[Federal Register Volume 61, Number 23 (Friday, February 2, 1996)]
[Notices]
[Pages 4188-4196]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 96-1721]




[[Page 4187]]

_______________________________________________________________________

Part VIII





Environmental Protection Agency





_______________________________________________________________________



Thirty-Seventh Report of the TSCA Interagency Testing Committee to the 
Administrator; Receipt of Report, Request for Comments, Solicitation of 
Use and Exposure Data; Notice

Federal Register / Vol. 61, No. 23 / Friday, February 2, 1996 / 
Notices 

[[Page 4188]]


ENVIRONMENTAL PROTECTION AGENCY

[OPPTS-41044; FRL-4991-6]


Thirty-Seventh Report of the TSCA Interagency Testing Committee 
to the Administrator; Receipt of Report, Request for Comments, 
Solicitation of Use and Exposure Data

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The TSCA Interagency Testing Committee (ITC), established 
under section 4(e) of the Toxic Substances Control Act (TSCA), 
transmitted its 37th Report to the Administrator of the EPA on November 
22, 1995. In its 37th Report, which is included with this notice, the 
ITC revised the Priority Testing List by adding a group of 28 
alkylphenols and alkylphenol ethoxylates to the List for consideration 
by the EPA Administrator for promulgation of test rules under section 
4(a) of the Act. The ITC also removed 43 previously-recommended 
silicone chemicals and 5 isocyanates. The ITC's reasons for removing 
these chemicals from the List are described in the 37th Report. As 
noted in this Report, the ITC is soliciting use and exposure data for 9 
of the 12 High Production Volume Chemicals that were recommended in its 
36th Report (60 FR 42982, August 17, 1995) and consumer use and data 
for the 10 isocyanates remaining on the List. There are no designated 
or recommended with intent-to-designate chemicals or chemical groups in 
the 37th Report. EPA invites interested persons to submit written 
comments on the Report.

DATES: Written comments on the 37th ITC Report should be submitted by 
March 4, 1996.

ADDRESSES: Comments on the 37th Report should be submitted to both the 
ITC and the TSCA Public Docket. Send one copy of written submissions 
to: John Walker, ITC Director, U.S. EPA (7401), 401 M St. SW., 
Washington, DC 20016. Send six copies of written submissions to: TSCA 
Public Docket Office (7407), Office of Pollution Prevention and Toxics, 
Environmental Protection Agency, Rm. B-607 NEM, 401 M St. SW., 
Washington, DC 20460. Submissions should bear the document control 
number (OPPTS-41044; FRL-4991-6).
    The public record supporting this action, including comments, is 
available for public inspection in Rm. B-607 NEM at the address noted 
above from 12:00 noon to 4 pm Monday through Friday, except legal 
holidays.

FOR FURTHER INFORMATION CONTACT:  Susan B. Hazen, Director, 
Environmental Assistance Division (7408), Office of Pollution 
Prevention and Toxics, Environmental Protection Agency, 401 M St. SW., 
Rm. ET-543B,Washington, DC 20460, (202) 554-1404, TDD (202) 554-0551.

SUPPLEMENTARY INFORMATION: EPA has received the TSCA Interagency 
Testing Committee's 37th Report to the Administrator.

I. Background

    TSCA (Pub. L. 94-469, 90 Stat. 2003 et seq; 15 U.S.C. 260l et seq.) 
authorizes the Administrator of the EPA to promulgate regulations under 
section 4(a) requiring testing of chemicals and chemical groups in 
order to develop data relevant to determining the risks that such 
chemicals and chemical groups may present to health or the environment. 
Section 4(e) of TSCA established the Interagency Testing Committee 
(ITC) to recommend chemicals and chemical groups to the Administrator 
of the EPA for priority testing consideration. Section 4(e) directs the 
ITC to revise the TSCA section 4(e) Priority Testing List at least 
every 6 months. The most recent revisions to this List are included in 
the ITC's 37th Report. The Report was received by the Administrator on 
November 22, 1995, and is included in this Notice. The Report 
recommends a group of 28 alkylphenols and alkylphenol ethoxylates, 
removes 43 silicone chemicals and 5 isocyanates previously recommended 
for testing and solicits use and exposure data for 9 High Production 
Volume Chemicals (HPVCs) and 10 isocyanates from the TSCA section 4(e) 
Priority Testing List.

II. Status of List

    The ITC's 37th Report requests use and exposure data for 9 HPVCs 
and 10 isocyanates, adds 28 chemicals to and removes 48 chemicals from 
the Priority Testing List. The current TSCA section 4(e) Priority 
Testing List contains 5 chemicals and 9 chemical groups; of these 3 
chemical groups and 3 chemicals were designated for testing.
    A notice will be published at a later date in the Federal Register 
adding certain of the substances recommended in the ITC's 37th Report 
to the TSCA section 8(d) Health and Safety Data Reporting Rule (40 CFR 
Part 716), which requires the reporting of unpublished health and 
safety studies on the listed chemicals. That notice will also add some 
of the chemicals to the TSCA section 8(a) Preliminary Assessment 
Information Rule (40 CFR part 712). The section 8(a) rule requires the 
reporting of production volume, use, exposure, and release information 
on the listed chemicals.

III. Electronic and Oral Comments

    The EPA invites interested persons to submit detailed comments on 
the ITC's Report. A record has been established for this notice under 
docket number [OPPTS-41044]. A public version of this record including 
printed paper versions of electronic comments, which does not contain 
any information claimed as confidential business information (CBI), is 
available for inspection from 12 noon to 4 p.m., Monday through Friday, 
excluding legal holidays. The public record is located in the TSCA Non-
confidential Information Center, Rm. NE-B607, 401 M St., SW., 
Washington, DC 20460. Electronic comments can be sent directly to the 
ITC at

W<a href="/cdn-cgi/l/email-protection#7c1d1017190e5216131412183c190c1d111d151052190c1d521b130a"><span class="__cf_email__" data-cfemail="41202d2a24336f2b2e292f25012431202c20282d6f2431206f262e37">[email protected]</span></a> and to the EPA at:

<a href="/cdn-cgi/l/email-protection#dab4b9b3b99abfaabbb7bbb3b6f4bfaabbf4bdb5ac"><span class="__cf_email__" data-cfemail="701e131913301500111d11191c5e1500115e171f06">[email protected]</span></a>

    Electronic comments must be submitted as an ASCII file avoiding the 
use of special characters and any form of ecryption.
    The official record for the 37th report, as well as the public 
version as described above, will be kept in paper form. Accordingly, 
EPA will transfer all comments received electronically into printed, 
paper form as they are received and will place the paper copies in the 
official record which will also include all comments submitted directly 
in writing. The official record is the paper record maintained at the 
EPA address in ADDRESSES at the beginning of this document.

    Authority: 15 U.S.C. 2603.

Dated: January 22, 1996.
Charles M. Auer,
Director, Chemical Control Division, Office of Pollution Prevention and 
Toxics.

Thirty-Seventh Report of the TSCA Interagency Testing Committee to the 
Administrator, U.S. Environmental Protection Agency

Summary

    This is the 37th Report of the TSCA Interagency Testing Committee 
(ITC) to the Administrator of the U.S. Environmental Protection Agency 
(EPA). In this Report, the ITC is revising its TSCA section 4(e) 
Priority Testing List by recommending 28 alkylphenols and alkylphenol 
ethoxylates and removing 43 previously-recommended silicone chemicals 
and 5 isocyanates. As noted in this Report, the ITC is 

[[Page 4189]]
soliciting use and exposure data for 9 of the 12 High Production Volume 
Chemicals that were recommended in its 36th Report (60 FR 42982, August 
17, 1995) and consumer use and exposure data for the 10 isocyanates 
remaining on the List. Comments on this Report should be submitted both 
to the ITC and the TSCA Public Docket. The revised TSCA section 4(e) 
Priority Testing List follows as Table 1.

  Table 1.--The TSCA Section 4(e) Priority Testing List (November 1995) 
------------------------------------------------------------------------
   Report             Date             Chemical/Group        Action     
------------------------------------------------------------------------
26.........  May 1990..............  Isocyanates......  Recommended with
                                                         intent-to-     
                                                         designate.     
27.........  November 1990.........  62 Aldehydes.....  Recommended with
                                                         intent-to-     
                                                         designate.     
28.........  May 1991..............  Acetone..........  Designated.     
28.........  May 1991..............  Thiophenol.......  Designated.     
29.........  November 1991.........  10 Alkyl-, bromo-  Recommended.    
                                      , chloro-,                        
                                      hydroxymethyl                     
                                      diaryl ethers.                    
30.........  May 1992..............  13 Siloxanes.....  Recommended.    
31.........  January 1993..........  24 Chemicals with  Designated.     
                                      no dermal                         
                                      toxicity data.                    
32.........  May 1993..............  32 Chemicals with  Designated.     
                                      insufficient                      
                                      dermal                            
                                      absorption data.                  
34.........  May 1994..............  White phosphorus.  Designated.     
34.........  May 1994..............  Ethyl tert-butyl   Recommended.    
                                      ether.                            
34.........  May 1994..............  Tert-amyl methyl   Recommended.    
                                      ether.                            
35.........  November 1994.........  24 Chemicals with  Designated.     
                                      insufficient                      
                                      dermal                            
                                      absorption data.                  
36.........  May 1995..............  12 High            Recommended.    
                                      Production                        
                                      Volume Chemicals.                 
37.........  November 1995.........  28 Alkylphenols    Recommended.    
                                      and alkylphenol                   
                                      ethoxylates.                      
------------------------------------------------------------------------

I. Background

    The TSCA Interagency Testing Committee (ITC) was established by 
section 4(e) of the Toxic Substances Control Act (TSCA) ``to make 
recommendations to the Administrator respecting the chemical substances 
and mixtures to which the Administrator should give priority 
consideration for the promulgation of a rule for testing under section 
4(a).... At least every 6 months..., the Committee shall make such 
revisions in the List as it determines to be necessary and to transmit 
them to the Administrator together with the Committee's reasons for the 
revisions'' (Pub. L. 94-469, 90 Stat. 2003 et seq., 15 U.S.C. 2601 et 
seq.). Since its creation in 1976, the ITC has submitted 36 semi-annual 
Reports to the EPA Administrator transmitting the Priority Testing List 
and its revisions. These Reports have been published in the Federal 
Register and are also available from the ITC. The ITC meets monthly and 
produces its revisions of the List with the help of staff and technical 
contract support provided by EPA. ITC membership and support personnel 
are listed at the end of this Report.
    Following receipt of the ITC's Report and the addition of chemicals 
to the Priority Testing List, EPA's Office of Pollution Prevention and 
Toxics adds new chemicals from the List to TSCA section 8(a) and 8(d) 
rules that require manufacturers and importers of these chemicals to 
submit TSCA section 8(a) production and exposure data and 
manufacturers, importers and processors of the listed chemicals to 
submit TSCA section 8(d) health and safety studies within 60 days of 
the rule's effective date. The submissions are indexed and maintained 
by EPA. The ITC reviews the TSCA section 8(a) and 8(d) information and 
other available data on chemicals and chemical groups (e.g., TSCA 
section 8(e) ``substantial risk'' studies, ``For Your Information'' 
(FYI) submissions to EPA, and published papers) to determine if 
revisions to the List are necessary. Revisions can include changing a 
general recommendation to a specific designation for testing action by 
the EPA Administrator within 12 months, modifying the recommended 
testing, or removing the chemical or chemical group from the List.

II. Revisions to the TSCA Section 4(e) Priority Testing List

    Revisions to the TSCA section 4(e) Priority Testing List are 
summarized in Table 2.

   Table 2.--Revisions to the TSCA Section 4(e) Priority Testing List   
------------------------------------------------------------------------
    CAS No.         Chemical Name             Action             Date   
------------------------------------------------------------------------
                                                                        
                   Alkylphenols and    Recommended.........        11/95
                                                                        
                     Butylphenols      ....................             
                                                                        
88-18-6         2-tert-Butylphenol<SUP>a                                     
                                                                        
98-54-4         4-tert-Butylphenol<SUP>a..                                   
                                                                        
99-71-8         4-sec-Butylphenol<SUP>a...                                   
                                                                        
1638-22-8       4-n-Butylphenol<SUP>b.....                                   
                                                                        
3180-09-4       2-Butylphenol<SUP>b.......                                   
                                                                        
27178-34-3      tert-Butylphenol                                        
                 (mixed isomers)<SUP>b                                       
                                                                        
31195-95-6      Isobutylphenol (mixed                                   
                 isomers)<SUP>b                                              
                                                                        
                    Pentylphenols                                       
                                                                        
80-46-6         4-tert-Pentylphenol<SUP>a                                    
                                                                        
94-06-4         4-(1-                                                   
                 Methylbutyl)phenol<SUP>b                                    
                                                                        
14938-35-3      4-Pentylphenol<SUP>b                                         
                                                                        

[[Page 4190]]
                                                                        
                     Octylphenols                                       
                                                                        
949-13-3        2-Octylphenol<SUP>b                                          
                                                                        
1806-26-4       4-Octylphenol<SUP>b                                          
                                                                        
3884-95-5       2-(1,1,3,3-                                             
                 Tetramethylbutyl)phe                                   
                 nol<SUP>b                                                   
                                                                        
27193-28-8      (1,1,3,3-                                               
                 Tetramethylbutyl)phe                                   
                 nol (mixed                                             
                 isomers)<SUP>a,c                                            
                                                                        
1322-69-6                                                               
                                                                        
29932-96-5                                                              
                                                                        
30105-54-5                                                              
                                                                        
62744-41-6                                                              
                                                                        
27985-70-2      (1-                                                     
                 Methylheptyl)phenol                                    
                 (mixed isomers)<SUP>b                                       
                                                                        
54932-78-4      4-(2,2,3,3-                                             
                 Tetramethylbutyl)phe                                   
                 nol<SUP>b                                                   
                                                                        
                     Nonylphenols                                       
                                                                        
104-40-5        4-Nonylphenol<SUP>b                                          
                                                                        
11066-49-2      Isononylphenol (mixed                                   
                 isomers)<SUP>b                                              
                                                                        
17404-66-9      4-(1-                                                   
                 Methyloctyl)phenol<SUP>b                                    
                                                                        
25154-52-3      Nonylphenol (mixed                                      
                 isomers)<SUP>a,c                                            
                                                                        
1300-16-9                                                               
                                                                        
84852-15-3      Branched 4-                                             
                 nonylphenol (mixed                                     
                 isomers)<SUP>a                                              
                                                                        
                    Dodecylphenols                                      
                                                                        
104-43-8        4-Dodecylphenol<SUP>b                                        
                                                                        
27193-86-8      Dodecylphenol (mixed                                    
                 isomers)<SUP>a,c                                            
                                                                        
1331-57-3                                                               
                                                                        
                     Octylphenol                                        
                      ethoxylates                                       
                                                                        
2315-66-4       Decaethylene glycol 4-                                  
                 isooctylphenyl                                         
                 ether<SUP>b                                                 
                                                                        
2497-58-7       Hexaethylene glycol 4-                                  
                 isooctylphenyl                                         
                 ether<SUP>b                                                 
                                                                        
9002-93-1       Polyethylene glycol 4-                                  
                 (tert-octyl)phenyl                                     
                 ether<SUP>b                                                 
                                                                        
9036-19-5       Polyethylene glycol                                     
                 mono(octyl)phenyl                                      
                 ether<SUP>b                                                 
                                                                        
68987-90-6      Poly(oxy-1,2-                                           
                 ethanediyl),<greek-a                                   
                 >-(octylphenyl)-                                       
                 <greek-oh>-hydroxy-,                                   
                 branched<SUP>a                                              
                                                                        
                  Silicone Chemicals   Remove previously           11/95
                                        recommended                     
                                        chemicals                       
                                                                        
107-50-6        Tetradecamethylcylohe                                   
                 ptasiloxane                                            
                                                                        
107-52-8        Tetradecamethylhexasi                                   
                 loxane                                                 
                                                                        
107-53-9        Tetracosamethylundeca                                   
                 siloxane                                               
                                                                        
541-01-5        Hexadecamethylheptasi                                   
                 loxane                                                 
                                                                        
541-05-9        Hexamethylcyclotrisil                                   
                 oxane                                                  
                                                                        
546-56-5        Octaphenylcyclotetras                                   
                 iloxane                                                
                                                                        
556-68-3        Hexadecamethylcyclooc                                   
                 tasiloxane                                             
                                                                        
556-69-4        Octadecamethyloctasil                                   
                 oxane                                                  
                                                                        
556-70-7        Docosamethyldecasilox                                   
                 ane                                                    
                                                                        
556-71-8        Octadecamethylcyclono                                   
                 nasiloxane                                             
                                                                        
999-97-3        Hexamethyldisilazane                                    
                                                                        
2370-88-9       Tetramethylcyclotetra                                   
                 siloxane                                               
                                                                        
2374-14-3       Trifluoropropylmethyl                                   
                 cyclotrisiloxane                                       
                                                                        
2471-08-1       Hexacosamethyldodecas                                   
                 iloxane                                                
                                                                        
2471-09-2       Octacosamethyltrideca                                   
                 siloxane                                               
                                                                        
2471-10-5       Triacontamethyltetrad                                   
                 ecasiloxane                                            
                                                                        
2471-11-6       Dotriacontmethylpenta                                   
                 decasiloxane                                           
                                                                        
2554-06-5       Methylvinylcyclosilox                                   
                 ane                                                    
                                                                        
2627-95-4       Tetramethyldivinyldis                                   
                 iloxane                                                
                                                                        
2652-13-3       Eicosamethylnonasilox                                   
                 ane                                                    
                                                                        

[[Page 4191]]
                                                                        
9004-73-3       Methylpolysiloxane                                      
                                                                        
9006-65-9       Dimethicone                                             
                                                                        
9016-00-6       Polydimethylsiloxane                                    
                                                                        
18766-38-6      Docosamethylcyclounde                                   
                 casiloxane                                             
                                                                        
18772-36-6      Eicosamethylcyclodeca                                   
                 siloxane                                               
                                                                        
18844-04-7      Hexatriacontamethylhe                                   
                 ptadecasiloxane                                        
                                                                        
18919-94-3      Tetracosamethylcyclod                                   
                 odecasiloxane                                          
                                                                        
23523-12-8      Hexatriacontamethylcy                                   
                 clooctadecasiloxane                                    
                                                                        
23523-14-0      Triacontamethylcyclop                                   
                 entadecasiloxane                                       
                                                                        
23732-94-7      Hexacosamethylcyclotr                                   
                 idecasiloxane                                          
                                                                        
36938-50-8      Tetratriacontamethylh                                   
                 exadecasiloxane                                        
                                                                        
36938-52-0      Octatriacontamethyloc                                   
                 tadecasiloxane                                         
                                                                        
67762-94-1      Dimethylmethylvinylsi                                   
                 loxane                                                 
                                                                        
68037-59-2      Dimethylhydropolysilo                                   
                 xane                                                   
                                                                        
68607-75-0      Polymethyloctadecylsi                                   
                 loxane                                                 
                                                                        
115631-68-7     Siloxanes and                                           
                 silicones,                                             
                 dimethylmethyl 3,3,3-                                  
                 trifluoropropyl<SUP>d                                       
                                                                        
149050-40-8     Octacosamethylcyclote                                   
                 tradecasiloxane                                        
                                                                        
150026-95-2     Dotriacontamethylcycl                                   
                 ohexadecasiloxane                                      
                                                                        
150026-96-3     Tetratriacontamethylc                                   
                 ycloheptadecasiloxan                                   
                 e                                                      
                                                                        
150026-97-4     Octatriacontamethylcy                                   
                 clononadecasiloxane                                    
                                                                        
150026-98-5     Tetracontamethylcyclo                                   
                 eicosasiloxane                                         
                                                                        
150026-99-6     Tetracontamethylnonad                                   
                 ecasiloxane                                            
                                                                        
150027-00-2     Dotetracontamethyleic                                   
                 osasiloxane                                            
                                                                        
                     Isocyanates       Remove previously           11/95
                                        recommended                     
                                        chemicals                       
                                                                        
102-36-3        3,4-Dichlorophenyl                                      
                 isocyanate                                             
                                                                        
104-71-9        Phenyl isocyanate                                       
                                                                        
104-12-1        p-Chlorophenyl                                          
                 isocyanate                                             
                                                                        
111-36-4        n-Butyl isocyanate                                      
                                                                        
3173-53-3       Cyclohexyl isocyanate                                   
                                                                        
------------------------------------------------------------------------
<SUP>a Chemicals with production or importation volumes > 1 million pounds   
  that are being considered for designation.                            
<SUP>b Chemicals with production or importation volumes < 1 million pounds   
  that are being recommended because they are structurally related to   
  alkylphenols or alkylphenol ethoxylates being considered for          
  designation.                                                          
<SUP>c Alternate CAS numbers are listed for these chemicals.                 
<SUP>d Listed as dimethylmethyltrifluoropropylsiloxane with no CAS number in 
  ITC's 30th Report (57 FR 30608, July 9, 1992).                        



III. Rationale for the Revisions

A. ITC's Activities During this Reporting Period

    During the 6 months covered by this Report, the ITC evaluated 
several chemical groups. For alkylphenols and alkylphenol ethoxylates, 
1989 and 1993 TSCA production and importation volume data were reviewed 
and online toxicology databases were searched. For silicone chemicals, 
unpublished chemistry, toxicology, use and exposure data were reviewed; 
these data were submitted in response to the ITC's 30th Report (57 FR 
30608, July 9, 1992). For the isocyanates recommended in the ITC's 26th 
Report (55 FR 23050, June 5, 1990), published and unpublished 
toxicology, use and exposure data were reviewed.

B. Specific Rationales

    1. Recommended chemicals-- Alkylphenols and alkylphenol 
ethoxylates--Recommendation. Alkylphenols and alkylphenol ethoxylates 
are being added to the Priority Testing List to obtain unpublished TSCA 
section 8(d) studies and to determine if these studies meet U.S. 
Government data needs.
    Rationale for recommendation. Alkylphenols and alkylphenol 
ethoxylates are being recommended to determine if there are unpublished 
studies that contain data to meet the needs of the Department of the 
Interior (DoI), the EPA and other U.S. Government organizations 
represented on the ITC. The ITC wants to review these unpublished data 
before determining if these chemicals should be designated for testing 
to meet U.S. Government data needs. Alkylphenols and alkylphenol 
ethoxylates are being recommended at this time because: (1) 1989 and 
1993 TSCA production and importation volumes are in the multimillion 
pound range, (2) releases to the environment can occur through 
wastewater treatment systems and from agricultural runoff, (3) 
alkylphenol ethoxylates can degrade to alkylphenols, (4) alkylphenols 
can persist in the environment and be highly toxic to aquatic organisms 
and (5) exposure to 

[[Page 4192]]
alkylphenols and alkylphenol ethoxylates may result in estrogenic, 
reproductive or other adverse effects.
    Supporting information. The Substructure-based Computerized 
Chemical Selection Expert System (SuCCSES) is used to identify 
chemicals with shared substructures and associated health or ecological 
effects and similar TSCA production or importation volumes (Walker, 
Refs. 4 and 6). SuCCSES was used to identify the alkylphenols and 
alkylphenol ethoxylates listed in Table 2. As indicated in Table 2, 
nine of the alkylphenols and alkylphenol ethoxylates have 1989 and 1993 
TSCA production and importation volumes greater than 1 million pounds 
and are being considered for designation. The ITC is listing alternate 
CAS numbers for some of these alkylphenols and alkylphenol ethoxylates 
to increase the possibility of retrieving a study because it is filed 
under a different CAS number. Table 2 also indicates that 19 
alkylphenols and alkylphenol ethoxylates are being recommended because 
they are structurally related to those being considered for 
designation. Relevant data from these additional 19 chemicals will be 
used to predict or gain insight into the activity of the 9 alkylphenols 
and alkylphenol ethoxylates being considered for designation when no 
data are available for those 9 chemicals. The ITC is recommending 
structurally-related chemicals and alternate CAS-numbered chemicals to 
increase the possibility of obtaining unpublished studies on 
alkylphenols and alkylphenol ethoxylates that are related to those 
being considered for designation.
    Existing U.S. Government data needs. The ITC has identified several 
data needs for alkylphenols and alkylphenol ethoxylates: (1) chemical 
composition (major components and impurities), (2) environmental fate 
of components and impurities and (3) health and ecological effects, 
including toxicokinetics and endocrine-modulating effects.
    Completed activities of the ITC, EPA and alkylphenol manufacturers. 
The ITC is aware that for a few alkylphenols and alkylphenol 
ethoxylates there are numerous studies including those already 
developed under TSCA section 4 (Talmage, Ref. 3). The ITC is also aware 
that for some of these chemicals, few health effects, environmental 
fate and ecological effects data are available. The ITC reviews of 
butylphenols, pentylphenols, octylphenols, and nonylphenols suggested 
that these chemicals had potential to cause biological effects. Studies 
by Soto et al. (Ref. 2), White et al. (Ref. 10) and Purdom et al. (Ref. 
1) suggest that alkylphenols and alkylphenol ethoxylates may cause 
endocrine-modulating effects. Soto et al. (Ref. 2) reported that 
nonylphenol and 4-tert-butylphenol caused proliferation of human 
estrogen-sensitive MCF<INF>7 breast tumor cells. White et al. (Ref. 10) 
reported that 4-octylphenol, 4-nonylphenol and 4-nonylphenol 
diethoxylate were capable of stimulating vitellogenin gene expression 
in trout hepatocytes. Vitellogenin is a protein synthesized by the 
liver of oviparous fish in response to stimulation by estradiol or 
estrogenic compounds. Purdom et al. (Ref. 1) suggested that 
alkylphenols or alkylphenol ethoxylates may have been responsible for 
elevated vitellogenin concentrations in fish exposed to effluents from 
15 sewage-treatment works.
    The ITC previously designated three alkylphenols for testing. 2-
sec-Butylphenol was designated in the 32nd Report (58 FR 38490, July 
16, 1993). In response to this designation, the EPA solicited parties 
that would be interested in developing consent agreements for dermal 
absorption testing. The ITC designated 4-(1,1,3,3-
tetramethylbutyl)phenol in its 11th Report (47 FR 54625, December 3, 
1982) and 2,6-di-tert-butylphenol in its 18th Report (51 FR 18368, May 
19, 1986). In response to these designations, the EPA implemented 
testing and the alkylphenol manufacturers developed the TSCA section 4 
chemical fate and aquatic toxicity data. These data have been published 
(Walker, Refs. 5, 7, and 8).
    The EPA has pursued testing for two other alkylphenols. The EPA 
published a TSCA section 4 notice proposing reproductive effects and 
developmental toxicity testing for dodecylphenol (56 FR 9092, March 4, 
1991). The EPA worked with the alkylphenol manufacturers to develop 
chemical fate and aquatic toxicity data for branched 4-nonylphenol 
under a TSCA section 4 Enforceable Consent Agreement/Order (55 FR 5991, 
February 21, 1990). These data for branched 4-nonylphenol have been 
published (Walker, Ref. 8).
    The TSCA section 8(d) rule that EPA promulgated for 2-sec-
butylphenol did not require submission of ecological effects data (59 
FR 5956, February 9, 1994). The ITC is recommending that the EPA amend 
this rule to require submission of ecological effects data in response 
to the data needs of the DoI and EPA. In response to the ITC's 
designations of 4-(1,1,3,3-tetramethylbutyl)phenol and 2,6-di-tert-
butylphenol, the EPA promulgated TSCA section 8(d) rules. The ITC will 
include studies that were submitted in response to these rules in its 
review of other unpublished studies that are submitted in response to 
the TSCA section 8(d) rules that the EPA will promulgate for the other 
alkylphenols or alkylphenol ethoxylates listed in Table 2. The ITC is 
not recommending these three alkylphenols because TSCA section 8(d) 
studies were previously submitted in response to these designations.
    Related activities. The Organisation for Economic Cooperation and 
Development (OECD) has three of the recommended and two of the 
previously-designated alkylphenols in its Screening Information Data 
Sets (SIDS) program. The recommended alkylphenols with their sponsoring 
countries listed in parentheses are 4-tert-butylphenol (Japan), 
nonylphenol (mixed isomers) (United Kingdom and United States) and 
branched 4-nonylphenols (mixed isomers) (United Kingdom). The 
previously-designated alkylphenols are 4-(1,1,3,3-
tetramethylbutyl)phenol and 2,6-di-tert-butylphenol (both the United 
States). The National Toxicology Program has scheduled branched 4-
nonylphenols (mixed isomers) for a multigeneration reproductive effects 
and developmental toxicity test. The National Academy of Sciences is 
planning to review published data on hormone-related chemicals in the 
environment and alkylphenols is one chemical group for which they will 
be reviewing data. Industry convened the Endocrine Issues Coalition in 
1995 to address scientific issues related to subtances in the 
environment that potentially may modulate the endocrine system. The 
CMA's Alkylphenols and Ethoxylates Panel is a member of this Coalition.
    2. Removal of chemicals from the Priority Testing List--a. Silicone 
chemicals. Fifty-six silicone chemicals were recommended for health 
effects testing in the ITC's 30th Report to meet the data needs of the 
Food and Drug Administration (57 FR 30608, July 9, 1992). In response 
to this recommendation, the Silicones Environmental Health and Safety 
Council (SEHSC) met with the ITC and the EPA to discuss unpublished 
toxicity, use and exposure data. Most of the unpublished toxicity and 
exposure data were submitted in response to the TSCA section 8(d) 
reporting rule that was promulgated in response to the ITC's 30th 
Report recommendations (58 FR 28511, May 15, 1993) and the technical 
amendments to that rule (58 FR 47647, September 10, 1993). All of the 
use data and some of the exposure data were submitted voluntarily to 
the 

[[Page 4193]]
ITC by the SEHSC. Interactions with the SEHSC facilitated information 
exchange and data development for a previously-designated siloxane, 
octamethylcyclotetrasiloxane (Walker and Smock, Ref. 9). The SEHSC 
worked with the ITC and the EPA to develop a computerized system of 
physical properties, effects and use data for the 56 recommended 
silicone chemicals. The ITC has used the information in this system, 
the TSCA section 8(a) production and exposure data, and the information 
submitted voluntarily by the SEHSC to determine that, at this time, 43 
of the previously-recommended silicone chemicals should be removed from 
the Priority Testing List (Table 2). The specific rationales for 
removing these chemicals are listed in the following Table 3.

 Table 3.--Previously Recommended Silicone Chemicals Being Removed From 
                        the Priority Testing List                       
------------------------------------------------------------------------
    CAS No.             Chemical Name             Removal rationale     
------------------------------------------------------------------------
                                                                        
999-97-3         Hexamethyldisilazane                                   
                                                                        
9006-65-9        Dimethicone                 Highly reactive with       
                                              moisture and therefore    
                                              difficult to test for     
                                              health effects            
                                                                        
9016-00-6        Polydimethylsiloxane        Highly reactive with       
                                              moisture and therefore    
                                              difficult to test for     
                                              health effects            
                                                                        
9004-73-3        Methylpolysiloxane                                     
                                                                        
115631-68-7      Siloxanes and silicones,    Synonyms for dimethyl      
                  dimethylmethyl 3,3,3-       silicones and siloxanes   
                  trifluoropropyl<SUP>a            that remains on the       
                                              Priority Testing List     
                                                                        
67762-94-1       Dimethylmethylvinylsiloxan  Site-limited intermediates 
                  e                           used in the production of 
                                              siloxane polymers         
                                                                        
68037-59-2       Dimethylhydropolysiloxane   Site-limited intermediates 
                                              used in the production of 
                                              siloxane polymers         
                                                                        
68607-75-0       Polymethyloctadecylsiloxan  Siloxane polymers that are 
                  e                           consumed in their end use 
                                                                        
546-56-5         Octaphenylcyclotetrasiloxa  Siloxane that has no       
                  ne                          commercial sales or       
                                              applications at this time 
                                                                        
2370-88-9        Tetramethylcyclotetrasilox  Siloxane that has no       
                  ane                         commercial sales or       
                                              applications at this time 
                                                                        
2374-14-3        Trifluoropropylmethylcyclo  Siloxane that has no       
                  trisiloxane                 commercial sales or       
                                              applications at this time 
                                                                        
2554-06-5        Methylvinylcyclosiloxane    Siloxane that has no       
                                              commercial sales or       
                                              applications at this time 
                                                                        
2627-95-4        Tetramethyldivinyldisiloxa  Siloxane that has no       
                  ne                          commercial sales or       
                                              applications at this time 
                                                                        
                      Linear Siloxanes                                  
                                                                        
107-52-8         Tetradecamethylhexasiloxan  Siloxanes that are limited 
                  e (L<INF>6)<SUP>b                     to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
541-01-5         Hexadecamethylheptasiloxan  Siloxanes that are limited 
                  e (L<INF>7)                      to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
556-69-4         Octadecamethyloctasiloxane  Siloxanes that are limited 
                  (L<INF>8)                        to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
2652-13-3        Eicosamethylnonasiloxane    Siloxanes that are limited 
                  (L<INF>9)                        to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
556-70-7         Docosamethyldecasiloxane    Siloxanes that are limited 
                  (L<INF>10)                       to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
107-53-9         Tetracosamethylundecasilox  Siloxanes that are limited 
                  ane (L<INF>11)                   to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
2471-08-1        Hexacosamethyldodecasiloxa  Siloxanes that are limited 
                  ne (L<INF>12)                    to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
2471-09-2        Octacosamethyltridecasilox  Siloxanes that are limited 
                  ane (L<INF>13)                   to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
2471-10-5        Triacontamethyltetradecasi  Siloxanes that are limited 
                  loxane (L<INF>14)                to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
2471-11-6        Dotriacontmethylpentadecas  Siloxanes that are limited 
                  iloxane (L<INF>15)               to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
36938-50-8       Tetratriacontamethylhexade  Siloxanes that are limited 
                  casiloxane (L<INF>16)            to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
18844-04-7       Hexatriacontamethylheptade  Siloxanes that are limited 
                  casiloxane (L<INF>17)            to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
36938-52-0       Octatriacontamethyloctadec  Siloxanes that are limited 
                  asiloxane (L<INF>18)             to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150026-99-6      Tetracontamethylnonadecasi  Siloxanes that are limited 
                  loxane (L<INF>19)                to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150027-00-2      Dotetracontamethyleicosasi                             
                  loxane (L<INF>20)                                          
                                                                        
                      Cyclic Siloxanes                                  
                                                                        
541-05-9         Hexamethylcyclotrisiloxane  Siloxanes that are limited 
                  (D<INF>3)<SUP>c                       to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
107-50-6         Tetradecamethylcyloheptasi  Siloxanes that are limited 
                  loxane (D<INF>7)                 to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        

[[Page 4194]]
                                                                        
556-68-3         Hexadecamethylcyclooctasil  Siloxanes that are limited 
                  oxane (D<INF>8)                  to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
556-71-8         Octadecamethylcyclononasil  Siloxanes that are limited 
                  oxane (D<INF>9)                  to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
18772-36-6       Eicosamethylcyclodecasilox  Siloxanes that are limited 
                  ane (D<INF>10)                   to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
18766-38-6       Docosamethylcycloundecasil  Siloxanes that are limited 
                  oxane (D<INF>11)                 to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
18919-94-3       Tetracosamethylcyclododeca  Siloxanes that are limited 
                  siloxane (D<INF>12)              to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
23732-94-7       Hexacosamethylcyclotrideca  Siloxanes that are limited 
                  siloxane (D<INF>13)              to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
149050-40-8      Octacosamethylcyclotetrade  Siloxanes that are limited 
                  casiloxane (D<INF>14)            to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
23523-14-0       Triacontamethylcyclopentad  Siloxanes that are limited 
                  ecasiloxane (D<INF>15)           to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150026-95-2      Dotriacontamethylcyclohexa  Siloxanes that are limited 
                  decasiloxane (D<INF>16)          to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150026-96-3      Tetratriacontamethylcycloh  Siloxanes that are limited 
                  eptadecasiloxane (D<INF>17)      to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
23523-12-8       Hexatriacontamethylcyclooc  Siloxanes that are limited 
                  tadecasiloxane (D<INF>18)        to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150026-97-4      Octatriacontamethylcyclono  Siloxanes that are limited 
                  nadecasiloxane (D<INF>19)        to industrial applications
                                              and transformed to        
                                              polymers during processing
                                                                        
150026-98-5      Tetracontamethylcycloeicos  Siloxanes that are non-    
                  asiloxane (D<INF>20)             isolated components of    
                                              dimethyl siloxanes        
------------------------------------------------------------------------
<SUP>a Listed as dimethylmethyltrifluoropropylsiloxane with no CAS number in 
  ITC's 30th Report (57 FR 30608, July 9, 1992).                        
<SUP>b L followed by a number refers to the number of repeating dimethyl     
  siloxanes in a linear chain.                                          
<SUP>c D followed by a number refers to the number of repeating dimethyl     
  siloxanes in a cyclic chain.                                          


    There are 13 siloxanes remaining on the Priority Testing List as 
shown in the following Table 4:

       Table 4.--Siloxanes remaining on the Priority Testing List       
------------------------------------------------------------------------
     CAS No.                           Chemical Name                    
------------------------------------------------------------------------
                                                                        
                                      Cyclic Siloxanes                  
                                                                        
556-67-2           Octamethylcyclotetrasiloxane (D<INF>4)                    
                                                                        
541-02-6           Decamethylcyclopentasiloxane (D<INF>5)                    
                                                                        
540-97-6           Dodecamethylcyclohexasiloxane (D<INF>6)                   
                                                                        
69430-24-6         Cyclopolydimethylsiloxane (D<INF>x)                       
                                                                        
                                      Linear Siloxanes                  
                                                                        
107-46-0           Hexamethyldisiloxane (L<INF>2)                            
                                                                        
107-51-7           Octamethyltrisiloxane (L<INF>3)                           
                                                                        
141-62-8           Decamethyltetrasiloxane (L<INF>4)                         
                                                                        
141-63-9           Dodecamethylpentasiloxane (L<INF>5)                       
                                                                        
                                      Phenyl Siloxanes                  
                                                                        
68083-14-7         Dimethyldiphenylsiloxane<SUP>a                            
                                                                        
                                          Polymers                      
                                                                        
63148-62-9         Dimethyl silicones and siloxanes<SUP>a                    
                                                                        
9006-65-9                                                               
                                                                        
9016-00-6                                                               
                                                                        
67762-90-7         Dimethyl silicones and siloxanes, reaction products  
                    with silica                                         
                                                                        
68037-74-1         Dimethylmonomethylpolysiloxanes                      
                                                                        

[[Page 4195]]
                                                                        
70131-67-8         Dimethyl silicones and siloxanes hydroxy terminated  
------------------------------------------------------------------------
<SUP>aAlternate CAS numbers are listed for this chemical.                    


    b. Isocyanates.
    In its 26th Report, the ITC recommended a group of 43 isocyanates 
for physical and chemical property testing in response to a nomination 
from the EPA to support its TSCA New Chemicals Program (55 FR 23050, 
June 5, 1990). The ITC removed 28 of these isocyanates from the 
Priority Testing List in its 35th Report 59 FR 67596, December 29, 
1994). The ITC is removing 5 more isocyanates from the List in this 
Report (Table 2). 3,4-Dichlorophenyl isocyanate and p-chlorophenyl 
isocyanate are being removed because 1993 production volumes were less 
than 10,000 pounds. Phenyl isocyanate is being removed because 1993 
production volumes were less than 1,000,000 pounds and there are no 
currently identified U.S. Government data needs. n-Butyl isocyanate and 
cyclohexyl isocyanate are being removed because there are no currently 
identified U.S. Government data needs.

IV. Activities Related to Previously-Recommended Chemicals

A. High Production Volume Chemicals

    The ITC solicited use and exposure data for 12 High Production 
Volume Chemicals (HPVCs) in its 36th report (60 FR 42982, August 17, 
1995) and suggested a 60-day submission deadline from the FR 
publication date (October 17, 1995). In response to that solicitation, 
the ITC received a September 15, 1995, submission from Eastman Chemical 
Company for diethylene glycol monoethyl ether acetate (CAS No. 112-15-
2), a September 19, 1995, offer from the Zeneca Corporation to provide 
use and exposure data for trichloromethane sulfenyl chloride (CAS No. 
594-42-3) and an October 12, 1995, submission from Ferro Corporation 
for diethylene glycol dimethyl ether (CAS No. 111-96-6). The ITC will 
review the use and exposure data for these three HPVCs. The ITC 
appreciates these timely responses and encourages the manufacturers, 
processors, and users of the other nine HPVCs to contact the ITC with 
offers to provide use and exposure data.

B. Isocyanates

    The ITC is soliciting consumer use data for the nine diisocyanates 
remaining on the Priority Testing List (Table 5). The data are being 
solicited to address the information needs of the Consumer Product 
Safety Commission (CPSC). For several of these isocyanates, the ITC is 
continuing its review of exposure, health effects and chemical fate 
information, including information based on structure-activity 
relationships (SARs), in response to concerns of the Department of 
Defense (DoD) and the EPA.
    In its 26th Report, the ITC recommended a group of 43 isocyanates 
for physical and chemical property testing in response to a nomination 
from the EPA to support its TSCA New Chemicals Program (55 FR 23050, 
June 5, 1990). As noted above in section III(B)(2)(b) of this ITC 
Report, 33 of these isocyanates have been removed from the Priority 
Testing List. The 10 remaining isocyanates are listed in the following 
Table 5.

      Table 5.--Isocyanates Remaining on the Priority Testing List      
------------------------------------------------------------------------
    CAS No.                           Chemical Name                     
------------------------------------------------------------------------
                                                                        
                                     Monoisocyanate                     
                                                                        
329-01-1        (<greek-a>,<greek-a>,<greek-a>-Trifluoro-m-             
                 tolyl)isocyanate                                       
                                                                        
                                      Diisocyanates                     
                                                                        
91-08-7         2,6-Toluene diisocyanate (2,6-TDI)                      
                                                                        
101-68-8        4,4'-Diphenylmethane diisocyanate (MDI)                 
                                                                        
584-84-9        2,4-Toluene diisocyanate (2,4-TDI)                      
                                                                        
4035-89-6       Tris(isocyanatohexyl)biuret                             
                                                                        
4098-71-9       Isophorone diisocyanate                                 
                                                                        
5124-30-1       1,1'-Methylenebis(4-isocyanatocyclohexane)              
                                                                        
5873-54-1       1-Isocyanato-2-((4-isocyanatophenyl)methyl)benzene      
                                                                        
26447-40-5      1,1'-Methylenebis(isocyanatobenzene)                    
                                                                        
26471-62-5      Toluene diisocyanate (80% 2,4-TDI; 20% 2,6-TDI)         
------------------------------------------------------------------------

    For these 10 isocyanates, the ITC is reviewing data on 1993 TSCA 
production and importation volumes, as well as published and 
unpublished (TSCA section 8(d), 8(e), FYI, etc.) data on physical and 
chemical properties, environmental fate and releases, health effects, 
occupational exposures and uses. For each of these isocyanates, the ITC 
is monitoring ongoing testing, including any testing that might be 
considered by the International Isocyanates Institute, the CMA or the 
OECD.
    At this time, the ITC has determined that there are insufficient 
consumer use and exposure data to permit an accurate assessment of 
exposure or the need for additional testing of the diisocyanates listed 
in Table 5. The ITC is soliciting consumer use data on these as well as 


[[Page 4196]]
any other commercially relevant diisocyanates (e.g., hexamethylene 
diisocyanate, CAS No. 822-06-0). Information on the presence of 
diisocyanates in commercially available products is needed as well as 
information on exposures that result from their use. The following 
specific information is solicited:
    \ Category of products in which diisocyanates (all forms) are 
present, such as rigid and flexible foams, coatings, and adhesives
    \ Specific diisocyanate present, by product category
    \ Chemical form of the diisocyanate (monomer, prepolymer, oligomer, 
polymer, etc.)
    \ Weight fraction of diisocyanate in the product and the relative 
amount of the different diisocyanate forms, particularly free monomer, 
oligomer, and prepolymer (a rough range of weight fraction is 
sufficient)
    \ Percent of total manufactured/imported volume (rough estimate is 
sufficient)
    \ Form of the product (liquid, aerosol, foam, etc.)
    \ General application of the product (sealant, paint, adhesive, 
insulation, etc.)
    \ Air monitoring or exposure simulation data for diisocyanates 
resulting from use of any of the indicated product categories

References

    (1) Purdom, C.E., Hardiman, P.A., Bye, V.J., Eno, N.C., Tyler, 
C.R., and Sumpter, J.P. Estrogenic effects of effluents from sewage 
treatments works. Chemical Ecology. 8:275-285 (1994).
    (2) Soto, A.M., Justicia, H., Wray, J.W., and Sonnenschein, C. 
p-Nonylphenol: an estrogenic xenobiotic released from ``modified'' 
polystyrene. Environmental Health Perspectives. 92:167-173 (1991).
    (3) Talmage, S.S. Environmental and human safety of major 
surfactants: Alcohol ethoxylates and alkylphenol ethoxylates. A 
report to the Soap and Detergent Association. Lewis Publishers, Boca 
Raton, FL (1994), 374pp.
    (4) Walker, J.D. Chemical selection by the TSCA Interagency 
Testing Committee: Use of computerized substructure searching to 
identify chemical groups for health effects, chemical fate and 
ecological effects testing. Sci. Total Environ. 109/110:691-700 
(1991).
    (5) Walker, J.D. Review of ecological effects and 
bioconcentration testing recommended by the TSCA Interagency Testing 
Committee and implemented by EPA under the Toxic Substances Control 
Act: Chemicals, tests and methods. pp. 92-115. In W.G. Landis, J.S. 
Hughes and M.A. Lewis (eds.), Environmental Toxicology and Risk 
Assessment, ASTM STP 1179. ASTM, Philadelphia, PA (1993).
    (6) Walker, J.D. Estimation Methods Used by the TSCA Interagency 
Testing Committee to Prioritize Chemicals for Testing: Exposure and 
Biological Effects Scoring and Structure Activity Relationships. 
Toxicol. Model. 1:123-141 (1995a).
    (7) Walker, J.D. Testing Decisions of the TSCA Interagency 
Testing Committee for Chemicals on Canada's Domestic Substances List 
and Priority Substances List: Di-tert-butylphenol, ethyl benzene, 
brominated flame retardants, phthalate esters, chloroparaffins, 
chlorinated benzenes and anilines. In T.W. LaPoint, F.T. Price, and 
E.E. Little (eds), Environmental Toxicology and Risk Assessment: 
Fourth Volume, ASTM STP 1262, ASTM, Philadelphia. In Press (1995b).
    (8) Walker, J.D. Recommendations of the TSCA Interagency Testing 
Committee: Aquatic toxicity, bioconcentration and chemical fate data 
developed under section 4 of the Toxic Substances Control Act. pp. 
669-701. In G.M. Rand (ed), Fundamentals of Aquatic Toxicology II, 
Taylor Francis Publishers, Washington, DC (1995c).
    (9) Walker, J.D. and W.H. Smock. Chemicals recommended for 
testing by the TSCA Interagency Testing Committee: A case study of 
octamethylcyclotetrasiloxane. Environmental Toxicology and Chemistry 
14:1631-1634 (1995).
    (10) White, R., Jobling, S., Hoare, S.A., Sumpter, J.P., and 
Parker, M.G. Environmentally persistent alkylphenol compounds are 
estrogenic. Endocrinology 135:175-182 (1994).

TSCA Interagency Testing Committee

Statutory Organizations and Their Representatives

    Council on Environmental Quality
        Brad Campbell, Member

     Department of Commerce
        Edward White, Member

     Environmental Protection Agency
        David R. Williams, Member
        Lois Dicker, Alternate

    National Cancer Institute
        Victor Fung, Member
        Harry Seifried, Alternate

    National Institute of Environmental Health Sciences
        Errol Zeiger, Member, Chair
        H. B. Matthews, Alternate

    National Institute for Occupational Safety and Health
        Henryka Nagy, Member
        David A. Dankovic, Alternate

    National Science Foundation
        Linda Duguay, Member

    Occupational Safety and Health Administration
        Lyn Penniman, Member
        Christine Whittaker, Alternate

    Liaison Organizations and Their Representatives
    Agency for Toxic Substances and Disease Registry
        William Cibulas, Member

    Consumer Product Safety Commission
        Val Schaeffer, Member
        Lakshmi C. Mishra, Alternate

    Department of Agriculture
        Clifford Rice, Member

    Department of Defense
        David A. Macys, Member

    Department of the Interior
        Barnett A. Rattner, Member, Vice Chair

    Food and Drug Administration
        Edwin J. Matthews, Member
        Raju Kammula, Alternate

    National Library of Medicine
        Vera Hudson, Member

    National Toxicology Program
        NIEHS, FDA and NIOSH Members

    Counsel
        Mary Ellen Levine, Office of General Counsel, EPA

    Technical Support Contractor
        Syracuse Research Corporation

    ITC Staff
        John D. Walker, Ph.D, M.P.H., Executive Director
        Norma S.L. Williams, Executive Assistant,
        TSCA Interagency Testing Committee, U.S. EPA/OPPT (MC/7401), 
401 M St., SW., Washington, DC 20460, Phone: (202) 260-1825, Fax: 
(202) 260-7895 Internet:

<a href="/cdn-cgi/l/email-protection#80f7e1ecebe5f2aeeaefe8eee4c0e5f0e1ede1e9ecaee5f0e1aee7eff6"><span class="__cf_email__" data-cfemail="186f7974737d6a36727770767c587d687975797174367d6879367f776e">[email protected]</span></a>
[FR Doc. 96-1721 Filed 2-1-96; 8:45 am]
BILLING CODE 6560-50-F

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