U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Announcements
                        ABBL Journal Club
                    USDA Civil Rights Policy StatementSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            KIM, WOO - US Department Of Agriculture (USDA)item
                                            FERNANDEZ, CHERRY - Gyeongsang National Universityitem
                                            Lillehoj, Hyunitem
                                            MIN, WONGI - Gyeongsang National University
  Submitted to: American Association for Immunology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/3/2015
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Although IL-17 cytokines play critical roles in host defense immunity, dysregulated expression of these cytokines is associated with inflammation and autoimmune diseases.  Riemerella anatipestifer (R. anatipestifer) is the most important infectious bacterium in the duck industry, and can cause up to a 75% mortality rate in ducks. Interestingly, not all avian species are equally susceptible to R. anatipestifer infection.  In this study, ducks exhibited increased susceptibility to R. anatipestifer infection compared to chickens, as determined by mortality rate and bacterial burden.  Comparative expression analyses of immune- related genes in R. anatipestifer-infected tissues and R. anatipestifer-stimulated splenic lymphocytes obtained from both species revealed that IL-17A is strongly associated with Riemerella infection in only ducks.  Moreover, marked increases in the expression of IL-6, but not TGF-ß, was associated with Th17 cell differentiation in tissues from ducks, which were infected with R. anatipestifer.  However, this did not happen in the R. anatipestifer-infected chickens.  Furthermore, treatment with 3,3’-diindolylmethane (DIM) and berberine (BBR) ameliorated the detrimental effects of R. anatipestifer infection, as determined by decreases in mortality rate and bacterial burden, as well as the downregulation of IL-17A and IL-6 mRNA expression.  Our results indicate that IL-17A upregulation may influence disease susceptibility to R. anatipestifer infection in ducks.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov