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Title:   Author  item
                                            BOZIC, ALEKSANDAR - University Of Novi Saditem
                                            Anderson, Robinitem
                                            Callaway, Todditem
                                            Nisbet, Daviditem
                                            RICKE, STEVE - University Of Arkansasitem
                                            CRANDALL, PHIL - University Of Arkansasitem
                                            O'BRYAN, CORLISS - University Of Arkansas
  Submitted to: International Journal of Applied Research in Veterinary Medicine
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 9/13/2010
                                    Publication  Date: 9/14/2010
                                    Citation: Bozic, A., Anderson, R.C., Callaway, T.R., Nisbet, D.J., Ricke, S., Crandall, P., O'Bryan, C. 2010. In vitro comparison of nitroethane, 2-nitro-1-propanol, lauric acid, lauricidin(R), and the Hawaiian marine algae, Chaetoceros, activity against anaerobically grown Staphylococcus aureus. International Journal of Applied Research in Veterinary Medicine. 8:180-184.Interpretive Summary: Cattle are subject to mastitis, an infection of the mammary gland, that is very economically impactful to dairy producers in the U.S.  Mastitis is often caused by the bacterium Staphylococcus aureus, which can live in the gut of cattle.  A series of methane inhibitors that have been proposed for use to improve cattle feed efficiency were tested for their inhibitory effect against S. aureus.  The commercial product Lauricidin®, which is a monoglycerol ester of lauric acid, showed the greatest effectiveness against S. aureus, suggesting a potential role as a non-antibiotic treatment against mastitis.
                                Technical Abstract: Mastitis is a common illness of dairy cattle and is very costly, economically, to the dairy farmer.  Thus, there is a need to develop broad-spectrum therapies that are effective while not leading to unacceptably long antibiotic withdrawal times.  The effects of the CH4-inhibitors nitroethane (2 mg/ml), 2-nitro-1-propanol (2 mg/ml), lauric acid (5 mg/ml), the commercial product Lauricidin® (5 mg/ml), and a finely-ground product of the Hawaiian marine algae, Chaetoceros (10 mg/ml), were compared in pure cultures of S. aureus.  Lauricidin® exhibited the most bactericidal acidity against S. aureus. These results suggest potential for treatments with a non-antibiotic compound could be effective against mastitis.


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