U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Announcements
                        ABBL Journal Club
                    USDA Civil Rights Policy StatementSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            XU, SHOUZHEN - Qingdao Agricultural Universityitem
                                            LEE, SUNG HYEN - Korean Rural Development Administrationitem
                                            Lillehoj, Hyunitem
                                            HONG, YEONG HO - Chung-Ang Universityitem
                                            BRAVO, DAVID - Pancosma Sa
  Submitted to: Research in Veterinary Science
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 12/3/2014
                                    Publication  Date: 12/16/2014
                                    Publication URL: http://handle.nal.usda.gov/10113/61649Citation: Xu, S., Lee, S., Lillehoj, H.S., Hong, Y., Bravo, D. 2014. Effects of dietary selenium on host response to necrotic enteritis in young broilers. Research in Veterinary Science. 98:66-73.Interpretive Summary: There is an increasing interest to develop a nutritional approach to enhance gut health and to decrease negative consequences of enteric infections due to strict control of antibiotics in animal production.  In this paper, ARS scientists collaborated with scientists in China and an industry partner in Switzerland to explore the use of selenium as a dietary prevention strategy to reduce gut damage caused by enteric pathogens.  Dietary supplementation of young broiler chickens at birth with a new organic selenium formulation called B-Traxim showed beneficial effects and reduced ill effects of coccidiosis and necrotic enteritis.  Furthermore, dietary selenium starting from hatch stimulated intestinal parasite-induced secretion of cytokines involved in innate immune response.  Therefore, this study demonstrates beneficial effects of dietary selenium as a method to reduce gut damage caused by intestinal parasites and gut bacteria.
                                Technical Abstract: The effects of dietary supplementation of young broiler chickens with a new organic selenium (Se) formulation, B-Traxim Se, on the host response to experimental necrotic enteritis (NE) were studied. Broiler chickens treated with three Se doses (0.25, 0.50, 1.00 mg/kg) from hatch were orally challenged with Eimeria maxima at 14 days of age followed by Clostridium perfringens 4 days later to induce experimental disease. Body weight gain, intestinal lesion scores, fecal oocyst shedding, serum antibody levels against C. perfringens a-toxin and NetB toxin, and the levels of transcript for pro-inflammatory cytokines and avian ß-defensins (AvBD) in the intestine and spleen were measured as parameters of host protection against NE. Chickens fed with 0.50 mg/kg Se showed significantly increased body weight gain and serum antibody levels against NetB toxin, and significantly reduced intestinal lesions compared to chickens without the SE supplementation. However, there were no significant differences in Eimeria oocyst shedding between the Se-supplemented and non-supplemented groups. The level of transcript for IL-1ß, IL-6, IL-8, iNOS, LITAF, TNFSF15, AvBD6, AvBD8, and AvBD13 were increased in the intestine and spleen of at least one of the three Se-supplemented groups compared with the non-supplemented group. These results suggest that dietary supplementation of young broilers with B-Traxim Se might be beneficial to reduce the negative consequence of avian NE and to enhance host protective immune responses against C. perfringens.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov