U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Genomics and Improvement Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                                    Software
                People

                    Staff Listing
                                    Careers


        


                    AIP
                        Home
                                    About
                                    Publications
                                    Software
                                    People
                                    Collaborations
                                    Careers
                                    Centennial
                                    Contact
                                    Dairy industry links
                    DirectionsSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Genomics and Improvement Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- IACUC
- Home
- About
- Publications
- Software
- People
- Collaborations
- Careers
- Centennial
- Contact
- Dairy industry links
- Home
- Queries login
- News
- Animal Evaluation lists
- Genotype counts

Title:   Author  item
                                            Cole, Johnitem
                                            Null, Danielitem
                                            Vanraden, Paul
  Submitted to: Journal of Dairy Science
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 5/31/2016
                                    Publication  Date: 9/1/2016
                                    Citation: Cole, J.B., Null, D.J., Van Raden, P.M. 2016. Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. Journal of Dairy Science. 99(9):7274-7288.Interpretive Summary: Research using many DNA markers and fertility records identified several new genetic disorders in dairy cattle in recent years. This study examined the relationship of those disorders to traits of economic importance in US Ayrshire, Brown Swiss, Holstein, and Jersey cattle. Four of the 5 disorders originally shown to have undesirable effects on fertility also had significant associations with fertility in the current study. Effects were generally small even when statistically significant. Avoidance of carrier-to-carrier matings is adequate to minimize economic effects of these disorders, but new strategies will be needed as the number of disorders grows.
                                Technical Abstract: Phenotypes from the August 2015 US national genetic evaluation were used to compute phenotypic effects of cholesterol deficiency (CD) and 17 other recessive haplotypes in Ayrshire (AY; n=1), Brown Swiss (BS; n = 5), Holstein (HO; n = 10), and Jersey (JE; n = 2) cattle on milk, fat, and protein yields, somatic cell score (SCS), single-trait productive life (PL), daughter pregnancy rate (DPR), heifer conception rate (HCR), and cow conception rate (CCR). The form of the recessive CD haplotype (harmful or normal) was assigned based on genotype and pedigree analysis. A total of 30,928 HO were heterozygous for the harmful haplotype, 275 were homozygous for the harmful haplotype, 25,077 were heterozygous for the recessive haplotype but parental origin could not be determined, and 358 were homozygous for the recessive haplotype but parental origin could not be determined. Carriers of AH1 had higher milk yield than non-carriers. In BS, significant haplotype effects were BHD for increased fat and SCS; and BHM for increased milk, fat, and DPR, and decreased protein and HCR. A number of associations were noted for HO haplotypes, including increased protein, DPR, and CCR with HCD; HH0 with increased fat and CCR; HH1 with decreased DPR and CCR; HH2 with increased fat; HH3 with decreased protein and SCS; HH4 with increased DPR; and HHC with decreased fat. The JH1 haplotype was associated with increased fat production, and JH2 with lower CCR. Only 1 of the 5 haplotypes originally identified as having deleterious effects on fertility (HH1) also had a significant association with fertility in the current study. Effects of the recessive haplotypes studied were generally small even when significant. At present, avoidance of carrier-to-carrier matings probably is adequate to minimize economic effects of these recessives, but more sophisticated strategies will be needed as the number of known disorders grows.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov