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Title:   Author  item
                                            KIM, DUK-KYUNG - US Department Of Agriculture (USDA)item
                                            Lillehoj, Hyunitem
                                            LEE, KYUNG-WOO - US Department Of Agriculture (USDA)item
                                            PARK, MYEONG-SEON - US Department Of Agriculture (USDA)item
                                            SIRAGUSA, GREGORY - Danisco Usa, Inc
  Submitted to: BARC Poster Day
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/7/2011
                                    Publication  Date: 4/18/2011
                                    Citation: Kim, D., Lillehoj, H.S., Lee, K., Park, M., Siragusa, G.R. 2011. Transcriptome profiles of chicken intestinal intraepithelial lymphocytes altered by the intake of a multi-strain direct-fed microbials. BARC Poster Day. P. 20.Interpretive Summary:
                                Technical Abstract: The current study was conducted to investigate the effects of the direct-fed microbials (DFM) including three Bacillus subtilis strains on the modulation of transcriptional profile in chicken intestinal intraepithelial lymphocytes (IEL).  The multiple-strain DFM product modified 453 probes from 1,985 microarray elements with above 2.0-fold up- or down changes in chicken IEL when they’re compared with non-treated controls and those modulations were closely associated with the biological functions of lipid metabolism and the interaction between pro-inflammatory cytokine activated by lipopolysaccharide (LPS) and lipid metabolic modulation. Macrophage activation induced by the DFM treatment was also accessed by measuring nitric oxide (NO) levels in cultures of LPS-stimulated splenocytes. The results suggested that the uptake of multi-strain DFM augment the innate immune system against the infection by enteric pathogens.  Future studies to identify novel functions and/or potential anti-pathogenic effects of DFMs as the feed additives based upon these results may now be feasible.


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