U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Announcements
                        ABBL Journal Club
                    USDA Civil Rights Policy StatementSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            JANG, SEUNG - US Department Of Agriculture (USDA)item
                                            Lillehoj, Hyunitem
                                            Lee, Sungitem
                                            LEE, KYUNG - Animal, Plant And Fisheries Quarantine And Inspection Agency (QIA)item
                                            LILLEHOJ, ERIK - University Of Marylanditem
                                            HONG, YEONG - Chung-Ang Universityitem
                                            AN, DONG JUNE - Animal, Plant And Fisheries Quarantine And Inspection Agency (QIA)item
                                            JEONG, HYE YOUNG - Animal, Plant And Fisheries Quarantine And Inspection Agency (QIA)item
                                            CHUN, JI EUN - Animal, Plant And Fisheries Quarantine And Inspection Agency (QIA)
  Submitted to: Avian Diseases
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 12/24/2013
                                    Publication  Date: 12/30/2013
                                    Publication URL: http://handle.nal.usda.gov/10113/59001Citation: Jang, S.I., Lillehoj, H.S., Lee, S.H., Lee, K.W., Lillehoj, E.P., Hong, Y.H., An, D., Jeong, H., Chun, J. 2013. Relative disease susceptibility and clostridial toxin antibody responses in three commercial broiler lines co-infected with Clostridium perfringens and Eimeria maxima using an experimental model of necrotic enteritis. Avian Diseases. 57(3):684-7.Interpretive Summary: Necrotic enteritis (NE) is an important intestinal infectious disease in commercial poultry production with substantial mortality. The disease causing agent of NE is an intestinal bacteria, Clostridium (C.) perfringens, which is transmitted by the fecal-oral route as well as through contaminated feed, water, housing structures, and insects. The worldwide incidence of C. perfringens-associated NE has significantly increased in the last decade, primarily related to the decreasing use of in-feed antibiotics as growth promoters and antimicrobials.  In this paper, ARS scientists collaborated with scientists from the Korean government and a university to compare NE disease susceptibility among three different commercial chicken breeds. The results showed that commercial broiler chickens from different breeds demonstrate different clinical signs, which include NE-induced body weight loss and gut lesions. These results will help field veterinarians to understand the role of the host’s genetic background in determining disease susceptibility to C. perfringens.
                                Technical Abstract: Necrotic enteritis is an enteric disease of poultry resulting from infection by Clostridium perfringens with co-infection by Eimeria spp. constituting a major risk factor for disease pathogenesis. This study compared three commercial broiler chicken lines using an experimental model of necrotic enteritis. Day-old male Cobb, Ross, and Hubbard broilers were orally infected with viable C. perfringens and E. maxima and fed a high protein diet to promote the development of experimental disease. Body weight loss, intestinal lesions, and serum antibody levels against a-toxin and necrotic enteritis B-like (NetB) toxin were measured as parameters of disease susceptibility and host immune response. Cobb chickens exhibited increased body weight loss compared with Ross and Hubbard breeds, and greater gut lesion severity compared with Ross chickens. NetB antibody levels were greater in Cobb chickens compared with the Ross or Hubbard groups. These results suggest that Cobb chickens may be more susceptible to necrotic enteritis in the field compared with the Ross and Hubbard lines.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov