U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Dietary Prevention of Obesity-related Disease Research: Grand Forks, ND
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Grand Forks, North Dakota Grand Forks Human Nutrition Research Center Dietary Prevention of Obesity-related Disease Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            SHEN, CHWAN-LI - Texas Tech Universityitem
                                            Cao, Jayitem
                                            DAGDA, RAUL - Texas Tech Universityitem
                                            CHANJAPLAMMOOTIL, SAMUEL - Texas Tech Universityitem
                                            LU, CHUWANWEN - Texas Tech Universityitem
                                            CHYU, MING-CHIEN - Texas Tech Universityitem
                                            GAO, WEIMIN - Texas Tech Universityitem
                                            WANG, JIA-SHENG - University Of Georgiaitem
                                            YEH, JAMES - Winthrop University Hospital
  Submitted to: Nutrition Research
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/18/2012
                                    Publication  Date: 6/8/2012
                                    Citation: Shen, C., Cao, J.J., Dagda, R., Chanjaplammootil, S., Lu, C., Chyu, M., Gao, W., Wang, J., Yeh, J.K. 2012. Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats. Nutrition Research. 32:448-457.Interpretive Summary: Obesity and osteoporosis are two major health disorders in the USA. We investigated the effects of green tea polyphenols (green tea bioactive components) on body composition and bone metabolism in a high-fat diet induced obesity animal model. 
We found that supplementation green tea polyphenols for 4 months increased fat-free mass, bone mineral content, bone mineral density and bone strength. Our data demonstrate that green tea polyphenols are useful in preventing obesity and are beneficial to bone development.
                                Technical Abstract: This study investigated the effects of green tea polyphenols (GTP) on body composition and 2 bone properties in obese female rats. Thirty-six 3-month-old SD female rats were fed either a 3 low-fat (LF) diet (n = 12) or a high-fat (HF) diet (n= 24) for 4 months. Animals in the LF diet 4 group continued on an LF diet for additional 4 months, while those in the HF diet group were 5 divided into 2 groups, with 0.5% (wt/vol) or without GTP in drinking water, in addition to an HF 6 diet for another 4 months. Body composition [body weight (BW), fat mass (FM), fat-free mass 7 (FFM), total body water (TBW), intracellular fluid (ICF), and extracellular fluid (ECF)] was 8 measured by bioimpedance spectroscopy. Bone parameters [femoral bone area, mineral content 9 (BMC) and density (BMD)] were measured by dual-energy x-ray absorptiometry. Bone strength, 10 serum proinflammatory cytokines levels, and liver glutathione peroxidase (GPX) activity and 11 protein expression were also determined. After 8 months, compared to the LF diet, the HF diet 12 increased BW, %FM, and ECF/ICF ratio, reduced %FFM, %TBW, GPX activity and protein 13 expression, and bone strength, but had no effect on BMC and BMD in the rats. GTP 14 supplementation for 4 months increased %FFM, BMC, BMD, bone strength, and GPX activity 15 and protein expression, and decreased %FM, the ECF/ICF ratio and cytokines in HF-diet-16 induced obese rats. This study demonstrates that GTP supplementation in drinking water for 4 17 months modifies body composition and enhances bone properties in obese rats through 18 suppressing inflammation and enhancing antioxidant capacity.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov