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Title:   Author  item
                                            HORNE, WILLY - TEXAS A&M UNIVERSITYitem
                                            BARLING, KEVIN - TEXAS A&M UNIVERSITYitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            HERRING, ANDY - TEXAS A&M UNIVERSITYitem
                                            SAWYER, JASON - TEXAS A&M UNIVERSITY
  Submitted to: American Dairy Science Association Abstracts
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/11/2008
                                    Publication  Date: 7/25/2008
                                    Citation: Horne, W., Barling, K., Carroll, J.A., Herring, A., Sawyer, J. 2008. Evaluation of the acute phase response in the neonate bovine model following vaccination against bovine respiratory disease complex [abstract]. Journal of Animal Science. 96:(E. Suppl. 2):200. (Abstract #W27)Interpretive Summary:
                                Technical Abstract: A study using 7-d old Holstein calves was conducted to determine the effects of viral vaccination on febrile and pro-inflammatory cytokine responses in the neonate. Calves were treated with a multi-valent modified live virus vaccine (Arsenal 4.1®, n = 3; ML) or a multi-valent killed virus vaccine (ViraShield 6®, n = 3; KV) within a week of birth at label dosage. Blood samples and rectal temperatures (RT) were collected 1 h before, hourly for 12 h, at 18, 24, 30, 36, 48, 60, and 72 h after vaccines were administered. Serum was analyzed for tumor necrosis factor-alpha (TNF-a), interferon-gamma (IFN-g), interleukin 1-beta (IL-1), interleukin 2 (IL-2), interleukin 4 (IL-4), and interleukin 6 (IL-6). Responses were evaluated as difference from baseline within calf. Data were analyzed as repeated measures with calf as the subject. Time influenced (P < 0.1) all responses except serum IL-4 (P = 0.18). Peak increases in TNF-a, IL-6, and IFN-g occurred at 24 h, with IFN-g falling below baseline at 48 h; IL-6 remained elevated through 60 h. Increased IL-2 was observed at 0, 30,36, 60, and 72 h after vaccination. Treatment by time interactions occurred for RT (P = 0.04) and IL-1 (P = 0.05). After 6 h, all calves had elevated RT, but the magnitude of increase was greater for calves receiving ML than those receiving KV. Increase in IL-1 was of greater magnitude in the first 12 h for calves receiving KV, but returned to baseline after 24 h. For those receiving ML, IL-1 increased at 5 and 6 h, returned to baseline, then increased after 30 h. Animals receiving ML had greater increases (P = 0.07) in serum IL-4 concentrations than those receiving KV. However, KV inspired greater (P = 0.02) increases in IL-6. Both vaccines stimulated cytokine production. The febrile response does not appear to be well correlated with the release of any specific cytokine. Vaccines have differential effects on the magnitude and timing of release of various cytokines. Understanding these differences and immunological sequelae to cytokine release may enhance development of vaccination strategies.


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