U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Location Research Units
                        National Sedimentation Laboratory
                                    Natural Products Utilization Research Unit
                                    Water Quality and Ecology Research Unit
                                    Watershed Physical Processes Research UnitSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Research Project: Health-Promoting Bioactives and Biobased Pesticides from Medicinal and Herbal Crops Location:
                                Natural Products Utilization Research Title:   Author  item
                                            MORIMOTO, MASANORI - Kinki Universityitem
                                            Cantrell, Charlesitem
                                            KHAN, SHABANA - University Of Mississippiitem
                                            TEKWANI, BABU - University Of Mississippiitem
                                            Duke, Stephen
  Submitted to: Chemistry and Biodiversity
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 10/3/2017
                                    Publication  Date: 12/5/2017
                                    Citation: Morimoto, M., Cantrell, C.L., Khan, S., Tekwani, B.L., Duke, S.O. 2017. Antimalarial and antileishmanial activities of phytophenolics and their synthetic analogues. Chemistry and Biodiversity. DOI: 10.1002/cbdv.201700324.DOI: https://doi.org/10.1002/cbdv.201700324                                                              
                                Interpretive Summary: Plants produce various phenolics for protection from natural enemies, such as phytophagous insects, and environmental stresses such as severe sun light. The system is physiologically called a chemical defense system. In our research, the phytophenolic mono-/bi-benzene analogues were evaluated against protozoa causing the diseases leishmaniasis and malaria. Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against these two protozoal pathogens. 4,6-Dimethoxyaurone demonstrated the highest activity against protozoa causing the diseases leishmaniasis and malaria without undesired cytotoxicity. There was no correlation between antiprotozoal activities and previously evaluated insect antifeedant activity against common cutworms.
                                Technical Abstract: Thirty-seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, Leishmania donovani and Plasmodium falciparum (D6 and W2 clone), respectively. 4,6-Dimethoxyaurone demonstrated the highest activity with IC50 values of 13.2 uM and 16.9 uM against L. donovani and P. falciparum (W2 clone), respectively, without undesired cytotoxicity against VERO cells. The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumaranes and aurones, remained active. There was no correlation between antiprotozoal activities and previously evaluated insect antifeedant activity against common cutworms (Spodoptera litura). Flavonoids, including aurones, pterocarpanes, and lignans, structural analogues of coumaranes, are abundant in fruits and vegetables, so these phytophenolics may act as natural antiprotozoal agents in humans.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov