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 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





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Title:   Author  item
                                            WU, RYAN - University Of Marylanditem
                                            CAO, LEI - Mississippi State Universityitem
                                            MATTSON, ELLIOT - University Of Marylanditem
                                            WITWER, KENNETH - Johns Hopkins Universityitem
                                            Cao, Jayitem
                                            Zeng, Huaweiitem
                                            HE, XIN - University Of Marylanditem
                                            COMBS, GERALD - Former ARS Employeeitem
                                            CHENG, WEN-HSING - University Of Maryland
  Submitted to: Aging Cell
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 8/18/2016
                                    Publication  Date: 2/1/2017
                                    Publication URL: https://handle.nal.usda.gov/10113/5832844Citation: Wu, R.T., Cao, L., Mattson, E., Witwer, K.W., Cao, J.J., Zeng, H., He, X., Combs, G.F., Cheng, W. 2017. Opposing impacts on healthspan and longevity by limiting dietary selenium in Telomere Dysfunctional mice. Aging Cell. 16(1):125-135.Interpretive Summary: Selenium (Se) is an essential trace element essential for optimal health. We investigated the role of Se in longevity and healthspan in a mouse model of healthy aging in humans with short telomeres. Telomere shortening is associated with aging, mortality and aging-related diseases. We found that while Se deficiency promotes longevity, it worsens age-related degenerations and exacerbates age-dependent metabolic disorders, such as osteoporosis, grey hair, alopecia, cataract, and delayed wound healing. The results from this animal study show that Se at nutritional levels has opposing roles in longevity and healthspan. Therefore, the effects of Se on nutritional genomics, metabolism and aging should be considered in recommending Se intake in the future.
                                Technical Abstract: Selenium (Se) is an essential trace element essential for optimal health. We investigated the role of Se in longevity and healthspan in a mouse model of healthy aging in humans with short telomeres. Telomere shortening is associated with aging, mortality and aging-related diseases. We found that while Se deficiency promotes longevity, it worsens age-related degenerations and exacerbates age-dependent metabolic disorders, such as osteoporosis, grey hair, alopecia, cataract, and delayed wound healing. The results from this animal study show that Se at nutritional levels has opposing roles in longevity and healthspan. Therefore, the effects of Se on nutritional genomics, metabolism and aging should be considered in recommending Se intake in the future.


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