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Title:   Author  item
                                            Liu, Ge

                                                         - *George*item
                                            Brown, Twainitem
                                            Hebert, Deborah

                                                         - *Van Hook*item
                                            CARDONE, MARIA - University Of Bariitem
                                            HOU, YALI - University Of Marylanditem
                                            CHOUDHARY, RATAN - University Of Marylanditem
                                            Shaffer, Jessicaitem
                                            AMAZU, CHINWENDU - University Of Marylanditem
                                            Connor, Erinitem
                                            VENTURA, MARIO - University Of Bariitem
                                            Gasbarre, Louis
  Submitted to: Plant and Animal Genome Conference Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/1/2011
                                    Publication  Date: 1/15/2011
                                    Citation: Liu, G., Brown, T.E., Hebert, D.A., Cardone, M.F., Hou, Y., Choudhary, R.K., Shaffer, J.F., Amazu, C., Connor, E.E., Ventura, M., Gasbarre, L.C. 2011. Initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes. Plant and Animal Genome Conference Proceedings. Plant and Animal Genome Conference XIX Proceedings. P542.Interpretive Summary:
                                Technical Abstract: Genomic structural variation is an important and abundant source of genetic and phenotypic variation. We report an initial analysis of copy number variations (CNVs) in cattle selected for resistance or susceptibility to intestinal nematodes. We performed 3 array comparative genomic hybridization (CGH) experiments to compare Angus cattle with extreme phenotypes for fecal egg count and serum pepsinogen level. We identified 20 CNVs in total, of which 12 were within known chromosomes harboring or adjacent to gains or losses. About 85% of the CNV identified (17/20) overlapped with cattle CNV regions that were reported recently. Selected CNVs were further validated by independent methods using quantitative PCR (qPCR) and FISH. Pathway analyses indicated that annotated cattle genes within these variable regions are particularly enriched for immune function affecting receptor activities, signal transduction, and transcription. Analysis of TFBS within the promoter regions of differentially-expressed genes suggested that common transcription factors are probably involved in parasite resistance. These results provide valuable hypotheses for the future study of cattle CNVs underling economically-important health and production traits.


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