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                            Library & Multimedia
 Long-term Stability of Synthetic Cannabinoids in Biological Matrices
NCJ Number
              254677

Author(s)
          Katherine Bollinger;
                        Nichole Bynum;
                        Megan Grabenauer
Date Published

April 2020
Length
              39 pages
Annotation
              This is the Final Summary Report on the methodology and findings of a research project with the objective of providing the forensic community with a comprehensive investigation of synthetic cannabinoids of different core structures and their major metabolites regarding their short-term and long-term stability in both urine and whole blood; and a secondary objective was to provide laboratories with efficient extraction and analytical methods for synthetic cannabinoids and metabolites.
Abstract
              The project validated two liquid chromatography/tandem mass spectrometry (LC-MS/MS) methods for the quantitative identification of 29 synthetic cannabinoids and 25 synthetic cannabinoid metabolites. Boston University validated 17 synthetic cannabinoids in blood (Group 1a) and 10 metabolites in urine (Group 2a). RTI International validated 12 synthetic cannabinoids in blood (Group 1b and 15 metabolites in urine (Group 2b). UR144 and XLR11 in blood and UR144 5-hydroxypentyl and AB-FUBINACA M2A metabolites in urine were validated at both institutions in evaluating stability for an interlaboratory comparison. Research results address several of the National Institute of Justice's (NIJ's) Technology Working Group's operational requirements for scientific research, technology development, policy or protocol development, assessment and evaluation, and the dissemination and/or training of specific research. Analytical and extraction methods have been publicized to the forensic community through presentations at various conferences. This research also informed the forensic community of appropriate collection and handling protocols for samples that contain or are suspected of containing synthetic cannabinoids. This information will be useful in the future for new compounds that result from minor modifications that produce new structural analogs. Extensive tables and figures
      
  
          Additional Details
Grant Number(s)
        2016-DN-BX-0191


  
  
        
  Agencies
        NIJ-Sponsored


  
  
        
  Publication Type
        Research (Applied/Empirical)
                                Report (Summary)
                                Report (Study/Research)
                                Report (Grant Sponsored)
                                Program/Project Description


  
  
        
  Award
        Long-term Stability of Synthetic Cannabinoids in Biological Matrices
    
  
  
Date Published: April 1, 2020
    
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