U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            HOU, YALI - University Of Marylanditem
                                            Bickhart, Derekitem
                                            FANG, XIN - Food And Drug Administration(FDA)item
                                            SONG, JIUZHOU - University Of Marylanditem
                                            Van Tassell, Curtis

                                                         - *Curt*item
                                            Sonstegard, Taditem
                                            SEROUSSI, EYAL - Collaboratoritem
                                            Liu, Ge

                                                         - *George*
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 9/23/2011
                                    Publication  Date: 10/20/2011
                                    Citation: Hou, Y., Bickhart, D.M., Fang, X., Song, J., Van Tassell, C.P., Sonstegard, T.S., Seroussi, E., Liu, G. 2011. Copy number variations related to reproduction traits in Holstein cattle. Meeting Abstract. No. 7.Interpretive Summary:
                                Technical Abstract: Daughter pregnancy rate (DPR) is one of important reproduction traits that affect overall profitability in dairy industry. However, historical selection for production and conformation rather than reproduction has resulted in a decline in cow fertility. Genomic structural variation including copy number variation (CNV) is an important and abundant source of genetic variation. In this study, we investigated CNVs associated with DPR. Based on array comparative genomic hybridization and qPCR, we performed a CNV analysis using 40 Holstein bulls with either high or low predicted transmitting ability of DPR (referred as HDPR or LDPR group). We identified 685 (16.4 Mb) and 656 (17.8 Mb) CNV regions from HDPR and LDPR groups respectively. The HDPR CNV regions overlapped with 376 ensembl genes, while the LDPR CNV regions contained 405 ensembl genes. A total of 56% of the CNV regions were specific to either HDPR or LDPR group. It is intriguing to notice that IPA analysis based on the CNV associated genes revealed several significant networks related to reproductive system development and function, and embryonic development in HDPR. We also discovered the genes which over represented in both HDPR and LDPR for molecular function of reproductive system and embryonic development, including PSG, CEACAM1, PDE4D, PRKCA and SERPINB5. In addition, the common “loss” CNV events at gene PGR could reflect the high selection pressures on milk production traits in Holstein cattle. These results indicate that some CNV associated genes may be associated with reproduction trait such as DPR.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov