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ARS Home Plains Area Lubbock, Texas Cropping Systems Research Laboratory Livestock Issues Research Research Publications at this Location





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Title:   Author  item
                                            SCHMIDT, SARAH - Texas A&M Universityitem
                                            ROBERTS, MEGHAN - Texas A&M Universityitem
                                            PRICE, DEBORAH - Texas A&M Universityitem
                                            LITTLEJOHN, BRITTANI - Texas A&M Universityitem
                                            VANN, RHONDA - Mississippi State Universityitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            Sanchez, Nicoleitem
                                            NEUENDORFF, DON - Texas A&M Universityitem
                                            LEWIS, ANDREW - Texas A&M Universityitem
                                            WELSH, JR., THOMAS - Texas A&M Universityitem
                                            RANDEL, RONALD - Texas A&M Agrilife
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 11/27/2013
                                    Publication  Date: 7/25/2014
                                    Citation: Schmidt, S.M., Roberts, M.C., Price, D.P., Littlejohn, B.P., Vann, R.C., Carroll, J.A., Sanchez, N.C., Neuendorff, D.A., Lewis, A.W., Welsh, Jr., T.H., Randel, R.D. 2014. Prenatal stress influences the insulin response to a glucose challenge in yearling Brahman heifers. Journal of Animal Science Supplement. 92(E-Suppl. 1):12-13. (Abstract #32).Interpretive Summary:
                                Technical Abstract: The effect of prenatal stress on postnatal glucose metabolism was studied in progeny of cows that did or did not experience a transportation event during gestation. Specifically, 12 prenatally stressed (dams transported for 2 hours on days 40, 60, 80, 120, and 140 of gestation) and 12 Control yearling heifers of similar body weight (211+/-4.4 kilograms) were balanced for temperament and subjected to an intravenous glucose tolerance test to compare insulin responsiveness and glucose clearance. The heifers were fitted with jugular vein cannulas and placed in individual stanchions. Following a 2-hour acclimation period, a 50% dextrose solution was administered to each heifer (0.5 mililiters/kilogram body weight). Blood samples were collected during the acclimation period, immediately prior to, and following the glucose challenge at intervals of 10 and 20 minutes. Serum concentrations of glucose and insulin were determined by enzymatic assay and enzyme-linked immunosorbant assay, respectively. Repeated measures mixed models analyses were used to compare glucose and insulin
concentrations and the ratio of insulin to glucose (IGR) over time. Prenatal treatment significantly affected concentrations of insulin (P=0.03), but not glucose concentrations (P=0.61), over time. Prenatal treatment also affected the IGR over time (P=0.01). Table 1 lists basal glucose and insulin concentrations, peak insulin concentration, the insulinogenic index (delta I/delta G) at 30 minute post-challenge, the time to peak insulin concentration, and the time to reach basal insulin and glucose concentrations. Prenatally stressed heifers were less insulin resistant than Control heifers. Prenatally stressed heifers
had decreased insulin concentrations (P=0.03) and returned to basal glucose and insulin concentrations earlier following the glucose challenge (P<0.01). These data suggest that prenatal stress enhances insulin sensitivity in Brahman calves.


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