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Title:   Author  item
                                            Duke, Stephenitem
                                            Baerson, Scottitem
                                            Cantrell, Charlesitem
                                            Wedge, Daviditem
                                            Meepagala, Kumudiniitem
                                            Pan, Zhiqiang

                                                         - *Peter*item
                                            Rimando, Agnesitem
                                            Schrader, Kevinitem
                                            TABANCA, NURHAYAT - University Of Mississippiitem
                                            Owens, Danielitem
                                            Dayan, Franck
  Submitted to: Recent Advances in Phytochemistry
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 7/30/2012
                                    Publication  Date: 11/1/2013
                                    Citation: Duke, S.O., Baerson, S.R., Cantrell, C.L., Wedge, D.E., Meepagala, K.M., Pan, Z., Rimando, A.M., Schrader, K., Tabanca, N., Owens, D.K., Dayan, F.E. 2013. Phytochemicals for pest management: current advances and future opportunities. Recent Advances in Phytochemistry. 43:71-94.Interpretive Summary: This review provides examples of natural product-based pesticides that are now commercial successes, as well as a few examples of the many natural compounds that we have studied which are active against pests.  Our group’s research is but a small sampling of the extensive, international effort to discover natural product-based pest management products.  Some have argued that we have reached diminishing returns with this approach, but an analysis of the number of new phytochemicals being discovered yearly and the relatively few bioassays for potential pesticidal activity that most of the known phytochemicals have been subjected to, indicates that this is not the case.  Furthermore, chemical modification of these compounds and use of them to discover new modes of action greatly expands the work yet to be done. We also provide an example from our lab (sorgoleone in sorghum) of genetically engineering the production of a plant protection phytochemical in plants.
                                Technical Abstract: This review provides examples of natural product-based pesticides that are now commercial successes, as well as a few examples of the many natural compounds that we have studied which are active against pests.  Our group’s research is but a small sampling of the extensive, international effort to discover natural product-based pest management products.  Some have argued that we have reached diminishing returns with this approach, but an analysis of the number of new phytochemicals being discovered yearly and the relatively few bioassays for potential pesticidal activity that most of the known phytochemicals have been subjected to, indicates that this is not the case.  Furthermore, chemical modification of these compounds and use of them to discover new modes of action greatly expands the work yet to be done. We also provide an example from our lab (sorgoleone in sorghum) of genetically engineering the production of a plant protection phytochemical in plants.


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