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Title:   Author  item
                                            Rue, Caryitem
                                            SUSTA, LEONARDO - UNIV GEORGIAitem
                                            BROWN, CORRIE - UNIV GEORGIAitem
                                            Kapczynski, Darrellitem
                                            Miller, Pattiitem
                                            King, Danielitem
                                            Suarez, Daviditem
                                            Afonso, Claudio
  Submitted to: American Association of Avian Pathologists
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/20/2008
                                    Publication  Date: 5/8/2009
                                    Citation: Rue, C.A., Susta, L., Brown, C.C., Kapczynski, D.R., Miller, P.J., King, D.J., Suarez, D.L., Afonso, C.L. 2009. A highly virulent strain of Newcastle disease virus elicits a strong innate response and nitric oxide production in chickens [abstract]. American Association of Avian Pathologists Annual Meeting, July 11-14, 2009, Seattle, Washington. p. 16.Interpretive Summary:
                                Technical Abstract: The avian immune response to Newcastle disease virus (NDV) and the contribution of this response to disease are not well understood.  In this study, the transcriptional host response of chickens to a virulent NDV outbreak strain (California 2002) was characterized in vivo.  Using microarray, a strong host response was observed in spleens at early times post-infection with the induction of numerous innate anti-viral and pro-inflammatory response genes.  The robust host response to NDV shown here, in conjunction with severe pathological damage observed, suggest that the host response itself may significantly contribute to the rapid mortality of this outbreak strain.


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