UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



FORM 10-Q



(Mark One)



[X]      QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2008





[  ]   TRANSITION REPORT UNDER
SECTION 13 OR 15(d) OF THE EXCHANGE ACT OF 1934

For the transition period from _________ to __________



Commission File Number: 000-51074





BIOFORCE NANOSCIENCES HOLDINGS, INC.

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(Exact name of small business issuer as specified in its charter)





|                                                               |  |                                                       
|-------------------------------------------------------------- |  | ------------------------------------------------------
|Nevada                                                         |  | 38-3718471                                            
|---------------------------------------------------------      |  | ------------------------------------------------------
|(State or other jurisdiction of
incorporation or organization) |  | (I.R.S. Employer Identification Number)               





1615 Golden Aspen Drive, Suite 101, Ames, Iowa 50010

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(Address of principal executive offices)



(515) 233-8333

----------------------------------

(Registrant's telephone number)



Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Exchange Act during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.                                                                                      Yes [ X ]   No [   ]



Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company.  See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange Act.



Large accelerated filer  [  ]

Accelerated filer  [  ]



Non-accelerated filer  [  ]

Smaller reporting company  [X]



Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes [   ]    No [ X ]





State the number of shares outstanding of each of the issuer's classes of common equity, as of the latest practicable date: 25,260,845 shares of Common Stock, $0.001 par value, as of November 11, 2008.









BioForce Nanosciences Holdings, Inc.



TABLE OF CONTENTS



Page

PART I  FINANCIAL INFORMATION



Item 1.

Financial Statements

3



Item 2.

Managements Discussion and Analysis or Plan of Operation

14



Item 3.

Quantitative and Qualitative Disclosures about Market Risk

20



Item 4.

Controls and Procedures

20



Item 4A(T).

Controls and Procedures

22



PART II  OTHER INFORMATION



Item 1.

Legal Proceedings

22



Item 1A.

Risk Factors

22



Item 2.

Unregistered Sales of Equity Securities and Use of Proceeds

22



Item 3.

Defaults Upon Senior Securities

22



Item 4.

Submission of Matters to a Vote of Security Holders

23



Item 5.

Other Information

23



Item 6.

Exhibits

23





2









BioForce Nanosciences Holdings, Inc.

Report on Form 10-Q

For the Quarter Ended September 30, 2008





PART I  FINANCIAL INFORMATION





Item 1.  Financial Statements.



The accompanying balance sheets of BioForce Nanosciences Holdings, Inc. at September 30, 2008 and December 31, 2007, and the related statements of operations, stockholders' equity and cash flows for the three and nine month periods ended September 30, 2008 and 2007, have been prepared by our management in conformity with United States generally accepted accounting principles. In the opinion of management, all adjustments considered necessary for a fair presentation of the results of operations and financial position have been included and all such adjustments are of a normal recurring nature. Operating results for the three and nine month periods ended September 30, 2008 are not necessarily indicative of the results that can be expected for the fiscal year ending December 31, 2008.





BIOFORCE NANOSCIENCES HOLDINGS, INC.CONSOLIDATED BALANCE SHEETSASSETS09/30/0812/31/07(unaudited)CURRENT ASSETSCash and cash equivalents$       12,177$      268,930Accounts receivable - trade, net269,092313,756Inventory769,3181,046,683Prepaid expenses and other assets76,556146,007Total current assets1,127,1431,775,376PROPERTY AND EQUIPMENTComputer equipment79,774113,963Leasehold improvements380,000380,000Scientific and laboratory equipment663,978889,368Office furniture and fixtures78,53489,760Total1,202,2861,473,091Less accumulated depreciation827,325889,469Net property and equipment374,961583,622INTANGIBLE ASSETSPatent costs, net of accumulated amortization of $102,576 and $78,502, respectively571,714641,017Trademark costs, net of accumulated amortization of $21,885 and $15,471, respectively103,09590,908Total intangible assets674,809731,925OTHER ASSETSLong-term receivables20,500-Investment in Aspera Corp.23-Total other assets20,523-TOTAL ASSETS$   2,197,436$   3,090,923The accompanying notes are an integral part of these consolidated financial statements.3BIOFORCE NANOSCIENCES HOLDINGS, INC.CONSOLIDATED BALANCE SHEETSLIABILITIES AND STOCKHOLDERS' EQUITY09/30/0812/31/07(unaudited)CURRENT LIABILITIESAccounts payable$      505,711$      305,314Accrued expenses320,868241,650Note payable - accounts receivable factoring150,605-Accrued dividends on preferred stock10,00013,333Deferred revenue32,39653,7548% convertible secured promissory notes488,142-Current portion of long-term notes payable80,02389,180Total current liabilities1,587,745703,231LONG-TERM DEBT, NET115,160154,860Total liabilities1,702,905858,091COMMITMENTS and CONTINGENCIESSTOCKHOLDERS' EQUITYPreferred stock - 2008 and 2007: $0.001 par value, 10,000,000 shares authorizedto be issued in various classesSeries A Convertible Preferred Stock -2008 and 2007: $0.001 par value  1,100,000shares authorized, 1,000,000 shares issued and outstanding, 2008: liquidationvalue $510,000; 2007: liquidation value $513,3331,0001,000Common stock - 2008 and 2007: $0.001 par value, 100,000,000 shares authorized,2008: 25,160,845 shares issued and outstanding; 2007: 25,099,950 sharesissued and outstanding25,16125,100Additional paid-in capital16,999,32116,341,714Deferred stock offering costs(25,000)-Accumulated deficit(16,505,951)(14,134,982)Total stockholders' equity494,5312,232,832TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY$ 2,197,436$ 3,090,923


The accompanying notes are an integral part of these consolidated financial statements.



4



BIOFORCE NANOSCIENCES HOLDINGS, INC.CONSOLIDATED STATEMENTS OF OPERATIONS(unaudited)For the Three Months EndedFor the Nine Months EndedSeptember 30,September 30,2008200720082007REVENUES$       240,865$           35,842$      856,155$      579,408COST OF GOODS SOLD137,16095,557512,793433,918Gross margin103,705(59,715)343,362145,490OPERATING EXPENSESResearch and development294,034326,354898,833897,202Sales and marketing221,212289,610806,218919,015General and administrative334,962628,6541,130,6581,960,875Reimbursement of grant expenses(101,934)(125,195)(267,181)(415,415)Total operating expenses748,2741,119,4232,568,5283,361,677Loss from operations before other income (expense)(644,569)(1,179,138)(2,225,166)(3,216,187)OTHER INCOME (EXPENSE)Interest and other income2646,2628,29241,236Debt forgiveness income-164,250-164,250Abandoned stock offering costs-(256,500)-(256,500)Gain on equipment sale44,434-44,434-Interest expense(59,774)(3,719)(118,088)(10,519)Total other income (expense)(15,076)(89,707)(65,362)(61,533)Loss before income tax(659,645)(1,268,845)(2,290,528)(3,277,720)INCOME TAX EXPENSE----Net loss$     (659,645)$     (1,268,845)$  (2,290,528)$  (3,277,720)DIVIDENDS ON PREFERRED STOCK10,000134,44430,000134,444Net loss on common stock$     (669,645)$     (1,403,289)$  (2,320,528)$  (3,412,164)BASIC AND DILUTED LOSS PER SHARE($0.03)($0.06)($0.09)($0.14)WEIGHTED AVERAGE NUMBER OF SHARES OUTSTANDING25,154,08224,099,95025,128,27224,083,466




The accompanying notes are an integral part of these consolidated financial statements.



5

BIOFORCE NANOSCIENCES HOLDINGS, INC.CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITYFor the period January 1, 2007 through September 30, 2008 (unaudited)AdditionalDeferredTotalPreferred StockCommon StockPaid-InStock OfferingAccumulatedStockholders'SharesAmountSharesAmountCapitalCosts(Deficit)EquityBalance at January 1, 2007-$               -23,999,950$         24,000$   13,824,501$               -$   (9,906,603)$     3,941,898Net loss for the year------(3,854,206)(3,854,206)Dividends on preferred stock------(13,333)(13,333)Dividends related to sale of warrants----218,546-(218,546)-Preferred stock conversion discount----142,294-(142,294)-Issuance of common stockfor services--100,000100256,400--256,500Issuance of Series A ConvertiblePreferred Stock for cash,net of issuance costs of $130,6961,000,0001,000--65,474--66,474Issuance of stock purchase warrantsfor cash, net of issuance costsof $200,733----102,097--102,097Issuance of common stock uponexercise of stock purchase warrants,net of issuance costs of $45,000--1,000,0001,000454,000--455,000Stock-based compensation expense -options and warrants----1,278,402--1,278,402Balance at December 31, 20071,000,0001,00025,099,95025,10016,341,714-(14,134,982)2,232,832Net loss for the nine months endedSeptember 30, 2008------(2,290,528)(2,290,528)Dividends on preferred stock------(30,000)(30,000)Issuance of common stock inpayment of preferred stock dividends--60,8956133,272--33,333Deferred stock offering costs-----(25,000)-(25,000)Stock-based compensation expense -options and warrants----405,820--405,820Issuance of stock purchase warrantsfor cash, net of issuance costsof $4,931----139,037--139,037Dividends related to sale of warrants----50,441-(50,441)-Intrinsic value of beneficial conversionfeature of 8% convertible secured notes----29,037--29,037Balance at September 30, 2008 (unaudited)1,000,000$           1,00025,160,845$         25,161$   16,999,321$        (25,000)$  (16,505,951)$       494,531The accompanying notes are an integral part of these consolidated financial statements.6






BIOFORCE NANOSCIENCES HOLDINGS, INC.CONSOLIDATED STATEMENTS OF CASH FLOWS(unaudited)For the Nine Months EndedSeptember 302008
    2007CASH FLOWS FROM OPERATING ACTIVITIESNet loss
    
    $  (2,290,528)
    $  (3,277,720)Adjustments to reconcile net loss to netcash used by operating activities:Depreciation and amortization
    191,949
    185,267Stock-based compensation expense
    405,820
    863,729Patent/trademark abandonment
    124,515
    -Interest expense due to intrinsic value of beneficial conversion optionon 8% convertible secured promissory notes
    29,037
    -Interest expense due to amortization of issuance discount on8% convertible secured promissory notes
    47,179
    -Gain on sale of property and equipment
    44,434
    -Abandoned stock offering costs
    -
    256,500Debt forgiveness income
    -
    (164,250)Change in:(Increase) Decrease in accounts receivable
    44,664
    15,778(Increase) Decrease in inventory
    277,365
    64,519(Increase) Decrease in prepaid expenses and other assets
    69,451
    (47,045)(Increase) Decrease in long-term receivables
    (20,500)
    -Increase (Decrease) in accounts payable
    200,397
    (187,890)Increase (Decrease) in accrued expenses
    79,218
    228,819Increase (Decrease) in accrued dividends on preferred stock
    30,000
    -Increase (Decrease) in deferred revenue
    (21,358)
    33,464Net cash used by operating activities
    (788,357)
    (2,028,829)CASH FLOWS FROM INVESTING ACTIVITIESAcquisition of property and equipment
    (27,674)
    (257,659)Patent and trademark costs
    (98,760)
    (143,095)Investment in Aspera Corp.
    (23)
    -Net cash used by investing activities
    (126,457)
    (400,754)CASH FLOWS FROM FINANCING ACTIVITIESPayments made on long-term debt
    (48,857)
    (46,909)Proceeds from issuance of 8% convertible secured promissory notes, net ofissuance costs
    440,963
    -Proceeds from accounts receivable financing
    492,313
    -Payments made on accounts receivable financing
    (341,708)
    -Proceeds from issuance of warrants, net of issuance costs
    139,037
    229,729Proceeds from issuance of preferred stock, net of issuance costs
    -
    131,111Dividends on preferred stock
    (30,000)
    (3,333)Deferred stock offering costs
    (25,000)
    -Proceeds from sale/leaseback of equipment
    31,313
    -Proceeds from issuance of long-term debt
    -
    68,201Net cash provided by financing activities
    658,061
    378,799Net (decrease) increase in cash
    (256,753)
    (2,050,784)CASH AND CASH EQUIVALENTS - beginning of period
    268,930
    2,602,686CASH AND CASH EQUIVALENTS - end of period
    $         12,177
    $      551,902SUPPLEMENTAL DISCLOSURESCash paid for interest
    $         70,909
    $         3,116Cash paid for income taxes
    $                 -
    $                -Non-cash financing activities:Common stock issued in payment of preferred stock dividend
    $         33,333
    $                -Common stock issued for financing services
    $                 -
    $      256,500Warrants issued for financing services
    $                 -
    $      192,269The accompanying notes are an integral part of these consolidated financial statements.7










BioForce Nanosciences Holdings, Inc.

Notes to Financial Statements





Note 1  Basis of Financial Statement Presentation



The accompanying unaudited financial statements have been prepared by us pursuant to the rules and regulations of the Securities and Exchange Commission.  Certain information and footnote disclosures normally included in financial statements prepared in accordance with accounting principles generally accepted in the United States of America have been condensed or omitted in accordance with such rules and regulations.  The information furnished in the interim financial statements includes normal recurring adjustments and reflects all adjustments which, in our opinion, are necessary for a fair presentation of such financial statements.  Although we believe the disclosures and information presented are adequate to make the information not misleading, it is suggested that these interim condensed financial statements be read in conjunction with our most recent audited financial statements and notes thereto included in our Annual Report for the year ended December 31, 2007 on Form 10-KSB.  Operating results for the three and nine month periods ended September 30, 2008 are not necessarily indicative of the results that may be expected for the year ending December 31, 2008.





Note 2  Going Concern



The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America, which contemplate our continuation as a going concern.  Our platform product, the Nano eNablerTM system, was launched in 2005, with initial sales occurring in 2006.  Due to the fact that we are still at an early stage of development of the market for the Nano eNablerTM system and our other products, we have sustained significant operating losses in recent years.  As a result of these losses, we are dependent upon debt and equity financing, and revenues from the sales of our Nano eNablerTM system and other products, to fund our future operations.

Our plans to continue as a going concern are centered upon the achievement of profitable operations.  We are endeavoring to increase prospective customer awareness of our products through our sales and marketing efforts, and will continue to reduce our costs of operations where possible.  It is our intention to augment our revenues by raising a sufficient amount additional capital through debt and/or equity financings to sustain our operations.

Our ability to continue as a going concern is dependent upon our ability to successfully accomplish the plan described in the preceding paragraph. The accompanying financial statements do not include any adjustments that might be necessary if we are unable to continue as a going concern.



Note 3  Summary of Significant Accounting Policies



Business Activity

We have developed our platform product, the Nano eNablerTM benchtop molecular printer, which we started marketing commercially in 2005. Other products include our Cyto eNablerTM molecular printer, consumable printing and surface patterning tools for use with the Nano eNablerTM and Cyto eNablerTM systems, surfaces which have been patterned with biological material, and our ProCleanerTM instrument for sterilization of various scientific laboratory items.  To date, the primary markets for our products have been academic and other research institutions in North America, Europe and Asia.  In April 2007, we discontinued our business activities related to the production and sale of certain products designed for use with atomic force microscopes and scanning probe microscopes.

Consolidation

The consolidated financial statements include the accounts of the Company and our wholly-owned subsidiary, BioForce Nanosciences, Inc.  All intercompany accounts and transactions have been eliminated.

Cash and Cash Equivalents

For the purposes of the statement of cash flows, we consider all investments with original maturities of three months or less to be cash equivalents.

Accounts Receivable

Accounts receivable are uncollateralized customer obligations due under normal trade terms, typically requiring payment within thirty days from the invoice date, and are stated at the amount billed.  Payments of accounts receivable are allocated to the specific invoices identified on the customers remittance advice or, if unspecified, are applied to the earliest unpaid invoices. We periodically review accounts receivable balances for uncollectible amounts.



8









Inventories

Inventories are valued primarily at the lower of cost or market. Cost is determined using the first-in, first-out method. Market is determined based on the net realizable value. We estimate and record provisions for obsolete inventories when necessary.

Property and Equipment

Property and equipment are recorded at cost.  Depreciation is computed using the straight-line method over the estimated useful lives of the assets (usually 5 to 7 years). Leasehold improvements are being amortized over a period of five years.  The leasehold improvements will be fully amortized in April 2010.  The leased property is being occupied pursuant to a month to month lease, which may be cancelled by either us or the landlord on ninety days notice.  Expenditures for maintenance and repairs are expensed when incurred and betterments are capitalized. We assess the carrying values of long-lived assets for impairment when circumstances warrant such a review.  In performing this assessment, we consider current market analysis and appraisal of the property and equipment, along with estimates of future cash flows.  We recognize impairment losses when undiscounted cash flows estimated to be generated from long-lived assets are less than the amount of undepreciated assets.

Intangible Assets

Intangible assets consist of patent and trademark costs.  Patent costs are costs incurred to develop and file patent applications.  Trademark costs are costs incurred to develop and file trademark applications. If the patents or trademarks are approved, the costs are amortized using the straight-line method over the estimated lives of 7 years for patents and 10 years for trademarks. In cases where we discontinue maintenance of an issued patent or trademark, any unamortized costs associated with the abandoned patent or trademark are expensed at the time of abandonment.  Unsuccessful patent and trademark application costs are expensed at the time the application is denied.  We assess the carrying values of long-lived assets for impairment when circumstances warrant such a review. In performing this assessment, we consider current market analysis and appraisal of the technology, along with estimates of future cash flows.  We recognize impairment losses when undiscounted cash flows estimated to be generated from long-lived assets are less than the amount of unamortized assets.

Beneficial Conversion Feature

We have adopted Emerging Issues Task Force (EITF) Issue No. 98-5, Accounting for Convertible Securities with Beneficial Conversion Features or Contingently Adjustable Conversion Ratios, and EITF Issue No. 00-27, Application of EITF Issue No. 98-5 to Certain Convertible Instruments. We have incurred debt with conversion features that provide for rates of conversion below market value.  We have also issued shares of our Series A Convertible Preferred Stock that provided for a rate of conversion to Common Stock that was below the market value of our Common Stock on the date of issuance.  These features were recorded as beneficial conversion features pursuant to EITF Issues No. 98-5 and 00-27.

Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires us to make estimates and assumptions that affect certain reported amounts and disclosures. Accordingly, actual results could differ from those estimates.

Research and Development Costs

In accordance with Statement of Financial Accounting Standards No. 2, Accounting for Research and Development Costs, research and development costs are expensed as incurred. Research and develpoment cost for the nine month periods ended September 30, 2008 and 2007 were $898,833 and $897,202, respectively.

Revenue Recognition

We apply the provisions of SEC Staff Accounting Bulletin No. 104, Revenue Recognition in Financial Statements (SAB 104), which provides guidance on the recognition, presentation and disclosure of revenue in financial statements filed with the SEC.  SAB 104 outlines the basic criteria that must be met to recognize revenue and provides guidance for disclosure related to revenue recognition policies.  In general, we recognize revenue related to goods and services provided when (i) persuasive evidence of an arrangement exists, (ii) delivery has occurred or services have been rendered, (iii) the fee is fixed or determinable, and (iv) collectability is reasonably assured.



9









Our revenues are generated from sale of products, performance of professional services and provision of warranty services.  Revenues from the sale of products are generally recognized upon shipment of product, which corresponds with the transfer of title. The costs of shipping are typically billed to the customer upon shipment and are included in cost of sales.  Revenues from the provision of professional services are recognized at such time as the services are provided.  Warranty services revenues are recognized ratably over the term of the warranty period.

Stock Options and Warrants

Prior to January 1, 2006, we accounted for employee stock-based  compensation under the recognition and measurement provisions of Accounting Principles Board Opinion No. 25, Accounting for Stock Issued to Employees, and related interpretations (APB 25), as permitted by FASB Statement No. 123, Accounting for Stock-Based Compensation (SFAS 123).  No stock-based employee compensation cost was recognized for option or warrant awards in our consolidated statements of operations for the periods prior to January 1, 2006, as all such awards had an exercise price equal to the market value of the Common Stock on the date of the grant in accordance with APB 25.



Effective January 1, 2006, we adopted the fair value recognition provisions of FASB Statement No. 123(R), Share-Based Payment (SFAS 123R), using the modified-prospective-transition method, for employee stock-based compensation.  Under this transition method, total compensation cost recognized in 2007 and 2006 includes compensation costs for all share-based payments granted prior to, but not yet vested as of January 1, 2006, based on the grant date fair value estimated in accordance with the original provisions of SFAS 123, and compensation costs for all share-based payments granted subsequent to January 1, 2006, based on the grant date fair value estimated in accordance with the provisions of SFAS 123R.  We estimated the fair value of our employee option and warrant awards granted prior to January 1, 2006 using the Black-Scholes option-pricing formula, and continue to use this model.  We record compensation expense for employee stock options and warrants ratably over the vesting period.  Results for prior periods have not been restated.



We account for non-employee stock-based compensation, including issuance of warrants, in accordance with Emerging Issues Task Force (EITF) 96-18 Accounting for Equity Instruments That Are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods and Services.  Amounts are based upon the fair value of the consideration received or the fair value of the equity instruments issued, whichever is more reliably measurable.  We estimate the fair value of stock purchase warrants using the Black-Scholes option-pricing formula.



Basic and Fully Diluted Loss Per Share of Common Stock



The basic loss per share of Common Stock is based on the weighted average number of shares issued and outstanding during the period of the financial statements.  Outstanding stock options, stock purchase warrants, Series A Convertible Preferred Stock which is convertible into shares of our Common Stock, and 8% convertible secured promissory notes which are convertible into shares of our Common Stock, have not been considered in the fully diluted loss per share calculations due to their anti-dilutive effect.



Impairment of Long-Lived Assets



In accordance with Financial Accounting Standards Board Statement No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets,we record impairment of long-lived assets to be held and used or to be disposed of when indicators of impairment are present and the undiscounted cash flows estimated to be generated by those assets are less than the carrying amount.



Fair Value of Financial Instruments



The recorded amounts of financial instruments, including cash equivalents, accounts receivable, accounts payable, accrued expenses, and long-term debt, approximate their market values. We have no investments in derivative financial instruments.





Note 4 - Inventories



Inventories consisted of the following at September 30, 2008 and December 31, 2007:



September 30,

December 31,

2008

2007

(unaudited)



Component parts and raw materials

$308,012

$465,254

Finished goods

299,377

258,259

Units placed at prospective customer sites

161,929

323,170

-------------

-------------

Total inventories

$769,318

$1,046,683

========

========



10





Note 5  Accounts Receivable Factoring Facility



In March 2008 we entered into an accounts receivable factoring agreement with a finance company.  Under the terms of this agreement we are able to receive advances of 80% of eligible domestic customer invoices, with the balance of the invoice less financing costs paid to us at the time that the customer pays the invoice.  Eligibility is based upon the finance companys approval of the customers credit. In addition, the finance company has the right to reject any customer invoice for any reason.  Ownership of the financed invoices is transferred to the finance company under this agreement.  We are obligated to immediately repurchase any customer invoice that remains unpaid sixty days after purchase by the finance company.  Because we have a recourse obligation under this agreement, the factored customer invoices remain recorded on our financial statements until paid by the customer, and the proceeds from the sale of the invoice to the finance company are recorded as a liability until the customer has paid the invoice amount or we have repurchased the invoice.  Our costs of utilizing this facility are 3.00% - 4.00% of the face amount of the customer invoice, depending upon the length of time that the advance is outstanding.





Note 6  8% Convertible Secured Promissory Notes and Warrants



In June 2008 and July 2008 we completed private placements of securities from which we received gross proceeds of $600,000, and net proceeds after transaction costs of $580,000.  The securities issued in these placements were $600,000 in face value of our 8% convertible secured promissory notes, and warrants to purchase a total of 1,800,000 shares of our Common Stock.



In accordance with EITF 00-27, a portion of the net proceeds from these offerings were allocated to the warrants based on their relative fair values, which totaled $189,479 using the Black Scholes option pricing model.  The difference between the effective conversion prices of the 8% convertible secured promissory notes, based upon the $440,963 of net proceeds from the transaction which were allocated to the notes, and the fair values of our Common Stock on the dates that the notes were issued, were recorded as beneficial conversion options in accordance with EITF 00-27.  The beneficial conversion options, in the amount of $29,037, were recorded as interest expense and increases to additional paid in capital. The $159,037 difference between the face values of the 8% convertible secured promissory notes and the portions of the proceeds allocated to the 8% convertible secured promissory notes is being amortized, and recorded as interest expense, over the twelve month term of the notes.  The differences between the fair values of the warrants and the portions of the net proceeds allocated to the warrants were recorded as dividends in the amount of $50,441.  These dividends were recorded as a reduction of retained earnings and an increase to additional paid in capital.



The notes are convertible into shares of our Common Stock at a rate of one share of Common Stock for each $0.30 in face value of the notes.  This conversion price per share is subject to adjustment if we issue Common Stock, or securities convertible into Common Stock, for a price of less than $0.30 per share.  The holders of the notes have the right to convert the notes into any securities offering that we conduct while the notes are outstanding, on the terms of that offering.  If we conduct one or a series of securities offerings which raises at least $1,000,000 in gross proceeds while the notes are outstanding, we have the ability to require that the holders convert the notes on the terms of that subsequent offering, or into shares of Common Stock at the conversion price per share, with the holders having the option as to which of the conversion options will be used.   The notes are secured by all of our assets.





Note 7  Long-Term Debt



We received $100,000 during 2003 under a Community Economic Betterment Account (CEBA) venture project royalty agreement with the Iowa Department of Economic Development.  The agreement requires us to pay an annual royalty equal to one percent of prior year total gross revenues, paid in equal semi-annual payments, until a total repayment of $200,000 has been reached.  The estimated total repayment for 2008 is $11,000.  As of September 30, 2008, we were $5,500 in arrears on scheduled payments on this loan.



11













We received a $100,000 non-interest bearing loan from the State of Iowa during 2005.  This loan is repayable in monthly installments of $1,667, and is secured by three specific pieces of our scientific and laboratory equipment.  As of September 30, 2008, we were $6,668 in arrears on scheduled payments on this loan.



We received loans totaling $100,000 from the City of Ames, Iowa during 2005. These loans are repayable in monthly installments totaling $1,099, which include interest at an annual rate of 2.125%.   As of September 30, 2008, we were $8,791 in arrears on scheduled payments on these loans.



We received a $68,201 loan from a finance company during 2007.  This loan was repayable in monthly installments of $5,484, which included interest at an annual rate of 7.67%.



We had the following debt obligations at September 30, 2008 and December 31, 2007:



September 30,

December 31,



2008

2007

(unaudited)

Note payable, CEBA, due semi-annually, non-interest

bearing and unsecured, payments based upon revenues

$92,254

$92,254



Note payable, State of Iowa, payable in monthly

installments, non-interest bearing, secured by certain

scientific and laboratory equipment

58,333

66,667



Notes payable, City of Ames, Iowa, payable in monthly

installments including interest at 2.125%, unsecured

44,596

52,939



Note payable, finance company, payable in monthly

installments including interest at 7.67%, unsecured

-

32,180

------------

-------------

Total long-term debt obligations

$195,183

$244,040

Less current portion

(80,023)

(89,180)

-----------

------------

Long-term portion

$115,160

$154,860

=======

=======



Note 8 Stock Warrants and Options



Warrants



At September 30, 2008, we had outstanding warrants that allow the holders to purchase up to 4,454,464 shares of our Common Stock at prices ranging from $0.15 to $3.90 per share, and 100,000 shares of our Series A Convertible Preferred Stock at a price of $0.50 per share.



Issuances of Common Stock warrants during the nine months ended September 30, 2008 consisted of the following:





Exercise

Contractual

Number

Price

Life

Issued To

Other Conditions

900,000

$0.30

5 years

Investors

- Immediately vested

- Exercise price adjusted for future Common Stock

issuances at a price per share below exercise price

- Cashless exercise available if no registration statement

covering warrant shares effective on exercise date if

after June 10, 2009



12







- $98,173 fair value used in allocation of proceeds from

financing between warrants and convertible notes issued



900,000

$0.30

5 years

Investor

- Immediately vested

- Exercise price adjusted for future Common Stock

issuances at a price per share below exercise price

- Cashless exercise available if no registration statement

covering warrant shares effective on exercise date if

after July 21, 2009

- $91,306 fair value used in allocation of proceeds from

financing between warrants and convertible notes issued



50,000

$0.32

5 years

Consultants

- Immediately vested

- $8,221 fair value recorded as general and administrative

cost on date of issuance



100,000

$0.20

5 years

Employee

- Immediately vested

- $10,160 fair value recorded as research and development

cost on date of issuance



19,514

$0.15

5 years

Employees

- Immediately vested

- $1,483 fair value recorded as operating expense on date of

Issuance



A summary of our outstanding Common Stock warrants as of September 30, 2008, and the changes during 2007 and 2008, are presented below:





Weighted

Number of

Average

Shares

Exercise Price



Outstanding at January 1, 2007

1,264,428

$1.28

Warrants issued-2007

4,480,000

$0.75

Warrants exercised-2007

(1,000,000)

-

------------

----------

Outstanding at January 1, 2008

4,744,428

$0.95

Warrants issued-2008

1,969,514

$0.29

Warrants exercised-2008

-

-

Warrants expired or otherwise no longer exercisable-2008

(2,259,478)

$0.82

------------

----------

Outstanding at September 30, 2008

4,454,464

$0.72

=========

==========

Exercisable at September 30, 2008

4,454,464

$0.72

=========

==========



13



Options



During the second quarter of 2007 our Board of Directors approved the BioForce Nanosciences Holdings, Inc. Amended and Restated 2006 Equity Incentive Plan.  Under the terms of this plan, options may be granted to officers, directors, employees, consultants and independent contractors to purchase up to an aggregate of 7,197,245 shares of our Common Stock.  This plan, which was approved by our shareholders on May 8, 2008, replaced the BioForce Nanosciences Holdings, Inc. 2006 Equity Incentive Plan, the BioForce Nanosciences, Inc. 2003 Stock Option Plan and the BioForce Nanosciences, Inc. 2000 Amended and Restated Stock Option Plan.  As of September 30, 2008, there were 4,039,700 options outstanding under this plan at exercise prices of $0.18 to $4.60 per share.

A summary of our outstanding Common Stock options as of September 30, 2008, and the changes during 2007 and 2008, are presented below:





Weighted

Number of

Average

Shares

Exercise Price



Outstanding at January 1, 2007

2,433,497

$1.82

Options issued-2007

2,532,460

$1.40

Options exercised- 2007

-

-

Options canceled-2007

(293,447)

$1.84

-----------

----------

Outstanding at January 1, 2008

4,672,510

$1.40

Options issued-2008

135,000

$0.35

Options exercised-2008

-

-

Options canceled-2008

(767,810)

$1.80

-----------

----------

Outstanding at September 30, 2008

4,039,700

$1.29

=======

=======

Exercisable at September 30, 2008

2,154,236

$1.46

=======

=======



Note 9  Issuances of Common Stock



In January 2008 we issued 16,451 shares of our Common Stock in payment of the $13,333 of accrued dividends on our Series A Convertible Preferred Stock as of December 31, 2007.



In July 2008 we issued 44,444 shares of our Common Stock in payment of the $20,000 of accrued dividends on our Series A Convertible Preferred Stock as of June 30. 2008.





Note 10  Series A Convertible Preferred Stock

The Series A Convertible Preferred Stock calls for a dividend of 8% per year, payable semi-annually.  The dividend may be paid, at our option, in shares of our Common Stock in lieu of cash.  The shares have a liquidation preference of $0.50 per share, plus any accrued and unpaid dividends, which much be paid before any payment shall be made or assets distributed to holders of our Common Stock.  The Series A Convertible Preferred Stock is convertible, at the option of the holder but no later than August 31, 2010, into shares of our Common Stock at the rate of one share of Common Stock for each $0.48 of liquidation preference, subject to adjustment if we issue Common Stock, or securities convertible into Common Stock, for a price lower than $0.48 per share.



Note 11  License of Technology to Aspera Corp.



In August 2008 we completed a transaction whereby we licensed our portfolio of scientific applications technology, on a non-exclusive basis, to Aspera Corp. in exchange for the right to royalties based upon future revenues generated by Aspera Corp. as a result of the licensed technology.  The licensed technology is not related to any of our revenue generating products and services.  As a part of the transaction we acquired a 19% equity interest in Aspera Corp. for $23, transferred to Aspera Corp. four of our employees who were involved in the development of the licensed technology and governmental grants related to the licensed technology which we could not fulfill without the transferred employees, and sold to Aspera Corp. equipment with a book value of $40,115 in exchange for the right to receive up to 1,800 hours of scientific consulting services from Aspera Corp. over a twenty-four month period.  $24,549 of the book value of the sold equipment relates to a Nano eNablerTM system, and $15,566 relates to a variety of other scientific and computer equipment.  The cost of the sold Nano eNablerTM system is included in cost of goods sold, with the allocable portion of the value of the scientific consulting services to be received included in revenues.  The value of the scientific consulting services allocable to the other scientific and computer equipment, less the book value of that equipment, is recorded as a gain on equipment sale.



Note 12  Subsequent Event.



In October 2008 we issued 100,000 shares of Common Stock in payment for investor relations services.





Item 2.  Management's Discussion and Analysis or Plan of Operation.



Forward-Looking and Cautionary Statements



This report contains certain forward-looking statements.  These statements relate to our future financial performance and involve known and unknown risks and uncertainties.  These factors may cause our Companys, or our industrys actual results, levels of activity, performance or achievements to be materially different from those expressed or implied by the forward-looking statements.  In some cases you can identify forward-looking statements by terminology such as may, will, should, expects, intends, plans, anticipates, believes, estimates, predicts, potential, continue, or the negative of those terms or other comparable terminology.



These statements are only predictions.  Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements.



14







Managements discussion and analysis provides a review of our operating results for the three and nine month periods ended September 30, 2008 and 2007, and our financial condition at September 30, 2008.  The focus of this review is on the underlying business reasons for significant changes and trends affecting our revenues, net losses, cash flows and financial condition.  This review should be read in conjunction with the accompanying consolidated financial statements and related notes thereto included in this report.



Results of Operations



Three months ended September 30, 2008 and 2007



Revenues



Our revenues of $240,865 for the three months ended September 30, 2008 represented an increase of $205,023 (572.0%) over revenues of $35,842 for the three month period ended September 30, 2007.  The increase was primarily attributable to there having been three Nano eNablerTM systems sold during the three month period ended September 30, 2008, as compared to no Nano eNablerTM systems having been sold during the three month period ended September 30, 2007.  Additionally, revenues from the sales of our ProCleanerTM instruments during the third quarter of 2008 were more than double the result for the same period in 2007, and our revenues from installation, support and supplies related to our Nano eNablerTM installed base were substantially increased over 2007.



Total revenues for the three month periods ended September 30, 2008 and 2007 were made up of the following components:



2008

2007



Nano eNablerTM system sales

$167,593

$          -

Nano eNablerTM system installation and training services

2,341

-

Nano eNablerTM system warranties

14,656

7,795

SPTTM surface patterning tools and SindexTM silicon chips

10,362

3,308

ProCleanerTM instrument sales

43,723

19,944

Surface patterning services

2,190

-

Other

-

4,795

------------

-----------

Total revenues

$240,865

$35,842

=======

=======



International sales represent a significant portion of our business, with approximately 50% of Nano eNablerTM system sales and 67% of our ProCleanerTM instrument revenues coming from international markets on a historical basis.  Our results for the third quarter of 2008 were consistent with these trends.  The percentage of our business attributable to international customers has not changed significantly during the past three years.



Gross Margins



Overall gross margins were 43.1% during the three months ended September 30, 2008, as compared to a negative 166.6% during the three months ended September 30, 2007.  The gross margin increase from 2007 to 2008 was a result of cost reduction measures instituted subsequent to September 30, 2007, and the substantially higher revenues which were generated during the third quarter of 2008.



Operating Expenses



Effective January 1, 2006, we adopted the fair value recognition provisions of FASB Statement No. 123(R), Share-Based Payment (SFAS 123R), using the modified-prospective-transition method for our employee stock compensation plans.  Our operating expenses for the three months ended September 30, 2008 reflect $99,950 of costs recorded as a result of the implementation of SFAS 123R, as compared to $262,890 for the three months ended September 30, 2007.



Research and development costs for the three month period ended September 30, 2008 were $294,034, as compared to $326,354 for the three month period ended September 30, 2007.  The $32,320 (9.9%) decrease from 2007 to 2008 was primarily a result of our transaction during the third quarter of 2008 with Aspera Corp., which resulted in a number of our research and development personnel being transferred to that company.  Additionally, there was a decrease in the research and development costs recorded as a result of implementation of SFAS 123R.



15









Sales and marketing costs for the three month period ended September 30, 2008 were $221,212, as compared to $289,610 for the three month period ended September 30, 2007.  The $68,398 (23.6%) decrease from 2007 to 2008 was primarily a result of our 2008 shift in domestic sales strategy from direct sales to a lower fixed cost, distributor-based sales model, and a reduction in the sales and marketing costs recorded as a result of implementation of SFAS 123R.



General and administrative costs for the three month period ended September 30, 2008 were $334,962, as compared to $628,654 for the three month period ended September 30, 2007.  The $293,692 (46.7%) decrease from 2007 to 2008 was primarily a result of our Chief Operating Officer being appointed as our Chief Executive Officer in January 2008, elimination of the Chief Operating Officer position as of that same date, elimination of our General Counsel position in September 2007, a reduction in the general and administrative costs recorded as a result of implementation of SFAS 123R, and a reduction in our spending on professional fees related to intellectual property defense and maintenance, offset by a $124,515 charge in the third quarter of 2008 related to the abandonment of certain patent applications and issued patents.



Reimbursement of grant expenses represents amounts that we were reimbursed under grants from the U.S. National Institutes of Health.  Amounts received during the three months ended September 30, 2008 were $101,934, as compared to $125,195 during the three month period ended September 30, 2007.  The decrease from 2007 to 2008 reflects our reduced spending on non-salary costs of grant-related activities, and our transfer of one grant to Aspera Corp. as a part of our transaction with that company in the third quarter of 2008.



Interest and Other Income



Interest and other income for the three months ended September 30, 2008 was $264, as compared to $6,262 for the three months ended September 30, 2007.  The decrease from 2007 to 2008 is a result of lower average cash balances available for investment during 2008.



Gain on Equipment Sale



During the third quarter of 2008 we sold certain equipment to Aspera Corp. as a part of our transaction to license certain technology and transfer certain employees to them.  The equipment had a book value of $40,115, and was sold in exchange for the right for us to receive up to 1,800 hours of scientific consulting services from Aspera Corp. over a twenty-four month period.  The equipment included one Nano eNablerTM system and a variety of other scientific and computer equipment.  The cost of the sold Nano eNablerTM system is included in cost of goods sold, with the allocable portion of the value of the scientific consulting services to be received included in revenues.  The value of the scientific consulting services allocable to the other scientific and computer equipment, less the book value of that equipment, is recorded as a gain on equipment sale.



Interest Expense



Interest expense for the three months ended September 30, 2008 was $59,774, as compared to $3,719 for the three months ended September 30, 2007.  The increase from 2007 to 2008 is a result of costs associated with borrowings on our accounts receivable financing facility which was put into place during 2008, interest on our 8% convertible secured promissory notes which were issued in June and July of 2008, and $39,760 of amortization of the issuance discount on the 8% convertible secured promissory notes.



Debt forgiveness income



Our loan of $150,000 from the State of Iowa, which was forgivable based upon the achievement of certain milestones, was formally forgiven by the State as of a date in the third quarter of 2007.  This resulted in debt forgiveness income of $164,250, representing the principal balance plus $14,250 of interest expense which had been accrued on the loan prior to its forgiveness.



Abandoned stock offering costs



During 2007 we issued 100,000 shares of our Common Stock, valued at $256,500, to an investment bank as a retainer for their services.  In August 2007 we completed a private placement of our Series A Convertible Preferred Stock and warrants to purchase shares of our Common Stock.  This placement was completed without the assistance of the investment bank to which the retainer shares were issued, and we do not anticipate that this investment bank will arrange a future financing for us.  Accordingly, during the third quarter of 2007 we wrote off the costs of issuing the retainer shares, which had been deferred at the time the shares were issued.



16





Net Loss



As a result of the above-mentioned items, our net loss for the three months ended September 30, 2008 was $659,645, as compared to a net loss of $1,268,845 for the three months ended September 30, 2007.



Nine months ended September 30, 2008 and 2007



Revenues



Our revenues of $856,155 for the nine months ended September 30, 2008 represented an increase of $276,747 (47.8%) over revenues of $579,408 for the nine month period ended September 30, 2007.  The increase was primarily attributable to having sold ten Nano eNabler systems during the first nine months of 2008, as compared to four Nano eNabler systems during the first nine months of 2007.  The average selling price of the Nano eNablerTM systems sold during 2008 was lower than that of the systems sold during 2007 due to an increase in the number of sales being made through distributors and to Pilot Placement Program sites.  Additionally, revenues from the sales of our ProCleanerTM instruments during the first nine months of 2008 were significantly higher than they were for the same period in 2007, and our revenues from installation and support related to our Nano eNablerTM installed base were substantially increased over 2007.



Total revenues for the nine month periods ended September 30, 2008 and 2007 were made up of the following components:



2008

2007



Nano eNablerTM system sales

$613,123

$412,315

Nano eNablerTM system installation and training services

16,361

12,082

Nano eNablerTM system warranties

37,963

15,437

SPTTM surface patterning tools and SindexTM silicon chips

20,963

26,313

ProCleanerTM instrument sales

128,784

89,234

Surface patterning services

2,620

-

AFM products

-

14,009

Other

36,341

10,018

------------

-----------

Total revenues

$856,155

$579,408

=======

=======



International sales represent a significant portion of our business, with approximately 50% of Nano eNablerTM system sales and 67% of our ProCleanerTM instrument revenues coming from international markets on a historical basis.  Our results for the first nine months of 2008 were consistent with these trends.  The percentage of our business attributable to international customers has not changed significantly during the past three years.



In April 2007, we discontinued our business activities related to the production and sale of our AFM products.  These activities did not constitute a material portion of our business operations.



Gross Margins



Overall gross margins were 40.1% during the nine months ended September 30, 2008, as compared to 25.1% during the nine months ended June 30, 2007.  The gross margin increase from 2007 to 2008 was a result of cost reduction measures instituted subsequent to September 30, 2007, and increased revenues from sales of our Nano eNablerTM and ProCleanerTM instruments, offset by the lower average selling price of the Nano eNablerTM systems sold during 2008.



Operating Expenses



17







Effective January 1, 2006, we adopted the fair value recognition provisions of FASB Statement No. 123(R), Share-Based Payment (SFAS 123R), using the modified-prospective-transition method for our employee stock compensation plans.  Our operating expenses for the nine months ended September 30, 2008 reflect $396,693 of costs recorded as a result of the implementation of SFAS 123R, as compared to $863,729 for the nine months ended September 30, 2007.



Research and development costs for the nine month period ended September 30, 2008 were $898,833 as compared to $897,202 for the nine month period ended September 30, 2007.  The $1,631 (0.2%) increase from 2007 to 2008 was primarily a result of compensation costs related to our establishment of the Chief Scientific Officer position in January 2008, offset by a decrease in the research and development costs recorded as a result of implementation of SFAS 123R and our transaction during the third quarter of 2008 with Aspera Corp., which resulted in a number of our research and development personnel being transferred to that company.



Sales and marketing costs for the nine month period ended September 30, 2008 were $806,218, as compared to $919,015 for the nine month period ended September 30, 2007.  The $112,797 (12.3%) decrease from 2007 to 2008 was primarily a result of our elimination of the Director of Communications position in August 2007, and our 2008 shift in domestic sales strategy from direct sales to a lower fixed cost, distributor-based sales model.



General and administrative costs for the nine month period ended September 30, 2008 were $1,130,658, as compared to $1,960,875 for the nine month period ended September 30, 2007.  The $830,217 (42.3%) decrease from 2007 to 2008 was primarily a result of our Chief Operating Officer being appointed as our Chief Executive Officer in January 2008, elimination of the Chief Operating Officer position as of that same date, elimination of our General Counsel position in September 2007, a reduction in the general and administrative costs recorded as a result of implementation of SFAS 123R, and a reduction in our spending on professional fees related to intellectual property defense and maintenance.



Reimbursement of grant expenses represents amounts that we were reimbursed under grants from the U.S. National Institutes of Health.  Amounts received during the nine months ended September 30, 2008 were $267,181 as compared to $415,415 during the nine month period ended September 30, 2007.  The decrease from 2007 to 2008 reflects our reduced spending on non-salary costs of grant-related activities, and our transfer of one grant to Aspera Corp. as a part of our transaction with that company in the third quarter of 2008.



Interest and Other Income



Interest and other income for the nine months ended September 30, 2008 was $8,292 as compared to $41,236 for the nine months ended September 30, 2007.  The decrease from 2007 to 2008 is a result of lower average cash balances available for investment during 2008, offset to a degree by a gain on the sale and leaseback of certain equipment during 2008.



Gain on Equipment Sale



During the third quarter of 2008 we sold certain equipment to Aspera Corp. as a part of our transaction to license certain technology and transfer certain employees to them.  The equipment had a book value of $40,115, and was sold in exchange for the right for us to receive up to 1,800 hours of scientific consulting services from Aspera Corp. over a twenty-four month period.  The equipment included one Nano eNablerTM system and a variety of other scientific and computer equipment.  The cost of the sold Nano eNablerTM system is included in cost of goods sold, with the allocable portion of the value of the scientific consulting services to be received included in revenues.  The value of the scientific consulting services allocable to the other scientific and computer equipment, less the book value of that equipment, is recorded as a gain on equipment sale.



Interest Expense



Interest expense for the nine months ended September 30, 2008 was $118,088, as compared to $10,519 for the nine months ended September 30, 2007.  The increase from 2007 to 2008 is a result of costs associated with borrowings on our accounts receivable financing facility which was put into place during 2008, interest on our 8% convertible secured promissory notes which were issued in 2008, $47,179 of amortization of the issuance discount on the 8% convertible secured promissory notes, and $29,037 recorded as interest expense related to the beneficial conversion option on our 8% convertible secured promissory notes issued during 2008.



18







Debt forgiveness income



Our loan of $150,000 from the State of Iowa, which was forgivable based upon the achievement of certain milestones, was formally forgiven by the State as of a date in the third quarter of 2007.  This resulted in debt forgiveness income of $164,250, representing the principal balance plus $14,250 of interest expense which had been accrued on the loan prior to its forgiveness.



Abandoned stock offering costs



During 2007 we issued 100,000 shares of our Common Stock, valued at $256,500, to an investment bank as a retainer for their services.  In August 2007 we completed a private placement of our Series A Convertible Preferred Stock and warrants to purchase shares of our Common Stock.  This placement was completed without the assistance of the investment bank to which the retainer shares were issued, and we do not anticipate that this investment bank will arrange a future financing for us.  Accordingly, during the third quarter of 2007 we wrote off the costs of issuing the retainer shares, which had been deferred at the time the shares were issued.



Net Loss



As a result of the above-mentioned items, our net loss for the nine months ended September 30, 2008 was $2,290,528, as compared to a net loss of $3,277,720 for the nine months ended September 30, 2007.



Forward Looking Statements  Results of Operations



We anticipate that our revenues for the remainder of 2008 and for 2009 will greatly depend upon our ability to sell Nano eNablerTM systems and our recently launched Cyto eNablerTM system for cell biologists, and acceptance of our recently launched service to perform custom surface patterning.



We believe that our gross margins as a percentage of revenues will increase as our manufacturing volumes increase and opportunities for efficiencies of scale are realized.



We expect our levels of operating expenses to increase as our business expands.  In particular, we foresee increases in our sales and marketing expenditures as we seek to increase access to the available markets for our products.



Our research and development expenditures will reduce in future quarters as a result of having transferred four of our employees to Aspera Corp. in August 2008, and our Chief Scientific Officer role changing to a part-time rather than full-time position as of September 1, 2008.



Our reimbursement of grant expenses will decrease in future periods due to our transfer of grants related to the technology that we licensed to Aspera Corp.



Liquidity and Capital Resources



Our cash reserves were $12,177 on September 30, 2008, as compared to $268,930 as of December 31, 2007.   Our net working capital deficit at September 30, 2008 was $470,102, as compared to net working capital of $1,072,145 at December 31, 2007.  The decrease in working capital is attributable to our loss from operations during the first nine months of 2008.



We used $788,357 of cash in our operating activities during the nine month period ended September 30, 2008, as compared to $2,028,829 in the first nine months of 2007 for these purposes.



We used cash of $126,434 during the first nine months of 2008 to purchase equipment and pay for the costs of patenting and trademarking our intellectual property, as compared to $400,754 for these purposes during the nine months ended September 30, 2007.



During the first nine months of 2008 we used $48,857 to make payments on long-term debts, as compared to $46,909 during the first nine months of 2007 for this purpose.



During the nine months ended September 30, 2008 we received net proceeds of $580,000 from the sale of our 8% convertible secured promissory notes and Common Stock purchase warrants.  During the first nine months of 2007 we received net cash proceeds of $360,840 from the sale of shares of our Series A Convertible Preferred Stock and warrants to purchase shares of our Common Stock.



19







We have been financed to date through revenues from sale of our products, private equity offerings, loans from related parties, governmental grants and loans from government entities.  While our revenues have been increasing, and we expect this trend to continue, we anticipate that we will continue to require external financing in order to fund our operations.



During the first quarter of 2008 we put into place an accounts receivable factoring facility with a finance company.  This facility gives us the opportunity to accelerate the availability of cash from the sale of our products.  Subject to the finance companys approval of the credit of the individual customer, we are able to sell customer invoices and receive advances of 80% of the amounts invoiced to domestic customers, with the remainder of the invoice amount, less financing costs, paid to us at the time that the customer pays the invoice.  We received $492,313 in proceeds from this arrangement during the first nine months of 2008, and made repayments of $341,708 during the same period.



During the first quarter of 2008 we put into place a master equipment lease agreement with a lease finance company.  This agreement allows us to obtain lease financing for up to $150,000 of computer and scientific laboratory equipment through December 31, 2008.  We were able to complete two sale/leaseback transactions during the second quarter of 2008 under the terms of this agreement, generating $31,313 of proceeds from the sale and leaseback of certain computer and scientific equipment purchased in prior quarters.



It is our intention to continue to augment our cash reserves via the issuance of our equity securities in private placements, or by incurring additional debt, in amounts such that we will be able to finance our continuing operations. We have engaged the services of several investment banking firms and placement agents to assist us with our efforts to attract investment capital.  If we are unable to identify additional sources of capital, we will be required to limit certain of our business activities, including sales and marketing expenditures as well as research and development activities, and eventually, if we are unable to secure additional capital, cease operations.



Due to the fact that we are still at an early stage of development of the market for the Nano eNablerTM system and our other products, we have sustained significant operating losses and are dependent upon debt and equity financing and increased revenues from the sale of our Nano eNablerTM system and other products to fund our future operations.  Our ability to continue as a going concern is dependent on our ability to raise capital for marketing our products and to increase revenues to cover operating expenses.  If we are unable to secure adequate financing or increase revenues, there is substantial doubt about our ability to continue as a going concern.



We need to obtain additional capital no later than November 30, 2008 in order to sustain our operations.  While it is possible that we will be able to generate some of the needed capital via sales of our products and services, our need to obtain additional debt or equity financing is clear, and such financing likely must be obtained by November 30, 2008 for us to meet our obligations to employees and vendors in a manner that avoids the disruption of our operations.



Off-Balance Sheet Arrangements



We are not a party to any off-balance sheet arrangements.





Item 3.  Quantitative and Qualitative Disclosures About Market Risk.



None.



Item 4.  Controls and Procedures.



Evaluation of Disclosure Controls and Procedures



Our management is responsible for establishing and maintaining effective disclosure controls and procedures. Our disclosure controls and procedures (as defined in Rule 13a-15(e) and Rule 15d-15(e) under the Securities Exchange Act of 1934, as amended) are designed to ensure that information required to be disclosed in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commissions (SEC) rules and forms, and that such information is accumulated and communicated to our management, including our principal executive and principal financial officers, as appropriate, to allow timely decisions regarding required disclosure.



20







As of the end of the period covered by this report, and with the participation of our principal executive officer and our principal financial officer, we evaluated the effectiveness of our disclosure controls and procedures. Certain weaknesses in the disclosure controls and procedures were identified prior to or during this quarter and in our Annual Report on Form 10-KSB for the year ended December 31, 2007.  These material weaknesses were described in that report as follows.



1)

Certain control procedures were unable to be verified due to performance of the procedure not being sufficiently documented.  As an example, some procedures requiring review of certain reports could not be verified due to there being no written notation on the report by the reviewer.  Because we were unable to verify these procedures, we conclude that as of December 31, 2007 there were control deficiencies related to the preparation and review of our interim and annual consolidated financial statements, in particular with respect to certain account reconciliations, journal entries and spreadsheets, and the authorization of sales transactions and customer billing rates.  While none of these control deficiencies resulted in audit adjustments to our 2007 interim or annual consolidated financial statements, they could result in a material misstatement to our interim or consolidated financial statements that would not be prevented or detected, and therefore we have determined that these control deficiencies constitute material weaknesses.



2)

Certain of our personnel had access to various financial application programs and data that was beyond the requirements of their individual job responsibilities.  While this control deficiency did not result in any audit adjustments to our 2007 interim or annual consolidated financial statements, it could result in a material misstatement to our interim or consolidated financial statements that would not be prevented or detected, and therefore we have determined that this control deficiency constitutes a material weakness.



3)

We did not maintain a level of personnel sufficient to execute certain computing controls over our information technology structure.  While this control deficiency did not result in any audit adjustments to our 2007 interim or annual consolidated financial statements, it could result in a material misstatement to our interim or consolidated financial statements that would not be prevented or detected, and therefore we have determined that this control deficiency constitutes a material weakness.



4)

We did not maintain adequate segregation of duties within certain areas impacting our financial reporting.  While this control deficiency did not result in any audit adjustments to our 2007 interim or annual consolidated financial statements, it could result in a material misstatement to our interim or consolidated financial statements that would not be prevented or detected, and therefore we have determined that this control deficiency constitutes a material weakness.



To the extent reasonably possible given our resources, we will seek the advice of outside consultants and utilize internal resources to implement additional internal controls to address the above identified material weaknesses.  We are taking steps to implement additional review and approval procedures applicable to our financial reporting process, and are in the planning phase of creating and implementing new information technology policies and procedures related to controls over information technology operations, security and change management.



Through these steps, we believe that we are addressing the deficiencies that affected our internal control over financial reporting as of December 31, 2007.  Because the remedial actions require upgrading certain of our information technology systems, relying extensively on manual review and approval processes, and possibly hiring of additional personnel, we may not be able to conclude that these material weaknesses have been remedied until these controls have been successfully operation for some period of time.



Due to these material weaknesses, we conclude that for the three and nine month periods ended September 30, 2008, and as of September 30, 2008, the design and operation of our disclosure controls and procedures were not effective. We will be reporting on the progress of our efforts to correct these deficiencies in future reports.



Changes in Internal Control over Financial Reporting



There was no change in our internal control over financial reporting that occurred during the period covered by this report that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.





21





Item 4A(T).  Controls and Procedures.



Not applicable.



PART II  OTHER INFORMATION



Item 1.  Legal Proceedings.



None



Item 1A.  Risk Factors.



Not applicable.



Item 2.  Unregistered Sales of Equity Securities and Use of Proceeds.



Please refer to the Current Report filed on Form 8-K on July 24, 2008 for details of our sale of 8% convertible secured promissory notes and Common Stock purchase warrants.



On June 30, 2008, our Board of Directors approved the issuance of 100,000 Common Stock purchase warrants, with a grant date of July 15, 2008 and an exercise price equal to the fair market value of the common stock on July 15, 2008, to our Executive Vice President and Chief Scientific Officer, Dr. Eric Henderson, who is also a member of our Board of Directors, in recognition of his past deferral of a portion of his compensation to support the Companys cash flow position.  That warrant was in fact issued on July 15, 2008, with an exercise price of $0.20 per share.  It expires five years after the issuance date and is fully vested.  Our grant of the warrant to Dr. Henderson was made in reliance on an exemption from registration provided by Section 4(2) of the Securities Act of 1933 (the Securities Act).  Dr. Henderson represents himself as an accredited investor as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.



On June 30, 2008, our Board of Directors gave our management certain authority to approve the issuance of up to 300,000 Common Stock purchase warrants to be used to engage the services of consultants to the Company.  On July 7, 2008, we issued 30,000 Common Stock purchase warrants to Mr. David Holbrook, and 20,000 Common Stock purchase warrants to Mr. Steven Nielsen, pursuant to that authorization, in exchange for financial advisory services related to our efforts to raise capital.  The warrants issued to Mr. Holbrook and Mr. Nielsen each expire five years after the issuance date and have an exercise price of $0.32 per share.  Our grants of the warrants to Mr. Holbrook and Mr. Nielsen were made in reliance on an exemption from registration provided by Section 4(2) of the Securities Act of 1933 (the Securities Act).  Mr. Holbrook and Mr. Nielsen represent themselves as an accredited investors as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.



On June 30, 2008, our Board of Directors approved the issuance of Common Stock purchase warrants to employees of the Company who might occasionally defer a portion of their pay in order to support our cash flow position.  Pursuant to this approval, one Common Stock purchase warrant is to be issued for each $1.00 of deferred pay, with an exercise price at the fair market value of our Common Stock on the date of deferral.  A second Common Stock purchase warrant is to be issued for each $1.00 of deferred pay if the deferral remains outstanding after one month, with that warrant having an exercise price at the fair market value of our Common Stock on the date that is one month after the original deferral date.  A third and final Common Stock purchase warrant is to be issued for each $1.00 of deferred pay if the deferral remains outstanding after three months, with that warrant having an exercise price at the fair market value of our Common Stock on the date that is three months after the original deferral date.  On September 22, 2008, we issued 8,715, 6,632, and 4,167 Common Stock purchase warrants to Mr. Kerry M. Frey, Mr. Gregory D. Brown, and Dr. Eric R. Henderson, respectively, under this program.  Mr. Frey is a Director and our President and Chief Executive Officer, Mr. Brown is our Executive Vice President and Chief Financial Officer, and Dr. Henderson is a Director and our Executive Vice President and Chief Scientific Officer.  Each of these warrants expires five years after the date of issuance and has an exercise price of $0.15 per share.  Our grants of the warrants to Mr. Frey, Mr. Brown and Dr. Henderson were made in reliance on an exemption from registration provided by Section 4(2) of the Securities Act of 1933 (the Securities Act).  Mr. Frey, Mr. Brown and Dr. Henderson represent themselves as an accredited investors as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.



Item 3.  Defaults Upon Senior Securities.



22





We are not in default under any of our borrowing agreements, and have received no notices of default from our lenders.



At present, we are in arrears, in the aggregate amount of $28,693, in our scheduled payments on loans from state and local governmental agencies.  This arrearage is a result of us applying our cash resources to best support our operational needs.



Item 4.  Submission of Matters to a Vote of Security Holders.



None



Item 5.  Other Information.



None.



Item 6.  Exhibits.



|                                                                    |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
|------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit #                                                           | Description of Exhibits                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|2.1(1)                                                              | Agreement and Plan of Merger among Silver River Ventures, Inc., Silver River Acquisitions, Inc., BioForce Nanosciences, Inc., H. Deworth Williams and Edward F. Cowle dated November 30, 2005, with Addenda dated December 23, 2005 and February 15, 2006                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
|3.1(2)                                                              | Articles of Incorporation, as amended                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|3.2(3)                                                              | Certificate of Designation of Series A Convertible Preferred Stock                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|3.3(4)                                                              | By-Laws (as amended)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|4.1(3)                                                              | Form of Series A Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.2(3)                                                              | Form of Series B Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.3(3)                                                              | Form of Series C Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.4(3)                                                              | Form of Series D Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.5(3)                                                              | Form of Series E Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.6(3)                                                              | Form of Series J Warrant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
|4.7(3)

4.8(4)


4.9(4)


4.10(10)


4.11(11)


4.12(12)


4.13(12) | Form of Series P Warrant

Promissory Note between Bioforce Nanosciences, Inc. and the Iowa Department of Economic Development PIAP Program dated November 5, 2007

User Service Agreement dated March 17, 2008 between BioForce Nanosciences Holdings, Inc. and CJM Financial, Inc.

Form of Convertible Secured Promissory Note between BioForce Nanosciences Holdings, Inc. and various purchasers dated June 10, 2008

Form of Warrant to Purchase Shares of Common Stock issued to various purchasers dated June 10, 2008

Comvertible Secured Promissory Note between BioForce Nanosciences Holdings, Inc. and FCPR SGAM Biotechnology Fund dated July 21, 2008

Warrant to Purchase Shares of Common Stock issued to FCPR SGAM Biotechnology Fund dated July 21, 2008



23







|                    |                                                                                                                                                                                                                                                                   
|------------------- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|5.1(9)              | Legality Opinion                                                                                                                                                                                                                                                  
|10.1(2)             | Amended and Restated Registration Rights Agreement between BioForce Nanosciences, Inc. and FCPR SGAM Biotechnology Fund dated October 14, 2002                                                                                                                    
|10.2(2)             | Form of Lock-up/Leak-out Agreements dated September 6, 2006 between BioForce Nanosciences Holdings, Inc. and five shareholders including Eric Henderson, Harvey Kaye, and FCPR SGAM Biotechnology Fund                                                            
|10.3(2)             | Consulting Agreement between BioForce Nanosciences Holdings, Inc. and Gulfstream Capital Group, LLC, dated November 15, 2006                                                                                                                                      
|10.4(2)             | Letter canceling prior agreements between Gulfstream Capital Group, L.C. and BioForce Nanosciences Holdings, Inc., dated December 12, 2006                                                                                                                        
|10.5(2)             | Commercial Lease between BioForce Nanosciences, Inc. and Randall Corporation dated November 19, 2004, as amended January 2, 2007                                                                                                                                  
|10.6(9)             | Lease Amendment Number 2, dated September 20, 2007, between Randall Corporation and BioForce Nanosciences, Inc.                                                                                                                                                   
|10.7(5)             | Employment Agreement between Eric Henderson and BioForce Nanosciences Holdings, Inc., dated April 1, 2006                                                                                                                                                         
|10.8(8)

10.9(10)   | Amendment Number 1 to Employment Agreement between Eric Henderson and BioForce Nanosciences Holdings, Inc., dated June 13, 2007
Amendment Number 2 to Employment Agreement between Eric Henderson and BioForce Nanosciences Holdings, Inc., dated January 21, 2008
|10.10(2)            | Employment Agreement between Kerry Frey and BioForce Nanosciences Holdings, Inc., dated June 1, 2006                                                                                                                                                              
|10.11(8)

10.12(10) | Amendment Number 1 to Employment Agreement between Kerry Frey and BioForce Nanosciences Holdings, Inc., dated June 13, 2007
Amendment Number 2 to Employment Agreement between Kerry Frey and BioForce Nanosciences Holdings, Inc., dated January 21, 2008        
|10.13(6)            | Employment Letter between Gregory D. Brown and BioForce Nanosciences dated December 27, 2006                                                                                                                                                                      
|10.14(8)            | Employment Agreement between Gregory D. Brown and BioForce Nanosciences Holdings, Inc., dated as of August 13, 2007                                                                                                                                               
|10.15(2)            | Summary of Consulting Arrangement between Kerry M. Frey and BioForce Nanosciences for 2005 and 2006                                                                                                                                                               
|10.16(2)            | Summary of Compensation for Directors of BioForce Nanosciences Holdings, Inc.                                                                                                                                                                                     
|10.17(7)            | BioForce Nanosciences Holdings, Inc. 2006 Equity Incentive Plan                                                                                                                                                                                                   
|10.18(2)            | Form of Stock Option Agreement for BioForce Nanosciences Holdings, Inc. 2006 Equity Incentive Plan                                                                                                                                                                
|10.19(8)            | BioForce Nanosciences Holdings, Inc. Amended and Restated 2006 Equity Incentive Plan                                                                                                                                                                              
|10.20(8)            | Form of Stock Option Agreement for BioForce Nanosciences Holdings, Inc. Amended and Restated 2006 Equity Incentive Plan                                                                                                                                           
|10.21(2)            | BioForce Nanosciences, Inc. 2003 Stock Option Plan                                                                                                                                                                                                                
|10.22(2)            | Form of Stock Option Agreement for BioForce Nanosciences, Inc. 2003 Stock Option Plan                                                                                                                                                                             
|10.23(2)            | Amended and Restated BioForce Nanosciences, Inc. 2000 Stock Incentive Plan                                                                                                                                                                                        
|10.24(2)            | Form of Incentive Stock Option Agreement for Amended and Restated BioForce Nanosciences, Inc. 2000 Stock Incentive Plan                                                                                                                                           
|10.25(2)            | Form of BioForce Nanosciences, Inc. Warrant for the Purchase of Shares of Common Stock                                                                                                                                                                            



24





|                                                                                                             |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|------------------------------------------------------------------------------------------------------------ | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.26(2)                                                                                                     | Form of BioForce Nanosciences, Inc. Warrant for the Purchase of Shares of Common Stock with Registration Rights, as issued to Gulfstream Capital Group, LLC                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
|10.27(2)                                                                                                     | Community Economic Betterment Account (CEBA) Venture Project Component Royalty Agreement, dated July 10, 2001                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
|10.28(2)                                                                                                     | Iowa Department of Economic Development PIAP Loan Agreement, awarded March 14, 2003                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
|10.29(2)                                                                                                     | City of Ames Economic Development Revolving Loan Fund Program Loan Agreement, executed January 28, 2005                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
|10.30(2)                                                                                                     | Economic Development Community Investment Fund Program Loan Agreement, executed February 24, 2005                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
|10.31(2)                                                                                                     | Note and Warrant Purchase Agreement between BioForce Nanosciences, Inc. and FCPR SGAM Biotechnology Fund, dated as of July 29, 2005                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
|10.32(3)                                                                                                     | Form of Series A Convertible Preferred Stock and Warrant Purchase Agreement, dated August 31, 2007                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
|10.33(3)                                                                                                     | Form of Registration Rights Agreement, dated August 31, 2007                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|10.34(3)                                                                                                     | Form of Lock-Up Agreement, dated August 31, 2007                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
|10.35(3)                                                                                                     | Letter Agreement, dated July 12, 2007, between BioForce Nanosciences Holdings, Inc. and TriPoint Global Equities, LLC, as placement agent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
|10.36 (9)                                                                                                    | Form of Amendment Number 1 to the October 14, 2002 Amended and Restated Registration Rights Agreement, made effective as of September 29, 2007, between FCPR SGAM Biotechnology Fund and BioForce Nanosciences Holdings, Inc., as successor to BioForce Nanosciences, Inc.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|10.37 (11)



10.38(14)



10.39(11)


10.40(13)


10.41(13)


10.42(13)


10.43(15)


10.44(16)


10.45(16) | Amendment Number 2 to the October 14, 2002 Amended and Restated Registration Rights Agreement, made effective as of May 5, 2008, between FCPR SGAM Biotechnology Fund and BioForce Nanosciences Holdings, Inc., as successor to BioForce Nanosciences, Inc.

Amendment Number 3 to the October 14, 2002 Amended and Restated Registration Rights Agreement, made effective as of June 10, 2008, between FCPR SGAM Biotechnology Fund and BioForce Nanosciences Holdings, Inc., as successor to BioForce Nanosciences, Inc.

Master Lease Agreement between Relational, LLC and BioForce Nanosciences, Inc., dated March 28, 2008

License Agreement between Aspera Corp. and BioForce Nanosciences, Inc., dated August 11, 2008.

Shareholder Agreement between Aspera Corp., BioForce Nanosciences, Inc. and various other parties, dated August 11, 2008

Employment Agreement between BioForce Nanosciences, Inc. and Eric Henderson, dated August 11, 2008

Agreement Regarding SPT Grant between Aspera Corp. and BioForce Nanosciences, Inc., dated August 27, 2008

Amendment Number 3 to Employment Agreement between Kerry Frey and BioForce Nanosciences Holdings, Inc., dated November 6, 2008

Amendment Number 1 to Employment Agreement between Gregory D. Brown and BioForce Nanosciences Holdings, Inc., dated November 10, 2008



25









|                       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
|---------------------- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|31.1

31.2

32.1

32.2 | Certification of Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
Certification of Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002
Certification of Chief Executive Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002
Certification of Chief Financial Officer Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002



(1)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on March 2, 2006.

(2)

Incorporated by reference to an exhibit filed with our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2006, filed on April 2, 2007.

(3)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on September 7, 2007.

(4)

Incorporated by reference to an exhibit filed with our Annual Report on Form 10-KSB for the fiscal year ended December 31, 2007, filed on March 31, 2008.

(5)

Incorporated by reference to an exhibit to our Quarterly Report on Form 10-QSB for the quarter ended June 30, 2006, filed on August 7, 2006.

(6)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on January 16, 2007.

(7)

Incorporated by reference to Appendix B of our Schedule 14C Information Statement filed on January 10, 2006.

(8)

Incorporated by reference to an exhibit to our Quarterly Report on Form 10-QSB for the quarter ended June 30, 2007, filed on August 14, 2007.

(9)

Incorporated by reference to an exhibit filed with our Registration Statement on Form SB-2 on October 1, 2007.



(10)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on June 16, 2008.



(11)

Incorporated by reference to an exhibit to our Quarterly Report on Form 10-QSB for the quarter ended March 31, 2008, filed on May 15, 2008.



(12)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on July 24, 2008



(13)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on August 13, 2008



(14)

Incorporated by reference to an exhibit filed with our Registration Statement on Form S-1 on July 11, 2008



(15)

Incorporated by reference to an exhibit filed with our Registration Statement on Form S-1 on September 9, 2008



(16)

Incorporated by reference to an exhibit filed with our Current Report on Form 8-K on November 12, 2008







SIGNATURES



26











In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



BioForce Nanosciences Holdings, Inc.





Date:  November 14, 2008

/s/ Kerry M. Frey

Kerry M. Frey

Chief Executive Officer





Date:  November 14, 2008

/s/ Gregory D. Brown

Gregory D. Brown

Chief Financial Officer





27



Exhibit 31.1



CERTIFICATION PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002



I, Kerry M. Frey, certify that:



1.

I have reviewed this quarterly report on Form 10-Q of BioForce Nanosciences Holdings, Inc.;



2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;



3.

The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a  15(f) and 15d  15(f)) for the registrant and have:



(a)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the small business issuer, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;



(b)

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;



(c)

Evaluated the effectiveness of the registrants disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and





(d)

Disclosed in this report any change in the registrants internal control over financial reporting that occurred during the registrants most recent fiscal quarter (the registrants fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrants internal control over financial reporting.



4.

The registrants other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrants auditors and the audit committee of the registrants board of directors (or persons performing the equivalent functions):



(a)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report financial information; and



(b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrants internal control over financial reporting.



Date:  November 14, 2008





/s/ Kerry M. Frey

Kerry M. Frey

Principal Executive Officer





Exhibit 31.2



CERTIFICATION PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002



I, Gregory D. Brown, certify that:



1.

I have reviewed this quarterly report on Form 10-Q of BioForce Nanosciences Holdings, Inc.;



2.

Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;



3.

The registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a  15(f) and 15d  15(f)) for the registrant and have:



(a)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the small business issuer, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;



(b)

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;



(c)

Evaluated the effectiveness of the registrants disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and



(d)

Disclosed in this report any change in the registrants internal control over financial reporting that occurred during the registrants most recent fiscal quarter (the registrants fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrants internal control over financial reporting.



4.

The registrants other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrants auditors and the audit committee of the registrants board of directors (or persons performing the equivalent functions):



(a)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrants ability to record, process, summarize and report financial information; and



(b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrants internal control over financial reporting.



Date:  November 14, 2008





/s/ Gregory D. Brown

Gregory D. Brown

Principal Financial Officer





Exhibit 32.1



CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002



In connection with the Quarterly Report of BioForce Nanosciences Holdings, Inc. (the Company) on Form 10-Q for the period ended September 30, 2008, as filed with the Securities and Exchange Commission on the date hereof (the Report), I, Kerry M. Frey, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:



(1)

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and



(2)

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.





/s/ Kerry M. Frey

Kerry M. Frey

Chief Executive Officer

November 14, 2008







A signed original of this written statement required by Section 906, or other document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.  The foregoing certifications are accompanying the Company's Form 10-Q solely pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code) and are not being filed as part of the Form 10-Q or as a separate disclosure document.





Exhibit 32.2



CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002



In connection with the Quarterly Report of BioForce Nanosciences Holdings, Inc. (the "Company") on Form 10-Q for the period ended September 30, 2008, as filed with the Securities and Exchange Commission on the date hereof (the "Report"), I, Gregory D. Brown, Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that, to the best of my knowledge:



(1)

The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and



(2)

The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.





/s/ Gregory D. Brown

Gregory D. Brown

Chief Financial Officer

November 14, 2008







A signed original of this written statement required by Section 906, or other document authenticating, acknowledging, or otherwise adopting the signature that appears in typed form within the electronic version of this written statement has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.  The foregoing certifications are accompanying the Company's Form 10-Q/ solely pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of section 1350, chapter 63 of title 18, United States Code) and are not being filed as part of the Form 10-Q or as a separate disclosure document.