U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Food and Feed Safety Research: College Station, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area College Station, Texas Southern Plains Agricultural Research Center Food and Feed Safety Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            ALALI, WALID - Texas A&M Universityitem
                                            SCOTT, MORGAN - Texas A&M Universityitem
                                            CHRISTIAN, KRISTI - Texas A&M Universityitem
                                            FAJT, VIRGINIA - Texas A&M Universityitem
                                            Harvey, Rogeritem
                                            LAWHORN, BRUCE - Texas A&M University
  Submitted to: Preventive Veterinary Medicine
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/15/2009
                                    Publication  Date: 8/1/2009
                                    Citation: Alali, W.Q., Scott, M.H., Christian, K.L., Fajt, V.R., Harvey, R.B., Lawhorn, B.D. 2009. Relationship between level of antibiotic use and resistance among Escherichia coli isolates from integrated multi-site cohorts of humans and swine. Preventive Veterinary Medicine. 90:160-167.Interpretive Summary: Increased bacterial resistance to antibiotics has become more prevalent worldwide and is of concern to the medical community.  Before antibiotic resistance can be reduced, we need to know what influences antibiotic resistance.  In the present study, we tracked antibiotic usage in humans and swine and examined the member of antibiotic resistant E. coli bacteria that were isolated from each population and compared that to the history of antibiotic usage.  No consistent patterns were observed.  This is important because it shows that while antibiotic usage can be a factor in antibiotic resistance, it is not the only factor.
                                Technical Abstract: The objective of this longitudinal ecological study was to examine the relationship between the prevalence of antibiotic-resistant (AR) commensal E. coli isolates from both monthly human wastewater and composite swine fecal samples, and the concurrent aggregated monthly antibiotic use recorded within each host species in multi-site vertically integrated swine and human populations.  In addition, human vocation (swine worker versus non-swine worker), swine production group, and season were examined as potential confounding variables.  Human and swine E. coli isolates (N= 2,469 human and 2,310 swine, respectively) were tested for antimicrobial susceptibility using a commercial broth microdilution system.  In the human population, among swine workers the relative odds of tetracycline resistance were significantly increased for tetracycline (class) drug use at the third quartile and above mean monthly dosage (MMD) (OR= 1.8) as compared to the referent category (non-use).  The relative odds of ciprofloxacin resistance were significantly increased for ciprofloxacin use in non-swine workers (OR= 5.5) as compared to the referent (non-use).  The relative odds of tetracycline resistance were significantly increased for chlortetracycline use in medicated feed for the upper tertile of MMD category (OR= 2.9) as compared to the referent category (no use) across all swine production groups.  While high variability among seasonal samples over the 3-year period was observed, no common seasonal trends relating to antibiotic use and prevalence of resistance over the 3-year period were apparent.  The overall effects of concurrent human and swine antibiotic use on AR E. coli levels were inconsistent and modest in this study.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov