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Title:   Author  item
                                            BUNTYN, JOE - University Of Nebraskaitem
                                            Sanchez, Nicoleitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            CHEVAUX, ERIC - Lallemand Animal Nutritionitem
                                            BARLING, KERRY - Lallemand Animal Nutritionitem
                                            SIEREN, SARA - University Of Nebraskaitem
                                            JONES, STEVEN - University Of Nebraskaitem
                                            SCHMIDT, TY - University Of Nebraska
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/10/2014
                                    Publication  Date: 7/25/2014
                                    Citation: Buntyn, J.O., Sanchez, N.C., Carroll, J.A., Chevaux, E., Barling, K., Sieren, S.E., Jones, S.J., Schmidt, T.B. 2014. Modulation of the acute phase response in feedlot steers supplemented with Saccharomyces cerevisiae. Journal of Animal Science Supplement. 92(E-Suppl. 2):43-44. Abstract #86.Interpretive Summary:
                                Technical Abstract: This study was designed to determine the effect of supplementing feedlot steers with Saccharomyces cerevisiae CNCM I-1079 (SC) on the acute phase response to a lipopolysaccharide (LPS) challenge.  Steers (n = 18; 266 ± 4 kilograms body weight) were separated into three treatment groups (n = 6/treatment): one group was fed a standard receiving diet (Control, Cont); one group was fed the standard receiving diet supplemented with SC (Lallemand, Inc.) at 0.5 grams/head/day (SC-0.5), and the final group was fed the standard receiving diet supplemented with SC at 5.0 grams/head/day (SC-5.0) for 29 days. On day 27 steers were fitted with indwelling jugular cannulas and rectal temperature (RT) probes that measured RT continuously at 5-minute intervals and were placed in individual stalls.  On day 28, steers were challenged intravenously with LPS (0.5 micrograms/kilogram body weight at 0 hour) and blood samples were collected at 30-minute intervals from -2 to 8 hours and 24 hours post-challenge.  Serum was isolated and stored at -80C until analyzed for cortisol and cytokine concentrations. Prior to the challenge there was an effect of treatment (P < 0.001) on RT; SC-0.5 steers (39.50± 0.03C) had greater RT than Cont (39.06 ± 0.04C) and SC-5.0 (39.27 ± 0.04C) steers. Also, Cont steers had greater (P < 0.001) RT than SC-5.0 steers. Therefore, RT was further analyzed as the change from baseline. In response to LPS challenge, the change in RT was affected by treatment (P < 0.001); Cont steers had the greatest change in RT (0.434 ± 0.0510C) compared to SC-0.5 (-0.059 ± 0.039C) and SC-5.0 (-0.007 ± 0.045C) steers. There was a tendency (P = 0.06) for baseline cortisol concentrations to be affected by treatment; SC-5.0 steers having greater (7.8 ± 0.8 ng/mL) cortisol than Cont (4.9 ± 0.8 ng/mL) steers. Post-LPS challenge, there was a treatment x time interaction (P = 0.005); SC-5.0 steers had decreased (P < 0.02) cortisol concentrations than Cont steers from 4.5 to 7 hours post-challenge. There was a treatment effect (P = 0.05) for all cytokines (tumor necrosis factor-alpha, interleukin-6, and interferon-gamma). Cytokines were decreased in SC-0.5 and SC-5.0 steers compared to Cont steers following LPS challenge. These data demonstrate that Saccharomyces cerevisiae supplementation can reduce the inflammatory response to a LPS challenge, and may be a beneficial supplement to reduce the negative effects of illness on cattle health.


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