The
                Children’s Hospital of
                Philadelphia

              Joseph
                Stokes, Jr., Research Institute

              Department
                of Sponsored Projects

              3615
                Civic Center Blvd. ARC 142

              Philadelphia,
                PA 19104-4318

              Phone
                267.426.0122

            


    


    CHOP
      Reference No. 22852-02-01

    


    MODIFICATION
      OF AGREEMENT 

    


    Modification
      of the Subcontract Agreement with the Targeted
      Genetics Corporation under
      the
National
      Institute of Health Contract Award
      #
HHSN2662005000008C,
      for support of a project entitled “HIV
      Vaccine Design and Development Teams”,
      with
      Dr. Philip Johnson serving as the Principal Investigator for CHOP and Drs.
      Barrie Carter and Pervin Anklesaria serving as the Project Directors for the
      Subawardee.

    


    Modification
      # 1

    


    


    This
      modification changed the following paragraphs as detailed below:

    

      
        	
                Article
                  2 Period of Performance.

              	 	
                Add
                  new period of performance: 8/31/06 to 8/30/07

              
	 	 	 
	
                Article
                  4.1 Estimated Costs

              	 	
                Authorize
                  additional costs for new year. Total costs for the new performance
                  period
                  are amended from $3,087,023 to add $5,707,854 for Year-2 shall
                  not exceed
                  $8,794,877 as detailed in new Attachment A.

              
	 	 	 
	All other
                terms and
                conditions remain unchanged.	 	 


      

    

     

     

    
      	
              CHOP
                Organizational Official

            	
              Targeted
                Genetics Corporation Organizational
                Official

            
	 	 	 	 	 	 
	
              Name:

            	 	
              Sara
                Dubberly

            	
              Name:

            	 	
              Barrie
                Carter

            
	
              Title:

            	 	
              Director,
                Dept. of Sponsored Projects

            	
              Title:

            	 	
              Senior
                Executive Vice President and Chief Scientific Officer

            
	
              Institution:

            	 	
              The
                Children's Hospital of Philadelphia

            	
              Institution:

            	 	
              Targeted
                Genetics Corporation

            
	 	 	
              The
                Joseph Stokes Jr. Research Institute

            	 	 	
               

            
	
              Address:

            	 	
              3615
                Civic Center Boulevard

            	
              Address:

            	 	
              1100
                Olive Way, Suite 100

            
	
              City,
                State:

            	 	
              Philadelphia,
                PA

            	
              City,
                State:

            	 	
              Seattle,
                WA

            
	
              Zip:

            	 	
              19104-4318

            	
              Zip:

            	 	
              98101

            
	 	 	 	 	 	 
	 	 	 	 	 	 
	Signature:	 	 /s/
              Sara Dubberly 	Signature:	 	/s/
              Barrie Carter
	 	 	 	 	 	 
	Date:
	 	October
              27, 2006	Date:
	 	October
              19, 2006


    

    


    
 

    
      
        
        

      

      
        
          The
            Children’s Hospital of
            Philadelphia

        

        
          

        

      

      
        
        

      

    

    

      
        	
                

              	
                The
                  Children’s Hospital of
                  Philadelphia

                Joseph
                  Stokes, Jr., Research Institute

                Department
                  of Sponsored Projects

                3615
                  Civic Center Blvd. ARC 142

                Philadelphia,
                  PA 19104-4318

                Phone
                  267.426.0122

              


      




    
 

    ATTACHMENT
      A

    


    


     

    
      
        	 	 	 	
                Budget

              	 
	 	 	 	 	 
	
                Total
                  Costs

              	 	
                $

              	
                8,794,877

              	 


      



    


    


    


    


    
      
        
        

      

      
        
          The
            Children’s Hospital of
            Philadelphia