U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Location Research Units
                        National Sedimentation Laboratory
                                    Natural Products Utilization Research Unit
                                    Water Quality and Ecology Research Unit
                                    Watershed Physical Processes Research UnitSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            DONEGA, MATEUS - Universidad De Sao Pauloitem
                                            MELLO, SIMONE - University Of Mississippiitem
                                            MORAES, RITA - University Of Mississippiitem
                                            JAIN, SURENDRA - University Of Mississippiitem
                                            TEKWANI, BABU - University Of Mississippiitem
                                            Cantrell, Charles
  Submitted to: Planta Medica
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 9/18/2014
                                    Publication  Date: 10/23/2014
                                    Publication URL: http://handle.nal.usda.gov/10113/62279Citation: Donega, M., Mello, S.C., Moraes, R.M., Jain, S.K., Tekwani, B., Cantrell, C.L. 2014. Pharmacological activities of cilantro’s aliphatic Aldehydes against leishmania donovani. Planta Medica. 80:1706-1711.Interpretive Summary: Leishmaniasis is a chronic infectious disease caused by different Leishmania species. Global occurrences of this disease are primarily limited to tropical and subtropical regions. Treatments are available; however, patients complain of side effects. Different species of plants have been screened as a potential source of new drugs against leishmaniasis. In this study, we investigated the antileishmanial activity of cilantro essential oil, and its main aliphatic aldehyde components.  Cilantro’s essential oil achieved 98% inhibition of Leishmani donovani promastigotes. The aliphatic aldehydes, are effective inhibitors of in vitro cultures of L. donovani promastigotes and axenic amastigotes. The results showed that essential oil of C. sativum leaves and its major compounds may represent a valuable source of new drugs against Leishmaniasis.
                                Technical Abstract: Leishmaniasis is a chronic infectious disease caused by different Leishmania species. Global occurrences of this disease are primarily limited to tropical and subtropical regions. Treatments are available; however, patients complain of side effects. Different species of plants have been screened as a potential source of new drugs against leishmaniasis. In this study, we investigated the antileishmanial activity of cilantro essential oil, and its main components: (E)-2-undecenal, (E)-2-decenal, (E)-2-dodecenal, decanal, dodecanal and n-tetradecanal. Cilantro’s essential oil achieved 98% inhibition of Leishmani donovani promastigotes. The aliphatic aldehydes (E)-2-undecenal, (E)-2-decenal and (E)-2-dodecenal, are effective inhibitors of in vitro cultures of L. donovani promastigotes and axenic amastigotes. These cilantro compounds showed no toxicity against L. donovani in THP1 macrophages cultures.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov