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Title:   Author  item
                                            Dubey, Jitenderitem
                                            METZGER JR  FRED  - METZGER ANML HOSP, PAitem
                                            HATTEL  ARTHUR L  - PA STATE UNIVitem
                                            LINDSAY  DAVID S  - AUBURN UNIVitem
                                            FRITZ  DAVID L  - ARMY MED RES INST INF DIS
  Submitted to: Veterinary Dermatology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/6/1995
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Neospora caninum is a recently recognized parasite of livestock and companion animals.  It causes abortion in livestock and paralysis in dogs. Its sources of infection and life cycle are unknown.  There is no effective therapy for neosporosis in animals.  Scientists at the Beltsville Agricultural Research Center and the Pennsylvania State  University report successful treatment of ulcers in the skin of a dog due to neosporosis medicated in the clindamycin.  The results will be of use to veterinarians in practice and in academia.
                                Technical Abstract: Pyogranulomatous dermatitis caused by the protozoan parasite Neospora caninum was diagnosed in a 12-year-old Golden Retriever dog.  Multiple draining nodules were located in the skin of the head and thorax. Numerous tachyzoites of N. caninum were found in histologic section of the biopsy tissue from the cutaneous nodules and the diagnosis was confirmed  by immunohistochemical staining and by electron microscopic examination. The dog had a 1:3,200 serum antibody titer to N.  caninum in the indirect fluorescent antibody test.   The cutaneous lesions resolved after a 45 day treatment with clindamycin hydrochloride.  The dog eventually died because of lymphosarcoma and also had a latent infection with Toxoplasma gondii. Neospora caninum could not be demonstrated by bioassays in cell culture or mice inoculated with canine tissue obtained at necropsy.  Only degenerating N. caninum tachyzoites were seen in skin tissue taken at  necropsy.  These observations indicate that neosporosis should be considered in the differential diagnosis of pyogranulomatous dermatitis in dogs and that clindamycin may be an effective drug for treating cutaneous neosporosis.


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