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- Rebecca Milczarek *(Scopus)*
- Yuzhu Zhang *(PubMed)*

Title:   Author  item
                                            HUNG, SHAO-CHING - Dow Chemical Companyitem
                                            Yokoyama, Wallace

                                                         - *Wally*item
                                            KIM, HYUNSOOK - University Of Californiaitem
                                            Bartley, Glennitem
                                            ANDERSON, WILLIAM H - Dow Chemical Companyitem
                                            ALBERTS, DAVID - Dow Chemical Companyitem
                                            LANGHORST, MARSHA - Dow Chemical Companyitem
                                            WILLIAMS, DAVID - Dow Chemical Companyitem
                                            STOTT, WILLIAM - Dow Chemical Companyitem
                                            TUROWSKI, MACIEJ - Dow Chemical Company
  Submitted to: Journal of Agricultural and Food Chemistry
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 10/18/2012
                                    Publication  Date: 10/19/2012
                                    Citation: Hung, S., Yokoyama, W.H., Kim, H., Bartley, G.E., Anderson, W.K., Alberts, D.R., Langhorst, M.L., Williams, D.M., Stott, W., Turowski, M. 2012. HPMC supplementation reduces abdominal fat content, intestinal permeability, inflammation, and insulin resistance in diet-induced obese mice. Journal of Agricultural and Food Chemistry. 60(44):11149-11156.Interpretive Summary: We evaluated a new type of soluble dietary fiber.  Unlike most natural fibers that have are neutral or have a negative electrical charge, cationic hydroxyethyl cellulose (CHEC) has a positive charge.  We found that in fat fed obese hamsters, CHEC reduced weight gain and particularly abdominal adipose weight gain.  CHEC also lowered plasma and liver cholesterol. These results suggest that CHEC may be useful in preventing obesity related chronic diseases.
                                Technical Abstract: Cationic hydroxyethyl cellulose (cHEC) , was fed to hamsters to determine if this new soluble fiber had an effect on hypercholesterolemia and dyslipidemia associated with cardiovascular disease.  In this study, Golden Syrian hamsters were supplemented with 3-8% cHEC or microcrystalline cellulose (MCC; control) in diets containing 39% energy from fat for four weeks. Supplementation of cHEC in a high-fat diet led to significant weight gain reduction in hamsters. In addition, significant decreases in adipose and liver weights, concentrations of plasma total-, VLDL-, and LDL-cholesterol, and hepatic lipids were shown.  No significant improvements in glucose and insulin levels were observed with cHEC,  however, a significant increase in plasma adiponectin and a decrease in leptin were observed. Compared with controls, cHEC-fed hamsters had greater levels of mRNA for CYP7A1 (cytochrome P450 7A1; 2-fold of control; P < 0.05), CYP5.1  (lanosterol 14a-demethylase; 6-fold of control; P < 0.05), and LDLR (LDL receptor; 1.5-fold of control) in the liver.  These findings suggest the possibility of the use of cHEC for cholesterol reduction and beneficial effects on the cardiovascular risk factors.


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