U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Genomics and Improvement Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                                    Software
                People

                    Staff Listing
                                    Careers


        


                    AIP
                        Home
                                    About
                                    Publications
                                    Software
                                    People
                                    Collaborations
                                    Careers
                                    Centennial
                                    Contact
                                    Dairy industry links
                    DirectionsSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Genomics and Improvement Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- IACUC
- Home
- About
- Publications
- Software
- People
- Collaborations
- Careers
- Centennial
- Contact
- Dairy industry links
- Home
- Queries login
- News
- Animal Evaluation lists
- Genotype counts

Title:   Author  item
                                            DIKMEN, SERDAL - Uludag Universityitem
                                            WANG, XIAN-ZHONG - Southwest Universityitem
                                            ORTEGA, M. SOFIA - University Of Floridaitem
                                            Null, Danielitem
                                            Cole, Johnitem
                                            HANSEN, PETER - University Of Florida
  Submitted to: Journal of Animal Breeding and Genetics
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 4/21/2015
                                    Publication  Date: 7/21/2015
                                    Citation: Dikmen, S., Wang, X., Ortega, M., Null, D.J., Cole, J.B., Hansen, P.J. 2015. Single nucleotide polymorphisms associated with thermoregulation in lactating dairy cows exposed to heat stress. Journal of Animal Breeding and Genetics. 132(6):409-419.Interpretive Summary: Dairy cows with increased rectal temperature during heat stress experience lower milk yield and reduced fertility. Because rectal temperature during heat stress is heritable, genetic selection for regulation of body temperature should reduce the effects of heat stress on production and reproduction.  The goals of this study were to validate the relationships between heat tolerance and DNA markers previously related to resistance to heat stress, as well as to identify new DNA markers related to resistance to heat stress. Thermotolerance was studied by measuring rectal temperature (a direct measurement of body temperature regulation), respiration rate (an indirect measurement of body temperature regulation), and sweating rate (the major evaporative cooling mechanism in cattle) in 455 lactating Holstein cows during the hottest part of the day in summer. DNA markers previously related to heat tolerance on chromosomes 4, 6, and 24 were related to rectal temperature, regions of chromosomes 6 and 24 were associated with respiration rate, and regions on chromosomes 5, 24, and 29 were associated with sweating rate. New markers were identified for rectal temperature (n=12), respiration rate (n=8), and sweating rate (n=3), including markers in the CAST and PGR genes related to rectal temperature, the ARPL61P and TSHB genes related to respiration rate, and the SERPINE2 gene, related to sweating rate. These genetic markers may prove useful in genetic selection for heat tolerance in Holstein cattle.
                                Technical Abstract: Dairy cows with increased rectal temperature during heat stress experience lower milk yield and fertility. Given that rectal temperature during heat stress is heritable in dairy cattle, genetic selection for regulation of body temperature should reduce effects of heat stress on production.  One goal of the study was to validate the relationship between genotype and heat tolerance for SNPs previously related to resistance to heat stress. A second goal was to identify new candidate gene SNPs related to resistance to heat stress.  Thermotolerance was assessed in 435-455 lactating Holstein cows during the hottest part of the day in summer by measuring rectal temperature (a direct measurement of body temperature regulation), respiration rate (an indirect measurement of body temperature regulation) and sweating rate (the major evaporative cooling mechanism in cattle).  Thermotolerance was related to genotype for 19 SNPs previously related to rectal temperature from a genome-wide analysis study (GWAS), 4 SNPs previously related to change in milk yield during heat stress from GWAS, 2 candidate gene SNPs previously related to rectal temperature and respiration rate during heat stress (ATPA1A and HSPA1A/HSPA1B) and 66 SNPs in candidate genes that were previously related to reproduction, production or health traits in Holsteins. For SNPs previously related to heat tolerance in GWAS, regions of BTA4, BTA6 and BTA24 were related to rectal temperature, regions of BTA6 and BTA24 were associated with respiration rate and regions on BTA5, BTA24 and BTA29 were associated with sweating rate.  New candidate gene SNPs were identified for rectal temperature (n=12), respiration rate (n=8), and sweating rate (n=3). Among these SNPs were ones for CAST and PGR, related to rectal temperature, ARPL61P and TSHB, related to respiration rate, and S SERPINE2, related to sweating rate. These genetic markers may prove useful in genetic selection for heat tolerance in Holstein cattle.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov