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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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FORM 10-K



| | x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
| | - | ------------------------------------------------------------------------------------



For the fiscal year ended December 31, 2005



OR



| |  ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
| | - | ----------------------------------------------------------------------------------------



For the transition period from
 to



Commission File No. 000-27409



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AKESIS PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)



|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Nevada                                                         |  | 84-1409219                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)
|                                                               | 
|888 Prospect Street Suite 320 La Jolla, California             |  | 92037                               
|(Address of principal executive offices)                       |  | (Zip Code)                          



(858) 454-4311

(Registrants telephone number, including area code)



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Securities registered pursuant to Section 12(b) of the Act: None



Securities registered pursuant to Section 12(g) of the Act: Common Stock ($0.001 Par Value)



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Indicate by check mark if the registrant is a
well-known seasoned issuer as defined in Rule 405 of the Securities Act of 1933.    Yes ̈No x



Indicate by check mark if the
registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act of 1934.    Yes ̈No x



Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter
period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes x    No ̈



Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained to the best of registrants knowledge, in definitive proxy
or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. ̈



Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, or a non-accelerated filer (as defined in Rule 12b-2 of the Securities Exchange Act of 1934).



Large accelerated filer ̈Accelerated filer ̈Non-accelerated filer  x



Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Securities Exchange Act of
1934).    Yes ̈No x



The aggregate market value of the common stock held by non-affiliates of the
registrant as of June 30, 2005 was approximately $50.1 million. For purposes of this calculation, all executive officers and directors of the registrant and all beneficial owners of more than ten percent or more of the registrants common
stock were considered affiliates.



As of March 1, 2006,
the registrant had outstanding 15,272,552 shares of common stock.



DOCUMENTS INCORPORATED BY REFERENCE



Portions
of the registrants Proxy Statement for the 2006 Annual Meeting of Stockholders are incorporated by reference in Part III of this Form 10-K.



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AKESIS PHARMACEUTICAL, INC.



FORM 10-K



Year Ended December 31, 2005



INDEX



|           |  |                                                                                                              |  |     
|---------- |  | ------------------------------------------------------------------------------------------------------------ |  | ----
|           |  |                                                                                                              |  | Page
|PART I     |  | 1                                                                                                           
|Item 1.    |  | Business                                                                                                     |  | 1   
|Item 1A.   |  | Risk Factors                                                                                                 |  | 14  
|Item 2.    |  | Properties                                                                                                   |  | 23  
|Item 3.    |  | Legal Proceedings                                                                                            |  | 23  
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                                          |  | 23  
|           | 
|PART II    |  | 24                                                                                                          
|Item 5.    |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  | 24  
|Item 6.    |  | Selected Financial Data                                                                                      |  | 25  
|Item 7.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                        |  | 26  
|Item 7A.   |  | Quantitative and Qualitative Disclosures About Market Risk                                                   |  | 31  
|Item 8.    |  | Financial Statements and Supplementary Data                                                                  |  | 32  
|Item 9.    |  | Changes in and Disagreements With Accountants on Accounting and Financial Disclosure                         |  | 49  
|Item 9A.   |  | Controls and Procedures                                                                                      |  | 49  
|Item 9B.   |  | Other Information                                                                                            |  | 49  
|           | 
|PART III   |  | 50                                                                                                          
|Item 10.   |  | Directors and Officers of the Registrant                                                                     |  | 50  
|Item 11.   |  | Executive Compensation                                                                                       |  | 50  
|Item 12.   |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters               |  | 50  
|Item 13.   |  | Certain Relationships and Related Transactions                                                               |  | 50  
|Item 14.   |  | Principal Accountant Fees and Services                                                                       |  | 50  
|           | 
|PART IV    |  | 51                                                                                                          
|Item 15.   |  | Exhibits and Financial Statement Schedules                                                                   |  | 51  
|           | 
|Signatures |  | 52                                                                                                          



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PART I



This document contains
forward-looking statements that are based upon current expectations within the meaning of the Private Securities Reform Act of 1995. It is our intent that such statements be protected by the safe harbor created thereby and we disclaim any duty or
obligation to update. Forward-looking statements involve risks and uncertainties and our actual results and the timing of events may differ significantly from the results discussed in the forward-looking statements. Examples of such forward-looking
statements include, but are not limited to, statements about:



| |  |  | Our capital requirements and resources;
| | - |  | ---------------------------------------

| |  |  | Our strategy;
| | - |  | -------------

| |  |  | Development of new products;
| | - |  | ----------------------------

| |  |  | Our intent to develop and sell products and services to companies in the pharmaceutical industry;
| | - |  | -------------------------------------------------------------------------------------------------

| |  |  | Technological change and uncertainty of new and emerging technologies;
| | - |  | ----------------------------------------------------------------------

| |  |  | Potential competitors or products;
| | - |  | ----------------------------------

| |  |  | Future employment of our key employees;
| | - |  | ---------------------------------------

| |  |  | Future capital requirements;
| | - |  | ----------------------------

| |  |  | Development of strategic relationships;
| | - |  | ---------------------------------------

| |  |  | Statements about potential future dividends;
| | - |  | --------------------------------------------

| |  |  | Statements about protection of our intellectual property; and
| | - |  | -------------------------------------------------------------

| |  |  | Possible changes in legislation.
| | - |  | --------------------------------



Such forward-looking statements are inherently subject to risks and uncertainties, (including those discussed in Risk Factors below and other
sections of this document) and actual results and outcomes may differ materially from the results and outcomes discussed in or anticipated by the forward-looking statements.



Item 1.Business



The Company



We are an early stage
biopharmaceutical company engaged in the discovery, development and commercialization of complementary and alternative therapies for the treatment of three principal forms of carbohydrate intolerance  Type 2 diabetes,
Syndrome X, and impaired glucose tolerance (IGT), and their associated complications. We have been granted patents and filed patent applications for a number of proprietary formulations and combination therapies, including
formulations with existing diabetes medications, for use in the treatment of Type 2 diabetes. We intend to use our proprietary formulations to develop prescription treatments for Type 2 diabetes and related metabolic disorders. These
products are in an early stage of development and no regulatory filings to commercialize our products have yet been made with the United States Food and Drug Administration, or FDA, or any similar state or foreign authorities.



We have undertaken an initial clinical trial of one of our specific product
formulations, which demonstrated a consistent improvement in glycated hemoglobin levels (A1c), compared to base
line, after three months of treatment in a diabetic population. These formulations are covered by our issued patents as set forth below. This was a small (81 individual) open-label study. Open-label studies are generally considered to be less
reliable than double blind placebo controlled studies, and are not

accepted by the FDA. The observed reduction in A1c, (which is an established long-term measure of blood glucose), in this open-label study was in excess of 2% for all treatment groups. This reduction



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contemplates an average improvement in excess of 20% in blood glucose parameters in this patient population. This included patients taking the initial
product candidate as monotherapy, as well as with concomitant medications. We believe that this trial may suggest that Akesis formulations show the potential for enhancing currently available oral antidiabetic therapeutic agents. We intend to
conduct follow-on feasibility clinical trials with one or more of our formulations with a goal of confirming and extending the results of our initial clinical study. We believe that the successful completion of these feasibility trials could lead to
partnering opportunities in the pharmaceutical industry. We are not currently in discussions with the FDA regarding the specific requirements for approval and we have not commenced any FDA-approved clinical trials.



Diabetes



Diabetes is a major health problem and is the fifth leading cause of death by disease in the United States. Diabetes is
characterized by poor control of glucose levels in the blood, and is often associated with severe long-term complications, such as heart, eye, kidney and peripheral vascular diseases.



It is estimated that over 194 million people worldwide have diabetes. Of that population, approximately 18 million
have Type 1 diabetes, also known as juvenile-onset diabetes, and approximately 159 million have Type 2 diabetes, also known as adult-onset diabetes. In the United States alone, in 2002 there were approximately 13 million people
diagnosed with diabetes, and approximately 1.3 million new cases of diabetes are diagnosed each year. CDC estimates that in 2005 direct and indirect costs related to diabetes will be in excess of 150 billion dollars.



For people suffering from diabetes, poor control of blood glucose
concentrations has been shown to result in severe long-term complications. For instance, damage to small blood vessels due to diabetes may result in disorders such as retinopathy, nephropathy, neuropathy, and peripheral vascular disease.



Weight control and obesity are also major problems for patients with
diabetes, particularly for those people using insulin as part of their treatment regimen. Other metabolic complications resulting from diabetes and associated metabolic disorders include high blood pressure and dyslipidemia, the abnormal metabolism
of fat. These undesired metabolic effects may result in additional complications involving large blood vessels, which can lead to heart attacks, strokes and amputations of lower extremities. Further, patients with diabetes frequently have wide
fluctuations in blood sugar following meals. These fluctuations in blood sugar can significantly affect a patients quality of life. Collectively, these complications and associated metabolic disorders can lead to increased pain, suffering,
reduced quality of life and early death.



The most widely
accepted measure of long-term blood glucose is glycated hemoglobin, or A1c. A persons A1clevel is a recognized indicator of that individuals average blood glucose concentrations over a 3 to 4-month period.
Lower A1clevels indicate better blood glucose control, on average. A1clevels in people without diabetes are usually less than 6%. The American Diabetes Associations Clinical Practice Recommendations suggest that people with
diabetes should aim for an A1clevel that is lower than 7%. Only a minority of people diagnosed with diabetes in the
United States are able to achieve the American Diabetes Associations recommended target A1clevel, even with
available drug therapies. Additionally, aggressive use of insulin and other available therapies to achieve target glucose control can be associated with an increased risk of hypoglycemia and weight gain. Consequently, there is a pressing need to
develop new treatment strategies that improve the overall health profile of patients with diabetes and reduce the risk of complications without increased pain and suffering.



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In 1993, a landmark study in patients with Type 1 diabetes, called the Diabetes Control and
Complications Trial, showed that improved glucose control  as measured by any reduction in an individuals A1clevel  reduced the incidence of long-term complications. In 1998, a similar landmark study in patients with Type 2 diabetes, the United Kingdom Prospective Diabetes Study, reported similar conclusions for Type 2
diabetes. Unfortunately, both of these studies showed that available therapies cannot mitigate the progressive nature of diabetes and long-term complications are to be expected.



Product Description



The initial product we developed is a patented combination of micronutrients, the individual components of which have been used widely for many years. It
is consumable in tablet form. It includes components that are believed to address (i) immediate health needs, (ii) longer-term health-maintenance issues, and (iii) aspects of general health and well-being. The product candidate has to
date been sold as a dietary supplement under the 1994 Dietary Supplement Health and Education Act (DSHEA). Preliminary evidence suggests that it may be effective at promoting diabetic health and wellness when used as a stand-alone
product, as well as when used as an adjunct to prescription anti-diabetic products, both oral and insulin.



It is contemplated that our new product formulations will be derived from the more recent patent issuances. We plan to evaluate metformin containing
compositions for the treatment of diabetes. This will be an Rx combination of metformin, chromium, vanadium, and magnesium. The product will be taken orally, once or BID in tablet form. Our second product to be evaluated through the proposed
feasibility study will be a combination of glimepride, chromium and vanadium. This product will also be considered for prescription use and be taken orally in tablet form.



The product candidates under consideration are being developed in response to the increasing number of cases of diabetes and
attempt to improve health and wellness without requiring substantial lifestyle changes. They do so by delivering a core micronutrient offering that appears to be important for maintaining good diabetic control.



The anchor components of the initial product candidate are intended to
mitigate insulin resistance, and include chromium (from its polynicotinate complex), magnesium (as highly-bioavailable salts) and vanadium (as its sulfate). These anchor components are supported by additional micronutrients that may support
longer-term health and focus on cardiovascular benefits, specifically aspirin source and vitamin E (in its natural isomeric form).



The initial patented product formulation which had been tested by us is presented below:



|                                                                      |  |         |  |            
|--------------------------------------------------------------------- |  | ------- |  | -----------
|Ingredient                                                            |  | Amount  |  | Daily Value
|Biotin                                                                |  | 300 μg  |  | 100%       
|Calcium (from calcium carbonate/phosphate)                            |  | 150 mg  |  | 15%        
|Chromium (from polynicotinate complex)                                |  | 333 μg  |  | 278%       
|Copper (from copper chelate)                                          |  | 2 mg    |  | 100%       
|Folic Acid                                                            |  | 400 μg  |  | 100%       
|Iodine (from sea kelp)                                                |  | 150 μg  |  | 100%       
|Magnesium (from citrate/fumarate/malate/glutarate/succinate complex)  |  | 46 mg   |  | 12%        
|Manganese (from manganese sulfate)                                    |  | 11 mg   |  | 550%       
|Molybdenum (from citrate/fumarate/malate/glutarate/succinate complex) |  | 75 μg   |  | 100%       
|Niacinamide                                                           |  | 20.1 mg |  | 101%       



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|                                                                    |  |         |  |            
|------------------------------------------------------------------- |  | ------- |  | -----------
|Ingredient                                                          |  | Amount  |  | Daily Value
|Pantothenic Acid (as calcium pantothenate)                          |  | 10 mg   |  | 100%       
|Phosphorous (from calcium phosphate)                                |  | 115 mg  |  | 12%        
|Riboflavin                                                          |  | 3.6 mg  |  | 212%       
|Selenium (from citrate/fumarate/malate/glutarate/succinate complex) |  | 60 μg   |  | 86%        
|Standardized Willow/Willow Bark Complex (aspirin source)            |  | 160 mg  |  | N/A        
|Thiamine (mononitrate)                                              |  | 3 mg    |  | 200%       
|Vandyl Sulfate (hydrate)                                            |  | 100 mg  |  | N/A        
|Vitamin A                                                           |  | 5000 IU |  | 100%       
|Vitamin B-6 (as pyridoxineHCl)                                     |  | 23.1 mg |  | 1155%      
|Vitamin B-12                                                        |  | 48 μg   |  | 800%       
|Vitamin C (ascorbic acid)                                           |  | 60 mg   |  | 100%       
|Vitamin D-3                                                         |  | 400 IU  |  | 100%       
|Vitamin E (natural)                                                 |  | 400 IU  |  | 1333%      
|Zinc                                                                |  | 15 mg   |  | 100%       



Chromium and
vanadium supplements in diabetes treatment



The first
studies to suggest that chromium supplementation, (with chromium picolinate) could have beneficial effects on body mass and glucose metabolism were published in 1989. Chromium supplementation has been proposed to help with weight loss, glycemic
control in diabetes, athletic performance, controlling hypercholesterolemia, corticosteroid-induced hyperglycemia and improving lean muscle mass. However many subsequent studies of chromium picolinate have failed to support these earlier findings.



There is now reasonable evidence to suggest that chromium
deficiency may be associated with the development, or progression of diabetes, and that supplementation with chromium can exert positive effects on insulin sensitivity, blood glucose levels and glycosylated hemoglobin levels in diabetic patients.
However, there is as of yet no clear picture of whether populations susceptible to diabetes are chromium deficient, or what long term dosing is appropriate to treat or prevent diabetes, or what the long term side effects of chromium supplementation
may arise.



The most commonly used form of chromium in health
supplements is chromium picolinate, and this is significantly more bioavailable than elemental chromium. It is rapidly absorbed in the stomach, and subsequently absorbed into tissues, where it rapidly distributes within cells. Pharmacokinetic models
predict that ingested chromium will accumulate and be retained in human tissues if the supplement is taken for extended periods of time; however this prediction has not been experimentally confirmed.



Accurate estimates of chromium levels in humans are difficult to determine,
and tissue chromium levels do not necessarily correlate with serum chromium levels. The U.S. Food and Nutrition Board of the National Academy of Sciences concluded in 2001 that there was not enough existing evidence to set Recommended Daily
Allowances (RDAs) for chromium and, instead set Adequate Intakes (AIs) based on the amount of chromium that normal healthy people currently consume. Based on that data, the Institute of Medicine recommended AIs of chromium of 25-35
micrograms per day (μg or mcg).



The nutritional
biochemistry and mechanism of action of chromium in the body is still poorly understood. No enzymes have been formally identified that require chromium for activity, and no chromium dependent co-factors have been biochemically characterized.
Chromium has been shown to activate the tyrosine kinase activity of insulin activated insulin receptors and to activate a membrane phosphotyrosine phosphatase in adipocyte membranes. The physiological actions of chromium on



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insulin sensitivity and diabetes may also be mediated through the interaction of chromium on the transport, storage and intracellular uptake of iron.
Chromium supplementation competes with iron for transport through transferrin and acts to reduce iron storage in the body. Excess iron accumulation has been linked to diabetes and insulin insensitivity in some studies, suggesting that the beneficial
effects of chromium supplementation may be related to the short term reduction of iron accumulation, particularly in the elderly.



Chromium is considered safe up to doses of 1000 μg (1 mg) per day. However, the use of chromium picolinate has been associated with toxicity,
especially at high doses in vitro, possibly through the release of the picolinate ligand, which can independently act as an oxidant.



In March 2003 the Expert Group on Vitamins and Minerals of the U.K. Joint Food Standards and Safety Group requested that the health supplement industry
should voluntarily withdraw products containing chromium picolinate while also consulting on a ban on the use and sale of chromium picolinate in the U.K. Currently the U.S. Food and Drug Administration, working with the U.S. National Academy of
Sciences, is studying the potential regulation of chromium picolinate.



In summary, the long term biological effects of chromium accumulation in humans are poorly understood, and there have not yet been any long term studies on the effects of chromium supplementation. There is no conclusive proof, as evidenced
by a large long-term controlled clinical trial, demonstrating that the benefits of high dose chromium supplementation for the treatment of diabetes significantly outweigh the risk of chromium toxicity. Because of insufficient information on the use
of chromium to treat diabetes, no recommendations for supplementation yet exists in the U.S. for diabetes treatment.



Vanadium does not appear to be an essential element, there are no disorders in humans associated with vanadium deficiency and the government has not
established a recommended daily allowance (RDA). The normal diet contains 10-30 micrograms (μg or mcg) of vanadium per day. The reported Tolerable Upper limit (ULs) for vanadium is approximately 1.8 mg/day for an adult.



Sodium vanadate was first reported to be effective for treating diabetes in
1899, almost 100 years before the discovery of chromium picolinate. Many subsequent studies have shown that a number of vanadium compounds have insulin mimicking actions both in vitro and in vivo. Treatment with vanadium compounds such
as vanadium sulfate resulted in the development of a modest increase in insulin sensitivity and decreased insulin requirements.



Vanadium has been proposed to act through at least three mechanisms: 1) a direct insulin-mimetic action, 2) an enhancement of insulin
sensitivity, and 3), a prolongation of insulin biological response. The insulin mimetic action appears to be mediated by direct binding of vanadium, or vanadium complexes with low molecular serum proteins to the insulin receptor. The synergistic
enhancement of insulin sensitivity and prolongation of insulin response appear to be mediated via an inhibitory action of vanadate on phosphoprotein tyrosine phosphatases (PTPs) which would otherwise act to switch off the intracellular effects of
insulin within the cell.



Vanadium salts such as vanadyl sufate
appear to be poorly absorbed through the gastrointestinal tract, with less than 5% of the absorbed dose being taken up. The use of enteric coated vanadyl sufate capsules has been shown to approximately double the uptake of vanadate sulfate. Absorbed
vanadate has been shown to bind to transferrin and ferritin in plasma and other body fluids. Absorbed vanadium is mainly excreted in the urine in both high and low molecular weight complexes. Long term administration of vanadium results in the
accumulation of vanadium in bone.



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There is currently limited data on the long term toxicity of vanadium in humans. Vanadate appears to
accumulate in bones and in clinical trials gastrointestinal side effects increase above doses of 75 mg / day. In one clinical trial, gastrointestinal side effects were experienced in 75% of the subjects in the first week, but well tolerated after
that. In another study 12 subjects were given 13.5 mg daily for 2 weeks, followed by 22.5 mg daily for 5 months. Five developed gastrointestinal symptoms  nausea, vomiting, diarrhea, cramps  and five developed green tongues.



We believe, based on our initial studies, that chromium and
vanadium supplementation may provide synergistic effects when administered in combination with other diabetes therapeutics, potentially making many existing therapeutic strategies for treating diabetes more effective.



Target Markets



The initial product candidate is targeted at individuals with the three
principal forms of carbohydrate intolerance  Type 2 diabetes, Syndrome X, and impaired glucose tolerance (IGT). Collectively, these conditions are found in one of every five or six individuals, and they are regarded
by some analysts as significant growth engines for the human-health industry. All three of these market segments have clear needs and have articulated demands for product offerings that deliver benefits such as those that may be available through
the product candidates.



Type 2 diabetes is endemic in
modern industrialized countries and, by many estimates, represents >95% of the diabetic population. There are an estimated 15 million or more individuals with Type 2 diabetes in the US and upward of 150 million individuals
worldwide. General agreement exists that this population will more than triple during the next 25 years. Annual sales of oral anti-diabetic agents currently are on the order of $10 billion in the US.



Syndrome X is intermediate between Type 2 diabetes and IGT, and may
represent a market of at least 30 million individuals in the US. Some recent studies have suggested that this condition is linked to 13 million or more cardiovascular disease cases, which would implicate Syndrome X in at least half of
those reported.



Impaired glucose tolerance is an even larger
market segment, as this condition affects at least 35 million individuals in the US. It has become an increasing area of focus by the American Diabetes Association (ADA), which has advocated the identification and intensive
management of the health and wellness of individuals with IGT.



At a more general level, the product candidate is tied to health-management trends that are (or are becoming) mainstream. It is aligned perfectly with an aging consumer population that cares more than ever about staying healthy and active.



Safety Findings



All components in the product candidate are found in food articles that
either are part of standard diets or are found in widely-available dietary supplements that are legally marketed and sold, and that have extensive clinical and/or safety-in-use histories. Safe consumption of individual and combination micronutrients
at levels equivalent to and in excess of those found in the product candidate is documented over decades and, in some cases, centuries. No consistent reports specifically linking any of the product candidates components to adverse events are
found in reports deposited with FDA and other regulatory bodies responsible for maintaining such data.



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For consumers with aspirin sensitivities or allergies, it should be noted that the initial product
candidate contains a standardized willow/willow bark (willow) complex that is metabolized to acetylsalicylic acid, the active ingredient in aspirin. Willow is used in the initial product candidate at an equivalent of 20 mg aspirin to
confer long-term cardioprotective benefits, which are advocated for people with diabetes by the ADA and the American Heart Association.



Reports of gastrointestinal upset have been made about individual micronutrients in the initial product candidate; however they generally are ameliorated
or eliminated by concomitant food consumption or after a brief adaptation period.



We used WIL Laboratories, a contract toxicology organization, to perform a preliminary animal safety study with the product. The results from a good laboratory practices (GLP) 14-day rat toxicology study (n = 70
rats) showed a clean profile when it was administered at levels up to 20X those intended for humans, a regimen recommended by the professional staff at WIL as providing an appropriate margin of safety. Specifically, the results from this study
indicated that the product candidate was taken up by study animals and that no adverse observations were noted in a comprehensive examination of tissues, organs, and fluids. Furthermore, all histopathological examinations were completely normal.



Based on the foregoing, we do not anticipate any safety issues
related to the product candidate. However, the precise combination of micronutrients in the product candidate has not been clinically tested in humans. Accordingly, there can be no guarantee that toxicity issues will not arise or that results of
human clinical trials of the product candidate will be consistent with the results obtained to date.



Preliminary Clinical Data



We performed a small (81 individual), 12-week open-label human study of our initial product, which provided preliminary but encouraging insight about
its efficacy. This study was conducted over Thanksgiving and Christmas holidays, a period during which many diabetic individuals experience significant deteriorations of their diabetic control. Participants added the product candidate to their daily
treatment regimen while making no changes to existing medications, diets, or exercise regimens.



Open-label studies can be used to make initial assessments about product efficacy, and are performed with prior physician and participant understanding
that a product is being used that is expected to deliver health benefits. They differ from double-blind placebo-controlled trials, which are the industry-standard approach for testing prescription drugs and in which neither physicians nor patients
know whether patients are taking a placebo or the product under investigation.



Open-label studies are generally considered to be less reliable than double blind placebo-controlled trials, and are not accepted by the FDA.



Participants for this study came from hospitals and physician practices in La Jolla, CA; Pittsburgh, PA; Las Vegas, NV; and
Chicago, IL. Summary participant information is presented below:



|                                 |  |             
|-------------------------------- |  | ------------
|Number of Participants           |  | 81          
|                                 | 
|Study Duration (Weeks)           |  | 12          
|                                 | 
|Average Age (Range)              |  | 61 (26  81)
|                                 | 
|Gender (M/F)                     |  | 41/40       
|                                 | 
|Average Disease Duration (Range) |  | 7 (0  24)  
|                                 | 
|Type 2/Type 1 Diabetes           |  | 81/0        
|                                 | 
|Taking concomitant medications   |  | 88%         



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The endpoint measured in the open-label study was hemoglobin A1c(HbA1c), which is the generally accepted standard against which diabetic control is evaluated. It provides a measure of average blood glucose readings throughout the previous 90 days. A generally accepted HbA1crange for the non-diabetic population is 4.5%  7.5%. Values above 10.0% (correlating to an average blood glucose of 250
mg/dL) are observed in a large part of the diabetic population, and values above even 8.0% typically are precursors to serious micro-and macro-vascular complications.



The table below presents summary results of the improved diabetic control (as measured by reductions in HbA1c) that was delivered by the product candidate across various cross-sections of open-label study groups:



|                                                           |  |                 |  
|---------------------------------------------------------- |  | --------------- | -
|Population                                                 |  | Change in HbA1c |  
|Entire                                                     |  | -1.7            | %
|Those with starting HbA1c> 8.0%                            |  | -2.2            | %
|Those taking only the Akesis product candidate             |  | -2.0            | %
|Those taking one concomitant prescription anti-diabetic    |  | -2.1            | %
|Those taking three concomitant prescription anti-diabetics |  | -1.3            | %



To provide context for
these results, the following table compares the improvements in diabetic control delivered by the product candidate in the open-label study, when taken as the only product for diabetic control (as monotheraphy), with those delivered by prescription
anti-diabetics taken as monotheraphy. Data for these prescriptions agents are taken from much larger and sometimes longer double-blind placebo-controlled studies. Accordingly, the data from these other studies is much more likely to be accurate than
the data from our study. Further trials will need to be done to verify that the results with the product candidate are valid in larger populations and in longer-duration studies.



|                         |  |                        |  |                 |  
|------------------------ |  | ---------------------- |  | --------------- | -
|Product                  |  | Study Duration (Weeks) |  | Change in HbA1c |  
|Akesis product candidate |  | 12                     |  | -2.0            | %
|Glucophage®              |  | 29                     |  | -1.4            | %
|Rezulin®                 |  | 26                     |  | -1.0            | %
|                         |  | 12                     |  | -0.8            | %
|Avandia®                 |  | 26                     |  | -0.7            | %
|                         |  | 26                     |  | -0.6            | %
|Prandin                 |  | 12                     |  | -0.6            | %



The small size of the
participant population for our study, combined with its being an open-label protocol, make it difficult to draw broad, statistically-significant conclusions. However, the Company believes the Akesis study indicates the following:



| | 1. | The product candidate may be efficacious, with activity that may be comparable to those delivered by prescription anti-diabetics.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------



| | 2. | The product candidate may be equally efficacious across all demographics (e.g., age, gender, weight, duration of condition, starting HbA1c, number/type of concomitant anti-diabetic medications).
| | -- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | The product candidate appears to be most effective in populations that are of greatest interest to the health- and managed-care industries  younger individuals, those
with more recent onsets of diabetes, and individuals with higher baseline HbA1cs.
| | -- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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In order to test the product candidate under more demanding conditions, a randomized, double-blind,
placebo-controlled, good clinical practices (GCP) human trial was conducted at Duke University on a pilot scale (n = 18 patients). The study evaluated the addition of the product candidate to an otherwise-unchanged diabetes-control program.
Results from this trial were interpreted by Clinimetrics, an independent contract-research organization. Although this study was small by design, the Company believes the results may warrant undertaking larger similar studies.



Specifically, this blinded, placebo-controlled study made a stronger
statement than trend-line information that generally is obtained from pilot trials. The treatment arm showed appreciably-improved HbA1c values v. placebo (median improvement 1.0%, mean improvement 1.2%), although this improvement was not
statistically significant (p = 0.07) due to the small sample size.



In summary, based on this preliminary clinical data, the Company believes that consumption of the product candidate may be an effective approach to improving the health of individuals with various manifestations of carbohydrate intolerance.
However, there can be no assurance that the results of more extensive human studies will be consistent with those obtained thus far.



Patents, Proprietary Rights, and Licenses



We believe that patents and other proprietary rights are important to our business. Our policy is to file patent applications to protect technology,
inventions and improvements that may be important to the development of our business. We also rely upon trade secrets, know-how, continuing technological innovations and licensing opportunities to develop and maintain our competitive position. We
plan to enforce our issued patents and our rights to proprietary information and technology.



Our core technology is covered by four issued U.S. patents, and we have one additional patent application pending. Each of these patents consist of method and composition claims. A summary of our intellectual property
is as follows:



|             |  |                                                                 |  |                 |  |              |  |                                                                                                                                            |  |                                   
|------------ |  | --------------------------------------------------------------- |  | --------------- |  | ------------ |  | ------------------------------------------------------------------------------------------------------------------------------------------ |  | ----------------------------------
|Patent No.   |  | Title                                                           |  | ApplicationDate |  | ApprovalDate |  | Summary                                                                                                                                    |  | Target Market                     
|US 5,962,030 |  | Dietary Supplement and method of treatment for diabetic control |  | 11/05/97        |  | 5/10/99      |  | Claims dietary supplements for improving glucose metabolism comprising chromium, magnesium, and vanadium and at least one other ingredient |  | Over the Counter Supplement market
|US
6,203,819 |  | Dietary Supplement and method of treatment for diabetic control |  | 3/19/99         |  | 3/20/2001    |  | Claims dietary supplements for improving glucose metabolism comprising chromium, vanadium and aspirin                                      |  | Over the Counter Supplement market



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|             |  |                                                                        |  |                 |  |              |  |                                                                                                                  |  |                                                                          
|------------ |  | ---------------------------------------------------------------------- |  | --------------- |  | ------------ |  | ---------------------------------------------------------------------------------------------------------------- |  | -------------------------------------------------------------------------
|Patent No.   |  | Title                                                                  |  | ApplicationDate |  | ApprovalDate |  | Summary                                                                                                          |  | Target Market                                                            
|US 6,376,549 |  | Metformin-containing compositions for the treatment of diabetes        |  | 10/17/1998      |  | 4/23/2002    |  | Claims compositions for the treatment of diabetes comprising metformin, magnesium, chromium and vanadium         |  | Prescription diabetes market, particularly combination therapy approaches
|US
6,852,760 |  | Compositions and methods for treatment of glucose metabolism disorders |  | 10/17/99        |  | 2/8/05       |  | Claims compositions for the treatment of diabetes comprising a sulfonylurea class of drug, chromium and vanadium |  | Prescription diabetes market, particularly combination therapy
approaches



Drugs. The FDA
and comparable regulatory agencies in state and local jurisdictions and in foreign countries impose substantial requirements upon the clinical development, manufacture, marketing and distribution of drugs. These agencies and other federal, state and
local entities regulate research and development activities and the testing, manufacture, quality control, safety, effectiveness, labeling, storage, record keeping, approval, advertising and promotion of our drug candidates.



In the United States, the FDA regulates drugs under the Federal Food, Drug,
and Cosmetic Act, or FFDCA, and implementing regulations. The process required by the FDA before our drug candidates may be marketed in the United States generally involves the following:



| |  |  | completion of extensive preclinical laboratory tests, preclinical animal studies and formulation studies; all performed in accordance with the FDAs good laboratory practice,
or GLP, regulations;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an IND application which must become effective before clinical trials may begin;
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | performance of adequate and well-controlled clinical trials to establish the safety and efficacy of the product candidate for each proposed indication;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | submission of a NDA to the FDA;
| | - |  | -------------------------------



| |  |  | satisfactory completion of an FDA preapproval inspection of the manufacturing facilities at which the product is produced to assess compliance with current GMP, or cGMP,
regulations; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | FDA review and approval of the NDA prior to any commercial marketing, sale or shipment of the drug.
| | - |  | ---------------------------------------------------------------------------------------------------



The testing and approval process requires substantial time, effort and financial resources, and we cannot be certain that
any approvals for our drug candidates will be granted on a timely basis, if at all.



Preclinical tests include laboratory evaluation of product chemistry, formulation and stability, as well as studies to evaluate toxicity in animals. The results of preclinical tests, together with manufacturing
information and analytical data, are submitted as part of an IND application to the FDA.



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The IND automatically becomes effective 30 days after receipt by the FDA, unless the FDA, within the
30-day time period, raises concerns or questions about the conduct of the clinical trial, including concerns that human research subjects will be exposed to unreasonable health risks. In such a case, the IND sponsor and the FDA must resolve any
outstanding concerns before the clinical trial can begin. Our submission of an IND, or those of our collaborators, may not result in FDA authorization to commence a clinical trial. A separate submission to an existing IND must also be made for each
successive clinical trial conducted during product development, and the FDA must grant permission before each clinical trial can begin. Further, an independent institutional review board, or IRB, for each medical center proposing to conduct the
clinical trial must review and approve the plan for any clinical trial before it commences at that center and it must monitor the study until completed. The FDA, the IRB, or the sponsor may suspend a clinical trial at any time on various grounds,
including a finding that the subjects or patients are being exposed to an unacceptable health risk. Clinical testing also must satisfy extensive Good Clinical Practice, or GCP, regulations and regulations for informed consent.



Clinical Trials. For purposes of NDA submission and approval, clinical
trials are typically conducted in the following three sequential phases, which may overlap:



| |  |  | Phase I: Studies are initially conducted in a limited population to test the drug candidate for safety, dose tolerance, absorption, metabolism, distribution and excretion in
healthy humans or, on occasion, in patients, such as cancer patients. In some cases, particularly in cancer trials, a sponsor may decide to run what is referred to as a Phase Ib evaluation, which is a second safety-focused Phase I
clinical trial typically designed to evaluate the impact of the drug candidate in combination with currently approved drugs.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase II: Studies are generally conducted in a limited patient population to identify possible adverse effects and safety risks, to determine the efficacy of the drug candidate
for specific targeted indications and to determine dose tolerance and optimal dosage. Multiple Phase II clinical trials may be conducted by the sponsor to obtain information prior to beginning larger and more expensive Phase III clinical
trials. In some cases, a sponsor may decide to run what is referred to as a Phase IIb evaluation, which is a second, confirmatory Phase II clinical trial that could, if positive and accepted by the FDA, serve as a pivotal
clinical trial in the approval of a drug candidate.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase III: These are commonly referred to as pivotal studies. When Phase II clinical trials demonstrate that a dose range of the drug candidate is effective and has an
acceptable safety profile, Phase III clinical trials are undertaken in large patient populations to further evaluate dosage, to provide substantial evidence of clinical efficacy and to further test for safety in an expanded and diverse patient
population at multiple, geographically dispersed clinical trial sites.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



In some cases, the FDA may condition approval of a NDA for a drug candidate on the sponsors agreement to conduct additional clinical trials to further assess the drugs safety and effectiveness after NDA
approval. Such post-approval trials are typically referred to as Phase IV clinical trials.



New Drug Application. The results of drug candidate development, preclinical testing and clinical trials are submitted to the FDA as part of a NDA.
The NDA also must contain extensive manufacturing information. Once the submission has been accepted for filing, by law the FDA has 180 days to review the application and respond to the applicant. The review process is often significantly extended
by FDA requests for additional information or clarification. The FDA may refer the NDA to an advisory committee for review, evaluation and recommendation as to whether the application should be



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approved. The FDA is not bound by the recommendation of an advisory committee, but it generally follows such recommendations. The FDA may deny approval of a
NDA if the applicable regulatory criteria are not satisfied, or it may require additional clinical data or an additional pivotal Phase III clinical trial. Even if such data are submitted, the FDA may ultimately decide that the NDA does not satisfy
the criteria for approval. Data from clinical trials are not always conclusive and the FDA may interpret data differently than we or our collaborators interpret data. Once issued, the FDA may withdraw drug approval if ongoing regulatory requirements
are not met or if safety problems occur after the drug reaches the market. In addition, the FDA may require testing, including Phase IV clinical trials, and surveillance programs to monitor the effect of approved products which have been
commercialized, and the FDA has the power to prevent or limit further marketing of a drug based on the results of these post-marketing programs. Drugs may be marketed only for the approved indications and in accordance with the provisions of the
approved label. Further, if there are any modifications to the drug, including changes in indications, labeling, or manufacturing processes or facilities, we may be required to submit and obtain FDA approval of a new NDA or NDA supplement, which may
require us to develop additional data or conduct additional preclinical studies and clinical trials.



Satisfaction of FDA regulations and requirements or similar requirements of state, local and foreign regulatory agencies typically takes several years and
the actual time required may vary substantially based upon the type, complexity and novelty of the product or disease. Typically, if a drug candidate is intended to treat a chronic disease, as is the case with some of the drug candidates we are
developing, safety and efficacy data must be gathered over an extended period of time. Government regulation may delay or prevent marketing of drug candidates for a considerable period of time and impose costly procedures upon our activities. The
FDA or any other regulatory agency may not grant approvals for new indications for our drug candidates on a timely basis, if at all. Even if a drug candidate receives regulatory approval, the approval may be significantly limited to specific disease
states, patient populations and dosages. Further, even after regulatory approval is obtained, later discovery of previously unknown problems with a drug may result in restrictions on the drug or even complete withdrawal of the drug from the market.
Delays in obtaining, or failures to obtain, regulatory approvals for any of our drug candidates would harm our business. In addition, we cannot predict what adverse governmental regulations may arise from future United States or foreign governmental
action.



Other regulatory requirements. Any drugs
manufactured or distributed by us or our collaborators pursuant to FDA approvals are subject to continuing regulation by the FDA, including recordkeeping requirements and reporting of adverse experiences associated with the drug. Drug manufacturers
and their subcontractors are required to register their establishments with the FDA and certain state agencies, and are subject to periodic unannounced inspections by the FDA and certain state agencies for compliance with ongoing regulatory
requirements, including cGMPs, which impose certain procedural and documentation requirements upon us and our third-party manufacturers. Failure to comply with the statutory and regulatory requirements can subject a manufacturer to possible legal or
regulatory action, such as warning letters, suspension of manufacturing, seizure of product, injunctive action or possible civil penalties. We cannot be certain that we or our present or future third-party manufacturers or suppliers will be able to
comply with the cGMP regulations and other ongoing FDA regulatory requirements. If our present or future third-party manufacturers or suppliers are not able to comply with these requirements, the FDA may halt our clinical trials, require us to
recall a drug from distribution, or withdraw approval of the NDA for that drug.



The FDA closely regulates the post-approval marketing and promotion of drugs, including standards and regulations for direct-to-consumer advertising, off-label promotion, industry-sponsored



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scientific and educational activities and promotional activities involving the Internet. A company can make only those claims relating to safety and efficacy
that are approved by the FDA. Failure to comply with these requirements can result in adverse publicity, warning letters, corrective advertising and potential civil and criminal penalties. Physicians may prescribe legally available drugs for uses
that are not described in the drugs labeling and that differ from those tested by us and approved by the FDA. Such off-label uses are common across medical specialties. Physicians may believe that such off-label uses are the best treatment for
many patients in varied circumstances. The FDA does not regulate the behavior of physicians in their choice of treatments. The FDA does, however, impose stringent restrictions on manufacturers communications regarding off-label use.



Dietary Supplements. The FDA regulates dietary
supplements under the Dietary Supplement Health and Education Act of 1994, or DSHEA. DSHEA describes a dietary supplement as a product (other than tobacco) that is:



| |  |  | intended to supplement the diet that bears or contains one or more of the following dietary ingredients: a vitamin, a mineral, an herb or other botanical, an amino acid, a dietary
substance for use by man to supplement the diet by increasing the total daily intake, or a concentrate, metabolite, constituent, extract, or combinations of these ingredients;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | intended for ingestion in pill, capsule, tablet, or liquid form;
| | - |  | ----------------------------------------------------------------



| |  |  | not represented for use as a conventional food or as the sole item of a meal or diet; and
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | labeled as a dietary supplement.
| | - |  | ----------------------------------



Under DSHEA, a manufacturer is not required to establish that a dietary supplement is safe or effective before the product can be marketed and the FDA
does not have preapproval authority and does not scrutinize a dietary supplement before it enters the market. The FDA is permitted to restrict the sale of a dietary supplement or dietary ingredient if it poses a significant and unreasonable
risk under the conditions of use on the label or as commonly consumed.



Dietary supplement manufacturers are not allowed to make claims that the product is intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease. Claims that suggest such an intended use
subject the dietary supplement to regulation as a drug. Such a product becomes illegal if it fails to comply with all drug requirements, including the requirements for FDA approval of a NDA prior to marketing. Failure to comply with the requirements
of DSHEA can subject a manufacturer to possible legal and regulatory action, such as warning letters, suspension of manufacturing, seizure of product, injunctive action or possible civil and criminal penalties.



Competition



Biotechnology and pharmaceutical companies are highly competitive. There are
many pharmaceutical companies, biotechnology companies, public and private universities and research organizations actively engaged in the research and development of products that may compete with our products. A number of our largest competitors,
including Bristol-Myers Squibb Company, GlaxoSmithKline plc, Eli Lilly and Company, Merck & Co., Novartis AG, Novo Nordisk A-S and Takeda Pharmaceuticals, are pursuing the development of, or are marketing, pharmaceuticals that target the
same diseases that we are targeting, and it is possible that the number of companies seeking to develop products and therapies for the treatment of diabetes, obesity, and cardiovascular disease will increase. A number of supplement makers including
Nutrition 21, have developed, or are developing similar products to ours. The government, through the National Center for Complementary and



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alternative Medicine (NCCAM) funds a variety of private, and for-profit, and academic groups to conduct trials on chromium supplementation and related
alternative approaches to treat diabetes.



Many of these and
other existing or potential competitors have substantially greater financial, technical and human resources than we do and may be better equipped to develop, manufacture and market products. These companies may develop and introduce products and
processes competitive with or superior to ours. In addition, other technologies or products may be developed that have an entirely different approach or means of accomplishing the intended purposes of our products, which might render our technology
and products noncompetitive or obsolete.



If approved for
marketing, our proprietary formulations may compete with established therapies for market share. In addition, many companies are pursuing the development of novel pharmaceuticals that target diabetes. These companies may develop and introduce
products competitive with or superior to our proprietary formulations. Such competitive or potentially competitive products include: acarbose, nateglinide, metformin, miglitol, pioglitazone, repaglinide, rosiglitazone, sulfonyureas, and symlin.



Employees



As of March 15, 2006, we had 2 employees. All of these employees are in
general and administrative positions. All of our management employees and members of our Board of Directors have prior experience with pharmaceutical and biotechnology companies. None of our employees are covered by collective bargaining agreements,
and our management considers relations with our employees to be good.



Item 1A.Risk Factors



Our future operating results may vary substantially from anticipated results due to a number of factors, many of which are beyond our control. The following discussion highlights some of these factors and the
possible impact of these factors on future results of operations. You should carefully consider these factors before making an investment decision. If any of the following factors actually occur, our business, financial condition or results of
operations could be harmed. In that case, the price of our common stock could decline, and you could experience losses on your investment.



We have a history of operating losses, anticipate future losses, may not generate revenues from product sales and may never become profitable.



We have experienced significant operating losses in each period since our
inception. As of December 31, 2005, we have incurred total losses of $5.9 million. We expect these losses to continue and it is uncertain when, if ever, we will become profitable. These losses have resulted principally from costs incurred
in conducting the initial open-label clinical trials, stock-based compensation for our executive officers and from general and administrative costs associated with operations. We expect to incur increasing operating losses in the future as a result
of expenses associated with clinical trials (see the Liquidity and Capital Resources section of this report below) as well as general and administrative costs. Even if we do achieve profitability, we may not be able to sustain or increase
profitability on a quarterly or annual basis.



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We will require future capital and are uncertain of the availability or terms of additional funding, and if additional
capital is not available or not available on acceptable terms, we may have to reduce the size of our operations.



As of December 31, 2005, we have no long-term financial commitments. Currently, we are actively seeking to raise $150,000 through a private placement
of our common stock. Pending internal review of our regulatory strategy, we may seek to proceed with additional feasibility clinical trials of our proposed products, which will require extensive additional funding. See the Liquidity and Capital
Resources section of this report below. There can be no assurance that we will be able to raise additional financing. If we are unable to raise any additional financing, our current cash resources should enable us to continue operations based on our
current level of commitments into the first half of 2007.



We
may require substantial additional capital to finance future growth and fund ongoing operations through the remainder of 2006 and beyond. In particular, we may issue a substantial number of additional shares and warrants to raise additional
financing in the first half of 2006 and we have little control over the timing of any resales of such shares. As a result, the market price of our common stock may fall if a large portion of those shares is sold in the public market. We may raise
additional funds through public or private financing, strategic relationships or other arrangements. We cannot be certain that the funding will be available on attractive terms, or at all. Furthermore, any additional equity financing may be dilutive
to shareholders, and debt financing, if available, may involve restrictive covenants. Strategic arrangements, if necessary to raise additional funds, may require us to relinquish our rights to certain of our technologies or products. If we fail to
raise capital when needed, our business will be negatively affected, which could cause the price of our common stock to decline.



We are currently assessing various prospective product formulations. We will require additional capital to fund the development and commercialization of
our specific formulations. Our future capital requirements will depend on many factors, including:



| |  |  | progress with our preclinical studies and toxicity studies;
| | - |  | -----------------------------------------------------------



| |  |  | the time and costs involved in obtaining regulatory approvals for the marketing of any of our specific formulations;
| | - |  | --------------------------------------------------------------------------------------------------------------------



| |  |  | the costs of manufacturing any of our specific formulations;
| | - |  | ------------------------------------------------------------



| |  |  | our ability, and the ability of any partner, to effectively market, sell and distribute product, subject to obtaining regulatory approval;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to establish one or more marketing, distribution or other commercialization arrangements
| | - |  | ----------------------------------------------------------------------------------------------------



| |  |  | the cost of any potential licenses or acquisitions; and
| | - |  | -------------------------------------------------------



| |  |  | the costs involved in preparing, filing, prosecuting, maintaining and enforcing patents or defending ourselves against competing technological and market developments.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



You should be aware that:



| |  |  | we may not be able to obtain additional financial resources in the necessary time frame or on terms favorable to us, if at all;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------



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| |  |  | any available additional financing may not be adequate; and
| | - |  | -----------------------------------------------------------



| |  |  | we may be required to use a portion of future financing to repay indebtedness to future creditors.
| | - |  | --------------------------------------------------------------------------------------------------



If adequate funds are not available, we may have to delay, scale back or eliminate one or more of our development programs,
or obtain funds by entering into more arrangements with collaborative partners or others that may require us to relinquish rights to certain of our specific formulations or technologies that we would not otherwise relinquish.



In the event we are unable to obtain additional financing on acceptable
terms, we may not have the financial resources to continue research and development of any of our other proprietary formulations and we could be forced to curtail or cease our operations.



We may be unable to obtain regulatory clearance to market our proprietary formulations in the United States or foreign countries on a
timely basis, or at all.



Our proprietary formulations are
subject to extensive government regulations related to development, clinical trials, manufacturing and commercialization. The process of obtaining FDA and other regulatory approvals is costly, time consuming, uncertain and subject to unanticipated
delays. The FDA may refuse to approve an application for approval of a specific formulation if it believes that applicable regulatory criteria are not satisfied. The FDA may also require additional testing for safety and efficacy. Moreover, if the
FDA grants regulatory approval of a product, the approval may be limited to specific indications or limited with respect to its distribution, which could limit our revenues. Foreign regulatory authorities may apply similar limitations or may refuse
to grant any approval.



No diabetes product using our
technologies has been approved for marketing. Consequently there is no precedent for the successful commercialization of products based on our technologies. In addition, members of our management team have had only limited experience in filing and
pursuing applications necessary to gain regulatory approvals for pharmaceutical products. This may impede our ability to obtain timely approvals from the FDA or foreign regulatory agencies. We will not be able to commercialize our proprietary
products until we obtain regulatory approval, and consequently any delay in obtaining, or inability to obtain regulatory approvals could harm our business.



If we violate regulatory requirements at any stage, whether before or after marketing approval is obtained, we may be fined, forced to remove a product
from the market or experience other adverse consequences, including delay, which would materially harm our financial results. Additionally, we may not be able to obtain the labeling claims necessary or desirable for product promotion.



Moreover, manufacturing facilities operated by the third-party manufacturers
with whom we may contract to manufacture our proprietary formulations may not pass an FDA or other regulatory authority pre-approval inspection. Any failure or delay in obtaining these approvals could prohibit or delay us or any of our business
partners from marketing our formulations.



On August 27,
1998, Diabetes Pro Health, a predecessor entity, received a warning letter from the United States Department of Health and Human Services. The warning letter was written in reference to our marketing and distribution of the products Diabetes Pro
Health, DPH and Pro Health Pak for use as a dietary supplement. The Department of Health & Human Service concluded that the labeling associated with the product made therapeutic claims which caused the product to be considered a drug



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requiring prior approval by the FDA prior to commercialization. Diabetes Pro Health, working with the FDA, modified the labeling in order to be in compliance
with the Dietary Supplement Health and Education Act, or DSHEA, and implementing regulations.



Delays in the conduct or completion of our clinical trials, the analysis of the data from our clinical trials, or our manufacturing scale-up activities may result in delays in our planned filings for regulatory
approvals, and may adversely affect our ability to enter into new collaborative arrangements.



We cannot predict whether we will encounter problems with any of our completed, or planned clinical studies that will cause us or regulatory authorities
to delay or suspend planned clinical studies. If the results of our planned clinical studies for our proprietary formulations are not available when we expect or if we encounter any delay in the analysis of data from our clinical studies or if we
encounter delays in our ability to scale-up our manufacturing processes, we may have to delay our planned filings seeking regulatory approval of our proprietary formulations. Additionally we may not have the financial resources to continue research
and development of any of our proprietary formulations; and we may not be able to enter into additional collaborative arrangements relating to any proprietary formulations subject to delay in clinical studies or delay in regulatory filings.



Any of the following could delay the completion of our planned
clinical studies:



| |  |  | failure of the FDA or comparable foreign authorities to approve the scope or design of our clinical trials;
| | - |  | -----------------------------------------------------------------------------------------------------------



| |  |  | delays in enrolling volunteers;
| | - |  | -------------------------------



| |  |  | insufficient supply or deficient quality of specific formulation materials or other materials necessary for the performance of clinical trials;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | negative results of clinical studies; or
| | - |  | ----------------------------------------



| |  |  | serious side effects experienced by study participants relating to a specific formulation.
| | - |  | ------------------------------------------------------------------------------------------



Even if we obtain approval to commercialize our proprietary products, we will be subject to continuing regulatory
requirements. If we or our business partners are able to obtain regulatory approval for our proprietary products in the United States or other countries, the approvals will be subject to continual review, and newly discovered or developed safety
issues may result in revocation of the regulatory approvals. Moreover, if we obtain marketing approval in the United States, the marketing of the product will be subject to extensive regulatory requirements administered by the FDA and other
regulatory bodies, including adverse event reporting requirements and the FDAs general prohibition against promoting products for unapproved uses. The manufacturing facilities for our products are also subject to continual review and periodic
inspection and approval of manufacturing modifications. Domestic manufacturing facilities are subject to inspections by the FDA and must comply with the FDAs current Good Manufacturing Practices (cGMP) regulations. The FDA stringently applies
regulatory standards for manufacturing. In complying with these regulations, manufacturers must spend funds, time and effort in the areas of production, record keeping, personnel and quality control to ensure full technical compliance. Failure to
comply with any of these post-approval requirements can, among other things, result in warning letters, product seizures, recalls, fines, injunctions, suspensions or revocations of marketing licenses, operating restrictions and criminal



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prosecutions. Any of these enforcement actions or any unanticipated changes in existing regulatory requirements or the adoption of new requirements could
adversely affect our ability to market products and generate revenues and thus adversely affect our ability to continue our business.



The manufacturers of our product candidates also are subject to numerous federal, state and local laws relating to such matters as safe working
conditions, manufacturing practices, environmental protection, fire hazard control and hazardous substance disposal. In the future, our manufacturers may incur significant costs to comply with those laws and regulations, which could increase our
manufacturing costs and reduce our ability to operate profitably.



We have
not commenced FDA trials and may not ever commence FDA trials.



We have not commenced FDA trials of any of our prescription formulations. There are a number of requirements that we must satisfy in order to begin FDA trials. These requirements will require substantial time, effort and financial
resources. There can be no assurance that we will complete the steps necessary to reach FDA trials.



Our ability to enter into third-party relationships is important to our successful development and commercialization of our specific formulations and our
potential profitability.



To market any of our products in the
United States or elsewhere, we must develop internally or obtain access to sales and marketing forces with technical expertise and with supporting distribution capability in the relevant geographic territory.



We may not be able to enter into marketing and distribution arrangements or
find a corporate partner for our specific formulation or our other specific formulations, and we are not likely to be able to market and distribute our products ourselves. If we are not able to enter into a marketing or distribution arrangement or
find a corporate partner who can provide support for commercialization of our specific formulations as we deem necessary, we may not be able to commercialize our products successfully. Moreover, any new marketer or distributor or corporate partner
for our specific formulations, with whom we choose to contract may not establish adequate sales and distribution capabilities or gain market acceptance for our products, if any.



Our ability to generate revenues will be diminished if we fail to obtain acceptable prices or an adequate level of reimbursement for our
products from third-party payors.



The requirements
governing product licensing, pricing and reimbursement vary widely from country to country. Some countries require approval of the sale price of a drug before it can be marketed. In many countries, the pricing review period begins after product
licensing approval is granted. As a result, we may obtain regulatory approval for a product in a particular country, but then be subject to price regulations that reduce our revenues from the sale of the product. Also, in some foreign markets,
pricing of prescription pharmaceuticals is subject to continuing governmental control even after initial marketing approval. If we succeed in bringing a specific formulation to market, we cannot be certain that the products will be considered cost
effective and that reimbursement will be available or, if available, will be sufficient to allow us to sell the products on a competitive basis.



The continuing efforts of government and third-party payors to contain or reduce the costs of healthcare through various means, including efforts to
increase the amount of patient co-pay obligations, may limit our commercial opportunity. For example, in some foreign markets, pricing and



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profitability of prescription pharmaceuticals are subject to government control. In the United States, we expect that there will continue to be a number of
federal and state proposals to implement similar government control. In addition, increasing emphasis on managed care in the United States will continue to put pressure on the rate of adoption and pricing of pharmaceutical products. Cost control
initiatives could decrease the price that any of our collaborators or we would receive for any products in the future. Further, cost control initiatives could adversely affect our collaborators ability to commercialize our products, our
ability to realize revenues from this commercialization, and our ability to fund the development of future specific formulations.



Our ability to commercialize pharmaceutical products, alone or with collaborators, may depend in part on the extent to which adequate reimbursement for
the products will be available from governmental and health administration authorities, private health insurers, and other third-party payors.



Significant uncertainty exists as to the reimbursement status of newly approved health care products. Third-party payors, including Medicare, are
challenging the prices charged for medical products and services. Government and other third-party payors increasingly are attempting to contain health care costs by limiting both coverage and the level of reimbursement for new drugs and by
refusing, in some cases, to provide coverage for uses of approved products for disease indications for which the FDA has not granted labeling approval. Third-party insurance coverage may not be available to patients for any products we discover and
develop, alone or with collaborators. If government and other third-party payors do not provide adequate coverage and reimbursement levels for our products, the market acceptance of these products may be reduced.



We do not manufacture our own specific formulations and rely on third-party manufacturers
to provide the components necessary for our specific formulations.



We do not manufacture our own specific formulations and may not be able to obtain adequate supplies, which could cause delays or reduce profit margins. The manufacturing of sufficient quantities of new specific formulations is a
time-consuming and complex process. We have no manufacturing capabilities. In order to continue to develop our proprietary formulations, apply for regulatory approvals and ultimately commercialize additional products, we need to contract or
otherwise arrange for the necessary manufacturing.



If any of
our existing or future manufacturers cease to manufacture or are otherwise unable to deliver any of the components of our specific formulations in either bulk or dosage form, or other product components, we may need to engage additional
manufacturers. The cost and time to establish manufacturing facilities would be substantial. As a result, using a new manufacturer could disrupt our ability to supply our products and/or reduce our profit margins. Any delay or disruption in the
manufacturing of bulk product, the dosage form of our products or other product components, including pens for delivery of our products, could harm our ability to generate product sales, harm our reputation and require us to raise additional funds.



We have not selected any third-party contract manufacturers for our
proprietary formulations.



We have not yet selected
manufacturers for our proprietary formulations and we cannot be certain that we will be able to obtain long-term supplies of those materials on acceptable terms. We do not currently have established quality control and quality assurance programs,
including a set of standard



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operating procedures, analytical methods and specifications, designed to ensure that proprietary formulations are manufactured in accordance with current
good manufacturing practices and other domestic and foreign regulations.



If
our patents are determined to be unenforceable or if we are unable to obtain new patents based on current patent applications or for future inventions, we may not be able to prevent others from using our intellectual property.



Our success will depend in part on our ability to obtain and expand patent
protection for our specific formulations and technologies both in the United States and other countries. We cannot guarantee that any patents will issue from any pending or future patent applications owned by or licensed to us. Alternatively, a
third party may successfully circumvent our patents. Our rights under any issued patents may not provide us with sufficient protection against competitive products or otherwise cover commercially valuable products or processes. In addition, because
patent applications in the United States are maintained in secrecy for eighteen months after the filing of the applications, and publication of discoveries in the scientific or patent literature often lag behind actual discoveries, we cannot be sure
that the inventors of subject matter covered by our patents and patent applications were the first to invent or the first to file patent applications for these inventions. In the event that a third party has also filed a patent on a similar
invention, we may have to participate in interference proceedings declared by the U.S. Patent and Trademark Office to determine priority of invention, which could result in a loss of our patent position. Furthermore, we may not have identified all
U.S. and foreign patents that pose a risk of infringement.



Litigation
regarding patents and other proprietary rights may be expensive, cause delays in bringing products to market and harm our ability to operate.



Our success will depend in part on our ability to operate without infringing the proprietary rights of third parties. Legal standards relating to the
validity of patents covering pharmaceutical and biotechnological inventions and the scope of claims made under these patents are still developing. As a result, our ability to obtain and enforce patents is uncertain and involves complex legal and
factual questions. Third parties may challenge or infringe upon existing or future patents. In the event that a third party challenges a patent, a court may invalidate the patent or determine that the patent is not enforceable. Proceedings involving
our patents or patent applications or those of others could result in adverse decisions about:



| |  |  | the patentability of our inventions and products relating to our specific formulations; and/or
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | the enforceability, validity or scope of protection offered by our patents relating to our specific formulations.
| | - |  | -----------------------------------------------------------------------------------------------------------------



The use of our technologies could potentially conflict with the rights of others.



The manufacture, use or sale of any of our proprietary
formulations may infringe on the patent rights of others. If we are unable to avoid infringement of the patent rights of others, we may be required to seek a license, defend an infringement action or challenge the validity of the patents in court.
Patent litigation is costly and time consuming. We may not have sufficient resources to bring these actions to a successful conclusion. In such case, we may be required to alter our products, pay licensing fees or cease activities. If our products
conflict with patent rights of others, third parties could bring legal actions against us claiming damages and seeking to enjoin manufacturing and marketing of



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the affected products. If these legal actions are successful, in addition to any potential liability for damages, we could be required to obtain a license in
order to continue to manufacture or market the affected products. We may not prevail in any legal action and a required license under the patent may not be available on acceptable terms.



We may be unable to adequately prevent disclosure of trade secrets and other proprietary information.



In order to protect our proprietary technology and processes, we rely in part
on confidentiality agreements with our corporate partners, employees, consultants, outside scientific collaborators and sponsored researchers and other advisors. These agreements may not effectively prevent disclosure of confidential information and
may not provide an adequate remedy in the event of unauthorized disclosure of confidential information. In addition, others may independently discover trade secrets and proprietary information. Costly and time-consuming litigation could be necessary
to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain trade secret protection could adversely affect our competitive business position.



Competition in the biotechnology and pharmaceutical industries may result in competing products, superior marketing of other products and
lower revenues or profits for us.



There are many companies
that are seeking to develop products and therapies for the treatment of diabetes and other metabolic disorders. Our competitors include multinational pharmaceutical and chemical companies, specialized biotechnology firms and universities and other
research institutions. A number of our largest competitors, including Bristol-Myers Squibb Company, Aventis, Eli Lilly and Company, GlaxoSmithKline, Merck & Co., Novartis, Novo Nordisk and Takeda Pharmaceuticals, are pursuing the
development or marketing of pharmaceuticals that target the same diseases that we are targeting, and it is possible that the number of companies seeking to develop products and therapies for the treatment of diabetes and other metabolic disorders
will increase. The government, through the National Center for Complementary and Alternative Medicine (NCCAM) funds a variety of private, and for-profit, and academic groups to conduct trials on chromium supplementation and related alternative
approaches to treat diabetes.



Many of our competitors have
substantially greater financial, technical, human and other resources than we do. In addition, many of these competitors have significantly greater experience than we do in undertaking preclinical testing and human clinical studies of new
pharmaceutical products and in obtaining regulatory approvals of human therapeutic products. Accordingly, our competitors may succeed in obtaining FDA approval for products more rapidly than we do, which would provide these competitors with an
advantage for the marketing of products with similar potential uses. Furthermore, if we are permitted to commence commercial sales of products, we may also be competing with respect to manufacturing and product distribution efficiency and sales and
marketing capabilities, areas in which we have limited or no experience as an organization.



Our target patient population for our proprietary formulations is people with Type 2 diabetes. Other products are currently in development or exist in the market that may compete directly with the products that
we are seeking to develop and market. Various products are available to treat Type 2 diabetes, including, sulfonyureas, metformin, insulin, glinides, alpha-glucosidase inhibitors, and thiazolidinediones.



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In addition, several companies are developing various approaches to improve treatments for Type 1
and Type 2 diabetes. We cannot predict whether our proprietary formulations, even if successfully tested and developed, will have sufficient advantages over existing products to cause health care professionals to adopt them over other products
or that our specific formulations will offer an economically feasible alternative to existing products.



We may not be able to keep up with the rapid technological change in the biotechnology and pharmaceutical industries, which could make our products obsolete and reduce our revenues.



Biotechnology and related pharmaceutical technologies have undergone and
continue to be subject to rapid and significant change. Our future will depend in large part on our ability to maintain a competitive position with respect to these technologies. Any products that we develop may become obsolete before we recover
expenses incurred in developing those products, which may require that we raise additional funds to continue our operations.



Our future success depends on our ability to retain our chief executive officer and other key executives.



Our success largely depends on the skills, experience and efforts of our key
personnel, including our Chief Executive Officer, Edward B. Wilson. We have entered into a written employment agreement with Mr. Wilson that can be terminated at any time by us or by Mr. Wilson. The loss of Mr. Wilson, or our
failure to retain other key personnel, would jeopardize our ability to execute our strategic plan and materially harm our business.



Our future success depends on our ability to hire additional employees.



We currently have only two employees. If we are unable to hire additional employees, our likelihood of success could decrease significantly.



Our business has a substantial risk of product liability claims, and insurance may be
expensive or unavailable.



Our business exposes us to
potential product liability risks that are inherent in the testing, manufacturing and marketing of human therapeutic products. Product liability claims could result in a recall of products or a change in the indications for which they may be used.



We currently have limited product liability insurance, including clinical
trial insurance, and will seek additional coverage prior to initiating clinical trials and marketing any of our specific formulations.



We cannot assure you that our insurance will provide adequate coverage against potential liabilities. Furthermore, clinical trial and product liability
insurance is becoming increasingly expensive. As a result, we may not be able to maintain current amounts of insurance coverage, obtain additional insurance or obtain insurance at a reasonable cost or in sufficient amounts to protect against losses
that could have a material adverse effect on us.



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Item 2.Properties



We lease in aggregate approximately 1,100 square feet of office space located in La Jolla, California, and Carefree, Arizona pursuant to two leases each on a month-to-month basis. The Arizona lease is sublet from our
CEO at his cost, and the La Jolla office space is sublet from Avalon Ventures. One of our directors, Kevin Kinsella, is a general partner of Avalon, and the Board of Directors has determined that the rent charged to us for both leases is fair and
reasonable. We believe that our facilities are adequate to meet our operating needs for the foreseeable future.



Item 3.Legal Proceedings



We are not a party to any legal proceedings.



Item 4.Submission of Matters to a Vote of Security Holders



There were no matters submitted to a vote of security holders during the fourth quarter of 2005.



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PART II



Item 5.Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities



Our common stock is traded on the O-T-C Bulletin Board Market under the symbol AKES.OB. The following table
presents quarterly information on the price range of high and low sales prices for our common stock for the periods indicated since January 1, 2004. These sales prices reflect the 20 for 1 reverse stock split on May 3, 2004 prior to our
acquisition of Akesis Delaware. (See Item 7.)



|               |  |      |       |     |   |     
|-------------- |  | ---- | ----- | --- | - | ----
|               |  | High |       | Low
|2005           |  |      |       |     |   |     
|First Quarter  |  | $    | 8.75  |     | $ | 4.75
|Second Quarter |  |      | 9.48  |     |   | 5.35
|Third Quarter  |  |      | 9.60  |     |   | 5.40
|Fourth Quarter |  |      | 7.50  |     |   | 1.65
|               |  |     
|2004           |  |      |       |     |   |     
|First Quarter  |  | $    | 3.00  |     | $ | 2.00
|Second Quarter |  |      | 12.00 |     |   | 3.00
|Third Quarter  |  |      | 4.25  |     |   | 1.75
|Fourth Quarter |  |      | 6.25  |     |   | 4.00



As of March 1,
2006, there were approximately 406 stockholders of record of our common stock with approximately 15,272,552 shares outstanding. We have never declared or paid any dividends and do not expect to pay any dividends in the foreseeable future. We did not
repurchase any securities of the Company in the fourth quarter of 2005.



The following table summarizes the securities authorized for issuance under our equity compensation plans as of December 31, 2005.



|                                                              |  |                                                                                       |  |                                                                       |      |                                                                                      |          
|------------------------------------------------------------- |  | ------------------------------------------------------------------------------------- |  | --------------------------------------------------------------------- | ---- | ------------------------------------------------------------------------------------ | ---------
|Plan Category                                                 |  | Number ofSecurities to be Issued UponExercise ofOutstandingOptions,Warrants andRights |  | WeightedAverageExercise Priceof OutstandingOptions,Warrants andRights |      | Number ofSecuritiesRemainingAvailable forFutureIssuance UnderEquityCompensationPlans
|Equity compensation plans approved by stockholders            |  | 400,000                                                                               |  | $                                                                     | 1.94 |                                                                                      | 1,100,000
|Equity compensation arrangements not approved by stockholders |  | 1,062,499                                                                             |  | $                                                                     | 1.50 |                                                                                      |          
|Warrants issued                                               |  | 0                                                                                     |  | $                                                                     | 0    |                                                                                      | 0        
|                                                              |  |                                                                                       |  |                                                                       |      |                                                                                      |          
|Total                                                         |  | 1,462,499                                                                             |  | $                                                                     | 1.62 |                                                                                      | 1,100,000
|                                                              |  |                                                                                       |  |                                                                       |      |                                                                                      |          



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Item 6.Selected Financial Data



The following table shows selected financial data. The selected financial data has been derived from our audited consolidated financial statements for fiscal years 2002 through 2005 and unaudited financial information
for 2001 and is qualified by reference to, and should be read in conjunction with, the Consolidated Financial Statements, and Notes thereto, and Managements Discussion and Analysis of Financial Condition and Results of Operations,
included elsewhere in this report:



|                                                             |  |                          |            |   |      |   |            |      |  |   |           |   |  |      |           |   |  |   |           |  
|------------------------------------------------------------ |  | ------------------------ | ---------- | - | ---- | - | ---------- | ---- |  | - | --------- | - |  | ---- | --------- | - |  | - | --------- | -
|                                                             |  | Years Ended December 31, |           
|                                                             |  | 2005                     |            |   | 2004 |   |            | 2003 |  |   | 2002      |   |  | 2001 |          
|Consolidated Statement of Operations Data:                   |  |                          |            |   |      |   |            |      |  |   |           |   |  |      |           |   |  |   |           |  
|Revenues                                                     |  | $                        |           |   |      | $ |           |      |  | $ | 4,785     |   |  | $    | 26,621    |   |  | $ | 19,512    |  
|Operating expenses                                           |  | $                        | 3,110,246  |   |      | $ | 1,517,691  |      |  | $ | 28,480    |   |  | $    | 152,283   |   |  | $ | 83,009    |  
|Loss from operations                                         |  | $                        | (3,110,246 | ) |      | $ | (1,517,691 | )    |  | $ | (25,397   | ) |  | $    | (130,726  | ) |  | $ | (70,070   | )
|Net loss                                                     |  | $                        | (3,105,826 | ) |      | $ | (1,525,539 | )    |  | $ | (31,291   | ) |  | $    | (132,687  | ) |  | $ | (69,004   | )
|Net loss per common sharebasic and diluted                  |  | $                        | (0.21      | ) |      | $ | (0.24      | )    |  | $ | (0.01     | ) |  | $    | (0.02     | ) |  | $ | (0.01     | )
|Weighted average common shares outstandingbasic and diluted |  |                          | 14,993,031 |   |      |   | 6,341,604  |      |  |   | 5,377,466 |   |  |      | 5,377,466 |   |  |   | 5,377,466 |  
|Consolidated Balance Sheet Data:                             |  |                          |            |   |      |   |            |      |  |   |           |   |  |      |           |   |  |   |           |  
|Cash and cash equivalents                                    |  | $                        | 388,551    |   |      | $ | 1,234,250  |      |  | $ |          |   |  | $    | 1,747     |   |  | $ | 28,889    |  
|Working capital                                              |  | $                        | 320,278    |   |      | $ | 1,267,814  |      |  | $ | (29,621   | ) |  | $    | (20,814   | ) |  | $ | 32,957    |  
|Total assets                                                 |  | $                        | 415,107    |   |      | $ | 1,350,250  |      |  | $ |          |   |  | $    | 5,697     |   |  | $ | 41,293    |  
|Stockholder loan                                             |  | $                        |           |   |      | $ |           |      |  | $ | 92,930    |   |  | $    | 70,716    |   |  | $ |          |  
|Shareholders equity                                         |  | $                        | 337,670    |   |      | $ | 1,267,814  |      |  | $ | (122,551  | ) |  | $    | (91,530   | ) |  | $ | 32,957    |  



|                                                                    |  |                            |            |   |          |   |            |               |  |   |              |   |  |   |            |  
|------------------------------------------------------------------- |  | -------------------------- | ---------- | - | -------- | - | ---------- | ------------- |  | - | ------------ | - |  | - | ---------- | -
|                                                                    |  | Quarters Ended (Unaudited) |           
|Quarterly Statement of Operations Data For 2005:                    |  | March 31,                  |            |   | June 30, |   |            | September 30, |  |   | December 31, |  
|Total revenues                                                      |  | $                          |           |   |          | $ |           |               |  | $ |             |   |  | $ |           |  
|Net loss                                                            |  | $                          | (892,500   | ) |          | $ | (862,088   | )             |  | $ | (777,725     | ) |  | $ | (573,513   | )
|Basic and diluted net loss per share                                |  | $                          | (0.06      | ) |          | $ | (0.06      | )             |  | $ | (0.05        | ) |  | $ | (0.04      | )
|Basic and diluted weighted average number of shares of common stock |  |                            | 14,992,552 |   |          |   | 14,992,552 |               |  |   | 14,992,552   |   |  |   | 14,994,454 |  
|                                                                    | 
|                                                                    |  | Quarters Ended (Unaudited) |           
|Quarterly Statement of Operations Data For 2004:                    |  | March 31,                  |            |   | June 30, |   |            | September 30, |  |   | December 31, |  
|Total revenues                                                      |  | $                          |           |   |          | $ |           |               |  | $ |             |   |  | $ |           |  
|Net loss                                                            |  | $                          | (2,751     | ) |          | $ | (310       | )             |  | $ | (375,149     | ) |  | $ | (1,147,329 | )
|Basic and diluted net loss per share                                |  | $                          | (0.00      | ) |          | $ | (0.00      | )             |  | $ | (0.07        | ) |  | $ | (0.13      | )
|Basic and diluted weighted average number of shares of common stock |  |                            | 5,377,466  |   |          |   | 5,377,466  |               |  |   | 5,629,938    |   |  |   | 8,704,276  |  



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Item 7.Managements Discussion and Analysis of Financial Condition and Results of Operations



This discussion and analysis should be read in conjunction with our audited financial statements and accompanying notes included elsewhere in this report.
Operating results are not necessarily indicative of results that may occur in future periods.



Introduction



Liberty
Mint, Ltd. (Liberty or we or us), a Nevada corporation, was initially incorporated in Nevada on May 26, 1999 as a wholly owned subsidiary of Liberty Mint, Ltd., a Colorado corporation. Liberty Mint, Ltd., a
Colorado corporation, was originally incorporated in the state of Colorado on March 15, 1990 as St. Joseph Corp. VI. In July 1993, the name was changed to Petrosavers International, Inc., in September 1996 the name was changed to Hana
Acquisitions Inc. and on June 9, 1997, the name was changed to Liberty Mint, Ltd. In June of 1997, Liberty acquired a 90% majority interest in Liberty Mint, Inc. (LMI), a Utah corporation. Before the acquisition of LMI, Liberty had
not engaged in any material operations. Then in 1998 Liberty formed a wholly owned subsidiary, Liberty Mint Marketing, Inc., a Utah corporation, which became SCCS, Inc. (SCCS) in 2001. In 1999 Liberty formed another wholly owned
subsidiary, The Great Western Mint, Inc., (GWM) a Utah corporation. On October 8, 1999, Liberty filed articles of merger with the states of Colorado and Nevada, effecting a change of domicile from Colorado to the state of Nevada. On
September 23, 1999, Liberty sold its 90% interest in LMI. On December 31, 2001, Liberty sold SCCS and GWM.



Effective December 9, 2004, pursuant to the Agreement and Plan of Merger and Reorganization, dated as of September 27, 2004, (the Merger
Agreement), among Liberty, Akesis Pharmaceuticals, Inc. (Akesis Delaware) and Ann Arbor Acquisition Corporation, a wholly-owned subsidiary of Liberty (MergerSub), MergerSub merged with and into Akesis Delaware, with
Akesis Delaware as the surviving corporation. Immediately prior to the closing of the merger, all of Akesis Delawares preferred shares were converted into common shares. In connection with the merger, the stockholders of Akesis Delaware
received 3.292327 shares of Liberty common stock for each share of Akesis Delaware common stock that they held (on an as-converted basis).



Akesis Delaware was incorporated on April 27, 1998, for the purpose of marketing an established over-the-counter product for lowering blood glucose
levels in the treatment of diabetes. The product was initially developed and marketed through Diabetes Pro Health, Inc. which was merged into the Company. The product was sold primarily through direct sales to consumers.



Although we acquired Akesis Delaware as a result of the transaction, Akesis
Delaware stockholders held approximately 70% of our common stock following the transaction and our pre-merger stockholders held the remaining 30%. Accordingly, for accounting purposes, the acquisition was a reverse acquisition and Akesis
Delaware was the accounting acquiror. Further, since we discontinued our legacy business in 2001, we were a non-operating public shell with no continuing operations, and no intangible assets associated with us were purchased by Akesis
Delaware. Accordingly, the transaction was accounted for as a recapitalization of Akesis Delaware and recorded based on the fair value of our net tangible assets acquired by Akesis Delaware, with no goodwill or other intangible assets being
recognized. Post-merger there are approximately 15 million shares of common stock outstanding. Effective January 11, 2005, Liberty changed its name to Akesis Pharmaceuticals, Inc. and the trading symbol was changed to AKES.OB.



Since Akesis Delaware is the surviving entity, the Selected
Financial Data in Item 6 above and the Financial Statements and Supplementary Data, elsewhere in this Form 10-K reflect Akesis



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Delawares historical results of operations prior to its acquisition by us. Managements Discussion and Analysis of Financial Condition and Results
of Operations that follows is a discussion and analysis of that financial data. The accounts of Liberty and Akesis Delaware have been consolidated as of December 9, 2004, the effective date of the acquisition.



The following discussion of results of operations, liquidity and capital
resources contains forward-looking statements that involve risks and uncertainties. As described in Part I, our actual results may differ materially from the results discussed in the forward-looking statements. Factors that might cause or
contribute to such differences include those discussed below and in the section entitled Risk Factors of this report.



Major Research and Development Projects



We are an early stage biopharmaceutical company engaged in the discovery, development and commercialization of complementary and alternative therapies for
the treatment of three principal forms of carbohydrate intolerance  Type 2 diabetes, Syndrome X, and impaired glucose tolerance, and their associated complications. We have been granted patents and filed patent applications for a
number of proprietary formulations and combination therapies, including formulations with existing diabetes medications, for use in the treatment of Type 2 diabetes. We intend to use our proprietary formulations to develop prescription
treatments for diabetes and related metabolic disorders. These products are in an early stage of development and no regulatory filings to commercialize our products have yet been made with the United States Food and Drug Administration or any
similar state or foreign authorities. We have completed an initial clinical study of a specific formulation and demonstrated a consistent improvement in glycated hemoglobin levels (A1c), compared to base line, after three months of treatment in a diabetic population. The observed reduction in A1c, (which is an established long-term measure of blood glucose), in this open-label study was in excess of 2% for all treatment groups. This reduction
contemplates an average improvement in excess of 20% in blood glucose parameters in this patient population. This included patients taking the initial product candidate as monotherapy, as well as with concomitant medications. We believe that these
clinical studies may suggest that Akesis formulations show the potential for enhancing currently available oral antidiabetic therapeutic agents. We intend to conduct follow-on feasibility clinical trials with one or more of our formulations
with a goal of confirming and extending the results of our initial clinical studies. We believe that the successful completion of these feasibility trials could lead to partnering opportunities in the pharmaceutical industry. We are not currently in
discussions with the FDA regarding the specific requirements for approval of our products.



The risks and uncertainties associated with completing the development of our products on schedule, or at all, include the following, as well as the other risk factors described in this report:



Our products may not be shown to be safe and efficacious in the clinical
trials;



| |  |  | We may be unable to obtain regulatory approval of our products or be unable to obtain such approval on a timely basis;
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | We may be unable to recruit enough patients to complete the clinical trials in a timely manner; and
| | - |  | ---------------------------------------------------------------------------------------------------



| |  |  | We may not have adequate funds to complete the development of our products even if we secure the additional amount of capital we have targeted if we have underestimated the cost of
the clinical trials.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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If our products fail to achieve statistically significant results in the clinical trials, or we do not
complete the clinical trials on a timely basis, our operations, financial position and liquidity could be severely impaired, including as follows:



| |  |  | It could make it more difficult for us to consummate partnering opportunities in the pharmaceutical industry, or at all.
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | Our reputation among investors might be harmed, which could make it more difficult for us to obtain equity capital on attractive terms, or at all.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------



Because of the many risks and uncertainties relating to the completion of
clinical trials, consummation of partnering opportunities in the pharmaceutical industry, receipt of marketing approvals and acceptance in the marketplace, we cannot predict the period in which material cash inflows from our products will commence,
if ever.



Results of Operations for the Years Ended December 31, 2005
and 2004



Year Ended December 31, 2005 Compared
with December 31, 2004



Total operating expenses
increased to $3.1 million for the year ended December 31, 2005, from $1.5 million for the same time period in 2004. Total operating expenses for the year ended December 31, 2005 included a non-cash stock-based compensation charge
of approximately $1.8 million compared to $1.1 million for the year ended December 31, 2004. The stock-based compensation charge for the years ended December 31, 2005 and 2004 was determined in accordance with the provisions of
SFAS No. 123(R), and recognized the expense for options to acquire our common stock that was issued to Edward B. Wilson, our CEO, and John T. Hendrick, our CFO in December 2004 and to Kelly Joy, our former VP of Business Development,
and Kevin Sayer, a member of our Board of Directors in December 2005. Additionally, we incurred approximately $448,000 in payroll related expenses during 2005 compared to approximately $32,000 during 2004 since we did not have any employees during
2004 prior to the completion of the acquisition in December 2004. During the fourth quarter of 2005, in order to conserve cash, we terminated one employee and reduced the salaries of the remaining three employees to an amount approximating the
minimum wage in the state of California. During the first quarter of 2006 we terminated another employee and as of March 15, 2006, we have two remaining employees whose combined gross salary is $2,400 per month. We also incurred approximately
$456,000 in legal, audit and outside accounting fees, as well as printing and other charges, primarily related to being a publicly traded company during 2005 compared to $159,000 during 2004. Finally, our liability insurance premiums and outside
director fees totaled approximately $198,000 during 2005 and we incurred no costs for those items during 2004. Effective October 1, 2005, we no longer pay fees to our outside directors.



Year Ended December 31, 2004 Compared with December 31, 2003



Total operating expenses increased to
$1.5 million for the year ended December 31, 2004, from $28,480 for the same time period in 2003. Total operating expenses for the year ended December 31, 2004 included a non-cash stock-based compensation charge of approximately
$1.1 million, which was determined in accordance with the provisions of SFAS No. 123(R). The stock-based compensation charge recognized the expense for options to acquire our common stock that was issued to Edward B. Wilson, our CEO,
and John T. Hendrick, our CFO. Both individuals joined us in December 2004 immediately after the acquisition of Akesis Delaware by us. Additionally, we incurred approximately $159,000 in legal and accounting fees during 2004 that were primarily
related to the cost of our initial



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audit, patent legal fees and corporate governance and related disclosure matters. We also compensated two of our directors, Kevin J. Kinsella and
John F. Steel IV, and an outside consultant a total of $166,000 for their efforts on our behalf. The compensation was a non-cash charge for the issuance of a total of 1,366,316 shares of our common stock to those individuals for the
services rendered by them. Finally, after completion of the acquisition in December 2004, we incurred approximately $74,000 in operating expenses for payroll, insurance and other operating expenses.



Liquidity and Capital Resources



We have financed our operations primarily through the sale of equity
securities, stockholder loans and limited revenues from the sale of our over-the-counter products. We invest excess cash in investment securities that will be used to fund future operating costs. Cash, cash equivalents and investment securities
totaled $388,551 at December 31, 2005, compared to $1,234,250 at December 31, 2004. We primarily fund current operations with our existing cash and investments. Cash used in operating activities for 2005 totaled $1,164,190. We had no
revenues or other income sources in 2005 to cover operating expenses, and we do not expect any revenues in the foreseeable future. Cash, cash equivalents and investment securities totaled approximately $400,000 at February 28, 2006, and we have
no long-term financial commitments. In addition, our salaries and other operating expenses have been significantly reduced from the levels we incurred during the first nine months of 2005. It is our intention to maintain the low level of operating
expenses until such time as the Company raises additional capital and/or forms a strategic partnership with a corporate partner for the development and commercialization of our products. Therefore, our current cash resources should enable us to
continue operations based on our current level of commitments into the first half of 2007.



On December 30, 2005, we entered into a Common Stock and Warrant Purchase Agreement with certain accredited investors and consummated the initial closing thereunder where we sold 175,000 shares of our common
stock at a purchase price of $2.00 per share. In addition, we issued warrants to the investors to purchase up to 87,500 shares of our common stock in connection with the financing. The warrants are exercisable for shares of our common stock for
three years from the date of the initial closing at an exercise price per share of $3.00. Our net proceeds from the financing after cash expenses related to the financing were $340,075. All the shares and warrants issued in connection with the
financing were exempt from registration by virtue of Section 4(2) of the Securities Act of 1933, as amended.



During the first quarter of 2006, we sold an additional 105,000 shares of our common stock at a purchase price of $2.00 per share to certain accredited
investors in connection with the December 30, 2005 Common Stock and Warrant Purchase Agreement described in the preceding paragraph. In addition, we issued to those investors warrants to purchase up to 52,500 shares of our common stock in
connection with the financing. The warrants are exercisable for shares of our common stock for three years from the date of the initial closing at an exercise price per share of $3.00. Our net proceeds in connection with these additional sales after
cash expenses related to the financing were approximately $201,000. All the shares and warrants issued in connection with the financing were exempt from registration by virtue of Section 4(2) of the Securities Act of 1933, as amended.



In connection with the Common Stock and Warrant Purchase
Agreement described in the preceding paragraphs, the Company paid its placement agents (a) a cash fee equal to one percent (1%) of all funds invested by investors introduced by such finders (excluding amounts paid by investors upon
exercise of warrants), and (b) warrants to purchase up to 30,800 shares of common stock.



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In order to finance additional feasibility trials to further validate our products, we will need to raise
a significant amount of capital. We will also need to raise additional capital to finance our future operating cash needs. We may seek to raise capital through the sale of equity or debt securities or the development of other funding mechanisms. In
addition, we may seek to form a strategic partnership for the development and commercialization of our products.



We believe that minimum proceeds of $3.2 million of additional capital will be required to enable us to fund at least one clinical feasibility study
as well as all of our general and administrative expenses for approximately the next twelve to eighteen months. Each additional clinical study will cost us approximately $1.5 million and if as much as $6.4 million of proceeds in additional
capital are realized, then we anticipate conducting a total of three clinical studies over the next 18 months.



If we are successful in raising additional capital, the first clinical feasibility study that we intend to initiate with the proceeds from this private
placement is related to our metformin combination product. If we realize sufficient proceeds from future sources of capital, then we also plan to conduct clinical studies related to our sulfonyurea combination product and our thalidazione
combination product.



Our actual capital requirements will
depend upon numerous factors, including:



| |  |  | the rate of progress and costs of our clinical trial and research and development activities;
| | - |  | ---------------------------------------------------------------------------------------------



| |  |  | actions taken by the FDA and other regulatory authorities;
| | - |  | ----------------------------------------------------------



| |  |  | the timing and amount of milestone or other payments we might receive from potential strategic partners;
| | - |  | --------------------------------------------------------------------------------------------------------



| |  |  | our degree of success in commercializing our product candidates;
| | - |  | ----------------------------------------------------------------



| |  |  | the emergence of competing technologies and products, and other adverse market developments; and
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | the costs of preparing, filing, prosecuting, maintaining and enforcing patent claims and other intellectual property rights.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



There can be no assurance that we will be able to obtain needed additional
capital or enter into relationships with corporate partners on a timely basis, on favorable terms, or at all. Conditions in the capital markets in general, and the life science capital market specifically, may affect our potential financing sources
and opportunities for strategic partnering.



Critical Accounting Policies



Basis of Revenue Recognition: To date, we do not
have any significant ongoing revenue sources.



Stock-based
compensation: We have adopted SFAS No. 123(R), Accounting for Share-Based Compensation, effective in 2004. Stock-based compensation for 2005 and 2004 was approximately $1.8 million and $1.1 million, respectively.



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Effect of new accounting standards



In March 2005, the FASB issued FIN 47, Accounting for Conditional Asset Retirement Obligations. FIN 47
clarifies that an entity must record a liability for a conditional asset retirement obligation if the fair value of the obligation can be reasonably estimated. The provision is effective no later than the end of fiscal years ending after
December 15, 2005. We do not expect FIN 47 to affect our financial condition or results of operations.



In May 2005, the FASB issued SFAS 154, Accounting Changes and Error Corrections. SFAS 154 establishes retrospective application as
the required method for reporting a change in accounting principle in the absence of explicit transition requirements specific to the newly adopted accounting principle. SFAS 154 also provides guidance for determining whether retrospective
application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS 154 is effective for accounting changes and corrections of errors made in fiscal years beginning
after December 15, 2005. We do not expect the adoption of SFAS 154 to significantly affect our financial condition or results of operations.



In June 2005, the FASB ratified the consensus reached by the Task Force in EITF 05-6. The Task Force reached a consensus that leasehold improvements
that are placed in service significantly after, and not contemplated at or near the beginning of, the lease term should be amortized over the shorter of the useful life of the assets or a term that includes required lease periods and renewals that
are deemed to be reasonably assured at the date of the leasehold improvements are purchased. In addition, leasehold improvements acquired in a business combination should be amortized over the shorter of the useful lives of the assets or a term that
includes required lease periods and renewals that are deemed to be reasonably assured at the date of acquisition. EITF 05-6 is effective for leasehold improvements (within the scope of this issue) that are purchased or acquired in the reporting
period beginning after June 29, 2005. Adoption of EITF 05-6 did not affect our financial condition or results of operations.



Item 7A.Quantitative and Qualitative Disclosures About Market Risk



We do not use derivative financial instruments for trading or speculative purposes. However, we regularly invest excess cash in short-term investments
that are subject to changes in short-term interest rates. We believe that the market risk arising from holding these financial instruments is minimal.



Because we have minimal debt, our exposure to market risks associated with changes in interest rates arise from increases or decreases in interest income
earned on our investment portfolio. We attempt to ensure the safety and preservation of invested funds by limiting default risks, market risk, and reinvestment risk. We mitigate default risk by investing in short-term investments. A hypothetical 100
basis point decrease in interest rates along the entire interest rate yield curve would not materially affect the fair value of our interest sensitive financial instruments at December 31, 2005.



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Item 8.Financial Statements and Supplementary Data



AKESIS PHARMACEUTICALS, INC.

(A Development Stage Company)



INDEX TO FINANCIAL STATEMENTS





|                                                        |  |     
|------------------------------------------------------- |  | ----
|                                                        |  | Page
|Report of Independent Registered Public Accounting Firm |  | 33  
|Consolidated Balance Sheets                             |  | 34  
|Consolidated Statements of Operations                   |  | 35  
|Consolidated Statements of Stockholders Equity         |  | 36  
|Consolidated Statements of Cash Flows                   |  | 37  
|Notes to Consolidated Financial Statements              |  | 38  



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REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM



To the Board of Directors and Stockholders

Akesis Pharmaceuticals, Inc.



We have audited
the accompanying consolidated balance sheets of Akesis Pharmaceuticals, Inc., a Delaware corporation and a development stage company, as of December 31, 2005 and 2004 and the related consolidated statements of operations, stockholders equity,
and cash flows for each of the three years in the period ended December 31, 2005, and the period from April 27, 1998 (date of inception of Akesis Pharmaceuticals, Inc., a Delaware corporation) to December 31, 2005. These consolidated financial
statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these consolidated financial statements based on our audits.



We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards
require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the
financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable
basis for our opinion.



In our opinion, the consolidated financial statements
referred to above present fairly, in all material respects, the consolidated financial position of the Company as of December 31, 2005 and 2004 and the results of its operations and its cash flows for each of the three years in the period ended
December 31, 2005 and the period from April 27, 1998 (date of inception of Akesis Pharmaceuticals, Inc., a Delaware corporation) to December 31, 2005, in conformity with United States generally accepted accounting principles.



SWENSON ADVISORS, LLP

Independent Registered Public Accounting Firm



San Diego, California

March 24, 2006





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Akesis Pharmaceuticals, Inc.

(a Development Stage Company)

Consolidated Balance Sheets

As of December 31, 2005 and 2004



|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | ---------- | - | ---- | - | ---------- | -
|                                                                                                                                                                  |  | December 31, |           
|                                                                                                                                                                  |  | 2005         |            |   | 2004 |  
|Assets                                                                                                                                                            |  |              |            |   |      |   |            |  
|Current assets:                                                                                                                                                   |  |              |            |   |      |   |            |  
|Cash and cash equivalents                                                                                                                                         |  | $            | 388,551    |   |      | $ | 1,234,250  |  
|Prepaid insurance and other current assets                                                                                                                        |  |              | 9,164      |   |      |   | 116,000    |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total current assets                                                                                                                                              |  |              | 397,715    |   |      |   | 1,350,250  |  
|Property and equipment, net                                                                                                                                       |  |              | 17,392     |   |      |   |           |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total assets                                                                                                                                                      |  | $            | 415,107    |   |      | $ | 1,350,250  |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Liabilities and Stockholders Equity                                                                                                                              |  |              |            |   |      |   |            |  
|Current liabilities:                                                                                                                                              |  |              |            |   |      |   |            |  
|Accounts payable                                                                                                                                                  |  | $            | 77,437     |   |      | $ | 82,436     |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total current liabilities                                                                                                                                         |  |              | 77,437     |   |      |   | 82,436     |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total liabilities                                                                                                                                                 |  |              | 77,437     |   |      |   | 82,436     |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Commitments and contingencies (Note 5)                                                                                                                            |  |              |           |   |      |   |           |  
|Stockholders equity:                                                                                                                                             |  |              |            |   |      |   |            |  
|Convertible preferred stock, $0.001 par value, 10,000,000 shares authorized; and zero shares issued and outstanding as of December 31,
2005 and December 31, 2004 |  |              |           |   |      |   |           |  
|Common stock, $0.001 par value, 20,000,000 shares authorized;                                                                                                     |  |              |            |   |      |   |            |  
|15,167,552 and 14,992,552 shares issued and outstanding at December 31, 2005 and December 31, 2004, respectively                                                  |  |              | 15,168     |   |      |   | 14,993     |  
|Additional paid-in capital                                                                                                                                        |  |              | 6,173,556  |   |      |   | 3,998,049  |  
|Deficit accumulated during the development stage                                                                                                                  |  |              | (5,851,054 | ) |      |   | (2,745,228 | )
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total stockholders equity                                                                                                                                        |  |              | 337,670    |   |      |   | 1,267,814  |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  
|Total liabilities and stockholders equity                                                                                                                        |  | $            | 415,107    |   |      | $ | 1,350,250  |  
|                                                                                                                                                                  |  |              |            |   |      |   |            |  



See
accompanying notes.



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Akesis Pharmaceuticals, Inc.

(a Development Stage Company)

Consolidated Statements of Operations

For the Years Ended December 31, 2005, 2004, and 2003 and for the
Cumulative Period from April 27, 1998 (date of inception of Akesis Pharmaceuticals, Inc., a Delaware corporation) to December 31, 2005



|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|-------------------------------------------------------------- |  | ---- | ---------- | - | ---- | - | ---------- | ---- |  | - | ---------------------------------------------------------- | - |  | - | ---------- | -
|                                                               |  | 2005 |            |   | 2004 |   |            | 2003 |  |   | CumulativePeriod fromApril 27, 1998throughDecember 31,2005 |  
|Revenue                                                        |  | $    |           |   |      | $ |           |      |  | $ | 4,785                                                      |   |  | $ | 226,884    |  
|Cost of goods sold                                             |  |      |           |   |      |   |           |      |  |   | 1,702                                                      |   |  |   | 62,314     |  
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Gross margin                                                   |  |      |           |   |      |   |           |      |  |   | 3,083                                                      |   |  |   | 164,570    |  
|Operating costs and expenses:                                  |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Selling, general and administrative                            |  |      | 3,110,246  |   |      |   | 1,517,691  |      |  |   | 28,480                                                     |   |  |   | 5,755,929  |  
|Research and development                                       |  |      |           |   |      |   |           |      |  |   |                                                           |   |  |   | 256,944    |  
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Total expenses                                                 |  |      | 3,110,246  |   |      |   | 1,517,691  |      |  |   | 28,480                                                     |   |  |   | 6,012,873  |  
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Loss from operations                                           |  |      | (3,110,246 | ) |      |   | (1,517,691 | )    |  |   | (25,397                                                    | ) |  |   | (5,848,303 | )
|Interest income/(expense), net                                 |  |      | 7,620      |   |      |   | (6,248     | )    |  |   | (5,894                                                     | ) |  |   | 11,866     |  
|Other expense, net                                             |  |      |           |   |      |   |           |      |  |   |                                                           |   |  |   | (9,817     | )
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Loss before income taxes                                       |  |      | (3,102,626 | ) |      |   | (1,523,939 | )    |  |   | (31,291                                                    | ) |  |   | (5,846,254 | )
|Provision for income taxes                                     |  |      | 3,200      |   |      |   | 1,600      |      |  |   |                                                           |   |  |   | 4,800      |  
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Net loss                                                       |  | $    | (3,105,826 | ) |      | $ | (1,525,539 | )    |  | $ | (31,291                                                    | ) |  | $ | (5,851,054 | )
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Net loss per common share  basic and diluted                  |  | $    | (0.21      | ) |      | $ | (0.24      | )    |  | $ | (0.01                                                      | ) |  | $ | (0.89      | )
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  
|Weighted-average common shares outstanding  basic and diluted |  |      | 14,993,031 |   |      |   | 6,341,604  |      |  |   | 5,377,466                                                  |   |  |   | 6,540,306  |  
|                                                               |  |      |            |   |      |   |            |      |  |   |                                                            |   |  |   |            |  



See
accompanying notes.



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Akesis Pharmaceuticals, Inc.

(a Development Stage Company)

Consolidated Statements of Stockholders Equity

For the Years Ended December 31, 2005, 2004, and 2003,
and For the Cumulative Period from

April 27, 1998 (date of inception of Akesis Pharmaceuticals, Inc., a Delaware corporation) to
December 31, 2005



|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|----------------------------------------------- |  | --------------------------- | - |  | ------------ | ---- | ------------------------ | -------- | -------------------------------------------- | - | ------ | - | ---- | ------ |  | -------- | ------ |  | - | ------ | - | ------ | ---------- |  | - | ------ |  | - | --------- |  | - | ---------- | -
|                                                |  | Convertible Preferred Stock |   |  | Common Stock |      | AdditionalPaid-InCapital |          | DeficitAccumulatedDuring theDevelopmentStage |  
|                                                |  | Series A                    |   |  | Series B     |      |                          | Series C |                                              |   |        |  
|                                                |  | Shares                      |   |  | Amount       |      |                          | Shares   |                                              |   | Amount |   |      | Shares |  |          | Amount |  |   | Shares |   | Amount |            | 
|Balance at April 27, 1998                       |  |                            |   |  | $            |     |                          |          |                                             |   |        | $ |     |        |  |         |        |  | $ |       |   |        |           |  | $ |       |  | $ |          |  | $ |           |  
|Issuance of preferred stock  series A          |  | 404,444                     |   |  |              | 404  |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 227,096   |  |   |           |  
|Issuance of preferred stock  series B          |  |                            |   |  |              |     |                          |          | 135,217                                      |   |        |   | 135  |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 583,476   |  |   |           |  
|Issuance of common stock                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 3,777,030  |  |   | 1,147  |  |   | 2,495     |  |   |           |  
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 4,877     |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (353,806   | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 1998                    |  | 404,444                     |   |  |              | 404  |                          |          | 135,217                                      |   |        |   | 135  |        |  |         |        |  |   |       |   |        | 3,777,030  |  |   | 1,147  |  |   | 817,944   |  |   | (353,806   | )
|Issuance of preferred stock  series B          |  |                            |   |  |              |     |                          |          | 13,205                                       |   |        |   | 13   |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 91,665    |  |   |           |  
|Issuance of common stock                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 1,600,436  |  |   | 486    |  |   | 7,485     |  |   |           |  
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 35,743    |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (519,722   | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 1999                    |  | 404,444                     |   |  |              | 404  |                          |          | 148,422                                      |   |        |   | 148  |        |  |         |        |  |   |       |   |        | 5,377,466  |  |   | 1,633  |  |   | 952,837   |  |   | (873,528   | )
|Issuance of preferred stock  series B          |  |                            |   |  |              |     |                          |          | 17,600                                       |   |        |   | 18   |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 87,982    |  |   |           |  
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 37,990    |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (113,179   | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2000                    |  | 404,444                     |   |  |              | 404  |                          |          | 166,022                                      |   |        |   | 166  |        |  |         |        |  |   |       |   |        | 5,377,466  |  |   | 1,633  |  |   | 1,078,809 |  |   | (986,707   | )
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 7,655     |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (69,004    | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2001                    |  | 404,444                     |   |  |              | 404  |                          |          | 166,022                                      |   |        |   | 166  |        |  |         |        |  |   |       |   |        | 5,377,466  |  |   | 1,633  |  |   | 1,086,464 |  |   | (1,055,711 | )
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 8,201     |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (132,687   | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2002                    |  | 404,444                     |   |  |              | 404  |                          |          | 166,022                                      |   |        |   | 166  |        |  |         |        |  |   |       |   |        | 5,377,466  |  |   | 1,633  |  |   | 1,094,665 |  |   | (1,188,398 | )
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 270       |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (31,291    | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2003                    |  | 404,444                     |   |  |              | 404  |                          |          | 166,022                                      |   |        |   | 166  |        |  |         |        |  |   |       |   |        | 5,377,466  |  |   | 1,633  |  |   | 1,094,935 |  |   | (1,219,689 | )
|Issuance of preferred stock  series C          |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  | 288,653  |        |  |   | 289    |   |        |           |  |   |       |  |   | 129,326   |  |   |           |  
|Issuance of common stock                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 1,366,316  |  |   | 415    |  |   | 165,585   |  |   |           |  
|Conversion of preferred stock  series A        |  | (404,444                    | ) |  |              | (404 | )                        |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 1,331,562  |  |   | 404    |  |   |          |  |   |           |  
|Conversion of preferred stock  series B        |  |                            |   |  |              |     |                          |          | (166,022                                     | ) |        |   | (166 | )      |  |         |        |  |   |       |   |        | 546,599    |  |   | 166    |  |   |          |  |   |           |  
|Conversion of preferred stock  series C        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  | (288,653 | )      |  |   | (289   | ) |        | 950,340    |  |   | 289    |  |   |          |  |   |           |  
|Exercise of stock options                       |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 927,702    |  |   | 282    |  |   | 134,072   |  |   |           |  
|Merger with Liberty Mint, Ltd.                  |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 4,492,567  |  |   | 11,804 |  |   | 1,386,631 |  |   |           |  
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   | 1,087,500 |  |   |           |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |           |  |   |       |  |   |          |  |   | (1,525,539 | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2004                    |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 14,992,552 |  |   | 14,993 |  |   | 3,998,049 |  |   | (2,745,228 | )
|Issuance of common stock                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        | 175,000    |  |   | 175    |  |   | 339,900   |  |   |            |  
|Issuance of warrants for private placement fees |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |            |  |   |        |  |   | 31,607    |  |   |            |  
|Stock-based compensation                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |            |  |   |        |  |   | 1,804,000 |  |   |            |  
|Net loss                                        |  |                            |   |  |              |     |                          |          |                                             |   |        |   |     |        |  |         |        |  |   |       |   |        |            |  |   |        |  |   |           |  |   | (3,105,826 | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  
|Balance at December 31, 2005                    |  |                            |   |  | $            |     |                          |          |                                             |   |        | $ |     |        |  |         |        |  | $ |       |   |        | 15,167,552 |  | $ | 15,168 |  | $ | 6,173,556 |  | $ | (5,851,054 | )
|                                                |  |                             |   |  |              |      |                          |          |                                              |   |        |   |      |        |  |          |        |  |   |        |   |        |            |  |   |        |  |   |           |  |   |            |  



See accompanying notes.



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##### Table of Contents

Akesis Pharmaceuticals, Inc.

(a Development Stage Company)

Consolidated Statements of Cash Flows

For the Years Ended December 31, 2005, 2004, and 2003, and

For the Cumulative Period from April 27, 1998 (date of inception of Akesis Pharmaceuticals,

Inc., a Delaware corporation) to December 31, 2005



|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|--------------------------------------------------------------------------- |  | ----------------------- | ---------- | - | ------------------------------------------------------ | - | ---------- | ---- |  | - | ------- | - |  | - | ---------- | -
|                                                                            |  | Year Ended December 31, |            |   | CumulativePeriod fromApril 27, 1998ThroughDecember 31, |  
|                                                                            |  | 2005                    |            |   | 2004                                                   |   |            | 2003 |  |   | 2005    |  
|Cash flows from operating activities:                                       |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Net loss                                                                    |  | $                       | (3,105,826 | ) |                                                        | $ | (1,525,539 | )    |  | $ | (31,291 | ) |  | $ | (5,851,054 | )
|Adjustments to reconcile net loss to net cash used in operating activities: |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Depreciation and amortization                                               |  |                         | 4,192      |   |                                                        |   |           |      |  |   |        |   |  |   | 11,690     |  
|Stock-based compensation                                                    |  |                         | 1,804,000  |   |                                                        |   | 1,087,500  |      |  |   | 270     |   |  |   | 2,986,236  |  
|Warrants issued for private placement fees                                  |  |                         | 31,607     |   |                                                        |   |           |      |  |   |        |   |  |   | 31,607     |  
|Changes in assets and liabilities:                                          |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Other current assets                                                        |  |                         | 106,836    |   |                                                        |   | (116,000   | )    |  |   | 3,950   |   |  |   | (9,164     | )
|Other assets                                                                |  |                         |           |   |                                                        |   |           |      |  |   |        |   |  |   | (815       | )
|Accounts payable                                                            |  |                         | (4,999     | ) |                                                        |   | 52,815     |      |  |   | 3,109   |   |  |   | 77,437     |  
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Net cash used in operating activities                                       |  |                         | (1,164,190 | ) |                                                        |   | (501,224   | )    |  |   | (23,962 | ) |  |   | (2,754,063 | )
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Cash flows from investing activities:                                       |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Purchase of property and equipment                                          |  |                         | (21,584    | ) |                                                        |   |           |      |  |   |        |   |  |   | (28,268    | )
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Net cash used in investing activities                                       |  |                         | (21,584    | ) |                                                        |   |           |      |  |   |        |   |  |   | (28,268    | )
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Cash flows from financing activities:                                       |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Proceeds from Series A preferred stock issuances                            |  |                         |           |   |                                                        |   |           |      |  |   |        |   |  |   | 227,500    |  
|Proceeds from Series B preferred stock issuances                            |  |                         |           |   |                                                        |   |           |      |  |   |        |   |  |   | 763,290    |  
|Proceeds from Series C preferred stock issuances                            |  |                         |           |   |                                                        |   | 129,615    |      |  |   |        |   |  |   | 129,615    |  
|Proceeds from common stock issuances                                        |  |                         | 340,075    |   |                                                        |   | 1,698,789  |      |  |   |        |   |  |   | 2,050,477  |  
|(Payment of)/ proceeds from shareholders loans                             |  |                         |           |   |                                                        |   | (92,930    | )    |  |   | 22,215  |   |  |   |           |  
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Net cash provided by financing activities                                   |  |                         | 340,075    |   |                                                        |   | 1,735,474  |      |  |   | 22,215  |   |  |   | 3,170,882  |  
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Net increase (decrease) in cash and cash equivalents                        |  |                         | (845,699   | ) |                                                        |   | 1,234,250  |      |  |   | (1,747  | ) |  |   | 388,551    |  
|Cash and cash equivalents at beginning of period                            |  |                         | 1,234,250  |   |                                                        |   |           |      |  |   | 1,747   |   |  |   |           |  
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Cash and cash equivalents at end of period                                  |  | $                       | 388,551    |   |                                                        | $ | 1,234,250  |      |  | $ |        |   |  | $ | 388,551    |  
|                                                                            |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Supplemental Disclosures of Cash Flow Information:                          |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Interest Paid                                                               |  | $                       |           |   |                                                        | $ | 6,248      |      |  | $ | 5,894   |   |  | $ | 14,103     |  
|Income Taxes Paid                                                           |  | $                       | 3,200      |   |                                                        | $ | 1,600      |      |  | $ |        |   |  | $ | 4,800      |  
|Supplemental Disclosures of Non-Cash Investing and Financing Activities:    |  |                         |            |   |                                                        |   |            |      |  |   |         |   |  |   |            |  
|Conversion of shareholders loans to Series C convertible preferred stock   |  | $                       |           |   |                                                        | $ | 129,615    |      |  | $ |        |   |  | $ | 129,615    |  
|Conversion of Series A, B and C convertible preferred stock to common stock |  | $                       |           |   |                                                        | $ | 1,120,404  |      |  | $ |        |   |  | $ | 1,120,404  |  



See accompanying notes.



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Akesis Pharmaceuticals, Inc.

(a Development Stage Company)

Notes to Consolidated Financial Statements

As of December 31, 2005 and 2004, For the Years Ended
December 31, 2005, 2004 and 2003, and For the Cumulative Period from April 27, 1998 (date of inception of Akesis Pharmaceuticals, Inc., a Delaware corporation) to December 31, 2005



|1. | The Company and Recapitalization
|-- | --------------------------------



Liberty Mint, Ltd. (the Company or Liberty), a Nevada corporation, was initially incorporated in Nevada on May 26, 1999 as a
wholly owned subsidiary of Liberty Mint, Ltd., a Colorado corporation. Liberty Mint, Ltd., a Colorado corporation, was originally incorporated in the state of Colorado on March 15, 1990 as St. Joseph Corp. VI. In July 1993, the name was
changed to Petrosavers International, Inc., in September 1996 the name was changed to Hana Acquisitions Inc. and on June 9, 1997, the name was changed to Liberty Mint, Ltd. In June of 1997, Liberty acquired a 90% majority interest in Liberty
Mint, Inc., (LMI) a Utah corporation. Before the acquisition of LMI, Liberty had not engaged in any material operations. In 1998 Liberty formed a wholly owned subsidiary, Liberty Mint Marketing, Inc., a Utah corporation, which became
SCCS, Inc. (SCCS) in 2001. In 1999 Liberty formed another wholly owned subsidiary, The Great Western Mint, Inc., (GWM) a Utah corporation. On October 8, 1999, Liberty filed articles of merger with the states of Colorado
and Nevada, effecting a change of domicile of Liberty to the state of Nevada. On September 23, 1999, Liberty sold its 90% interest in LMI. On December 31, 2001, Liberty sold SCCS and GWM. Effective January 11, 2005, Liberty changed
its name to Akesis Pharmaceuticals, Inc. and the trading symbol was changed to AKES.OB.



Effective December 9, 2004, pursuant to the Agreement and Plan of Merger and Reorganization, dated as of September 27, 2004, (the Merger Agreement), among Liberty, Akesis Pharmaceuticals, Inc.
(Akesis Delaware) and Ann Arbor Acquisition Corporation, a wholly-owned subsidiary of Liberty (MergerSub), MergerSub merged with and into Akesis Delaware, with Akesis Delaware as the surviving corporation. Immediately prior
to the closing of the merger, all of Akesis Delawares preferred shares were converted into common shares. In connection with the merger, the stockholders of Akesis Delaware received 3.292327 shares of Liberty common stock for each share of
Akesis Delaware common stock that they held (on an as-converted basis). All references in the consolidated financial statements, and notes thereto, to number of shares and per share amounts reflect the exchange ratio.



Although Liberty acquired Akesis Delaware as a result of the transaction,
Akesis Delaware stockholders held approximately 70% of Liberty following the transaction. Accordingly, for accounting purposes, the acquisition was a reverse acquisition and Akesis Delaware was the accounting acquiror.
Further, since Liberty discontinued its legacy business in 2001, Liberty was a non-operating public shell with no continuing operations, and no intangible assets associated with Liberty were purchased by Akesis Delaware. Accordingly, the transaction
was accounted for as a recapitalization of Akesis Delaware and recorded based on the fair value of Libertys net tangible assets acquired by Akesis Delaware. No goodwill or other intangible assets were recorded.



Two of the conditions of closing of the Akesis Delaware acquisition were that
as of the closing, all of Libertys debt would be paid or extinguished, and it would have $1.5 million of unrestricted cash on hand. Costs incurred by Akesis Delaware directly related to the transaction, amounting to



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$101,565, were charged to additional paid-in capital. The conversion of all of Akesis Delaware preferred stock into common stock resulted in an additional
2,828,501 shares of Akesis Delaware common stock outstanding and the merger resulted in the issuance of 10,499,985 Liberty common shares to Akesis Delawares pre-merger shareholders (on an as-converted basis).



On February 14, 2005, the Company filed a Form 8-K with the
Securities and Exchange Commission that presented an unaudited pro forma condensed consolidated balance sheet as of September 30, 2004 as if the acquisition of Akesis Delaware by Liberty had been effective September 30, 2004. Also
presented in the Form 8-K were unaudited pro forma condensed consolidated statements of operations for the nine months ended September 30, 2004 and 2003 and for the year ended December 31, 2003 as if the merger had been effective
January 1, 2003.



Akesis Delaware was incorporated on
April 27, 1998, for the purpose of marketing an established over-the-counter product for lowering blood glucose levels in the treatment of diabetes. The product was initially developed and marketed through Diabetes Pro Health, Inc. which was
merged into the Akesis Delaware. The product was sold primarily through direct sales to consumers.



Akesis Delaware is considered to be in the development stage as defined in Statement of Financial Accounting Standards No. 7, Accounting and
Reporting by Developing Stage Enterprises (SFAS No. 7) and since inception has devoted substantially all of its efforts to developing its products, raising capital and recruiting personnel.



|2. | Summary of Significant Accounting Policies
|-- | ------------------------------------------



Principles of consolidation

The
acquisition of Akesis Delaware by Liberty has been accounted for as a reorganization as described in Note 1. Since Akesis Delaware is the surviving entity, the accompanying consolidated financial statements reflect its historical results of
operations prior to the acquisition. The accounts of Liberty and Akesis Delaware have been consolidated as of December 9, 2004, the effective date of the acquisition.



Use of estimates

The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of
contingent assets and liabilities at the date of the financial statements and the reported amount of expenses during the reporting period. Actual results could differ from those estimates.



Business risk and concentrations of credit risk

Akesis Delawares business is in the healthcare industry and sells products that may not be successful in the marketplace. Financial instruments
which potentially subject the Company to concentrations of credit risk consist of cash and cash equivalents, including money market accounts. Substantially all of our cash and cash equivalents are maintained with one financial institution in the
United States. Deposits held with that financial institution exceed the amount of insurance provided on such deposits. Those deposits may be redeemed upon demand and, therefore, bear minimal risk.



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Fair value of financial instruments

The carrying amounts of cash and cash equivalents, prepaid assets and accounts payable approximate fair market value because of the short maturity of
those instruments.



Cash and cash equivalents

Cash equivalents consist of highly liquid investment with original maturities of three months or less when purchased.



Property and equipment

Property and equipment are stated at cost and depreciated using the straight-line method over the estimated useful lives of the related assets ranging
from 3 to 5 years. Maintenance and repairs are charged to expense as incurred, and improvements and betterments are capitalized. When assets are retired or otherwise disposed of, the cost and accumulated depreciation and amortization are removed
from the accounts and any resulting gain or loss is reflected in operations in the period realized.



Income taxes

Income taxes are
accounted for in accordance with Statement of Financial Accounting Standards No. 109, Accounting for Income Taxes (SFAS No. 109). Under this method, deferred tax assets and liabilities are determined based on the
difference between the financial statement and tax basis of assets and liabilities and net operating loss and credit carryforwards using enacted tax rates in effects for the year in which the differences are expected to reverse. Valuation allowances
are established when necessary to reduce deferred tax assets to the amounts expected to be realized.



Revenue recognition

Akesis Delaware
recognizes product sales upon shipment to the customer and when payment is probable or collected immediately.



Research and development

Research and
development costs are expensed as incurred. Such costs include personnel costs, supplies, and clinical trials.



Stock-based compensation

In December
2004 the FASB issued SFAS No. 123 (revised 2004), Share-Based Payment (SFAS No. 123(R)), which is a revision of SFAS No. 123, Accounting for Stock-Based Compensation (SFAS No. 123).
SFAS No. 123(R) requires all share-based payments to employees, including grants of employee stock options, to be recognized in the financial statements based on their fair values and does not allow the previously permitted pro forma disclosure
as an alternative to financial statement recognition. SFAS No. 123(R) supersedes APB 25 and related interpretations and amends SFAS No. 95, Statement of Cash Flows. SFAS No. 123(R) is required to be effective beginning in the first
quarter of fiscal 2006. However, the Company decided to adopt SFAS No. 123(R) effective with the acquisition of Akesis Delaware by Liberty on December 9, 2004. In March 2005, the Securities and Exchange Commission issued Staff
Accounting Bulletin No. 107 (SAB 107) relating to SFAS No. 123(R), which among other things, expanded the coverage of SFAS No. 123(R) to include share-based payments to outside directors. The Company has applied the
provisions of SAB 107 in its adoption of SFAS No. 123(R).



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Compensation costs for all share-based awards to employees and outside directors are measured based on
the grant date fair value of those awards and is recognized over the period during which the employee or outside director is required to perform service in exchange for the award (generally over the vesting period of the award). The cost of
share-based compensation awards is recognized during the period based on the value of the portion of share-based payment awards that is ultimately expected to vest during the period, and is amortized under the multiple option methodology prescribed
by SFAS No. 123(R). As share-based compensation expense recognized in the consolidated statement of operations for the years ended December 31, 2005 and 2004 is based on awards ultimately expected to vest, it has been reduced for estimated
forfeitures. SFAS No. 123(R) requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.



We have no awards with market or performance conditions. Excess tax benefits,
as defined by SFAS No. 123(R), will be recognized as an addition to additional paid-in capital. The adoption of the SFAS No. 123(R) fair value method resulted in a non-cash stock-based compensation charge of $1,077,000 on the
Companys reported results of operations for the year ended 2004. The non-cash compensation charge for the year ended December 31, 2005 is $1,804,000.



Prior to the adoption of SFAS No. 123(R), no stock options had been issued by Akesis Delaware to employees. However, stock options were issued prior
to the recapitalization to non-employees and were recorded at their fair value in accordance with SFAS No. 123 and EITF 96-18, Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction
with Selling, Goods or Services. Such stock options to non-employees were periodically re-measured as the stock options vested, and no re-measurement issues having a material impact on the financial statements were identified.



Stock offering costs

Expenses incurred in connection with common stock issuances are recorded as an offset to additional paid-in capital on the condensed consolidated balance
sheets. Such expenses consist of third-party related offering expenses.



Comprehensive income (loss)

Comprehensive income (loss) is defined as the change in equity of a business enterprise during
a period from transactions and other events and circumstances from non-owner sources. We present comprehensive loss in our consolidated statements of shareholders equity and comprehensive loss.



Net loss per share

Basic and diluted net loss per share is computed in accordance with Statement of Financial Accounting Standards No. 128, Earnings per
Share. Basic loss per share includes no dilution and is computed by dividing net loss by the weighted-average number of shares of common stock outstanding for the period. Diluted loss per share reflects the potential dilution of securities
that could share in the Companys earnings, such as common stock equivalents which may be issued upon exercise of outstanding common stock options. Diluted loss per share is identical to basic loss per share for all periods reported because
inclusion of common stock equivalents would be anti-dilutive.



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For the years ended December 31, 2005, 2004, and 2003, the following options and warrants to
purchase shares of common stock were excluded from the computation of diluted net loss per share, as the inclusion of such shares would be antidilutive:



|               |  |                          |  |           |  |        
|-------------- |  | ------------------------ |  | --------- |  | -------
|               |  | Years Ended December 31,
|               |  | 2005                     |  | 2004      |  | 2003   
|Stock options  |  | 1,462,499                |  | 1,062,499 |  | 878,592
|Stock warrants |  | 106,750                  |  |          |  |       



Effect of new
accounting standards

In March 2005, the FASB issued FIN 47, Accounting for Conditional Asset Retirement Obligations. FIN 47
clarifies that an entity must record a liability for a conditional asset retirement obligation if the fair value of the obligation can be reasonably estimated. The provision is effective no later than the end of fiscal years ending after
December 15, 2005. We do not expect FIN 47 to affect our financial condition or results of operations.



In May 2005, the FASB issued SFAS 154, Accounting Changes and Error Corrections. SFAS 154 establishes retrospective application as
the required method for reporting a change in accounting principle in the absence of explicit transition requirements specific to the newly adopted accounting principle. SFAS 154 also provides guidance for determining whether retrospective
application of a change in accounting principle is impracticable and for reporting a change when retrospective application is impracticable. SFAS 154 is effective for accounting changes and corrections of errors made in fiscal years beginning
after December 15, 2005. We do not expect the adoption of SFAS 154 to significantly affect our financial condition or results of operations.



In June 2005, the FASB ratified the consensus reached by the Task Force in EITF 05-6. The Task Force reached a consensus that leasehold improvements
that are placed in service significantly after, and not contemplated at or near the beginning of, the lease term should be amortized over the shorter of the useful life of the assets or a term that includes required lease periods and renewals that
are deemed to be reasonably assured at the date of the leasehold improvements are purchased. In addition, leasehold improvements acquired in a business combination should be amortized over the shorter of the useful lives of the assets or a term that
includes required lease periods and renewals that are deemed to be reasonably assured at the date of acquisition. EITF 05-6 is effective for leasehold improvements (within the scope of this issue) that are purchased or acquired in the reporting
period beginning after June 29, 2005. Adoption of EITF 05-6 did not affect our financial condition or results of operations.



|3. | Property and Equipment
|-- | ----------------------



As of December 31, 2004, Akesis Delaware had no property and equipment, and depreciation expense for the year ended December 31, 2004 was zero.
Property and equipment as of December 31, 2005 consist of the following:



|                             |  |      |        |                         |   |        |     |  |   |       
|---------------------------- |  | ---- | ------ | ----------------------- | - | ------ | --- |  | - | ------
|                             |  | Cost |        | AccumulatedDepreciation |   |        | Net
|Furniture and fixtures       |  | $    | 14,919 |                         | $ | (2,753 | )   |  | $ | 12,166
|Office equipment             |  |      | 6,665  |                         |   | (1,439 | )   |  |   | 5,226 
|                             |  |      |        |                         |   |        |     |  |   |       
|Total property and equipment |  | $    | 21,584 |                         | $ | (4,192 | )   |  | $ | 17,392
|                             |  |      |        |                         |   |        |     |  |   |       



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|4. | Stockholder Loans
|-- | -----------------



Akesis Delaware received working capital contributions from two related-party lenders. Included in these balances was a convertible promissory note
effective April 4, 2002 with the related-party lenders. The notes were due and payable to the related-party lenders at the earlier of 18 months from the effective date, Akesis Delaware closing a minimum financing by qualified investors in
excess of $1,000,000, execution of a licensing agreement that would provide sufficient cash flow to repay the note, or a sale of all or substantially all of the Companys assets. Interest accrues at 8% per annum based on a 360 day period.
The note, including principal and accrued interest, may be converted to stock of Akesis Delaware at any time, including Series B Preferred Stock with a conversion price of $5.00 or the same security from the closing of a minimum financing
transaction by qualified investors in excess of $1,000,000. Akesis Delaware had the right to prepay the note with a 20 day written notice to the lender in either cash or stock. If no election was made by the lender within 10 days of notice, the
prepayment would have been made in cash.



In September 2004,
the holders of the loans and the Akesis Delaware Board of Directors agreed to convert stockholder loan principal balances of $115,461 into Series C Preferred Stock at $0.40 per share for a total of 288,653 shares. The principal balances converted
into Series C Preferred Stock as of September 30, 2004. Additionally, Akesis Delaware recorded imputed interest of $14,154 as of September 30, 2004. However, interest was forgiven by the lenders, not paid upon conversion of the loans, and
accordingly was recorded as additional paid-in capital.



|5. | Commitments, Contingencies and Related Party Transactions
|-- | ---------------------------------------------------------



The Company leases in aggregate approximately 1,100 square feet of office space located in La Jolla, California, and Carefree, Arizona pursuant to two
leases each on a month-to-month basis. The Arizona lease is sublet from the Companys CEO at his cost, and the San Diego office space is sublet from Avalon Ventures. One of the Companys directors, Kevin Kinsella, is a general partner of
Avalon, and the Board of Directors has determined that the rent charged to the Company for both leases is fair and reasonable. The Company recorded rent expense during the years ended December 31, 2005, 2004, 2003, and for the cumulative period
from April 27, 1998 (date of inception) to December 31, 2005 of $24,840, $5,500, zero, and $30,340, respectively.



|6. | Stock-based Compensation
|-- | ------------------------



Stock-based compensation expense for the years ended December 31, 2005, 2004, 2003, and for the cumulative period from April 27, 1998 (date of
inception) to December 31, 2005, was $1,804,000, $1,087,500, $270, and $2,986,000, respectively. Since we have a net operating loss carryforward as of December 31, 2005, no excess tax benefits for the tax deductions related to share-based
awards were recognized in the consolidated statement of operations. At the present time, we intend to issue new common shares upon the exercise of stock options. None of the share-based awards are classified as a liability as of December 31,
2005.



Immediately following the acquisition of Akesis Delaware
by Liberty in December 2004, two executive officers became entitled, through their respective employment offer letters, to nonstatutory stock options with a term of 10 years to acquire a total of 1,062,499 shares of common stock at an exercise price
of $1.50 per share. Twenty percent of the shares of common stock subject to the options vested as of the effective date of the officers employment



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immediately following the acquisition of Akesis Delaware by Liberty and one forty-eighth (1/48th) of the remaining shares subject to the options will
vest each month following the effective date of the officers employment, subject to the officers continued employment with the Company on any such date. In addition, in the event of a change of control of the Company, then the officers
shall fully vest in and have the right to exercise the options as to all of the shares of common stock subject to the options as to which the officers would not otherwise be vested or exercisable.



The Board of Directors of Liberty also authorized and reserved 1,500,000
shares of Liberty common stock pursuant to a 2005 Stock Plan in January 2005 for option grants to Libertys employees, directors and consultants. Options were granted pursuant to such 2005 Stock Plan to an officer and an outside director during
the year ended December 31, 2005 for each of them to acquire 200,000 shares of our common stock. The stock options are Nonqualified Stock Options with a term of 10 years and an exercise price of $1.94 per share. Twenty-five percent of the
shares of common stock subject to the options vest as of the first anniversary of the officers and outside directors service to the Company, and one forty-eighth (1/48th) of the shares subject to the options vest each month
following the first anniversary of the officers and outside directors service to the Company, subject to the officers and outside directors continued service to the Company on any such date. In addition, in the event of a
change of control of the Company, then the officer and outside director shall fully vest in and have the right to exercise the options as to all of the shares of common stock subject to the options as to which the officer and outside director would
not otherwise be vested or exercisable. Both the officer and outside director joined the Company in January 2005.



The fair value of each option award is estimated on the date of grant using the Black-Scholes method for option pricing that uses the assumptions noted in
the following table. Expected volatilities are based on historical volatility of our common stock and other factors. The expected term of options granted is based on our managements estimate since our operating history is too brief to have
established historical rates for employee termination and option exercises. The risk-free interest rates are based on the U.S. Treasury yield for a period consistent with the expected term of the option in effect at the time of the grant.
Assumptions used in the Black-Scholes model for the years ended December 31, 2005 and 2004, respectively, were as follows:



|                                                        |  |                          |  |             
|------------------------------------------------------- |  | ------------------------ |  | ------------
|                                                        |  | Years Ended December 31,
|                                                        |  | 2005                     |  | 2004        
|Expected volatility                                     |  | 125%                     |  | 85%         
|Annual expected termination rate                        |  | 25%                      |  | 5%          
|Risk-fee interest rate (zero coupon U.S. Treasury Note) |  | 3.7% to 4.0%             |  | 1.9% to 3.4%
|Expected dividend yield                                 |  | 0%                       |  | 0%          



The fair value of
options granted during the years ended December 31, 2005 and 2004 was $428,584 and $4,505,500, respectively, and the fair value is amortized over the vesting period of the option using the multiple option methodology in accordance with the
provisions of SFAS No. 123(R). No options were granted during the year ended December 31, 2003.



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The following is a summary of the status of the 2004 nonstatutory options and the options under the 2005
Stock Plan for the years ended December 31, 2005 and 2004:



|                                 |  |                 |  |                                        |      |                                                   |      |                                      |   |    
|-------------------------------- |  | --------------- |  | -------------------------------------- | ---- | ------------------------------------------------- | ---- | ------------------------------------ | - | ---
|                                 |  | Numberof Shares |  | WeightedAverageExercise PricePer Share |      | WeightedAverageRemainingContractualTerm(in years) |      | AggregateIntrinsicValue(in millions)
|Balance at December 31, 2003     |  |                |  |                                        |     |                                                   |     |                                      | $ |   
|Granted                          |  | 1,062,499       |  | $                                      | 1.50 |                                                   |      |                                      |   |    
|Exercised                        |  |                |  |                                        |     |                                                   |      |                                      |   |    
|Cancelled                        |  |                |  |                                        |     |                                                   |      |                                      |   |    
|                                 |  |                 |  |                                        |      |                                                   |      |                                      |   |    
|Balance at December 31, 2004     |  | 1,062,499       |  | $                                      | 1.50 |                                                   | 9.92 |                                      | $ | 4.5
|Granted                          |  | 400,000         |  | $                                      | 1.94 |                                                   |      |                                      |   |    
|Exercised                        |  |                |  |                                        |     |                                                   |      |                                      |   |    
|Cancelled                        |  |                |  |                                        |     |                                                   |      |                                      |   |    
|                                 |  |                 |  |                                        |      |                                                   |      |                                      |   |    
|Balance at December 31, 2005     |  | 1,462,499       |  | $                                      | 1.62 |                                                   | 9.21 |                                      | $ | 4.9
|                                 |  |                 |  |                                        |      |                                                   |      |                                      |   |    
|Exercisable at December 31, 2005 |  | 425,000         |  | $                                      | 1.50 |                                                   | 9.21 |                                      | $ | 1.8
|                                 |  |                 |  |                                        |      |                                                   |      |                                      |   |    



The grant-date fair
values of options granted during the years ended December 31, 2005 and 2004 were $1.07 per share and $4.24 per share, respectively.



A summary of the status of our non-vested stock options as of December 31, 2005 and 2004 and changes during the years then ended are presented below.



|                               |  |                 |   |  |                                      |     
|------------------------------ |  | --------------- | - |  | ------------------------------------ | ----
|                               |  | Numberof shares |   |  | AverageGrant-DateFair ValuePer Share
|Nonvested at December 31, 2003 |  |                |   |  |                                      |    
|Granted                        |  | 1,062,499       |   |  | $                                    | 4.24
|Vested                         |  | (212,500        | ) |  | $                                    | 4.24
|                               |  |                 |   |  |                                      |     
|Nonvested at December 31, 2004 |  | 849,999         |   |  | $                                    | 4.24
|Granted                        |  | 400,000         |   |  | $                                    | 1.07
|Vested                         |  | (212,500        | ) |  | $                                    | 4.24
|                               |  |                 |   |  |                                      |     
|Nonvested at December 31, 2005 |  | 1,037,499       |   |  | $                                    | 3.02
|                               |  |                 |   |  |                                      |     



As of
December 31, 2005, there was $2.1 million of total unrecognized compensation cost, related to non-vested stock options, which is expected to be recognized over a weighted-average period of approximately three years. The total fair
values of shares vested during the years ended December 31, 2005 and 2004 were $901,000 and $901,000 respectively.



1998 Stock Option Plan

Akesis
Delaware adopted the 1998 Incentive Stock Plan and terminated such immediately prior to the acquisition by Liberty of Akesis Delaware. All then outstanding options and rights were terminated immediately prior to the acquisition by Liberty of Akesis
Delaware. Under the plan, nonstatutory stock options and stock purchase rights were granted to service providers, and incentive stock options were granted to employees. The fair market value of the shares was determined on the date of the option
grant.



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The term of each option was 10 years unless sooner terminated or amended by the Board. In the case of an
incentive stock option granted to an optionee who, at the time of the grant, owned more than 10% of the voting power of all classes of stock, the term of the option was five years from the date of grant or as provided on the option agreement.



The exercise price of an option was determined by the
Companys administrator with the following exceptions: For an incentive stock option granted to an employee who owned more than 10% percent of the voting power of all classes of stock, the exercise price was no less than 110% of the fair market
value per share on the date of grant. The exercise price for employees was no less than 100% of the fair market value on the date of grant. For nonstatutory stock options, the service provider who owned more than 10% percent of the voting power of
all classes of stock, the exercise price was no less than 110% of the fair market value per share on the date of grant. The exercise price for other service providers was no less than 85% of the fair market value on the date of grant.



Options vested at a rate of no less than 20% per year over five years
from the date of grant, except for options granted to officers, directors, and consultants.



The following are summaries of the status of options under the 1998 Incentive Stock Plan as of certain dates:



|                             |  |                    |   |  |                                |     
|---------------------------- |  | ------------------ | - |  | ------------------------------ | ----
|                             |  | OptionsOutstanding |   |  | Weighted-AverageExercise Price
|Balance at December 31, 2002 |  | 878,592            |   |  | $                              | 0.15
|Granted                      |  |                   |   |  |                                |    
|Exercised                    |  |                   |   |  |                                |    
|Cancelled                    |  |                   |   |  |                                |    
|                             |  |                    |   |  |                                |     
|Balance at December 31, 2003 |  | 878,592            |   |  | $                              | 0.15
|Granted                      |  | 115,233            |   |  | $                              | 0.12
|Exercised                    |  | (927,714           | ) |  | $                              | 0.14
|Cancelled                    |  | (66,111            | ) |  | $                              | 0.11
|                             |  |                    |   |  |                                |     
|Balance at December 31, 2004 |  |                   |   |  | $                              |    
|                             |  |                    |   |  |                                |     



|7. | Common Stock
|-- | ------------



On December 30, 2005, the Company entered into a Common Stock and Warrant Purchase Agreement with certain accredited investors and consummated the
initial closing thereunder where it sold 175,000 shares of its common stock at a purchase price of $2.00 per share. In addition, the Company issued warrants to the investors to purchase up to 87,500 shares of its common stock in connection with the
financing. The warrants are exercisable for shares of the Companys common stock for three years from the date of the initial closing at an exercise price per share of $3.00. The net proceeds from the financing after cash expenses related to
the financing were $340,075. All the shares and warrants issued in connection with the financing were exempt from registration by virtue of Section 4(2) of the Securities Act of 1933, as amended. Subsequent closings of this financing were held
in 2006 (see Note 9).



In connection with the Common Stock and
Warrant Purchase Agreement described in the preceding paragraph, the Company paid its placement agents (a) a cash fee equal to one percent (1%) of all funds invested by investors introduced by such finders (excluding amounts paid by



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##### Table of Contents

investors upon exercise of warrants), and (b) warrants to purchase up to 19,250 shares of its common stock. The warrants are exercisable for five years
from the date of issuance at an exercise price per share of $2.00. The one percent cash commission totaling $3,500 paid to the placement agents was recorded as a reduction of paid in capital. The fair value of the warrants issued to the placement
agents in connection with the financing was determined to be $31,607 using a Black-Scholes model, and that amount was recorded as consulting fees. Warrant issuances to the placement agents were exempt from registration by virtue of Section 4(2)
of the Securities Act of 1933, as amended.



|8. | Income Taxes
|-- | ------------



At December 31, 2005, Akesis Delaware had no federal income tax expense or benefit but did have federal tax net operating loss carryforwards of
approximately $3.5 million. The federal net operating loss carryforwards will begin to expire in 2018, unless previously utilized. Pursuant to Internal Revenue Code Section 382 and 383, use of Akesis Delawares net operating loss
carryforwards may be limited if a cumulative change in ownership of more than 50% occurs within a three-year period. No assessment has been made as to whether such a change in ownership has occurred. The Company incurred $3,200 and $1,600 of
statutory minimum state expense for the years ended 2005 and 2004, respectively. Prior to 2004 the Company was not subject to statutory minimum state tax expense.



Significant components of Akesis Delawares net deferred tax assets at December 31, 2005 and 2004 are shown below.
A valuation allowance of $1,279,000 and $835,000 has been established to offset the net deferred tax assets at December 31, 2005 and 2004, respectively, as realization of such assets is uncertain.



|                                            |  |              |            |   |      |   |          |  
|------------------------------------------- |  | ------------ | ---------- | - | ---- | - | -------- | -
|                                            |  | December 31, |           
|                                            |  | 2005         |            |   | 2004 |  
|Noncurrent Net Operating Loss Carryforwards |  | $            | 1,241,000  |   |      | $ | 787,000  |  
|Other noncurrent                            |  |              | 25,000     |   |      |   | 35,000   |  
|                                            |  |              |            |   |      |   |          |  
|Total noncurrent                            |  |              | 1,266,000  |   |      |   | 822,000  |  
|Other current                               |  |              | 13,000     |   |      |   | 13,000   |  
|                                            |  |              |            |   |      |   |          |  
|Total deferred tax assets                   |  |              | 1,279,000  |   |      |   | 835,000  |  
|Deferred tax asset valuation allowance      |  |              | (1,279,000 | ) |      |   | (835,000 | )
|                                            |  |              |            |   |      |   |          |  
|Net deferred taxes                          |  | $            |           |   |      | $ |         |  
|                                            |  |              |            |   |      |   |          |  



|9. | Subsequent Events (Unaudited)
|-- | -----------------------------



Funding Entered Into Subsequent to December 31, 2005

During the first quarter of 2006, the Company had two additional closings under the December 30, 2005 Common Stock and Warrant Purchase Agreement described in Note 7 with certain accredited investors where
it sold an additional 105,000 shares of its common stock at a purchase price of $2.00 per share. In addition, the Company issued warrants to the investors to purchase up to 52,500 shares of its common stock in connection with the financing. The
warrants are exercisable for shares of the Companys common stock for three years from the date of the initial closing at an exercise price per share of $3.00. The net proceeds from the financing after cash expenses related to the financing
were approximately $201,000. All the shares and warrants issued in connection with the financing were exempt from registration by virtue of Section 4(2) of the Securities Act of 1933, as amended.



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In connection with the Common Stock and Warrant Purchase Agreement described in the preceding paragraph,
the Company paid its placement agents (a) a cash fee equal to one percent (1%) of all funds invested by investors introduced by such finders (excluding amounts paid by investors upon exercise of warrants), and (b) warrants to purchase
up to 11,550 shares of its common stock. The warrants are exercisable for five years from the date of issuance at an exercise price per share of $2.00. The one percent cash commission totalling $2,100 paid to the placement agents was recorded as a
reduction of paid in capital. The fair value of the warrants issued to the placement agents in connection with the financing was determined to be $18,965 using a Black-Scholes model, and that amount was recorded as consulting fees. Warrant issuances
to the placement agents were exempt from registration by virtue of Section 4(2) of the Securities Act of 1933, as amended.



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##### Table of Contents

|Item 9. | Changes in and Disagreements With Accountants on Accounting and Financial Disclosure
|------- | ------------------------------------------------------------------------------------



None.



Item 9A.Controls and Procedures



Evaluation of disclosure controls and procedures. Our Chief Executive Officer and our Chief Financial Officer evaluated the effectiveness of our disclosure controls and procedures as of the end of the period
covered by this Annual Report on Form 10-K. Based on this evaluation, our Chief Executive Officer and our Chief Financial Officer have concluded that the Companys disclosure controls and procedures are effective to ensure that information
we are required to disclose in reports that we file or submit under the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified in Securities and Exchange Commission rules and forms.



Changes in internal control over financial reporting. There
was no change in our internal control over financial reporting that occurred during the period covered by this Annual Report on Form 10-K that has materially affected, or is reasonably likely to materially affect, our internal control over
financial reporting.



Item 9B.Other Information



None.



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##### Table of Contents

PART III



Item 10.Directors and Officers of the Registrant



The information regarding our directors and executive officers is incorporated by reference from Directors and Executive Officers in our Proxy
Statement for our 2006 Annual Meeting of Stockholders.



Section 16(a) Beneficial Ownership Reporting Compliance



Section 16(a) of the Securities Exchange Act of 1934, as amended (the Exchange Act) requires the Companys executive officers and directors and persons who own more than ten percent (10%) of
a registered class of our equity securities to file reports of ownership and changes in ownership with the Securities and Exchange Commission, or SEC, and the National Association of Securities Dealers, Inc. Executive officers, directors and greater
than ten percent (10%) stockholders are required by Commission regulation to furnish us with copies of all Section 16(a) forms they file. Based solely on our review of such forms received and the written representations of our executive
officers, directors and greater than ten percent (10%) stockholders, we have determined that due to an administrative oversight Stuart A. Fine was delinquent with respect to one reporting obligation as set forth in Section 16(a) of the
Exchange Act.



Item 11.Executive Compensation



The information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above under the heading Executive Compensation and Other Matters.



Item 12.Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters



The information required by this Item regarding security ownership of certain beneficial owners and management is incorporated by reference from our
definitive Proxy Statement referred to in Item 10 above where it appears under the heading Security Ownership of Certain Beneficial Owners and Management. The information required by this Item regarding equity compensation plans is
incorporated by reference from Item 5 of this Annual Report on Form 10-K.



Item 13.Certain Relationships and Related Transactions



The information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above where it appears
under the heading Certain Relationships and Related Transactions.



Item 14.Principal Accountant Fees and Services



The information required by this Item is incorporated by reference from our definitive Proxy Statement referred to in Item 10 above where it appears
under the heading Principal Accountant Fees and Services.



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##### Table of Contents

PART IV



Item 15.Exhibits and Financial Statement Schedules



| | (a) | The following documents are filed as part of this Form 10-K:
| | --- | ------------------------------------------------------------



| | (1) | Consolidated Financial Statements (included in Part II of this report):
| | --- | -----------------------------------------------------------------------



| |  |  | Report of Swenson Advisors, LLP, Independent Registered Public Accounting Firm.
| | - |  | -------------------------------------------------------------------------------



| |  |  | Consolidated Balance Sheets
| | - |  | ---------------------------



| |  |  | Consolidated Statements of Operations
| | - |  | -------------------------------------



| |  |  | Consolidated Statement of Stockholders Equity
| | - |  | ----------------------------------------------



| |  |  | Consolidated Statements of Cash Flows
| | - |  | -------------------------------------



| |  |  | Notes to Consolidated Financial Statements
| | - |  | ------------------------------------------



| | (2) | Consolidated Financial Statement Schedules:
| | --- | -------------------------------------------



All consolidated financial statement schedules are omitted because the information is inapplicable or presented in the notes to the financial statements.



| | (3) | Exhibits:
| | --- | ---------



|               |     |  |                                                                                                                                                                
|-------------- | --- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit Number |     |  | Description                                                                                                                                                    
|2.1            | (1) |  | Agreement and Plan of Merger and Reorganization dated September 27, 2004 by and among the Registrant, Ann Arbor Acquisition Corporation, and Liberty Mint, Ltd.
|3.1            | (2) |  | Articles of Incorporation, as amended, of the Registrant                                                                                                       
|3.2            | (2) |  | Bylaws of the Registrant                                                                                                                                       
|4.1            | (3) |  | Form of Warrant to Purchase Common Stock                                                                                                                       
|4.2            | (3) |  | Form of Warrant to Purchase Common Stock                                                                                                                       
|10.1           | (2) |  | Employment Offer Letter dated December 13, 2004 for Edward B. Wilson, President and CEO of the Registrant                                                      
|10.2           | (2) |  | Employment Offer Letter dated December 13, 2004 for John T. Hendrick, CFO of the Registrant                                                                    
|10.3           | (2) |  | Stand-Alone Stock Option Agreement dated January 24, 2005 for Edward B. Wilson, President and CEO of the Registrant                                            
|10.4           | (2) |  | Stand-Alone Stock Option Agreement dated January 24, 2005 dated for John T. Hendrick, CFO of the Registrant                                                    
|10.5           | (2) |  | 2005 Stock Plan of the Registrant                                                                                                                              
|10.6           | (3) |  | Common Stock and Warrant Purchase Agreement dated December 30, 2005                                                                                            
|10.7           | (3) |  | Form of Finder Agreement                                                                                                                                       
|14.1           | (4) |  | Code of Ethics of the Registrant                                                                                                                               
|23.1           |     |  | Consent of Swenson Advisors, LLP, Independent Registered Public Accounting Firm.                                                                               
|31.1           |     |  | Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                             
|31.2           |     |  | Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                             
|32.1           |     |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                 

---

|(1) | Incorporated by reference to the Registrants Form 8-K as filed with the SEC on
September 28, 2004.
|--- | ---------------------------------------------------------------------------------------------------

|(2) | Incorporated by reference to the Registrants Form 10-K as filed with the SEC
on March 25, 2005.
|--- | ------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference to the Registrants Form 8-K as filed with the SEC
on January 6, 2006.
|--- | ------------------------------------------------------------------------------------------------

|(4) | Incorporated by reference to the Registrants Amendment to Form 10-K as filed with
the SEC on April 28, 2005.
|--- | -------------------------------------------------------------------------------------------------------------



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##### Table of Contents

SIGNATURES



Pursuant to the
requirements of Section 13 or 15(d) of the Securities and Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



AKESIS PHARMACEUTICALS, INC.By:

/s/ Edward B. WilsonEdward B. Wilson,President, Chief Executive Officer and Director




Dated: March 28, 2006



POWER OF ATTORNEY



KNOW ALL PERSONS BY THESE PRESENTS, that each person whose
signature appears below hereby constitutes and appoints Ed Wilson and John Hendrick and each of them acting individually, as his attorneys-in-fact, each with full power of substitution, for him in any and all capacities, to sign any and all
amendments to this Form 10-K, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said
attorney to any and all amendments said Form 10-K.



Pursuant to the requirements of the Securities Act, this Form 10-K has been signed by the following persons in the capacities and on the dates indicated:



|                                       |  |                                                                               |  |               
|-------------------------------------- |  | ----------------------------------------------------------------------------- |  | --------------
|Signature                              |  | Title                                                                         |  | Date          
|                                       |  |                                                                              
|/s/ Edward B. WilsonEdward B. Wilson   |  | President, Chief Executive Officer and Director (Principal Executive Officer) |  | March 28, 2006
|                                       |  |                                                                              
|/s/ John T. HendrickJohn T. Hendrick   |  | Chief Financial Officer (Principal Financial and Accounting Officer)          |  | March 28, 2006
|                                       |  |                                                                              
|/s/ Kevin J. KinsellaKevin J. Kinsella |  | Director                                                                      |  | March 28, 2006
|                                       |  |                                                                              
|/s/ Kevin SayerKevin Sayer             |  | Director                                                                      |  | March 28, 2006
|                                       |  |                                                                              
|/s/ John F. Steel, IVJohn F. Steel, IV |  | Director                                                                      |  | March 28, 2006



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##### Table of Contents

EXHIBIT INDEX



|               |     |  |                                                                                                                                                                
|-------------- | --- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit Number |     |  | Description                                                                                                                                                    
|2.1            | (1) |  | Agreement and Plan of Merger and Reorganization dated September 27, 2004 by and among the Registrant, Ann Arbor Acquisition Corporation, and Liberty Mint, Ltd.
|3.1            | (2) |  | Articles of Incorporation, as amended, of the Registrant                                                                                                       
|3.2            | (2) |  | Bylaws of the Registrant                                                                                                                                       
|4.1            | (3) |  | Form of Warrant to Purchase Common Stock                                                                                                                       
|4.2            | (3) |  | Form of Warrant to Purchase Common Stock                                                                                                                       
|10.1           | (2) |  | Employment Offer Letter dated December 13, 2004 for Edward B. Wilson, President and CEO of the Registrant                                                      
|10.2           | (2) |  | Employment Offer Letter dated December 13, 2004 for John T. Hendrick, CFO of the Registrant                                                                    
|10.3           | (2) |  | Stand-Alone Stock Option Agreement dated January 24, 2005 for Edward B. Wilson, President and CEO of the Registrant                                            
|10.4           | (2) |  | Stand-Alone Stock Option Agreement dated January 24, 2005 dated for John T. Hendrick, CFO of the Registrant                                                    
|10.5           | (2) |  | 2005 Stock Plan of the Registrant                                                                                                                              
|10.6           | (3) |  | Common Stock and Warrant Purchase Agreement dated December 30, 2005                                                                                            
|10.7           | (3) |  | Form of Finder Agreement                                                                                                                                       
|14.1           | (4) |  | Code of Ethics of the Registrant                                                                                                                               
|23.1           |     |  | Consent of Swenson Advisors, LLP, Independent Registered Public Accounting Firm.                                                                               
|31.1           |     |  | Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                             
|31.2           |     |  | Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                             
|32.1           |     |  | Certification of Chief Executive Officer and Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                 

---

|(1) | Incorporated by reference to the Registrants Form 8-K as filed with the SEC on
September 28, 2004.
|--- | ---------------------------------------------------------------------------------------------------

|(2) | Incorporated by reference to the Registrants Form 10-K as filed with the SEC
on March 25, 2005.
|--- | ------------------------------------------------------------------------------------------------

|(3) | Incorporated by reference to the Registrants Form 8-K as filed with the SEC
on January 6, 2006.
|--- | ------------------------------------------------------------------------------------------------

|(4) | Incorporated by reference to the Registrants Amendment to Form 10-K as filed with
the SEC on April 28, 2005.
|--- | -------------------------------------------------------------------------------------------------------------



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