U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            RAJÃO, DANIELA - Non ARS Employeeitem
                                            Loving, Crystalitem
                                            GAUGER, PHILLIP - Iowa State Universityitem
                                            Kitikoon, Pravinaitem
                                            Baker, Amy
  Submitted to: American Society for Virology Meeting
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/14/2014
                                    Publication  Date: 6/21/2014
                                    Citation: Rajão, D.S., Loving, C.L., Gauger, P.C., Kitikoon, P., Vincent, A.L. 2014. Immune response to influenza A virus hemagglutinin protein is sufficient to induce vaccine-associated enhanced respiratory disease. American Society for Virology  33rd Annual Meeting. p. 199.Interpretive Summary:
                                Technical Abstract: The antigenic diversity of influenza A virus (IAV) circulating in pigs continues to complicate control of swine influenza through the use of vaccination in the United States. The antibody response elicited by whole inactivated virus (WIV) vaccines can lead to vaccine-associated enhanced respiratory disease (VAERD) when pigs are challenged with heterologous virus. The aim of this study was to compare the effects of heterologous delta1-H1N2 IAV challenge after vaccination of pigs with 2009 pandemic H1N1 virus (H1N1pdm09) recombinant hemagglutinin (HA) subunit vaccine (HA-SV) or temperature-sensitive live attenuated influenza virus (LAIV) vaccine, and to assess the role of immunity to HA in the development of VAERD. Both HA-SV and LAIV vaccines induced high neutralizing antibodies to virus with homologous HA (H1N1pdm09), but not to the heterologous challenge virus (delta1-H1N2). No virus was detected in the lungs of LAIV vaccinated pigs by 5 days post infection (dpi) and pigs in this group had reduced virus titers in nasal secretions, indicating partial protection. HA-SV vaccinated pigs developed more severe lung and tracheal lesions following challenge, consistent with VAERD, however at an intermediate level than previously observed with WIV vaccination. These results demonstrate that immunity to IAV HA protein alone was sufficient to initiate the mechanisms involved with VAERD following heterologous challenge, but immune response to other viral proteins may be involved in the magnitude of the immunopathology seen with WIV.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov