**Exhibit
      31**





**Certification
      Pursuant to pursuant to Rule 13a-14(a) or Rule 15d-14(a)**


**of
      the Securities Exchange Act of 1934, as amended**





I,
      Diane
      S Button, certify that:





1.
      I have
      reviewed this quarterly report on Form 10-QSB of Cactus Ventures, Inc. (the
      "Company");





2.
      Based
      on my knowledge, this report does not contain any untrue statement of a material
      fact or omit to state a material fact necessary to make the statements made,
      in
      light of the circumstances under which such statements were made, not misleading
      with respect to the period covered by this report;





3.
      Based
      on my knowledge, the financial statements, and other financial information
      included in this report, fairly present in all material respects the financial
      condition, results of operations and cash flows of the registrant as of, and
      for, the periods presented in this report;





4.
      As the
      registrant's certifying officer, I am responsible for establishing and
      maintaining disclosure controls and procedures (as defined in Exchange Act
      Rules
      13a-15(e) and 15d-15(e)) for the registrant and I have:





a)
            designed
                such disclosure controls and procedures, or caused such disclosure
                controls and procedures to be designed under our supervision, to
                ensure
                that material information relating to the registrant, including its
                consolidated subsidiaries, is made known to us by others within those
                entities, particularly during the period in which this report is
                being
                prepared;





b)
            designed
                such internal control over financial reporting, or caused such internal
                control over financial reporting to be designed under my supervision,
                to
                provide reasonable assurance regarding the reliability of financial
                reporting and the preparation of financial statements for external
                purposes in accordance with generally accepted accounting
                principles;





c)
            evaluated
                the effectiveness of the registrant's disclosure controls and procedures
                and presented in this report our conclusions about the effectiveness
                of
                the disclosure controls and procedures, as of the end of the period
                covered by this report based on such evaluation;
                and





d)
            disclosed
                in this report any change in the registrant's internal control over
                financial reporting that occurred during the period covered by this
                report
                that has materially affected, or is reasonably likely to materially
                affect, the registrant's internal control over financial
                reporting.





5.
      As the
      registrant's certifying officer, I have disclosed, based on my most recent
      evaluation of internal control over financial reporting, to the registrant's
      auditors and the audit committee of registrant's board of directors (or persons
      performing the equivalent function):





a)  all
      significant deficiencies and material weaknesses in the design or operation
      of
      internal control over financial reporting which are reasonably likely to
      adversely affect the registrant's ability to record, process, summarize and
      report financial information; and





b)  any
      fraud, whether or not material, that involves management or other employees
      who
      have a significant role in the registrant's internal control over financial
      reporting.






Date:
      May 10, 2007          /s/ 
Diane
      S.
      Button


Chief
      Executive Officer and


Chief
      Financial Officer