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ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Parasitic Diseases Laboratory Research Publications at this Location





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Title:   Author  item
                                            LORENZI, H - J Craig Venter Instituteitem
                                            KHAN, A - Washington University School Of Medicineitem
                                            BEHNKE, M - Washington University School Of Medicineitem
                                            LIU, L - University Of Georgiaitem
                                            NAMASIVAYAM, S - University Of Georgiaitem
                                            SESHADRI, S - University Of Torontoitem
                                            HADJITHOMAS, M - J Craig Venter Instituteitem
                                            KARAMYCHEVA, S - J Craig Venter Instituteitem
                                            PINNEY, D - University Of Pennsylvaniaitem
                                            BRUNK, B - University Of Pennsylvaniaitem
                                            AJIOKA, J - Cambridge Universityitem
                                            AZJENBERG, D - Hospital And University Center Of Limogesitem
                                            BOOTHROYD, J - Stanford Universityitem
                                            BOYLE, J - University Of Pittsburghitem
                                            DARDE, M - Hospital And University Center Of Limogesitem
                                            Dubey, Jitenderitem
                                            GRIGG, M - National Instiute Of Allergy And Infectious Diseases (NIAID, NIH)item
                                            HOWE, D - University Of Kentuckyitem
                                            KIM, K - Albert Einstein Medical Centeritem
                                            Rosenthal, Benjaminitem
                                            SAEIJ, J - Massachusetts Institute Of Technologyitem
                                            SU, C - University Of Tennesseeitem
                                            WHITE, M - University Of Californiaitem
                                            ZHU, X - Chinese Academy Of Agricultural Sciencesitem
                                            PARKINSON, J - University Of Torontoitem
                                            KISSINGER, J - University Of Georgiaitem
                                            ROOS, D - University Of Pennsylvaniaitem
                                            SIBLEY, L - Washington University School Of Medicine
  Submitted to: Nature Communications
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/9/2015
                                    Publication  Date: 1/7/2016
                                    Citation: Lorenzi, H., Khan, A., Behnke, M.S., Liu, L., Namasivayam, S., Seshadri, S., Hadjithomas, M., Karamycheva, S., Pinney, D., Brunk, B., Ajioka, J., Azjenberg, D., Boothroyd, J.C., Boyle, J., Darde, M.L., Dubey, J.P., Grigg, M., Howe, D., Kim, K., Rosenthal, B.M., Saeij, J., Su, C.L., White, M., Zhu, X.Q., Parkinson, J., Kissinger, J.C., Roos, D.S., Sibley, L.D. 2016. Comparative sequence analysis of Toxoplasma gondii reveals local genomic admixture drives concerted expansion and diversification of secreted pathogenesis determinants. Nature Communications. doi: 10.1038/ncomms10147.Interpretive Summary:
                                Technical Abstract: Toxoplasma gondii is among the most prevalent parasites worldwide,
infecting many wild and domestic animals and causing zoonotic infections in humans.  T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges.  To understand this diversity, we compared the genomes of 62 globally diverse T. gondii isolates to several closely related apicomplexan parasites. Our findings reveal that the tandem amplification and allelic diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites.  We further show that the unusual population structure of T. gondii is characterized by co-ancestry of large chromosomal haploblocks, suggesting that conserved inheritance of tandemly clustered determinants drives evolution of transmission, host range, and pathogenicity of apicomplexans.


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