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Title:   Author  item
                                            McCormick, Susan
  Submitted to: American Chemical Society Symposium Series
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 12/18/2008
                                    Publication  Date: 12/20/2009
                                    Citation: McCormick, S.P. 2009. Phytotoxicity of Trichothecenes. In Appell, M., Kendra, D.F., Trucksess, M.W., editors. American Chemical Society Symposium Series 1031. Mycotoxin Prevention and Control in Agriculture. Washington DC: American Chemical Society. p. 143-155.Interpretive Summary:
                                Technical Abstract: Many plant pathogenic species of the genus Fusarium produce trichothecenes that inhibit eukaryotic protein synthesis  Although some Fusarium trichothecenes are virulence factors in plant disease, the phytotoxicities of many trichothecenes have only recently been investigated.  Two test systems have been used to evaluate the structural features of trichothecenes that may impact phytotoxicity.  Detached leaves of Arabidopsis thaliana plants and cultures of the unicellular plant Chlamydomonas reinhardtii were both treated with solutions of trichothecenes from a library of natural and synthetically modified trichothecenes.  Results of these studies suggest that trichothecenes with a C-3 acetoxy group are generally less phytotoxic than those with a C-3 hydroxyl group but that other structural features may be important.  Isotrichodermol, the earliest trichothecene precursor of the mycotoxins T-2 toxin and deoxynivalenol, was toxic in both assays.


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