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Title:   Author  item
                                            DEEGAN, KATHLEEN - California State Universityitem
                                            RAMIREZ-ZEA, MANUEL - Instituto Biologicio - Brazilitem
                                            ZULETA, CLARA - Instituto Biologicio - Brazilitem
                                            LILDBALLE, DORTE - Aarhus Universityitem
                                            NEXO, EBBA - Aarhus Universityitem
                                            Allen, Lindsay

                                                         - *A*
  Submitted to: European Journal of Clinical Nutrition
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/11/2010
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: High dose vitamin B-12 supplements (=750 μg/day) did improve maternal status and increase milk B-12 concentration in a sample of women, this is not an effective or efficient method for improving infant vitamin B-12 status. Given the potential adverse effects of vitamin B-12 deficiency on infant development there is need for a more effective approach. Since maternal vitamin B-12 status is also of concern, and both maternal and infant vitamin B-12 deficiency and depletion are common in populations consuming low intakes of ASF, policies such as vitamin B-12 fortification of flour, or maternal supplementation prior to conception and during pregnancy, should be evaluated for their effectiveness.
                                Technical Abstract: Vitamin B-12 deficiency is common in mothers and infants where maternal intake of animals source foods is low. The first six months post-partum is a critical period of neurological development requiring vitamin B-12. A pilot study was designed to determine the dose of B-12 to the mothers that would normalize infant B-12 status in vitamin B-12 depleted lactating women and their infants in Guatemala. Women were screened for marginal serum B-12 status (150-220 pmol/L), then randomized to one of six doses (rang 3 to 1000 μg/d) for two months. After one month, a dose response was observed in maternal serum B-12 (r=0.77, P<0.001) and milk B-12 (r=0.78, P<0.001), but not in infant serum B-12 (r=0.15, P<0.001) or infant UMMA (r=-0.13, P<0.33). After 2 months the significant dose response in maternal serum and milk B-12 concentrations persisted, but no supplementation level produced normal B-12 status in all infants (serum B-12 <250 pmol/L).


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