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Title:   Author  item
                                            Straus, David

                                                         - *Dave*
  Submitted to: Aquatic Animal Drug Approval Partnership (AADAP)
                                    Publication Type: Other
                                    Publication Acceptance Date: 8/1/2012
                                    Publication  Date: 8/31/2012
                                    Citation: Straus, D.L. 2012. USDA’s Corner [abstract]. Aquatic Animal Drug Approval Partnership (AADAP). 8(2):10-11.Interpretive Summary:
                                Technical Abstract: ARS Corner

Aquaculture America 2012
The Aquaculture Drug Research and Drug Approval Status special session had 12 presentations with great attendance for each presentation.  The session is organized and moderated by Jim Bowker and Dave Straus, and this was the 10th year we have held this session focused on research in aquaculture therapeutants.  We are soliciting speakers for Aquaculture 2013 in Nashville, so if you are interested in presenting, contact Jim or me.

Copper Sulfate (CuSO4)
Two Final Study Reports covering the pivotal effectiveness dose-confirmation study of CuSO4 on fungus of channel catfish eggs have been sent to the sponsor and should be submitted to the FDA by the time you read this.  This should complete all technical sections except for Environmental Safety.  

Also, we recently completed a study where we held catfish in water that was treated with CuSO4 for 24 h and then looked at fish resistance to columnaris after 0 h, 24 h and 9 d.  We challenged the fish in our low-flow aquarium system and found fish were significantly resistant at 24 h and 9 d, but not a 0 h.  This information is useful for transferring fingerlings to ponds or grading fish. 

Peracetic Acid (PAA)
Our work with peracetic acid (PAA) continues; we have completed studies on the effectiveness of PAA to control fungus on eggs and to determine the LC50 and resulting histopathology of catfish fry exposed to PAA.  We found that the optimum flow-through treatment rate for PAA was 5 mg/L to control egg fungus, but 2.5 mg/L gives a greater margin of safety to hatching fry. In the toxicity study, we found that yolk-sac fry were more tolerant of PAA than swim-up fry by 1.4-fold (24/48 h LC50 values were 2.6 vs. 1.8 mg/L PAA).  An advantage to using PAA includes very low environmental impact considerations, as it degrades to harmless residues rapidly.

Dave Straus, USDA/ARS, Harry K. Dupree – Stuttgart National Aquaculture Research Center, Stuttgart, AR.


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