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Title:   Author  item
                                            PAULINO, GABRIEL - UCD, VET.MED., ANATOMYitem
                                            BARBIER DE LA SERRE, CLAIRE - UCD, VET.MED., ANATOMYitem
                                            Knotts, Trinaitem
                                            Oort, Pieteritem
                                            Newman, Johnitem
                                            Adams, Seanitem
                                            RAYBOULD, HELEN - UCD, VET.MED., ANATOMY
  Submitted to: American Journal of Physiology - Endocrinology and Metabolism
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/30/2009
                                    Publication  Date: 2/3/2009
                                    Citation: Paulino, G., Barbier De La Serre, C., Knotts, T.A., Oort, P.J., Newman, J.W., Adams, S.H., Raybould, H. 2009. INCREASED EXPRESSION OF RECEPTORS FOR OREXIGENIC FACTORS IN NODOSE GANGLION OF DIET-INDUCED OBESE RATS. American Journal of Physiology - Endocrinology and Metabolism, 296:898-903.Interpretive Summary: The vagal afferent pathway is important in short-term regulation of food intake and decreased activation of this neural pathway with long-term ingestion of a high fat diet may contribute to hyperphagic weight gain. We test the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high fat diet, thus supporting orexigenic signals from the gut. Obesity prone (DIO P) rats fed a high fat diet showed increased body weight and hyperleptinemia compared to low fat fed controls and high fat fed diet-induced obese resistant (DIO R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor in the nodose ganglia was increased in DIO P compared with low fat fed or DIO-R rats.  Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
                                Technical Abstract: The vagal afferent pathway is important in short-term regulation of food intake and decreased activation of this neural pathway with long-term ingestion of a high fat diet may contribute to hyperphagic weight gain. We test the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high fat diet, thus supporting orexigenic signals from the gut. Obesity prone (DIO P) rats fed a high fat diet showed increased body weight and hyperleptinemia compared to low fat fed controls and high fat fed diet-induced obese resistant (DIO R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor in the nodose ganglia was increased in DIO P compared with low fat fed or DIO-R rats.  Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.


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