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Title:   Author  item
                                            SUN, YE - National University Of Singaporeitem
                                            KOH, HIROMI - National University Of Singaporeitem
                                            CHOI, HYUNGWON - National University Of Singaporeitem
                                            KOH, WOON-PUAY - National University Of Singaporeitem
                                            YUAN, JIAN-MIN - University Of Pittsburghitem
                                            Newman, Johnitem
                                            SU, JIN - National University Of Singaporeitem
                                            FANG, JINLING - National University Of Singaporeitem
                                            ONG, CHOON NAM - National University Of Singaporeitem
                                            VAN DAM, ROB - National University Of Singapore
  Submitted to: Journal of Lipid Research
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 5/24/2016
                                    Publication  Date: 7/20/2016
                                    Citation: Sun, Y., Koh, H.W., Choi, H., Koh, W., Yuan, J., Newman, J.W., Su, J., Fang, J., Ong, C., Van Dam, R.M. 2016. Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese health study. Journal of Lipid Research. 57:1300-1307.Interpretive Summary: This study examined the prospective association between the risk of acute myocardial infarction (AMI) and both plasma fatty acids (FAs) and oxylipin mediators of inflammation in a Singapore Chinese population.  As a part of the Singapore Chinese Health Study, a nested case-control study was conducted with 744 incident AMI cases and 744 matched controls aged 47-83 years. Nineteen plasma FAs and 12 oxylipins were quantified using mass spectrometry. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed.  Plasma concentrations of long-chain n-3 FAs like those derived from cold water fatty fish (OR=0.67 per SD increase, 95% CI: 0.53-0.84, p<0.001) and the saturated fatty acid stearic acid (OR=0.65, 95% CI: 0.44-0.97, p=0.03) were inversely associated with AMI risk, whereas the polyunsaturated n6 fatty acid arachidonic acid (AA) was positively associated with AMI risk (OR=1.25, 95% CI: 1.03-1.52, p=0.02) in the multivariable model after adjustment for other the behavior of other FAs. Further adjustment for oxylipins did not substantially change these associations. Unexpectedly, a significant inverse association was observed between the AA-derived oxylipin thromboxane B2 (TXB2), an important marker of platelet function, and AMI risk (OR=0.81, 95% CI: 0.71-0.93, p=0.003).  These data indicate that the risk of AMI is influenced by variation in plasma fatty acids in this Chinese population, but that the examined oxylipins were not key mediators of the FAs-AMI relation.
                                Technical Abstract: Objective: We aimed to examine the prospective association between plasma fatty acids (FAs), oxylipins and risk of acute myocardial infarction (AMI) in a Singapore Chinese population.
Methods: A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47-83 years was conducted within the Singapore Chinese Health Study. Nineteen plasma FAs and 12 oxylipins were quantified using mass spectrometry. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed.
Results: Long-chain n-3 FAs (OR=0.67 per SD increase, 95% CI: 0.53-0.84, p<0.001) and stearic acid (OR=0.65, 95% CI: 0.44-0.97, p=0.03) were inversely associated with AMI risk, whereas arachidonic acid (AA) was positively associated with AMI risk (OR=1.25, 95% CI: 1.03-1.52, p=0.02) in the multivariable model with adjustment for other FA. Further adjustment for oxylipins did not substantially change these associations. A significant inverse association was observed between AA-derived oxylipin thromboxane B2 (TXB2) and AMI risk (OR=0.81, 95% CI: 0.71-0.93, p=0.003).
Conclusions: The risk of AMI is influenced by variation in plasma fatty acids in this Chinese population. Our results do not suggest that the examined oxylipins were key mediators of the FAs-AMI relation.


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