U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Cao, Jay
  Submitted to: Journal of Federation of American Societies for Experimental Biology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 1/15/2015
                                    Publication  Date: 3/28/2015
                                    Citation: Cao, J.J. 2015. Increased circulating estradiol in mice fed a high-fat diet does not attenuate ovariectomy-induced bone structural deterioration [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:755.13.Interpretive Summary:
                                Technical Abstract: Ovariectomy-induced estrogen deficiency increases adiposity and induces substantial bone loss by increasing osteoclast activity. This study investigated whether obesity induced by a high-fat diet alter circulating estradiol levels, mitigates or exacerbates bone structure deterioration, and changes markers of bone resorption and formation in ovariectomized mice. Thirty-six female C57BL/6 mice at 4-mo-old were either sham-operated or ovariectomized and fed either a normal-fat diet (10% kcal as fat) or a high-fat diet (45% kcal as fat with extra fat from lard) ad libitum for 12 wks. Ovariectomy resulted in increased body weight, serum tartrate-resistant acid phosphatase level, and expression of cathepsin K in bone; decreased serum estradiol level; and induced significant bone loss by decreasing BV/TV, Conn.D, Tb.N, and Tb.Th while increasing Tb.Sp and SMI (P < 0.05). High-fat diet increased body weight in ovariectomized mice and slightly decreased BV/TV (P = 0.08) and SMI (P = 0.09) compared to normal-fat diet feeding. Despite having similar serum estradiol levels and higher body weight, ovariectomized mice consuming the high-fat diet had lower BV/TV, Conn.D, Tb.N, Tb.Th and greater SMI and Tb.Sp than sham mice fed the normal-fat diet. These findings indicate that increased body weight and elevated serum estradiol in ovariectomized mice in response to a high-fat diet does not protect ovariectomy-induced bone loss.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov