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Title:   Author  item
                                            LUO, JUAN - University Of Marylanditem
                                            YU, YING - China Agricultural Universityitem
                                            MITRA, APRATIM - University Of Marylanditem
                                            Zhang, Huanminitem
                                            Liu, Ge

                                                         - *George*item
                                            SONG, JIUZHOU - University Of Maryland
  Submitted to: Plant and Animal Genome Conference
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 11/30/2012
                                    Publication  Date: 1/14/2013
                                    Citation: Luo, J., Yu, Y., Mitra, A., Zhang, H., Liu, G., Song, J. 2013. Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0649. Avaliable: https://pag.confex.com/pag/xxi/webprogram/Paper5185.html.Interpretive Summary:
                                Technical Abstract: Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was initially examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNV regions (CNVR) were found in 4 lines of chickens, and 28 of them were potentially involved in immune response and cell proliferation. More importantly, two CNVRs related with MD-resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may help to make a better strategy for MD resistance in poultry.


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