U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Exotic & Emerging Avian Viral Diseases Research: Athens, GA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    USNPRC
                        Richard B Russell Center
                                    Southeast Poultry Research Center
                                    Return to USNPRC home page
                    Research Units at USNPRC
                        Quality and Safety Assessment Research
                                    Poultry Microbiological Safety and Processing Research
                                    Toxicology and Mycotoxin Research
                                    Egg and Poultry Production Safety Research Unit
                                    Exotic and Emerging Avian Viral Diseases
                                    Endemic Poultry Viral Diseases Research
                                    Avian Diseases and Oncology Research
                                    Return to USNPRC home pageSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Athens, Georgia U.S. National Poultry Research Center Exotic & Emerging Avian Viral Diseases Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Kapczynski, Darrellitem
                                            JIANG, HAI JUN - US Department Of Agriculture (USDA)
  Submitted to: American Association for Immunology
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 1/31/2013
                                    Publication  Date: 3/7/2013
                                    Citation: Kapczynski, D.R., Jiang, H. 2013. Genetic response and morphologic characterization of chicken bone-marrow derived dendritic cells during infection with high and low pathogenic avian influenza viruses. American Association for Immunology. p.3555.Interpretive Summary:
                                Technical Abstract: Dendritic cells (DC) are professional antigen-presenting cells of the immune system that function to initiate primary immune responses. Progenitors of DCs are derived from haematopoietic stem cells in the bone marrow (BM) that migrate in non-lymphoid tissues to develop into immature DCs. Here, they are specialized at capturing and processing antigen for immune presentation. Infection of chickens with avian influenza (AI) can result in a wide range of clinical disease, depending if the virus is of low or high pathogenicity. Low pathogenic (LP) AI viruses typically induce mild clinical signs, whereas highly pathogenic (HP) AI can result in death within days. In these studies, chicken BM-DCs were co-cultured with HPAI and LPAI of H5 and H7 subtype to determine the innate immune response, effect on cell morphology, and examine viral growth. A strong proinflammatory response, including interleukin-1beta, and stimulation of the interferon response pathway was observed at 8 hours post infection. Microscopically, the DCs altered their appearance after AI infection to a rounded shape, and eventually died, most likely through apoptosis. Differences in onset of morphologic changes were observed between H5 and H7 AI subtypes. Increases in viral titers demonstrated that both pathotypes of AI could replicate in BM-DCs. The increased DC activation following infection may be indicative of dysregulation of the immune response typically seen with HPAI infection.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov