U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Genomics and Improvement Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                                    Software
                People

                    Staff Listing
                                    Careers


        


                    AIP
                        Home
                                    About
                                    Publications
                                    Software
                                    People
                                    Collaborations
                                    Careers
                                    Centennial
                                    Contact
                                    Dairy industry links
                    DirectionsSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Genomics and Improvement Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- IACUC
- Home
- About
- Publications
- Software
- People
- Collaborations
- Careers
- Centennial
- Contact
- Dairy industry links
- Home
- Queries login
- News
- Animal Evaluation lists
- Genotype counts

Title:   Author  item
                                            ORTEGA, M. SOFIA - University Of Floridaitem
                                            DENICOL, ANNA - University Of Floridaitem
                                            Cole, Johnitem
                                            Null, Danielitem
                                            HANSEN, PETER - University Of Florida
  Submitted to: Animal Genetics
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 12/24/2015
                                    Publication  Date: 6/1/2016
                                    Citation: Ortega, M., Denicol, A.C., Cole, J.B., Null, D.J., Hansen, P.J. 2016. Use of single nucleotide polymorphisms in candidate genes associated with daughter pregnancy rate for prediction of genetic merit for reproduction in Holstein cows. Animal Genetics. 47(3):288–297.Interpretive Summary: The effects of 69 DNA markers associated with fertility and production in previous studies were confirmed in a separate population of Holstein cows. Thirty of the 69 markers tested had statistically significant associations with three measures of fertility in cows. When those 39 markers were added to the set used to compute the national genetic evaluations, the reliability of the evaluations increased by 0.2%, which is similar to the gain from using a genotyping chip with 777,000 markers. These results can be used to increase the accuracy of fertility productions in 9,000,000 dairy cows in the US.
                                Technical Abstract: We evaluated 69 SNPs in genes previously related to fertility and production traits for relationship to daughter pregnancy rate (DPR), cow conception rate (CCR) and heifer conception rate (HCR) in a separate population of Holstein cows grouped according to their predicted transmitting ability for DPR: <= -1 (n=1287) and >= 1.5 (n=1036). Genotyping was by Sequenom MassARRAY®. There were a total of 39 SNPs associated with the three fertility traits. The SNPs that explained the greater proportion of the genetic variation for DPR were COQ9 (3.2%), EPAS1 (1.0%), CAST (1.0%), C7H19orf60 (1.0%), and MRPL48 (1.0%); for CCR were GOLGA4 (2.4%), COQ9 (1.8%), EPAS1 (1.1%) and MRPL48 (0.8%), and for HCR were HSD17B7 (1.0%), APB3B1 (0.8%), HSD17B12 (0.7%) and CACNA1D (0.6%).  Inclusion of 39 SNPs previously associated to DPR in the genetic evaluation system increased the reliability of predicted transmitting ability (PTA) for DPR by 0.2%. Many of the genes represented by SNPs associated with fertility are involved in steroidogenesis or are regulated by steroids.  A large proportion of SNPs previously associated with genetic merit for fertility in Holstein bulls maintained their association in a separate population of cows. The inclusion of these genes in genetic evaluation can improve reliabilities of genomic estimates for fertility.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov