U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Dairy and Functional Foods Research: Wyndmoor, PA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    About ERRC
                        Greetings from the Director
                                    Directions/Lodging
                                    History and Accomplishments
                    Our Work
                        Biomass Pyrolysis Research
                                    IPMP 2013
                                    IPMP Dynamic Prediction
                                    IPMP Global Fit
                                    Pathogen Modeling Program (PMP)
                                    Predictive Microbiology Information Portal (PMIP)
                                    PoultryFARMSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Wyndmoor, Pennsylvania Eastern Regional Research Center Dairy and Functional Foods Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            BOBKALONOV, D. - Tajikistan Academy Of Sciencesitem
                                            KASYMOVA, G. - Tajikistan Academy Of Sciencesitem
                                            MUKHIDINOV, Z. - Tajikistan Academy Of Sciencesitem
                                            DZHONMURODOV, A. - Tajikistan Academy Of Sciencesitem
                                            KHALIKOV, D. - Tajikistan Academy Of Sciencesitem
                                            Liu, Linshu
  Submitted to: Pharmaceutical Chemistry Journal
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/8/2012
                                    Publication  Date: 5/1/2012
                                    Citation: Bobkalonov, D.T., Kasymova, G.F., Mukhidinov, Z.K., Dzhonmurodov, A.S., Khalikov, D.K., Liu, L.S. 2012. Kinetics of piroxicam release from low-methylated pectin/zein hydrogel microspheres. Pharmaceutical Chemistry Journal. 46(1):50-53.Interpretive Summary: Sunflower is a major cash-crop in Tajikistan. Pectin can be extracted from sunflower head residues after sunflower oil extraction. We have demonstrated that pectin can form complex hydrogels with corn protein. The resultant hydrogels can be used as a drug carrier for colon-specific drug delivery via oral route. The present study evaluated the release kinetics in the conditions mimicking the environments from the mouth to the gut. The drug diffusion out from the microspheres was identified as rate-limiting step in the release mechanism rather than its dissolution. The research provides a base to fabricate pectin-derived hydrogel drug delivery systems with a programmed released rate by tailoring the chemical compositions and physical architecture of the hydrogels.
                                Technical Abstract: The kinetics of a model drug (piroxicam) release from pectin/zein hydrogel microspheres was studied under conditions simulating the gastrointestinal tract.  It is established that the rate-limiting step in the release mechanism is drug diffusion out of the microspheres rather than its dissolution.  The results demonstrate the effectiveness of using this system based on hydrogel microspheres as a sustained drug delivery system capable of prolonging drug release for a period of 36 h and more with allowance for diffusion and enzymatic biodegradation in the hydrogel.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov