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Title:   Author  item
                                            HALLENBORG, PHILIP - University Of Copenhagenitem
                                            PETERSEN, RASMUS - University Of Copenhagenitem
                                            Newman, Johnitem
                                            MADSEN, LLISE - National Institute Of Nutrition And Seafood Research, Nifesitem
                                            KRISTIANSEN, KARSTEN - University Of Copenhagen
  Submitted to: Cell Metabolism
                                    Publication Type: Review Article
                                    Publication Acceptance Date: 11/10/2015
                                    Publication  Date: 12/15/2015
                                    Citation: Hallenborg, P., Petersen, R.K., Newman, J.W., Madsen, L., Kristiansen, K. 2015. The elusive endogenous adipogenic PPARy agonists: lining up the suspects. Cell Metabolism. 61:149-162. doi: 10.1016/j.plipres.2015.11.002.Interpretive Summary: The peroxisome proliferator-activated receptor gamma (PPARgamma) is a structure which interacts with genes in the nucleus of adipose cells which are regulated by binding small molecules (i.e. ligands).  Ligand binding to PPARgamma activates this receptor early in adipogenesis, the process by which immature adipose cells gain the ability to store fat, and  this event is thought to be critical for this change in tissue function. Although several fatty acids and their derivatives are known to bind and activate PPARgamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation in a living organism are still a matter of debate. Here we review recent data on proteins involved in ligand-production as well as possible endogenous, adipogenic agonists.
                                Technical Abstract: Centrally placed in the development of adipocytes is the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma). Ligand-mediated activation of PPARgamma happens early during adipogenesis and is thought to prime adipose conversion. Although several fatty acids and their derivatives are known to bind and activate PPARgamma, the identity of the ligand(s) responsible for initiating adipocyte differentiation is still a matter of debate. Here we review recent data on proteins involved in ligand-production as well as possible endogenous, adipogenic agonists.


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