Agreement, including without limitation to interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to
and does hereby submit to the jurisdiction and venue of, any state or federal court located in the State of Delaware. 

5.2         Successors and Assigns.    Except as
otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the parties hereto and their respective successors, assigns, heirs, executors, and administrators and shall inure to the benefit of and be
enforceable by each person who shall be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the
full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its 

  
 21. 








 
records as the absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price. 

5.3         Entire Agreement.    This Agreement, the
Exhibits and Schedules hereto, the Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable
or bound to any other in any manner by any oral or written representations, warranties, covenants and agreements except as specifically set forth herein and therein. Each party expressly represents and warrants that it is not relying on any oral or
written representations, warranties, covenants or agreements outside of this Agreement. 

5.4         Severability.    In the event one or more
of the provisions of this Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement
shall be construed as if such invalid, illegal or unenforceable provision had never been contained herein. 

5.5         Amendment and Waiver. 

(a)        Except as otherwise expressly provided, this Agreement may be
amended or modified, and the obligations of the Company and the rights of the Holders under this Agreement may be waived, only upon the written consent of the Company and the holders of at least 55% of the then-outstanding Registrable Securities;
provided, however, that the amendment, modification or waiver of Sections 3.2, 3.3 and 4 shall require the written consent of the Company and the holders of at least 60% of the then-outstanding preferred stock of the Company held by all Major
Investors. 
 (b)        For the purposes of determining the number of
Holders or Investors entitled to vote or exercise any rights hereunder, the Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 

5.6         Delays or Omissions.    It is agreed that
no delay or omission to exercise any right, power, or remedy accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a
waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on
any party’s part of any breach, default or noncompliance under this Agreement or any waiver on such party’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically
set forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to any party, shall be cumulative and not alternative. 

5.7         Notices.    All notices required or
permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the
recipient; if not, then on the next business day, (c) five days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one day after deposit with a nationally


  
 22. 








 
recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the address as set forth on the
signature pages hereof or EXHIBIT A hereto or at such other address or electronic mail address as such party may designate by 10 days advance written notice to the other parties hereto. 

5.8        Attorneys’ Fees.   In the event that any suit or
action is instituted under or in relation to this Agreement, including without limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and
expenses of enforcing any right of such prevailing party under or with respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs
and expenses of appeals. 
 5.9        Titles and Subtitles.  The
titles of the sections and subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 

5.10      Additional Investors.    Notwithstanding anything to the
contrary contained herein, if the Company shall issue Equity Securities in accordance with Section 4.6 (c) or (d) of this Agreement, any purchaser of such Equity Securities may become a party to this Agreement by executing and
delivering an additional counterpart signature page to this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. 

5.11      Counterparts; Electronic or Facsimile Signatures.   This
Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument. This Agreement may be executed and delivered electronically or by facsimile and upon such
delivery such electronic or facsimile signature will be deemed to have the same effect as if the original signature had been delivered to the other party. 

5.12      Aggregation of Stock.   All shares of Registrable Securities
held or acquired by affiliated entities or persons or persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

5.13      Pronouns.   All pronouns contained herein, and any variations
thereof, shall be deemed to refer to the masculine, feminine or neutral, singular or plural, as to the identity of the parties hereto may require. 

5.14      Termination.  This Agreement shall terminate and be of no further
force or effect upon the earlier of (i) an Acquisition, or (ii) the date on which all rights and obligations set forth in Sections 2 through 4 have terminated pursuant to their terms. 

[THIS SPACE INTENTIONALLY LEFT BLANK] 

  
 23. 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	 COMPANY:

	
	LUMENA PHARMACEUTICALS, INC.
		
	 By:
	 	 /s/ Michael Grey



			
		
	 Name:
	 	 Michael Grey



			
		
	 Title:
	 	 Chief Executive Officer



 

			
	 Address:
	  	 12531 High Bluff Drive, Suite 110,

San Diego, CA 92130


  
  
  

 
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

					
	INVESTORS:
	
	NEW ENTERPRISE ASSOCIATES 14, L.P.
	BY: NEA PARTNERS 14, L.P., ITS GENERAL PARTNER
	BY: NEA 14 GP, LTD, ITS GENERAL PARTNER
			
	By:	 	/s/ Louis S. Citron	 	, Chief Legal Officer
	  
  
  

NEA VENTURES 2014, LIMITED PARTNERSHIP

			
	By:	 	/s/ Louis S. Citron	 	, its Vice-President
		
	 /s/ Elliott Sigal
	 	
	SIGAL FAMILY INVESTMENTS, LLC
		
	Elliott Sigal, Manager	 	

  
  
  

 
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

					
	INVESTOR:	  	
		
	ALTA PARTNERS VIII, L.P	  	
	BY: ALTA PARTNERS MANAGEMENT VIII, LLC	  	
	ITS: GENERAL PARTNER	  	

  
  

			
	By:	 	/s/ Larry Randall
		 	Chief Financial Officer

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
 INVESTORS: 

RIVERVEST VENTURE FUND II, L.P. 

BY: RIVERVEST VENTURE PARTNERS II, L.P., ITS
GENERAL PARTNER 
 BY: RIVERVEST VENTURE
PARTNERS II, LLC, ITS SOLE GENERAL PARTNER 
  

 

			
	By:	 	 /s/ John P. McKearn


			
	Name: John McKearn, Ph.D.
	Title: Authorized Person

  

RIVERVEST VENTURE FUND II (OHIO), L.P. 

BY: RIVERVEST VENTURE PARTNERS II (OHIO), LLC, ITS
GENERAL PARTNER 
 BY: RIVERVEST VENTURE
PARTNERS II, L.P., ITS SOLE MEMBER 
 BY:
RIVERVEST VENTURE PARTNERS II, LLC, ITS GENERAL PARTNER 
  

 

			
	By:	 	 /s/ John P. McKearn



			
	Name: John McKearn, Ph.D.
	Title: Authorized Person

  
  
  

 

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTORS:
	
	 A.M. PAPPAS LIFE SCIENCE
VENTURES IV, L.P.

	By:	 	AMP&A Management IV, LLC


			
		
	By:	 	/s/ Ford S. Worthy


			
	Name:	 	 Ford S. Worthy


			
	Title:	 	 Partner & CFO


			
		
	Address:	 	c/o Mr. Ford S. Worthy
		 	  Pappas Ventures

 2520 Meridian Parkway, Suite 400

 Durham, NC 27713



			
	
	PV IV CEO FUND, L.P.


			
	By:	 	AMP&A Management IV, LLC


			
		
	By:	 	/s/ Ford S. Worthy


			
	Name:	 	  Ford S. Worthy



			
	Title:	 	  Partner & CFO



			
		
	Address:	 	 c/o Mr. Ford S. Worthy
		 	   Pappas Ventures

  2520 Meridian Parkway, Suite 400

  Durham, NC 27713


  
  
  

 

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTOR:
	
	ADAGE CAPITAL PARTNERS, LP
		
	By:	 	/s/ D. Lehan


			
		
	Name:	 	D. Lehan


			
		
	Title:	 	COO

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTOR:
	
	RA CAPITAL HEALTHCARE FUND, LP
		
	By:	 	/s/ Peter Kolchinsky


			
	
	Name: Peter Kolchinsky
	
	Title: Manager

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTOR:
	
	GREENE FAMILY TRUST
		
	By:	 	/s/ Howard E. Greene Jr.


			
		
	Name:	 	 Howard E. Greene Jr.


			
		
	Title:	 	Trustee

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
 INVESTOR: 

LAWRENCE D. STERN 2010 QUALIFIED ANNUITY TRUST
AGREEMENT 
  

			
	By:	 	/s/ Lawrence D. Stern


			
		
	Name:	 	 Lawrence D. Stern


			
		
	Title:	 	Trustee

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTOR:
	
	GC&H INVESTMENTS, LLC
		
	By:	 	/s/ Jim Kindler


			
		
	Name:	 	Jim Kindler


			
		
	Title:	 	Manager

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

  
  

			
	INVESTOR:
	
	SATIOGEN PHARMACEUTICALS, INC.
		
	By:	 	/s/ Howard E. Greene Jr.


			
		
	Name:	 	 Howard E. Greene Jr.


			
		
	Title:	 	Chairman

  
  
  

 
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 








 EXHIBIT A 

INVESTORS 

ALTA PARTNERS VIII, L.P. 

One Embarcadero Center, 37th Floor 

San Francisco, CA 94111 

RIVERVEST VENTURE FUND II, L.P. 

7733 Forsyth Boulevard, Suite 1650 

St. Louis, MO 63105 

RIVERVEST VENTURE FUND II (OHIO), L.P. 

7733 Forsyth Boulevard, Suite 1650 

St. Louis, MO 63105 
 A.M.
PAPPAS LIFE SCIENCE VENTURES IV, L.P. 
 c/o Mr. Ford S. Worthy 

Pappas Ventures 
 2520 Meridian
Parkway, Suite 400 
 Durham, NC 27713 

PV IV CEO FUND, L.P. 

c/o Mr. Ford S. Worthy 

Pappas Ventures 
 2520 Meridian
Parkway, Suite 400 
 Durham, NC 27713 

GREENE FAMILY TRUST 

277 Crystal Drive 
 Frankfort, MI
49635 
 LAWRENCE D. STERN 2010 QUALIFIED ANNUITY TRUST
AGREEMENT 
 1540 Fox Chase Lane 

Pittsburgh, PA 15241 
 GC&H
INVESTMENTS, LLC 
 101 California Street 

5th Floor 

San Francisco, CA 94111-5800 

NEW ENTERPRISE ASSOCIATES 14, L.P. 

2855 Sand Hill Road 
 Menlo Park, CA
94025 

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 EXHIBIT A 








 NEA VENTURES 2014, LIMITED PARTNERSHIP 

2855 Sand Hill Road 
 Menlo Park, CA
94025 
 SIGAL FAMILY INVESTMENTS, LLC 

32 Brearly Road 
 Princeton, NJ
08540 
 ADAGE CAPITAL PARTNERS, LP 

200 Clarendon Street, 52nd Floor 

Boston, MA 02116 
 RA
CAPITAL HEALTHCARE FUND, LP 
 20 Park Plaza, Suite 1200 

Boston, MA 02116 

AVENTIS-HOLDINGS INC. 

3711 Kennett Pike, Suite 200 

Greenville, Delaware 19807 

PFIZER INC. 

575 Maryville Ctr. Dr. 
 St. Louis,
MO 63141 
 SATIOGEN PHARMACEUTICALS, INC. 

277 Crystal Drive 
 Frankfort, MI
49635 
  
  
  

  
 AMENDED AND RESTATED
INVESTOR RIGHTS AGREEMENT 
 EXHIBIT A