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Title:   Author  item
                                            GREEN, ADRIAN - University Of Californiaitem
                                            GRAHAM, JAMES - University Of Californiaitem
                                            GONZALEZ, EDUARDO - University Of Californiaitem
                                            LAFRANO, MICHAEL - University Of Californiaitem
                                            HE, GUOCHUN - University Of Californiaitem
                                            PERTOPOULOU, SYRAGO-STYLIANI - California Environmental Protection Agencyitem
                                            PARK, JUNE-SOO - California Environmental Protection Agencyitem
                                            DENISON, MICHAEL - University Of Californiaitem
                                            Newman, John
  Submitted to: Reproductive Toxicology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/12/2016
                                    Publication  Date: 7/12/2016
                                    Citation: Green, A.J., Graham, J.L., Gonzalez, E.A., Lafrano, M.R., He, G., Pertopoulou, S.E., Park, J., Denison, M., Newman, J.W. 2016. Perinatal exposure to the flame retardant triphenyl phosphate accelerates the onset of type 2 diabetes and causes adipose accumulation in UCD-type 2 diabetes mellitus rats. Reproductive Toxicology. pii: S0890-6238(16)30266-0. doi: 10.1016/j.reprotox.2016.07.009.Interpretive Summary: Triphenyl phosphate (TPP) is an additive used globally to in furniture, foams, and electronics products either as a flame retardant or plasticizer and is found in household dust.  Reportedly, exposing mice to a flame retardant that contained this compound from mid-gestation to weaning caused obesity and changes in glucose intolerance, hallmarks of type 2 diabetes mellitus (T2DM). In this study, we administered a low dose of TPP to UC Davis type 2 diabetes mellitus-prone (UCD-T2DM) rats from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats and male rats up to 6 months to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPP exposure increased body and fat weight in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Male rats with perinatal TPP exposure had an accelerated onset of T2DM and had changes in non-esterified fatty acid profiles consistent with changes in lipid metabolism previously reported with diabetes. Together, these observations suggest that perinatal exposure to TPP causes obesity in male and female UCD-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.
                                Technical Abstract: Triphenyl phosphate (TPP) is an additive used globally to in furniture, foams, and electronics products either as a flame retardant or plasticizer and is found in household dust. We administered TPP from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats and male rats up to 6 months to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPP exposure increased body and fat weight in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Male rats with perinatal TPP exposure had an accelerated onset of T2DM and had increased total saturated-, total mono-unsaturated- and total non-esterified- fasting fatty acids, including total saturated and monounsaturated fatty acids. These observations suggest that perinatal exposure to TPP causes obesity in male and female UCD-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.


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