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 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





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Title:   Author  item
                                            BALIRAM, RAMKUMARIE - Mount Sinai School Of Medicineitem
                                            SUN, LI - Mount Sinai School Of Medicineitem
                                            Cao, Jayitem
                                            LI, JIANHUA - Mount Sinai School Of Medicineitem
                                            LATIF, RAUF - Mount Sinai School Of Medicineitem
                                            HUBER, AMANDA - Mount Sinai School Of Medicineitem
                                            YUEN, TONY - Mount Sinai School Of Medicineitem
                                            BLAIR, HARRY - Mount Sinai School Of Medicineitem
                                            ZAIDI, MONE - University Of Pittsburghitem
                                            DAVIES, TERRY - Mount Sinai School Of Medicine
  Submitted to: Journal of Clinical Investigation
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/26/2012
                                    Publication  Date: 10/1/2012
                                    Publication URL: https://handle.nal.usda.gov/10113/56709Citation: Baliram, R., Sun, L., Cao, J.J., Li, J., Latif, R., Huber, A.K., Yuen, T., Blair, H.C., Zaidi, M., Davies, T.F. 2012. Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. Journal of Clinical Investigation. 122(10):3737-3741.Interpretive Summary: Hyperthyroidism is accompanied by worsening osteoporosis. Elevated thyroid hormone levels are a major contributor of the bone loss in hyperthyroidism. Serum thyroid hormone suppresses the production of thyroid stimulating hormone (TSH). TSH is low in hyperthyroid states and directly affects bone metabolism. Mice lacking the TSH receptor (TSHR) have significant bone loss. We show that TSHR-deficient mice have greater bone loss in hyperthyroid state than wild type controls. Our data suggest that TSH plays an important role in bone metabolism and suppression of TSH to very low levels may induce bone loss in humans.
                                Technical Abstract: The osteoporosis associated with human hyperthyroidism has traditionally been attributed to elevated thyroid hormone levels. There is evidence, however, that thyroid-stimulating hormone (TSH), which is low in most hyperthyroid states, directly affects the skeleton. Importantly, Tshr-knockout mice are osteopenic. In order to determine whether low TSH levels contribute to bone loss in hyperthyroidism, we compared the skeletal phenotypes of wild-type and Tshr-knockout mice that were rendered hyperthyroid. We found that hyperthyroid mice lacking TSHR had greater bone loss and resorption than hyperthyroid wild-type mice, thereby demonstrating that the absence of TSH signaling contributes to bone loss. Further, we identified a TSH-like factor that may confer osteoprotection. These studies suggest that therapeutic suppression of TSH to very low levels may contribute to bone loss in people.


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