U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Range Sheep Production Efficiency Research: Dubois, ID
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Pacific West Area Dubois, Idaho Range Sheep Production Efficiency Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- IACUC Summary

Title:   Author  item
                                            YUNUSOVA, ROZA - North Dakota State Universityitem
                                            NEVILLE, TAMMI - North Dakota State Universityitem
                                            VONNAHME, KIMBERLY - North Dakota State Universityitem
                                            HAMMER, CAROLYN - North Dakota State Universityitem
                                            REED, JAKE - North Dakota State Universityitem
                                            Taylor, Joshua

                                                         - *Bret*item
                                            REDMER, DALE - North Dakota State Universityitem
                                            REYNOLDS, LAWRENCE - North Dakota State Universityitem
                                            CATON, JOEL - North Dakota State University
  Submitted to: Journal of Animal Science
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/17/2013
                                    Publication  Date: 5/1/2013
                                    Citation: Yunusova, R., Neville, T.L., Vonnahme, K.A., Hammer, C., Reed, J., Taylor, J.B., Redmer, D.A., Reynolds, L.P., Caton, J.S. 2013. Impacts of maternal selenium supply and nutritional plane on visceral tissues and intestinal biology in 180-day-old offspring in sheep. Journal of Animal Science. 91:2229-2242.Interpretive Summary: Recently, we have demonstrated the advantages of feeding diets naturally rich in selenium to ruminant livestock. Critics have expressed concern about the potential for selenium toxicity at the dietary levels of selenium that we have proposed in the past. These results clearly demonstrate that selenium, from natural selenium-rich feeds, fed at 10-fold the recommended requirement is safe and nutritious for the pregnant ewe and developing fetus.
                                Technical Abstract: Objectives were to investigate the effects of maternal Se supply and nutritional plane during gestation on offspring visceral tissues and indices of intestinal growth, vascularity, and function at 180 d of age. Rambouillet ewe lambs (n = 82, approximately 240 d of age; 52 ± 0.8 kg BW at breeding) were allocated to a 2 × 3 factorial arrangement of treatments. Treatments included dietary Se (adequate Se [ASe, 9.5 μg/kg BW] or high
31 Se [HSe, 81.8 μg/kg BW]) initiated at breeding and nutritional plane (60% [restricted, RES], 100% [control, CON], and 140% [ high, HI] of requirements) initiated at d 50 of gestation. Ewes were fed pelleted diets and housed individually indoors. At parturition, lambs were immediately removed and fed artificial colostrum for the first 20 h followed by ad libitum access to milk replacer. At 180 ± 2 d of age, lambs were euthanized and
36 tissues harvested. Birth weight was affected by nutritional treatments (P < 0.001) with decreased birth weight in RES and HI compared with CON. Offspring from RES and HI ewes had decreased (P = 0.07) blood volume compared to CON, and those born to HSe ewes had increased (P < 0.04) total visceral adiposity. Within offspring from CON ewes,
40 those from HSe ewes had greater (P < 0.02) intestinal mass compared with ASe ewes. Within offspring from HSe ewes, both RES and HI had reduced (P = 0.05) intestinal mass compared with CON. Jejunal capillary area density was greater (P = 0.08) in offspring from ewes fed HSe compared with ASe. In addition, area per capillary was
44 greater (P = 0.09) in CON compared with RES. Maternal nutritional plane tended (P = 0.11) to alter total small intestinal vascularity, with lambs from CON being greater than RES. Expression of most mRNA for measured angiogenic factors and receptors was not altered (P = 0.13) by maternal treatments; however expression of glucagon like peptide -2 (GLP-2) was lower (P = 0.07) in offspring from RES compared with CON ewes. Offspring from ewes fed HI diets had increased (P = 0.08) jejunal mucosal maltase activity. In conclusion, maternal Se supply and nutritional plane during gestation resulted in measurable changes in offspring visceral tissues and intestinal biology including
52 perirenal fat, blood volume, intestinal mass, total jejunal crypt cell proliferation, area per capillary in jejunal villi, GLP-2 mRNA expression, and maltase activity at 180 d. Additional work is needed to determine impacts on intestinal function and nutrient uptake.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov