U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Food and Feed Safety Research: College Station, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area College Station, Texas Southern Plains Agricultural Research Center Food and Feed Safety Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            PRADEEP, SELVANESAN - University Of Calicutitem
                                            SARATH, MOOLAKKARIYIL - University Of Calicutitem
                                            BALACHANDRAN, SREEDHARAN - Mahatma Gandhi Collegeitem
                                            SUDHADEVI, RUKMINI - Mahatma Gandhi Collegeitem
                                            SADASIVAM, RAMASAMY - Toshvin Analytical P Ltditem
                                            THIRUGHANA, PERUMAL - Quest Life Science Pvt Ltditem
                                            DOBLE, MUKESH - Indian Institute Of Technology Madrasitem
                                            Anderson, Robinitem
                                            BENJAMIN, SAILAS - University Of Calicut
  Submitted to: Bioresource Technology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 8/14/2014
                                    Publication  Date: 8/23/2014
                                    Publication URL: http://handle.nal.usda.gov/10113/61144Citation: Pradeep, S., Sarath, M.K., Balachandran, S., Sudhadevi, R., Sadasivam, R., Thirughana, P.E., Doble, M., Anderson, R.C., Benjamin, S. 2014. Achromobactor denitrificans SP1 produces pharmaceutically active 25C prodigiosin upon utilizing hazardous di(2-ethylhexyl)phthalate. Bioresource Technology. 171:482-486.Interpretive Summary: The chemical di(2-ethylhexyl)phthalate, or abbreviated to be referred to as DEHP, is a hazardous plasticizer and proven environmental contaminant known to cause various adverse health in humans such as cancer of the liver, toxicity to reproductive organs, and birth defects.  DEHP is used abundantly in the production of almost all polyvinylchloride (PVC) plastics, especially those produced for medical use.  In the present study, we demonstrate that a novel bacterium recently isolated from soil sludge heavily contaminated with plastic waste can efficiently degrade and transform DEHP wastes from the synthesis of commercial PVC plastic into a novel chemical exhibiting pharmaceutically several attractive properties including anti-bacterial, anti-fungal, and anti-parasitic activity.  Results from this research may ultimately provide new environmental friendly technology to remediate PVC plastic waste products into new beneficial compounds that may potentially be used to the reduce carriage of foodborne pathogens and to treat bacterial infections in food-producing animals.
                                Technical Abstract: Achromobacter denitrificans SP1 isolated from soil sludge heavily contaminated with plastic waste produced a novel pharmaceutically-active 25C prodigiosin analog during growth in a simple mineral salt medium supplemented with hazardous di(2-ethylhexyl)phthalate (DEHP) blended PVC plastics (in situ) or free DEHP (ex situ).  In silico studies indicated that A. denitificans SP1 exhibits moderate binding efficiency to the crucial molecular targets such as cycloxygenase-2, ZAP-70 and Jak-3 kinases.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov