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Title:   Author  item
                                            PICCOLO, BRIAN - University Of Californiaitem
                                            Gertz, Erikitem
                                            THOMAS, ANTHONY - University Of Californiaitem
                                            Keim, Nancyitem
                                            Adams, Seanitem
                                            SEYOUM, ELIAS - Jean Mayer Human Nutrition Research Center On Aging At Tufts Universityitem
                                            Dolnikowski, Gregoryitem
                                            Van Loan, Marta
  Submitted to: Journal of Federation of American Societies for Experimental Biology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 2/1/2012
                                    Publication  Date: 3/29/2012
                                    Citation: Piccolo, B.D., Gertz, E.R., Thomas, A.P., Keim, N.L., Adams, S.H., Seyoum, E., Dolnikowski, G., Van Loan, M.D. 2012. Association between vitamin D metabolites in fat tissue and serum 25-hydroxy vitamin D in overweight and obese adults. Journal of Federation of American Societies for Experimental Biology. 386.4.Interpretive Summary:
                                Technical Abstract: Cholecalciferol has been measured in human white adipose tissue (WAT), but little is known about the relationship between the other circulating vitamin D metabolites and WAT.  We measured concentrations of 25(OH)D and 1,25(OH)2D in subcutaneous fat tissue from 20 overweight and obese subjects participating in a weight loss intervention (Van Loan, 2011).  WAT biopsies were obtained pre- and post-intervention from the gluteal region and were analyzed for 25(OH)D and 1,25(OH)2D by LC/MS/MS (Blum, 2008). Serum 25(OH)D and 1,25(OH)2D were measured by RIA. Mean adipose 25(OH)D concentrations were 2.24 ± 1.0 ng/g pre- and 2.39 ± 1.1 ng/g post-intervention, but 1,25(OH)2D concentrations were undetectable.  Pre- and post-intervention WAT 25(OH)D concentrations were correlated (r = 0.5482, P = 0.0185) and there was a significant positive association between subcutaneous fat 25(OH)D concentrations and serum 25(OH)D concentrations (r = 0.5140, P = 0.0011) across a range of body weight and adiposity. This suggests that similar to the parent compound, 25(OH)D deposition in human WAT is directly dependent on circulating 25(OH)D.  The active compound, 1,25(OH)2D, may not be stored in appreciable amounts.  

Funding: National Dairy Council; USDA, ARS, WHNRC; Dairy Council of California; CTSC, University of California (1M01RR19975-01), National Center for Medical Research (UL1 RR024146)


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