U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Lager, Kellyitem
                                            Baker, Amyitem
                                            CIACCI-ZANELLA, JANICE - Labex - Embrapaitem
                                            ZANELLA, ERALDO - Universidad De Passo Fundoitem
                                            Miller, Lauraitem
                                            Kehrli Jr, Marcus
  Submitted to: Meeting Abstract
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 9/19/2010
                                    Publication  Date: 10/18/2010
                                    Citation: Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Miller, L.C., Kehrli, Jr., M.E. 2010. Pathogenesis studies of the 2009 pandemic influenza virus and pseudorabies virus from wild pigs in swine. In: Proceedings of the Brazilian Society for Virology XXI Meeting, October 18-20, 2010, Gramado, Rio Grande do Sul, Brazil. p. 33-34.Interpretive Summary:
                                Technical Abstract: Over the last ten years in the United States the epidemiology and ecology of swine flu and pseudorabies has been dynamic. Swine flu is caused by influenza A virus and the disease was first recognized in pigs concurrent with the 1918 Spanish flu pandemic in humans. Pigs displayed clinical signs similar to people affected by the Spanish flu. Reverse genetics has been used to demonstrate that during the 1918 Spanish flu pandemic, pigs and people were infected with a similar virus, an H1N1 influenza virus. In contrast to the severity of disease reported in people, experimental infection of swine with the 1918 Spanish flu virus produced minimal respiratory disease while it induced fatal infections in mice and ferrets. Although the 2009 pandemic H1N1 virus was not as pathogenic in people as the historical reports from 1918, the 2009 virus induced fatal disease in mice and ferrets and induced moderate disease in pigs. Understanding how influenza viruses cause disease and why there are species differences is the subject of intense research by many around the world. Pseudorabies virus (PRV) infection can induce respiratory disease, reproductive failure, and affect the central nervous system. PRV vaccines have been used to eradicate the virus from swine herds and even from entire countries. One weakness in PRV control and eradication programs is the indigenous PRV infection of feral swine. Since the eradication of PRV from the U.S. commercial swine herd, there have been rare case reports of commercial swine becoming infected with feral swine PRV isolates. The difficulty in controlling the expansion of the feral swine population in North America presents a chronic threat to the PRV-free status of the US commercial swine herd. A better understanding of this source of infection may lead to improved PRV control programs. This report summarizes studies investigating the pathogenicity and transmissibility of influenza viruses and feral swine PRV isolates from the U.S. in swine.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov