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Title:   Author  item
                                            BUTLER, JOHN - University Of Iowaitem
                                            Lager, Kellyitem
                                            Golde, Williamitem
                                            Faaberg, Kayitem
                                            SINKORA, MAREK - Academy Of Science Of Czech Republicitem
                                            Loving, Crystalitem
                                            ZHANG, YANJIN - University Of Maryland
  Submitted to: Immunological Research
                                    Publication Type: Review Article
                                    Publication Acceptance Date: 6/1/2014
                                    Publication  Date: 8/1/2014
                                    Citation: Butler, J.E., Lager, K.M., Golde, W., Faaberg, K.S., Sinkora, M., Loving, C., Zhang, Y.I. 2014. Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research. 59(1-3):81-108.Interpretive Summary:
                                Technical Abstract: Porcine reproductive and respiratory disease syndrome (PRRS) is a viral pandemic that especially affects neonates within the "critical window" of immunological development. PRRS was recognized in 1987 and within a few years became pandemic causing an estimated yearly $600,000 economic loss in the USA with comparative losses in most other countries. The causative agent is a single-stranded, positive-sense enveloped arterivirus (PRRSV) that infects macrophages and pDCs.  Despite the discovery of PRRSV in 1991 and the publication of > 2000 articles, the control of PRRS is problematic. Despite the large volume of literature on this disease, the cellular and molecular mechanisms describing how PRRSV dysregulates the host immune system is poorly understood. We know that PRRSV suppresses innate immunity, causes abnormal B cell proliferation and repertoire development, often lymphopenia and thymic atrophy. The PRRSV genome is highly diverse, rapidly evolving but amenable to the generation of many mutants and chimeric viruses for experimental studies. PRRSV only replicates in swine which adds to the experimental difficulty since no inbred well-defined animal models are available. In this article we summarize current knowledge and apply it towards developing a series of provocative and testable hypotheses to explain how PRRSV immunomodulates the porcine immune system with the goal of adding new perspectives on this disease.


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