U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Infectious Bacterial Diseases Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Infectious Bacterial Diseases Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Waters, Wadeitem
                                            Palmer, Mitchell
  Submitted to: ILAR Journal
                                    Publication Type: Review Article
                                    Publication Acceptance Date: 1/12/2015
                                    Publication  Date: 5/19/2015
                                    Publication URL: https://handle.nal.usda.gov/10113/60890Citation: Waters, W.R., Palmer, M.V. 2015. Mycobacterium bovis infection of cattle and white-tailed deer:  Translational research of relevance to human tuberculosis. ILAR Journal. 56(1):26-43.Interpretive Summary: Despite highly successful eradication efforts in several countries, tuberculosis of cattle remains a serious health concern worldwide. In addition, an outbreak of tuberculosis in white-tailed deer in Michigan and continued importation of tuberculous cattle from Mexico have seriously hindered eradication efforts within the United States. Without new strategies, eradication and control of bovine tuberculosis will be impossible. Thus, improved techniques for control, such as better diagnostic tests and vaccines, are needed for prevention of tuberculosis in cattle. In this article, the natural history of bovine tuberculosis in cattle and deer as well as immune mechanisms associated with bovine tuberculosis infection and vaccination are reviewed and compared to similar studies on human tuberculosis. This article provides a summary on the current knowledge of bovine tuberculosis research and its relevance to human tuberculosis. Additionally, it provides insight into the “One Health” principle using bovine tuberculosis as a primary example for this approach.
                                Technical Abstract: Tuberculosis (TB) is a premier example of a disease complex with pathogens primarily affecting humans (i.e., Mycobacterium tuberculosis) or livestock and wildlife (i.e., Mycobacterium bovis) and with a long history of inclusive collaborations between physicians and veterinarians. Advances with the study of bovine TB have been applied to human TB, and vice versa. For instance, landmark discoveries on the use of Koch’s tuberculin and interferon-gamma release assays for diagnostic purposes as well as Calmette and Guerin’s attenuated M. bovis strain as a vaccine were first evaluated in cattle for control of bovine TB prior to wide-scale use in humans. Likewise, recent discoveries on the role of effector/memory T cell subsets and polyfunctional T cells in the immune response to human TB, particularly as related to vaccine efficacy, have paved the way for similar studies in cattle. Over the past 15 years, substantial funding for human TB vaccine development has led to the emergence of multiple promising vaccines now in human clinical trials; of which, several are being tested for immunogenicity and efficacy in cattle. Also, the development of population-based vaccination strategies for control of M. bovis infection in wildlife reservoirs (e.g., white-tailed deer in Michigan, USA) will undoubtedly have an impact on our understanding of herd immunity with relevance to the control of both bovine and human TB in high prevalence regions of the world. Thus, the one health approach to research on TB is mutually beneficial for our understanding and control of TB in humans, livestock, and wildlife.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov