U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Announcements
                        ABBL Journal Club
                    USDA Civil Rights Policy StatementSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            LEE, KYUNG - US Department Of Agriculture (USDA)item
                                            Lillehoj, Hyunitem
                                            JANG, SEUNG - US Department Of Agriculture (USDA)item
                                            Lee, Sung
  Submitted to: Korean Journal of Poultry Science
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/30/2014
                                    Publication  Date: 6/1/2013
                                    Citation: Lee, K.W., Lillehoj, H.S., Jang, S.J., Lee, S.H. 2013. Effects of various field coccidiosis control programs on host innate and adaptive immunity in commercial broiler chickens. Korean Journal of Poultry Science. 39(1). DOI: 10.5536/KJPS.2012.39.1.017.Interpretive Summary: Avian coccidiosis is major parasitic disease of high economic concern to poultry industry worldwide. The estimated economic loss for avian coccidiosis is estimated to be more than $3 billion worldwide. It has been a common practice to implement vaccination against coccidiosis or to use drugs to inhibit parasitic growth by poultry industry and  it is important to gain better understanding of how these treatments affect host ability to make immune response to field pathogens. In this study ARS scientists collaborated with scientists at private companies to investigate if different type of coccidiosis control programs commonly used in field poultry production modulate various systemic immune parameters of poultry host. The results showed that the type of drug control program influenced various aspects of host immune cells and their function and these effects can affect poultry health and productivity. This finding will help field veterinarians to develop better disease control strategy.
                                Technical Abstract: Coccidiosis control programs such as vaccines or in-feed anticoccidials are commonly practiced in poultry industry to improve growth performance and health of commercial broiler chickens.  In this study, we assessed the effects of various coccidiosis control programs (e.g., in ovo vaccination, synthetic chemicals, and antibiotic ionophores) on immune status of broiler chickens vaccinated against infectious bronchitis virus and Newcastle disease virus (ND) and raised on an Eimeria-contaminated used litter. In general, the levels of a-1-acid glycoprotein, an acute phase protein, were altered by the treatments when measured at 34 days of age. Splenocyte subpopulations and serum antibody titers against ND were altered by various coccidiosis control programs.  In-ovo-vaccinated chickens exhibited highest mitogenic response when their spleen cells were stimulated with concanavalin A (Con A) at 7 days of age. It is clear from this study that the type of coccidiosis control program influenced various aspects of innate and adaptive immune parameters of broiler chickens. Further studies will be necessary to delineate the underlying relationship between the type of coccidiosis control program and host immune system and to understand the role of other external environmental factors such as gut microbiota on host-pathogen interaction in various disease control programs.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov