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Title:   Author  item
                                            Liu, Ge

                                                         - *George*item
                                            XU, LINGYANG - University Of Marylanditem
                                            HUANG, KEVIN - Collaborator
  Submitted to: Gene Expression
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 4/24/2014
                                    Publication  Date: 5/25/2014
                                    Citation: Liu, G., Xu, L., Huang, K.S. 2014. Recent advances in studying of copy number variation and gene expression. Gene Expression. 7:1-5 DOI:10.4137/GGG.S14286.Interpretive Summary: Copy number cariations (CNV)are segments of DNA showing increased or decreased numbers of copies from one individual to another.These CNV can have a significant impact on gene expression. In this review, we summaize recently published results related to CNV
and discuss new insights brought by emerging new technologies of next generation sequencing and single cell sequencing. Farmers, Scientist, and policy planners who need to improve animal health and production based on genome-enable animal selection will benefit from this review.
                                Technical Abstract: Copy number variations (CNVs) are gains and losses of genomic sequence between two individuals of a species. CNV can have a significant impact on the expression of genes mapped within, nearby and far away from the CNV event itself. Earlier studies have revealed that CNV effects can be caused by affecting gene dosage, through position effect, altering downstream pathways and regulatory networks, or modifying the chromosome structure and position within the nucleus. We will first review recently published results based on high resolution CNV and transcriptome data. We will then discuss new insights brought by emerging new technologies of next generation sequencing and single cell sequencing.


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