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Title:   Author  item
                                            MAGO, ROHIT - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            ZHANG, PENG - Plant Breeding Instituteitem
                                            VAUTRIN, SONIA - Institut National De La Recherche Agronomique (INRA)item
                                            SIMKOVA, HANA - Institute Of Experimental Botanyitem
                                            BANSAL, URMIL - Plant Breeding Instituteitem
                                            LUO, MING-CHENG - University Of Californiaitem
                                            Rouse, Matthew

                                                         - *Matt*item
                                            KARAOGLU, HAYDAR - Plant Breeding Instituteitem
                                            PERIYANNAN, SAMBASIVAM - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            Kolmer, Jamesitem
                                            Jin, Yueitem
                                            AYLIFFE, MICHAEL - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            BARIANA, HARBANS - Plant Breeding Instituteitem
                                            PARK, ROBERT - Plant Breeding Instituteitem
                                            MCINTOSH, ROBERT - Plant Breeding Instituteitem
                                            DOLEZEL, JAROSLAV - Institute Of Experimental Botanyitem
                                            BERGES, HELENE - Institut National De La Recherche Agronomique (INRA)item
                                            SPIELMEYER, WOLFGANG - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            LAGUDAH, EVANS - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            ELLIS, JEFF - Commonwealth Scientific And Industrial Research Organisation (CSIRO)item
                                            DODDS, PETER - Commonwealth Scientific And Industrial Research Organisation (CSIRO)
  Submitted to: Nature Plants
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 10/27/2015
                                    Publication  Date: 11/30/2015
                                    Citation: Mago, R., Zhang, P., Vautrin, S., Simkova, H., Bansal, U., Luo, M., Rouse, M.N., Karaoglu, H., Periyannan, S., Kolmer, J.A., Jin, Y., Ayliffe, M., Bariana, H., Park, R., Mcintosh, R., Dolezel, J., Berges, H., Spielmeyer, W., Lagudah, E., Ellis, J., Dodds, P. 2015. The wheat Sr50 gene reveals rich diversity at a cereal disease resistance locus. Nature Plants. 15186:1-16. doi:10.1038/nplants.2015.186.Interpretive Summary: Wheat stem rust caused by the fungal pathogen Puccinia graminis f. sp. tritici is a major threat to wheat production worldwide. The appearance and subsequent spread of Ug99 and other virulent races have elucidated the continuing need for new resistance sources to protect against this devastating pathogen. We identify the wheat stem rust resistance gene Sr50 by physical mapping, mutation and complementation as homologous to barley Mla encoding a Coiled-Coil-Nucleotide-Binding-Leucine-Rich Repeat (CC-NB-LRR) protein. We show that Sr50 confers a unique resistance specificity, different from Sr31 and other genes on rye chromosome 1RS, and is effective against the broadly virulent Ug99 race lineage. Extensive haplotype diversity at the rye Sr50 locus holds promise for mining effective resistance genes. Sr50 is effective against a broad range of worldwide stem rust pathogen races and is the first stem rust resistance gene cloned from the tertiary gene pool of wheat. This advance will allow introgression of Sr50 into new wheat varieties separately from deleterious rye sequences and pyramiding of this gene with other broadly effective Sr genes either through conventional breeding or by transgenic delivery to provide durable stem rust control.
                                Technical Abstract: We identify the wheat stem rust resistance gene Sr50 by physical mapping, mutation and complementation as homologous to barley Mla encoding a Coiled-Coil-Nucleotide-Binding-Leucine-Rich Repeat (CC-NB-LRR) protein. We show that Sr50 confers a unique resistance specificity, different from Sr31 and other genes on rye chromosome 1RS, and is effective against the broadly virulent Ug99 race lineage. Extensive haplotype diversity at the rye Sr50 locus holds promise for mining effective resistance genes.


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