U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Animal Biosciences & Biotechnology Laboratory: Beltsville, MD
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Announcements
                        ABBL Journal Club
                    USDA Civil Rights Policy StatementSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Animal Biosciences & Biotechnology Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            BAN, JI HYE - Chung-Ang Universityitem
                                            HONG, YEONG HO - Chung-Ang Universityitem
                                            DINH, HUE - Chung-Ang Universityitem
                                            TRUONG, ANH DUC - Chung-Ang Universityitem
                                            PARK, BO YEONG - Chung-Ang Universityitem
                                            Lillehoj, Hyun
  Submitted to: Poultry Science
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 2/8/2014
                                    Publication  Date: 6/20/2014
                                    Citation: Ban, J., Hong, Y., Dinh, H., Truong, A., Park, B., Lillehoj, H.S. 2014. Modulation of microrna in two genetically disparate chicken lines showing different necrotic enteritis disease susceptibility. Poultry Science. 93(6):1383-1395.Interpretive Summary:
                                Technical Abstract: Necrotic enteritis (NE) is a  re-emerging disease as a result of an increased restriction on the use of antibiotics in poultry.  However, the molecular mechanisms underlying the pathology of NE are unclear.  Therefore, we carried out small RNA transcriptome analysis in an experimentally induced NE model to investigate whether microRNAs (miRNA) may control the expression of genes associated with pathogenic challenge.  We also developed expression profiles of the small RNA transcriptome, including known or novel miRNAs, using Marek’s disease (MD) resistant and MD-susceptible chicken lines.  Next Generation Sequencing yielded ~40 million reads from each library.  The data indicated that unique miRNAs represented only 0.02-0.04% of the total number of sequences, and these mapped to 544 known chicken miRNAs.  Several of miRNAs which are identified in this study associated with target genes responding to NE and these include SOCS3- miR30b/c, CALB1- miR130b and CXCL14- miR101.  Although, those results should be confirmed by further experiments, it should be useful for understanding pathogen host interaction as well as providing insight into markers of disease resistance.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov