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Title:   Author  item
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            ARTHINGTON, JOHN - UNIV OF FLORIDA-ONAitem
                                            Chase, Chadwick

                                                         - *Chad*item
                                            Coleman, Samuelitem
                                            Riley, Daviditem
                                            SPIERS, DON - UNIV OF MISSOURI-COLUMBIAitem
                                            REUTER, RYAN - THE NOBEL FOUNDATION, INC
  Submitted to: American Society of Animal Science Southern Section Meeting
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 11/13/2007
                                    Publication  Date: 7/15/2008
                                    Citation: Carroll, J.A., Arthington, J., Chase Jr., C.C., Coleman, S.W., Riley, D.G., Spiers, D., Reuter, R. 2008. Genetic influences on the bovine acute phase protein response following an endotoxin challenge [abstract]. Journal of Animal Science. 86(Suppl. 2):21. (Abstract #79)Interpretive Summary:
                                Technical Abstract: Previously we reported that the pro-inflammatory cytokine response following an endotoxin challenge differs between diverse Bos taurus breeds [i.e., Angus (AG) and Romosinuano (RO)]. Our current objective was to elucidate potential genetic differences in the acute phase protein (APP) response following an endotoxin challenge. Eighteen steers (n = 9 steers/breed; 299.4 ± 5.2 Kg BW) were acclimated to environmentally controlled chambers maintained at 19.7 deg C and then fitted with indwelling jugular catheters one day prior to LPS challenge. The following day, blood samples were collected at 30-min intervals from -2 to 8 h. At 0 h, all steers received an i.v. injection of LPS (2.5 ug/Kg BW). Serum was stored at -80 deg C until analyzed for acid soluble protein (ASP), ceruloplasmin (CPN), and serum amyloid A (SAA). Data were analyzed using an ANOVA specific for repeated measures. Of the 3 APP evaluated, only SAA concentrations increased (P < 0.01) following the LPS challenge. By 4 h post-LPS, SAA concentrations increased (P < 0.01) above baseline and remained elevated throughout the remainder of the study. While the overall SAA response profiles were similar between AG and RO steers, the response was greater (P < 0.02) in AG as compared to RO steers. As with SAA, CPN response profiles were similar in AG and RO steers, however, a breed effect (P < 0.01) was observed such that CPN concentrations were greater in the RO steers compared to AG steers. Prior to LPS challenge, CPN concentrations tended (P < 0.06) to be greater in RO steers. While serum concentrations of ASP decreased throughout the sampling period (P < 0.01), there was no effect of breed. Given that SAA concentrations may be more indicative of the stress an animal is experiencing as opposed to a direct indicator of acute inflammation, the lower concentrations of SAA in the Romo steers may indicate that they were more resilient to the LPS challenge. Continued efforts to elucidate potential genetic differences in cattle breeds as they relate to overall health and productivity will aid in our ability to more effectively manage cattle throughout the production cycle.


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