U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Loving, Crystal
  Submitted to: American Veterinary Medical Association Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/1/2013
                                    Publication  Date: 7/19/2013
                                    Citation: Loving, C.L. 2013. Biotherapeutics as alternatives to antibiotics. 2013 American Veterinary Medical Association (AVMA) Annual Convention, July 19-23, 2013, Chicago, Illinois. Paper No. 13906.Interpretive Summary:
                                Technical Abstract: Increasing pressure to limit antibiotic use in agriculture is heightening the need for alternative methods to reduce the adverse effects of clinical and subclinical disease on livestock performance that are currently managed by in-feed antibiotic usage. Immunomodulators have long been sought as such a method for therapeutic, prophylactic or metaphylactic approaches in livestock to prevent and combat infectious disease during periods of peak disease incidence. In humans, granulocyte colony stimulatory factor (G CSF) is used to reduce the risk of respiratory infections associated with compromised immunity in chemotherapy patients. G-CSF is a cytokine that controls the normal daily production, differentiation, and function of granulocytes from the bone marrow. Previous studies with G-CSF administration in cattle have shown significant enhancement of disease resistance against various bacterial pathogens including but not limited to Staphylococcus aureus, Escherichia coli and Klebsiellia pneumonia, as well as respiratory pathogens. However, a limitation of a biotherapeutic cytokine such as G-CSF, is the very short half-life resulting in a short duration of effectiveness thus limiting their practical use as a one-time injectable in production animal medicine. To address this issue, we developed a method to circumvent the need for production of a recombinant cytokine and the short half-life limitation by using a replication-defective adenovirus vector that expresses porcine G-CSF. Intramuscular administration of this vector expressing porcine G-CSF was found to effect a substantial persistent neutrophilia of at least 3 weeks duration. These findings provide evidence that it is possible to deliver G-CSF to have a sustained increase in circulating neutrophil numbers in pigs that may be a useful alternative to antibiotics for prophylactic or metaphylactic control of various bacterial pathogens associated with swine diseases. This presentation will summarize studies evaluating the effects of this type of biotherapeutic on respiratory and enteric pathogens in pigs.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov