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- Rebecca Milczarek *(Scopus)*
- Yuzhu Zhang *(PubMed)*

Title:   Author  item
                                            KIM, HYUNSOOK - University Of Californiaitem
                                            WANG, QIAN - Jiangnan Universityitem
                                            SHOEMAKER, CHARLES - University Of Californiaitem
                                            ZHONG, FANG - Jiangnan Universityitem
                                            Bartley, Glennitem
                                            Yokoyama, Wallace

                                                         - *Wally*
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 3/28/2013
                                    Publication  Date: 5/30/2013
                                    Citation: Kim, H., Wang, Q., Shoemaker, C.F., Zhong, F., Bartley, G.E., Yokoyama, W.H. 2013. Gel coating of edible Brasenia schreberi leaves lowers plasma cholesterol in hamsters (abstract). 10th International Conference of Food Science and Technology, Wuxi, China, May 29-31, 2013.Interpretive Summary:
                                Technical Abstract: The young leaves of B. schreberi are coated with gelatinous water-insoluble mucilage.  This mucilage is a polysaccharide composed of galactose, mannose, fucose and other monosaccharides.  Since some carbohydrate gels are hypocholesterolemic, we evaluated the cholesterol lowering properties in male hamsters fed hypercholesterolemic diets containing either 2% gel coat from B. schreberi (GEL), or 1% cholestyramine (CA), or 5% hydroxypropyl methylcellulose (HPMC) and compared them to 5% microcrystalline cellulose (control) for 3 weeks. We found that plasma VLDL-, LDL-, and total-cholesterol concentrations were significantly lowered by GEL, CA, and HPMC compared to control.  HDL-cholesterol concentration was lowered by CA and HPMC.  Body weights were not changed by any treatment but abdominal adipose tissue weight from GEL fed animals was greater compared to the control group.  Fecal lipid excretion was greater in the CA and HPMC than the control.  Expression of hepatic CYP51 and CYP7A1 mRNA was up-regulated by CA, HPMC and GEL, indicating increased hepatic cholesterol and bile acid synthesis. Expression of LDLR mRNA was up-regulated by all treatments. These results suggest that modulation of hepatic expression of cholesterol and bile acid metabolism-regulated genes contributes to the cholesterol-lowering effects of GEL.


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