U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Loving, Crystalitem
                                            Brockmeier, Susanitem
                                            Baker, Amy
  Submitted to: International Pig Veterinary Society (IPVS)
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 3/30/2010
                                    Publication  Date: 7/18/2010
                                    Citation: Loving, C.L., Brockmeier, S., Vincent, A.L. 2010. Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, 2010, Vancouver, Canada. p. 264.Interpretive Summary:
                                Technical Abstract: Swine Influenza virus (SIV) infection and associated complications are a leading cause of morbidity and mortality.  It is appreciated that SIV is often complicated by secondary bacterial infection.  Tracheal epithelial cells (TEC) and pulmonary cells respond to infection with proinflammatory cytokines for controlling pathogen spread; however, exacerbated responses can lead to immunopathology that may be detrimental to the host.  The extent to which prior SIV infection alters host responses to secondary stimulation is poorly understood.  Haemophilus parasuis is an important and common respiratory pathogen of pigs.  The innate immune responses of the respiratory tract of pigs infected with SIV 5 days prior to secondary infection with H. parasuis were examined.  The H. parasuis colonization was higher in the nose and lungs of SIV/Hps pigs compared to Hps-only pigs.  These results indicate that influenza virus infection contributes enhanced bacterial colonization.  In SIV/Hps pigs, IL-8, IL-6 and IL-1beta protein levels were increased in the tracheal wash and BAL, and TEC and BAL cells IL-8, IL-6 and IL-1beta mRNA expression levels were significantly increased over SIV-only and Hps-only pigs. This data provides support to the hypothesis that prior influenza infection alters subsequent immune responses.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov