U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Obesity and Metabolism Research: Davis, CA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Laboratories
                        Bennett Group
                                    Huang Group
                                    Keim Group
                                    Laugero Group
                                    Newman GroupSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            RESVANI, R - Laval Universityitem
                                            CIANFLONE, K - Laval Universityitem
                                            MCGAHAN, J - University Of Californiaitem
                                            BERGLUND, L - University Of Californiaitem
                                            BERMER, A - University Of Californiaitem
                                            Keim, Nancyitem
                                            GRIFFEN, S - University Of Californiaitem
                                            HAVEL, P - University Of Californiaitem
                                            STANHOPE, K - University Of California
  Submitted to: Obesity
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 12/30/2014
                                    Publication  Date: 3/20/2013
                                    Citation: Resvani, R., Cianflone, K., Mcgahan, J.P., Berglund, L., Bermer, A.A., Keim, N.L., Griffen, S.C., Havel, P.J., Stanhope, K.L. 2013. Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin, and adiponectin: Relationships with metabolic outcomes. Obesity. 10.1002.Interpretive Summary: Acylation Stimulating Protein (ASP) is produced by the body’s fat cells, circulates in the blood, and is known to increase the formation of triglycerides in fat cells by stimulating the uptake of the fatty acid building blocks. Little is known about the effect of different dietary components on ASP in humans. In this study we compared circulating levels of ASP in response to consumption of beverages sweetened with glucose or fructose. We found that the ingestion of fructose, and to a lesser extent glucose, led to increases in plasma ASP, but only when the total calorie intake exceeded that required for maintaining body weight. This increase in ASP was related to increases in circulating triglyceride concentrations, measured in the evening after eating a standardized meal. Together these observations suggest that under conditions when circulating triglycerides increase, ASP production increases, thereby assisting with the removal of the triglycerides from the blood into the fat cells. Further investigation of these dietary effects on ASP is needed to better understand these relationships.
                                Technical Abstract: OBJECTIVE: The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined.

DESIGN AND METHODS: Thirty two overweight/obese adults consumed glucose- or fructose-sweetened beverages (25% energy requirement) with their ad libitum diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy-balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks.

RESULTS: Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late-evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra-abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24-h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24-h insulin levels.

CONCLUSIONS: The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov