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ARS Home Northeast Area Wyndmoor, Pennsylvania Eastern Regional Research Center Dairy and Functional Foods Research Research Publications at this Location





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Title:   Author  item
                                            MUHIDINOV, Z - Tajikistan Academy Of Sciencesitem
                                            KASIMOVA, G - Tajikistan Academy Of Sciencesitem
                                            BOBOKALONOV, J - Tajikistan Academy Of Sciencesitem
                                            KHALIKOV, D - Tajikistan Academy Of Sciencesitem
                                            TESHAEV, KH - Tajikistan Academy Of Sciencesitem
                                            KHALIKOVA, M - Tajikistan Academy Of Sciencesitem
                                            Liu, Linshu
  Submitted to: Journal of Chemical and Pharmaceutical Research   
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/1/2010
                                    Publication  Date: 12/1/2010
                                    Citation: Muhidinov, Z.K., Kasimova, G.F., Bobokalonov, J.T., Khalikov, D.K., Teshaev, K.I., Khalikova, M.D., Liu, L.S. 2010. Pectin/zein microspheres as a sustained drug delivery system. Journal of Chemical and Pharmaceutical Research. 44(9):20-24.Interpretive Summary: Polysaccharide/protein microspheres have been used for oral drug delivery for decades. These drug carriers from naturally occurring biopolymers are biocompatible and biodegradable, and widely accepted by consumers. However, properties of biopolymers vary with growth environments and processing conditions. Microspheres prepared from biopolymers from different resources (provider, batch, origin of raw materials, etc) often change their  properties, even they are produced with the same procedure and under the same operating conditions. As a result, the release of encapsulated bioactives from the microspheres couldn’t be well controlled. This has limited the applications of microspheres in medical and pharmaceutical areas. This study compared the chemical and physical properties of microspheres using three different pectins with the same apparent molecular weight and degree of esterification. The results obtained from this preliminary study are useful in the design and fabrication of such microspheres.
                                Technical Abstract: A series of microspheres were prepared from pectins and corn proteins from various sources in the presence of the divalent ions calcium or zinc. The results showed that the yield of microsphere and the efficiency of drug incorporation were dependent on the type and ratio of biopolymers, the size of the divalent cations, as well as the molecular weight of the biopolymer used. There were two mechanisms that govern microsphere formation: ionic interaction between the metal ions and the carboxyl groups on pectin chains, and hydrophobic interaction of chain-chain entanglement between the polysaccharide and the protein.


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