U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Ruminant Diseases and Immunology Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Ruminant Diseases and Immunology Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Sacco, Randyitem
                                            Waters, Wadeitem
                                            Palmer, Mitchellitem
                                            Nonnecke, Brian
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/30/2010
                                    Publication  Date: 10/1/2010
                                    Citation: Sacco, R.E., Waters, W.R., Palmer, M.V., Nonnecke, B.J. 2010. Modeling Bovine Respiratory Syncytial Virus Infection [abstract]. The Association for Veterinary Teaching and Research Work. p. 6.Interpretive Summary:
                                Technical Abstract: Bovine respiratory disease (BRDC) is a leading cause of morbidity and mortality in calves in U.S. beef feedlots. Furthermore, it is the leading cause of weaned dairy heifer mortality and one of the primary causes of mortality in pre-weaned dairy calves. While the mechanisms leading to BRDC remain to be elucidated, it likely involves interactions of infectious agents, host immune modulation, and physiological stress due to management practices. Viral infection is almost always a primary infectious insult. Common viral agents include bovine herpes virus (BHV)-1, bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), and bovine respiratory coronavirus (BRCV). Subsequently, opportunistic bacterial infections result in an exacerbation of lung pathology. Primary bacterial agents in BRDC include Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis. We have developed two models of viral infection, intratracheal and aerosol, using BRSV in calves up to 2 months of age. Earlier studies involved the use of intratracheal inoculation. In that model, 60-70% of the animals typically developed gross and microscopic lesions indicative of BRSV infection. More recently, we have developed an aerosol challenge model for BRSV, which more consistently produces lesions characteristic of natural BRSV infection in calves. Gross lesions included areas of multifocal consolidation and atelectasis. Microscopically, there was a necrotizing bronchiolitis and interstitial pneumonia with syncytial cells observed. This model will be useful for studies of viral-bacterial interactions as well as testing novel vaccines for BRSV.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov