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Title:   Author  item
                                            JANG, SEUNG - US Department Of Agriculture (USDA)item
                                            Lillehoj, Hyunitem
                                            Lee, Sungitem
                                            LEE, KYUNG-WOO - US Department Of Agriculture (USDA)item
                                            PARK, MYEONG-SEON - US Department Of Agriculture (USDA)item
                                            Bauchan, Garyitem
                                            LILLEHOJ, ERIK - University Of Marylanditem
                                            BERTRAND, FRANCOIS - Seppic, Incitem
                                            DUPUIS, LAURENT - Seppic, Incitem
                                            DEVILLE, SEBASTIEN - Seppic, Inc
  Submitted to: BARC Poster Day
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/7/2011
                                    Publication  Date: 4/18/2011
                                    Citation: Jang, S.I., Lillehoj, H.S., Lee, S.H., Lee, K., Park, M., Bauchan, G.R., Lillehoj, E., Bertrand, F., Dupuis, L., Deville, S. 2011. Immunoenhancing effects of MontanideTM ISA oil-based adjuvants on recombinant coccidia antigen vaccination against Eimeria acervulina infection. BARC Poster Day. P.20.Interpretive Summary:
                                Technical Abstract: The current study was conducted to investigate the immunoenhancing effects of Montanide' adjuvants on protein subunit vaccination against avian coccidiosis. Broiler chickens were immunized subcutaneously with a purified Eimeria acervulina recombinant profilin protein, either alone or mixed with one of four adjuvants (ISA 70 VG, ISA 71 VG, ISA 201 VG or ISA 206 VG). Following an oral challenge infection with live E. acervulina oocysts, body weight gains, fecal oocyst shedding, and humoral and innate immune responses were evaluated. Immunization with profilin plus ISA 70 VG or ISA 71 VG increased body weight gains compared with vaccination with profilin alone. Profilin plus ISA 71 VG also reduced fecal oocyst shedding compared with vaccination in the absence of adjuvant. Profilin serum antibody titers were enhanced with all adjuvants. Increased levels of gene transcripts encoding IL-2, IL-10, IL-17A, and IFN-', but decreased levels of IL-15 mRNAs, were observed in intestinal intraepithelial lymphocytes of chickens immunized with profilin plus adjuvants compared with immunization with profilin alone. Finally, increased infiltration of lymphocytes, especially CD8+ lymphocytes at the site of immunization, was observed in broilers given profilin plus ISA 71 VG compared with profilin alone. These results demonstrate that vaccination with the E. acervulina profilin subunit vaccine in combination with MontanideTM adjuvants enhances protective immunity against avian coccidiosis.


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