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                            Library & Multimedia
 MicroCantilever (MC) based Robust Sensing Approach for Controlled Substances
NCJ Number
              236173

Author(s)
          George  Kraus;
                        Marit  Nilsen-Hamilton;
                        Pranav  Shrotriya;
                        Kyungho  Kang;
                        Aaron  Kempema;
                        Ashish  Sachan
Date Published

October 2011
Length
              65 pages
Annotation
              This grant-funded research report introduced the use of MicroCantilever (MC) based sensors for forensic detection and identification of controlled substances, toxic species, biological molecules and DNA matching.
Abstract
              MicroCantilever (MC) based sensors can provide revolutionary sensitivity for forensic detection and identification of controlled substances, toxic species, biological molecules and DNA matching. Current sensor systems require extensive sample preparation and/or specialized instrumentation to identify molecules of controlled substances such as cocaine with high specificity and sensitivity. The authors aim to overcome the limitations of current sensor systems by developing a novel sensing approach based on MC sensors coupled with aptamer-based receptor layers. To demonstrate the feasibility and forensic suitability of their approach, the authors developed sensors for sensitive and specific identification of cocaine, cocaine metabolites, and methamphetamine and metabolites. These objectives were accomplished through the completion of tasks arranged in two phases so that knowledge and experience gained in the first phase may be utilized for successful completion of the second phase. In the first phase of the project, presented in this report, the authors: 1) Optimized the available DNA aptamer to improve its sensitivity for binding with cocaine; 2) Characterized the sensitivity and specificity of MC-based sensors functionalized with an available DNA aptamer that has specific affinity for cocaine; and 3) Initialed the selection of additional variant DNA aptamers with selective sensitivities to cocaine and its metabolites.
      
  
          Additional Details
Grant Number(s)
        2008-DN-R-038


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Report (Study/Research)


  
  
        
  Award
        MicroCantilever (MC) based Robust Sensing Approach for Controlled Substances
    
  
  
Date Published: October 1, 2011
    
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