Custom Synthesis Agreement, dated March 14, 1996



 Exhibit 10.20 
 [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
BRACKETS, HAS BEEN OMITTED AND FILED WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

  

			
	 [ * ]
	  	 [ * ]


 CUSTOM SYNTHESIS AGREEMENT 
  

			
	CUSTOMER	  	Steritech, Concord, USA.
		
	PROCESS	  	Production of S-59.

 The following are the general terms and conditions covering the above conversion: 
  

	1.	All work is undertaken under Confidentiality Agreement. 

  

	2.	All work will be carried out in accordance with GMP. 

  

	3.	Except as expressly stated process details will be supplied by Steritech and [ * ] do not guarantee yields or quality of product produced save to the extent that yields or
quality are substantially affected by the negligence or willful misconduct or [ * ] personnel. 

  

	4.	The project supervisors who are authorised to contract the work and to whom all reports should be furnished are: 

  

	  	Steritech             :             Dr. Susan Wollowitz



	  	[ * ]     :             [ * ] 

  

	5.	Written reports will be furnished to Steritech in a manner and timescale agreed between the project supervisors. 

  

	6.	[ * ] will undertake to: 

  

	 	a.	convert two batches of a minimum of 15 kgs each of [ * ] to S-59 in a campaign using a combination of our multi-purpose glass lined plant and out [ * ] pilot plant,


  

	 	b.	provide analytical support for the production campaign at [ * ]  

  

	 	c.	isolate and handle the final product in a controlled environment, 

  

	 	d.	clean down the plant after the second batch of S-59 and after each recrystallisation. 

  

	7.	Steritech are responsible for supplying 30 kgs or [ * ] of the required quality to [ * ] before 1 April 1996. The minimum batch size which can be processed by
[ * ] is 15kgs of [ * ] per batch. Should the campaign not take place due to non availability or non suitability of starting material at the reserved time and [ * ] is unable to fill the production slot, Steritech will be
responsible for the charges under this proposal. 

  

	8.	Steritech, by virtue of contracting this work, will own all intellectual property generated directly from the work and [ * ] will co-operate in any reasonable manner in
transferring the intellectual property to Steritech. [ * ] will charge Steritech at standard rates for all time expended on this work. 











			
	 [ * ]
	  	 [ * ]


  

	9.	[ * ] will carry out the testing of the final product in accordance with TS295 (copy appended) 

  

	10.	The costs for the work to be undertaken under this project will be as follows: 

  

			
	 10.1     Conversion Cost
	  	IR£98,500
		
	 10.2     Chemist Time
	  	
		
	 Any development work requested will be charged at the following rates:
	  	
	 Senior Chemist
	  	[ * ] per week
	 Development Chemist
	  	[ * ] per week

  

	  	10.3    Materials and Other 

  

	  	Materials and outside analytical services, which will only be contracted from [ * ] approved vendors, will be charged at cost to [ * ] plus 10% to cover
administration. Any other out of pocket expenses will be charged at cost 

  

	 	10.4	    Invoicing 

  

	  	Work will only be undertaken on receipt of a written purchase order from Steritech. Invoices will be raised at the end of the production campaign and will be due for payment within
30 days from date of invoice by way of transfer of funds to a bank account nominated on the invoice. Charges will be supported by appropriate documentation which will be available on request for inspection at [ * ] premises.


  

	
	/s/ [ * ]
	[ * ]
	Finance Director

 Accepted for and on behalf of Steritech Inc.: 
  

					
			
	 /s/ Stephen Isaacs
	  	Stephen Isaacs	 	3/14/96
	Signature	  	Print Name	 	Date

 [ * ] = CERTAIN CONFIDENTIAL INFORMATION
CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF
THE SECURITIES ACT OF 1933, AS AMENDED.