U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Livestock Bio-Systems: Clay Center, NE
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    USMARC Home
                    USMARC Research Units
                        Genetics and Animal Breeding
                                    Meat Safety & Meat Quality
                                    Nutrition, Growth and Physiology
                                    Animal Health GenomicsSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Clay Center, Nebraska U.S. Meat Animal Research Center Livestock Bio-Systems Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- IACUC Summaries

Title:   Author  item
                                            Rohrer, Garyitem
                                            Rempel, Leaitem
                                            Miles, Jeremyitem
                                            Keele, Johnitem
                                            Vallet, Jeff
  Submitted to: Midwestern Section of the American Society of Animal Science
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/19/2012
                                    Publication  Date: 3/1/2013
                                    Citation: Rohrer, G.A., Rempel, L.A., Miles, J.R., Keele, J.W., Vallet, J.L. 2013. Identification of QTL affecting a piglet’s ability to acquire and absorb gamma-immunoglobulin from colostrum [abstract]. Journal of Animal Science. 91 (Supplement 2):63-64 (Abstract #O189).Interpretive Summary:
                                Technical Abstract: Consumption of an adequate amount of colostrum is critical to a piglet’s survival and productivity. The immunocrit is an inexpensive rapid measurement of the amount of gamma-immunoglobulin absorbed by a piglet. Genetic analysis of immunocrits on 5,312 piglets indicated that the heritabilities (se) for direct and maternal effects were 0.13(0.06) and 0.53(0.08), respectively. To identify QTL for direct genetic effects, piglets with the highest and lowest immunocrits from litters of eight or more were selected from 470 litters. The second highest and second lowest piglets in 24 litters were also selected. Pools were assigned based on sire of the litter. Six sets of high and low pools were created by mixing equal quantities of DNA of ~100 piglets. Pools 1 through 5 were unique and pool 6 contained a subsample of piglets from pools 1 and 2 from litters with the greatest variation. The 12 DNA pools were applied to SNP60 BeadChips. Normalized X and Y values were evaluated with three different methods and the 25 highest ranking SNP were selected from each evaluation for further study. In addition, 10 regions were studied based on a 5-SNP window approach. Selected SNP were individually genotyped in the 988 piglets included in pools as well as 524 piglets that had intermediate immunocrits. Association analyses were conducted fitting an animal model and using genetic parameters previously estimated. Twenty-five SNP were associated (P < 0.01) with immunocrit values and 10 remained significant (P < 0.05) after Bonferroni correction. These 25 markers were located in 18 genomic regions on 14 different chromosomes. In conclusion, the pooling strategy employed reduced the cost to scan the genome by more than 80% and identified genetic markers that can be used to improve a piglet’s ability to acquire gamma-immunoglobulin from colostrum.
USDA is an equal opportunity provider and employer.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov