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ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





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Title:   Author  item
                                            MARGOLIS, LEE - Us Army Researchitem
                                            Cao, Jayitem
                                            SAUTER, EDWARD - University Of North Dakotaitem
                                            Whigham Grendell, Leahitem
                                            MCCLUNG, JAMES - Us Army Researchitem
                                            Combs, Geralditem
                                            YOUNG, ANDREW - Us Army Researchitem
                                            PASIAKOS, STEFAN - Us Army Research
  Submitted to: Federation of American Societies for Experimental Biology Conference
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 11/14/2011
                                    Publication  Date: 9/29/2012
                                    Citation: Margolis, L.M., Cao, J.J., Sauter, E.R., Whigham Grendell, L.D., Mcclung, J.P., Combs, G.F., Young, A.J., Pasiakos, S.M. 2012. A high protein diet upregulated whole-body protein turnover during energy deficit. Federation of American Societies for Experimental Biology Conference. 26:1013.3.Interpretive Summary:
                                Technical Abstract: The effects of higher protein diets and sustained energy deficit (ED) on whole-body protein turnover (WBPTO) are not well described.  This study examined whether dietary protein level influences whole-body protein breakdown (Ra), non-oxidative leucine disposal (NOLD), and oxidation (Ox) during ED.  Using a randomized-block design, 24 males and five females (21 ± 3 yr) participated in a controlled trial.  Volunteers consumed either standard (SP; 0.8 g•kg-1•d-1), moderate (MP; 1.6 g•kg-1•d-1), or high (HP; 2.4 g•kg-1•d-1) protein diets for 31 days.  A weight maintenance (WM, days 1-10) period was followed by 21 days of ED (days 11-31) equal to 40% of total daily energy expenditure.  Resting WBPTO (μmol•kg-1·h-1) was determined during WM (day 10) and ED (day 31) using primed, continuous [13C]-leucine infusions.  Volunteers lost (P < 0.05) ~ 3.3 ± 1 kg in response to ED regardless of protein level.  Ra was decreased (P < 0.05) in response to ED for SP and MP diets, but did not change for HP.  NOLD was decreased (P < 0.05) following ED regardless of protein level.  Ox increased linearly between SP (9.7 ± 0.5), MP (11.8 ± 0.5), and HP (13.9 ± 0.5) diets during WM, with increased Ox observed only for HP (16 ± 0.7) during ED (diet-by-energy interaction, P < 0.05).  These data demonstrate that sustained ED and level of dietary protein intake modulate WBPTO, as consumption of a high protein diet upregulates WBPTO during ED.


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