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Title:   Author  item
                                            PSYCHOGIOS, NIKOLAOS - University Of Albertaitem
                                            HAU, DAVID - University Of Albertaitem
                                            PENG, JUN - University Of Albertaitem
                                            GUO, AN CHI - University Of Albertaitem
                                            MANDAL, RUPARSI - University Of Albertaitem
                                            BOUATRA, SOUHAILA - University Of Albertaitem
                                            SINELNIKOV, IGOR - University Of Albertaitem
                                            KRISHNAMURTHY, RAMANARAYAN - University Of Albertaitem
                                            EISNER, ROMAN - University Of Albertaitem
                                            GAUTAM, BIJAYA - University Of Albertaitem
                                            YOUNG, NELSON - University Of Albertaitem
                                            XIA, JINAGUO - University Of Albertaitem
                                            KNOX, CRAIG - University Of Albertaitem
                                            DONG, EDISON - University Of Albertaitem
                                            HUANG, PAUL - University Of Albertaitem
                                            HOLLANDER, ZSUZSANNA - University Of British Columbiaitem
                                            Pedersen, Theresaitem
                                            SMITH, STEVEN - Pennington Biomedical Research Centeritem
                                            BAMFORTH, FIONA - University Of Albertaitem
                                            GREINER, RUSS - University Of Albertaitem
                                            MCMANUS, BRUCE - University Of British Columbiaitem
                                            Newman, Johnitem
                                            GOODFRIEND, THEODORE - University Of Wisconsinitem
                                            WISHART, DAVID - University Of Alberta
  Submitted to: PLOS ONE
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/18/2011
                                    Publication  Date: 2/16/2011
                                    Citation: Psychogios, N., Hau, D.D., Peng, J., Guo, A., Mandal, R., Bouatra, S., Sinelnikov, I., Krishnamurthy, R., Eisner, R., Gautam, B., Young, N., Xia, J., Knox, C., Dong, E., Huang, P., Hollander, Z., Pedersen, T.L., Smith, S.R., Bamforth, F., Greiner, R., Mcmanus, B., Newman, J.W., Goodfriend, T., Wishart, D.S. 2011. THE HUMAN SERUM METABOLOME. PLoS One. 6(2): e16957.Interpretive Summary: Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today‘s technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.
                                Technical Abstract: Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today‘s technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca.


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