SmithKline Beecham
                                     Pharma

Facsimile Cover Sheet

To:               Don Easterbrook
Company:          Cryopak
Phone:

Fax:              604-685-9170

From:             Kate Ford
                  SB, Canada

Phone:            905-829-2030
Fax:              905-829-6060

Date:             29-Apr-97
Pages:            17

Comments:

Here's  the  proposed  information  booklet  (except  for the  "Recommendations"
section which I have to compose still). I changed some of the previous  sections
for clarity so let me know if it still makes sense. I decided not to include all
of the  cost  graphs  since  really  only the  Vancouver  to  Rixensart  data is
relevant.

Give me a call to discuss any changes you recommend.

Regards,

Kate

SmithKline Beecham Pharma Inc.
2030 Bristol Circle, Oakville, Ontario, Canada L6H5V2

<PAGE>

Section 1: Product Information
------------------------------

Cryopak offers  significant  advantages  for  maintaining  critical  temperature
ranges over conventional coolant products.

The patented  Cryopak  product  consists of sheets of  liquid-filled,  laminated
pouches that can be custom cut to various sizes or into individual Cubes for use
in a wide range of applications (see figure 1). The product is flexible, durable
and  provides  uniform  cooling  while  minimizing  the weight of the  shipment.
Cryopak  is  accepted  to be  packed  in  direct  contact  with all  temperature
sensitive  goods  (including  food  products) by the USDA,  FDA and  Agriculture
Canada.

The  product is  available  as a an ice  substitute  for  refrigeration  or as a
dry-ice  substitute for frozen  shipments.  This document will refer only to its
application as a reusable alternative to dry ice.

Advantages of this product over conventional dry ice shipments include:

         -- Safety

               - dry-ice  transforms from a solid to gaseous carbon dioxide thus
               is  considered  as a  dangerous  good  for air  transport  and is
               subject to government regulations

               - Cryopak does not have to be declared as a 'dangerous goods' for
               the  courier  thus  increasing  the  safety of the  shipment  and
               decreasing the paperwork required.

         -- Convenience

               - dry-ice has to be ordered from a supplier  each time a shipment
               is made.  There is often a surcharge  for delivery  since it is a
               'dangerous goods'.

               - Cryopak can be  conveniently  stored at the  hospital or clinic
               and placed in the freezer overnight before use

         -- Cost

               -  transportation   costs  can  he  reduced  through  weight  and
               packaging  reduction.  The  product can be reused,  thus  further
               reducing shipment costs.

The following pages outline specific analysis  performed for SmithKline  Beecham
for the shipping of frozen diagnostic specimens.


<PAGE>
                        Figure 1: Cryopak Product Formats

a) Cryomat sheets

         [Photograph of Cryomat sheets omitted from electronic filing]

b) Cryopak singles

         [Photograph of Cryomat singles omitted from electronic filing]

<PAGE>

                        SECTION II: PACKAGING VALIDATION

Three  tests  were  conducted  to  validate  the use of  Cryopak  product in the
shipping of frozen diagnostics specimens: a 'dry run' from Vancouver to Belgium,
and two simulated heat spikes under laboratory conditions.

A) Dry-Run (Vancouver to Rixensart to Toronto to Phoenix):
----------------------------------------------------------

Purpose of Test:
----------------

A mock  shipment was sent from  Vancouver  (on Canada's west coast) to Rixensart
(SB  Biologicals  lab in  Belgium)  to  demonstrate  the  ability of the Cryopak
product to remain frozen under normal courier and customs clearance  procedures.
The package was  returned  from  Rixensart  to Toronto for  confirmation  of the
results.  The package was then sent from Toronto to Phoenix for further  testing
at ISC (Insulated Shipping Containers, Inc.)

Materials:
----------

Standard  supplied used in SB Biologicals  clinical trials were employed for the
'dry-run' with the exception that the tuves contained water not sera and Cryomat
was substituted for dry-ice:

         -- 3  standard  SB  Styrofoarn  sera  racks -- 60  Sarstedt  sera tubes
         (containing 1-2 ml of water)

         --  Styrofoam  box  (dimensions  19.5 x 12.5 x 12.5  inches;  13/4 inch
         thickness) -- 25 lbs Cryornat L.T.- ( 12 mL size, custom cut sheets) --
         TempTale 3 Dry Ice Probe Monitor

Procedures:
-----------

1) The loaded racks and frozen  Cryomat L.T. were placed  within the  Styrofoarn
container  as  illustrated  in figure 2. The  TernpTale 3 main  logging unit was
placed on the exterior of the  Styrofoarn  container and the probe lead was then
placed into one vial within the sera rack.

2) The  container  was then shipped via Federal  Express  courier to  Rixensart,
Belgium.


<PAGE>

                                     CRYOPAK
                                   CORPORATION

                 Cryopak "Dry Specimen Run" March 5-13,1997 for
                         SMITHKLINE BEECHAM PHARMA INC.

                                         Test Details:

                                          1. EPS container
                                             ID: 19.5" x 12.5" x 12.5"
[Diagram of top view of
package deleted for electronic filing]    2. 4 Styrofoam Test Tube Holders, each
                                             containing 20 x 5 ml. vials, each
                                             containing 1-2 ml. water
[Diagram of side view of                  3. Product wrapped in frozen
package deleted for electronic filing]       Cryomat 12 ml. L.T.
                                          4. Total weight of Cryomat: 25 lbs.
                                          5. Total shipping weight 28.8 lbs.



                                                      Test No: 301062
                                                      Start Date: Mar 5,1997
                                                      Start Time: 14:11 PST
                                                      Log Interval: 15 min.
                                                      Test Criteria: <0C


<PAGE>

3) Once received at the Rixensart lab, the container was opened for  observation
and the product was placed into the freezer.  The  materials  sat in the freezer
over a weekend period of 66 hours.

4) The  materials  were brought out of the freezer and  reassembled  in the same
manner as illustrated in figure 2. The package was forwarded via Federal Express
to Toronto, Canada.

5) Once delivered to the SB office, the container was opened up for observation.
The probe was left at room  temperature  overnight  while the Cryomat  L.T.  and
materials were stored in a -70 C freezer.

6)  The  Cryomat  L.T.  and  materials  were  brought  out of  the  freezer  and
reassembled  in the same manner as in step 1,  inserting the probe lead into one
of the vials.

7) The container was forwarded via Federal Express to Phoenix, Arizona, USA.

8) Once delivered at Phoenix,  the container was opened for observation and then
all the  materials  were placed into a freezer until we started the 2 heat spike
tests outlined further in this report.


<PAGE>

Observations:

The tracking information provided by the courier (table 1) was correlated to the
internal  temperature of the package as monitored throughout the journey (figure
3).

<TABLE>
<CAPTION>
             Table 1: Pick-up and delivery times by Federal Express

Location                   Date             Time              Comments
--------                   ----             ----              --------
<S>                        <C>              <C>               <C>
Vancouver                  5/Mar/97         12:30 pm          product packaged
                                            15:02 pm          pick up by FedEx
                                            16:29 pm          outbound scan
Memphis                    6/Mar/97         2:39 am           inbound scan
                                            4:31 am           outbound scan
Brussels                   7/Mar/97         7:35 am           inbound scan
                                            8:06 am           outbound scan
Rixensart                  7/Mar/97         11:21 am          received by SB

Location                   Date             Time              Comments
Rixensart                  10/Mar/97        12:30 pm          product packaged
                                            13:01 pm          pick up by FedEx
Brussels                                    15:12 pm          outbound scan
Toronto                    11/Mar/97        7:35 am           inbound scan
Mississauga                                 9:35 am           inbound scan
Oakville                   11/Mar/97        11:36 am          received at SB

Location                   Date             Time              Comments
Oakville                   12/Mar/97        13:05 pm          product packaged
                                            15:01 pm          pick up by FedEx
Mississauga                                 20:00 pm.         outbound scan
Memphis                                     23:55 pm          inbound scan
                           13/Mar/97        4:01 am           outbound scan
Phoenix                                     6:28 am           inbound scan
                                            8:23 am           outbound scan
                           13/Mar/97        9:41 am           received by ISC

</TABLE>

<PAGE>


                                     CRYOPAK
                                   CORPORATION

                 Cryopak "Dry Run Specimen" March 5-13, 1000 for

                         SMITHKLINE BEECHAM PHARMA INC.

                         Using 25 lbs. Cryomat 12ml L.T.

The actual graph is too complex to be  electronically  reproduced,  but has been
submitted in paper format to the Securities and Exchange Commission.

The vertical axis starts at negative forty-five degrees celsius (C) and proceeds
at five degree  intervals up to 25 degrees C; the horizontal axis commences at 0
hours and  proceeds in three hour  increments  for an eight day  period.  Labels
underneath  this axis indicate that the first 40 hours  represent the Vancouver,
Canada,  to Risensart,  Belgium leg of the trip, the next 66 hours represent the
time in the freezer in Belgium,  the next 33 hours  consist of the transit  from
Belgium to Toronto,  Canada, followed by a section representing the time at room
temperature  in Toronto  and then in the  freezer  there,  and finally a 26 hour
section for the Toronto to Phoenix, Arizona trip. The graph line starts at about
1/3 of the way between - 10 and - 15 degrees C and almost immediately drops down
to - 25 degrees C before curving up slowly to 1/3 of the way between -10 degrees
C at the end of the transit to Belgium.  At this point, the graph spikes up to 0
degrees C very  abruptly  and then goes  immediately  down to just below the -25
degrees C mark,  where it wavers  between 2/3 and 3/4 of the way between -30 and
-25 degrees C for the  duration  of the time in the  freezer in Belgium.  At the
start of the trip to Toronto the graph line spikes up suddenly to just below -10
degrees  C, then  curves  suddenly  down to about half way  between  -20 and -15
degrees C before  climbing  gradually up to -10 degrees C at the end of the trip
to Toronto.  It then shoots up  immediately  to 20 degrees C at the beginning of
the room temperature period,  during which time it curves gradually down to just
above 15  degrees  C and then  climbs  slowly  back up to 20  degrees  C. At the
beginning of the freezer  section it  immediately  shoots down to just below -40
degrees C, then curves slowly upward during the trip to Phoenix, ending up about
half way between -15 and -10 degrees C.


<PAGE>

COST COMPARISON

The cost for the  shipment  from  Vancouver to  Rixensart  using  Cryomat LT was
compared to the  estimated  cost for the same  shipment  using 35 lbs (16 kg) of
dry-ice.  Figures 4 and 5  illustrate  the cost  comparison  and the  cumulative
savings  for 10  shipments.  A savings  of $29.90  was  estimated  for the first
shipment due to reduced  freight  charges with $73.65 saved for each  subsequent
shipment due primarily to the recycling of the Cryopak product.

CONCLUSIONS:

The Cryomat  maintained a temperature below -8.0 degrees C between each point of
departure and delivery to the recipient. The product appears to assure a uniform
transfer  of  heat  over  the   extended   period  of  time   required  for  air
transportation and to clear customs.

Although  the cost per pound is greater for the Cryornat  versus dry ice,  there
are  freight  savings  due to the  reduced  weight of coolant  required.  If the
Cryomat is roused for  gubsequent  shipments,  the  savings are  cumulative  and
eventually the product pays for itself.

Subsequent  testing was done to determine the effect of shipments  during higher
ambient temperatures (see figures 6-9).


<PAGE>


                                     CRYOPAK
                                   CORPORATION

Cryopak / Dry Ice Cost Comparison

Date:    March 5, 1997

Client: S.K.B."Dry Specimen Run" Vancouver - Rixensart

Referencing Insulated Container:            Test#301062
                  Length (in)       Width (in)       Height (in)
Outside           22.75             15.75            15.75
Inside            19.50             12.50            12.50

Container Cubic Measure (cu. ft.)                    3.27
Dimensional Package Weight (lbs)                     34.00    @ cu. in./lb. 166
         Actual Packaging Weight (lbs)               2.6
         Product Weight (lbs)                        1.20
         Dry Ice Weight (lbs)                        35.00
         Dry Ice Cost ($/lb)                         $1.01
         Cryomat Weight (lbs)                        25.00
         Ctyomat Cost ($/lb)                         $1.75
         Freight Rate ($/lb)                         $3.83

               Cryomat / Dry Ice Cost Comparison for 10 Shipments

Using 35.00 lbs of Dry Ice per shipment  reusing 25.00 lbs of Cryomat Rounded up
total shipping weight for: Dry Ice 39.00 lbs.

Cryomat 29.00 lbs.

<TABLE>
<CAPTION>
         Shipment          Dry lce Cost +            Cryomat Cost +             Cryomat          Savings Per
         Number            Freight Cost              Freight Cost               Savings          Shipment
         <S>               <C>                       <C>                        <C>              <C>
         0                 $0                        $0                         $0               $0
         1                 $184.72                   $154.82                    $29.90           $29.90
         2                 $369.44                   $265.89                    $103.55          $73.65
         3                 $554.16                   $376,96                    $177.20          $73.65
         4                 $738.88                   $488.03                    $250.95          $73.65
         5                 $923.60                   $599.10                    $324.50          $73.65
         6                 $1,108.32                 $710.17                    $398.15          $73.65
         7                 $1,293.04                 $821.24                    $471.80          $73.65
         8                 $1,477.76                 $932.31                    $545.45          $73.65
         9                 $1,662.48                 $1,043.38                  $619.10          $73.65
         10                $1,947.20                 $1.154.45                  $692.75          $73.65

</TABLE>


<PAGE>

                                     CRYOPAK
                                   CORPORATION

                         CRYOPAK/DRY ICE COST COMPARISON
                         Shipping 1 box for 10 shipments
<TABLE>
<CAPTION>

<S>               <C>      <C>      <C>     <C>      <C>      <C>      <C>      <C>     <C>
$2,000
                                                                                        x
$1,800                                                                                  x
                                                                                x       x
$1,600                                                                          x       x
                                                                       x        x       x
$1,400                                                                 x        x       x
                                                              x        x        x       x
$1,200                                                        x        x        x       x
                                                     x        x        x        x       x y
$1,000                                               x        x        x        x y     x y
                                            x        x        x        x y      x y     x y
$800                                        x        x        x y      x y      x y     x y
                                    x       x        x y      x y      x y      x y     x y z
$600                                x       x y      x y      x y      x y      x y z   x y z
                           x        x y     x y      x y      x y z    x y z    x y z   x y z
$400                       x        x y     x y      x y z    x y z    x y z    x y z   x y z
                  x        x y      x y     x y      x y z    x y z    x y z    x y z   x y z
                  x  y     x y      x y z   x y z    x y z    x y z    x y z    x y z   x y z
$200     x        x  y     x y      x y z   x y z    x y z    x y z    x y z    x y z   x y z
         x  y     x  y     x y      x y z   x y z    x y z    x y z    x y z    x y z   x y z
         x  y     x  y z   x y z    x y z   x y z    x y z    x y z    x y z    x y z   x y z
$0       x  y z   x  y z   x y z    x y z   x y z    x y z    x y z    x y z    x y z   x y z
         1        2        3        4       5        6        7        8        9       10
</TABLE>

x = dry ice cost + freight cost
y = Cryomat cost + freight cost
z = Cryomat savings

<PAGE>

B) SIMULATED HEAT SPIKE - TEST 0326974A (CRYOMAT LOW TEMPERATURE):

Purpose:
--------

To simulate the  performance  of Cryomat LT in maintaining  sub-zero  centigrade
temperatures under extreme ambient temperatures for more than 48 hours.

Materials:
----------

The same supplies as in the 'dry run' were used:
         3 standard SB Styrofoam. sera racks
         60 Sarstedt sera tubes (containing 1-2 ml of water)
         Styrofoam  box  (dimensions  19.5  x  12.5 x  12.5  inches;  13/4  inch
         thickness) 25 lbs Cryomat L.T.- ( 12 mL size, custom cut sheets)

In addition,  an  environmental  chamber,  fluke data logger and type-T  thermal
couples were used.

Procedures:
-----------

The  procedure  was  carried  out  on our  behalf  by  ISC  (Insulated  Shipping
Containers  Inc.). The sera tubes,  racks,  probes and CryomAt were assembled in
the  Styrofoam  container  as per  figure 6. The  package,  was then  subject to
ambient  profiling  of 22'C for 18 hours  followed  by VC for 6 hours.  This was
repeated for a total of 72 hours.

Observations:
-------------

The results of the  temperature  cycling are illustrated in figure 7. CTyomat LT
(25 lbs) maintained a temperature below O*C for 52.5 hours

Conclusions:
------------

The heat spike  simulation  mimics a 'worst  case'  scenario  for  shipping  the
package.

For example the package could be subjected to:

         -room temperature for 18 hours before pick-up by the courier
         -  then  transported  by  ground  to  the  airport  for  6  hours  in a
         non-refrigerated  truck (in a 35'C heat wave) - then transported for 18
         hours at room  temperature due to delays at the airport or in customs -
         then  transported by ground to the destination ( at 350C) - the package
         is then received and stored at room temperature before freezing

Although  this  scenario is very  unlikely,  it is  reassuring  to know that the
contents  of the  package  would  still  remain less than 0 degrees C under such
stringent conditions.


<PAGE>
                                 TEST WORKSHEET

[DIAGRAM OF TOP OF PACKAGE WITH     Notes:
PROBE POSITIONS INDICATED HAS       Cryopak SmithKline Freeze Test
BEEN DELETED FROM EDGARIZED         1.  EPS container ID: 19.5" x 12.5" x 12.5"
VERSION]                                4 Styrofoam Test Tube Holders
                                    2.  Each Holder contains 20 x 5mL fill vials
                                    3.  Product frozen at -30 degrees C
                                    4.  Product encapsulated in frozen
                                        Cryomat 12mL L.T.
                                    5.  Cryomat 12mL L.T. frozen at -30 C
                                    6.  Total weight of Cryomat: 25 lbs.

                                                  Test No: 0326974A
[DIAGRAM OF SIDE VIEW                             Start Date/Time: 3/26/97  3:22
OF PACKAGE WITH PROBE                             Gel Initial Temp:  -28.6 C
POSITIONS INDICATED HAS BEEN                      Performed by: JOW
DELETED FROM EDGARIZED                            Verified by: MG
VERSION]                                          Datalogger: Omega
                                                  Log Interval: 30 minutes
                                                  Temp. Criteria: > 0 degrees C
                                                  Test Type: Design
                                                  Chamber No.: 2
                                                  Job No. 561
                                                  Total Weight: 28.8 lbs.

Test Observations          ISC - Insulated Shipping    Ambient Conditions
                           Containers, Inc.
N.B. L.T. Cryomat 12 mL    Customer: SKB/Cryopak       22 degrees C for 18 hours
Low Temperature Product    Drawn by: M. Gorton         35 degrees C for 6 hours
                           Drawing No. Cryo561a        Repeat for 96 hours
<PAGE>



                                     CRYOPAK
                                   CORPORATION

                 Cryopak Heat Spike Laboratory Test 0326974A for
                         SMITHKLINE BEECHAM PHARMA INC.
                         Using 25 Lbs. Cryomat 12mL L.T.


The actual graph is too complex to be  electronically  reproduced,  but has been
submitted in paper format to the Securities and Exchange Commission.

The vertical axis starts at negative  fifty degrees  celsius (C) and proceeds at
ten degree  intervals  up to 40 degrees C; the  horizontal  axis  commences at 0
hours and proceeds in two hour increments for 72 hours. The Ambient  temperature
line  has a note  attached  to it that it is a  programmed  cycle of 22 C for 18
hours and 35 C for 6 hours and the graph line represents this pattern. The lines
for the three  probes  follow  very  similar  routes - all start  about half way
between -10 and -20 degrees C, jump down  almost  immediately  to just above -30
degrees C, then curve slowly upward;  reaching 0 degrees C at about 52 hours. At
this point, two of the probe lines jump up to halfway between 0 and 10 degrees C
at the 54 hour mark and then slope  upwards,  ending  halfway  between 10 and 20
degrees C at 72 hours. The third probe line continues at 0 degrees C until about
59 hours,  then jumps up quickly in a 1 hour period to just over halfway between
0 and 10 degrees C before sloping  upwards and ending halfway  between 10 and 20
degrees C at 72 hours.

<PAGE>

C) SIMULATED HEAT SPIKE - TEST 04109873A (CRYOPAK L.T. SINGLES):

Purpose:
--------

To  simulate  the  performance  of Cryopak LT  singles in  maintaining  sub-zero
centigrade  temperatures  under extreme  ambient  temperatures  for more than 48
hours.

Materials:
----------

as per previous test but using 25 lbs of Cryopak singles (vs. Cryomat)

Methods:
--------

The  procedure  was  carried  out  on our  behalf  by  ISC  (Insulated  Shipping
Containers  Inc.).  The sera  tubes,  racks,  probes and  Cryopak  singles  were
assembled  in the  styrofoam  container  as per figure 8. The  package  was then
subject to ambient profiling of 22 degrees C for 18 hours followed by 35 degrees
C for 6 hours. This was repeated for a total of 72 hours.

Observations:
-------------

The results of the  temperature  cycling are illustrated in figure 9. Cryopak LT
singles (25 lbs) maintained a temperature  below 0 degrees C for greater than or
equal to 56.5 hours (range:  56.5 to 71.5 hours  depending on positioning of the
probe).

Conclusions:
------------

The  Cryopak  singles  were  equally  as  efficient  at  maintaining  a sub-zero
temperature during extreme ambient temperatures as was the Cryomat format.


<PAGE>

TEST WORKSHEET

[DIAGRAM OF TOP OF PACKAGE WITH     Notes:
PROBE POSITIONS INDICATED HAS       Cryopak SmithKline Freeze Test
BEEN DELETED FROM EDGARIZED         1.  EPS container ID: 19.5" x 12.5" x 12.5"
VERSION]                                4 Styrofoam Test Tube Holders
                                    2.  Each Holder contains 20 x 5mL fill vials
                                    3.  Product frozen at -30 degrees C
                                    4.  Product encapsulated in frozen
                                        Cryomat 12mL L.T. Singles
                                    5.  Cryomat 12mL L.T. Singles frozen at
                                        -30 C
                                    6.  Total weight of Cryomat: 25 lbs.

                                         Test No: 0410973A
[DIAGRAM OF SIDE VIEW                    Start Date/Time: 4/10/97     4:00
OF PACKAGE WITH PROBE                    Gel Initial Temp:  -33.2 C
POSITIONS INDICATED HAS BEEN             Performed by: MG
DELETED FROM EDGARIZED                   Verified by: MG
VERSION]                                 Datalogger: Fluke 1
                                         Log Interval: 30 minutes
                                         Temp. Criteria: > 0 degrees C
                                         Test Type: Design
                                         Chamber No.: 2
                                         Job No. 561
                                         Total Weight: 28.8 lbs.

Test Observations          ISC - Insulated Shipping  Ambient Conditions
                           Containers, Inc.
N.B. L.T. Cryomat 12 mL    Customer: SKB/Cryopak     22 degrees C for 18 hours
Low Temperature Product    Drawn by: M. Gorton       35 degrees C for 6 hours
                           Drawing No. Cryo561a      Repeat for 96 hours

<PAGE>

                                     CRYOPAK
                                   CORPORATION

                   Cryopak Heat Spike Laboratory Test 0410973A
                       for SMITHKLINE BEECHAM PHARMA INC.

                     Using 25 Lbs. Cryomat 12mL L.T. Singles


The actual graph is too complex to be  electronically  reproduced,  but has been
submitted in paper format to the Securities and Exchange Commission.

The vertical axis starts at negative  fifty degrees  celsius (C) and proceeds at
ten degree  intervals  up to 40 degrees C; the  horizontal  axis  commences at 0
hours and proceeds in two hour increments for 72 hours. The Ambient  temperature
line  has a note  attached  to it that it is a  programmed  cycle of 22 C for 18
hours and 35 C for 6 hours and the graph line represents this pattern. The lines
for the three probes follow very similar  routes.  All three start at just below
-20 degrees C and jump  immediately  down to between -40 and -50 degrees C, with
one line slightly below the other two. All three lines curve upwards, each a few
degrees  apart from each other,  with one reaching -10 degrees C at 26 hours and
the other two reaching that temperature at 28 hours. The three lines continue to
slope very slowly  upward so that one line is half way between -10 and 0 degrees
C at 44 hours and the other two are 1/3 of the way between  those two degrees at
that time.  The higher  probe line  reaches 0 degrees C at 56.5 hours,  where it
remains  constant  until just  before 66 hours,  then climbs up suddenly to just
under 10 degrees C at the 72 hour mark. The second line separates from the third
one just  after the 52 hour mark and  reaches 0 degrees C at  between  58 and 60
hours,  remaining there until just after 70 hours and then climbing  suddenly to
just over halfway between 0 and 10 degrees C at the 72 hour mark. The third line
hits 0 degrees C at the 64 hour mark and  remains  their  constantly  until just
before 72 hours,  when it jumps up to approximately 1/3 of the way between 0 and
10 degrees C.