U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Livestock Issues Research: Lubbock, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    NewsletterSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Lubbock, Texas Cropping Systems Research Laboratory Livestock Issues Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            Sanchez, Nicoleitem
                                            WELSH JR, THOMAS - Texas A&M Universityitem
                                            RANDEL, RONALD - Texas A&M University
  Submitted to: Meeting Proceedings
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 4/12/2011
                                    Publication  Date: 5/4/2011
                                    Citation: Carroll, J.A., Sanchez, N.C., Welsh Jr, T.H., Randel, R.D. 2011. Variations in stress and immune responses of cattle: Natural deviations and nutritional influences. Proceedings of the California Animal Nutrition Conference, May 4, 2011, Fresno, California. p. 7-19.Interpretive Summary: A series of collaborative studies was conducted involving scientists from the Livestock Issues Research Unit, Texas AgriLife Research and Extension Center-Overton, and Texas AgriLife Research-College Station to elucidate the relationships between stress and immunity in cattle, and how these biological processes are influenced by factors such as animal temperament, sex, and nutritional supplements. Utilzing our bovine endotoxemia model generated by administering an E. coli-derived lipopolysaccharide (LPS) to cattle, we have discerned individual variations in the stress and innate immune responses in different breeds of Bos taurus cattle that are considered to be either heat-tolerant or heat-sensitive. We have also demonstrated natural variations in the stress and innate immune responses of Bos indicus cattle, revealing sexually dimorphic variations following exposure to LPS, as well as variations associated with animal temperament. Additionally, we have utilized this model to demonstrate that nutritional supplements can be an effective management tool for altering the innate immune response following exposure to LPS. Understanding the relationships that exist between stress and immune responses, and elucidating potential variations associated with various environmental conditions, the genetic makeup of the animal, and the impact of nutrition are essential steps toward developing new management strategies that will improve the overall health, productivity, and well-being of livestock. Therefore, this information will be of interest to both scientists and producers working in the area of beef cattle production with specific focus on the regulation of stress and immune responses.
                                Technical Abstract: Given the importance of the innate immune response with regard to the overall health and survival of domestic livestock, the primary immunological focus of this manuscript is on variations that exist within the innate immune system, and efforts to selectively and precisely modulate this system in a manner that is beneficial not only for survival, but also for enhancing productivity in domestic livestock. For more than a decade, our laboratory has utilized a reliable endotoxemia model generated by administering an E. coli-derived lipopolysaccharide (LPS) to livestock as a means to discern individual variations that exist in the innate immune response that can have s significant impact on the overall health and productivity of an animal. Utilizing this model, we have characterized variations in the stress and innate immune responses following exposure to LPS in different breeds of Bos taurus cattle that are considered to be either heat-tolerant or heat-sensitive. We have also demonstrated natural variations in the stress and innate immune responses of Bos indicus cattle, revealing sexually dimorphic variations following exposure to LPS, as well as variations associated with animal temperament. Additionally, we have utilized this model to demonstrate that nutritional supplements can be an effective management tool for altering the innate immune response following exposure to LPS. Therefore, we have narrowed the focus of this manuscript to research data specifically associated with experiments demonstrating genetic and nutritional influences on the innate immune response in cattle.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov