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ARS Home Plains Area Lubbock, Texas Cropping Systems Research Laboratory Livestock Issues Research Research Publications at this Location





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Title:   Author  item
                                            D'OREY BRANCO, RUI - Texas A&M Universityitem
                                            NEUENDORFF, DON - Texas A&M Universityitem
                                            SCHMIDT, SARAH - Texas A&M Universityitem
                                            Sanchez, Nicoleitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            WELSH, THOMAS - Texas A&M Universityitem
                                            RANDEL, RONALD - Texas A&M University
  Submitted to: Journal of Animal Science
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 1/8/2016
                                    Publication  Date: 3/4/2016
                                    Citation: D'Orey Branco, R.A., Neuendorff, D.A., Schmidt, S.E., Sanchez, N.C., Carroll, J.A., Welsh, T.H., Randel, R.D. 2016. Influence of prenatal stress on insulin response to a glucose challenge in yearling Brahman bulls. Journal of Animal Science. 94:, No.Supplement 1, pg.33.Interpretive Summary:
                                Technical Abstract: We hypothesized that stressing cows during gestation (prenatal stress, PNS) would increase the insulin
sensitivity of their progeny. Progeny of PNS cows subjected to transportation for 2 hour periods on days 60, 80,
100, 120 and 140 of gestation were compared with progeny of nontransported controls (CON). Yearling
CON (n= 12) and PNS (n= 12) bulls with similar BW (298.50 +/- 5.95 kg) and temperament were selected
for the study. Following 12 hours off feed the bulls were fitted with jugular vein catheters and placed in
individual stanchions. After a 2 hour acclimation period, bulls were administered a glucose tolerance test (0.5
mL/kg body weight of 50% dextrose solution). Blood samples were collected at 10 minute intervals for 40 minutes and
then at 20 minute intervals until 180 minutes postchallenge. Serum concentrations of glucose and insulin were
determined by enzymatic assay and ELISA, respectively. Data were analyzed using mixed models
procedures of SAS with repeated measures. Basal concentrations of insulin (P< 0.53) and
glucose (P< 0.35) were not affected by PNS. Serum insulin increased in both CON and PNS bulls within
10 minutes of glucose administration with a tendency for PNS bulls to reach the insulin peak earlier (P= 0.09)
and return to basal insulin earlier (P< 0.01) than CON bulls. Glucose concentration was not affected by
treatment (P= 0.14) or by the interaction of treatment by time (P= 0.53). Time to reach basal glucose
concentration was unaffected by treatment (P= 0.73). The area under the response curve was greater for
glucose (P< 0.01) and lesser for insulin (P< 0.01) in the PNS bulls compared to CON bulls. The insulin to
glucose ratio was lesser (P<0.06) in PNS bulls. These results support our hypothesis that PNS increased
sensitivity to insulin.


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