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Title:   Author  item
                                            LINSAY  DAVID S  - AUBURN UNIVitem
                                            LENZ  S D  - AUBURN UNIVitem
                                            COLE  R A  - AUBURN UNIVitem
                                            Dubey, Jitenderitem
                                            BLAGBURN  B L  - AUBURN UNIV
  Submitted to: Journal of Parasitology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/6/1995
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Neospora caninum is a recently discovered protozoan parasite.  It causes abortion in livestock and deaths in companion animals.  Its life cycle and sources of infection are unknown.  Life cycle studies are hampered because there is no suitable animal model.  Scientists at the Beltsville Agricultural Research Center and Auburn University have developed a  laboratory mouse model using inbred BALB/C mice.  This model should help research on chemotherapy and immunology of neosporosis.
                                Technical Abstract: Neospora caninum is a protozoan parasite that causes severe disease in transplacentally infected dogs and abortions in domestic ruminants. Rodent models of neosporosis rely on treatment of hosts with methylprednisolone acetate (MPA) to enhance infections.  The present study reports the development of an inbred BALB/C mouse model that results in  central nervous system neosporosis in the absence of MPA treatment.  Seven of 12 BALB/c mice died 26 to 70 days after subcutaneous (s.c.) inoculation with tachyzoites of the NC-1 strain of N. caninum and none of 12 BALB/c mice died after s.c. inoculation with tachyzoites of the NC-3 strain. None of 8 HSD:ICR mice (4 mice, NC-1 strain; 4 mice, NC-3 strain) developed clinical neosporosis or died after s.c.  inoculation with tachyzoites.  Control BALB/c (2 mice) and HSD:ICR (2 mice) mice s.c. inoculated with Hanks' balanced salt solution did not develop clinical  signs of disease.  Some mice in all N.  caninum inoculated groups had brain lesions, but significantly (less than or equal to 0.05) more BALB/c mice inoculated with the NC-1 strain had brain lesions.


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