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Title:   Author  item
                                            SHEN, C-L - Texas Tech Universityitem
                                            YEH, J - Winthrop University Hospitalitem
                                            Cao, Jayitem
                                            TENNER, TOM - Texas Tech Universityitem
                                            WANG, J-S - University Of Georgia
  Submitted to: Journal of Bone and Mineral Research
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/30/2010
                                    Publication  Date: 12/10/2010
                                    Citation: Shen, C., Yeh, J.K., Cao, J.J., Tenner, T., Wang, J. 2010. Green tea polyphenols supplementation improves bone microstructure in orchidectomized middle-Aged rats [abstract]. Journal of Bone and Mineral Research. 25(Supplement1).Interpretive Summary:
                                Technical Abstract: Our recent study shows that green tea polyphenols (GTP) attenuate trabecular bone loss in ovariectomized middle-aged female rats. To investigate whether GTP prevents bone loss in male rats, 40 rats with and without oriectomy (ORX) were assigned to 4 groups in a 2 (sham vs. ORX)× 2 (no GTP and 0.5% GTP in drinking water) factorial design for 16 wks. Efficacy was evaluated in femur and tibia microarchitecture by μCT and histomorphometric analysis, respectively. ORX decreased trabecular bone volume, number and thickness in distal femur and proximal tibia, but increased bone formation rates in cancellous proximal tibia as well as endocortical tibial shaft. The results of two-way ANOVA show that GTP supplementation significantly increased trabecular bone volume (F value=5.4, P=0.025), thickness (F value = 6.5, P=0.015), and bone formation rates in both proximal tibia (F value=14.0, P<0.001) and periosteal tibial shaft (F value=4.1, P=0.049), but decreased eroded surface in both proximal tibia (F value=17.3, P<0.001) and endocortical tibial shaft (F value=4.2, P=0.047). This study demonstrates that GTP supplemention in drinking water for 16 weeks prevents trabecular bone loss through increasing bone formation while suppressing bone resorption. The results in this animal model merit investigation of a potentially significant prophylactic role of green tea in bone health of elderly men.


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