U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Dairy and Functional Foods Research: Wyndmoor, PA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    About ERRC
                        Greetings from the Director
                                    Directions/Lodging
                                    History and Accomplishments
                    Our Work
                        Biomass Pyrolysis Research
                                    IPMP 2013
                                    IPMP Dynamic Prediction
                                    IPMP Global Fit
                                    Pathogen Modeling Program (PMP)
                                    Predictive Microbiology Information Portal (PMIP)
                                    PoultryFARMSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Wyndmoor, Pennsylvania Eastern Regional Research Center Dairy and Functional Foods Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            KHALIKOVA, M - Tajikistan Academy Of Sciencesitem
                                            RAKHIMOV, E - Tajikistan Academy Of Sciencesitem
                                            BABOKALONOV, D - Tajikistan Academy Of Sciencesitem
                                            MUHIDINOV, Z - Tajikistan Academy Of Sciencesitem
                                            Liu, Linshu
  Submitted to: Journal of Academy of Sciences of the Republic of Tajikistan
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/19/2009
                                    Publication  Date: 1/6/2010
                                    Citation: Khalikova, M.D., Rakhimov, E.F., Babokalonov, D.T., Muhidinov, Z.K., Liu, L.S. 2010. Biocompatibility of Pectin-Protein Gels and Microencapsulates: In Vivo Study on Rats. Journal of Academy of Sciences of the Republic of Tajikistan.  52(5):386-390.Interpretive Summary: Pectin is a plant cell wall polysaccharide. It has been known as a gelling, thickening, and film forming reagent. Million tons of pectin can be extracted from the residues of the U.S. fruit and vegetable processing, such as orange peels or sugar beet pulp. Currently, pectin is mainly used as food additives in food industries. Due to the limited market size, only a small portion of the available pectin is produced. Pectin was also studied for the use as materials for the construction of drug carriers, which deliver drugs from the mouth to the colonic site. The present in vivo study demonstrated the practicability of using pectin for colon-specific drug delivery. The research will, eventually, expand the market for pectin. The U.S. fruit and sugar beet growers will be benefited.
                                Technical Abstract: Pectin-protein complex hydrogel beads were tested in vivo on rats. The beads were pre-loaded with a model drug, piroxicam (PX), in ethanol at different loading rates. The rats were starved 8 hr prior to experiment. The rats were then fed with the beads. Blood samples were taken in 2, 4, 6, 12, and 24 hr post feeding. As blood plasma evaluation revealed, the pectin/protein beads are non-toxic and biocompatible. The beads were able to deliver the model drug at the colonic site of the rats; and the drug remained in the body for a prolonged time.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov