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ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





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Title:   Author  item
                                            TAMGUNEY, GULTEKIN - University Of Californiaitem
                                            Richt, Juergenitem
                                            Hamir, Amiraliitem
                                            Greenlee, Justinitem
                                            MILLER, MICHAEL - Colorado Division Of Wildlifeitem
                                            WOLFE, LISA - Colorado Division Of Wildlifeitem
                                            SIROCHMAN, TRACEY - Colorado Division Of Wildlifeitem
                                            YOUNG, ALAN - South Dakota State Universityitem
                                            GLIDDEN, DAVID - University Of Californiaitem
                                            JOHNSON, NATRINA - University Of Californiaitem
                                            LEMUS, AZUCENA - University Of Californiaitem
                                            DEARMOND, STEPHEN - University Of Californiaitem
                                            PRUSINER, STANLEY - University Of California
  Submitted to: Prion
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/29/2011
                                    Publication  Date: 1/1/2012
                                    Citation: Tamguney, G., Richt, J.A., Hamir, A.N., Greenlee, J.J., Miller, M.W., Wolfe, L.L., Sirochman, T.M., Young, A.J., Glidden, D.V., Johnson, N.L., Giles, K., Dearmond, S.J., Prusiner, S.B. 2012. Salivary prions in sheep and deer. Prion. 6(1):52-61.Interpretive Summary: Scrapie is a neurodegenerative disease of sheep and goats that is caused by infectious agents called prions. This manuscript identifies saliva as a potential route of scrapie transmission.   When saliva from sheep clinically affected with scrapie is inoculated into the brain of mice expressing an ovine prion gene, a high percentage of the mice develop scrapie. This provides evidence that sheep saliva contains infectious prions, however, additional experiments will be required to determine if the infectivity of sheep saliva is sufficient to cause scrapie transmission under natural conditions. Results of this study will potentially impact sheep producers and regulatory agencies involved in scrapie prevention since this is significant new information about scrapie transmission.
                                Technical Abstract: Scrapie is a prion disease transmitted naturally within affected host populations of sheep and goats. Although milk and placenta have been identified as sources of contagion for scrapie prions, these sources seem insufficient to explain either indirect or interspecies scrapie transmission. Here we show that scrapie-infected sheep secrete prions in their saliva, thereby providing a plausible natural shedding mechanism that might explain the horizontal transmission of scrapie.


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