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Title:   Author  item
                                            SIEGEL  H S  - PENN STATE UNIVERSITYitem
                                            MASHALY  M M  - PENN STATE UNIVERSITYitem
                                            BRILES  W E  - NORTHERN ILLINOIS UNIVitem
                                            Lillehoj, Hyunitem
                                            SIEGEL  P B  - VIRGINIA POLYTECHNIC UNIVitem
                                            DUNNINGTON  E A  - VIRGINIA POLYTECHNIC UNIV
  Submitted to: Congress International Society Develop Comparative Immunology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/1/1994
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: In two experiments, congenic lines of chickens that were selected for high (H) and low (L) antibody response to SRBC and typed for B-G MHC genotypes (GTP) B13B13, B13B21, and B21B21, were immunized with SRBC or PBS.  Blood and spleens were processed for % B+, CD4+ and CD8+ lymphocytes by flow cytometry at 0, 3, 9 and  24 hr post-antigen (pAg) injection.  Plasma T3, T4 and ACTH were determined by RIA.  There were significant time pAg changes in cell percentages and hormone levels.  CD4+ cells in blood and spleen were significantly higher in the B21B21 than in the B13B13 GTP, with the B13B13 intermediate, suggesting that the MHC influence is through helper T-cell activity.  Plasma ACTH levels were highest in the B21B21 GTP and in SRBC-treated birds, but only in the L lines, resulting in significant GTP and Ag x line  interactions.  These results indicate the MHC and Ag-related hormone responses are influenced by genetic background.


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