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Title:   Author  item
                                            Brunelle, Brianitem
                                            Bearson, Bradley

                                                         - *Brad*item
                                            Bearson, Shawn
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 10/19/2015
                                    Publication  Date: 10/27/2015
                                    Citation: Brunelle, B.W., Bearson, B.L., Bearson, S.M. 2015. Antibiotic exposure can induce various bacterial virulence phenotypes in multidrug-resistant Salmonella enterica serovar Typhimurium [abstract]. In: Proceedings of 14th Annual Great Plains Infectious Disease Meeting, November 6-7, 2015, Lawrence, Kansas. p. 38.Interpretive Summary:
                                Technical Abstract: Salmonella is one of the most prevalent bacterial foodborne diseases in the United States and causes an estimated 1 million human cases every year.  Multidrug-resistant (MDR) Salmonella has emerged as a public health issue as it has been associated with increased morbidity in humans and mortality in livestock compared to antibiotic sensitive isolates.  It is known that antibiotics can have unintended consequences on bacteria, and the goal of my research has been to characterize some of these collateral effects in MDR Salmonella Typhimurium.  We have found that various antibiotics can enhance a variety of virulence phenotypes in MDR S. Typhimurium, such as inducing cellular invasion, increasing antibiotic resistance, and stimulating horizontal gene transfer.  These factors may underlie some of the clinical observations associated with MDR Salmonella virulence.


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