# Patent

## Title
Aminomethyl substituted bicyclic aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor

## Abstract

The present invention relates to an aminomethyl substituted bicyclic aromatic compound of the formula I




The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a U.S. national stage entry of International Patent Application No. PCT/EP2005/011093, filed on Oct. 14, 2005, which claims priority to U.S. Provisional Patent Application No. 60/618,744, filed on Oct. 14, 2004, the contents of all of which are fully incorporated herein by reference.
BACKGROUND OF THE INVENTION
The present invention relates to novel aminomethyl substituted bicyclic aromatic compounds. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor.
Neurons obtain their information by way of G protein-coupled receptors, inter alia. A large number of substances exert their effect by way of these receptors. One of them is dopamine. Confirmed findings exist with regard to the presence of dopamine and its physiological function as a neurotransmitter. Disorders in the dopaminergic transmitter system result in diseases of the central nervous system which include, for example, schizophrenia, depression and Parkinson's disease. These diseases, and others, are treated with drugs which interact with the dopamine receptors.
Up until 1990, two subtypes of dopamine receptor had been clearly defined pharmacologically, namely the D1 and D2 receptors. More recently, a third subtype was found, namely the D3 receptor which appears to mediate some effects of antipsychotics and antiparkinsonians (J. C. Schwartz et al., The Dopamine D3 Receptor as a Target for Antipsychotics, in Novel Antipsychotic Drugs, H. Y. Meltzer, Ed. Raven Press, New York 1992, pages 135-144; M. Dooley et al., Drugs and Aging 1998, 12, 495-514, J. N. Joyce, Pharmacology and Therapeutics 2001, 90, pp. 231-59 “The Dopamine D3 Receptor as a Therapeutic Target for Antipsychotic and Antiparkinsonian Drugs”).
Since then, the dopamine receptors have been divided into two families. On the one hand, there is the D2 group, consisting of D2, D3 and D4 receptors, and, on the other hand, the D1 group, consisting of D1 and D5 receptors. Whereas D1 and D2 receptors are widely distributed, D3 receptors appear to be expressed regioselectively. Thus, these receptors are preferentially to be found in the limbic system and the projection regions of the mesolimbic dopamine system, especially in the nucleus accumbens, but also in other regions, such as the amygdala. Because of this comparatively regioselective expression, D3 receptors are regarded as being a target having few side-effects and it is assumed that while a selective D3 ligand would have the properties of known antipsychotics, it would not have their dopamine D2 receptor-mediated neurological side-effects (P. Sokoloff et al., Localization and Function of the D3 Dopamine Receptor, Arzneim. Forsch./Druq Res. 42(1), 224 (1992); P. Sokoloff et al. Molecular Cloning and Characterization of a Novel Dopamine Receptor (D3) as a Target for Neuroleptics, Nature, 347, 146 (1990)).
WO 95/04713, WO 96/23760 and WO 97/45403 disclose amino substituted bicyclic aromatic compounds having an affinity for the dopamine D3 receptor. Some of these compounds possess a certain selectivity for the dopamine D3 receptor in comparison with their affinity for the D2 receptor. They have therefore been proposed as being suitable for treating diseases of the central nervous system. Unfortunately their affinity and selectivity towards the D3 receptor is only moderate or their pharmacological profile are not satisfactory. Consequently there is an ongoing need to provide new compounds, which either have an high affinity and an improved selectivity. The compounds should also have good pharmacological profile, e.g. a high brain plasma ratio, a high bioavailability, good metabolic stability or a decreased inhibition of the mitochondrial respiration.
SUMMARY OF THE INVENTION
The invention is based on the object of providing compounds which act as highly selective dopamine D3 receptor ligands. This object is surprisingly achieved by means of aminomethyl substituted bicyclic aromatic compounds of the formula I




wherein

    
    
        Ar is a cyclic radical selected from the group consisting of phenyl, a 5- or 6-membered C-bound heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms which are, independently of each other, selected from O, S and N, and a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring, where the heterocyclic ring comprises as ring members 1, 2 or 3 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups each independently selected from NR8, where R8 is H, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkylcarbonyl or fluorinated C1-C4-alkylcarbonyl, and where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra;
        Ra is halogen, C1-C6-alkyl, fluorinated C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C6-alkyl, C2-C6-alkenyl, fluorinated C2-C6-alkenyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C1-C6-alkoxy, C1-C6-hydroxyalkoxy, C1-C6-alkoxy-C1-C6-alkoxy, fluorinated C1-C6-alkoxy, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfinyl, fluorinated C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, fluorinated C1-C6-alkylsulfonyl, CN, nitro, C1-C6-alkylcarbonyl, fluorinated C1-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, carboxy, NH—C(O)—NR4R5, NR4R5, NR4R5—C1-C6-alkylene, O—NR4R5, C(O)NR4R5, SO2NR4R5, phenylsulfonyl, benzyloxy, phenyl, phenoxy, or a saturated or unsaturated 3- to 7-membered heterocyclic ring comprising as ring members 1, 2, 3 or 4 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups selected from NR9, where R9 has one of the meanings given for R8, SO, SO2 and CO, and where the 5 last-mentioned radicals Ra may carry 1, 2, 3 or 4 substituents selected from hydroxy and the radicals Ra;
        X is a covalent bond or N—R2, CHR2, CHR2CH2, N or C—R2;
        Y is N—R2a, CHR2a, CHR2aCH2 or CHR2aCH2CH2;
         is a single bond or a double bond;
        E is CH2 or NR3;
        R1 is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl;
        R1a is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-alkenyl,
        R2 and R2a each independently are H, CH3, CH2F, CHF2 or CF3 or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2 or 3;
        R3 is H or C1-C4-alkyl;
        R4 and R5 independently of each other are H, C1-C4-alkyl, fluorinated C1-C4-alkyl or C1-C4-alkoxy or may form, together with N, a 4-, 5- or 6-membered saturated or unsaturated ring;
        R6 and R7 independently of each other are H or halogen;

and the physiologically tolerated acid addition salts thereof.

    
    


The present invention therefore relates to aminomethyl substituted bicyclic aromatic compounds of the general formula I and to their physiologically tolerated acid addition salts.
The present invention also relates to a pharmaceutical composition which comprises at least one aminomethyl substituted bicyclic aromatic compound of the formula I and/or at least one physiologically tolerated acid addition salt of I, where appropriate together with physiologically acceptable carriers and/or auxiliary substances.
The present invention also relates to a method for treating disorders which respond to influencing by dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one aminomethyl substituted bicyclic aromatic compound of the formula I and/or at least one physiologically tolerated acid addition salt of I to a subject in need thereof.


DETAILED DESCRIPTION OF THE INVENTION
The diseases which respond to the influence of dopamine D3 receptor antagonists or agonists include, in particular, disorders and diseases of the central nervous system, in particular affective disturbances, neurotic disturbances, stress disturbances and somatoform disturbances and psychoses, especially schizophrenia and depression and, in addition, disturbances of kidney function, in particular kidney function disturbances which are caused by diabetes mellitus (see WO 00/67847).
According to the invention, at least one compound of the general formula I having the meanings mentioned at the outset is used for treating the above mentioned indications.
Provided the compounds of the formula I of a given constitution may exist in different spatial arrangements, for example if they possess one or more centers of asymmetry, polysubstituted rings or double bonds, or as different tautomers, it is also possible to use enantiomeric mixtures, in particular racemates, diastereomeric mixtures and tautomeric mixtures, preferably, however, the respective essentially pure enantiomers, diastereomers and tautomers of the compounds of formula I and/or of their salts.
It is likewise possible to use physiologically tolerated salts of the compounds of the formula I, especially acid addition salts with physiologically tolerated acids. Examples of suitable physiologically tolerated organic and inorganic acids are hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, C1-C4-alkylsulfonic acids, such as methanesulfonic acid, aromatic sulfonic acids, such as benzenesulfonic acid and toluenesulfonic acid, oxalic acid, maleic acid, fumaric acid, lactic acid, tartaric acid, adipic acid and benzoic acid. Other utilizable acids are described in Fortschritte der Arzneimittelforschung [Advances in drug research], Volume 10, pages 224 ff., Birkhäuser Verlag, Basel and Stuttgart, 1966.
The organic moieties mentioned in the above definitions of the variables are—like the term halogen—collective terms for individual listings of the individual group members. The prefix Cn-Cm indicates in each case the possible number of carbon atoms in the group.
The term halogen denotes in each case fluorine, bromine, chlorine or iodine, in particular fluorine or chlorine.
C1-C4 Alkyl is a straight-chain or branched alkyl group having from 1 to 4 carbon atoms. Examples of an alkyl group are methyl, ethyl, n-propyl, iso-propyl, n-butyl, 2-butyl, iso-butyl or tert-butyl. C2-C4 Alkyl is ethyl, n-propyl, iso-propyl, n-butyl, 2-butyl, iso-butyl or tert-butyl. C1-C2 Alkyl is methyl or ethyl.
C1-C6 Alkyl is a straight-chain or branched alkyl group having from 1 to 6 carbon atoms. Examples include C1-C4 alkyl as mentioned above and also pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
Fluorinated C1-C6 alkyl is a straight-chain or branched alkyl group having from 1 to 6, in particular 1 to 4 carbon atoms, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by a fluorine atoms such as in fluoromethyl, difluoromethyl, trifluoromethyl, (R)-1-fluoroethyl, (S)-1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (R)-1-fluoropropyl, (S)-1-fluoropropyl, 2-fluoropropyl, 3-fluoropropyl, 1,1-difluoropropyl, 2,2-difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl, 1-(difluoromethyl)-2,2-difluoroethyl, (R)-1-fluorobutyl, (S)-1-fluorobutyl, 2-fluorobutyl, 3-fluorobutyl, 4-fluorobutyl, 1,1-difluorobutyl, 2,2-difluorobutyl, 3,3-difluorobutyl, 4,4-difluorobutyl, 4,4,4-trifluorobutyl, etc.;
Branched C3-C6 alkyl is alkyl having 3 to 6 carbon atoms at least one being a secondary or tertiary carbon atom. Examples are isopropyl, tert.-butyl, 2-butyl, isobutyl, 2-pentyl, 2-hexyl, 3-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl 1-methyl-1-ethylpropyl.
C1-C6 Alkoxy is a straight-chain or branched alkyl group having from 1 to 6, in particular 1 to 4 carbon atoms, which is bound to the remainder of the molecule via an oxygen atom. Examples include methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, 2-butoxy, iso-butoxy, tert.-butoxy pentyloxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexyloxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentyloxy, 2-methylpentyloxy, 3-methylpentyloxy, 4-methylpentyloxy, 1,1-dimethylbutyloxy, 1,2-dimethylbutyloxy, 1,3-dimethylbutyloxy, 2,2-dimethylbutyloxy, 2,3-dimethylbutyloxy, 3,3-dimethylbutyloxy, 1-ethylbutyloxy, 2-ethylbutyloxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy;
Fluorinated C1-C6 alkoxy is a straight-chain or branched alkoxy group having from 1 to 6, in particular 1 to 4 carbon atoms, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by a fluorine atoms such as in fluoromethoxy, difluoromethoxy, trifluoromethoxy, (R)-1-fluoroethoxy, (S)-1-fluoroethoxy, 2-fluoroethoxy, 1,1-difluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, (R)-1-fluoropropoxy, (S)-1-fluoropropoxy, 2-fluoropropoxy, 3-fluoropropoxy, 1,1-difluoropropoxy, 2,2-difluoropropoxy, 3,3-difluoropropoxy, 3,3,3-trifluoropropoxy, (R)-2-fluoro-1-methylethoxy, (S)-2-fluoro-1-methylethoxy, (R)-2,2-difluoro-1-methylethoxy, (S)-2,2-difluoro-1-methylethoxy, (R)-1,2-difluoro-1-methylethoxy, (S)-1,2-difluoro-1-methylethoxy, (R)-2,2,2-trifluoro-1-methylethoxy, (S)-2,2,2-trifluoro-1-methylethoxy, 2-fluoro-1-(fluoromethyl)ethoxy, 1-(difluoromethyl)-2,2-difluoroethoxy, (R)-1-fluorobutoxy, (S)-1-fluorobutoxy, 2-fluorobutoxy, 3-fluorobutoxy, 4-fluorobutoxy, 1,1-difluorobutoxy, 2,2-difluorobutoxy, 3,3-difluorobutoxy, 4,4-difluorobutoxy, 4,4,4-trifluorobutoxy, etc.;
C1-C6-Hydroxyalkyl is an alkyl radical having from 1 to 6 carbon atoms as defined above, wherein one hydrogen atom is replaced by hydroxy. Examples comprise hydroxymethyl, 2-hydroxyethyl, 1-hydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 1-methyl-1-hydroxyethyl and the like.
C1-C6-Hydroxyalkoxy is an alkoxy radical having from 1 to 6, preferably from 2 to 4 carbon atoms as defined above, wherein one hydrogen atom is replaced by hydroxy. Examples comprise 2-hydroxyethyl, 3-hydroxypropyl, 2-hydroxypropyl, 1-methyl-2-hydroxyethyl and the like.
C1-C6-Alkoxy-C1-C4-alkyl is an alkyl radical having from 1 to 4 carbon atoms as defined above, wherein one hydrogen atom is replaced by C1-C6 alkoxy. Examples comprise methoxymethyl, 2-methoxyethyl, 1-methoxyethyl, 3-methoxypropyl, 2-methoxypropyl, 1-methyl-1-methoxyethyl, ethoxymethyl, 2-ethoxyethyl, 1-ethoxyethyl, 3-ethoxypropyl, 2-ethoxypropyl, 1-methyl-1-ethoxyethyl and the like.
C1-C6-Alkoxy-C1-C4-alkoxy is an alkoxy radical having from 1 to 4 carbon atoms as defined above, wherein one hydrogen atom is replaced by C1-C6 alkoxy. Examples comprise methoxymethoxy, 2-methoxyethoxy, 1-methoxyethoxy, 3-methoxypropoxy, 2-methoxypropoxy, 1-methyl-1-methoxyethoxy, ethoxymethoxy, 2-ethoxyethoxy, 1-ethoxyethoxy, 3-ethoxypropoxy, 2-ethoxypropoxy, 1-methyl-1-ethoxyethoxy and the like.
C1-C6-Alkylcarbonyl is a radical of the formula R—C(O)—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise acetyl, propionyl, n-butyryl, 2-methylpropionyl, pivalyl and the like.
C1-C6-Alkylcarbonylamino is a radical of the formula R—C(O)—NH—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise acetamido, propionamido, n-butyramido, 2-methylpropionamido, 2,2-dimethylpropionamido and the like.
C1-C6 Alkylcarbonyloxy is a radical of the formula R—C(O)—O—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise acetyloxy, propionyloxy, n-butyryloxy, 2-methylpropionyloxy, 2,2-dimethylpropionyloxy and the like.
C1-C6 Alkoxycarbonyl is a radical of the formula RO—C(O)—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise methyloxycarbonyl, ethyloxycarbonyl, propyloxycarbonyl, isopropyloxycarbonyl and the like.
C1-C6 Alkylthio (also termed as C1-C6 alkylsulfanyl) is a radical of the formula R—S—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise methylthio, ethylthio, propylthio, butylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
C1-C6 Alkylsulfinyl is a radical of the formula R—S(O)—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise methylsulfinyl, ethylsulfinyl, propylsulfinyl, butylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, hexylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentylsulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3-dimethylbutylsulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3,3-dimethylbutylsulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
C1-C6 Alkylsulfonyl is a radical of the formula R—S(O)2—, wherein R is an alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise methylsulfonyl, ethylsulfonyl, propylsulfonyl, butylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl.
Fluorinated C1-C6 alkylcarbonyl is a radical of the formula R—C(O)—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise fluoroacetyl, difluoroacetyl, trifluoroacetyl, (R)-1-fluoroethylcarbonyl, (S)-1-fluoroethylcarbonyl, 2-fluoroethylcarbonyl, 1,1-difluoroethylcarbonyl, 2,2-difluoroethylcarbonyl, 2,2,2-trifluoroethylcarbonyl, (R)-1-fluoropropylcarbonyl, (S)-1-fluoropropylcarbonyl, 2-fluoropropylcarbonyl, 3-fluoropropylcarbonyl, 1,1-difluoropropylcarbonyl, 2,2-difluoropropylcarbonyl, 3,3-difluoropropylcarbonyl, 3,3,3-trifluoropropylcarbonyl, (R)-2-fluoro-1-methylethylcarbonyl, (S)-2-fluoro-1-methylethylcarbonyl, (R)-2,2-difluoro-1-methylethylcarbonyl, (S)-2,2-difluoro-1-methylethylcarbonyl, (R)-1,2-difluoro-1-methylethylcarbonyl, (S)-1,2-difluoro-1-methylethylcarbonyl, (R)-2,2,2-trifluoro-1-methylethylcarbonyl, (S)-2,2,2-trifluoro-1-methylethylcarbonyl, 2-fluoro-1-(fluoromethyl)ethylcarbonyl, 1-(difluoromethyl)-2,2-difluoroethylcarbonyl, (R)-1-fluorobutylcarbonyl, (S)-1-fluorobutylcarbonyl, 2-fluorobutylcarbonyl, 3-fluorobutylcarbonyl, 4-fluorobutylcarbonyl, 1,1-difluorobutylcarbonyl, 2,2-difluorobutylcarbonyl, 3,3-difluorobutylcarbonyl, 4,4-difluorobutylcarbonyl, 4,4,4-trifluorobutylcarbonyl, etc.
Fluorinated C1-C6 alkylcarbonylamino is a radical of the formula R—C(O)—NH—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise fluoroacetamido, difluoroacetamido, trifluoroacetamido, (R)-1-fluoroethylcarbonylamino, (S)-1-fluoroethylcarbonylamino, 2-fluoroethylcarbonylamino, 1,1-difluoroethylcarbonylamino, 2,2-difluoroethylcarbonylamino, 2,2,2-trifluoroethylcarbonylamino, (R)-1-fluoropropylcarbonylamino, (S)-1-fluoropropylcarbonylamino, 2-fluoropropylcarbonylamino, 3-fluoropropylcarbonylamino, 1,1-difluoropropylcarbonylamino, 2,2-difluoropropylcarbonylamino, 3,3-difluoropropylcarbonylamino, 3,3,3-trifluoropropylcarbonylamino, (R)-2-fluoro-1-methylethylcarbonylamino, (S)-2-fluoro-1-methylethylcarbonylamino, (R)-2,2-difluoro-1-methylethylcarbonylamino, (S)-2,2-difluoro-1-methylethylcarbonylamino, (R)-1,2-difluoro-1-methylethylcarbonylamino, (S)-1,2-difluoro-1-methylethylcarbonylamino, (R)-2,2,2-trifluoro-1-methylethylcarbonylamino, (S)-2,2,2-trifluoro-1-methylethylcarbonylamino, 2-fluoro-1-(fluoromethyl)ethylcarbonylamino, 1-(difluoromethyl)-2,2-difluoroethylcarbonylamino, (R)-1-fluorobutylcarbonylamino, (S)-1-fluorobutylcarbonylamino, 2-fluorobutylcarbonylamino, 3-fluorobutylcarbonylamino, 4-fluorobutylcarbonylamino, 1,1-difluorobutylcarbonylamino, 2,2-difluorobutylcarbonylamino, 3,3-difluorobutylcarbonylamino, 4,4-difluorobutylcarbonylamino, 4,4,4-trifluorobutylcarbonylamino, etc.
Fluorinated C1-C6 alkylcarbonyloxy is a radical of the formula R—C(O)—O—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above fluoroacetyl, difluoroacetyl, trifluoroacetyl, (R)-1-fluoroethylcarbonyloxy, (S)-1-fluoroethylcarbonyloxy, 2-fluoroethylcarbonyloxy, 1,1-difluoroethylcarbonyloxy, 2,2-difluoroethylcarbonyloxy, 2,2,2-trifluoroethylcarbonyloxy, (R)-1-fluoropropylcarbonyloxy, (S)-1-fluoropropylcarbonyloxy, 2-fluoropropylcarbonyloxy, 3-fluoropropylcarbonyloxy, 1,1-difluoropropylcarbonyloxy, 2,2-difluoropropylcarbonyloxy, 3,3-difluoropropylcarbonyloxy, 3,3,3-trifluoropropylcarbonyloxy, (R)-2-fluoro-1-methylethylcarbonyloxy, (S)-2-fluoro-1-methylethylcarbonyloxy, (R)-2,2-difluoro-1-methylethylcarbonyloxy, (S)-2,2-difluoro-1-methylethylcarbonyloxy, (R)-1,2-difluoro-1-methylethylcarbonyloxy, (S)-1,2-difluoro-1-methylethylcarbonyloxy, (R)-2,2,2-trifluoro-1-methylethylcarbonyloxy, (S)-2,2,2-trifluoro-1-methylethylcarbonyloxy, 2-fluoro-1-(fluoromethyl)ethylcarbonyloxy, 1-(difluoromethyl)-2,2-difluoroethylcarbonyloxy, (R)-1-fluorobutylcarbonyloxy, (S)-1-fluorobutylcarbonyloxy, 2-fluorobutylcarbonyloxy, 3-fluorobutylcarbonyloxy, 4-fluorobutylcarbonyloxy, 1,1-difluorobutylcarbonyloxy, 2,2-difluorobutylcarbonyloxy, 3,3-difluorobutylcarbonyloxy, 4,4-difluorobutylcarbonyloxy, 4,4,4-trifluorobutylcarbonyloxy, etc.
Fluorinated C1-C6 alkylthio (also termed as fluorinated C1-C6-alkylsulfanyl) is a radical of the formula R—S—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise fluoromethylthio, difluoromethylthio, trifluoromethylthio, (R)-1-fluoroethylthio, (S)-1-fluoroethylthio, 2-fluoroethylthio, 1,1-difluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, (R)-1-fluoropropylthio, (S)-1-fluoropropylthio, 2-fluoropropylthio, 3-fluoropropylthio, 1,1-difluoropropylthio, 2,2-difluoropropylthio, 3,3-difluoropropylthio, 3,3,3-trifluoropropylthio, (R)-2-fluoro-1-methylethylthio, (S)-2-fluoro-1-methylethylthio, (R)-2,2-difluoro-1-methylethylthio, (S)-2,2-difluoro-1-methylethylthio, (R)-1,2-difluoro-1-methylethylthio, (S)-1,2-difluoro-1-methylethylthio, (R)-2,2,2-trifluoro-1-methylethylthio, (S)-2,2,2-trifluoro-1-methylethylthio, 2-fluoro-1-(fluoromethyl)ethylthio, 1-(difluoromethyl)-2,2-difluoroethylthio, (R)-1-fluorobutylthio, (S)-1-fluorobutylthio, 2-fluorobutylthio, 3-fluorobutylthio, 4-fluorobutylthio, 1,1-difluorobutylthio, 2,2-difluorobutylthio, 3,3-difluorobutylthio, 4,4-difluorobutylthio, 4,4,4-trifluorobutylthio, etc.
Fluorinated C1-C6 alkylsulfinyl is a radical of the formula R—S(O)—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise fluoromethylsulfinyl, difluoromethylsulfinyl, trifluoromethylsulfinyl, (R)-1-fluoroethylsulfinyl, (S)-1-fluoroethylsulfinyl, 2-fluoroethylsulfinyl, 1,1-difluoroethylsulfinyl, 2,2-difluoroethylsulfinyl, 2,2,2-trifluoroethylsulfinyl, (R)-1-fluoropropylsulfinyl, (S)-1-fluoropropylsulfinyl, 2-fluoropropylsulfinyl, 3-fluoropropylsulfinyl, 1,1-difluoropropylsulfinyl, 2,2-difluoropropylsulfinyl, 3,3-difluoropropylsulfinyl, 3,3,3-trifluoropropylsulfinyl, (R)-2-fluoro-1-methylethylsulfinyl, (S)-2-fluoro-1-methylethylsulfinyl, (R)-2,2-difluoro-1-methylethylsulfinyl, (S)-2,2-difluoro-1-methylethylsulfinyl, (R)-1,2-difluoro-1-methylethylsulfinyl, (S)-1,2-difluoro-1-methylethylsulfinyl, (R)-2,2,2-trifluoro-1-methylethylsulfinyl, (S)-2,2,2-trifluoro-1-methylethylsulfinyl, 2-fluoro-1-(fluoromethyl)ethylsulfinyl, 1-(difluoromethyl)-2,2-difluoroethylsulfinyl, (R)-1-fluorobutylsulfinyl, (S)-1-fluorobutylsulfinyl, 2-fluorobutylsulfinyl, 3-fluorobutylsulfinyl, 4-fluorobutylsulfinyl, 1,1-difluorobutylsulfinyl, 2,2-difluorobutylsulfinyl, 3,3-difluorobutylsulfinyl, 4,4-difluorobutylsulfinyl, 4,4,4-trifluorobutylsulfinyl, etc.
Fluorinated C1-C6 alkylsulfonyl is a radical of the formula R—S(O)2—, wherein R is a fluorinated alkyl radical having from 1 to 6 carbon atoms as defined above. Examples comprise fluoroethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, (R)-1-fluoroethylsulfonyl, (S)-1-fluoroethylsulfonyl, 2-fluoroethylsulfonyl, 1,1-difluoroethylsulfonyl, 2,2-difluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, (R)-1-fluoropropylsulfonyl, (S)-1-fluoropropylsulfonyl, 2-fluoropropylsulfonyl, 3-fluoropropylsulfonyl, 1,1-difluoropropylsulfonyl, 2,2-difluoropropylsulfonyl, 3,3-difluoropropylsulfonyl, 3,3,3-trifluoropropylsulfonyl, (R)-2-fluoro-1-methylethylsulfonyl, (S)-2-fluoro-1-methylethylsulfonyl, (R)-2,2-difluoro-1-methylethylsulfonyl, (S)-2,2-difluoro-1-methylethylsulfonyl, (R)-1,2-difluoro-1-methylethylsulfonyl, (S)-1,2-difluoro-1-methylethylsulfonyl, (R)-2,2,2-trifluoro-1-methylethylsulfonyl, (S)-2,2,2-trifluoro-1-methylethylsulfonyl, 2-fluoro-1-(fluoromethyl)ethylsulfonyl, 1-(difluoromethyl)-2,2-difluoroethylsulfonyl, (R)-1-fluorobutylsulfonyl, (S)-1-fluorobutylsulfonyl, 2-fluorobutylsulfonyl, 3-fluorobutylsulfonyl, 4-fluorobutylsulfonyl, 1,1-difluorobutylsulfonyl, 2,2-difluorobutylsulfonyl, 3,3-difluorobutylsulfonyl, 4,4-difluorobutylsulfonyl, 4,4,4-trifluorobutylsulfonyl, etc.
C3-C6 Cycloalkyl is a cycloaliphatic radical having from 3 to 6 C atoms, such as cyclopropyl, cyclobutyl and cyclopentyl. The cycloalkyl radical may be unsubstituted or may carry 1, 2, 3 or 4 C1-C4 alkyl radicals, preferably a methyl radical. One alkyl radical is preferably located in the 1-position of the cycloalkyl radical, such as in 1-methylcyclopropyl or 1-methylcyclobutyl.
Fluorinated C3-C6 cycloalkyl is a cycloaliphatic radical having from 3 to 6 C atoms, such as cyclopropyl, cyclobutyl and cyclopentyl, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by a fluorine atoms such as in 1-fluorocyclopropyl, 2-fluorocyclopropyl, 2,2-difluorocyclopropyl, 1,2-difluorocyclopropyl, 2,3-difluorocyclopropyl, pentafluorocyclopropyl, 1-fluorocyclobutyl, 2-fluorocyclobutyl, 3-fluorocyclobutyl, 2,2-difluorocyclobutyl, 3,3-difluorocyclobutyl, 1,2-difluorocyclobutyl, 1,3-difluorocyclobutyl, 2,3-difluorocyclobutyl, 2,4-difluorocyclobutyl, or 1,2,2-trifluorocyclobutyl.
C2-C6-Alkenyl is a singly unsaturated hydrocarbon radical having 2, 3, 4, 5 or 6 C-atoms, e.g. vinyl, allyl(2-propen-1-yl), 1-propen-1-yl, 2-propen-2-yl, methallyl(2-methylprop-2-en-1-yl) and the like. C3-C4-Alkenyl is, in particular, allyl, 1-methylprop-2-en-1-yl, 2-buten-1-yl, 3-buten-1-yl, methallyl, 2-penten-1-yl, 3-penten-1-yl, 4-penten-1-yl, 1-methylbut-2-en-1-yl or 2-ethylprop-2-en-1-yl.
Fluorinated C2-C6-alkenyl is a singly unsaturated hydrocarbon radical having 2, 3, 4, 5 or 6 C-atoms, I, wherein at least one, e.g. 1, 2, 3, 4 or all of the hydrogen atoms are replaced by a fluorine atoms such as in 1-fluorovinyl, 2-fluorovinyl, 2,2-fluorovinyl, 3,3,3-fluoropropenyl, 1,1-difluoro-2-propenyl 1-fluoro-2-propenyl etc.
3- to 7-membered heterocyclic radicals comprise saturated heterocyclic radicals, which generally have 3-, 4-, 5-, 6- or 7 ring-forming atoms (ring members), unsaturated non-aromatic heterocyclic radicals, which generally have 5-, 6- or 7 ring forming atoms, and heteroaromatic radicals, which generally have 5-, 6- or 7 ring forming atoms. The heterocylcic radicals may be bound via a carbon atom (C-bound) or an nitrogen atom (N-bound). Preferred heterocyclic radicals comprise 1 nitrogen atom as ring member atom and optionally 1, 2 or 3 further heteroatoms as ring members, which are selected, independently of each other from O, S and N. Likewise preferred heterocyclic radicals comprise 1 heteroatom as ring member, which is selected from O, S and N, and optionally 1, 2 or 3 further nitrogen atoms as ring members. The heterocyclic radicals may also comprise 1 to 3 heteroatom-containing groups as ring members, like CO, SO and SO2. Examples therefore are the below-mentioned oxo-containing heterocycles.
Examples of 3- to 7-membered, saturated heterocyclic radicals comprise 1- or 2-aziridinyl, 1-, 2- or 3-azetidinyl, 1-, 2- or 3-pyrrolidinyl, 2- or 3-oxopyrrolidinyl, 1-, 2-, 3- or 4-piperidinyl, 2-, 3- or 4-morpholinyl, 2-, 3- or 4-thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl, 1-, 2- or 3-piperazinyl, 2-, 3-4- or 5-oxazolidinyl, 2-, 4- or 5-oxo-oxazolidinyl, 2-, 3-, 4- or 5-isoxazolidinyl, 2-oxiranyl, 2- or 3-oxetanyl, 2- or 3-oxolanyl, 2-, 3- or 4-oxanyl, 1,3-dioxolan-2- or 4-yl and the like, which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra and/or hydroxy.
Unsaturated non-aromatic heterocyclic radicals are heterocyclic radicals which generally have 5-, 6- or 7 ring-forming atoms and which have 1 or 2 double bonds that do not form an aromatic π-electron system. Examples are 2,3-dihydropyrrolyl, 3,4-dihydropyrrolyl, 2,3-dihydrofuranyl, 3,4-dihydrofuranyl, 2,3-dihydrothiophenyl, 3,4-dihydrothiophenyl, 1,2-dihydropyridinyl, 2,3-Dihydropyridinyl, 3,4-dihydropyridinyl, 1,2,3,4-tetrahydropyridinyl, 2,3,4,5-tetrahydropyridinyl, and the like.
5- or 6-membered heteroaromatic radicals are heteroaromatic cyclic radicals, wherein the cyclic radical has 5 or 6 atoms which form the ring (ring members) and wherein generally 1, 2, 3 or 4 ring member atoms are selected from O, S and N, the other ring member atoms being carbon atoms. The heteroaromatic radicals may be bound via a carbon atom (C-bound) or an nitrogen atom (N-bound). Preferred heteroaromatic radicals comprise 1 nitrogen atom as ring member atom and optionally 1, 2 or 3 further heteroatoms as ring members, which are selected, independently of each other from O, S and N. Likewise preferred heteroaromatic radicals comprise 1 heteroatom as ring member, which is selected from O, S and N, and optionally 1, 2 or 3 further nitrogen atoms as ring members. Examples of 5- or 6-membered heteroaromatic radicals comprise 2-, 3-, or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl, 3- or 4-pyridazinyl, 2- or 3-thienyl, 2- or 3-furyl, 1-, 2- or 3-pyrrolyl, 1-, 2- or 4-imidazolyl, 1-, 3- or 4-pyrazolyl, 1- or 3-[1,2,4]-triazolyl, 1- or 4-[1,2,3]-triazolyl, 1-, 2- or 5-tetrazolyl, 2-, 3- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 3- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 4- or 5-[1,2,3]-oxadiazolyl, [1,2,5]-oxadiazolyl(=furazanyl), 3- or 5-[1,2,4]-oxadizolyl, [1,3,4]-oxadizolyl, 4- or 5-[1,2,3]-thiadiazolyl, [1,2,5]-thiadiazolyl, 3- or 5-[1,2,4]-thiadizolyl or [1,3,4]-thiadiazolyl, which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra and/or hydroxy.
Examples of a phenyl ring fused to a saturated or unsaturated 5- or 6-membered carbocyclic or heterocyclic ring comprise indenyl, indanyl, naphthyl, 1,2- or 2,3-dihydronaphthyl, tetralin, benzofuranyl, 2,3-dihydrobenzofuranyl, benzothienyl, indolyl, indazolyl, benzimidazolyl, benzoxathiazolyl, benzoxadiazolyl, benzothiadiazolyl, benzoxazinyl, dihydrobenzoxazinyl, chinolinyl, isochinolinyl, tetrahydroisochinolinyl, chromenyl, chromanyl and the like, which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra. This fused system may be bonded to the remainder of the molecule (more precisely to the sulfonyl group) via carbon atoms of the phenyl moiety or via ring atoms (C- or N-atoms) of the ring fused to phenyl.
If R6 and R7 form together with N a 4-, 5- or 6-membered ring, examples for this type of radical comprise, apart from the above-defined 5- or 6-membered heteroaromatic radicals containing at least one N atom as ring member, the N-atom further being bound to Ar (like in pyrrol-1-yl, pyrazol-1-yl, imidazol-1-yl, [1,2,3]-triazol-1-yl and the like), azetidinyl, azetinyl, pyrrolinyl, pyrrolidinyl, pyrazolinyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, oxazolinyl, oxazolidinyl, piperidinyl, piperazinyl, morpholinyl and the like.
A skilled person will appreciate that the radical -E-SO2-Ar may be bound to any of the carbon atoms of the phenyl part of the bicyclic moiety in formula I, thereby substituting a hydrogen atom. Specifically, the radical -E-SO2—Ar is bound to a carbon atom, which is not adjacent to a bridgehead carbon atom of the bicyclic moiety. A skilled person will further appreciate that for Y being CHR2aCH2 or CHR2aCH2CH2 the CHR2a moiety is attached to the carbon atom that carries the CH2NR1R1a radical. Similarly, for X being CHR2CH2 the CHR2 moiety is attached to the carbon atom that carries the CH2NR1R1a radical. A skilled person will also appreciate that for X being N or C—R2 the  indicates a double bond while for X being N—R2, CHR2 or CHR2CH2 the  indicates a single bond. A skilled person will also appreciate that for X being absent, i.e. a covalent bond, the carbon atom, to which CH2—NR1R1a is bound, is linked to the benzene ring via a covalent (single) bond.
In a specific embodiment, the compounds of the invention are compounds of formula (I.1)




wherein

    
    
        Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, comprising 1 nitrogen atom as ring member and 0, 1, 2 or 3 further heteroatoms, independently of each other, selected from O, S and N, as ring members, wherein Ar may carry 1, 2 or 3 radicals Ra which are, independently of each other, selected from the group consisting of halogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, fluorinated C1-C6-alkyl, fluorinated C3-C6-cycloalkyl, fluorinated C1-C6-alkoxy, NR4R5, 1-aziridinyl, azetidin-1-yl, pyrrolidin-1-yl or piperidin-1-yl, wherein the last four mentioned radicals may be fluorinated, a phenyl group and an aromatic 5- or 6-membered C-bound heteroaromatic radical, comprising 1 nitrogen atom as ring member and 0, 1, 2 or 3 further heteroatoms, independently of each other, selected from O, S and N, wherein the last two mentioned radicals may carry 1, 2, 3 or 4 radicals selected from Halogen and the radicals Ra;
        R4, R5 independently of each other are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl;
        and X, Y,  E, R1, R1a, R2, R2a and R3 are as defined above.
    
    


Preferably, Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, comprising 1 nitrogen atom as ring member and 0, 1, 2 or 3 further heteroatoms, independently of each other, selected from O, S and N, as ring members which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra and/or Rb. Amongst these heteroaromatic radicals those are preferred, which comprise 1, 2 or 3 nitrogen atoms and no further heteroatom as ring members, or 1 or 2 nitrogen atoms and 1 atom, selected from 0 and S, as ring members. However, thienyl and furyl are likewise preferred. Particularly preferred radicals Ar are 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, 2-, 3- or 5-thiazolyl, 1,2,4-triazol-3-yl, 1,2,3-triazol-4-yl, 1,3,4-thiadiazol-2-yl, in particular 2-thienyl, 2-pyrimidinyl, 5-pyrimidinyl, 2-pyridinyl and more particularly phenyl which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra.
Preferred radicals Ar are phenyl, 2- or 3-thienyl, 2-, 3- or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, 2-, 3-or 5-thiazolyl, 1,2,4-triazol-3-yl, 1,2,3-triazol-4-yl, 1,3,4-thiadiazol-2-yl, in particular phenyl, 2-thienyl, 2-pyrimidinyl, 5-pyrimidinyl, 2-pyridinyl and more particularly phenyl.
Preferably the aromatic radical Ar carries one radical Ra and optionally one or two further radicals Rb selected from CN, OH, methyl, fluorinated methyl, halogen, in particular fluorine or chlorine.
The aforementioned 5-membered heteroaromatic radicals Ar carry preferably one radical Ra in the 3-position (related to the position of the SO2-radical) and optionally one or two further radicals Rb, which are preferably selected from halogen, in particular fluorine or chlorine.
Phenyl and the aforementioned 6-membered heteroaromatic radicals Ar preferably carry one radical Ra in the 4-position (related to the position of the SO2-radical) and optionally one or two further radicals Rb, which are preferably selected from halogen, in particular fluorine or chlorine.
In one preferred embodiment of the invention Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring and optionally 1 or 2 further radicals Rb, which are preferably selected from halogen, in particular from fluorine or chlorine. More preferably, Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring and no further radical.
In another preferred embodiment of the invention Ar is 2-pyrimidinyl that carries a radical Ra in the 5-position of the pyrimidine ring and optionally 1 or 2 further radicals Rb, which are preferably selected from halogen, in particular from fluorine or chlorine.
In another preferred embodiment of the invention Ar is 5-pyrimidinyl that carries a radical Ra in the 2-position of the pyrimidine ring and optionally 1 or 2 further radicals Rb, which are preferably selected from halogen, in particular from fluorine or chlorine.
In another preferred embodiment of the invention Ar is 2-thienyl that carries a radical Ra in the 3-position of the thiophene ring and optionally 1 or 2 further radicals Rb, which are preferably selected from halogen, in particular from fluorine or chlorine.
In another preferred embodiment of the invention, Ar is phenyl, which is fused to a 5-or 6-membered heterocyclic or carbocylic ring as described above and which is unsubstituted or which may carry 1, 2 or 3 radicals Ra as given above. Preferably, this fused system is selected from indenyl, indanyl, naphthyl, tetralin, benzofuranyl, 2,3-dihydrobenzofuranyl, benzothienyl, indolyl, indazolyl, benzimidazolyl, benzoxathiazolyl, benzoxadiazolyl, benzothiadiazolyl, benzoxazinyl, dihydrobenzoxazinyl, chinolinyl, isochinolinyl, tetrahydroisochinolinyl, chromenyl, chromanyl and the like, which may be unsubstituted or which may carry 1, 2 or 3 of the aforementioned radicals Ra. Preferred substituents Ra for this fused system are selected from halogen, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkoxy, fluorinated C1-C4-alkoxy, C1-C4-alkylcarbonyl and fluorinated C1-C4-alkylcarbonyl. More preferred substituents Ra for this fused system are selected from halogen, C1-C4-alkyl and fluorinated C1-C4-alkylcarbonyl.
In a more preferred embodiment of the invention, Ar is phenyl. Preferably, Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring and optionally 1 or 2 further radicals Rb, which are preferably selected from halogen, in particular from fluorine or chlorine. More preferably, Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring and no further radical.
In one preferred embodiment, the radical Ar carries one radical Ra, which has the formula Ra′.




wherein

    
    
        Y is N, CH or CF,
        Ra1 and Ra2 are independently of each other selected from C1-C2-alkyl, in particular methyl, fluorinated C1-C2-alkyl, in particular fluoromethyl, difluoromethyl or trifluoromethyl, provided for Y being CH or CF one of the radicals Ra1 or Ra2 may also be hydrogen or fluorine, or
        Ra1 and Ra2 form a radical (CH2)m wherein 1 or 2 of the hydrogen atoms may be replaced by fluorine, hydroxy, oxo, C1-C2-alkyl or C1-C2-alkoxy, wherein one CH2 moiety may be replaced by O, S, S═O, SO2 or N—Rc, Rc being hydrogen or C1-C2-alkyl and wherein m is 2, 3, 4, 5 or 6, preferably 2, 3 or 4, in particular CH2—CH2, CHF—CH2 CF2—CH2, CH2—CH2—CH2, CHF—CH2—CH2, CF2—CH2—CH2, CH2—CHF—CH2, CH2—CF2—CH2.
    
    


In case Ra1 and Ra2 form a radical (CH2)m it is preferred that 1 or 2 of the hydrogen atoms may be replaced by fluorine. Examples therefore are CH2—CH2, CHF—CH2—CF2—CH2, CH2—CH2—CH2, CHF—CH2—CH2, CF2—CH2—CH2, CH2—CHF—CH2, and CH2—CF2—CH2.
In case Ra1 and Ra2 are different from each other, the radical of the aforementioned formula Ra may have either (R)- or (S)-configuration with regard to the Y-moiety.
Examples for preferred radicals of the formula Ra′ comprise isopropyl, (R)-1-fluoroethyl, (S)-1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (R)-1-fluoropropyl, (S)-1-fluoropropyl, (R)-2-fluoropropyl, (S)-2-fluoropropyl, 3-fluoropropyl, 1,1-difluoropropyl, 2,2-difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl, 1-(difluoromethyl)-2,2-difluoroethyl, cyclopropyl, cyclobutyl, 1-fluorocyclopropyl, (R)- and (S)-2,2-difluorocyclopropyl, (R)- and (S)-2-fluorocyclopropyl.
Amongst the radicals of the formula Ra′ those are preferred which carry 1, 2, 3 or 4, in particular 1, 2 or 3 fluorine atoms.
Examples for alternatively preferred radicals of the formula Ra′ comprise 4-morpholinyl, 4-thiomorpholinyl, 4-(1,1-dioxo)thiomorpholinyl, piperazin-1-yl, 4-methylpiperazin-1-yl, azetidin-1-yl, 2-methylazetidin-1-yl, (S)-2-methylazetidin-1-yl, (R)-2-methylazetidin-1-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, 3-hydroxyazetidin-1-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, (S)-pyrrolidin-2-yl, (R)-pyrrolidin-2-yl, pyrrolidin-3-yl, (S)-pyrrolidin-3-yl, (R)-pyrrolidin-3-yl, 2-fluoropyrrolidin-1-yl, (S)-2-fluoropyrrolidin-1-yl, (R)-2-fluoropyrrolidin-1-yl, 3-fluoropyrrolidin-1-yl, (S)-3-fluoropyrrolidin-1-yl, (R)-3-fluoropyrrolidin-1-yl, 2,2-difluoropyrrolidin-1-yl, 3,3-difluoropyrrolidin-1-yl, 2-methylpyrrolidin-1-yl, (S)-2-methylpyrrolidin-1-yl, (R)-2-methylpyrrolidin-1-yl, 3-methylpyrrolidin-1-yl, (S)-3-methylpyrrolidin-1-yl, (R)-3-methylpyrrolidin-1-yl, 1-methylpyrrolidin-2-yl, (S)-1-methylpyrrolidin-2-yl, (R)-1-methylpyrrolidin-2-yl, 1-methylpyrrolidin-3-yl, (S)-1-methylpyrrolidin-3-yl, (R)-1-methylpyrrolidin-3-yl, 2,2-dimethylpyrrolidin-1-yl, 3,3-dimethylpyrrolidin-1-yl, 2-trifluoromethylpyrrolidin-1-yl, (S)-2-trifluoromethylpyrrolidin-1-yl, (R)-2-trifluoromethylpyrrolidin-1-yl, 3-trifluoromethylpyrrolidin-1-yl, (S)-3-trifluoromethylpyrrolidin-1-yl, (R)-3-trifluoromethylpyrrolidin-1-yl, 2-oxopyrrolidin-1-yl, 2-oxooxazolidin-3-yl, piperidin-1-yl, 2-methylpiperidin-1-yl, (S)-2-methylpiperidin-1-yl and (R)-2-methylpiperidin-1-yl.
More preferably, Ra′ is selected from isopropyl and fluorinated isopropyl, like (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl and 1-(difluoromethyl)-2,2-difluoroethyl.
In another preferred embodiment Ar carries one radical Ra, which is selected from 5- or 6-membered heteroaromatic radicals having as ring members 1 heteroatom selected from O, S and N and which may further have 1, 2 or 3 nitrogen atoms as ring members, and wherein the 5- or 6-membered heteroaromatic radical may carry 1, 2 or 3 substituents selected from halogen, NO2, NH2, OH, CN, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, fluorinated C1-C6-alkyl, fluorinated C3-C6-cycloalkyl, fluorinated C1-C6-alkoxy, C1-C6-hydroxyalkyl, C1-C4-alkoxy-C2-C4-alkyl, C1-C6-hydroxyalkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C6-alkylcarbonyl, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, fluorinated C1-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, fluorinated C1-C6-alkylsulfinyl and fluorinated C1-C6-alkylsulfonyl. Amongst these radicals Ra, preference is given to radicals selected from 2-, 3-, or 4-pyridyl, 2-, 4- or 5-pyrimidinyl, pyrazinyl, 3- or 4-pyridazinyl, 2- or 3-thienyl, 2- or 3-furyl, 1-, 2- or 3-pyrrolyl, 1-, 2- or 4-imidazolyl, 1-, 3- or 4-pyrazolyl, 1- or 3-[1,2,4]-triazolyl, 1- or 4-[1,2,3]-triazolyl, 1-, 2- or 5-tetrazolyl, 2-, 3- or 5-oxazolyl, 3-, 4- or 5-isoxazolyl, 2-, 3- or 5-thiazolyl, 3-, 4- or 5-isothiazolyl, 4- or 5-[1,2,3]-oxadiazolyl, [1,2,5]-oxadiazolyl(=furazanyl), 3- or 5-[1,2,4]-oxadizolyl, [1,3,4]-oxadizolyl, 4- or 5-[1,2,3]-thiadiazolyl, [1,2,5]-thiadiazolyl, 3- or 5-[1,2,4]-thiadizolyl or [1,3,4]-thiadiazolyl, in particular from 2- or 3-furanyl, 2- or 3-thienyl, 1-, 2- or 3-pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, 1,3,4-thiadiazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl and tetrazolyl, where the heteroaromatic radical may be unsubstituted or may carry 1 to 3 substituents as given above. Preferred substituents on heteroaromatic Ra are selected from halogen, C1-C4-alkyl, C1-C4-alkoxy, fluorinated C1-C4-alkyl and fluorinated C1-C4-alkoxy.
In another preferred embodiment of the invention, Ar carries 1 radical Ra which selected from the group consisting of C1-C6-alkenyl, fluorinated C1-C6-alkenyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C4-alkyl, C1-C6-hydroxyalkoxy, C1-C6-alkoxy-C1-C4-alkoxy, COOH, CH2NR4R5, ONR4R5, NHC(O)NR4R5, C(O)NR4R5, SO2NR4R5, C1-C6-alkylcarbonyl, fluorinated C2-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, fluorinated C1-C6-alkylsulfinyl, fluorinated C1-C6-alkylsulfonyl, phenylsulfonyl, phenoxy, benzyloxy and a 5-or 6-membered N-bound heteroaromatic radical, wherein the four last mentioned radicals may carry 1, 2, 3 or 4 radicals selected from halogen, NO2, —NH2, OH, CN, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, fluorinated C1-C6-alkyl, fluorinated C3-C6-cycloalkyl, fluorinated C1-C6-alkoxy, C1-C6-hydroxyalkyl, C1-C4-alkoxy-C2-C4-alkyl, C1-C6-hydroxyalkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C6-alkylcarbonyl, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, fluorinated C1-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfonyl, fluorinated C1-C6-alkylsulfinyl and fluorinated C1-C6-alkylsulfonyl.
In another preferred embodiment, Ar carries 1 radical Ra which selected from fluorinated C1-C4-alkoxy, more preferably from fluorinated C1-C2-alkoxy and in particular from OCH2F, OCHF2 and OCF3.
In a more preferred embodiment of the invention, Ar carries 1 radical Ra which selected from a radical of the formula Ra′, in particular isopropyl or fluorinated isopropyl like (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl and 1-(difluoromethyl)-2,2-difluoroethyl, and fluorinated C1-C4-alkoxy, in particular OCH2F, OCHF2 and OCF3.
In a very preferred embodiment, Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring, where Ra is selected from a radical of the formula Ra′, in particular isopropyl or fluorinated isopropyl like (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl and 1-(difluoromethyl)-2,2-difluoroethyl, and fluorinated C1-C4-alkoxy, in particular OCH2F, OCHF2 and OCF3. Particularly, Ar does not carry any radical Rb.
The radical R1 is preferably different from hydrogen, in particular C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C2-C4-alkyl, fluorinated C3-C4-cycloalkyl or fluorinated C3-C4-alkenyl, more preferably n-propyl, fluorinated C2-C3-alkyl or 1-propen-3-yl(allyl), most preferably propyl or 1-propen-3-yl.
Preferably the moiety E is N—R3 wherein R3 is as defined above. R3 is in particular H or methyl and most preferred H.
One preferred embodiment of the invention relates to compounds of the formula I, wherein R1a is hydrogen.
Another embodiment of the invention relates to compounds of the formula I, wherein R1a is C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C2-C4-alkyl, fluorinated C3-C4-cycloalkyl or fluorinated C3-C4-alkenyl, in particular n-propyl, fluorinated C2-C3-alkyl or 1-propen-3-yl, more particularly propyl or 1-propen-3-yl.
The radicals R2 and R2a are preferably methyl, fluorinated methyl or hydrogen, in particular hydrogen.
Together with the benzene ring, the moiety XC(R)—Y (R is CH2NR1R1a) forms a bicyclic moiety. The fused ring, which is formed by the moiety XC(R)—Y, is preferably a 5- or 6-membered ring.
In one embodiment of the invention, the moiety XC(R)—Y (R is CH2NR1R1a) forms a fused carbocyclic moiety, i.e. neither X nor Y comprise a heteroatom as ring member. Preferably the fused carbocyclic moiety is a 5- or 6-membered ring.
In this embodiment X is preferably CHR2 and in particular CH2. In this embodiment Y is preferably CHR2a or CHR2aCH2, in particular CH2 or CH2CH2. In this embodiment, X may also be absent, i.e. X depicts a single bond, which connects the CR-moiety with the carbon atom of the fused benzene ring. Y is then preferably CHR2aCH2 or CHR2aCH2CH2, in particular CH2CH2 or CH2CH2CH2.
In another embodiment of the invention, the moiety XC(R)—Y (R is CH2NR1R1a) forms a fused heterocyclic moiety, i.e. X and/or Y comprise a nitrogen atom as ring member. Preferably the fused heterocyclic moiety is a 5- or 6-membered ring.
This embodiment X relates in particular to compounds I, wherein X is CHR2 and in particular CH2. while Y is N—R2, in particular NH. This embodiment also relates to compounds wherein X is N or CR2 and in particular N or CH. while Y is N—R2, in particular NH.
Although it is generally preferred that R2 and R2a are hydrogen, it may also be preferred that R1a and R2 or R1a and R2a, if present, together form a moiety (CH2)n, wherein n is as defined above and in particular 1 or 2. Thereby an additional fused ring is formed, which may be transfused or cis-fused. In particular, this embodiment relates to compounds of the general formula I, wherein X is CR2, CHR2 or CHR2CH2 and R1a and R2 together are (CH2)n with n being 1, 2 or 3, more preferably 1 or 2. Amongst these compounds, those are preferred, wherein Y is NR2a, CH2 or CH2CH2. This embodiment also relates to compounds of the general formula I, wherein Y is CHR2a, CHR2aCH2 or CHR2aCH2CH2 and R1a and R2a together are (CH2)n with n being 1, 2 or 3, more preferably 1 or 2. Amongst these compounds, those are preferred, wherein X is NR2, CH2 or CH2CH2. This embodiment also relates to compounds of the general formula I, wherein X a covalent bond and Y is CHR2aCH2CH2 and R1a and R2a together are (CH2)n with n being 1, 2 or 3, more preferably 1. Alternatively, this embodiment relates to compounds of the general formula I, wherein X CH2CH2 and Y is CHR2a and R1a and R2a together are (CH2)n with n being 1, 2 or 3, more preferably 1. Preferred examples for these tricyclic systems are compounds of the following formulae:




Preferably, R4 and R5 are independently H, C1-C4-alkyl or C1-C4-alkoxy.
Preferably, R6 and R7 are both hydrogen or both halogen, more preferably both hydrogen or both chlorine. In case there is no tricyclic system as described above, i.e. R1a and R2a or R1a and R2 do not form an alkylene bridge (CH2)m, it is preferred that R6 and R7 are both hydrogen.
Particularly preferred compounds I are those of formulae I.a, I.b, I.c, I.d, I.e, I.f, I.g, I.h and I.i, wherein R1 and Ar have the above-defined meanings. Preferred meanings of R1 and Ar are as defined above.




Examples of preferred compounds which are represented by the formulae I.a, I.b, I.c, I.d, I.e, I.f, I.g, I.h and I.i are the individual compounds I.a, I.b, I.c, I.d, I.e, I.f, I.g, I.h and I.i compiled above, where the variables Ar and R1 have the meanings given in one row of table A:









TABLE A





No.
R1
Ar

















1.
propyl
4-methylphenyl


2.
propyl
4-ethylphenyl


3.
propyl
4-propylphenyl


4.
propyl
4-isopropylphenyl


5.
propyl
4-sec-butylphenyl


6.
propyl
4-isobutylphenyl


7.
propyl
4-(1,1-dimethylpropyl)-phenyl


8.
propyl
4-vinylphenyl


9.
propyl
4-isopropenylphenyl


10.
propyl
4-fluorophenyl


11.
propyl
4-chlorophenyl


12.
propyl
4-bromophenyl


13.
propyl
4-(fluoromethyl)phenyl


14.
propyl
3-(fluoromethyl)phenyl


15.
propyl
2-(fluoromethyl)phenyl


16.
propyl
4-(difluoromethyl)phenyl


17.
propyl
3-(difluoromethyl)phenyl


18.
propyl
2-(difluoromethyl)phenyl


19.
propyl
4-(trifluoromethyl)phenyl


20.
propyl
3-(trifluoromethyl)phenyl


21.
propyl
2-(trifluoromethyl)phenyl


22.
propyl
4-(1-fluoroethyl)-phenyl


23.
propyl
4-((S)-1-fluoroethyl)-phenyl


24.
propyl
4-((R)-1-fluoroethyl)-phenyl


25.
propyl
4-(2-fluoroethyl)-phenyl


26.
propyl
4-(1,1-difluoroethyl)-phenyl


27.
propyl
4-(2,2-difluoroethyl)-phenyl


28.
propyl
4-(2,2,2-trifluoroethyl)-phenyl


29.
propyl
4-(3-fluoropropyl)-phenyl


30.
propyl
4-(2-fluoropropyl)-phenyl


31.
propyl
4-((S)-2-fluoropropyl)-phenyl


32.
propyl
4-((R)-2-fluoropropyl)-phenyl


33.
propyl
4-(3,3-difluoropropyl)-phenyl


34.
propyl
4-(3,3,3-trifluoropropyl)-phenyl


35.
propyl
4-(1-fluoro-1-methylethyl)-phenyl


36.
propyl
4-(2-fluoro-1-methylethyl)-phenyl


37.
propyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


38.
propyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


39.
propyl
4-(2,2-difluoro-1-methylethyl)-phenyl


40.
propyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


41.
propyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


42.
propyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


43.
propyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


44.
propyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


45.
propyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


46.
propyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


47.
propyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


48.
propyl
4-methoxyphenyl


49.
propyl
4-ethoxyphenyl


50.
propyl
4-propoxyphenyl


51.
propyl
4-isopropoxyphenyl


52.
propyl
4-butoxyphenyl


53.
propyl
4-(fluoromethoxy)-phenyl


54.
propyl
4-(difluoromethoxy)-phenyl


55.
propyl
4-(trifluoromethoxy)-phenyl


56.
propyl
3-(trifluoromethoxy)-phenyl


57.
propyl
4-(2-fluoroethoxy)-phenyl


58.
propyl
4-(2,2-difluoroethoxy)-phenyl


59.
propyl
4-(2,2,2-trifluoroethoxy)-phenyl


60.
propyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


61.
propyl
4-cyclopropylphenyl


62.
propyl
4-cyclobutylphenyl


63.
propyl
4-cyclopentylphenyl


64.
propyl
4-(2,2-difluorocyclopropyl)-phenyl


65.
propyl
3,4-difluorophenyl


66.
propyl
4-bromo-3-fluorophenyl


67.
propyl
4-bromo-2-fluorophenyl


68.
propyl
4-bromo-2,5-difluorophenyl


69.
propyl
2-fluoro-4-isopropylphenyl


70.
propyl
3-fluoro-4-isopropylphenyl


71.
propyl
4-(1-hydroxy-1-methylethyl)-phenyl


72.
propyl
4-(2-hydroxy-2-methylpropyl)-phenyl


73.
propyl
4-acetylphenyl


74.
propyl
4-carboxyphenyl


75.
propyl
4-cyanophenyl


76.
propyl
4-hydroxyphenyl


77.
propyl
4-(O-benzyl)-phenyl


78.
propyl
4-(2-methoxyethoxy)-phenyl


79.
propyl
4-(CH2—N(CH3)2)-phenyl


80.
propyl
4-(NH—CO—NH2)-phenyl


81.
propyl
4-(methylsulfanyl)-phenyl


82.
propyl
4-(fluoromethylsulfanyl)-phenyl


83.
propyl
4-(difluoromethylsulfanyl)-phenyl


84.
propyl
4-(trifluoromethylsulfanyl)-phenyl


85.
propyl
4-(methylsulfonyl)-phenyl


86.
propyl
4-(N-methoxy-N-methyl-amino)-phenyl


87.
propyl
4-(methoxyamino)-phenyl


88.
propyl
4-(ethoxyamino)-phenyl


89.
propyl
4-(N-methylaminooxy)-phenyl


90.
propyl
4-(N,N-dimethylaminooxy)-phenyl


91.
propyl
4-(azetidin-1-yl)-phenyl


92.
propyl
4-(2-methylazetidin-1-yl)-phenyl


93.
propyl
4-((S)-2-methylazetidin-1-yl)-phenyl


94.
propyl
4-((R)-2-methylazetidin-1-yl)-phenyl


95.
propyl
4-(3-fluoroazetidin-1-yl)-phenyl


96.
propyl
4-(3-methoxyazetidin-1-yl)-phenyl


97.
propyl
4-(3-hydroxyazetidin-1-yl)-phenyl


98.
propyl
4-(pyrrolidin-1-yl)-phenyl


99.
propyl
4-(pyrrolidin-2-yl)-phenyl


100.
propyl
4-((S)-pyrrolidin-2-yl)-phenyl


101.
propyl
4-((R)-pyrrolidin-2-yl)-phenyl


102.
propyl
4-(pyrrolidin-3-yl)-phenyl


103.
propyl
4-((S)-pyrrolidin-3-yl)-phenyl


104.
propyl
4-((R)-pyrrolidin-3-yl)-phenyl


105.
propyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


106.
propyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


107.
propyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


108.
propyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


109.
propyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


110.
propyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


111.
propyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


112.
propyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


113.
propyl
4-(2-methylpyrrolidin-1-yl)-phenyl


114.
propyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


115.
propyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


116.
propyl
4-(3-methylpyrrolidin-1-yl)-phenyl


117.
propyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


118.
propyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


119.
propyl
4-(1-methylpyrrolidin-2-yl)-phenyl


120.
propyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


121.
propyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


122.
propyl
4-(1-methylpyrrolidin-3-yl)-phenyl


123.
propyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


124.
propyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


125.
propyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


126.
propyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


127.
propyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


128.
propyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


129.
propyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


130.
propyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


131.
propyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


132.
propyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


133.
propyl
4-(2-oxopyrrolidin-1-yl)-phenyl


134.
propyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


135.
propyl
4-(piperidin-1-yl)-phenyl


136.
propyl
4-(2-methylpiperidin-1-yl)-phenyl


137.
propyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


138.
propyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


139.
propyl
4-(piperazin-1-yl)-phenyl


140.
propyl
4-(4-methylpiperazin-1-yl)-phenyl


141.
propyl
4-(morpholin-4-yl)-phenyl


142.
propyl
4-(thiomorpholin-4-yl)-phenyl


143.
propyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


144.
propyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


145.
propyl
4-(pyrrol-1-yl)-phenyl


146.
propyl
4-(pyrrol-2-yl)-phenyl


147.
propyl
4-(pyrrol-3-yl)-phenyl


148.
propyl
4-(1-methylpyrrol-2-yl)-phenyl


149.
propyl
4-(1-methylpyrrol-3-yl)-phenyl


150.
propyl
4-(furan-2-yl)-phenyl


151.
propyl
4-(furan-3-yl)-phenyl


152.
propyl
4-(thiophen-2-yl)-phenyl


153.
propyl
4-(thiophen-3-yl)-phenyl


154.
propyl
4-(5-propylthien-2-yl)-phenyl


155.
propyl
4-(pyrazol-1-yl)-phenyl


156.
propyl
4-(pyrazol-3-yl)-phenyl


157.
propyl
4-(pyrazol-4-yl)-phenyl


158.
propyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


159.
propyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


160.
propyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


161.
propyl
4-(1H-imidazol-2-yl)-phenyl


162.
propyl
4-(imidazol-1-yl)-phenyl


163.
propyl
4-(1-methylimidazol-2-yl)-phenyl


164.
propyl
4-(oxazol-2-yl)-phenyl


165.
propyl
4-(oxazol-4-yl)-phenyl


166.
propyl
4-(oxazol-5-yl)-phenyl


167.
propyl
4-(isoxazol-3-yl)-phenyl


168.
propyl
4-(isoxazol-4-yl)-phenyl


169.
propyl
4-(isoxazol-5-yl)-phenyl


170.
propyl
4-([1,2,3]-triazol-1-yl)-phenyl


171.
propyl
4-([1,2,4]-triazol-1-yl)-phenyl


172.
propyl
4-([1,2,3]-triazol-2-yl)-phenyl


173.
propyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


174.
propyl
4-([1,2,4]-triazol-4-yl)-phenyl


175.
propyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


176.
propyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


177.
propyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


178.
propyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


179.
propyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


180.
propyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


181.
propyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


182.
propyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


183.
propyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


184.
propyl
4-(1H-tetrazol-5-yl)-phenyl


185.
propyl
4-(tetrazol-1-yl)-phenyl


186.
propyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


187.
propyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


188.
propyl
4-furazan-3-yl-phenyl


189.
propyl
4-(pyrid-2-yl)-phenyl


190.
propyl
4-(pyrid-3-yl)-phenyl


191.
propyl
4-(pyrid-4-yl)-phenyl


192.
propyl
4-(pyrimidin-2-yl)-phenyl


193.
propyl
4-(pyrimidin-4-yl)-phenyl


194.
propyl
4-(pyrimidin-5-yl)-phenyl


195.
propyl
5-isopropylthiophen-2-yl


196.
propyl
2-chlorothiophen-5-yl


197.
propyl
2,5-dichlorothiophen-4-yl


198.
propyl
2,3-dichlorothiophen-5-yl


199.
propyl
2-chloro-3-nitrothiophen-5-yl


200.
propyl
2-(phenylsulfonyl)-thiophen-5-yl


201.
propyl
2-(pyridin-2-yl)thiophen-5-yl


202.
propyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


203.
propyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


204.
propyl
1-methyl-1H-imidazol-4-yl


205.
propyl
1,2-dimethyl-1H-imidazol-4-yl


206.
propyl
3,5-dimethylisoxazol-4-yl


207.
propyl
thiazol-2-yl


208.
propyl
4-methylthiazol-2-yl


209.
propyl
4-isopropylthiazol-2-yl


210.
propyl
4-trifluoromethylthiazol-2-yl


211.
propyl
5-methylthiazol-2-yl


212.
propyl
5-isopropylthiazol-2-yl


213.
propyl
5-trifluoromethylthiazol-2-yl


214.
propyl
2,4-dimethylthiazol-5-yl


215.
propyl
2-acetamido-4-methylthiazol-5-yl


216.
propyl
4H-[1,2,4]triazol-3-yl


217.
propyl
5-methyl-4H-[1,2,4]triazol-3-yl


218.
propyl
4-methyl-4H-[1,2,4]triazol-3-yl


219.
propyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


220.
propyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


221.
propyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


222.
propyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


223.
propyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


224.
propyl
[1,3,4]thiadiazol-2-yl


225.
propyl
5-methyl-[1,3,4]thiadiazol-2-yl


226.
propyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


227.
propyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


228.
propyl
3-bromo-2-chloropyrid-5-yl


229.
propyl
2-(4-morpholino)-pyrid-5-yl


230.
propyl
2-phenoxypyrid-5-yl


231.
propyl
(2-isopropyl)-pyrimidin-5-yl


232.
propyl
(5-isopropyl)-pyrimidin-2-yl


233.
propyl
8-quinolyl


234.
propyl
5-isoquinolyl


235.
propyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


236.
propyl
5-chloro-3-methylbenzothiophen-2-yl


237.
propyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


238.
propyl
benzothiazol-6-yl


239.
propyl
benzo[2,1,3]oxadiazol-4-yl


240.
propyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


241.
propyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


242.
propyl
benzo[2,1,3]thiadiazol-4-yl


243.
ethyl
4-methylphenyl


244.
ethyl
4-ethylphenyl


245.
ethyl
4-propylphenyl


246.
ethyl
4-isopropylphenyl


247.
ethyl
4-sec-butylphenyl


248.
ethyl
4-isobutylphenyl


249.
ethyl
4-(1,1-dimethylpropyl)-phenyl


250.
ethyl
4-vinylphenyl


251.
ethyl
4-isopropenylphenyl


252.
ethyl
4-fluorophenyl


253.
ethyl
4-chlorophenyl


254.
ethyl
4-bromophenyl


255.
ethyl
4-(fluoromethyl)phenyl


256.
ethyl
3-(fluoromethyl)phenyl


257.
ethyl
2-(fluoromethyl)phenyl


258.
ethyl
4-(difluoromethyl)phenyl


259.
ethyl
3-(difluoromethyl)phenyl


260.
ethyl
2-(difluoromethyl)phenyl


261.
ethyl
4-(trifluoromethyl)phenyl


262.
ethyl
3-(trifluoromethyl)phenyl


263.
ethyl
2-(trifluoromethyl)phenyl


264.
ethyl
4-(1-fluoroethyl)-phenyl


265.
ethyl
4-((S)-1-fluoroethyl)-phenyl


266.
ethyl
4-((R)-1-fluoroethyl)-phenyl


267.
ethyl
4-(2-fluoroethyl)-phenyl


268.
ethyl
4-(1,1-difluoroethyl)-phenyl


269.
ethyl
4-(2,2-difluoroethyl)-phenyl


270.
ethyl
4-(2,2,2-trifluoroethyl)-phenyl


271.
ethyl
4-(3-fluoropropyl)-phenyl


272.
ethyl
4-(2-fluoropropyl)-phenyl


273.
ethyl
4-((S)-2-fluoropropyl)-phenyl


274.
ethyl
4-((R)-2-fluoropropyl)-phenyl


275.
ethyl
4-(3,3-difluoropropyl)-phenyl


276.
ethyl
4-(3,3,3-trifluoropropyl)-phenyl


277.
ethyl
4-(1-fluoro-1-methylethyl)-phenyl


278.
ethyl
4-(2-fluoro-1-methylethyl)-phenyl


279.
ethyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


280.
ethyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


281.
ethyl
4-(2,2-difluoro-1-methylethyl)-phenyl


282.
ethyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


283.
ethyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


284.
ethyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


285.
ethyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


286.
ethyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


287.
ethyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


288.
ethyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


289.
ethyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


290.
ethyl
4-methoxyphenyl


291.
ethyl
4-ethoxyphenyl


292.
ethyl
4-propoxyphenyl


293.
ethyl
4-isopropoxyphenyl


294.
ethyl
4-butoxyphenyl


295.
ethyl
4-(fluoromethoxy)-phenyl


296.
ethyl
4-(difluoromethoxy)-phenyl


297.
ethyl
4-(trifluoromethoxy)-phenyl


298.
ethyl
3-(trifluoromethoxy)-phenyl


299.
ethyl
4-(2-fluoroethoxy)-phenyl


300.
ethyl
4-(2,2-difluoroethoxy)-phenyl


301.
ethyl
4-(2,2,2-trifluoroethoxy)-phenyl


302.
ethyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


303.
ethyl
4-cyclopropylphenyl


304.
ethyl
4-cyclobutylphenyl


305.
ethyl
4-cyclopentylphenyl


306.
ethyl
4-(2,2-difluorocyclopropyl)-phenyl


307.
ethyl
3,4-difluorophenyl


308.
ethyl
4-bromo-3-fluorophenyl


309.
ethyl
4-bromo-2-fluorophenyl


310.
ethyl
4-bromo-2,5-difluorophenyl


311.
ethyl
2-fluoro-4-isopropylphenyl


312.
ethyl
3-fluoro-4-isopropylphenyl


313.
ethyl
4-(1-hydroxy-1-methylethyl)-phenyl


314.
ethyl
4-(2-hydroxy-2-methylpropyl)-phenyl


315.
ethyl
4-acetylphenyl


316.
ethyl
4-carboxyphenyl


317.
ethyl
4-cyanophenyl


318.
ethyl
4-hydroxyphenyl


319.
ethyl
4-(O-benzyl)-phenyl


320.
ethyl
4-(2-methoxyethoxy)-phenyl


321.
ethyl
4-(CH2—N(CH3)2)-phenyl


322.
ethyl
4-(NH—CO—NH2)-phenyl


323.
ethyl
4-(methylsulfanyl)-phenyl


324.
ethyl
4-(fluoromethylsulfanyl)-phenyl


325.
ethyl
4-(difluoromethylsulfanyl)-phenyl


326.
ethyl
4-(trifluoromethylsulfanyl)-phenyl


327.
ethyl
4-(methylsulfonyl)-phenyl


328.
ethyl
4-(N-methoxy-N-methyl-amino)-phenyl


329.
ethyl
4-(methoxyamino)-phenyl


330.
ethyl
4-(ethoxyamino)-phenyl


331.
ethyl
4-(N-methylaminooxy)-phenyl


332.
ethyl
4-(N,N-dimethylaminooxy)-phenyl


333.
ethyl
4-(azetidin-1-yl)-phenyl


334.
ethyl
4-(2-methylazetidin-1-yl)-phenyl


335.
ethyl
4-((S)-2-methylazetidin-1-yl)-phenyl


336.
ethyl
4-((R)-2-methylazetidin-1-yl)-phenyl


337.
ethyl
4-(3-fluoroazetidin-1-yl)-phenyl


338.
ethyl
4-(3-methoxyazetidin-1-yl)-phenyl


339.
ethyl
4-(3-hydroxyazetidin-1-yl)-phenyl


340.
ethyl
4-(pyrrolidin-1-yl)-phenyl


341.
ethyl
4-(pyrrolidin-2-yl)-phenyl


342.
ethyl
4-((S)-pyrrolidin-2-yl)-phenyl


343.
ethyl
4-((R)-pyrrolidin-2-yl)-phenyl


344.
ethyl
4-(pyrrolidin-3-yl)-phenyl


345.
ethyl
4-((S)-pyrrolidin-3-yl)-phenyl


346.
ethyl
4-((R)-pyrrolidin-3-yl)-phenyl


347.
ethyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


348.
ethyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


349.
ethyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


350.
ethyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


351.
ethyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


352.
ethyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


353.
ethyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


354.
ethyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


355.
ethyl
4-(2-methylpyrrolidin-1-yl)-phenyl


356.
ethyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


357.
ethyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


358.
ethyl
4-(3-methylpyrrolidin-1-yl)-phenyl


359.
ethyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


360.
ethyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


361.
ethyl
4-(1-methylpyrrolidin-2-yl)-phenyl


362.
ethyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


363.
ethyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


364.
ethyl
4-(1-methylpyrrolidin-3-yl)-phenyl


365.
ethyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


366.
ethyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


367.
ethyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


368.
ethyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


369.
ethyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


370.
ethyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


371.
ethyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


372.
ethyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


373.
ethyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


374.
ethyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


375.
ethyl
4-(2-oxopyrrolidin-1-yl)-phenyl


376.
ethyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


377.
ethyl
4-(piperidin-1-yl)-phenyl


378.
ethyl
4-(2-methylpiperidin-1-yl)-phenyl


379.
ethyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


380.
ethyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


381.
ethyl
4-(piperazin-1-yl)-phenyl


382.
ethyl
4-(4-methylpiperazin-1-yl)-phenyl


383.
ethyl
4-(morpholin-4-yl)-phenyl


384.
ethyl
4-(thiomorpholin-4-yl)-phenyl


385.
ethyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


386.
ethyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


387.
ethyl
4-(pyrrol-1-yl)-phenyl


388.
ethyl
4-(pyrrol-2-yl)-phenyl


389.
ethyl
4-(pyrrol-3-yl)-phenyl


390.
ethyl
4-(1-methylpyrrol-2-yl)-phenyl


391.
ethyl
4-(1-methylpyrrol-3-yl)-phenyl


392.
ethyl
4-(furan-2-yl)-phenyl


393.
ethyl
4-(furan-3-yl)-phenyl


394.
ethyl
4-(thiophen-2-yl)-phenyl


395.
ethyl
4-(thiophen-3-yl)-phenyl


396.
ethyl
4-(5-propylthien-2-yl)-phenyl


397.
ethyl
4-(pyrazol-1-yl)-phenyl


398.
ethyl
4-(pyrazol-3-yl)-phenyl


399.
ethyl
4-(pyrazol-4-yl)-phenyl


400.
ethyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


401.
ethyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


402.
ethyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


403.
ethyl
4-(1H-imidazol-2-yl)-phenyl


404.
ethyl
4-(imidazol-1-yl)-phenyl


405.
ethyl
4-(1-methylimidazol-2-yl)-phenyl


406.
ethyl
4-(oxazol-2-yl)-phenyl


407.
ethyl
4-(oxazol-4-yl)-phenyl


408.
ethyl
4-(oxazol-5-yl)-phenyl


409.
ethyl
4-(isoxazol-3-yl)-phenyl


410.
ethyl
4-(isoxazol-4-yl)-phenyl


411.
ethyl
4-(isoxazol-5-yl)-phenyl


412.
ethyl
4-([1,2,3]-triazol-1-yl)-phenyl


413.
ethyl
4-([1,2,4]-triazol-1-yl)-phenyl


414.
ethyl
4-([1,2,3]-triazol-2-yl)-phenyl


415.
ethyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


416.
ethyl
4-([1,2,4]-triazol-4-yl)-phenyl


417.
ethyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


418.
ethyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


419.
ethyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


420.
ethyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


421.
ethyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


422.
ethyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


423.
ethyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


424.
ethyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


425.
ethyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


426.
ethyl
4-(1H-tetrazol-5-yl)-phenyl


427.
ethyl
4-(tetrazol-1-yl)-phenyl


428.
ethyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


429.
ethyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


430.
ethyl
4-furazan-3-yl-phenyl


431.
ethyl
4-(pyrid-2-yl)-phenyl


432.
ethyl
4-(pyrid-3-yl)-phenyl


433.
ethyl
4-(pyrid-4-yl)-phenyl


434.
ethyl
4-(pyrimidin-2-yl)-phenyl


435.
ethyl
4-(pyrimidin-4-yl)-phenyl


436.
ethyl
4-(pyrimidin-5-yl)-phenyl


437.
ethyl
5-isopropylthiophen-2-yl


438.
ethyl
2-chlorothiophen-5-yl


439.
ethyl
2,5-dichlorothiophen-4-yl


440.
ethyl
2,3-dichlorothiophen-5-yl


441.
ethyl
2-chloro-3-nitrothiophen-5-yl


442.
ethyl
2-(phenylsulfonyl)-thiophen-5-yl


443.
ethyl
2-(pyridin-2-yl)thiophen-5-yl


444.
ethyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


445.
ethyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


446.
ethyl
1-methyl-1H-imidazol-4-yl


447.
ethyl
1,2-dimethyl-1H-imidazol-4-yl


448.
ethyl
3,5-dimethylisoxazol-4-yl


449.
ethyl
thiazol-2-yl


450.
ethyl
4-methylthiazol-2-yl


451.
ethyl
4-isopropylthiazol-2-yl


452.
ethyl
4-trifluoromethylthiazol-2-yl


453.
ethyl
5-methylthiazol-2-yl


454.
ethyl
5-isopropylthiazol-2-yl


455.
ethyl
5-trifluoromethylthiazol-2-yl


456.
ethyl
2,4-dimethylthiazol-5-yl


457.
ethyl
2-acetamido-4-methylthiazol-5-yl


458.
ethyl
4H-[1,2,4]triazol-3-yl


459.
ethyl
5-methyl-4H-[1,2,4]triazol-3-yl


460.
ethyl
4-methyl-4H-[1,2,4]triazol-3-yl


461.
ethyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


462.
ethyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


463.
ethyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


464.
ethyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


465.
ethyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


466.
ethyl
[1,3,4]thiadiazol-2-yl


467.
ethyl
5-methyl-[1,3,4]thiadiazol-2-yl


468.
ethyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


469.
ethyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


470.
ethyl
3-bromo-2-chloropyrid-5-yl


471.
ethyl
2-(4-morpholino)-pyrid-5-yl


472.
ethyl
2-phenoxypyrid-5-yl


473.
ethyl
(2-isopropyl)-pyrimidin-5-yl


474.
ethyl
(5-isopropyl)-pyrimidin-2-yl


475.
ethyl
8-quinolyl


476.
ethyl
5-isoquinolyl


477.
ethyl
2-(trifluoroacetyl)-




1,2,3,4-tetrahydroisoquinolin-7-yl


478.
ethyl
5-chloro-3-methylbenzothiophen-2-yl


479.
ethyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


480.
ethyl
benzothiazol-6-yl


481.
ethyl
benzo[2,1,3]oxadiazol-4-yl


482.
ethyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


483.
ethyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


484.
ethyl
benzo[2,1,3]thiadiazol-4-yl


485.
methyl
4-methylphenyl


486.
methyl
4-ethylphenyl


487.
methyl
4-propylphenyl


488.
methyl
4-isopropylphenyl


489.
methyl
4-sec-butylphenyl


490.
methyl
4-isobutylphenyl


491.
methyl
4-(1,1-dimethylpropyl)-phenyl


492.
methyl
4-vinylphenyl


493.
methyl
4-isopropenylphenyl


494.
methyl
4-fluorophenyl


495.
methyl
4-chlorophenyl


496.
methyl
4-bromophenyl


497.
methyl
4-(fluoromethyl)phenyl


498.
methyl
3-(fluoromethyl)phenyl


499.
methyl
2-(fluoromethyl)phenyl


500.
methyl
4-(difluoromethyl)phenyl


501.
methyl
3-(difluoromethyl)phenyl


502.
methyl
2-(difluoromethyl)phenyl


503.
methyl
4-(trifluoromethyl)phenyl


504.
methyl
3-(trifluoromethyl)phenyl


505.
methyl
2-(trifluoromethyl)phenyl


506.
methyl
4-(1-fluoroethyl)-phenyl


507.
methyl
4-((S)-1-fluoroethyl)-phenyl


508.
methyl
4-((R)-1-fluoroethyl)-phenyl


509.
methyl
4-(2-fluoroethyl)-phenyl


510.
methyl
4-(1,1-difluoroethyl)-phenyl


511.
methyl
4-(2,2-difluoroethyl)-phenyl


512.
methyl
4-(2,2,2-trifluoroethyl)-phenyl


513.
methyl
4-(3-fluoropropyl)-phenyl


514.
methyl
4-(2-fluoropropyl)-phenyl


515.
methyl
4-((S)-2-fluoropropyl)-phenyl


516.
methyl
4-((R)-2-fluoropropyl)-phenyl


517.
methyl
4-(3,3-difluoropropyl)-phenyl


518.
methyl
4-(3,3,3-trifluoropropyl)-phenyl


519.
methyl
4-(1-fluoro-1-methylethyl)-phenyl


520.
methyl
4-(2-fluoro-1-methylethyl)-phenyl


521.
methyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


522.
methyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


523.
methyl
4-(2,2-difluoro-1-methylethyl)-phenyl


524.
methyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


525.
methyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


526.
methyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


527.
methyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


528.
methyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


529.
methyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


530.
methyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


531.
methyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


532.
methyl
4-methoxyphenyl


533.
methyl
4-ethoxyphenyl


534.
methyl
4-propoxyphenyl


535.
methyl
4-isopropoxyphenyl


536.
methyl
4-butoxyphenyl


537.
methyl
4-(fluoromethoxy)-phenyl


538.
methyl
4-(difluoromethoxy)-phenyl


539.
methyl
4-(trifluoromethoxy)-phenyl


540.
methyl
3-(trifluoromethoxy)-phenyl


541.
methyl
4-(2-fluoroethoxy)-phenyl


542.
methyl
4-(2,2-difluoroethoxy)-phenyl


543.
methyl
4-(2,2,2-trifluoroethoxy)-phenyl


544.
methyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


545.
methyl
4-cyclopropylphenyl


546.
methyl
4-cyclobutylphenyl


547.
methyl
4-cyclopentylphenyl


548.
methyl
4-(2,2-difluorocyclopropyl)-phenyl


549.
methyl
3,4-difluorophenyl


550.
methyl
4-bromo-3-fluorophenyl


551.
methyl
4-bromo-2-fluorophenyl


552.
methyl
4-bromo-2,5-difluorophenyl


553.
methyl
2-fluoro-4-isopropylphenyl


554.
methyl
3-fluoro-4-isopropylphenyl


555.
methyl
4-(1-hydroxy-1-methylethyl)-phenyl


556.
methyl
4-(2-hydroxy-2-methylpropyl)-phenyl


557.
methyl
4-acetylphenyl


558.
methyl
4-carboxyphenyl


559.
methyl
4-cyanophenyl


560.
methyl
4-hydroxyphenyl


561.
methyl
4-(O-benzyl)-phenyl


562.
methyl
4-(2-methoxyethoxy)-phenyl


563.
methyl
4-(CH2—N(CH3)2)-phenyl


564.
methyl
4-(NH—CO—NH2)-phenyl


565.
methyl
4-(methylsulfanyl)-phenyl


566.
methyl
4-(fluoromethylsulfanyl)-phenyl


567.
methyl
4-(difluoromethylsulfanyl)-phenyl


568.
methyl
4-(trifluoromethylsulfanyl)-phenyl


569.
methyl
4-(methylsulfonyl)-phenyl


570.
methyl
4-(N-methoxy-N-methyl-amino)-phenyl


571.
methyl
4-(methoxyamino)-phenyl


572.
methyl
4-(ethoxyamino)-phenyl


573.
methyl
4-(N-methylaminooxy)-phenyl


574.
methyl
4-(N,N-dimethylaminooxy)-phenyl


575.
methyl
4-(azetidin-1-yl)-phenyl


576.
methyl
4-(2-methylazetidin-1-yl)-phenyl


577.
methyl
4-((S)-2-methylazetidin-1-yl)-phenyl


578.
methyl
4-((R)-2-methylazetidin-1-yl)-phenyl


579.
methyl
4-(3-fluoroazetidin-1-yl)-phenyl


580.
methyl
4-(3-methoxyazetidin-1-yl)-phenyl


581.
methyl
4-(3-hydroxyazetidin-1-yl)-phenyl


582.
methyl
4-(pyrrolidin-1-yl)-phenyl


583.
methyl
4-(pyrrolidin-2-yl)-phenyl


584.
methyl
4-((S)-pyrrolidin-2-yl)-phenyl


585.
methyl
4-((R)-pyrrolidin-2-yl)-phenyl


586.
methyl
4-(pyrrolidin-3-yl)-phenyl


587.
methyl
4-((S)-pyrrolidin-3-yl)-phenyl


588.
methyl
4-((R)-pyrrolidin-3-yl)-phenyl


589.
methyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


590.
methyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


591.
methyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


592.
methyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


593.
methyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


594.
methyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


595.
methyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


596.
methyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


597.
methyl
4-(2-methylpyrrolidin-1-yl)-phenyl


598.
methyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


599.
methyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


600.
methyl
4-(3-methylpyrrolidin-1-yl)-phenyl


601.
methyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


602.
methyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


603.
methyl
4-(1-methylpyrrolidin-2-yl)-phenyl


604.
methyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


605.
methyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


606.
methyl
4-(1-methylpyrrolidin-3-yl)-phenyl


607.
methyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


608.
methyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


609.
methyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


610.
methyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


611.
methyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


612.
methyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


613.
methyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


614.
methyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


615.
methyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


616.
methyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


617.
methyl
4-(2-oxopyrrolidin-1-yl)-phenyl


618.
methyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


619.
methyl
4-(piperidin-1-yl)-phenyl


620.
methyl
4-(2-methylpiperidin-1-yl)-phenyl


621.
methyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


622.
methyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


623.
methyl
4-(piperazin-1-yl)-phenyl


624.
methyl
4-(4-methylpiperazin-1-yl)-phenyl


625.
methyl
4-(morpholin-4-yl)-phenyl


626.
methyl
4-(thiomorpholin-4-yl)-phenyl


627.
methyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


628.
methyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


629.
methyl
4-(pyrrol-1-yl)-phenyl


630.
methyl
4-(pyrrol-2-yl)-phenyl


631.
methyl
4-(pyrrol-3-yl)-phenyl


632.
methyl
4-(1-methylpyrrol-2-yl)-phenyl


633.
methyl
4-(1-methylpyrrol-3-yl)-phenyl


634.
methyl
4-(furan-2-yl)-phenyl


635.
methyl
4-(furan-3-yl)-phenyl


636.
methyl
4-(thiophen-2-yl)-phenyl


637.
methyl
4-(thiophen-3-yl)-phenyl


638.
methyl
4-(5-propylthien-2-yl)-phenyl


639.
methyl
4-(pyrazol-1-yl)-phenyl


640.
methyl
4-(pyrazol-3-yl)-phenyl


641.
methyl
4-(pyrazol-4-yl)-phenyl


642.
methyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


643.
methyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


644.
methyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


645.
methyl
4-(1H-imidazol-2-yl)-phenyl


646.
methyl
4-(imidazol-1-yl)-phenyl


647.
methyl
4-(1-methylimidazol-2-yl)-phenyl


648.
methyl
4-(oxazol-2-yl)-phenyl


649.
methyl
4-(oxazol-4-yl)-phenyl


650.
methyl
4-(oxazol-5-yl)-phenyl


651.
methyl
4-(isoxazol-3-yl)-phenyl


652.
methyl
4-(isoxazol-4-yl)-phenyl


653.
methyl
4-(isoxazol-5-yl)-phenyl


654.
methyl
4-([1,2,3]-triazol-1-yl)-phenyl


655.
methyl
4-([1,2,4]-triazol-1-yl)-phenyl


656.
methyl
4-([1,2,3]-triazol-2-yl)-phenyl


657.
methyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


658.
methyl
4-([1,2,4]-triazol-4-yl)-phenyl


659.
methyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


660.
methyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


661.
methyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


662.
methyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


663.
methyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


664.
methyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


665.
methyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


666.
methyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


667.
methyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


668.
methyl
4-(1H-tetrazol-5-yl)-phenyl


669.
methyl
4-(tetrazol-1-yl)-phenyl


670.
methyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


671.
methyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


672.
methyl
4-furazan-3-yl-phenyl


673.
methyl
4-(pyrid-2-yl)-phenyl


674.
methyl
4-(pyrid-3-yl)-phenyl


675.
methyl
4-(pyrid-4-yl)-phenyl


676.
methyl
4-(pyrimidin-2-yl)-phenyl


677.
methyl
4-(pyrimidin-4-yl)-phenyl


678.
methyl
4-(pyrimidin-5-yl)-phenyl


679.
methyl
5-isopropylthiophen-2-yl


680.
methyl
2-chlorothiophen-5-yl


681.
methyl
2,5-dichlorothiophen-4-yl


682.
methyl
2,3-dichlorothiophen-5-yl


683.
methyl
2-chloro-3-nitrothiophen-5-yl


684.
methyl
2-(phenylsulfonyl)-thiophen-5-yl


685.
methyl
2-(pyridin-2-yl)thiophen-5-yl


686.
methyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


687.
methyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


688.
methyl
1-methyl-1H-imidazol-4-yl


689.
methyl
1,2-dimethyl-1H-imidazol-4-yl


690.
methyl
3,5-dimethylisoxazol-4-yl


691.
methyl
thiazol-2-yl


692.
methyl
4-methylthiazol-2-yl


693.
methyl
4-isopropylthiazol-2-yl


694.
methyl
4-trifluoromethylthiazol-2-yl


695.
methyl
5-methylthiazol-2-yl


696.
methyl
5-isopropylthiazol-2-yl


697.
methyl
5-trifluoromethylthiazol-2-yl


698.
methyl
2,4-dimethylthiazol-5-yl


699.
methyl
2-acetamido-4-methylthiazol-5-yl


700.
methyl
4H-[1,2,4]triazol-3-yl


701.
methyl
5-methyl-4H-[1,2,4]triazol-3-yl


702.
methyl
4-methyl-4H-[1,2,4]triazol-3-yl


703.
methyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


704.
methyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


705.
methyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


706.
methyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


707.
methyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


708.
methyl
[1,3,4]thiadiazol-2-yl


709.
methyl
5-methyl-[1,3,4]thiadiazol-2-yl


710.
methyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


711.
methyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


712.
methyl
3-bromo-2-chloropyrid-5-yl


713.
methyl
2-(4-morpholino)-pyrid-5-yl


714.
methyl
2-phenoxypyrid-5-yl


715.
methyl
(2-isopropyl)-pyrimidin-5-yl


716.
methyl
(5-isopropyl)-pyrimidin-2-yl


717.
methyl
8-quinolyl


718.
methyl
5-isoquinolyl


719.
methyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


720.
methyl
5-chloro-3-methylbenzothiophen-2-yl


721.
methyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


722.
methyl
benzothiazol-6-yl


723.
methyl
benzo[2,1,3]oxadiazol-4-yl


724.
methyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


725.
methyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


726.
methyl
benzo[2,1,3]thiadiazol-4-yl


727.
H
4-methylphenyl


728.
H
4-ethylphenyl


729.
H
4-propylphenyl


730.
H
4-isopropylphenyl


731.
H
4-sec-butylphenyl


732.
H
4-isobutylphenyl


733.
H
4-(1,1-dimethylpropyl)-phenyl


734.
H
4-vinylphenyl


735.
H
4-isopropenylphenyl


736.
H
4-fluorophenyl


737.
H
4-chlorophenyl


738.
H
4-bromophenyl


739.
H
4-(fluoromethyl)phenyl


740.
H
3-(fluoromethyl)phenyl


741.
H
2-(fluoromethyl)phenyl


742.
H
4-(difluoromethyl)phenyl


743.
H
3-(difluoromethyl)phenyl


744.
H
2-(difluoromethyl)phenyl


745.
H
4-(trifluoromethyl)phenyl


746.
H
3-(trifluoromethyl)phenyl


747.
H
2-(trifluoromethyl)phenyl


748.
H
4-(1-fluoroethyl)-phenyl


749.
H
4-((S)-1-fluoroethyl)-phenyl


750.
H
4-((R)-1-fluoroethyl)-phenyl


751.
H
4-(2-fluoroethyl)-phenyl


752.
H
4-(1,1-difluoroethyl)-phenyl


753.
H
4-(2,2-difluoroethyl)-phenyl


754.
H
4-(2,2,2-trifluoroethyl)-phenyl


755.
H
4-(3-fluoropropyl)-phenyl


756.
H
4-(2-fluoropropyl)-phenyl


757.
H
4-((S)-2-fluoropropyl)-phenyl


758.
H
4-((R)-2-fluoropropyl)-phenyl


759.
H
4-(3,3-difluoropropyl)-phenyl


760.
H
4-(3,3,3-trifluoropropyl)-phenyl


761.
H
4-(1-fluoro-1-methylethyl)-phenyl


762.
H
4-(2-fluoro-1-methylethyl)-phenyl


763.
H
4-((S)-2-fluoro-1-methylethyl)-phenyl


764.
H
4-((R)-2-fluoro-1-methylethyl)-phenyl


765.
H
4-(2,2-difluoro-1-methylethyl)-phenyl


766.
H
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


767.
H
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


768.
H
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


769.
H
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


770.
H
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


771.
H
4-(2-fluoro-1-fluoromethylethyl)-phenyl


772.
H
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


773.
H
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


774.
H
4-methoxyphenyl


775.
H
4-ethoxyphenyl


776.
H
4-propoxyphenyl


777.
H
4-isopropoxyphenyl


778.
H
4-butoxyphenyl


779.
H
4-(fluoromethoxy)-phenyl


780.
H
4-(difluoromethoxy)-phenyl


781.
H
4-(trifluoromethoxy)-phenyl


782.
H
3-(trifluoromethoxy)-phenyl


783.
H
4-(2-fluoroethoxy)-phenyl


784.
H
4-(2,2-difluoroethoxy)-phenyl


785.
H
4-(2,2,2-trifluoroethoxy)-phenyl


786.
H
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


787.
H
4-cyclopropylphenyl


788.
H
4-cyclobutylphenyl


789.
H
4-cyclopentylphenyl


790.
H
4-(2,2-difluorocyclopropyl)-phenyl


791.
H
3,4-difluorophenyl


792.
H
4-bromo-3-fluorophenyl


793.
H
4-bromo-2-fluorophenyl


794.
H
4-bromo-2,5-difluorophenyl


795.
H
2-fluoro-4-isopropylphenyl


796.
H
3-fluoro-4-isopropylphenyl


797.
H
4-(1-hydroxy-1-methylethyl)-phenyl


798.
H
4-(2-hydroxy-2-methylpropyl)-phenyl


799.
H
4-acetylphenyl


800.
H
4-carboxyphenyl


801.
H
4-cyanophenyl


802.
H
4-hydroxyphenyl


803.
H
4-(O-benzyl)-phenyl


804.
H
4-(2-methoxyethoxy)-phenyl


805.
H
4-(CH2—N(CH3)2)-phenyl


806.
H
4-(NH—CO—NH2)-phenyl


807.
H
4-(methylsulfanyl)-phenyl


808.
H
4-(fluoromethylsulfanyl)-phenyl


809.
H
4-(difluoromethylsulfanyl)-phenyl


810.
H
4-(trifluoromethylsulfanyl)-phenyl


811.
H
4-(methylsulfonyl)-phenyl


812.
H
4-(N-methoxy-N-methyl-amino)-phenyl


813.
H
4-(methoxyamino)-phenyl


814.
H
4-(ethoxyamino)-phenyl


815.
H
4-(N-methylaminooxy)-phenyl


816.
H
4-(N,N-dimethylaminooxy)-phenyl


817.
H
4-(azetidin-1-yl)-phenyl


818.
H
4-(2-methylazetidin-1-yl)-phenyl


819.
H
4-((S)-2-methylazetidin-1-yl)-phenyl


820.
H
4-((R)-2-methylazetidin-1-yl)-phenyl


821.
H
4-(3-fluoroazetidin-1-yl)-phenyl


822.
H
4-(3-methoxyazetidin-1-yl)-phenyl


823.
H
4-(3-hydroxyazetidin-1-yl)-phenyl


824.
H
4-(pyrrolidin-1-yl)-phenyl


825.
H
4-(pyrrolidin-2-yl)-phenyl


826.
H
4-((S)-pyrrolidin-2-yl)-phenyl


827.
H
4-((R)-pyrrolidin-2-yl)-phenyl


828.
H
4-(pyrrolidin-3-yl)-phenyl


829.
H
4-((S)-pyrrolidin-3-yl)-phenyl


830.
H
4-((R)-pyrrolidin-3-yl)-phenyl


831.
H
4-(2-fluoropyrrolidin-1-yl)-phenyl


832.
H
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


833.
H
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


834.
H
4-(3-fluoropyrrolidin-1-yl)-phenyl


835.
H
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


836.
H
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


837.
H
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


838.
H
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


839.
H
4-(2-methylpyrrolidin-1-yl)-phenyl


840.
H
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


841.
H
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


842.
H
4-(3-methylpyrrolidin-1-yl)-phenyl


843.
H
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


844.
H
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


845.
H
4-(1-methylpyrrolidin-2-yl)-phenyl


846.
H
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


847.
H
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


848.
H
4-(1-methylpyrrolidin-3-yl)-phenyl


849.
H
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


850.
H
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


851.
H
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


852.
H
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


853.
H
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


854.
H
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


855.
H
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


856.
H
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


857.
H
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


858.
H
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


859.
H
4-(2-oxopyrrolidin-1-yl)-phenyl


860.
H
4-(2-oxo-oxazolidin-3-yl)-phenyl


861.
H
4-(piperidin-1-yl)-phenyl


862.
H
4-(2-methylpiperidin-1-yl)-phenyl


863.
H
4-((S)-2-methylpiperidin-1-yl)-phenyl


864.
H
4-((R)-2-methylpiperidin-1-yl)-phenyl


865.
H
4-(piperazin-1-yl)-phenyl


866.
H
4-(4-methylpiperazin-1-yl)-phenyl


867.
H
4-(morpholin-4-yl)-phenyl


868.
H
4-(thiomorpholin-4-yl)-phenyl


869.
H
4-(1-oxo-thiomorpholin-4-yl)-phenyl


870.
H
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


871.
H
4-(pyrrol-1-yl)-phenyl


872.
H
4-(pyrrol-2-yl)-phenyl


873.
H
4-(pyrrol-3-yl)-phenyl


874.
H
4-(1-methylpyrrol-2-yl)-phenyl


875.
H
4-(1-methylpyrrol-3-yl)-phenyl


876.
H
4-(furan-2-yl)-phenyl


877.
H
4-(furan-3-yl)-phenyl


878.
H
4-(thiophen-2-yl)-phenyl


879.
H
4-(thiophen-3-yl)-phenyl


880.
H
4-(5-propylthien-2-yl)-phenyl


881.
H
4-(pyrazol-1-yl)-phenyl


882.
H
4-(pyrazol-3-yl)-phenyl


883.
H
4-(pyrazol-4-yl)-phenyl


884.
H
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


885.
H
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


886.
H
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


887.
H
4-(1H-imidazol-2-yl)-phenyl


888.
H
4-(imidazol-1-yl)-phenyl


889.
H
4-(1-methylimidazol-2-yl)-phenyl


890.
H
4-(oxazol-2-yl)-phenyl


891.
H
4-(oxazol-4-yl)-phenyl


892.
H
4-(oxazol-5-yl)-phenyl


893.
H
4-(isoxazol-3-yl)-phenyl


894.
H
4-(isoxazol-4-yl)-phenyl


895.
H
4-(isoxazol-5-yl)-phenyl


896.
H
4-([1,2,3]-triazol-1-yl)-phenyl


897.
H
4-([1,2,4]-triazol-1-yl)-phenyl


898.
H
4-([1,2,3]-triazol-2-yl)-phenyl


899.
H
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


900.
H
4-([1,2,4]-triazol-4-yl)-phenyl


901.
H
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


902.
H
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


903.
H
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


904.
H
4-([1,3,4]-oxadiazol-2-yl)-phenyl


905.
H
4-([1,2,4]-oxadiazol-3-yl)-phenyl


906.
H
4-([1,2,4]-oxadiazol-5-yl)-phenyl


907.
H
4-([1,2,3]-oxadiazol-4-yl)-phenyl


908.
H
4-([1,2,3]-oxadiazol-5-yl)-phenyl


909.
H
4-([1,2,3]-thiadiazol-4-yl)-phenyl


910.
H
4-(1H-tetrazol-5-yl)-phenyl


911.
H
4-(tetrazol-1-yl)-phenyl


912.
H
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


913.
H
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


914.
H
4-furazan-3-yl-phenyl


915.
H
4-(pyrid-2-yl)-phenyl


916.
H
4-(pyrid-3-yl)-phenyl


917.
H
4-(pyrid-4-yl)-phenyl


918.
H
4-(pyrimidin-2-yl)-phenyl


919.
H
4-(pyrimidin-4-yl)-phenyl


920.
H
4-(pyrimidin-5-yl)-phenyl


921.
H
5-isopropylthiophen-2-yl


922.
H
2-chlorothiophen-5-yl


923.
H
2,5-dichlorothiophen-4-yl


924.
H
2,3-dichlorothiophen-5-yl


925.
H
2-chloro-3-nitrothiophen-5-yl


926.
H
2-(phenylsulfonyl)-thiophen-5-yl


927.
H
2-(pyridin-2-yl)thiophen-5-yl


928.
H
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


929.
H
2-(2-methylthiazol-4-yl)-thiophen-5-yl


930.
H
1-methyl-1H-imidazol-4-yl


931.
H
1,2-dimethyl-1H-imidazol-4-yl


932.
H
3,5-dimethylisoxazol-4-yl


933.
H
thiazol-2-yl


934.
H
4-methylthiazol-2-yl


935.
H
4-isopropylthiazol-2-yl


936.
H
4-trifluoromethylthiazol-2-yl


937.
H
5-methylthiazol-2-yl


938.
H
5-isopropylthiazol-2-yl


939.
H
5-trifluoromethylthiazol-2-yl


940.
H
2,4-dimethylthiazol-5-yl


941.
H
2-acetamido-4-methylthiazol-5-yl


942.
H
4H-[1,2,4]triazol-3-yl


943.
H
5-methyl-4H-[1,2,4]triazol-3-yl


944.
H
4-methyl-4H-[1,2,4]triazol-3-yl


945.
H
5-isopropyl-4H-[1,2,4]triazol-3-yl


946.
H
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


947.
H
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


948.
H
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


949.
H
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


950.
H
[1,3,4]thiadiazol-2-yl


951.
H
5-methyl-[1,3,4]thiadiazol-2-yl


952.
H
5-isopropyl-[1,3,4]thiadiazol-2-yl


953.
H
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


954.
H
3-bromo-2-chloropyrid-5-yl


955.
H
2-(4-morpholino)-pyrid-5-yl


956.
H
2-phenoxypyrid-5-yl


957.
H
(2-isopropyl)-pyrimidin-5-yl


958.
H
(5-isopropyl)-pyrimidin-2-yl


959.
H
8-quinolyl


960.
H
5-isoquinolyl


961.
H
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


962.
H
5-chloro-3-methylbenzothiophen-2-yl


963.
H
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


964.
H
benzothiazol-6-yl


965.
H
benzo[2,1,3]oxadiazol-4-yl


966.
H
5-chlorobenzo[2,1,3]oxadiazol-4-yl


967.
H
7-chlorobenzo[2,1,3]oxadiazol-4-yl


968.
H
benzo[2,1,3]thiadiazol-4-yl


969.
3-fluoropropyl
4-methylphenyl


970.
3-fluoropropyl
4-ethylphenyl


971.
3-fluoropropyl
4-propylphenyl


972.
3-fluoropropyl
4-isopropylphenyl


973.
3-fluoropropyl
4-sec-butylphenyl


974.
3-fluoropropyl
4-isobutylphenyl


975.
3-fluoropropyl
4-(1,1-dimethylpropyl)-phenyl


976.
3-fluoropropyl
4-vinylphenyl


977.
3-fluoropropyl
4-isopropenylphenyl


978.
3-fluoropropyl
4-fluorophenyl


979.
3-fluoropropyl
4-chlorophenyl


980.
3-fluoropropyl
4-bromophenyl


981.
3-fluoropropyl
4-(fluoromethyl)phenyl


982.
3-fluoropropyl
3-(fluoromethyl)phenyl


983.
3-fluoropropyl
2-(fluoromethyl)phenyl


984.
3-fluoropropyl
4-(difluoromethyl)phenyl


985.
3-fluoropropyl
3-(difluoromethyl)phenyl


986.
3-fluoropropyl
2-(difluoromethyl)phenyl


987.
3-fluoropropyl
4-(trifluoromethyl)phenyl


988.
3-fluoropropyl
3-(trifluoromethyl)phenyl


989.
3-fluoropropyl
2-(trifluoromethyl)phenyl


990.
3-fluoropropyl
4-(1-fluoroethyl)-phenyl


991.
3-fluoropropyl
4-((S)-1-fluoroethyl)-phenyl


992.
3-fluoropropyl
4-((R)-1-fluoroethyl)-phenyl


993.
3-fluoropropyl
4-(2-fluoroethyl)-phenyl


994.
3-fluoropropyl
4-(1,1-difluoroethyl)-phenyl


995.
3-fluoropropyl
4-(2,2-difluoroethyl)-phenyl


996.
3-fluoropropyl
4-(2,2,2-trifluoroethyl)-phenyl


997.
3-fluoropropyl
4-(3-fluoropropyl)-phenyl


998.
3-fluoropropyl
4-(2-fluoropropyl)-phenyl


999.
3-fluoropropyl
4-((S)-2-fluoropropyl)-phenyl


1000.
3-fluoropropyl
4-((R)-2-fluoropropyl)-phenyl


1001.
3-fluoropropyl
4-(3,3-difluoropropyl)-phenyl


1002.
3-fluoropropyl
4-(3,3,3-trifluoropropyl)-phenyl


1003.
3-fluoropropyl
4-(1-fluoro-1-methylethyl)-phenyl


1004.
3-fluoropropyl
4-(2-fluoro-1-methylethyl)-phenyl


1005.
3-fluoropropyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


1006.
3-fluoropropyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


1007.
3-fluoropropyl
4-(2,2-difluoro-1-methylethyl)-phenyl


1008.
3-fluoropropyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


1009.
3-fluoropropyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


1010.
3-fluoropropyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


1011.
3-fluoropropyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


1012.
3-fluoropropyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


1013.
3-fluoropropyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


1014.
3-fluoropropyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


1015.
3-fluoropropyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


1016.
3-fluoropropyl
4-methoxyphenyl


1017.
3-fluoropropyl
4-ethoxyphenyl


1018.
3-fluoropropyl
4-propoxyphenyl


1019.
3-fluoropropyl
4-isopropoxyphenyl


1020.
3-fluoropropyl
4-butoxyphenyl


1021.
3-fluoropropyl
4-(fluoromethoxy)-phenyl


1022.
3-fluoropropyl
4-(difluoromethoxy)-phenyl


1023.
3-fluoropropyl
4-(trifluoromethoxy)-phenyl


1024.
3-fluoropropyl
3-(trifluoromethoxy)-phenyl


1025.
3-fluoropropyl
4-(2-fluoroethoxy)-phenyl


1026.
3-fluoropropyl
4-(2,2-difluoroethoxy)-phenyl


1027.
3-fluoropropyl
4-(2,2,2-trifluoroethoxy)-phenyl


1028.
3-fluoropropyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


1029.
3-fluoropropyl
4-cyclopropylphenyl


1030.
3-fluoropropyl
4-cyclobutylphenyl


1031.
3-fluoropropyl
4-cyclopentylphenyl


1032.
3-fluoropropyl
4-(2,2-difluorocyclopropyl)-phenyl


1033.
3-fluoropropyl
3,4-difluorophenyl


1034.
3-fluoropropyl
4-bromo-3-fluorophenyl


1035.
3-fluoropropyl
4-bromo-2-fluorophenyl


1036.
3-fluoropropyl
4-bromo-2,5-difluorophenyl


1037.
3-fluoropropyl
2-fluoro-4-isopropylphenyl


1038.
3-fluoropropyl
3-fluoro-4-isopropylphenyl


1039.
3-fluoropropyl
4-(1-hydroxy-1-methylethyl)-phenyl


1040.
3-fluoropropyl
4-(2-hydroxy-2-methylpropyl)-phenyl


1041.
3-fluoropropyl
4-acetylphenyl


1042.
3-fluoropropyl
4-carboxyphenyl


1043.
3-fluoropropyl
4-cyanophenyl


1044.
3-fluoropropyl
4-hydroxyphenyl


1045.
3-fluoropropyl
4-(O-benzyl)-phenyl


1046.
3-fluoropropyl
4-(2-methoxyethoxy)-phenyl


1047.
3-fluoropropyl
4-(CH2—N(CH3)2)-phenyl


1048.
3-fluoropropyl
4-(NH—CO—NH2)-phenyl


1049.
3-fluoropropyl
4-(methylsulfanyl)-phenyl


1050.
3-fluoropropyl
4-(fluoromethylsulfanyl)-phenyl


1051.
3-fluoropropyl
4-(difluoromethylsulfanyl)-phenyl


1052.
3-fluoropropyl
4-(trifluoromethylsulfanyl)-phenyl


1053.
3-fluoropropyl
4-(methylsulfonyl)-phenyl


1054.
3-fluoropropyl
4-(N-methoxy-N-methyl-amino)-phenyl


1055.
3-fluoropropyl
4-(methoxyamino)-phenyl


1056.
3-fluoropropyl
4-(ethoxyamino)-phenyl


1057.
3-fluoropropyl
4-(N-methylaminooxy)-phenyl


1058.
3-fluoropropyl
4-(N,N-dimethylaminooxy)-phenyl


1059.
3-fluoropropyl
4-(azetidin-1-yl)-phenyl


1060.
3-fluoropropyl
4-(2-methylazetidin-1-yl)-phenyl


1061.
3-fluoropropyl
4-((S)-2-methylazetidin-1-yl)-phenyl


1062.
3-fluoropropyl
4-((R)-2-methylazetidin-1-yl)-phenyl


1063.
3-fluoropropyl
4-(3-fluoroazetidin-1-yl)-phenyl


1064.
3-fluoropropyl
4-(3-methoxyazetidin-1-yl)-phenyl


1065.
3-fluoropropyl
4-(3-hydroxyazetidin-1-yl)-phenyl


1066.
3-fluoropropyl
4-(pyrrolidin-1-yl)-phenyl


1067.
3-fluoropropyl
4-(pyrrolidin-2-yl)-phenyl


1068.
3-fluoropropyl
4-((S)-pyrrolidin-2-yl)-phenyl


1069.
3-fluoropropyl
4-((R)-pyrrolidin-2-yl)-phenyl


1070.
3-fluoropropyl
4-(pyrrolidin-3-yl)-phenyl


1071.
3-fluoropropyl
4-((S)-pyrrolidin-3-yl)-phenyl


1072.
3-fluoropropyl
4-((R)-pyrrolidin-3-yl)-phenyl


1073.
3-fluoropropyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


1074.
3-fluoropropyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


1075.
3-fluoropropyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


1076.
3-fluoropropyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


1077.
3-fluoropropyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


1078.
3-fluoropropyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


1079.
3-fluoropropyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


1080.
3-fluoropropyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


1081.
3-fluoropropyl
4-(2-methylpyrrolidin-1-yl)-phenyl


1082.
3-fluoropropyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


1083.
3-fluoropropyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


1084.
3-fluoropropyl
4-(3-methylpyrrolidin-1-yl)-phenyl


1085.
3-fluoropropyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


1086.
3-fluoropropyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


1087.
3-fluoropropyl
4-(1-methylpyrrolidin-2-yl)-phenyl


1088.
3-fluoropropyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


1089.
3-fluoropropyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


1090.
3-fluoropropyl
4-(1-methylpyrrolidin-3-yl)-phenyl


1091.
3-fluoropropyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


1092.
3-fluoropropyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


1093.
3-fluoropropyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


1094.
3-fluoropropyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


1095.
3-fluoropropyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


1096.
3-fluoropropyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1097.
3-fluoropropyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1098.
3-fluoropropyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


1099.
3-fluoropropyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1100.
3-fluoropropyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1101.
3-fluoropropyl
4-(2-oxopyrrolidin-1-yl)-phenyl


1102.
3-fluoropropyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


1103.
3-fluoropropyl
4-(piperidin-1-yl)-phenyl


1104.
3-fluoropropyl
4-(2-methylpiperidin-1-yl)-phenyl


1105.
3-fluoropropyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


1106.
3-fluoropropyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


1107.
3-fluoropropyl
4-(piperazin-1-yl)-phenyl


1108.
3-fluoropropyl
4-(4-methylpiperazin-1-yl)-phenyl


1109.
3-fluoropropyl
4-(morpholin-4-yl)-phenyl


1110.
3-fluoropropyl
4-(thiomorpholin-4-yl)-phenyl


1111.
3-fluoropropyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


1112.
3-fluoropropyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


1113.
3-fluoropropyl
4-(pyrrol-1-yl)-phenyl


1114.
3-fluoropropyl
4-(pyrrol-2-yl)-phenyl


1115.
3-fluoropropyl
4-(pyrrol-3-yl)-phenyl


1116.
3-fluoropropyl
4-(1-methylpyrrol-2-yl)-phenyl


1117.
3-fluoropropyl
4-(1-methylpyrrol-3-yl)-phenyl


1118.
3-fluoropropyl
4-(furan-2-yl)-phenyl


1119.
3-fluoropropyl
4-(furan-3-yl)-phenyl


1120.
3-fluoropropyl
4-(thiophen-2-yl)-phenyl


1121.
3-fluoropropyl
4-(thiophen-3-yl)-phenyl


1122.
3-fluoropropyl
4-(5-propylthien-2-yl)-phenyl


1123.
3-fluoropropyl
4-(pyrazol-1-yl)-phenyl


1124.
3-fluoropropyl
4-(pyrazol-3-yl)-phenyl


1125.
3-fluoropropyl
4-(pyrazol-4-yl)-phenyl


1126.
3-fluoropropyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


1127.
3-fluoropropyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


1128.
3-fluoropropyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


1129.
3-fluoropropyl
4-(1H-imidazol-2-yl)-phenyl


1130.
3-fluoropropyl
4-(imidazol-1-yl)-phenyl


1131.
3-fluoropropyl
4-(1-methylimidazol-2-yl)-phenyl


1132.
3-fluoropropyl
4-(oxazol-2-yl)-phenyl


1133.
3-fluoropropyl
4-(oxazol-4-yl)-phenyl


1134.
3-fluoropropyl
4-(oxazol-5-yl)-phenyl


1135.
3-fluoropropyl
4-(isoxazol-3-yl)-phenyl


1136.
3-fluoropropyl
4-(isoxazol-4-yl)-phenyl


1137.
3-fluoropropyl
4-(isoxazol-5-yl)-phenyl


1138.
3-fluoropropyl
4-([1,2,3]-triazol-1-yl)-phenyl


1139.
3-fluoropropyl
4-([1,2,4]-triazol-1-yl)-phenyl


1140.
3-fluoropropyl
4-([1,2,3]-triazol-2-yl)-phenyl


1141.
3-fluoropropyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


1142.
3-fluoropropyl
4-([1,2,4]-triazol-4-yl)-phenyl


1143.
3-fluoropropyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


1144.
3-fluoropropyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


1145.
3-fluoropropyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


1146.
3-fluoropropyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


1147.
3-fluoropropyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


1148.
3-fluoropropyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


1149.
3-fluoropropyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


1150.
3-fluoropropyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


1151.
3-fluoropropyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


1152.
3-fluoropropyl
4-(1H-tetrazol-5-yl)-phenyl


1153.
3-fluoropropyl
4-(tetrazol-1-yl)-phenyl


1154.
3-fluoropropyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


1155.
3-fluoropropyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


1156.
3-fluoropropyl
4-furazan-3-yl-phenyl


1157.
3-fluoropropyl
4-(pyrid-2-yl)-phenyl


1158.
3-fluoropropyl
4-(pyrid-3-yl)-phenyl


1159.
3-fluoropropyl
4-(pyrid-4-yl)-phenyl


1160.
3-fluoropropyl
4-(pyrimidin-2-yl)-phenyl


1161.
3-fluoropropyl
4-(pyrimidin-4-yl)-phenyl


1162.
3-fluoropropyl
4-(pyrimidin-5-yl)-phenyl


1163.
3-fluoropropyl
5-isopropylthiophen-2-yl


1164.
3-fluoropropyl
2-chlorothiophen-5-yl


1165.
3-fluoropropyl
2,5-dichlorothiophen-4-yl


1166.
3-fluoropropyl
2,3-dichlorothiophen-5-yl


1167.
3-fluoropropyl
2-chloro-3-nitrothiophen-5-yl


1168.
3-fluoropropyl
2-(phenylsulfonyl)-thiophen-5-yl


1169.
3-fluoropropyl
2-(pyridin-2-yl)thiophen-5-yl


1170.
3-fluoropropyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


1171.
3-fluoropropyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


1172.
3-fluoropropyl
1-methyl-1H-imidazol-4-yl


1173.
3-fluoropropyl
1,2-dimethyl-1H-imidazol-4-yl


1174.
3-fluoropropyl
3,5-dimethylisoxazol-4-yl


1175.
3-fluoropropyl
thiazol-2-yl


1176.
3-fluoropropyl
4-methylthiazol-2-yl


1177.
3-fluoropropyl
4-isopropylthiazol-2-yl


1178.
3-fluoropropyl
4-trifluoromethylthiazol-2-yl


1179.
3-fluoropropyl
5-methylthiazol-2-yl


1180.
3-fluoropropyl
5-isopropylthiazol-2-yl


1181.
3-fluoropropyl
5-trifluoromethylthiazol-2-yl


1182.
3-fluoropropyl
2,4-dimethylthiazol-5-yl


1183.
3-fluoropropyl
2-acetamido-4-methylthiazol-5-yl


1184.
3-fluoropropyl
4H-[1,2,4]triazol-3-yl


1185.
3-fluoropropyl
5-methyl-4H-[1,2,4]triazol-3-yl


1186.
3-fluoropropyl
4-methyl-4H-[1,2,4]triazol-3-yl


1187.
3-fluoropropyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


1188.
3-fluoropropyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


1189.
3-fluoropropyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


1190.
3-fluoropropyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


1191.
3-fluoropropyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


1192.
3-fluoropropyl
[1,3,4]thiadiazol-2-yl


1193.
3-fluoropropyl
5-methyl-[1,3,4]thiadiazol-2-yl


1194.
3-fluoropropyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


1195.
3-fluoropropyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


1196.
3-fluoropropyl
3-bromo-2-chloropyrid-5-yl


1197.
3-fluoropropyl
2-(4-morpholino)-pyrid-5-yl


1198.
3-fluoropropyl
2-phenoxypyrid-5-yl


1199.
3-fluoropropyl
(2-isopropyl)-pyrimidin-5-yl


1200.
3-fluoropropyl
(5-isopropyl)-pyrimidin-2-yl


1201.
3-fluoropropyl
8-quinolyl


1202.
3-fluoropropyl
5-isoquinolyl


1203.
3-fluoropropyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


1204.
3-fluoropropyl
5-chloro-3-methylbenzothiophen-2-yl


1205.
3-fluoropropyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


1206.
3-fluoropropyl
benzothiazol-6-yl


1207.
3-fluoropropyl
benzo[2,1,3]oxadiazol-4-yl


1208.
3-fluoropropyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


1209.
3-fluoropropyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


1210.
3-fluoropropyl
benzo[2,1,3]thiadiazol-4-yl


1211.
2-fluoroethyl
4-methylphenyl


1212.
2-fluoroethyl
4-ethylphenyl


1213.
2-fluoroethyl
4-propylphenyl


1214.
2-fluoroethyl
4-isopropylphenyl


1215.
2-fluoroethyl
4-sec-butylphenyl


1216.
2-fluoroethyl
4-isobutylphenyl


1217.
2-fluoroethyl
4-(1,1-dimethylpropyl)-phenyl


1218.
2-fluoroethyl
4-vinylphenyl


1219.
2-fluoroethyl
4-isopropenylphenyl


1220.
2-fluoroethyl
4-fluorophenyl


1221.
2-fluoroethyl
4-chlorophenyl


1222.
2-fluoroethyl
4-bromophenyl


1223.
2-fluoroethyl
4-(fluoromethyl)phenyl


1224.
2-fluoroethyl
3-(fluoromethyl)phenyl


1225.
2-fluoroethyl
2-(fluoromethyl)phenyl


1226.
2-fluoroethyl
4-(difluoromethyl)phenyl


1227.
2-fluoroethyl
3-(difluoromethyl)phenyl


1228.
2-fluoroethyl
2-(difluoromethyl)phenyl


1229.
2-fluoroethyl
4-(trifluoromethyl)phenyl


1230.
2-fluoroethyl
3-(trifluoromethyl)phenyl


1231.
2-fluoroethyl
2-(trifluoromethyl)phenyl


1232.
2-fluoroethyl
4-(1-fluoroethyl)-phenyl


1233.
2-fluoroethyl
4-((S)-1-fluoroethyl)-phenyl


1234.
2-fluoroethyl
4-((R)-1-fluoroethyl)-phenyl


1235.
2-fluoroethyl
4-(2-fluoroethyl)-phenyl


1236.
2-fluoroethyl
4-(1,1-difluoroethyl)-phenyl


1237.
2-fluoroethyl
4-(2,2-difluoroethyl)-phenyl


1238.
2-fluoroethyl
4-(2,2,2-trifluoroethyl)-phenyl


1239.
2-fluoroethyl
4-(3-fluoropropyl)-phenyl


1240.
2-fluoroethyl
4-(2-fluoropropyl)-phenyl


1241.
2-fluoroethyl
4-((S)-2-fluoropropyl)-phenyl


1242.
2-fluoroethyl
4-((R)-2-fluoropropyl)-phenyl


1243.
2-fluoroethyl
4-(3,3-difluoropropyl)-phenyl


1244.
2-fluoroethyl
4-(3,3,3-trifluoropropyl)-phenyl


1245.
2-fluoroethyl
4-(1-fluoro-1-methylethyl)-phenyl


1246.
2-fluoroethyl
4-(2-fluoro-1-methylethyl)-phenyl


1247.
2-fluoroethyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


1248.
2-fluoroethyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


1249.
2-fluoroethyl
4-(2,2-difluoro-1-methylethyl)-phenyl


1250.
2-fluoroethyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


1251.
2-fluoroethyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


1252.
2-fluoroethyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


1253.
2-fluoroethyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


1254.
2-fluoroethyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


1255.
2-fluoroethyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


1256.
2-fluoroethyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


1257.
2-fluoroethyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


1258.
2-fluoroethyl
4-methoxyphenyl


1259.
2-fluoroethyl
4-ethoxyphenyl


1260.
2-fluoroethyl
4-propoxyphenyl


1261.
2-fluoroethyl
4-isopropoxyphenyl


1262.
2-fluoroethyl
4-butoxyphenyl


1263.
2-fluoroethyl
4-(fluoromethoxy)-phenyl


1264.
2-fluoroethyl
4-(difluoromethoxy)-phenyl


1265.
2-fluoroethyl
4-(trifluoromethoxy)-phenyl


1266.
2-fluoroethyl
3-(trifluoromethoxy)-phenyl


1267.
2-fluoroethyl
4-(2-fluoroethoxy)-phenyl


1268.
2-fluoroethyl
4-(2,2-difluoroethoxy)-phenyl


1269.
2-fluoroethyl
4-(2,2,2-trifluoroethoxy)-phenyl


1270.
2-fluoroethyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


1271.
2-fluoroethyl
4-cyclopropylphenyl


1272.
2-fluoroethyl
4-cyclobutylphenyl


1273.
2-fluoroethyl
4-cyclopentylphenyl


1274.
2-fluoroethyl
4-(2,2-difluorocyclopropyl)-phenyl


1275.
2-fluoroethyl
3,4-difluorophenyl


1276.
2-fluoroethyl
4-bromo-3-fluorophenyl


1277.
2-fluoroethyl
4-bromo-2-fluorophenyl


1278.
2-fluoroethyl
4-bromo-2,5-difluorophenyl


1279.
2-fluoroethyl
2-fluoro-4-isopropylphenyl


1280.
2-fluoroethyl
3-fluoro-4-isopropylphenyl


1281.
2-fluoroethyl
4-(1-hydroxy-1-methylethyl)-phenyl


1282.
2-fluoroethyl
4-(2-hydroxy-2-methylpropyl)-phenyl


1283.
2-fluoroethyl
4-acetylphenyl


1284.
2-fluoroethyl
4-carboxyphenyl


1285.
2-fluoroethyl
4-cyanophenyl


1286.
2-fluoroethyl
4-hydroxyphenyl


1287.
2-fluoroethyl
4-(O-benzyl)-phenyl


1288.
2-fluoroethyl
4-(2-methoxyethoxy)-phenyl


1289.
2-fluoroethyl
4-(CH2—N(CH3)2)-phenyl


1290.
2-fluoroethyl
4-(NH—CO—NH2)-phenyl


1291.
2-fluoroethyl
4-(methylsulfanyl)-phenyl


1292.
2-fluoroethyl
4-(fluoromethylsulfanyl)-phenyl


1293.
2-fluoroethyl
4-(difluoromethylsulfanyl)-phenyl


1294.
2-fluoroethyl
4-(trifluoromethylsulfanyl)-phenyl


1295.
2-fluoroethyl
4-(methylsulfonyl)-phenyl


1296.
2-fluoroethyl
4-(N-methoxy-N-methyl-amino)-phenyl


1297.
2-fluoroethyl
4-(methoxyamino)-phenyl


1298.
2-fluoroethyl
4-(ethoxyamino)-phenyl


1299.
2-fluoroethyl
4-(N-methylaminooxy)-phenyl


1300.
2-fluoroethyl
4-(N,N-dimethylaminooxy)-phenyl


1301.
2-fluoroethyl
4-(azetidin-1-yl)-phenyl


1302.
2-fluoroethyl
4-(2-methylazetidin-1-yl)-phenyl


1303.
2-fluoroethyl
4-((S)-2-methylazetidin-1-yl)-phenyl


1304.
2-fluoroethyl
4-((R)-2-methylazetidin-1-yl)-phenyl


1305.
2-fluoroethyl
4-(3-fluoroazetidin-1-yl)-phenyl


1306.
2-fluoroethyl
4-(3-methoxyazetidin-1-yl)-phenyl


1307.
2-fluoroethyl
4-(3-hydroxyazetidin-1-yl)-phenyl


1308.
2-fluoroethyl
4-(pyrrolidin-1-yl)-phenyl


1309.
2-fluoroethyl
4-(pyrrolidin-2-yl)-phenyl


1310.
2-fluoroethyl
4-((S)-pyrrolidin-2-yl)-phenyl


1311.
2-fluoroethyl
4-((R)-pyrrolidin-2-yl)-phenyl


1312.
2-fluoroethyl
4-(pyrrolidin-3-yl)-phenyl


1313.
2-fluoroethyl
4-((S)-pyrrolidin-3-yl)-phenyl


1314.
2-fluoroethyl
4-((R)-pyrrolidin-3-yl)-phenyl


1315.
2-fluoroethyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


1316.
2-fluoroethyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


1317.
2-fluoroethyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


1318.
2-fluoroethyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


1319.
2-fluoroethyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


1320.
2-fluoroethyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


1321.
2-fluoroethyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


1322.
2-fluoroethyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


1323.
2-fluoroethyl
4-(2-methylpyrrolidin-1-yl)-phenyl


1324.
2-fluoroethyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


1325.
2-fluoroethyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


1326.
2-fluoroethyl
4-(3-methylpyrrolidin-1-yl)-phenyl


1327.
2-fluoroethyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


1328.
2-fluoroethyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


1329.
2-fluoroethyl
4-(1-methylpyrrolidin-2-yl)-phenyl


1330.
2-fluoroethyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


1331.
2-fluoroethyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


1332.
2-fluoroethyl
4-(1-methylpyrrolidin-3-yl)-phenyl


1333.
2-fluoroethyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


1334.
2-fluoroethyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


1335.
2-fluoroethyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


1336.
2-fluoroethyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


1337.
2-fluoroethyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


1338.
2-fluoroethyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1339.
2-fluoroethyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1340.
2-fluoroethyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


1341.
2-fluoroethyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1342.
2-fluoroethyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1343.
2-fluoroethyl
4-(2-oxopyrrolidin-1-yl)-phenyl


1344.
2-fluoroethyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


1345.
2-fluoroethyl
4-(piperidin-1-yl)-phenyl


1346.
2-fluoroethyl
4-(2-methylpiperidin-1-yl)-phenyl


1347.
2-fluoroethyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


1348.
2-fluoroethyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


1349.
2-fluoroethyl
4-(piperazin-1-yl)-phenyl


1350.
2-fluoroethyl
4-(4-methylpiperazin-1-yl)-phenyl


1351.
2-fluoroethyl
4-(morpholin-4-yl)-phenyl


1352.
2-fluoroethyl
4-(thiomorpholin-4-yl)-phenyl


1353.
2-fluoroethyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


1354.
2-fluoroethyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


1355.
2-fluoroethyl
4-(pyrrol-1-yl)-phenyl


1356.
2-fluoroethyl
4-(pyrrol-2-yl)-phenyl


1357.
2-fluoroethyl
4-(pyrrol-3-yl)-phenyl


1358.
2-fluoroethyl
4-(1-methylpyrrol-2-yl)-phenyl


1359.
2-fluoroethyl
4-(1-methylpyrrol-3-yl)-phenyl


1360.
2-fluoroethyl
4-(furan-2-yl)-phenyl


1361.
2-fluoroethyl
4-(furan-3-yl)-phenyl


1362.
2-fluoroethyl
4-(thiophen-2-yl)-phenyl


1363.
2-fluoroethyl
4-(thiophen-3-yl)-phenyl


1364.
2-fluoroethyl
4-(5-propylthien-2-yl)-phenyl


1365.
2-fluoroethyl
4-(pyrazol-1-yl)-phenyl


1366.
2-fluoroethyl
4-(pyrazol-3-yl)-phenyl


1367.
2-fluoroethyl
4-(pyrazol-4-yl)-phenyl


1368.
2-fluoroethyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


1369.
2-fluoroethyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


1370.
2-fluoroethyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


1371.
2-fluoroethyl
4-(1H-imidazol-2-yl)-phenyl


1372.
2-fluoroethyl
4-(imidazol-1-yl)-phenyl


1373.
2-fluoroethyl
4-(1-methylimidazol-2-yl)-phenyl


1374.
2-fluoroethyl
4-(oxazol-2-yl)-phenyl


1375.
2-fluoroethyl
4-(oxazol-4-yl)-phenyl


1376.
2-fluoroethyl
4-(oxazol-5-yl)-phenyl


1377.
2-fluoroethyl
4-(isoxazol-3-yl)-phenyl


1378.
2-fluoroethyl
4-(isoxazol-4-yl)-phenyl


1379.
2-fluoroethyl
4-(isoxazol-5-yl)-phenyl


1380.
2-fluoroethyl
4-([1,2,3]-triazol-1-yl)-phenyl


1381.
2-fluoroethyl
4-([1,2,4]-triazol-1-yl)-phenyl


1382.
2-fluoroethyl
4-([1,2,3]-triazol-2-yl)-phenyl


1383.
2-fluoroethyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


1384.
2-fluoroethyl
4-([1,2,4]-triazol-4-yl)-phenyl


1385.
2-fluoroethyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


1386.
2-fluoroethyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


1387.
2-fluoroethyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


1388.
2-fluoroethyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


1389.
2-fluoroethyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


1390.
2-fluoroethyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


1391.
2-fluoroethyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


1392.
2-fluoroethyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


1393.
2-fluoroethyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


1394.
2-fluoroethyl
4-(1H-tetrazol-5-yl)-phenyl


1395.
2-fluoroethyl
4-(tetrazol-1-yl)-phenyl


1396.
2-fluoroethyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


1397.
2-fluoroethyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


1398.
2-fluoroethyl
4-furazan-3-yl-phenyl


1399.
2-fluoroethyl
4-(pyrid-2-yl)-phenyl


1400.
2-fluoroethyl
4-(pyrid-3-yl)-phenyl


1401.
2-fluoroethyl
4-(pyrid-4-yl)-phenyl


1402.
2-fluoroethyl
4-(pyrimidin-2-yl)-phenyl


1403.
2-fluoroethyl
4-(pyrimidin-4-yl)-phenyl


1404.
2-fluoroethyl
4-(pyrimidin-5-yl)-phenyl


1405.
2-fluoroethyl
5-isopropylthiophen-2-yl


1406.
2-fluoroethyl
2-chlorothiophen-5-yl


1407.
2-fluoroethyl
2,5-dichlorothiophen-4-yl


1408.
2-fluoroethyl
2,3-dichlorothiophen-5-yl


1409.
2-fluoroethyl
2-chloro-3-nitrothiophen-5-yl


1410.
2-fluoroethyl
2-(phenylsulfonyl)-thiophen-5-yl


1411.
2-fluoroethyl
2-(pyridin-2-yl)thiophen-5-yl


1412.
2-fluoroethyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


1413.
2-fluoroethyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


1414.
2-fluoroethyl
1-methyl-1H-imidazol-4-yl


1415.
2-fluoroethyl
1,2-dimethyl-1H-imidazol-4-yl


1416.
2-fluoroethyl
3,5-dimethylisoxazol-4-yl


1417.
2-fluoroethyl
thiazol-2-yl


1418.
2-fluoroethyl
4-methylthiazol-2-yl


1419.
2-fluoroethyl
4-isopropylthiazol-2-yl


1420.
2-fluoroethyl
4-trifluoromethylthiazol-2-yl


1421.
2-fluoroethyl
5-methylthiazol-2-yl


1422.
2-fluoroethyl
5-isopropylthiazol-2-yl


1423.
2-fluoroethyl
5-trifluoromethylthiazol-2-yl


1424.
2-fluoroethyl
2,4-dimethylthiazol-5-yl


1425.
2-fluoroethyl
2-acetamido-4-methylthiazol-5-yl


1426.
2-fluoroethyl
4H-[1,2,4]triazol-3-yl


1427.
2-fluoroethyl
5-methyl-4H-[1,2,4]triazol-3-yl


1428.
2-fluoroethyl
4-methyl-4H-[1,2,4]triazol-3-yl


1429.
2-fluoroethyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


1430.
2-fluoroethyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


1431.
2-fluoroethyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


1432.
2-fluoroethyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


1433.
2-fluoroethyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


1434.
2-fluoroethyl
[1,3,4]thiadiazol-2-yl


1435.
2-fluoroethyl
5-methyl-[1,3,4]thiadiazol-2-yl


1436.
2-fluoroethyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


1437.
2-fluoroethyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


1438.
2-fluoroethyl
3-bromo-2-chloropyrid-5-yl


1439.
2-fluoroethyl
2-(4-morpholino)-pyrid-5-yl


1440.
2-fluoroethyl
2-phenoxypyrid-5-yl


1441.
2-fluoroethyl
(2-isopropyl)-pyrimidin-5-yl


1442.
2-fluoroethyl
(5-isopropyl)-pyrimidin-2-yl


1443.
2-fluoroethyl
8-quinolyl


1444.
2-fluoroethyl
5-isoquinolyl


1445.
2-fluoroethyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


1446.
2-fluoroethyl
5-chloro-3-methylbenzothiophen-2-yl


1447.
2-fluoroethyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


1448.
2-fluoroethyl
benzothiazol-6-yl


1449.
2-fluoroethyl
benzo[2,1,3]oxadiazol-4-yl


1450.
2-fluoroethyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


1451.
2-fluoroethyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


1452.
2-fluoroethyl
benzo[2,1,3]thiadiazol-4-yl


1453.
cyclopropylmethyl
4-methylphenyl


1454.
cyclopropylmethyl
4-ethylphenyl


1455.
cyclopropylmethyl
4-propylphenyl


1456.
cyclopropylmethyl
4-isopropylphenyl


1457.
cyclopropylmethyl
4-sec-butylphenyl


1458.
cyclopropylmethyl
4-isobutylphenyl


1459.
cyclopropylmethyl
4-(1,1-dimethylpropyl)-phenyl


1460.
cyclopropylmethyl
4-vinylphenyl


1461.
cyclopropylmethyl
4-isopropenylphenyl


1462.
cyclopropylmethyl
4-fluorophenyl


1463.
cyclopropylmethyl
4-chlorophenyl


1464.
cyclopropylmethyl
4-bromophenyl


1465.
cyclopropylmethyl
4-(fluoromethyl)phenyl


1466.
cyclopropylmethyl
3-(fluoromethyl)phenyl


1467.
cyclopropylmethyl
2-(fluoromethyl)phenyl


1468.
cyclopropylmethyl
4-(difluoromethyl)phenyl


1469.
cyclopropylmethyl
3-(difluoromethyl)phenyl


1470.
cyclopropylmethyl
2-(difluoromethyl)phenyl


1471.
cyclopropylmethyl
4-(trifluoromethyl)phenyl


1472.
cyclopropylmethyl
3-(trifluoromethyl)phenyl


1473.
cyclopropylmethyl
2-(trifluoromethyl)phenyl


1474.
cyclopropylmethyl
4-(1-fluoroethyl)-phenyl


1475.
cyclopropylmethyl
4-((S)-1-fluoroethyl)-phenyl


1476.
cyclopropylmethyl
4-((R)-1-fluoroethyl)-phenyl


1477.
cyclopropylmethyl
4-(2-fluoroethyl)-phenyl


1478.
cyclopropylmethyl
4-(1,1-difluoroethyl)-phenyl


1479.
cyclopropylmethyl
4-(2,2-difluoroethyl)-phenyl


1480.
cyclopropylmethyl
4-(2,2,2-trifluoroethyl)-phenyl


1481.
cyclopropylmethyl
4-(3-fluoropropyl)-phenyl


1482.
cyclopropylmethyl
4-(2-fluoropropyl)-phenyl


1483.
cyclopropylmethyl
4-((S)-2-fluoropropyl)-phenyl


1484.
cyclopropylmethyl
4-((R)-2-fluoropropyl)-phenyl


1485.
cyclopropylmethyl
4-(3,3-difluoropropyl)-phenyl


1486.
cyclopropylmethyl
4-(3,3,3-trifluoropropyl)-phenyl


1487.
cyclopropylmethyl
4-(1-fluoro-1-methylethyl)-phenyl


1488.
cyclopropylmethyl
4-(2-fluoro-1-methylethyl)-phenyl


1489.
cyclopropylmethyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


1490.
cyclopropylmethyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


1491.
cyclopropylmethyl
4-(2,2-difluoro-1-methylethyl)-phenyl


1492.
cyclopropylmethyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


1493.
cyclopropylmethyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


1494.
cyclopropylmethyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


1495.
cyclopropylmethyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


1496.
cyclopropylmethyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


1497.
cyclopropylmethyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


1498.
cyclopropylmethyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


1499.
cyclopropylmethyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


1500.
cyclopropylmethyl
4-methoxyphenyl


1501.
cyclopropylmethyl
4-ethoxyphenyl


1502.
cyclopropylmethyl
4-propoxyphenyl


1503.
cyclopropylmethyl
4-isopropoxyphenyl


1504.
cyclopropylmethyl
4-butoxyphenyl


1505.
cyclopropylmethyl
4-(fluoromethoxy)-phenyl


1506.
cyclopropylmethyl
4-(difluoromethoxy)-phenyl


1507.
cyclopropylmethyl
4-(trifluoromethoxy)-phenyl


1508.
cyclopropylmethyl
3-(trifluoromethoxy)-phenyl


1509.
cyclopropylmethyl
4-(2-fluoroethoxy)-phenyl


1510.
cyclopropylmethyl
4-(2,2-difluoroethoxy)-phenyl


1511.
cyclopropylmethyl
4-(2,2,2-trifluoroethoxy)-phenyl


1512.
cyclopropylmethyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


1513.
cyclopropylmethyl
4-cyclopropylphenyl


1514.
cyclopropylmethyl
4-cyclobutylphenyl


1515.
cyclopropylmethyl
4-cyclopentylphenyl


1516.
cyclopropylmethyl
4-(2,2-difluorocyclopropyl)-phenyl


1517.
cyclopropylmethyl
3,4-difluorophenyl


1518.
cyclopropylmethyl
4-bromo-3-fluorophenyl


1519.
cyclopropylmethyl
4-bromo-2-fluorophenyl


1520.
cyclopropylmethyl
4-bromo-2,5-difluorophenyl


1521.
cyclopropylmethyl
2-fluoro-4-isopropylphenyl


1522.
cyclopropylmethyl
3-fluoro-4-isopropylphenyl


1523.
cyclopropylmethyl
4-(1-hydroxy-1-methylethyl)-phenyl


1524.
cyclopropylmethyl
4-(2-hydroxy-2-methylpropyl)-phenyl


1525.
cyclopropylmethyl
4-acetylphenyl


1526.
cyclopropylmethyl
4-carboxyphenyl


1527.
cyclopropylmethyl
4-cyanophenyl


1528.
cyclopropylmethyl
4-hydroxyphenyl


1529.
cyclopropylmethyl
4-(O-benzyl)-phenyl


1530.
cyclopropylmethyl
4-(2-methoxyethoxy)-phenyl


1531.
cyclopropylmethyl
4-(CH2—N(CH3)2)-phenyl


1532.
cyclopropylmethyl
4-(NH—CO—NH2)-phenyl


1533.
cyclopropylmethyl
4-(methylsulfanyl)-phenyl


1534.
cyclopropylmethyl
4-(fluoromethylsulfanyl)-phenyl


1535.
cyclopropylmethyl
4-(difluoromethylsulfanyl)-phenyl


1536.
cyclopropylmethyl
4-(trifluoromethylsulfanyl)-phenyl


1537.
cyclopropylmethyl
4-(methylsulfonyl)-phenyl


1538.
cyclopropylmethyl
4-(N-methoxy-N-methyl-amino)-phenyl


1539.
cyclopropylmethyl
4-(methoxyamino)-phenyl


1540.
cyclopropylmethyl
4-(ethoxyamino)-phenyl


1541.
cyclopropylmethyl
4-(N-methylaminooxy)-phenyl


1542.
cyclopropylmethyl
4-(N,N-dimethylaminooxy)-phenyl


1543.
cyclopropylmethyl
4-(azetidin-1-yl)-phenyl


1544.
cyclopropylmethyl
4-(2-methylazetidin-1-yl)-phenyl


1545.
cyclopropylmethyl
4-((S)-2-methylazetidin-1-yl)-phenyl


1546.
cyclopropylmethyl
4-((R)-2-methylazetidin-1-yl)-phenyl


1547.
cyclopropylmethyl
4-(3-fluoroazetidin-1-yl)-phenyl


1548.
cyclopropylmethyl
4-(3-methoxyazetidin-1-yl)-phenyl


1549.
cyclopropylmethyl
4-(3-hydroxyazetidin-1-yl)-phenyl


1550.
cyclopropylmethyl
4-(pyrrolidin-1-yl)-phenyl


1551.
cyclopropylmethyl
4-(pyrrolidin-2-yl)-phenyl


1552.
cyclopropylmethyl
4-((S)-pyrrolidin-2-yl)-phenyl


1553.
cyclopropylmethyl
4-((R)-pyrrolidin-2-yl)-phenyl


1554.
cyclopropylmethyl
4-(pyrrolidin-3-yl)-phenyl


1555.
cyclopropylmethyl
4-((S)-pyrrolidin-3-yl)-phenyl


1556.
cyclopropylmethyl
4-((R)-pyrrolidin-3-yl)-phenyl


1557.
cyclopropylmethyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


1558.
cyclopropylmethyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


1559.
cyclopropylmethyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


1560.
cyclopropylmethyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


1561.
cyclopropylmethyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


1562.
cyclopropylmethyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


1563.
cyclopropylmethyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


1564.
cyclopropylmethyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


1565.
cyclopropylmethyl
4-(2-methylpyrrolidin-1-yl)-phenyl


1566.
cyclopropylmethyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


1567.
cyclopropylmethyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


1568.
cyclopropylmethyl
4-(3-methylpyrrolidin-1-yl)-phenyl


1569.
cyclopropylmethyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


1570.
cyclopropylmethyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


1571.
cyclopropylmethyl
4-(1-methylpyrrolidin-2-yl)-phenyl


1572.
cyclopropylmethyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


1573.
cyclopropylmethyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


1574.
cyclopropylmethyl
4-(1-methylpyrrolidin-3-yl)-phenyl


1575.
cyclopropylmethyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


1576.
cyclopropylmethyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


1577.
cyclopropylmethyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


1578.
cyclopropylmethyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


1579.
cyclopropylmethyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


1580.
cyclopropylmethyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1581.
cyclopropylmethyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1582.
cyclopropylmethyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


1583.
cyclopropylmethyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1584.
cyclopropylmethyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1585.
cyclopropylmethyl
4-(2-oxopyrrolidin-1-yl)-phenyl


1586.
cyclopropylmethyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


1587.
cyclopropylmethyl
4-(piperidin-1-yl)-phenyl


1588.
cyclopropylmethyl
4-(2-methylpiperidin-1-yl)-phenyl


1589.
cyclopropylmethyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


1590.
cyclopropylmethyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


1591.
cyclopropylmethyl
4-(piperazin-1-yl)-phenyl


1592.
cyclopropylmethyl
4-(4-methylpiperazin-1-yl)-phenyl


1593.
cyclopropylmethyl
4-(morpholin-4-yl)-phenyl


1594.
cyclopropylmethyl
4-(thiomorpholin-4-yl)-phenyl


1595.
cyclopropylmethyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


1596.
cyclopropylmethyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


1597.
cyclopropylmethyl
4-(pyrrol-1-yl)-phenyl


1598.
cyclopropylmethyl
4-(pyrrol-2-yl)-phenyl


1599.
cyclopropylmethyl
4-(pyrrol-3-yl)-phenyl


1600.
cyclopropylmethyl
4-(1-methylpyrrol-2-yl)-phenyl


1601.
cyclopropylmethyl
4-(1-methylpyrrol-3-yl)-phenyl


1602.
cyclopropylmethyl
4-(furan-2-yl)-phenyl


1603.
cyclopropylmethyl
4-(furan-3-yl)-phenyl


1604.
cyclopropylmethyl
4-(thiophen-2-yl)-phenyl


1605.
cyclopropylmethyl
4-(thiophen-3-yl)-phenyl


1606.
cyclopropylmethyl
4-(5-propylthien-2-yl)-phenyl


1607.
cyclopropylmethyl
4-(pyrazol-1-yl)-phenyl


1608.
cyclopropylmethyl
4-(pyrazol-3-yl)-phenyl


1609.
cyclopropylmethyl
4-(pyrazol-4-yl)-phenyl


1610.
cyclopropylmethyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


1611.
cyclopropylmethyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


1612.
cyclopropylmethyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


1613.
cyclopropylmethyl
4-(1H-imidazol-2-yl)-phenyl


1614.
cyclopropylmethyl
4-(imidazol-1-yl)-phenyl


1615.
cyclopropylmethyl
4-(1-methylimidazol-2-yl)-phenyl


1616.
cyclopropylmethyl
4-(oxazol-2-yl)-phenyl


1617.
cyclopropylmethyl
4-(oxazol-4-yl)-phenyl


1618.
cyclopropylmethyl
4-(oxazol-5-yl)-phenyl


1619.
cyclopropylmethyl
4-(isoxazol-3-yl)-phenyl


1620.
cyclopropylmethyl
4-(isoxazol-4-yl)-phenyl


1621.
cyclopropylmethyl
4-(isoxazol-5-yl)-phenyl


1622.
cyclopropylmethyl
4-([1,2,3]-triazol-1-yl)-phenyl


1623.
cyclopropylmethyl
4-([1,2,4]-triazol-1-yl)-phenyl


1624.
cyclopropylmethyl
4-([1,2,3]-triazol-2-yl)-phenyl


1625.
cyclopropylmethyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


1626.
cyclopropylmethyl
4-([1,2,4]-triazol-4-yl)-phenyl


1627.
cyclopropylmethyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


1628.
cyclopropylmethyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


1629.
cyclopropylmethyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


1630.
cyclopropylmethyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


1631.
cyclopropylmethyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


1632.
cyclopropylmethyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


1633.
cyclopropylmethyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


1634.
cyclopropylmethyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


1635.
cyclopropylmethyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


1636.
cyclopropylmethyl
4-(1H-tetrazol-5-yl)-phenyl


1637.
cyclopropylmethyl
4-(tetrazol-1-yl)-phenyl


1638.
cyclopropylmethyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


1639.
cyclopropylmethyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


1640.
cyclopropylmethyl
4-furazan-3-yl-phenyl


1641.
cyclopropylmethyl
4-(pyrid-2-yl)-phenyl


1642.
cyclopropylmethyl
4-(pyrid-3-yl)-phenyl


1643.
cyclopropylmethyl
4-(pyrid-4-yl)-phenyl


1644.
cyclopropylmethyl
4-(pyrimidin-2-yl)-phenyl


1645.
cyclopropylmethyl
4-(pyrimidin-4-yl)-phenyl


1646.
cyclopropylmethyl
4-(pyrimidin-5-yl)-phenyl


1647.
cyclopropylmethyl
5-isopropylthiophen-2-yl


1648.
cyclopropylmethyl
2-chlorothiophen-5-yl


1649.
cyclopropylmethyl
2,5-dichlorothiophen-4-yl


1650.
cyclopropylmethyl
2,3-dichlorothiophen-5-yl


1651.
cyclopropylmethyl
2-chloro-3-nitrothiophen-5-yl


1652.
cyclopropylmethyl
2-(phenylsulfonyl)-thiophen-5-yl


1653.
cyclopropylmethyl
2-(pyridin-2-yl)thiophen-5-yl


1654.
cyclopropylmethyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


1655.
cyclopropylmethyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


1656.
cyclopropylmethyl
1-methyl-1H-imidazol-4-yl


1657.
cyclopropylmethyl
1,2-dimethyl-1H-imidazol-4-yl


1658.
cyclopropylmethyl
3,5-dimethylisoxazol-4-yl


1659.
cyclopropylmethyl
thiazol-2-yl


1660.
cyclopropylmethyl
4-methylthiazol-2-yl


1661.
cyclopropylmethyl
4-isopropylthiazol-2-yl


1662.
cyclopropylmethyl
4-trifluoromethylthiazol-2-yl


1663.
cyclopropylmethyl
5-methylthiazol-2-yl


1664.
cyclopropylmethyl
5-isopropylthiazol-2-yl


1665.
cyclopropylmethyl
5-trifluoromethylthiazol-2-yl


1666.
cyclopropylmethyl
2,4-dimethylthiazol-5-yl


1667.
cyclopropylmethyl
2-acetamido-4-methylthiazol-5-yl


1668.
cyclopropylmethyl
4H-[1,2,4]triazol-3-yl


1669.
cyclopropylmethyl
5-methyl-4H-[1,2,4]triazol-3-yl


1670.
cyclopropylmethyl
4-methyl-4H-[1,2,4]triazol-3-yl


1671.
cyclopropylmethyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


1672.
cyclopropylmethyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


1673.
cyclopropylmethyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


1674.
cyclopropylmethyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


1675.
cyclopropylmethyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


1676.
cyclopropylmethyl
[1,3,4]thiadiazol-2-yl


1677.
cyclopropylmethyl
5-methyl-[1,3,4]thiadiazol-2-yl


1678.
cyclopropylmethyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


1679.
cyclopropylmethyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


1680.
cyclopropylmethyl
3-bromo-2-chloropyrid-5-yl


1681.
cyclopropylmethyl
2-(4-morpholino)-pyrid-5-yl


1682.
cyclopropylmethyl
2-phenoxypyrid-5-yl


1683.
cyclopropylmethyl
(2-isopropyl)-pyrimidin-5-yl


1684.
cyclopropylmethyl
(5-isopropyl)-pyrimidin-2-yl


1685.
cyclopropylmethyl
8-quinolyl


1686.
cyclopropylmethyl
5-isoquinolyl


1687.
cyclopropylmethyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


1688.
cyclopropylmethyl
5-chloro-3-methylbenzothiophen-2-yl


1689.
cyclopropylmethyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


1690.
cyclopropylmethyl
benzothiazol-6-yl


1691.
cyclopropylmethyl
benzo[2,1,3]oxadiazol-4-yl


1692.
cyclopropylmethyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


1693.
cyclopropylmethyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


1694.
cyclopropylmethyl
benzo[2,1,3]thiadiazol-4-yl


1695.
allyl
4-methylphenyl


1696.
allyl
4-ethylphenyl


1697.
allyl
4-propylphenyl


1698.
allyl
4-isopropylphenyl


1699.
allyl
4-sec-butylphenyl


1700.
allyl
4-isobutylphenyl


1701.
allyl
4-(1,1-dimethylpropyl)-phenyl


1702.
allyl
4-vinylphenyl


1703.
allyl
4-isopropenylphenyl


1704.
allyl
4-fluorophenyl


1705.
allyl
4-chlorophenyl


1706.
allyl
4-bromophenyl


1707.
allyl
4-(fluoromethyl)phenyl


1708.
allyl
3-(fluoromethyl)phenyl


1709.
allyl
2-(fluoromethyl)phenyl


1710.
allyl
4-(difluoromethyl)phenyl


1711.
allyl
3-(difluoromethyl)phenyl


1712.
allyl
2-(difluoromethyl)phenyl


1713.
allyl
4-(trifluoromethyl)phenyl


1714.
allyl
3-(trifluoromethyl)phenyl


1715.
allyl
2-(trifluoromethyl)phenyl


1716.
allyl
4-(1-fluoroethyl)-phenyl


1717.
allyl
4-((S)-1-fluoroethyl)-phenyl


1718.
allyl
4-((R)-1-fluoroethyl)-phenyl


1719.
allyl
4-(2-fluoroethyl)-phenyl


1720.
allyl
4-(1,1-difluoroethyl)-phenyl


1721.
allyl
4-(2,2-difluoroethyl)-phenyl


1722.
allyl
4-(2,2,2-trifluoroethyl)-phenyl


1723.
allyl
4-(3-fluoropropyl)-phenyl


1724.
allyl
4-(2-fluoropropyl)-phenyl


1725.
allyl
4-((S)-2-fluoropropyl)-phenyl


1726.
allyl
4-((R)-2-fluoropropyl)-phenyl


1727.
allyl
4-(3,3-difluoropropyl)-phenyl


1728.
allyl
4-(3,3,3-trifluoropropyl)-phenyl


1729.
allyl
4-(1-fluoro-1-methylethyl)-phenyl


1730.
allyl
4-(2-fluoro-1-methylethyl)-phenyl


1731.
allyl
4-((S)-2-fluoro-1-methylethyl)-phenyl


1732.
allyl
4-((R)-2-fluoro-1-methylethyl)-phenyl


1733.
allyl
4-(2,2-difluoro-1-methylethyl)-phenyl


1734.
allyl
4-((S)-2,2-difluoro-1-methylethyl)-phenyl


1735.
allyl
4-((R)-2,2-difluoro-1-methylethyl)-phenyl


1736.
allyl
4-(2,2,2-trifluoro-1-methylethyl)-phenyl


1737.
allyl
4-((S)-2,2,2-trifluoro-1-methylethyl)-phenyl


1738.
allyl
4-((R)-2,2,2-trifluoro-1-methylethyl)-phenyl


1739.
allyl
4-(2-fluoro-1-fluoromethylethyl)-phenyl


1740.
allyl
4-(1-difluoromethyl-2,2-difluoroethyl)-




phenyl


1741.
allyl
4-(1,1-dimethyl-2-fluoroethyl)-phenyl


1742.
allyl
4-methoxyphenyl


1743.
allyl
4-ethoxyphenyl


1744.
allyl
4-propoxyphenyl


1745.
allyl
4-isopropoxyphenyl


1746.
allyl
4-butoxyphenyl


1747.
allyl
4-(fluoromethoxy)-phenyl


1748.
allyl
4-(difluoromethoxy)-phenyl


1749.
allyl
4-(trifluoromethoxy)-phenyl


1750.
allyl
3-(trifluoromethoxy)-phenyl


1751.
allyl
4-(2-fluoroethoxy)-phenyl


1752.
allyl
4-(2,2-difluoroethoxy)-phenyl


1753.
allyl
4-(2,2,2-trifluoroethoxy)-phenyl


1754.
allyl
4-(1,1,2,2-tetrafluoroethoxy)-phenyl


1755.
allyl
4-cyclopropylphenyl


1756.
allyl
4-cyclobutylphenyl


1757.
allyl
4-cyclopentylphenyl


1758.
allyl
4-(2,2-difluorocyclopropyl)-phenyl


1759.
allyl
3,4-difluorophenyl


1760.
allyl
4-bromo-3-fluorophenyl


1761.
allyl
4-bromo-2-fluorophenyl


1762.
allyl
4-bromo-2,5-difluorophenyl


1763.
allyl
2-fluoro-4-isopropylphenyl


1764.
allyl
3-fluoro-4-isopropylphenyl


1765.
allyl
4-(1-hydroxy-1-methylethyl)-phenyl


1766.
allyl
4-(2-hydroxy-2-methylpropyl)-phenyl


1767.
allyl
4-acetylphenyl


1768.
allyl
4-carboxyphenyl


1769.
allyl
4-cyanophenyl


1770.
allyl
4-hydroxyphenyl


1771.
allyl
4-(O-benzyl)-phenyl


1772.
allyl
4-(2-methoxyethoxy)-phenyl


1773.
allyl
4-(CH2—N(CH3)2)-phenyl


1774.
allyl
4-(NH—CO—NH2)-phenyl


1775.
allyl
4-(methylsulfanyl)-phenyl


1776.
allyl
4-(fluoromethylsulfanyl)-phenyl


1777.
allyl
4-(difluoromethylsulfanyl)-phenyl


1778.
allyl
4-(trifluoromethylsulfanyl)-phenyl


1779.
allyl
4-(methylsulfonyl)-phenyl


1780.
allyl
4-(N-methoxy-N-methyl-amino)-phenyl


1781.
allyl
4-(methoxyamino)-phenyl


1782.
allyl
4-(ethoxyamino)-phenyl


1783.
allyl
4-(N-methylaminooxy)-phenyl


1784.
allyl
4-(N,N-dimethylaminooxy)-phenyl


1785.
allyl
4-(azetidin-1-yl)-phenyl


1786.
allyl
4-(2-methylazetidin-1-yl)-phenyl


1787.
allyl
4-((S)-2-methylazetidin-1-yl)-phenyl


1788.
allyl
4-((R)-2-methylazetidin-1-yl)-phenyl


1789.
allyl
4-(3-fluoroazetidin-1-yl)-phenyl


1790.
allyl
4-(3-methoxyazetidin-1-yl)-phenyl


1791.
allyl
4-(3-hydroxyazetidin-1-yl)-phenyl


1792.
allyl
4-(pyrrolidin-1-yl)-phenyl


1793.
allyl
4-(pyrrolidin-2-yl)-phenyl


1794.
allyl
4-((S)-pyrrolidin-2-yl)-phenyl


1795.
allyl
4-((R)-pyrrolidin-2-yl)-phenyl


1796.
allyl
4-(pyrrolidin-3-yl)-phenyl


1797.
allyl
4-((S)-pyrrolidin-3-yl)-phenyl


1798.
allyl
4-((R)-pyrrolidin-3-yl)-phenyl


1799.
allyl
4-(2-fluoropyrrolidin-1-yl)-phenyl


1800.
allyl
4-((S)-2-fluoropyrrolidin-1-yl)-phenyl


1801.
allyl
4-((R)-2-fluoropyrrolidin-1-yl)-phenyl


1802.
allyl
4-(3-fluoropyrrolidin-1-yl)-phenyl


1803.
allyl
4-((S)-3-fluoropyrrolidin-1-yl)-phenyl


1804.
allyl
4-((R)-3-fluoropyrrolidin-1-yl)-phenyl


1805.
allyl
4-(2,2-difluoropyrrolidin-1-yl)-phenyl


1806.
allyl
4-(3,3-difluoropyrrolidin-1-yl)-phenyl


1807.
allyl
4-(2-methylpyrrolidin-1-yl)-phenyl


1808.
allyl
4-((S)-2-methylpyrrolidin-1-yl)-phenyl


1809.
allyl
4-((R)-2-methylpyrrolidin-1-yl)-phenyl


1810.
allyl
4-(3-methylpyrrolidin-1-yl)-phenyl


1811.
allyl
4-((S)-3-methylpyrrolidin-1-yl)-phenyl


1812.
allyl
4-((R)-3-methylpyrrolidin-1-yl)-phenyl


1813.
allyl
4-(1-methylpyrrolidin-2-yl)-phenyl


1814.
allyl
4-((S)-1-methylpyrrolidin-2-yl)-phenyl


1815.
allyl
4-((R)-1-methylpyrrolidin-2-yl)-phenyl


1816.
allyl
4-(1-methylpyrrolidin-3-yl)-phenyl


1817.
allyl
4-((S)-1-methylpyrrolidin-3-yl)-phenyl


1818.
allyl
4-((R)-1-methylpyrrolidin-3-yl)-phenyl


1819.
allyl
4-(2,2-dimethylpyrrolidin-1-yl)-phenyl


1820.
allyl
4-(3,3-dimethylpyrrolidin-1-yl)-phenyl


1821.
allyl
4-(2-trifluoromethylpyrrolidin-1-yl)-phenyl


1822.
allyl
4-((S)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1823.
allyl
4-((R)-2-trifluoromethylpyrrolidin-1-yl)-




phenyl


1824.
allyl
4-(3-trifluoromethylpyrrolidin-1-yl)-phenyl


1825.
allyl
4-((S)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1826.
allyl
4-((R)-3-trifluoromethylpyrrolidin-1-yl)-




phenyl


1827.
allyl
4-(2-oxopyrrolidin-1-yl)-phenyl


1828.
allyl
4-(2-oxo-oxazolidin-3-yl)-phenyl


1829.
allyl
4-(piperidin-1-yl)-phenyl


1830.
allyl
4-(2-methylpiperidin-1-yl)-phenyl


1831.
allyl
4-((S)-2-methylpiperidin-1-yl)-phenyl


1832.
allyl
4-((R)-2-methylpiperidin-1-yl)-phenyl


1833.
allyl
4-(piperazin-1-yl)-phenyl


1834.
allyl
4-(4-methylpiperazin-1-yl)-phenyl


1835.
allyl
4-(morpholin-4-yl)-phenyl


1836.
allyl
4-(thiomorpholin-4-yl)-phenyl


1837.
allyl
4-(1-oxo-thiomorpholin-4-yl)-phenyl


1838.
allyl
4-(1,1-dioxo-thiomorpholin-4-yl)-phenyl


1839.
allyl
4-(pyrrol-1-yl)-phenyl


1840.
allyl
4-(pyrrol-2-yl)-phenyl


1841.
allyl
4-(pyrrol-3-yl)-phenyl


1842.
allyl
4-(1-methylpyrrol-2-yl)-phenyl


1843.
allyl
4-(1-methylpyrrol-3-yl)-phenyl


1844.
allyl
4-(furan-2-yl)-phenyl


1845.
allyl
4-(furan-3-yl)-phenyl


1846.
allyl
4-(thiophen-2-yl)-phenyl


1847.
allyl
4-(thiophen-3-yl)-phenyl


1848.
allyl
4-(5-propylthien-2-yl)-phenyl


1849.
allyl
4-(pyrazol-1-yl)-phenyl


1850.
allyl
4-(pyrazol-3-yl)-phenyl


1851.
allyl
4-(pyrazol-4-yl)-phenyl


1852.
allyl
4-(1-methyl-1H-pyrazol-4-yl)-phenyl


1853.
allyl
4-(1-ethyl-1H-pyrazol-4-yl)-phenyl


1854.
allyl
4-(1-methyl-1H-pyrazol-5-yl)-phenyl


1855.
allyl
4-(1H-imidazol-2-yl)-phenyl


1856.
allyl
4-(imidazol-1-yl)-phenyl


1857.
allyl
4-(1-methylimidazol-2-yl)-phenyl


1858.
allyl
4-(oxazol-2-yl)-phenyl


1859.
allyl
4-(oxazol-4-yl)-phenyl


1860.
allyl
4-(oxazol-5-yl)-phenyl


1861.
allyl
4-(isoxazol-3-yl)-phenyl


1862.
allyl
4-(isoxazol-4-yl)-phenyl


1863.
allyl
4-(isoxazol-5-yl)-phenyl


1864.
allyl
4-([1,2,3]-triazol-1-yl)-phenyl


1865.
allyl
4-([1,2,4]-triazol-1-yl)-phenyl


1866.
allyl
4-([1,2,3]-triazol-2-yl)-phenyl


1867.
allyl
4-(4H-[1,2,4]-triazol-3-yl)-phenyl


1868.
allyl
4-([1,2,4]-triazol-4-yl)-phenyl


1869.
allyl
4-(2H-[1,2,3]-triazol-4-yl)-phenyl


1870.
allyl
4-(4-methyl-4H-[1,2,4]-triazol-3-yl)-phenyl


1871.
allyl
4-(2-methyl-2H-[1,2,3]-triazol-4-yl)-phenyl


1872.
allyl
4-([1,3,4]-oxadiazol-2-yl)-phenyl


1873.
allyl
4-([1,2,4]-oxadiazol-3-yl)-phenyl


1874.
allyl
4-([1,2,4]-oxadiazol-5-yl)-phenyl


1875.
allyl
4-([1,2,3]-oxadiazol-4-yl)-phenyl


1876.
allyl
4-([1,2,3]-oxadiazol-5-yl)-phenyl


1877.
allyl
4-([1,2,3]-thiadiazol-4-yl)-phenyl


1878.
allyl
4-(1H-tetrazol-5-yl)-phenyl


1879.
allyl
4-(tetrazol-1-yl)-phenyl


1880.
allyl
4-(2-methyl-2H-tetrazol-5-yl)-phenyl


1881.
allyl
4-(1-methyl-1H-tetrazol-5-yl)-phenyl


1882.
allyl
4-furazan-3-yl-phenyl


1883.
allyl
4-(pyrid-2-yl)-phenyl


1884.
allyl
4-(pyrid-3-yl)-phenyl


1885.
allyl
4-(pyrid-4-yl)-phenyl


1886.
allyl
4-(pyrimidin-2-yl)-phenyl


1887.
allyl
4-(pyrimidin-4-yl)-phenyl


1888.
allyl
4-(pyrimidin-5-yl)-phenyl


1889.
allyl
5-isopropylthiophen-2-yl


1890.
allyl
2-chlorothiophen-5-yl


1891.
allyl
2,5-dichlorothiophen-4-yl


1892.
allyl
2,3-dichlorothiophen-5-yl


1893.
allyl
2-chloro-3-nitrothiophen-5-yl


1894.
allyl
2-(phenylsulfonyl)-thiophen-5-yl


1895.
allyl
2-(pyridin-2-yl)thiophen-5-yl


1896.
allyl
2-(5-(trifluoromethyl)isoxazol-3-yl)-




thiophen-5-yl


1897.
allyl
2-(2-methylthiazol-4-yl)-thiophen-5-yl


1898.
allyl
1-methyl-1H-imidazol-4-yl


1899.
allyl
1,2-dimethyl-1H-imidazol-4-yl


1900.
allyl
3,5-dimethylisoxazol-4-yl


1901.
allyl
thiazol-2-yl


1902.
allyl
4-methylthiazol-2-yl


1903.
allyl
4-isopropylthiazol-2-yl


1904.
allyl
4-trifluoromethylthiazol-2-yl


1905.
allyl
5-methylthiazol-2-yl


1906.
allyl
5-isopropylthiazol-2-yl


1907.
allyl
5-trifluoromethylthiazol-2-yl


1908.
allyl
2,4-dimethylthiazol-5-yl


1909.
allyl
2-acetamido-4-methylthiazol-5-yl


1910.
allyl
4H-[1,2,4]triazol-3-yl


1911.
allyl
5-methyl-4H-[1,2,4]triazol-3-yl


1912.
allyl
4-methyl-4H-[1,2,4]triazol-3-yl


1913.
allyl
5-isopropyl-4H-[1,2,4]triazol-3-yl


1914.
allyl
5-trifluoromethyl-4H-[1,2,4]triazol-3-yl


1915.
allyl
4,5-dimethyl-4H-[1,2,4]triazol-3-yl


1916.
allyl
5-isopropyl-4-methyl-4H-[1,2,4]triazol-3-yl


1917.
allyl
5-trifluoromethyl-4-methyl-4H-




[1,2,4]triazol-3-yl


1918.
allyl
[1,3,4]thiadiazol-2-yl


1919.
allyl
5-methyl-[1,3,4]thiadiazol-2-yl


1920.
allyl
5-isopropyl-[1,3,4]thiadiazol-2-yl


1921.
allyl
5-trifluoromethyl-[1,3,4]thiadiazol-2-yl


1922.
allyl
3-bromo-2-chloropyrid-5-yl


1923.
allyl
2-(4-morpholino)-pyrid-5-yl


1924.
allyl
2-phenoxypyrid-5-yl


1925.
allyl
(2-isopropyl)-pyrimidin-5-yl


1926.
allyl
(5-isopropyl)-pyrimidin-2-yl


1927.
allyl
8-quinolyl


1928.
allyl
5-isoquinolyl


1929.
allyl
2-(trifluoroacetyl)-1,2,3,4-




tetrahydroisoquinolin-7-yl


1930.
allyl
5-chloro-3-methylbenzothiophen-2-yl


1931.
allyl
3,4-dihydro-4-methyl-2H-




benzo[b][1,4]oxazinyl


1932.
allyl
benzothiazol-6-yl


1933.
allyl
benzo[2,1,3]oxadiazol-4-yl


1934.
allyl
5-chlorobenzo[2,1,3]oxadiazol-4-yl


1935.
allyl
7-chlorobenzo[2,1,3]oxadiazol-4-yl


1936.
allyl
benzo[2,1,3]thiadiazol-4-yl


1937.
allyl
6-chloroimidazo[2,1-b]thiazolyl









The compounds of the formula I where E is NH and R1a is hydrogen can be prepared by analogy to methods which are well known in the art, e.g. from the international patent applications cited in the introductory part. A preferred method for the preparation of compounds I is outlined in scheme 1:




In scheme 1, R1, X, Y and Ar have the meanings as given above. R′ and R′′ are both hydrogen or together with the carbon atom form a carbonyl group. R has one of the meanings given for R1 or may be an amino-protecting group PG such as benzyl or tert.-butoxycarbonyl. Other suitable amino-protecting groups are disclosed, for example, in P. Kocienski, Protecting Groups, Thieme-Verlag, Stuttgart 2000, Chapter 6.
In step a) of scheme 1, compound II is reacted with an arylsulfonylchloride Cl—SO2—Ar, preferably in the presence of a base, according to standard procedures in the art. The reaction depicted in scheme 1 step a) takes place under the reaction conditions which are customary for preparing arylsulfonamide compounds or arylsulfonic esters, respectively, and which are described, for example, in J. March, Advanced Organic Chemistry, 3rd edition, John Wiley & Sons, New York, 1985 p 444 and the literature cited therein, European J. Org. Chem. 2002 (13), pp. 2094-2108, Tetrahedron 2001, 57 (27) pp. 5885-5895, Bioorganic and Medicinal Chemistry Letters, 2000, 10(8), pp. 835-838 and Synthesis 2000 (1), pp. 103-108. The reaction customarily takes place in an inert solvent, for example in an ether, such as diethyl ether, diisopropyl ether, methyl tert-butyl ether or tetrahydrofuran, a halohydrocarbon, such as dichloromethane, an aliphatic or cycloaliphatic hydrocarbon, such as pentane, hexane or cyclohexane, or an aromatic hydrocarbon, such as toluene, xylene, cumene and the like, or in a mixture of the abovementioned solvents. The reaction of II with Cl—SO2—Ar is customarily carried out in the presence of an auxiliary base. Suitable bases are inorganic bases, such as sodium carbonate or potassium carbonate, or sodium hydrogen carbonate or potassium hydrogen carbonate, and organic bases, for example trialkylamines, such as triethylamine, or pyridine compounds, such as pyridine, lutidine and the like. The latter compounds can at the same time serve as solvents. The auxiliary base is customarily employed in at least equimolar quantities, based on the amine compound II.
The obtained compound Ia, corresponds to compound I, if R′ and R′′ are both hydrogen and R is R1. If R′ and R′′ represent a carbonyl group, this group will be reduced in step b) of scheme 1 by analogy to known methods, e.g. by reduction with borane, boranedimethylsulfide or by a complex hydride such as lithium aliuminiumhydride.
If R is an amino protecting group PG, this group can be cleaved by standard methods to obtain the primary amine (see P. Kocienski, Protecting Groups, loc. cit.). This primary amine can be reacted in the sense of an alkylation, with a compound R1—X. In this compound, R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-alkenyl, and X is a nucleophilically displaceable leaving group, e.g. halogen, trifluoroacetate, alkylsulfonate, arylsulfonate, alkyl sulfate and the like. The reaction conditions which are required for the alkylation have been adequately disclosed, e.g. in Bioorganic and Medicinal Chemistry Lett. 2002, 12(7), pp. 2443-2446 and also 2002, 12(5), pp. 1917-1919.
In case R1 in formula I is hydrogen, compound I or Ia can also be reacted with an acyl halide to obtain a compound of the formula I wherein R1 is C1-C3-alkylcarbonyl. The carbonyl group in these compounds can be reduced with diborane to obtain compounds of the general formula I, wherein R1 is C2-C4-alkyl. The carbonyl group can also be reacted with a fluorinating agent to obtain a compound I wherein R1 is 1,1-difluoroalkyl. Acylation and reduction can be achieved by standard methods, which are discussed in J. March, Advanced Organic Chemistry, 3rd ed. J. Wiley & Sons, New York 1985, p. 370 and 373 (acylation) and p. 1099 f. and in the literature cited in this publication (with regard to acylation, see also Synth. Commun. 1986, 16, p. 267, and with regard to reduction, see also J. Heterocycl. Chem. 1979, 16, p. 1525).
The introduction of C2-C4-alkyl or fluorinated C2-C4-alkyl as a radical R1 into a compound of formula I, wherein both R1 and R1a are hydrogen, can also be achieved, in the sense of a reductive amination, by reacting I [R1═R1a═H] with a suitable ketone or aldehyde in the presence of a reducing agent, e.g. in the presence of a borohydride such as sodium borohydride, sodium cyanoborohydride or sodium triacetoxyborohydride. The skilled person is familiar with the reaction conditions which are required for a reductive amination, e.g. from Bioorganic and Medicinal Chemistry Lett. 2002, 12(5), pp. 795-798 and 12(7) pp. 1269-1273.
A skilled person will appreciate, that a compound I, wherein R1 is alkenyl can be converted into a compound wherein R1 is alkyl or fluorinated alkyl by hydrogenation or by addition of hydrogen fluoride or by fluorination with suitable fluorinating agents such as XeF2 or CoF3.
A skilled person will further appreciate, that a radical R3, which is different from hydrogen, can be introduced in either compound I of scheme I or at an earlier stage of the synthesis by a conventional alkylation.
In step a′) of scheme 1, a bromine compound III is reacted with an arylsulfonylamide Ar—SO2—NH2 in the presence of a palladium(O) compound such as tris(dibenzylideneacetone)-dipalladium(0) in the presence of a tri(substituted)phosphine, e.g. a triarylphosphine such as triphenylphosphine or tritolylphosphine, tri(cyclo)alkylphosphine such as tris-n-butylphosphine, tris(tert.-butyl)phosphine or tris(cyclohexyl)phosphine, preferably in the presence of a base such as sodium hydride according to the method described in J. Org. Chem., 68 (2993) pp 8274-8276, and outlined below. Thereby a compound la is obtained which can be reacted further as described above.
A skilled person will also appreciate, that the methods outlined in scheme 1, can also be applied in the synthesis of compounds I, wherein R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2 or 3.
The compounds of the formula I where E is CH2 and R1a is hydrogen can be prepared by analogy to methods which are well known in the art, e.g. from the international patent applications cited in the introductory part. A preferred method for the preparation of compounds I is outlined in scheme 2:




In scheme 2, R, R′, R′′, R1, Ar, X and Y have the meanings given above. According to scheme 2, compound IV is reacted in step a) with a mercapto compound HS—Ar in the presence of a base, such as sodium hydride or sodium alkoxide or with an alkali metal salt thereof thereby yielding thioether compound lb. The thioether moiety in compound is oxidized to a sulfone moiety, e.g. by oxone (step b). If R is a protective group, R can be cleaved, thereby obtaining compound I, wherein R1a is H. A skilled person understands that I can be further transformed as outlined for scheme 1.
A skilled person will also appreciate, that the methods outlined in scheme 2, can also be applied in the synthesis of compounds I, wherein R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2 or 3.
Compounds of the formula I, wherein E is NR3, X is N and Y is NH can also be prepared by the reaction sequence shown in scheme 3.




In scheme 3, R3 and Ar have the meanings given above. Rc is C1-C3-alkyl or fluorinated C1-C3-alkyl.
Step a) of scheme 3 can be performed according to the method described for step a) of scheme 1.
In step b), the nitro group in VI is reduced to the NH2 group in VII. The reaction conditions which are required for step b) correspond to the customary conditions for reducing aromatic nitro groups which have been described extensively in the literature (see, for example, J. March, Advanced Organic Chemistry, 3rd ed., J. Wiley & Sons, New-York, 1985, p. 1183 and the literature cited in this reference). The reduction is achieved, for example, by reacting the nitro compound VI with a metal such as iron, zinc or tin under acidic reaction conditions, i.e. using nascent hydrogen, or using a complex hydride such as lithium aluminum hydride or sodium borohydride, preferably in the presence of transition metal compounds of nickel or cobalt such as NiCl2(P(phenyl)3)2, or CoCl2, (see Ono et al. Chem. Ind. (London), 1983 p. 480), or using NaBH2S3 (see Lalancette et al. Can. J. Chem. 49, 1971, p. 2990), with it being possible to carry out these reductions, depending on the given reagent, in substance or in a solvent or diluent. Alternatively, the reduction of VI to VII can be carried out with hydrogen in the presence of a transition metal catalyst, e.g. using hydrogen in the presence of catalysts based on platinum, palladium, nickel, ruthenium or rhodium. The catalysts can contain the transition metal in elemental form or in the form of a complex compound, of a salt or of an oxide of the transition metal, with it being possible, for the purpose of modifying the activity, to use customary coligands, e.g. organic phosphine compounds, such as triphenylphosphine, tricyclohexylphosphine or tri-n-butylphosphine or phosphites. The catalyst is customarily employed in quantities of from 0.001 to 1 mol per mol of compound VI, calculated as catalyst metal. In a preferred variant, the reduction is effected using tin(II) chloride in analogy with the methods described in Bioorganic and Medicinal Chemistry Letters, 2002, 12(15), pp. 1917-1919 and J. Med. Chem. 2002, 45(21), pp. 4679-4688. The reaction of VI with tin(II) chloride is preferably carried out in an inert organic solvent, preferably an alcohol such as methanol, ethanol, isopropanol or butanol.
In step c) compound VII is reacted with an acylated derivative of glycine in the presence of a carbodiimide such as N′-(3-dimethylamino)propyl-N′-ethylcarbodiimid and optionally an organic buffer such as hydroxy-7-azabenzotriazole/tertiary amine such as diisopropylethylamine. Thereby a compound I is obtained, wherein R1 is C1-C3-alkylcarbonyl or fluorinated C1-C3-alkylcarbonyl. The carbonyl group in these compounds can be reduced to a CH2-moiety either with diborane, borane-dimethylsulfide or lithium aluminium hydride to obtain compounds of the general formula I, wherein R is CH2-(optionally fluorinated C1-C3-alkyl) (see e.g. see also J. Heterocycl. Chem. 1979, 16, p. 1525). The carbonyl group can also be reacted with a fluorinating agent to obtain a compound I wherein R1 is 1,1-difluoroalkyl. The optionally fluorinated C1-C3-alkylcarbonyl group can also be cleaved.
Compounds of the formula II, III, IV and V are known in the art. They can also be prepared by standard methods, e.g. by a nitration/reduction sequence (compounds II), by bromination of the aromatic core (compounds III) or by side chain bromination or by hydroxymethylation followed by OH/bromine exchange (compounds IV). Each of these methods may apply suitable protecting groups.
Compounds of the formula II, wherein XC(R)—Y form a saturated carbocycle can be obtained by the reaction sequences shown in the following schemes 4 and 5:




In scheme 4 Y′ is CH2 or CH2CH2. R is C1-C3-alkylcarbonyl or an amino-protecting group PG.
In step a) a one-pot reaction involving the addition of glycolic acid to ketone VIII, with subsequent dehydration in the presence of an acid such as sulphuric acid (J. Org. Chem. 1994, 37, 2071-2078), generates the requisite α,β-unsaturated ketone IX. Concomitant catalytic hydrogenation of the double bond and reduction of the keto-group in IX can be performed using a catalyst such as Pd—C (step b, J. Org. Chem. 1994, 37, 2071-2078). Conversion of the carboxylic acid X to the primary amine may XI be accomplished by reaction of DPPA in benzyl alcohol followed by catalytic hydrogenation using a catalyst such as Pd—C (step c, Bioorg. Med. Chem. Lett., 1999, 9(3), 401-406). In step d, the amine XI is acylated or protected as outlined for scheme 1. Subsequent nitration (step e) and reduction of the nitro group (as outlined for scheme 2) yields the desired amine II.




In scheme 5 X′ is absent, CH2 or CH2CH2, Y′ is CH2, CH2CH2 or CH2CH2CH2. R is C1-C3-alkylcarbonyl or an amino-protecting group PG.
According to scheme 5, compound XIV is converted into the mesylate by reacting XIV with mesylchloride in the presence of a tertiary amine such as diisopropylethylamine and optionally a catalyst such as dimethylaminophenol. The mesylate of XIV is then reacted with a cyanide such as tetraethylammonium cyanide to obtain the nitrile compound XV. The nitrile XV is then hydrogenated by suitable means, e.g. by a complex hydride such as lithium aluminiumhydride, thereby yielding the primary amine XIa, which can be converted into the amine II by analogy to scheme 4.
Compounds of the formula III, wherein XC(R)—Y form a saturated carbocycle can be obtained by the reaction sequences shown in the following scheme 6.




In scheme 6 X′ is absent, i.e. a single bond, or CH2 or CH2CH2, Y′ is CH2, CH2CH2 or CH2CH2CH2. R1 has the meanings as given above.
In step a) of scheme 6, the ketone XVI is reacted with trimethylsilylcyanide in the presence of a weak Lewis acid such as zinc iodide, whereby compound XVII is obtained. Compound XVII is then reacted with stannous(II) chloride in methanolic HCl, whereby the acid XVIII is obtained. The acid is then reacted with an amine R1—NH2 to obtain compound III.
A further approach to compounds I, wherein E is NH is shown in scheme 7.




In scheme 7, R1 is different from hydrogen. PG is a protective group, e.g. an acetyl group.
Starting from commercially available tryptoline (2,3,4,9-tetrahydro-1H-beta-carboline), a radical R1 is introduced either by alkylation or acylation as outlined for scheme 1. After protection of the indoline nitrogen, a nitration is performed according to Synthetic Communications (2003), 33, 3707-3716. The separation of the obtained isomers can be achieved by flash chromatography. Nitration and reduction to the amine can also be achieved according to the method described in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1991), 11, 1729-1734 and in Taiwan Yixuehui Zazki (1960), 59, 550-555. The amine is then reacted with Ar—SO2—Cl as described for scheme 1 and the obtained compound can be hydrogenated.
If not indicated otherwise, the above-described reactions are generally carried out in a solvent at temperatures between room temperature and the boiling temperature of the solvent employed. Alternatively, the activation energy which is required for the reaction can be introduced into the reaction mixture using microwaves, something which has proved to be of value, in particular, in the case of the reactions catalyzed by transition metals (with regard to reactions using microwaves, see Tetrahedron 2001, 57, p. 9199 ff. p. 9225 ff. and also, in a general manner, “Microwaves in Organic Synthesis”, André Loupy (Ed.), Wiley-VCH 2002).
The sulfonylchlorides Cl—SO2—Ar are either commercially available or can be prepared according to standard synthetic methods. Sulfonylchlorides containing a fluorinated radical Ra may be prepared by different synthetic routes, e.g. by reacting suitable hydroxy or oxo precursor (e.g. a compound Cl—SO2—Ar, carrying a hydroxy or oxo substituted radical) with fluorinating reagents like DAST (diethylaminosulfurtrifluoride), morpholine-DAST, deoxofluor (bis(2-methoxyethyl)aminosulfur trifluoride), Ishikawa's reagent (N,N-diethyl-(1,1,2,3,3,3-hexafluoropropyl)amine; Journal of Fluorine Chemistry, 1989, 43, 371-377). More conventionally, the hydroxy group of an aromatic compound which carries a hydroxy substituted radical but not a chlorosulfonyl group, is transformed into a leaving group which is then replaced by a fluoride ion (J. Org. Chem., 1994, 59, 2898-22901; Tetrahedron Letters, 1998, 7305-6; J. Org. Chem., 1998, 63, 9587-9589, Synthesis, 1987, 920-21)). Subsequent direct chlorosulfonylation with chlorosulfonic acid (Heterocycles, 2001, 55, 9, 1789-1803; J. Org. Chem., 2000, 65, 1399-1406) or a two step process preparing first the sulfonic acid derivatives which are then transformed to the sulfonylchlorides with e.g. chlorosulfonic acid, phosphorous pentachloride (Eur. J. Med. Chem., 2002, 36, 809-828) and the like, yields the desired sulfonylchloride (Tetrahedron Letters, 1991, 33,50 7787-7788)). Sulfonylchlorides may also be prepared by diazotization of suitable amine precursor Ar—NH2 with sodium nitrite under acidic conditions and reaction with sulfur dioxide in acetic acid (scheme (iii); J. Org. Chem., 1960, 25, 1824-26); by oxidation of suitable heteroaryl-thiols HS—Ar or heteroaryl-benzyl-thioethers C6H5—CH2—S—Ar with chlorine (Synthesis, 1998, 36-38; J. Am. Chem. Soc., 1950, 74, 4890-92) directly to the corresponding sulfonyl chlorides. The further are known in the art or may be prepared by standard methods. E.g. mercapto-pyrimidines or pyrimidinyl-benzylthioether precursors can be prepared according to literature (Chemische Berichte, 1960, 1208-11; Chemische Berichte, 1960, 95, 230-235; Collection Czechoslow. Chem. Comm., 1959, 24, 1667-1671; Austr. J. Chem., 1966, 19, 2321-30; Chemiker-Zeitung, 101, 6, 1977, 305-7; Tetrahedron, 2002, 58, 887-890; Synthesis, 1983, 641-645.
In the following schemes 8 to 10 several routes are shown which are suitable to prepare benzenesulfonyl chlorides carrying fluorinated propyl radical.




The 4-(1,1-difluoropropan-2-yl)benzene-1-sulfonyl chloride intermediate can be prepared from the commercially available 2-phenylpropanoic acid. In the first step a) the 2-phenylpropanic acid is converted to the alkyl ester by esterification with an alcohol (e.g. methanol or ethanol) under acid catalysis (e.g. HCl, SO2Cl2). The ester can be reduced to the corresponding 2-phenyl propanal by a reducing agent such as DIBAL (diisobutylaluminium hydride). The aldehyde is converted to the 1,1-difluoro-2-propyl derivative by reaction with a suitable fluorinating reagent like DAST (diethylaminosulfurtrifluoride), morpholine-DAST, deoxo-fluor (bis(2-methoxyethyl)aminosulfur trifluoride), Ishikawa's reagent (N,N-diethyl-(1,1,2,3,3,3-hexafluoropropyl)amine; Journal of Fluorine Chemistry, 1989, 43, 371-377) (step b). The thus obtained 1,1-difluoro-2-phenylpropane can be converted into 4-(1,1-difluoro-2-propyl)benzenesulfonyl chloride by either direct chlorosulfonylation with chlorosulfonic acid (Heterocycles, 2001, 55, 9, 1789-1803; J. Org. Chem., 2000, 65, 1399-1406) (step c) or by a two step process preparing first the sulfonic acid derivatives (step d) which are then transformed to the sulfonylchlorides (step e) by reaction with e.g. chlorosulfonic acid, phosphorous pentachloride (Eur. J. Med. Chem., 2002, 36, 809-828); through diazotisation of suitable amine precursors with sodium nitrite under acidic conditions and reaction with sulfur dioxide in acetic acid (J. Org. Chem., 1960, 25, 1824-26); oxidation of suitable heteroaryl-thiols or heteroaryl-benzyl-thioethers with chlorine (Synthesis, 1998, 36-38; J. Am. Chem. Soc., 1950, 74, 4890-92) directly to the corresponding sulfonyl chlorides.
The synthesis shown in scheme 8 can also be performed using (R)-2-phenylpropanic acid and (S)-2-phenylpropanic acid respectively to give the corresponding chiral 4-(1,1-difluoropropan-2-yl)benzene-1-sulfonyl chlorides.




4-(1,1,1-Trifluoropropan-2-yl)benzene-1-sulfonyl chloride intermediate can be prepared from the commercially available 2,2,2-trifluoro-1-phenylethanone by a synthetic route shown in scheme 9. The ketone can be converted to the 3,3,3-trifluoro-2-phenylpropene by a Wittig reaction with a suitable ylide such as methylene-triphenylphosphane (prepared by reaction of methyltriphenylphosphonium halide and a suitable base such as lithium diisopropylamide or potassium tert-butoxide) or according to a Horner-Emmons reaction by reacting the ketone with a suitable phosphonate such as diethyl methylphosphonate and a suitable base such as lithium diisopropylamide or potassium tert-butoxide. The thus obtained 3,3,3-trifluoro-2-phenylpropene can then be reduced to the saturated alkane by catalytic hydrogenation (eg Pd—C) followed by conversion to the sulfonyl chloride by the methods described in scheme 8.
The synthesis of scheme 9 can also be performed using a chiral catalyst for the alkene hydrogenation to allow the preparation of the corresponding chiral 4-(1,1,1-triifluoropropan-2-yl)benzene-1-sulfonyl chlorides.




The 4-(1,1,1-trifluoropropan-2-yl)benzene-1-sulfonyl chloride can be also prepared from the commercially available 1-phenyl-ethanone by a four step procedure as shown in scheme 10. The ketone can be converted to the trifluoromethyl hydroxyl intermediate by reaction with trimethyl-trifluoromethyl-silane (Journal of Organic Chemistry, 2000, 65, 8848-8856; Journal of Fluorine Chemistry, 2003, 122, 243-246) which can then be converted to the trifluoromethyl bromide (Journal of the American Chemical Society, 1987, 109, 2435-4). Dehalogenation by catalytic hydrogenation (eg Pd—C) can then be followed by conversion to the sulfonyl chloride by the methods discussed above.
Examples of solvents which can be used are ethers, such as diethyl ether, diisopropyl ether, methyl tert-butyl ether or tetrahydrofuran, aprotic polar solvent, such as dimethylformamide, dimethyl sulfoxide, dimethoxyethane, and acetonitrile, aromatic hydrocarbons, such as toluene and xylene, ketones, such as acetone or methyl ethyl ketone, halohydrocarbons, such as dichloromethane, trichloromethane and dichloroethane, esters, such as ethyl acetate and methyl butyrate, carboxylic acids, such as acetic acid or propionic acid, and alcohols, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, 2-butanol and tert.-butanol.
If desired, it is possible for a base to be present in order to neutralize protons which are released in the reactions. Suitable bases include inorganic bases, such as sodium carbonate, potassium carbonate, sodium hydrogen carbonate or potassium hydrogen carbonate, and, in addition, alkoxides, such as sodium methoxide or sodium ethoxide, alkali metal hydrides, such as sodium hydride, and also organometallic compounds, such as butyllithium compounds or alkylmagnesium compounds, or organic nitrogen bases, such as triethylamine or pyridine. The latter compounds can at the same time serve as solvents.
The crude product is isolated in a customary manner, for example by filtering, distilling off the solvent or extracting from the reaction mixture, etc. The resulting compounds can be purified in a customary manner, for example by means of recrystallizing from a solvent, by means of chromatography or by means of converting into an acid addition salt.
The acid addition salts are prepared in a customary manner by mixing the free base with a corresponding acid, where appropriate in solution in an organic solvent, for example a lower alcohol, such as methanol, ethanol or propanol, an ether, such as methyl tert-butyl ether or diisopropyl ether, a ketone, such as acetone or methyl ethyl ketone, or an ester, such as ethyl acetate.
The compounds according to the invention of the formula I are surprisingly highly selective dopamine D3 receptor ligands which, because of their low affinity for other receptors such as D1 receptors, D4 receptors, α1-adrenergic and/or α2-adrenergic receptors, muscarinergic receptors, histamine receptors, opiate receptors and, in particular, dopamine D2 receptors, give rise to fewer side-effects than do the classic neuroleptics, which are D2 receptor antagonists. A compound of the invention can be a dopamine D3 receptor agonist, including partial agonistic activity, or a dopamine D3 receptor antagonist, including partial antagonistic activity.
The high affinity of the compounds according to the invention for D3 receptors is reflected in very low in-vitro receptor binding constants (Ki(D3) values) of as a rule less than 50 nM (nmol/l), preferably of less than 10 nM and, in particular of less than 5 nM. The displacement of [125I]-iodosulpride can, for example, be used in receptor binding studies for determining binding affinities for D3 receptors.
The selectivity of the compounds according to the invention, i.e. the ratio Ki(D2)/Ki(D3) of the receptor binding constants, is as a rule at least 50, preferably at least 100, even better at least 150. The displacement of [3H]SCH23390, [125I] iodosulpride or [125I] spiperone can be used, for example, for carrying out receptor binding studies on D1, D2 and D4 receptors.
Because of their binding profile, the compounds can be used for treating diseases which respond to dopamine D3 receptor ligands (or which are susceptible to treatment with a dopamine D3 receptor ligand, respectively), i.e. they are effective for treating those medical disorders or diseases in which exerting an influence on (modulating) the dopamine D3 receptors leads to an improvement in the clinical picture or to the disease being cured. Examples of these diseases are disorders or diseases of the central nervous system.
Disorders or diseases of the central nervous system are understood as meaning disorders which affect the spinal chord and, in particular, the brain. Within the meaning of the invention, the term “disorder” denotes disturbances and/or anomalies which are as a rule regarded as being pathological conditions or functions and which can manifest themselves in the form of particular signs, symptoms and/or malfunctions. While the treatment according to the invention can be directed toward individual disorders, i.e. anomalies or pathological conditions, it is also possible for several anomalies, which may be causatively linked to each other, to be combined into patterns, i.e. syndromes, which can be treated in accordance with the invention.
The disorders which can be treated in accordance with the invention are, in particular, psychiatric and neurological disturbances. These disturbances include, in particular, organic disturbances, including symptomatic disturbances, such as psychoses of the acute exogenous reaction type or attendant psychoses of organic or exogenous cause, e.g., in association with metabolic disturbances, infections and endocrinopathogies; endogenous psychoses, such as schizophrenia and schizotype and delusional disturbances; affective disturbances, such as depressions, mania and/or manic-depressive conditions; and also mixed forms of the above-described disturbances; neurotic and somatoform disturbances and also disturbances in association with stress; dissociative disturbances, e.g. loss of consciousness, clouding of consciousness, double consciousness and personality disturbances; disturbances in attention and waking/sleeping behavior, such as behavioral disturbances and emotional disturbances whose onset lies in childhood and youth, e.g. hyperactivity in children, intellectual deficits, in particular attention disturbances (attention deficit disorders), memory disturbances and cognitive disturbances, e.g. impaired learning and memory (impaired cognitive function), dementia, narcolepsy and sleep disturbances, e.g. restless legs syndrome; development disturbances; anxiety states, delirium; sexlife disturbances, e.g. impotence in men; eating disturbances, e.g. anorexia or bulimia; addiction; and other unspecified psychiatric disturbances.
The disorders which can be treated in accordance with the invention also include Parkinson's disease and epilepsy and, in particular, the affective disturbances connected thereto.
The addiction diseases include psychic disorders and behavioral disturbances which are caused by the abuse of psychotropic substances, such as pharmaceuticals or narcotics, and also other addiction diseases, such as addiction to gaming (impulse control disorders not elsewhere classified). Examples of addictive substances are: opioids (e.g. morphine, heroin and codeine), cocaine; nicotine; alcohol; substances which interact with the GABA chloride channel complex, sedatives, hypnotics and tranquilizers, for example benzodiazepines; LSD; cannabinoids; psychomotor stimulants, such as 3,4-methylenedioxy-N-methylamphetamine, (ecstasy); amphetamine and amphetamine-like substances such as methylphenidate and other stimulants including caffeine. Addictive substances which come particularly into consideration are opioids, cocaine, amphetamine or amphetamine-like substances, nicotine and alcohol.
With regard to the treatment of addiction diseases, particular preference is given to those compounds according to the invention of the formula I which themselves do not possess any psychotropic effect. This can also be observed in a test using rats, which, after having been administered compounds which can be used in accordance with the invention, reduce their self administration of psychotropic substances, for example cocaine.
According to another aspect of the present invention, the compounds according to the invention are suitable for treating disorders whose causes can at least partially be attributed to an anomalous activity of dopamine D3 receptors.
According to another aspect of the present invention, the treatment is directed, in particular, toward those disorders which can be influenced, within the sense of an expedient medicinal treatment, by the binding of preferably exogeneously administered binding partners (ligands) to dopamine D3 receptors.
The diseases which can be treated with the compounds according to the invention are frequently characterized by progressive development, i.e. the above-described conditions change over the course of time; as a rule, the severity increases and conditions may possibly merge into each other or other conditions may appear in addition to those which already exist.
The compounds according to the invention can be used to treat a large number of signs, symptoms and/or malfunctions which are connected with the disorders of the central nervous system and, in particular, the abovementioned conditions. These signs, symptoms and/or malfunctions include, for example, a disturbed relationship to reality, lack of insight and ability to meet customary social norms or the demands made by life, changes in temperament, changes in individual drives, such as hunger, sleep, thirst, etc., and in mood, disturbances in the ability to observe and combine, changes in personality, in particular emotional liability, hallucinations, ego-disturbances, distractedness, ambivalence, autism, depersonalization and false perceptions, delusional ideas, chanting speech, lack of synkinesis, short-step gait, flexed posture of trunk and limbs, tremor, poverty of facial expression, monotonous speech, depressions, apathy, impeded spontaneity and decisiveness, impoverished association ability, anxiety, nervous agitation, stammering, social phobia, panic disturbances, withdrawal symptoms in association with dependency, maniform syndromes, states of excitation and confusion, dysphoria, dyskinetic syndromes and tic disorders, e.g. Huntington's chorea and Gilles-de-la-Tourette's syndrome, vertigo syndromes, e.g. peripheral positional, rotational and oscillatory vertigo, melancholia, hysteria, hypochondria and the like.
Within the meaning of the invention, a treatment also includes a preventive treatment (prophylaxis), in particular as relapse prophylaxis or phase prophylaxis, as well as the treatment of acute or chronic signs, symptoms and/or malfunctions. The treatment can be orientated symptomatically, for example as the suppression of symptoms. It can be effected over a short period, be orientated over the medium term or can be a long-term treatment, for example within the context of a maintenance therapy.
Therefore the compounds according to the invention are preferentially suitable for treating diseases of the central nervous system, in particular for treating affective disorders; neurotic disturbances, stress disturbances and somatoform disturbances and psychoses, and, in particular, for treating schizophrenia and depression. Because of their high selectivity with regard to the D3 receptor, the compounds I according to the invention are also suitable for treating disturbances of kidney function, in particular disturbances of kidney function which are caused by diabetes mellitus (see WO 00/67847) and, especially, diabetic nephropathy.
Within the context of the treatment, the use according to the invention of the described compounds involves a method. In this method, an effective quantity of one or more compounds, as a rule formulated in accordance with pharmaceutical and veterinary practice, is administered to the individual to be treated, preferably a mammal, in particular a human being, productive animal or domestic animal. Whether such a treatment is indicated, and in which form it is to take place, depends on the individual case and is subject to medical assessment (diagnosis) which takes into consideration signs, symptoms and/or malfunctions which are present, the risks of developing particular signs, symptoms and/or malfunctions, and other factors.
As a rule, the treatment is effected by means of single or repeated daily administration, where appropriate together, or alternating, with other active compounds or active compound-containing preparations such that a daily dose of preferably from about 0.1 to 1000 mg/kg of bodyweight, in the case of oral administration, or of from about 0.1 to 100 mg/kg of bodyweight, in the case of parenteral administration, is supplied to an individual to be treated.
The invention also relates to the production of pharmaceutical compositions for treating an individual, preferably a mammal, in particular a human being, productive animal or domestic animal. Thus, the ligands are customarily administered in the form of pharmaceutical compositions which comprise a pharmaceutically acceptable excipient together with at least one compound according to the invention and, where appropriate, other active compounds. These compositions can, for example, be administered orally, rectally, transdermally, subcutaneously, intravenously, intramuscularly or intranasally.
Examples of suitable pharmaceutical formulations are solid medicinal forms, such as powders, granules, tablets, in particular film tablets, lozenges, sachets, cachets, sugar-coated tablets, capsules, such as hard gelatin capsules and soft gelatin capsules, suppositories or vaginal medicinal forms, semisolid medicinal forms, such as ointments, creams, hydrogels, pastes or plasters, and also liquid medicinal forms, such as solutions, emulsions, in particular oil-in-water emulsions, suspensions, for example lotions, injection preparations and infusion preparations, and eyedrops and eardrops. Implanted release devices can also be used for administering inhibitors according to the invention. In addition, it is also possible to use liposomes or microspheres.
When producing the compositions, the compounds according to the invention are optionally mixed or diluted with one or more excipients. Excipients can be solid, semisolid or liquid materials which serve as vehicles, carriers or medium for the active compound.
Suitable excipients are listed in the specialist medicinal monographs. In addition, the formulations can comprise pharmaceutically acceptable carriers or customary auxiliary substances, such as glidants; wetting agents; emulsifying and suspending agents; preservatives; antioxidants; antiirritants; chelating agents; coating auxiliaries; emulsion stabilizers; film formers; gel formers; odor masking agents; taste corrigents; resin; hydrocolloids; solvents; solubilizers; neutralizing agents; diffusion accelerators; pigments; quaternary ammonium compounds; refatting and overfatting agents; raw materials for ointments, creams or oils; silicone derivatives; spreading auxiliaries; stabilizers; sterilants; suppository bases; tablet auxiliaries, such as binders, fillers, glidants, disintegrants or coatings; propellants; drying agents; opacifiers; thickeners; waxes; plasticizers and white-mineral oils. A formulation in this regard is based on specialist knowledge as described, for example, in Fiedler, H. P., Lexikon der Hilfsstoffe für Pharmazie, Kosmetik and angrenzende Gebiete [Encyclopedia of auxiliary substances for pharmacy; cosmetics and related fields], 4th edition, Aulendorf: ECV-Editio-Kantor-Verlag, 1996.
The following examples serve to explain the invention without limiting it.
The compounds were either characterized via proton-NMR in d6-dimethylsulfoxide or d-chloroform, if not stated otherwise, on a 400 MHz or 500 MHz NMR instrument (Bruker AVANCE), or by mass spectrometry, generally recorded via HPLC-MS in a fast gradient on C18-material (electrospray-ionisation (ESI) mode), or melting point.
The magnetic nuclear resonance spectral properties (NMR) refer to the chemical shifts (δ) expressed in parts per million (ppm). The relative area of the shifts in the 1H NMR spectrum corresponds to the number of hydrogen atoms for a particular functional type in the molecule. The nature of the shift, as regards multiplicity, is indicated as singlet (s), broad singlet (s. br.), doublet (d), broad doublet (d br.), triplet (t), broad triplet (t br.), quartet (q), quintet (quint.) and multiplet (m).
PREPARATION EXAMPLES
I. Preparation of Intermediates
a. Synthesis of Sulfonyl Chlorides
a.1 4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride
a.1.1 Toluene-4-sulfonic acid (S)-2-phenyl-propyl ester
To a solution of 20 g of (S)-(−)-2-phenyl-1-propanol in 240 ml of dichloromethane was added in portions 28 g of p-toluenesulfonyl chloride (146.8 mmol). After stirring for 18 h at room temperature, the organic phase was washed with 100 ml of water, dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to yield 43 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.65 (d, 2H), 7.15-7.3 (m, 5H), 7.1 (d, 2H), 4.0-4.1 (m, 2H), 3.1 (m, 1H), 2.4 (s, 3H), 1.3 (d, 3H).
a.1.2 ((S)-2-Fluoro-1-methyl-ethyl)-benzene
9.62 g of toluene-4-sulfonic acid (S)-2-phenyl-propyl ester (33.13 mmol) were dissolved in 80 ml of polyethylenglycol 400. 9.62 g of potassium fluoride (165.6 mmol) were added and the reaction mixture was stirred at 50° C. for 3 days and another 2 days at 55-70° C. The reaction was treated with 150 ml of saturated aqueous sodium chloride solution, extracted three times with diethyl ether, and the combined organic layers were dried over magnesium sulfate, filtered, and the solvent was evaporated under reduced pressure. The crude product was purified via silica gel chromatography using cyclohexyane/ethyl acetate 15% as eluent. 2.85 g of the desired product were isolated, containing  ̃25% of the elimination side product.
1H-NMR (CDCl3, 400 MHz): δ [ppm]7.2-7.4 (m, 5H), 4.3-4.6 (several m, 2H), 3.15 (m, 1H).1.3 (m, 3H).
a.1.3 4-((S)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride
3.5 g of ((S)-2-fluoro-1-methyl-ethyl)-benzene (25.32 mmol) were dissolved in 80 ml of dichloromethane. At 0-5° C., 11.81 g of chlorosulfonic acid (101.31 mmol), dissolved in 20 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 30 min at room temperature and 2 h at 30° C. The solvent was evaporated. 150 ml of diethyl ether were added to the residue, washed once with 150 ml of water, and the organic layer was dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure. The crude product was purified via silica gel chromatography with n-heptane-dichloromethane (6:4) as eluent to give 1.5 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.5 (d, 2H), 4.5 (dd, 2H), 3.25 (m, 1H), 1.4 (d, 3H).
a.2 4-((R)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride
a.2.1 Toluene-4-sulfonic acid (R)-2-phenyl-propyl ester
Following the procedure analogous to that used for the synthesis of toluene 4-sulfonic acid (S)-2-phenyl-propyl ester, but using (R)-2-phenyl-1-propanol, the title compound was prepared
a.2.2 ((R)-2-Fluoro-1-methyl-ethyl)-benzene
The title compound was prepared as described above for the synthesis of ((S)-2-fluoro-1-methyl-ethyl)-benzene, but using toluene-4-sulfonic acid (R)-2-phenyl-propyl ester instead of toluene-4-sulfonic acid (S)-2-phenyl-propyl ester.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.2-7.4 (m, 5H), 4.3-4.6 (several m, 2H), 3.15 (m, 1H).1.3 (m, 3H).
a.2.3 4-((R)-2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride
1.3 g of ((R)-2-fluoro-1-methyl-ethyl)-benzene (9.4 mmol) were dissolved in 50 ml of dichloromethane. At 0-5° C., 1.1 g of chlorosulfonic acid (9.4 mmol), dissolved in 10 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 20 min at 0-5° C. and then added to a solution of 2.15 g of phosphorous pentachloride dissolved in 40 ml of dichloromethane. The reaction mixture was stirred for 30 min at 0-5° C. and 1 h at room temperature. The solvent was evaporated, 100 ml of diethyl ether were added, the mixture was washed once with 150 ml of water, and the organic layer dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure. The crude product was purified via silica gel chromatography with n-heptane-dichloromethane (1:1) as eluent to give 0.261 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.5 (d, 2H), 4.5 (dd, 2H), 3.25 (m, 1H), 1.4 (d, 3H).
a.3 4-(2-Fluoro-1-methyl-ethyl)-benzenesulfonyl chloride
Following the procedures analogous to that used for the preparation of 4-((S)-2-fluoro-1-methyl-ethyl)-benzenesulfonyl chloride, but starting with 2-phenyl-1-propanol in step a.3.1, the title compound was prepared.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.5 (d, 2H), 4.5 (dd, 2H), 3.25 (m, 1H), 1.4 (d, 3H).
a.4 4-(2-Fluoro-1-fluoromethyl-ethyl)-benzenesulfonyl chloride
a.4.1 (2-Fluoro-1-fluoromethyl-ethyl)-benzene
4 g of 3-phenylglutaric acid (19.21 mmol) were suspended in 350 ml of dichloromethane. At room temperature, 6.5 g of xenon difluoride (38.42 mmol) were added and the reaction mixture was stirred at room temperature for 18 h. The organic phase was washed once with 975 ml of 6% aqueous sodium hydrogencarbonate, dried over magnesium sulfate, filtered, and the solvent evaporated. The remaining residue was distilled at a bath temperature of 123° C. at 21 mm to yield 0.78 g of the title compound that contained  ̃50% of 4-(2-Fluoro-1-methyl-ethyl)-benzene.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.2-7.4 (m, 5H), 4.6-4.8 (dd, 4H), 3.3 (m, 1H).
a.4.2 4-(2-Fluoro-1-fluoromethyl-ethyl)benzenesulfonyl chloride
Following the procedures analogous to that used for the preparation of 4-((S)-2-fluoro-1-methyl-ethyl)-benzenesulfonyl chloride, but using 5 equivalents. of chlorosulfonic acid, 0.12 g of the title compound were obtained.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.05 (d, 2H), 7.55 (d, 2H), 4.75 (dd, 4H), 3.4 (m, 1H).
a.5 4-(3,3,3-Trifluoropropyl)-benzenesulfonyl chloride
2.9 g were obtained from commercially available (3,3,3-trifluoropropyl)-benzene following the procedure used for the synthesis of 4-((S)-2-fluoro-1-methyl-ethyl)-benzenesulfonyl chloride described above.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.45 (d, 2H), 3.0 (t, 2H), 2.45 (m, 2H).
a.6 4-(2,2,2-Trifluoroethyl)-benzenesulfonyl chloride
The product was obtained from commercially available (2,2,2-trifluoroethyl)-benzene following the procedure as described in J. Org. Chem., 1960, 25, 1824-26.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.05 (d, 2H), 7.55 (d, 2H), 3.5 (q, 2H).
a.7 4-(3-Fluoropropyl)-benzenesulfonyl chloride
a.7.1 (3-Fluoropropyl)-benzene
15.6 g of diethylaminosulfurtrifluoride (DAST, 96.91 mmol) were dissolved in 18 ml of dichloromethane. At 0-5° C., 12 g of 3-phenyl-1-propanol (88.1 mmol) dissolved in 30 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 18 h, and, after addition of 30 ml of dichloromethane, poured onto 100 ml of ice water. The organic layer was separated, dried over magnesium sulfate, filtered, and the solvent evaporated. The crude product was purified by distillation at a bath temperature of 106° C. at 20 mm to yield 7.4 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.1-7.3 (m, 5H), 4.4 (dt, 2H), 2.7 (m, 2H).2.0 (m, 2H).
a.7.2 4-(3-Fluoropropyl)-benzenesulfonyl chloride
4.1 g of (3-fluoro-propyl)-benzene (29.67 mmol) were dissolved in 40 ml of dichloromethane. At 0-5° C., 6.91 g of chlorosulfonic acid (59.34 mmol), dissolved in 10 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 45 min at 0-5° C. and then added to a solution of 6.8 g of phosphorous pentachloride (32.63 mmol) dissolved in 50 ml of dichloromethane. The reaction mixture was stirred for 1 h at 5-10° C. The solvent was evaporated, 150 ml of diethyl ether added, washed once with 150 ml of ice water, and the organic layer dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure. The crude product was purified via silica gel chromatography with n-heptane-dichloromethane (11:9) as eluent to give 5.5 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.95 (d, 2H), 7.45 (d, 2H), 4.5 (dt, 2H), 2.9 (t, 2H), 2.05 (m, 2H).
a.8 4-(2,2-Difluoro-cyclopropyl)-benzenesulfonyl chloride
2.07 g of were obtained from commercially available (2,2-difluorocyclopropyl)-benzene following the procedure used for the synthesis of (3-fluoropropyl)-benzenesulfonyl chloride with the exception that only 1.1 equivalents of phosphorous pentachloride were used.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.45 (d, 2H), 2.85 (m, 1H), 2.0 (m, 1H), 1.75 (m, 1H).
a.9 3-Bromo-4-trifluoromethoxy-benzenesulfonyl chloride
2.0 g of 1-bromo-2-(trifluoro-methoxy)benzene (8.3 mmol) were dissolved in 30 ml of dichloromethane. At 0-5° C., 1.06 g of chlorosulfonic acid (9.13 mmol), dissolved in 3 ml of dichloromethane, were added dropwise. The reaction mixture was stirred for 30 min at room temperature. Additional 5.5 equivalents of chlorosulfonic in dichloromethane were added to drive the reaction to completion. Standard work-up was followed and silica gel chromatography with n-heptane-dichloromethane (6:4) as eluent gave 2.19 g of the title compound.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.3 (d, 1H), 8.05 (dd, 1H), 7.5 (dd, 1H).
a.10 4-(2-Fluoroethyl)-benzenesulfonyl chloride
a.10.1 (2-Fluoroethyl)-benzene
6.8 g of the title compound were obtained from commercially available 2-phenylethanol following the procedure used for the synthesis of (3-fluoropropyl)-benzene.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.1-7.3 (m, 5H), 4.6 (m, 1H), 4.45 (m, 1H), 2.95 (m, 1H), 2.9 (m, 1H).
a.10.2 4-(2-Fluoroethyl)-benzenesulfonyl chloride
3.55 g were obtained following the procedure used for the synthesis of 4-(R)-2-fluoro-1-methyl-ethylybenzenesulfonyl chloride.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.5 (d, 2H), 4.7 (dt, 2H), 3.05-3.2 (dt, 2H).
a.11 5-Propylthiophene-2-sulfonyl chloride
Following the procedures analogous to that used for the preparation of (3-fluoro-propyl)-benzenesulfonyl chloride, but using only 1 equivalent of phosphorous pentachloride, the title compound was prepared.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.7 (d, 1H), 6.85 (d, 1H), 2.9 (t, 2H), 1.75 (m, 2H), 1.0 (t, 3H).
a.12 4-(1-Methyl-1H-pyrazol-4-yl)-benzenesulfonyl chloride
a.12.1 1-Methyl-4-phenyl-1H-pyrazole
1 g of 2-phenylmalonaldehyde (6.75 mmol) were dissolved in 25 ml of ethanol. 0.36 ml of N-methyl-hydrazine (6.75 mmol) were added, the reaction mixture was stirred under reflux for 4 h, the solvent evaporated under reduced pressure to yield 1.09 g of the product.
ESI-MS: 159.1 [M+H]+
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.75 (s, 1H), 7.6 (s, 1H), 7.45 (d, 2H), 7.35 (t, 2H), 7.2 (t, 1H), 3.9 (s, 3H)
a.12.2 4-(1-Methyl-1H-pyrazol-4-yl)-benzenesulfonyl chloride
0.5 g of 1-methyl-4-phenyl-1H-pyrazole (3.16 mmol) were dissolved in 20 ml of dichloromethane. At 0° C., 0.232 ml of chlorosulfonic acid were added and the reaction mixture was stirred for 1 h under ice cooling. Additional 0.7 ml of chlorosulfonic acid were added, the mixture was stirred at 0° C. for 30 minutes and then 90 minutes at 50° C. The two phases were separated and the lower layer put on ice, extracted twice with diethyl ether, dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to yield 0.496 g of the product.
1H-NMR (CDCl3, 400 MHz): δ [ppm] 8.0 (d, 2H), 7.85 (s, 1H), 7.75 (s, 1H), 7.65 (d, 2H), 4.0 (s, 3H).
a.13 4-(1,1,1-Trifluoropropan-2-yl)benzenesulfonyl chloride and 2-(1,1,1-trifluoropropan-2-yl)benzenesulfonyl chloride
Prepared on a 14 g scale following the procedure outlined in Scheme 7. 2-(1,1,1-Trifluoropropan-2-yl)benzenesulfonyl chloride is a by-product of the reaction.
4-(1,1,1-Trifluoropropan-2-yl)benzenesulfonyl chloride:
MS (ESI) m/z: 273.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.62 (d, 2H), 7.33 (d, 2H), 3.81 (m, 1H), 1.42 (d, 3H).
2-(1,1,1-Trifluoropropan-2-yl)benzenesulfonyl chloride:
MS (ESI) m/z: 273.1 [M+H]+
a.14 4-(1,1-Difluoropropan-2-yl)benzenesulfonyl chloride and 2-(1,1-Difluoropropan-2-yl)benzene-1-sulfonyl chloride
Prepared on an 11 g scale following the procedure outlined in Scheme 6. 2-(1,1-Difluoropropan-2-yl)benzene-1-sulfonyl chloride is a by-product of the reaction.
4-(1,1-Difluoropropan-2-yl)benzenesulfonyl chloride:
MS (ESI) m/z: 255.0 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 8.03 (d, 2H), 7.55 (d, 2H), 5.88 (dt, 1H), 3.34 (m, 1H), 1.47 (d, 3H).
13C-NMR (DMSO-d6): δ [ppm] 146.43, 143.54, 129.77, 127.28, 117.06 (t), 43.76, 13.78.
2-(1,1-difluoropropan-2-yl)benzene-1-sulfonyl chloride:
Isolated by chromatography on 110 mg scale.
MS (ESI) m/z: 255.0 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 8.15 (d, 1H), 7.77 (t, 1H), 7.70 (d, 1H), 7.54 (t, 1H), 5.99 (dt, 1H), 4.43 (m, 1H), 1.51 (d, 3H).
13C-NMR (DMSO-d6): δ [ppm] 143.45, 138.63, 135.53, 130.93, 129.04, 128.17, 116.61 (t), 38.38, 13.68.
II. Preparation of Compounds I
Example 1
4-Isopropyl-N-(2-propylaminomethyl-1H-indol-5-yl)-benzenesulfonamide
1.1 5-Nitro-1H-indole-2-carboxylic acid
To a solution of ethyl-5-nitro-1H-indole-2-carboxylate (22.7 g, 96.83 mg) in ethanol (EtOH) (150 ml) sodium hydroxide (11.62 g, 290.5 mmol) was added. The mixture was stirred at room temperature for 16 h. During this time a brown solid formed. After evaporation of the solvent under reduced pressure the residue was suspended in water and HCl was added. The color of the precipitate changed from brown to yellow. After filtration the residue was washed with water and dried in a vacuum oven at 50° C. to give the product as a brown powder (19.53 g, 98%).
1.2 5-Nitro-1H-indole-2-carboxylic acid propylamide
To a solution of 5-nitro-1H-indole-2-carboxylic acid (6.95 g, 33.7 mmol) in N,N-dimethylformamide (DMF)/pyridine (1/1, 150 ml) N,N′-carbonyl-diimidazole (5.47 g, 33.71 mmol) was added. The mixture was stirred at 80° C. for 1 h. At 0° C. propylamine (9.96 g, 168.56 mmol) was added. The mixture was stirred at 0° C. for 1 h and then at room temperature for 16 h. The solution was diluted with water (2 I). After addition of sodium chloride the product precipitated. After filtration the residue was washed with water and pentane, and dried in a vacuum oven at 50° C. to give the product as a yellow powder.
MS (ESI) m/z: 248.05 [M+H]+
1.3 5-Amino-1H-indole-2-carboxylic acid propylamide
To a solution of 5-nitro-1H-indole-2-carboxylic acid propylamide (2.94 g, 11.9 mmol) in EtOH (150 ml) a suspension of palladium on charcoal (10%, 1 g) in EtOH was added. The mixture was hydrogenated at atmospheric pressure. After filtration and removal of the solvents in vacuo the product was obtained as a yellow powder (2.46 mg, 95%).
MS (ESI) m/z: 218.15 [M+H]+
1.4 5-(4-Isopropyl-benzenesulfonylamino)-1H-indole-2-carboxylic acid propylamide
To a solution of 5-amino-1H-indole-2-carboxylic acid propylamide (500 mg, 2.3 mmol) in pyridine (20 ml) 4-isopropyl-benzenesulfonyl chloride (500 mg, 2.3 mmol) was added. The mixture was stirred at room temperature for 16 h. After evaporation of the solvent the residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The organic layer was separated, washed with saturated aqueous NaHCO3 and dried over MgSO4. The filtered solution was evaporated to give the product as a yellow powder (910 mg, 98.8%).
MS (ESI) m/z: 400.01 [M+H]+
1.5 4-Isopropyl-N-(2-propylaminomethyl-1H-indol-5-yl)-benzenesulfonamide
To a suspension of lithium aluminiumhydride (590 mg, 15.54 mmol) in tetrahydrofuran (THF) (40 ml, dried over Al2O3) at −5 to 0° C. a solution of 5-(4-isopropyl-benzenesulfonylamino)-1H-indole-2-carboxylic acid propylamide (1.03 g, 2.59 mmol) in THF (10 ml) was added. After complete addition the mixture was allowed to warm to room temperature and was heated to reflux for 3 h. At 0° C. THF and then water were added. The mixture was dried with Na2SO4. The filtered solution was evaporated and the residue was purified by column chromatography (toluene:THF:methanol, 4:1:1+2.5% triethylamine) to give the product as a yellow powder (240 mg, 24%).
MS (ESI) m/z: 386.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 10.95 (bs, 1H), 7.60 (d, 2H), 7.35 (d, 2H), 7.07-7.20 (m, 2H), 6.75-6.79 (m, 1H), 6.18 (s, 1H), 3.79 (s, 2H), 2.85-2.96 (m, 1H), 2.40-2.55 (m, 2H), 1.39-1.49 (m, 2H), 1.10-1.20 (m, 6H), 0.85 (t, 3H).
Example 2
4-Isopropyl-N-(2-propylaminomethyl-2,3-dihydro-1H-indol-5-yl)-benzenesulfonamide×HCl
To 4-isopropyl-N-(2-propylaminomethyl-1H-indol-5-yl)-benzenesulfonamide (110 mg, 0.27 mmol) trifluoroacetic acid (TFA) (5 ml) was added at 0° C. followed by adding sodium borohydride pellets (50 mg, 1.36 mmol). The temperature during addition was kept below 10° C. After complete addition the mixture was stirred for 2 h at 0° C. The mixture carefully was added to an ice cold saturated aqueous solution of NaHCO3. The aqueous layer was extracted three times with dichloromethane. The combined organic layers were dried over MgSO4, filtered and the solvent evaporated under reduced pressure. To a solution of the residue in ethyl acetate/diethyl ether a solution of HCl in diethyl ether (1M) was added. The resulting precipitate was collected and dried in vacuo at 30° C. to give the product as purple crystals (60 mg, 51%).
MS (ESI) m/z: 388.15 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 9.61 (bs, 1H), 8.85 (bs, 2H), 7.60 (d, 2H), 7.48 (d, 2H), 6.80 (s, 1H), 6.65 (d, 1H), 6.40 (d, 1H), 4.03-4.15 (m, 1H), 2.80-3.10 (m, 6H), 2.65-2.75 (m, 1H), 1.60-1.70 (m, 2H), 1.15-1.20 (m, 6H), 0.90 (t, 3H).
Example 3
N-(2-Propylaminomethyl-1H-indol-5-yl)-4-trifluoromethoxy-benzenesulfonamide×1⁄2 fumaric acid
3.1 5-(4-Trifluoromethoxy-benzenesulfonylamino)-1H-indole-2-carboxylic acid propylamide
To a solution of 5-amino-1H-indole-2-carboxylic acid propylamide (500 mg, 2.3 mmol) in pyridine (20 ml) 4-trifluoromethoxy-benzenesulfonyl chloride (600 mg, 2.3 mmol) was added. The mixture was stirred at room temperature for 16 h. After evaporation of the solvent the residue was partitioned between ethyl acetate and saturated aqueous. The organic layer was separated, washed with saturated aqueous NaHCO3 and dried over MgSO4. The filtered solution was evaporated to give the product as a yellow powder (1.01 g, 99%).
MS (ESI) m/z: 442.0 [M+H]+
3.2 N-(2-Propylaminomethyl-indol-5-yl)-4-trifluoromethoxy-benzenesulfonamide×1⁄2 fumaric acid
To a suspension of lithium aluminiumhydride (500 mg, 13.18 mmol) in THF (40 ml, dried over Al2O3) at −5-0° C. a solution of 5-(4-trifluoromethoxy-benzenesulfonylamino)-1H-indole-2-carboxylic acid propylamide (970 mg, 2.20 mmol) in THF (10 ml) was added. After complete addition the mixture was allowed to warm to room temperature and was heated to reflux for 3 h. At 0° C. THF and then water were added. The mixture was dried with Na2SO4. The filtered solution was evaporated in vacuo and the residue was purified by column chromatography (toluene:THF:methanol, 4:1:1, +2.5% triethylamine). To a solution of the obtained oil in isopropanol fumaric acid (254 mg, 2.19 mmol) was added. The precipitate was recrystallized from ethanol to give the product as a yellow powder (220 mg, 18%).
MS (ESI) m/z: 428.0 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.78 (d, 2H), 7.47 (d, 2H), 7.10-7.20 (m, 2H), 6.70-6.80 (m, 1H), 6.55 (s, 1H), 6.23 (s, 1H), 3.89 (s, 2H), 2.53-2.60 (m, 2H), 1.45-1.55 (m, 2H), 0.86 (t, 3H).
Example 4
N-(2-Propylaminomethyl-2,3-dihydro-1H-indol-5-yl)-4-trifluoromethoxy-benzenesulfonamide×HCl
A solution of 5-(4-trifluoromethoxy-benzenesulfonylamino)-1H-indole-2-carboxylic acid propylamide (960 mg, 2.18 mmol) in THF (25 ml) was heated to reflux and a solution of borane-dimethylsulfide complex (2M in THF, 19.6 mmol) was added. The mixture was heated to reflux for 10 h. At room temperature the mixture was adjusted to pH=1 by adding a solution of HCl in ethanol and stirred for 15 min. After evaporation of the solvents the residue was partitioned between ethyl acetate and HCl (2M). To the separated aqueous layer aqueous ammonia was added (pH=9). After extraction with dichloromethane the organic layer was dried over MgSO4 and evaporated. To a solution of the residue in diethyl ether HCl in diethyl ether (1M) was added. The resulting precipitate was collected, washed with diethyl ether and dried in vacuo at 30° C. to give the product as a yellow powder (160 mg, 16%).
MS (ESI) m/z: 430.15 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 9.90 (s, 1H), 9.05 (bs, 2H), 7.62 (d, 2H), 7.55 (d, 2H), 6.81 (s, 1H), 6.68 (d, 1H), 6.49 (d, 1H), 4.10-4.20 (m, 1H), 2.70-3.15 (m, 6H), 1.60-1.70 (m, 2H), 0.91 (t, 3H).
Example 5
4-Isopropyl-N-(5-propylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide×HCl
5.1 5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamine×2 HCl
5-Aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamine×2 HCl was synthesized according to a synthetic protocol described in EP325963 starting from commercially available N-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetamide.
5.2 N-(6-Amino-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-propionamide
A solution of 5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-ylamine×2 HCl (500 mg, 2.01 mmol) in water (90 ml) was adjusted to pH=11.25 by adding aqueous NaOH (0.5M). Then propionic acid anhydride (290 mg, 2.21 mmol) was added slowly while maintaining the pH in a range from 11.2 to 11.3 by simultaneously adding aqueous NaOH (0.5M). After complete addition the mixture was adjusted to pH=2.5 with aqueous HCl (1N) and evaporated under reduced pressure. The residue was dissolved in water, and washed twice with ethyl acetate. After addition of aqueous ammonia the aqueous layer was extracted three times with dichloromethane. The combined dichloromethane layers were dried over MgSO4, and evaporated under reduced pressure to give the product as a yellow resin (320 mg, 68%).
MS (ESI) m/z: 233.15 [M+H]+
5.3 N-[6-(4-Isopropyl-benzenesulfonylamino)-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl]-propionamide
To a solution of N-(6-amino-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-propionamide (290 mg, 1.26 mmol) in pyridine (10 ml) at 0° C. 4-isopropyl-benzenesulfonyl chloride (280 mg, 1.26 mmol) was added. The mixture was stirred at 0° C. for 1 h and 16 h at room temperature. After evaporation under reduced pressure the obtained residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The organic layer was washed twice with saturated aqueous NaHCO3, dried over MgSO4, filtered and the solvent evaporated under reduced pressure to give the product as a brown resin (530 mg, 100%).
MS (ESI) m/z: 415.15 [M+H]+
5.4 4-Isopropyl-N-(5-propylaminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide×HCl
To a solution of N-[6-(4-isopropyl-benzenesulfonylamino)-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl]-propionamide (510 mg, 1.23 mmol) in THF (20 ml) borane-dimethylsulfide complex (2M in THF, 3.06 mmol) was added. The mixture was heated to reflux for 2 h. At room temperature HCl in ethanol (2M) was added and the mixture was stirred for 30 min. After evaporation under reduced pressure the residue was triturated with diethyl ether. After filtration the residue was washed with diethyl ether and dried in vacuo to give the product as yellow crystals (490 mg, 92%).
MS (ESI) m/z: 401.15 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 10.21 (s, 1H), 8.80 (bs, 1H), 8.60 (bs, 1H), 7.71 (d, 2H), 7.45 (d, 2H), 7.15 (d, 1H), 6.93 (d, 1H), 6.82 (s, 1H), 2.80-3.20 (m, 6H), 2.52-2.61 (m, 2H), 1.55-1.90 (m, 6H), 1.15-1.29 (m, 6H), 0.90 (t, 3H).
Example 6
4-Isopropyl-N-(2-propylaminomethyl-1H-benzoimidazol-5-yl)-benzenesulfonamide
6.1 N-(4-Amino-3-nitro-phenyl)-4-isopropyl-benzenesulfonamide
To a mixture of 2-nitro-benzene-1,4-diamine (10 g, 65.30 mmol) and N,N-dimethylaniline (8.7 g, 71.83 mmol) in acetonitrile (310 ml) at 0° C. 4-isopropyl-benzenesulfonylchloride (13.85 g, 63.34 mmol) was added over a period of 1 h. The mixture was stirred at 0° C. for 1 h and for 16 h at room temperature. After concentrating the mixture in vacuo the obtained oil was triturated with water. The precipitate was collected, washed with ethanol and dried in vacuo to give the product as a yellow powder (11.76 g, 54%).
6.2 N-(3,4-Diamino-phenyl)-4-isopropyl-benzenesulfonamide×HCl
A mixture of N-(4-amino-3-nitro-phenyl)-4-isopropyl-benzenesulfonamide (5 g, 14.91 mmol) and palladium on charcoal (10%, 500 mg) in ethanol (100 ml) was hydrogenated at atmospheric pressure. After filtration the mixture was concentrated in vacuo. The brown oil was dissolved in dichloromethane and a solution of HCl in isopropanol was added. The precipitate was collected and dried in vacuo to give the product as a brown powder (4.9 g, 87%).
6.3 N-[5-(4-Isopropyl-benzenesulfonylamino)-1H-benzoimidazol-2-ylmethyl]-propionamide
To a solution of N-(3,4-diamino-phenyl)-4-isopropyl-benzenesulfonamide×HCl (500 mg, 1.32 mmol) in DMF (20 ml) at 0° C. was added propionylamino-acetic acid (170 mg, 1.32 mmol) and 1-hydroxy-7-azabenzotriazole (HOAt) (220 mg, 1.59 mmol). After stirring the mixture at 0° C. for 15 min EDC (N-ethyl-N′-(3-dimethylaminopropyl)-carbodiimide) (300 mg, 1.45 mmol) was added. DIPEA (diisopropylethylamine) (0.92 ml, 5.29 mmol) was added after stirring another 15 min at 0° C. The mixture was stirred at room temperature for 16 h, and then concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous NaHCO3 and the organic layer was dried over MgSO4, filtered, and the solvent evaporated under reduced pressure. A solution of the obtained oil in acetic acid was heated to 70° C. for 6 h. After evaporation of the solvent in vacuo the residue was purified by column chromatography to give the product as a yellow oil (320 mg, 61%).
6.4 4-Isopropyl-N-(2-propylaminomethyl-1H-benzoimidazol-5-yl)-benzenesulfonamide
To a suspension of lithium-aluminiumhydride (180 mg, 4.79 mmol) in THF (5 ml, dried Al2O3) at −5-0° C. a solution of N-[5-(4-isopropyl-benzenesulfonylamino)-1H-benzoimidazol-2-ylmethyl]-propionamide (320 mg, 0.80 mmol) in THF (5 ml) was added. After complete addition the mixture was allowed to warm to room temperature and was heated to reflux for 2 h. At 0° C. THF and then water were added. The mixture was dried with Na2SO4. The filtered solution was evaporated in vacuo and the residue was purified by preparative HPLC (water/5% acetonitrile/0.1% acetic acid) to give the product as a yellow oil (10 mg, 3%).
MS (ESI) m/z: 387.25 [M+H]+
1H-NMR (CDCl3): δ [ppm] 7.62 (d, 2H), 7.55-7.65 (m, 2H), 7.75 (s, 1H), 7.46 (d, 2H), 7.61 (d, 1H), 4.08 (s, 2H), 2.85-2.91 (m, 1H), 2.62-2.70 (m, 2H), 1.48-1.56 (m, 2H), 1.18-1.22 (m, 6H), 0.91 (t, 3H).
Example 7
4-Isopropyl-N-(2-propylaminomethyl-indan-5-yl)-benzenesulfonamide
7.1 Methanesulfonic acid indan-2-yl ester
2-Indanol (20.00 g, 149.5 mmol) and diisopropylethylamine (21.2 g, 164 mmol) was stirred in dichloromethane (300 mL) at 0° C. Methanesulfonyl chloride (18.78 g, 164 mmol) and dimethylaminopyridine (1.80 g) were added simultaneously and stirring continued at room temperature for 18 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated. This was washed with NaHCO3 (sat) and with citric acid solution (5%) and dried over MgSO4. The filtered solution was concentrated and the resultant solid recrystallized from isopropanol-EtOH (3:1) to give off-white crystals (24.6 g, 78%).
MS (ESI) m/z: 230.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.28 (m, 2H), 7.18 (m, 2H), 5.46 (m, 1H), 3.34 (m, 2H), 3.15 (m, 2H).
13C-NMR (DMSO-d6): δ [ppm] 139.5 (s), 126.8 (d), 124.5 (d), 82.7 (d), 37.6 (t).
7.2 Indan-2-carbonitrile
A mixture of methanesulfonic acid indan-2-yl ester (18.65 g, 87.9 mmol) and tetraethylammonium cyanide (15.10 g) in acetonitrile (180 mL) was heated to 55° C. for 5 hours, cooled and concentrated. The residue was partitioned between ethyl acetate and water, and the organic phase separated. This was dried over MgSO4 and the filtered solution was concentrated and then separated by column chromatography (dichloromethane:ethyl acetate, 6:1-1:1) to give the product as a red solid (6.51 g, 52%).
MS (ESI) m/z: 144.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.28 (m, 2H), 7.18 (m, 2H), 3.52 (m, 1H), 3.31 (m, 2H), 3.17 (m, 2H).
7.3 Indan-2-yl-methylamine
The indan-2-carbonitrile (1.60 g, 11.2 mmol) was dissolved in diethyl ether (50 mL) and LiAlH4 (0.43 g, 11.3 mmol) added in portions at 0° C. and the solution stirred for a further 3 h at 5° C. The reaction was quenched by the sequential addition of water, NaOH solution (10%) and water. The organic phase was separated, dried (MgSO4), filtered and concentrated to give the title compound as a light brown oil (1.30 g, 79%).
MS (ESI) m/z: 148.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.18 (m, 2H), 7.06 (m, 2H), 3.35 (m, 1H), 2.90 (m, 2H), 2.52 (m, 3H), 2.35 (m, 1H), 1.40 (br s, 1H).
7.4 N-Indan-2-ylmethyl-propionamide
A solution of indan-2-yl-methylamine (5.55 g, 37.7 mmol) and triethylamine (5.67 g, 56.0 mmol) in 100 mL THF was stirred at 5° C. and propionic anhydride (5.15 g, 39.6 mmol) added dropwise. After the mixture was stirred for 18 h at room temperature, the solvent was removed and ethyl acetate/water were added. The organic layer was washed with water and dried over MgSO4. The filtrate was concentrated to give a brown oil (8.79 g, 97%).
MS (ESI) m/z: 204.1 [M+H]+
7.5 N-(5-Nitro-indan-2-ylmethyl)-propionamide
N-Indan-2-ylmethyl-propionamide (4.00 g, 19.7 mmol) was dissolved in nitromethane (60 mL) and added to a mixture of concentrated H2SO4 (19 mL), concentrated nitric acid (1.4 mL) and water (3.2 mL) cooled to 5° C. After stirring for 45 min, the reaction solution was poured into water, extracted with ethyl acetate and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give a brown oil (4.67 g, 96%).
MS (ESI) m/z: 249.1 [M+H]+
7.6 N-(5-Amino-indan-2-ylmethyl)-propionamide
The mixture of nitro compounds (4.67 g, 18.8 mmol) was dissolved in methanol (MeOH)(250 mL) and tin chloride (12.7 g, 56.3 mmol) added. The solution was heated to reflux for 3 h and then a second portion of tin chloride was added and reflux continued for a further 3 h. The solution was concentrated and the residue was partitioned between ethyl acetate and NaOH (2M), and the organic phase separated and dried over MgSO4. The filtered solution was concentrated and the residue separated by preparative HPLC (20-90% MeOH) to give the 2 amino isomers. The product was obtained as a yellow oil (0.97 g, 24%).
MS (ESI) m/z: 219.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.75 (m, 1H), 6.76 (d, 2H), 6.37 (s, 1H), 6.31 (d, 1H), 3.08 (m, 2H), 2.42 (m, 2H), 2.07 (m, 2H), 0.97 (t, 3H).
7.7 N-[5-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide
N-(5-Amino-indan-2-ylmethyl)-propionamide (0.93 g, 4.26 mmol) was dissolved in pyridine-dichloromethane (1:2, 60 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.98 g, 4.48 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (1.69 g, 99%).
MS (ESI) m/z: 401.1 [M+H]+
7.8 4-Isopropyl-N-(2-propylaminomethyl-indan-5-yl)-benzenesulfonamide
N-[5-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]propionamide (0.50 g, 1.25 mmol) was dissolved in 10 mL of THF and 4.2 mL (43.9 mmol) of a borane-THF complex was introduced dropwise. The resulting mixture was stirred at reflux for 1 h. The solution was cooled, 5 mL of 2 N HCl was added slowly, and the mixture was stirred at reflux for 2 h. The cooled solution was quenched with water, then NaOH (2N) and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered, and the filtrate was evaporated in vacuo to give product as a white solid which was further purified by column chromatography using (dichloromethane-MeOH, 7-12%) to give an oil. The oil was dissolved in ethyl acetate and HCl (4M, dioxane) was added to give the product as a white solid (40 mg, 7%).
MS (ESI) m/z: 387.2 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.69 (d, 2H), 7.40 (d, 2H), 7.03 (d, 1H), 6.94 (s, 1H), 6.84 (d, 1H), 2.90 (m, 3H), 2.81 (d, 2H), 2.70-2.55 (m, 5H), 1.55 (m, 2H), 0.85 (t, 3H).
13C-NMR (DMSO-d6): δ [ppm] 153.4 (s), 143.2 (s), 137.9 (s), 137.3 (s), 136.1 (s), 127.1 (d), 126.7 (d), 124.7 (d) 118.4 (d), 116.5 (d), 51.9 (t), 49.6 (t), 37.4 (d), 36.0 (t), 33.2 (d), 23.3 (q), 20.0 (t), 11.2 (q).
Example 8
4-Isopropyl-N-(2-propylaminomethyl-indan-4-yl)-benzenesulfonamide
8.1 N-(4-Nitro-indan-2-ylmethyl)-propionamide
The title compound was prepared in an analogous manner as described above.
MS (ESI) m/z: 249.1 [M+H]+
8.2 N-(4-Amino-indan-2-ylmethyl)-propionamide
The title compound was prepared in an analogous manner as described above. (0.55 g, 14%).
MS (ESI) m/z: 219.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.82 (s, 1H), 6.85 (t, 1H), 6.37 (m, 2H), 4.72 (br s, 2H), 3.08 (m, 2H), 2.85 (m, 1H), 2.75 (m, 1H), 2.52 (m, 2H), 2.32 (m, 1H), 2.08 (m, 2H), 1.00 (t, 3H).
8.3 N-[4-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide
N-(4-Amino-indan-2-ylmethyl)-propionamide (0.51 g, 2.34 mmol) was dissolved in pyridine-dichloromethane (1:2, 30 mL) and cooled to 5° C. 4-Isopropylbenzenesulfonyl chloride (0.54 g, 2.47 mmol) was added and the solution stirred at 5° C. for 3 h. Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated to give the product as a brown oil (0.95 g, 100%).
MS (ESI) m/z: 401.1 [M+H]+
8.4 4-Isopropyl-N-(2-propylaminomethyl-indan-4-yl)-benzenesulfonamide
N-[4-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]propionamide (0.30 g, 0.75 mmol) was dissolved in 10 mL of THF and 2.5 mL (26.1 mmol) of a borane-THF complex was introduced dropwise. The resulting mixture was stirred at reflux for 1 h. The solution was cooled, 3 mL of 2 N HCl was added slowly, and the mixture was stirred at reflux for 2 h. The cooled solution was quenched with water, then NaOH (2N) and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered, and the filtrate was evaporated in vacuo to give product as a white solid which was further purified by column chromatography using (dichloromethane-MeOH, 7-12%) to give an oil. The oil was dissolved in ethyl acetate and HCl (4M, dioxane) was added to give the product as a white solid (140 mg, 43%).
MS (ESI) m/z: 387.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.68 (d, 2H), 7.26 (d, 2H), 6.93 (d, 1H), 6.88 (s, 1H), 6.73 (d, 1H), 2.98 (m, 3H), 2.74 (m, 4H), 2.60 (m, 2H), 1.22 (d, 6H), 0.89 (t, 3H).
Example 9
4-Isopropyl-N-(2-allylaminomethyl-indan-4-yl)-benzenesulfonamide
9.1 4-Isopropyl-N-(2-aminomethyl-indan-4-yl)-benzenesulfonamide
N-[4-(4-Isopropyl-benzenesulfonylamino)-indan-2-ylmethyl]-propionamide (1.00 g, 2.50 mmol, synthesized as described in Example 8) was dissolved in 25 mL of n-butanol and 10 mL of concentrated (6N) hydrochloric acid was added. The resulting mixture was stirred at reflux for 5 h. The solution was cooled, added to water and extracted with ethyl acetate. The aqueous solution was treated with NaOH (2N) and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered, and the filtrate was evaporated in vacuo to give product as a white solid which was further purified by column chromatography using (dichloromethane-MeOH, 5-50%) to give a yellow oil (160 mg, 18%).
MS (ESI) m/z: 345.5 [M+H]+
9.2 4-Isopropyl-N-(2-allylaminomethyl-indan-4-yl)-benzenesulfonamide
4-Isopropyl-N-(2-aminomethyl-indan-4-yl)-benzenesulfonamide (80 mg, 0.23 mmol), allyl bromide (30 mg, 0.23 mmol) and triethylamine (20 mg, 0.23 mmol) were dissolved in 2 mL of DMF and stirred at room temperature for 18 h. The solution was concentrated, water added and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered and the filtrate was evaporated in vacuo to give a residue which was purified by column chromatography using (dichloromethane-MeOH, 0-5%) to give a yellow oil (10 mg, 6%).
MS (ESI) m/z: 385.1 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7:69 (d, 2H), 7.25 (d, 2H), 6.93 (d, 1H), 6.88 (s, 1H), 6.73 (d, 1H), 5.92 (m, 1H), 5.20 (m, 2H), 3.36 (d, 2H), 2.96 (m, 3H), 2.74 (m, 2H), 2.60 (m, 2H), 1.55 (m, 2H), 1.25 (d, 6H).
Example 10
4-Isopropyl-N-(1-propylaminomethyl-indan-5-yl)-benzenesulfonamide
10.1 N-(5-Bromo-indan-1-ylmethyl)-propionamide
A solution of (5-bromo-indan-1-yl)-methylamine (240 mg, 0.91 mmol) and triethylamine (363 mg, 3.60 mmol) in THF (5 mL) was stirred at 5° C. and propionic anhydride (125 mg, 0.96 mmol) added dropwise. After the mixture was stirred for 18 h at room temperature, the solvent was removed and ethyl acetate/water were added. The organic layer was washed with water and dried over MgSO4. The filtrate was concentrated to give a white solid (250 mg, 97%).
MS (ESI) m/z: 401.1 [M+H]+
10.2 N-[5-(4-Isopropyl-benzenesulfonylamino)-indan-1-ylmethyl]-propionamide
N-(5-Bromo-indan-1-ylmethyl)-propionamide (280 mg, 0.99 mmol) was dissolved in THF (5 mL) and tris(dibenzylideneacetone)dipalladium (45 mg, 0.05 mmol) and tri-t-butylphosphine (10 mg, 0.05 mmol) added under N2 atmosphere. A solution of 4-isopropylbenzenesulfonyl chloride (198 mg, 0.99 mmol) and NaH (52 mg, 50% in oil) was added and the solution stirred at 150° C. for 1.5 h in a microwave.
Solution was evaporated, partitioned between ethyl acetate and water, and the organic phase separated and dried over MgSO4. The filtered solution was concentrated and separated by preparative HPLC (20-95% MeOH) to give the 2 isomeric amino products and a mixed fraction (92 mg, 22%). The product was obtained as a colorless oil (21 mg, 5%).
10.3 4-Isopropyl-N-(1-propylaminomethyl-indan-5-yl)-benzenesulfonamide
The borane reduction was carried out by the aforementioned procedure. The final product was obtained as a white solid.
MS (ESI) m/z: 387.4 [M+H]+
1H-NMR (DMSO-d6): δ [ppm] 7.69 (d, 2H), 7.26 (d, 2H), 7.07 (d, 1H), 6.98 (s, 1H), 6.80 (d, 1H), 3.30 (m, 1H), 2.90 (m, 2H), 2.88-2.65 (m, 2H), 2.65 (m, 4H), 2.28 (m, 1H), 1.81 (m, 1H), 1.55 (m, 2H), 1.25 (d, 6H), 0.88 (t, 3H).
Example 11
4-Isopropyl-N-(2-propyl-2,3,4,9-tetrahydro-1H-beta-carboline-7-yl)-benzenesulfonamide×0.3 Acetate
11.1 2-Propyl-2,3,4,9-tetrahydro-1H-beta-carboline
2,3,4,9-Tetrahydro-1H-beta-carbolin (2.5 g, 14.5 mmol) and propionaldehyde (1.06 ml, 14.5 mmol) were dissolved in THF (100 ml). Acetic acid (1.25 ml, 21.8 mmol) and sodium trisacetoxyborohydride (4.615 g, 21.8 mmol) were sequentially added to the reaction mixture and stirred for 1 h at room temperature. The reaction mixture was concentrated and the residue was dissolved in H2O (10 ml) and ethyl acetate (50 ml). The pH was adjusted to 9 by adding NaOH (2M). The organic phase was separated, dried over magnesium sulfate, filtered, and evaporated to dryness to yield the title product (2.84 g, 91%).
ESI-MS: 215.1 [M+H]+
11.2 1-(2-Propyl-1,2,3,4-tetrahydro-beta-carbolin-9-yl)-ethanone
To 2-propyl-2,3,4,9-tetrahydro-1H-beta-carboline (1.46 g, 6.81 mmol) in N,N-dimethylformamide (80 ml) was added sodiumhydride (50% in oil) (392 mg, 8.17 mmol). After 15 minutes, acetyl chloride (0.58 ml, 8.17 mmol) was added to the reaction mixture and stirring continued at room temperature overnight. The solvent was removed in vacuo.
The residue was diluted with water (50 ml) and extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield 2.4 g of crude product. The crude product was purified with silica gel chromatography with cyclohexane/ethyl acetate (80:20) as eluent to give the title product (1.15 g, 66% yield).
ESI-MS: 257.1 [M+H]+
11.3 1-(7-Nitro-2-propyl-1,2,3,4-tetrahydro-beta-carbolin-9-yl)-ethanone
To 1-(2-propyl-1,2,3,4-tetrahydro-beta-carbolin-9-yl)-ethanone (1.05 g, 4.1 mmol) in conc. H2SO4 was added KNO3 (435 mg, 4.3 mmol) in small portions at 0° C. The reaction mixture was allowed to warm up to room temperature and stirred for an additional 30 minutes. The reaction mixture was poured onto 250 ml of ice and extracted once with ethyl acetate. The aqueous phase was made alkaline and extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield 1.2 g of crude product (70% purity).
ESI-MS: 303.1 [M+H]+
11.4 2-Propyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ylamine
To 1-(7-nitro-2-propyl-1,2,3,4-tetrahydro-beta-carbolin-9-yl)-ethanone (1.2 g, 2.79 mmol, 70% purity) in methanol (50 ml) was added tin dichloride (5.03 g, 22.3 mmol) and the reaction mixture was refluxed for 3 h. The solvent was removed, the residue treated with 1 N aqueous sodium hydroxide and ethyl acetate, filtered through celite, the phases separated and the aqueous phase extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield 700 mg of crude product. The crude product was purified with silica gel chromatography with ethyl acetate/methanol (95:5) as eluent to give the desired product (300 mg, 45% yield).
ESI-MS: 230.1 [M+H]+
1H-NMR (CDCl3, 400 MHz): δ [ppm] 7.3 (d, 1H), 6.6 (s, 1H), 6.5 (d, 1H), 3.6 (m, 2H), 2.8 (m, 2H), 2.7 (m, 2H), 2.5 (m, 2H), 1.6 (m, 2H), 0.9 (m, 3H).
11.5 4-Isopropyl-N-(2-propyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-yl)-benzenesulfonamide×0.3 Acetate
2-Propyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-ylamine (100 mg, 0.41 mmol) and 4-isopropyl-phenyl-sulfonyl chloride (91 mg, 0.41 mmol) were dissolved in tetrahydrofuran (15 ml). Triethylamine (0.17 ml, 1.24 mmol) was added and the reaction mixture stirred over night at room temperature. The solvent was evaporated under reduced pressure, the residue treated with H2O and extracted twice with ethyl acetate (50 ml). The organic layer was dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give the crude product. The crude product was purified via preparative HPLC (DeltaPak, 40 mm diameter) with acetonitrile/water/0.01% acetic acid as eluent to give the desired product (40 mg, 22% yield)
ESI-MS: 412.1 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.6 (bs; 1H), 9.8 (bs, 1H), 7.6 (d, 2H), 7.4 (d, 2H), 7.2 (d, 1H), 7.1 (s, 1H), 6.7 (dd, 1H), 3.5 (bs, 2H), 2.9 (sept, 6H), 2.7 (m, 2H), 2.6 (m, 2H), 2.5 (m, 2H), 1.9 (bs, 1H), 1.5 (m, 2H), 1.2 (d, 6H), 0.9 (t, 3H).
13C-NMR (DMSO-d6, 100 MHz): δ [ppm] 172.1 (s), 153.1 (s), 137.3 (s), 135.8 (s), 130.8 (s), 126.9 (d), 126.8 (d), 124.0 (s), 117.4 (d), 113.4 (d), 106.4 (s), 104.1 (d), 59.0 (t), 50.7 (t), 49.9 (t), 33.2 (d), 23.4 (q), 21.0 (t), 19.9 (t), 11.7 (q).
Example 12
4-Isopropyl-N-(2-propyl-2,3,4,4a,9,9a-hexahydro-1H-beta-carbolin-7-yl)-benzenesulfonamide
To 4-isopropyl-N-(2-propyl-2,3,4,9-tetrahydro-1H-beta-carbolin-7-yl)-benzenesulfonamide (25 mg, 0.05 mmol) in trifluoro-acetic acid (5 ml) was added sodium cyanoborohydride (15 mg, 0.24 mmol). After 15 min of stirring at room temperature the reaction mixture was made alkaline and extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield the crude product. Trifluoroacetic acid was added and the product lyophilised (6.4 mg, 24% yield).
ESI-MS: 414.1 [M+H]+
Example 13
N-(6,8-Dichloro-2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-4-isopropyl-benzenesulfonamide, hydrochloride
13.1 6,8-Dichloro-2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl-amine
6,8-Dichloro-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-ylamine (275 mg, 1.07 mmol) and propionaldehyde (81 μl, 1.12 mmol) were dissolved in tetrahydrofuran (25 ml). Acetic acid (90 μl, 1.6 mmol) and sodium trisacetoxyborohydride (340 mg, 1.6 mmol) were sequentially added to the reaction mixture and stirred for 1 hour at room temperature. The reaction mixture was concentrated and the residue was dissolved in a 1 M NaOH solution (20 ml) and ethyl acetate (20 ml). The aqueous phase was extracted once more with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield the pure product (295 mg, 92%).
ESI-MS: 299.05 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 7.05 (s, 1H), 5.2 (s, 2H), 3.25 (m, 1H), 3.1 (m, 1H), 3.0 (m, 1H), 2.65 (m, 1H), 2.6 (m, 1H), 2.45 (m, 1H), 2.3 (m, 2H), 2.15 (m, 1H), 2.05 (m, 1H), 1.65 (m, 1H), 1.5 (m, 1H), 1.45 (m, 2H), 0.85 (m, 1H).
13.2 N-(6,8-Dichloro-2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-4-isopropyl-benzenesulfonamide, hydrochloride
6,8-Dichloro-2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl-amine (100 mg, 0.33 mmol) and polystyrene-bound DMAP (4-(N,N-dimethylamino)pyridine) (loading 1.06 mmol/g, 32 mg) were treated with tetrahydrofuran (10 ml). Subsequently isopropylphenylsulfonyl chloride (73 mg, 0.33 mmol) was added and stirred for 5 hours at 150° C. in the microwave (CEM). Another portion of isopropylphenylsulfonyl chloride and polystyrene-bound DMAP was added and stirring continued for 7 hours at 160° C. in the microwave. The solvent was evaporated under reduced pressure, the residue treated with water (30 ml) and twice extracted with ethyl acetate (2×30 ml). The organic layer was dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give an oil (470 mg). The crude product was purified via HPLC chromatography. Fractions containing the product were combined and the solvent evaporated. The residue was converted into the hydrochloride salt (4 mg, 2%).
ESI-MS: 481.15/483.15 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.4 (bs, 1H), 9.95 (s, 1H), 7.7 (d, 2H), 7.45 (m, 3H), 4.1 (m, 0.5H), 3.85 (m, 0.5H), 3.7 (m, 0.5H), 3.55 (m, 0.5H), 3.45 (m, 1H), 3.1 (m, 2H), 3.0 (sept, 1H), 2.95-2.55 (m, 5H), 1.85 (m, 1H), 1.65 (m, 3H), 1.2 (d, 6H), 0.9 (t, 3H).
Example 14
4-Isopropyl-N-(2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-benzenesulfonamide, hydrochloride
14.1 2-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl-amine
A mixture of 6,8-dichloro-2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl-amine (800 mg, 2.67 mmol) and 20% palladiumhydroxide on carbon in methanol (50 ml) was hydrogenated over night at room temperature. The catalyst was filtered, and the solvent was removed under vacuum to yield the crude product. The residue was dissolved in ethyl acetate and 1 M NaOH solution. The aqueous phase was once more extracted with ethyl acetate. The combined organic layers were dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give the pure product (530 mg, 86%).
ESI-MS: 231.15 [M+H]+
14.2 4-Isopropyl-N-(2-propyl-2,3,3a,4′,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-benzenesulfonamide, hydrochloride
2-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl-amine (40 mg, 0.17 mmol) and 4-isopropylphenylsulfonyl chloride (38 mg, 0.17 mmol) were dissolved in tetrahydrofuran (20 ml). Triethylamine (70 μl, 0.52 mmol) was added and the reaction mixture stirred over night at room temperature. The solvent was evaporated under reduced pressure, the residue treated with water (30 ml) and ethyl acetate (30 ml). The aqueous phase was once more extracted with ethyl acetate and the combined organic phases were dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to give the crude product (120 mg). The crude product was purified via silica gel chromatography with cyclohexane/ethyl acetate (gradient 0-100%). Fractions containing the product were combined and the solvent evaporated to yield the pure product which was converted into its hydrochloride salt (15 mg, 18%).
ESI-MS: 413.2 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.4 (bs, 1H), 10.2 (s, 1H), 7.7 (d, 2H), 7.45 (d, 2H), 7.05 (d, 1H), 6.95 (d, 1H), 6.9 (m, 2H), 3.9 (m, 1H), 3.4 (m, 2H), 3.05 (m, 2H), 2.95 (sept, 1H), 2.8 (m, 1H), 2.6 (m, 4H), 1.65 (m, 4H), 1.2 (d, 6H), 0.9 (t, 3H).
Example 15
N-(2-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-4-(2,2,2-trifluoro-1-methylethyl)-benzenesulfonamide, hydrochloride
Following a procedure analogous to that described in example 14 the title compound was obtained.
ESI-MS: 467.25 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.7 (bs, 1H), 10.3 (m, 1H), 7.8 (d, 2H), 7.6 (d, 2H), 7.05 (m, 1H), 6.95 (d, 1H), 6.9 (m, 1H), 3.9 (m, 2H), 3.4 (m, 2H), 3.05 (m, 2H), 2.8 (m, 1H), 2.6 (m, 4H), 1.7 (m, 4H), 1.45 (m, 3H), 0.9 (m, 3H).
Example 16
N-(2-Propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-4-trifluoromethoxy-benzenesulfonamide hydrochloride
Following a procedure analogous to that described in example 14 the title compound was obtained.
ESI-MS: 455.15 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.4 (s, 1H), 10.3 (bs, 1H), 7.9 (d, 2H), 7.6 (d, 2H), 7.05 (d, 1H), 6.9 (m, 3H), 3.9 (m, 1H), 3.45 (m, 2H), 3.05 (m, 2H), 2.85 (m, 1H), 2.6 (m, 4H), 1.65 (m, 4H), 0.9 (m, 3H).
Example 17
4-Difluoromethoxy-N-(2-propyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-7-yl)-benzenesulfonamide, hydrochloride
Following a procedure analogous to that described in example 14 the title compound was obtained.
ESI-MS: 437.15 [M+H]+
1H-NMR (DMSO-d6, 400 MHz): δ [ppm] 10.65 (bs, 1H), 10.3 (s, 1H), 7.85 (d, 2H), 7.4 (t, J=70 Hz, 1H), 7.35 (d, 2H), 7.05 (d, 1H), 6.95 (m, 3H), 3.85 (m, 1H), 3.45 (m, 2H), 3.05 (m, 2H), 2.8 (m, 1H), 2.6 (m, 4H), 1.7 (m, 4H), 0.9 (m, 3H).
III. Examples of Galenic Administration Forms
A) Tablets
Tablets of the following composition are pressed on a tablet press in the customary manner:














40
mg
of substance from Example 8


120
mg
of corn starch


13.5
mg
of gelatin


45
mg
of lactose


2.25
mg
of Aerosil ® (chemically pure silicic acid in




submicroscopically fine dispersion)


6.75
mg
of potato starch (as a 6% paste)









B) Sugar-Coated Tablets













20 mg
of substance from Example 8


60 mg
of core composition


70 mg
of saccharification composition









The core composition consists of 9 parts of corn starch, 3 parts of lactose and 1 part of 60:40 vinylpyrrolidone/vinyl acetate copolymer. The saccharification composition consists of 5 parts of cane sugar, 2 parts of corn starch, 2 parts of calcium carbonate and 1 part of talc. The sugar-coated tablets which had been prepared in this way are subsequently provided with a gastric juice-resistant coating.
IV. Biological Investigations
Receptor Binding Studies:
The substance to be tested was either dissolved in methanol/Chremophor® (BASF-AG) or in dimethyl sulfoxide and then diluted with water to the desired concentration.
Dopamine D3 Receptor:
The assay mixture (0.250 ml) was composed of membranes derived from  ̃106 HEK-293 cells possessing stably expressed human dopamine D3 receptors, 0.1 nM [125I]-iodosulpride and incubation buffer (total binding) or, in addition, test substance (inhibition curve) or 1 μM spiperone (nonspecific binding). Each assay mixture was run in triplicate.
The incubation buffer contained 50 mM tris, 120 mM NaCl, 5 mM KCl, 2 mM CaCl2, 2 mM MgCl2 and 0.1% bovine serum albumin, 10 μM quinolone and 0.1% ascorbic acid (prepared fresh daily). The buffer was adjusted to pH 7.4 with HCl.
Dopamine D2L Receptor:
The assay mixture (1 ml) was composed of membranes from  ̃106 HEK-293 cells possessing stably expressed human dopamine D2L receptors (long isoform) and 0.01 nM [125I] iodospiperone and incubation buffer (total binding) or, in addition, test substance (inhibition curve) or 1 μM haloperidol (nonspecific binding). Each assay mixture was run in triplicate.
The incubation buffer contained 50 mM tris, 120 mM NaCl, 5 mM KCl, 2 mM CaCl2, 2 mM MgCl2 and 0.1% bovine serum albumin. The buffer was adjusted to pH 7.4 with HCl.
Measurement and Analysis:
After having been incubated at 25° C. for 60 minutes, the assay mixtures were filtered through a Whatman GF/B glass fiber filter under vacuum using a cell collecting device. The filters were transferred to scintillation viols using a filter transfer system. After 4 ml of Ultima Gold® (Packard) have been added, the samples were shaken for one hour and the radioactivity was then counted in a Beta-Counter (Packard, Tricarb 2000 or 2200CA). The cpm values were converted into dpm using a standard quench series and the program belonging to the instrument.
The inhibition curves were analyzed by means of iterative nonlinear regression analysis using the Statistical Analysis System (SAS) which is similar to the “LIGAND” program described by Munson and Rodbard.
The results of the receptor binding studies are expressed as receptor binding constants Ki(D2) and Ki(D3), respectively, as herein before described, and given in table 1.
In these tests, the compounds according to the invention exhibit very good affinities for the D3 receptor (<10 nM, frequently <5 nM) and bind selectively to the D3 receptor.
The results of the binding tests are given in table 1.










TABLE 1





Example
Ki(D3)* [nM]
Ki(D2)* [nM]
Ki(D2)*/Ki(D3)*


















1
5.8
225
39


2
9.4
517
55


3
55
55
23


4
63.4
7,640
120


5
1.72
119
69


7
7.4
398
54


9
4.3
232
54


10
1.32
58.6
45


12
5.3
137
26


13
10.1

5


14
0.5

28


15
1.8

36


16
3.6

66


17
3.3

19





*Receptor binding constants obtained according to the assays described herein before

## Claims

1. An aminomethyl substituted bicyclic aromatic compound of the formula I



wherein
Ar is a cyclic radical selected from the group consisting of phenyl and a 5- or 6-membered C-bound heteroaromatic radical comprising as ring members 1, 2 or 3 heteroatoms which are, independently of each other, selected from O, S and N, where the cyclic radical Ar may carry 1, 2 or 3 substituents Ra;
Ra is halogen, C1-C6-alkyl, fluorinated C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkenyl, fluorinated C1-C6-alkenyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C1-C6-alkoxy, C1-C6-hydroxyalkoxy, C1-C6-alkoxy-C1-C6-alkoxy, fluorinated C1-C6-alkoxy, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfinyl, fluorinated C1-C6-alkylsulfinyl, C1-C1-alkylsulfonyl, fluorinated C1-C6-alkylsulfonyl, CN, nitro, C1-C6-alkylcarbonyl, fluorinated C1-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, carboxy, NH—C(O)—NR4R5, NR4R5, NR4R5-C1-C6-alkylene, O—NR4R5, C(O)NR4R5, SO2NR4R5, phenylsulfonyl, benzyloxy, phenoxy, or a saturated or unsaturated 3- to 7-membered heterocyclic ring comprising as ring members 1, 2, 3 or 4 heteroatoms selected from N, O and S and/or 1, 2 or 3 heteroatom-containing groups selected from NR9, where R9 has one of the meanings given for R8, SO, SO, and CO, and where the 5 last-mentioned radicals Ra may carry 1, 2, 3 or 4 substituents selected from hydroxy and the radicals Ra;
X is a covalent bond or N—R2, CHR2, CHR2CH2, N or C—R2;
Y is N—R2a, CHR2a, CHR2aCH, or CHR2aCH2CH2;
 is a single bond or a double bond;
E is CH2 or NR3;
R1 is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4-alkenyl, formyl or C1-C3-alkylcarbonyl;
R1a is H, C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl, or fluorinated C3-C4-alkenyl,
R2 and R2a each independently are H, CH3, CH2F, CHF, or CF3 or R1a and R2 or R1a and R2a together are (CH2)n with n being 1, 2 or 3;
R3 is H or C1-C4-alkyl;
R4 and R5 independently of each other are H, C1-C4-alkyl, fluorinated C1-C4-alkyl or C1-C4-alkoxy or may form, together with N, a 4-, 5- or 6-membered saturated or unsaturated ring;
R6 and R7 independently of each other are H or halogen;
or physiologically tolerated acid addition salts thereof.

2. The compound as claimed in claim 1, of the formula I.1



wherein
Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, comprising 1 nitrogen atom as ring member and 0, 1, 2 or 3 further heteroatoms, independently of each other, selected from 0, S and N, as ring members, wherein Ar may carry 1, 2 or 3 radicals Ra which are, independently of each other, selected from the group consisting of halogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-alkoxy, fluorinated C1-C6-alkyl, fluorinated C3-C6-cycloalkyl, fluorinated C1-C6-alkoxy, NR4R5, 1-aziridinyl, azetidin-1-yl, pyrrolidin-1-yl or piperidin-1-yl, wherein the last four mentioned radicals may be fluorinated, and an aromatic 5- or 6-membered C-bound heteroaromatic radical, comprising 1 nitrogen atom as ring member and 0, 1, 2 or 3 further heteroatoms, independently of each other, selected from 0, S and N, wherein the last mentioned radical may carry 1, 2, 3 or 4 radicals selected from halogen and the radicals Ra;
R4 and R5, independently of each other, are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl; and
X, Y, , E, R1, R1a, R2, R2a and R3 are as defined in claim 1.

3. The compound as claimed in claim 1, wherein Ar carries one radical Ra of the formula Ra′



wherein
Y is N, CH or CF,
Ra1 and Ra2 are independently of each other selected from C1-C2-alkyl, fluorinated C1-C2-alkyl, or provided for Y being CH or CF one of the radicals Ra1 or Ra2 may also be hydrogen or fluorine, or
Ra1 and Ra2 together form a radical (CH2)m wherein 1 or 2 of the hydrogen atoms may be replaced by fluorine, hydroxy, oxo, C1-C2-alkyl or C1-C2-alkoxy, wherein one CH2 moiety may be replaced by O, S, S═O, SO2 or N—Rc, Rc being hydrogen or C1-C2-alkyl and wherein m is 2, 3, 4, 5 or 6.

4. The compound as claimed in claim 3, wherein the radical Ra′ is selected from isopropyl, (R)-1-fluoroethyl, (S)-1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, (R)-1-fluoropropyl, (S)-1-fluoropropyl, (R)-2-fluoropropyl, (S)-2-fluoropropyl, 3-fluoropropyl, 1,1-difluoropropyl, 2,2-difluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, (R)-2-fluoro-1-methylethyl, (S)-2-fluoro-1-methylethyl, (R)-2,2-difluoro-1-methylethyl, (S)-2,2-difluoro-1-methylethyl, (R)-1,2-difluoro-1-methylethyl, (S)-1,2-difluoro-1-methylethyl, (R)-2,2,2-trifluoro-1-methylethyl, (S)-2,2,2-trifluoro-1-methylethyl, 2-fluoro-1-(fluoromethyl)ethyl, 1-(difluoromethyl)-2,2-difluoroethyl, cyclopropyl, cyclobutyl, 1-fluorocyclopropyl, (R)- and (S)-2,2-difluorocyclopropyl, (R)- and (S)-2-fluorocyclopropyl.

5. The compound as claimed in claim 3, wherein the radical Ra′ is selected from 4-morpholinyl, 4-thiomorpholinyl, 4-(1,1-dioxo)thiomorpholinyl, piperazin-1-yl, 4-methylpiperazin-1-yl, azetidin-1-yl, 2-methylazetidin-1-yl, (S)-2-methylazetidin-1-yl, (R)-2-methylazetidin-1-yl, 3-fluoroazetidin-1-yl, 3-methoxyazetidin-1-yl, 3-hydroxyazetidin-1-yl, pyrrolidin-1-yl, pyrrolidin-2-yl, (S)-pyrrolidin-2-yl, (R)-pyrrolidin-2-yl, pyrrolidin-3-yl, (S)-pyrrolidin-3-yl, (R)-pyrrolidin-3-yl, 2-fluoropyrrolidin-1-yl, (S)-2-fluoropyrrolidin-1-yl, (R)-2-fluoropyrrolidin-1-yl, 3-fluoropyrrolidin-1-yl, (S)-3-fluoropyrrolidin-1-yl, (R)-3-fluoropyrrolidin-1-yl, 2,2-difluoropyrrolidin-1-yl, 3,3-difluoropyrrolidin-1-yl, 2-methylpyrrolidin-1-yl, (S)-2-methylpyrrolidin-1-yl, (R)-2-methylpyrrolidin-1-yl, 3-methylpyrrolidin-1-yl, (S)-3-methylpyrrolidin-1-yl, (R)-3-methylpyrrolidin-1-yl, 1-methylpyrrolidin-2-yl, (S)-1-methylpyrrolidin-2-yl, (R)-1-methylpyrrolidin-2-yl, 1-methylpyrrolidin-3-yl, (S)-1-methylpyrrolidin-3-yl, (R)-1-methylpyrrolidin-3-yl, 2,2-dimethylpyrrolidin-1-yl, 3,3-dimethylpyrrolidin-1-yl, 2-trifluoromethylpyrrolidin-1-yl, (S)-2-trifluoromethylpyrrolidin-1-yl, (R)-2-trifluoromethylpyrrolidin-1-yl, 3-trifluoromethylpyrrolidin-1-yl, (S)-3-trifluoromethylpyrrolidin-1-yl, (R)-3-trifluoromethylpyrrolidin-1-yl, 2-oxopyrrolidin-1-yl, 2-oxo-oxazolidin-3-yl, piperidin-1-yl, 2-methylpiperidin-1-yl, (S)-2-methylpiperidin-1-yl and (R)-2-methylpiperidin-1-yl.

6. The compound as claimed in claim 3, wherein the radical Ra′ carries 1, 2, 3 or 4 fluorine atoms.

7. The compound as claimed in claim 1, where Ra′ is selected from OCH2F, OCHF2 and OCF3.

8. The compound as claimed in claim 1, wherein Ar carries one radical Ra, which is selected from 5- or 6-membered heteroaromatic radicals having as ring members 1 heteroatom selected from 0, S and N and which may further have 1, 2 or 3 nitrogen atoms as ring members, and wherein the 5- or 6-membered heteroaromatic radical may carry 1, 2 or 3 substituents selected from halogen, NO2, NH2, OH, CN, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C11-alkoxy, fluorinated C1-C6-alkyl, fluorinated C3-C6-cycloalkyl, fluorinated C1-C6-alkoxy, C1-C6-hydroxyalkyl, C1-C4-alkoxy-C2-C4-alkyl, C1-C6-hydroxyalkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C6-alkylcarbonyl, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkylaminocarbonyl, di-C1-C6-alkylaminocarbonyl, fluorinated C1-C6-alkylcarbonyl, C1-C6-alkylcarbonylamino, fluorinated C1-C6-alkylcarbonylamino, C1-C6-alkylcarbonyloxy, fluorinated C1-C6-alkylcarbonyloxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, fluorinated C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, fluorinated C1-C6-alkylsulfinyl and fluorinated C1-C6-alkylsulfonyl.

9. The compound as claimed in claim 8, wherein Ar carries one heteroaromatic radical Ra, which is selected from furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, 1,3,4-thiadiazolyl, 1,2,4-triazolyl, 1,2,3-triazolyl and tetrazolyl, where the heteroaromatic radical may be unsubstituted or may carry 1 to 3 substituents selected from halogen, C1-C4-alkyl, C1-C4-alkoxy, fluorinated C1-C4-alkyl and fluorinated C1-C4-alkoxy.

10. The compound as claimed in claim 1, wherein Ar is phenyl.

11. The compound as claimed in claim 1, wherein Ar is phenyl that carries a radical Ra in the 4-position of the phenyl ring.

12. The compounds as claimed in claim 1, wherein E is NR3.

13. The compounds as claimed in claim 1, wherein E is CH2.

14. The compound as claimed in claim 1, wherein X is CH, and Y is CH, or CH2CH2.

15. The compound as claimed in claim 1, wherein Y is NH and X is CH or N.

16. The compound as claimed in claim 1, wherein Y is CH2CH2 or CH2CH2CH, and X is a covalent bond.

17. The compound as claimed in claim 1, wherein X is NH and Y is CH2.

18. The compound as claimed in claim 1, wherein R1 is C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4-cycloalkyl or fluorinated C3-C4-alkenyl.

19. The compound as claimed in claim 1, wherein R1a is hydrogen.

20. The compound as claimed in claim 1, wherein R1a is C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C2-C4-alkyl, fluorinated C3-C4-cycloalkyl or fluorinated C3-C4alkenyl.

21. The compound as claimed in claim 1, wherein X is CHR2 or CHR2CH2 and R1a and R2 together are (CH2)n with n being 1, 2 or 3.

22. The compound as claimed in claim 1, wherein Y is CHR2a, CHR2aCH, or CHR2aCH2CH2 and R1a and R2a together are (CH2)n with n being 1, 2 or 3.

23. The compound as claimed in claim 1, wherein X is a covalent bond, Y is CHR2aCH2CH2 and R1a and R2a together are (CH2).

24. A pharmaceutical composition comprising at least one compound as claimed in claim 1, optionally together with at least one physiologically acceptable carrier or auxiliary substance.

25. A method for treating one or more of the acute signs, chronic signs, symptoms or malfunctions of a medical disorder selected from Parkinson's disease, schizophrenia, impaired learning and memory, depression, anxiety, psychic disorders and behavioral disturbances caused by the abuse of psychotropic substances, and diabetic nephropathy, said method comprising administering an effective amount of at least one compound as claimed in claim 1 to a subject in need thereof.

26. The method as claimed in claim 25, wherein the medical disorder is schizophrenia.