U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Location Research Units
                        National Sedimentation Laboratory
                                    Natural Products Utilization Research Unit
                                    Water Quality and Ecology Research Unit
                                    Watershed Physical Processes Research UnitSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            ZHELIJAZKOV, VALTCHO - Wyoming Research Extension Serviceitem
                                            Cantrell, Charlesitem
                                            DONEGA, MATEUS - Sao Paulo State University (UNESP)item
                                            ASTATKIE, TESS - Nova Scotia Agricultural College
  Submitted to: Industrial Crops and Products
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/1/2012
                                    Publication  Date: 1/15/2013
                                    Citation: Zhelijazkov, V.D., Cantrell, C.L., Donega, M.A., Astatkie, T. 2013. Bioprospecting for podophyllotoxin in the Big Horn Mountains, Wyoming. Industrial Crops and Products. 43:787-790.Interpretive Summary: Podophyllotoxin is a natural product used as a chemical precursor for the anti-cancer drugs etoposide and teniposide.  These compounds, are used for the treatment of lung cancer, testicular cancer, neuroblastoma, hepatoma.  Currently, there is a large international demand for podophyllotoxin.  The objective of this study was to evaluate variations in podophyllotoxin concentrations in Juniperus species found in the Big Horn Mountains in Wyoming.  It was found that Juniperus species in the Big Horn Mountains included three species; J. communis L. (common juniper), J. horizontalis Moench. (creeping juniper) and J. scopulorum Sarg. (Rocky Mountain juniper).  The range of concentrations in podophyllotoxin in J. horizontalis and J. scopulorum in the Big Horn Mountains were within the range or (in case of J. horizontalis), much higher than the ones reported previously for J. virginiana. This is the first report on podophyllotoxin in J. horizontalis. The concentrations of podophyllotoxin in some accessions of J. horizontalis were twice as high as the ones reported previously for any other Junipers.  This study demonstrated that Juniperus species in the Big Horn Mountains have a potential to be used as a source for podophyllotoxin.
                                Technical Abstract: The objective of this study was to evaluate variations in podophyllotoxin concentrations in Juniperus species found in the Big Horn Mountains in Wyoming.  It was found that Juniperus species in the Big Horn Mountains included three species; J. communis L. (common juniper), J. horizontalis Moench. (creeping juniper) and J. scopulorum Sarg. (Rocky Mountain juniper). Of these species, none of the 36 accessions of J. communis contained detectable amounts of podophyllotoxin.  All accessions of J. scopulorum but one contained podophyllotoxin.  Podophyllotoxin concentration in J. horizontalis and J. scopulorum did not correlate to the elevation of the selection sites. The concentration of podophyllotoxin in J. scopulorum ranged from 0 to 0.40 %, while the concentration of podophyllotoxin in in J. horizontalis ranged from 0.27 to 0.73 %. Overall, J. horizontalis accessions in the Big Horn Mountains showed higher concentration of podophyllotoxin than the one in J. scopulorum. The range of concentrations in podophyllotoxin in J. horizontalis and J. scopulorum in the Big Horn Mountains were within the range or (in case of J. horizontalis), much higher than the ones reported previously for J. virginiana. This is the first report on podophyllotoxin in J. horizontalis. The concentrations of podophyllotoxin in some accessions of J. horizontalis were twice as high as the ones reported previously for any other Junipers.  This study demonstrated that Juniperus species in the Big Horn Mountains have a potential to be used as a source for podophyllotoxin.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov