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Title:   Author  item
                                            SCHMIDT, TY - University Of Nebraskaitem
                                            BUNTYN, JOE - University Of Nebraskaitem
                                            Sanchez, Nicoleitem
                                            CHAVAUX, ERIC - Lallemand Animal Nutritionitem
                                            BARLING, KERRY - Lallemand Animal Nutritionitem
                                            SIEREN, SARA - University Of Nebraskaitem
                                            JONES, STEVEN - University Of Nebraskaitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 3/12/2014
                                    Publication  Date: 7/25/2014
                                    Citation: Schmidt, T.B., Buntyn, J.O., Sanchez, N.C., Chavaux, E., Barling, K., Sieren, S.E., Jones, S.J., Carroll, J.A. 2014. Supplementation of Saccharomyces cerevisiae modulates the metabolic response to lipopolysaccharide challenge in feedlot steers. Journal of Animal Science Supplement. 92(E-Suppl. 2):251 Abstract #504.Interpretive Summary:
                                Technical Abstract: Live yeast has the potential to serve as an alternative to the use of low-dose supplementation of antibiotics in cattle due to the ability to alter ruminant metabolism; which in turn may influence the immune response. Therefore, the objective of this study was to determine the metabolic response to a lipopolysaccharide (LPS) challenge in feedlot steers supplemented with Saccharomyces cerevisiae CNCM I-1079 (SC).  Steers (n=18; 266±4 kilograms body weight) were processed and separated into three treatment groups (n = 6/treatment): 1) steers were fed a standard receiving diet and served as the control (Cont); 2) steers were fed the receiving diet supplemented with SC (Lallemand, Inc.) at 0.5 grams/head/day (SC-0.5); and 3) steers were fed the control diet supplemented with SC at 5.0 grams/head/day (SC-5.0) for 29 days.  On day 27 steers were fitted with indwelling jugular cannulas and rectal temperature (RT) probes, and were placed in individual stalls.  On day 28, steers were challenged intravenously with LPS (0.5 micrograms/kilogram body weight at 0 hour) and blood samples were collected at 30-minute intervals from -2 to 8 hours and at 24 hours post-challenge. Serum was isolated and stored at -80C until analyzed for glucose, non-esterified fatty acids (NEFA), and blood urea nitrogen (BUN) concentrations. There was a treatment (P=0.02) and time effect (P<0.001) for glucose; SC-0.5 steers had greater glucose concentrations (77.8±1.6 milograms/deciliter) than Cont (71.5±1.3 milograms/deciliter) and SC-5.0 steers (71.6±1.4 milograms/deciliter). Glucose concentrations also increased (P<0.001) over time in response to LPS challenge. Concentrations of NEFA were also affected by time (P<0.001) but were not affected by treatment (P=0.42). For all treatments, NEFA concentrations increased in response to LPS challenge. There was a treatment (P<0.001) and a time (P<0.001) effect for BUN concentrations; BUN concentrations were greater (P<0.001) in SC-0.5 steers (14.5±0.2 milograms/deciliter) than Cont (12.8±0.2 milograms/deciliter) and SC-5.0 (12.8±0.2 milograms/deciliter) steers. For all three groups, BUN concentrations increased (P<0.001) in response to LPS challenge. These data demonstrate that Saccharomyces cerevisiae supplementation may alter the metabolic response to LPS challenge. Repartitioning of nutrients may help explain the variations in the acute phase response observed in cattle supplemented with Saccharomyces cerevisiae. Data from this study suggest that Saccharomyces cerevisiae products may be useful as alternatives to antibiotic use in feed in order to enhance cattle health.


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