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ARS Home Midwest Area Ames, Iowa National Animal Disease Center Infectious Bacterial Diseases Research Research Publications at this Location





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Title:   Author  item
                                            MAGGIOLI, MAYARA - Iowa State Universityitem
                                            Palmer, Mitchellitem
                                            Thacker, Tyleritem
                                            VORDERMEIER, MARTIN - Animal & Plant Health Agency Aphaitem
                                            MCGILL, JODI - Kansas State Universityitem
                                            LARSEN, MICHELLE - Albert Einstein College Of Medicineitem
                                            JACOBS, WILLIAM - Albert Einstein College Of Medicineitem
                                            Waters, Wade
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 10/25/2015
                                    Publication  Date: 11/22/2015
                                    Citation: Maggioli, M.F., Palmer, M.V., Thacker, T.C., Vordermeier, M., Mcgill, J., Larsen, M., Jacobs, W., Waters, W.R. 2015. Polyfunctional cytokine production by central memory T cells from cattle in response to Mycobacterium bovis infection and BCG vaccination. Meeting Abstract. page 33.Interpretive Summary:
                                Technical Abstract: Polyfunctional T cells simultaneously produce IFN-gamma, IL-2 and TNF-alpha and play relevant roles in several chronic infections, including TB. Mycobacterium bovis infection of cattle elicits ex vivo polyfunctional T cell responses. Vaccine-elicited IFN-gamma Tcm (CD4+ CD45RO+ CCR7+) responses correlate to protection in cattle. The objective was to assess polyfunctional Tcm responses to vaccination with BCG or BCG mutants and subsequent M. bovis challenge in cattle. BCG evoked polyfunctional Tcm to PPD and Ag85A/TB10.4. After challenge, TNF-alpha/IFN-gamma Tcm responses to PPD, Ag85A/TB10.4 or ESAT-6:CFP10 were greater in non-vaccinates in comparison to vaccinates. Both vaccines showed similar protection; however, vaccinated animals that were M. bovis culture negative had lower TNF-alpha/IFN-gamma polyfunctional Tcm responses to ESAT-6:CFP10 3wpi than did culture positive vaccinates. In conclusion, BCG vaccination elicited Tcm polyfunctionality, mainly TNF-alpha/IFN-gamma. Dampened TNF-alpha/IFN-gamma Tcm responses after challenge may indicate enhanced pathogen control and correlate with vaccine elicited protection.


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