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 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





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Title:   Author  item
                                            MARGOLIS, LEE - Us Army Medical Research Instituteitem
                                            Cao, Jayitem
                                            Whigham Grendell, Leahitem
                                            MCCLUNG, JAMES - Us Army Medical Research Instituteitem
                                            Combs, Geralditem
                                            YOUNG, ANDREW - United States Army Medical Research Unititem
                                            PASIAKOS, STEFAN - Us Army Medical Research Institute
  Submitted to: Federation of American Societies for Experimental Biology Conference
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 11/3/2012
                                    Publication  Date: 4/9/2013
                                    Citation: Margolis, L.M., Cao, J.J., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2013. Dietary protein intake, energy deficit, and nitrogen balance in normal-weight adults: a randomized controlled. Federation of American Societies for Experimental Biology Conference. 27:1075.11.Interpretive Summary:
                                Technical Abstract: Consuming protein at levels higher than the recommended dietary allowance (RDA) may be metabolically advantageous for overweight and obese individuals attempting weight loss.  However, the dose-response characteristics that define the optimal level of dietary protein necessary to sustain measures of metabolic homeostasis during short-term energy deficit (ED) in normal-weight adults remain unclear.  Thirty-two men and 7 women participated in a 31-day randomized trial providing diets containing protein at either the RDA (0.8 g•kg-1•d-1), 2X-RDA (1.6 g•kg-1•d-1), or 3X-RDA (2.4 g•kg-1•d-1).  A weight maintenance (WM, days 1-10) period was followed by 21 days of ED (days 11-31); energy intake was restricted to 60% of daily requirements.  Nitrogen balance (NBAL) was assessed during WM (day 9) and throughout ED on days 14, 17, 24, and 30.  Independent of protein, NBAL (mgN·kg-1·d-1) was lower (P < 0.05) at the start of ED (day 14, -40 ± 5) compared to WM (day 9, -10 ± 5).  NBAL remained negative at the conclusion of ED (day 30) for RDA (-39 ± 8).  However, NBAL increased (P < 0.05) rapidly and was maintained at levels comparable to WM beginning on day 17 for 2X-RDA (0 ± 8), yet failed to achieve WM levels until day 30 (-7 ± 10) for 3X-RDA.  These data confirm that high protein diets conserve NBAL during short-term ED, but suggest no beneficial effect of protein at levels beyond 2X-RDA, as 3X-RDA failed to further enhance nitrogen adaptation.  

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