U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Livestock Issues Research: Lubbock, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    NewsletterSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Lubbock, Texas Cropping Systems Research Laboratory Livestock Issues Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Sanchez, Nicoleitem
                                            BERNHARD, BRYAN - Texas Tech Universityitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            RATHMANN, RYAN - Texas Tech Universityitem
                                            JOHNSON, BRADLEY - Texas Tech University
  Submitted to: Innate Immunity
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 9/27/2011
                                    Publication  Date: 7/16/2012
                                    Citation: Sanchez, N.C., Bernhard, B.C., Carroll, J.A., Rathmann, R.R., Johnson, B.J. 2012. Enhancement of the acute phase response to lipopolysaccharide (LPS) challenge in steers supplemented with chromium. Innate Immunity. 18(4):592-601.Interpretive Summary: A collaborative effort between scientists as the Livestock Issues Research Unit and Texas Tech University was undertaken to determine the influence of chromium supplementation, supplemented as chromium propionate, on the immune status of steers in response to an intravenous challenge with endotoxin. Chromium has been demonstrated to decrease cortsiol concentrations, and thus it was hypothesized that chromium would enhance the acute innate immune response to endotoxin. Therefore, this study was designed to determine the affect of chroimum supplementation on the acute innate immune response of feedlot receiving steers to endotoxing challenge. Results from this study demonstrate that chromium can enhance the acute innate immune response to endotoxin challenge by increasing concentrations of tumor necrosis factor-alpha, interferon-gamma, and interleukin 6 above that of control steers. Additionally, steers supplemented with chromium produced a reduced rectal temperature and sickness behavior score response to endotoxin challenge. However, concentrations of cortisol did not differ between treatments. Future studies will need to determine the influence of chromium on aspects of energy and metabolism, including glucose, and insulin. These data suggest that chromium can be used as a supplement during the receiving period at a feedlot to help enhance innate immune functions and potentially expedite recovery. This information will be of interest to scientists working in the fields of innate immunity and nutritional supplementation.
                                Technical Abstract: The study examined the effect of chromium supplementation on the response of steers to an LPS challenge. Twenty steers received a premix that added 0 (control) or 0.2 mg/kg of chromium (KemTRACE®brandChromiumProprionate 0.04%, Kemin Industries) to the total diet on a dry matter basis for 55 d. Steers were fitted with jugular catheters and rectal temperature (RT) recording devices. Blood samples were collected relative to an LPS challenge (0.5 microgram/kg) and were also assigned sickness behavior scores. Prior-LPS, RT were greater in chromium-supplemented than control steers. Post-LPS RT increased in both treatments with control steers producing a greater change in RT than chromium-supplemented steers. Sickness behavior scores were greater in control than chromium-supplemented steers post-LPS. Cortisol concentrations did not differ between treatments pre-LPS. Post-LPS cortisol concentrations increased but did not differ due to treatment. Concentrations of IL-4 increased post-LPS but were not affected by treatment pre- or post-LPS. Treatment did not affect pre-LPS TNF-alpha and IFN-gamma. Post-LPS TNF-alpha and IFN-gamma increased, with chromium-supplemented steers producing greater TNF-alpha and IFN-gamma than control steers. Pre-LPS IL-6 was greater in chromium-supplemented than control steers. Post-LPS IL-6 increased and was greater in chromium-supplemented than control steers. These data suggests that chromium supplementation enhances the acute phase response of steers to an LPS challenge, which may expedite recovery.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov