U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Parasitic Diseases Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Resources
                        Our ScientistsSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Parasitic Diseases Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            HOON-HANKS, L - Colorado State Universityitem
                                            REGAN, D - Colorado State Universityitem
                                            Dubey, Jitenderitem
                                            PORTER, M - Vca All Pets Animal Hospitalitem
                                            DUNCAN, C - Colorado State University
  Submitted to: Journal of Veterinary Diagnostic Investigation
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/1/2013
                                    Publication  Date: 12/1/2013
                                    Citation: Hoon-Hanks, L., Regan, D., Dubey, J.P., Porter, M., Duncan, C. 2013. Hepatic neosporosis in a dog treated for pemphigus foliaceus. Journal of Veterinary Diagnostic Investigation. 25:807-810.Interpretive Summary: Toxoplasmosis and neosporosis are single celled parastic infections caused by Toxoplasma gondii and Neospora caninum, respectively. Until recently these parasites were considered one species. In the present papers authors describe a case of severe liver disease in a dog due to neosporosis and describe differential diagnosis. The results will be useful to veterinarians, and parasitologists.
                                Technical Abstract: A 4 year old, female, spayed Border Collie was presented for progressive lethargy, inappetence, and weakness of four days duration. The animal had been diagnosed with pemphigus foliaceus three months prior and was receiving combination immunosuppressive therapy. Serum biochemistry revealed severely elevated liver enzymes and bilirubin, and humane euthanasia was elected. Gross postmortem examination revealed a diffusely pale tan to slightly yellow, enlarged, markedly friable liver with an enhanced reticular pattern. Histologically, the hepatic changes consisted of multifocal to coalescing areas of severe vacuolar degeneration, numerous, coalescing foci of hepatocellular necrosis, and myriad intra- and extra-cellular protozoa that reacted immunohistochemically with polyclonal antibodies to Neospora c aninum, and not Toxoplasma gondii. Neosporosis in this case is thought to be due to reactivation of latent N. caninum occurring with the administration of glucocorticoid therapy. Severe complication in the present case highlights the importance of early detection and mitigation of common infections in immunosuppressed animals.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov