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 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





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Title:   Author  item
                                            IQBAL, JAMEEL - University Of Pennsylvaniaitem
                                            SUN, LI - University Of Pennsylvaniaitem
                                            Cao, Jayitem
                                            YUEN, TONY - Mount Sinai School Of Medicineitem
                                            BAB, ITAI - Hebrew Universityitem
                                            LEU, NICOLAE - University Of Pennsylvaniaitem
                                            WAGAGE, SAGIE - University Of Pennsylvaniaitem
                                            HUNTER, CHRISTOPHER - University Of Pennsylvaniaitem
                                            NEBERT, DANIEL - University Of Cincinnatiitem
                                            ZAIDI, MONE - Mount Sinai School Of Medicine
  Submitted to: Proceedings of the National Academy of Sciences (PNAS)
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 5/21/2013
                                    Publication  Date: 7/2/2013
                                    Publication URL: http://handle.nal.usda.gov/10113/58061Citation: Iqbal, J., Sun, L., Cao, J.J., Yuen, T., Bab, I., Leu, N., Wagage, S., Hunter, C., Nebert, D.W., Zaidi, M. 2013. Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of CYP1 enzymes. Proceedings of the National Academy of Sciences. 110(27):1115-11120.Interpretive Summary: Smoking is one of the risk factors for osteoporosis and fracture. Cigarettes contain at least 150 known toxic molecules, such as benzo[a]pyrene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and 3-methyl cholanthrene. Here, we present genetic and pharmacological evidence that these smoke toxins stimulate osteoclastogenesis, suggesting smoke carcinogens promote bone resorption.
                                Technical Abstract: Smoking is a major risk factor for osteoporosis and fracture. Here, we show that smoke toxins and environmental chemicals such as benzo[a]pyrene (BaP), 2,3,7,8-tetrachlorodibenzo-pdioxin
(TCDD), and 3-methyl cholanthrene, which are well known aryl hydrocarbon receptor (AHR) agonists, induce osteoclast formation, although the precise mechanisms remain constroversial. We therefore investigated the ex vivo as well as in vivo effects of BaP and TCDD on primary bone marrow cells and mouse models of AHR and AHR regulated CYP1 (CYP1A1, CYP1A2 and CYP1B1) knockout mice.


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