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ARS Home Northeast Area Beltsville, Maryland (BARC) Beltsville Agricultural Research Center Bee Research Laboratory Research Publications at this Location





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Title:   Author  item
                                            Chen, Yanping

                                                         - *Judy*item
                                            Pettis, Jefferyitem
                                            Corona, Miguelitem
                                            CHEN, WEI PING - National Institutes Of Health (NIH)item
                                            SPIVAK, MARLA - University Of Minnesotaitem
                                            VISSCHER, KIRK - University Of Californiaitem
                                            DeGrandi-Hoffman, Gloriaitem
                                            BONCRISTIANI, HUMBERTO - University Of North Carolinaitem
                                            Zhao, Yanitem
                                            VANENGELSDORP, DENNIS - University Of Marylanditem
                                            DELAPLANE, KEITH - University Of Georgiaitem
                                            SOLTER, LEELLEN - University Of Illinoisitem
                                            DRUMMOND, FRANCIS - University Of Maineitem
                                            Kramer, Matthewitem
                                            LIPKIN, IAN - Columbia University - New Yorkitem
                                            PALACIOS, GUSTAVO - George Mason Universityitem
                                            Hamilton, Micheleitem
                                            Smith Jr, Irvingitem
                                            HUANG, SHAOKANG - Fujian Agricultural & Forestry Universityitem
                                            ZHENG, HUO QING - Zhejiang Universityitem
                                            LI, JI LIAN - Chinese Academy Of Agricultural Sciencesitem
                                            ZHANG, XUAN - Yunnan Agricultural Universityitem
                                            ZHOU, AI FEN - University Of Oklahomaitem
                                            WU, LI YOU - University Of Oklahomaitem
                                            ZHOU, JI ZHONG - University Of Oklahomaitem
                                            LEE, MYEONG - National Academy Of Agricultural Scienceitem
                                            TEIXEIRA, ERICA - Agencia Paulista De Tecnologia Dos Agronegocios/saa-Spitem
                                            LI, ZHI GUO - Zhejiang Universityitem
                                            Evans, Jayitem
                                            Li, Congjun

                                                         - *Cj*
  Submitted to: PLoS Pathogens
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 6/6/2014
                                    Publication  Date: 7/31/2014
                                    Citation: Chen, Y., Pettis, J.S., Corona, M.V., Chen, W., Spivak, M., Visscher, K.P., Hoffman, G.D., Boncristiani, H., Zhao, Y., Vanengelsdorp, D., Delaplane, K., Solter, L., Drummond, F., Kramer, M.H., Lipkin, I.W., Palacios, G., Hamilton, M.C., Smith Jr, I.B., Huang, S., Zheng, H., Li, J., Zhang, X., Zhou, A., Wu, L., Zhou, J., Lee, M.L., Teixeira, E.W., Li, Z., Evans, J.D., Li, C. 2014. Israeli acute paralysis virus: epidemiology, pathogenesis and implications for honey bee health and Colony Collapse Disorder (CCD). PLoS Pathogens. 10 (7):e1004261. DOI: 10.1371/journal.ppat.1004261.Interpretive Summary: The mysterious outbreak of honey bee Colony Collapse Disorder (CCD) in the US in 2006-2007 has attracted massive media attention and created great concerns over the effects of various risk factors on bee health.  Understanding the factors that are linked to the massive honey bee die off may provide insights for managing similar incidents in the future.  We conducted a study to investigate the impacts of a pathogenic virus on honey bee colony losses and developed an innovative strategy to control the bee disease caused by the virus.  Our study provides clear evidence about the role of the virus in bee colony losses and emphasizes the importance of controlling parasitic mites Varroa in bee disease management.   The knowledge and insights gained from this study will have positive implications for bee disease management that will lead to mitigation of escalating colony losses worldwide.
                                Technical Abstract: Israeli acute paralysis virus (IAPV) is a widespread RNA virus that was linked with honey bee Colony Collapse Disorder (CCD), the sudden and massive die-off of honey bee colonies in the U.S.  in 2006-2007.  Here we describe the transmission, prevalence and genetic diversity of IAPV, host transcriptional responses to infections and  impacts of IAPV on colony losses.  Further, we present RNAi-based strategies for limiting an important mechanism used by IAPV to evade host defenses.  These strategies show promise for reducing IAPV impacts on bee health. Our study shows that IAPV is established as a persistent infection in the U.S. honey bee populations, enabled by both horizontal and vertical transmission pathways.  While IAPV is not the only culprit responsible for CCD and other colony losses, its ability to cause increased mortality in honey bees is firmly demonstrated.  The phenotypic differences in pathology among different strains of IAPV may be due to high levels of standing genetic variation.  The JAK-STAT pathway, along with other signaling events such as the mTOR and MAPK pathways, is implicated in antiviral responses by honey bees toward IAPV.  The identification of an IAPV-encoded putative suppressor of RNAi, and evidence that silencing this suppressor reduces IAPV replication, indicates a novel therapeutic strategy for limiting IAPV and colony losses due to viral diseases.


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