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Title:   Author  item
                                            Lee, Sungitem
                                            Lillehoj, Hyunitem
                                            JANG, SEUNG - US Department Of Agriculture (USDA)item
                                            LILLEHOJ, ERIK - University Of Marylanditem
                                            MIN, WONGI - Gyeongsang National Universityitem
                                            BRAVO, DAVID - Pancosma Sa
  Submitted to: American Association of Avian Pathologists
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/14/2014
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: The Clostridium-related poultry disease, necrotic enteritis (NE), causes substantial economic losses on a global scale.  In this study, a mixture of two plant-derived phytonutrients, Capsicum oleoresin and turmeric oleoresin (XT), was evaluated for its effects on local and systemic immune responses using a co-infection model of experimental NE in commercial broilers.  Chickens were fed from hatch with a diet supplemented with XT, or with a non-supplemented control diet, and either uninfected or orally challenged with virulent Eimeria maxima oocyts at 14 d and Clostridium perfringens at 18 d of age.  Parameters of protective immunity were 1) body weight, 2) gut lesions, 3) serum levels of C. perfringens a-toxin and NetB toxin, 4) serum levels of antibodies to a-toxin and NetB toxin, and 5) levels of gene transcripts encoding proinflammatory cytokines and chemokines in the intestine and spleen.  Infected chickens fed the XT-supplemented diet had increased body weight and reduced gut lesion scores compared with infected birds given the non-supplemented diet.  The XT-fed group also displayed decreased serum a-toxin levels and reduced intestinal IL-8, LITAF, IL-17A, and IL-17F mRNA levels, while cytokine/chemokine levels in splenocytes increased in the XT-fed group, compared with animals fed the control diet.  In conclusion, this study documents the molecular and cellular immune changes following dietary supplementation with extracts of Capsicum and turmeric that may be relevant to protective immunity against avian NE.


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