U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Sonstegard, Taditem
                                            Liu, Ge

                                                         - *George*item
                                            MATUKUMALLI, LAKSHMI - GEORGE MASON UNIVERSITYitem
                                            Van Tassell, Curtis

                                                         - *Curt*
  Submitted to: Animal Breeding and Animal Genetic Resources Proceedings
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 11/27/2007
                                    Publication  Date: 12/5/2007
                                    Citation: Sonstegard, T.S., Liu, G., Matukumalli, L.K., Van Tassell, C.P. 2007. Snps to chips: changing the paradigm of mapping and selection in cattle. [abstracat].Animal Breeding and Animal Genetic Resources Proceedings.Interpretive Summary: This paper presents an overview of the strategies that have been and currently are being used to develop tools for applied genomics in cattle. The long term goal of this research is to gain an understanding of the genetic component of phenotypic variation to facilitate stable changes in production, fertility and health through selection.  This goal aligns completely with the application-based goal for genetic improvement in the U.S. dairy industry, which is to select animals based on DNA marker information in order to account for the substantial variation inherent in quantitative genetic approaches of selection.  The economic value of research to the U.S. dairy industry stems from the potential of marker-assisted selection (MAS) to shorten generation intervals and reduce the cost of progeny testing by more accurately distinguishing animals with desired allele combinations for well-defined selection objectives.  Further characterization of the genome will enhance research into MAS solutions, and will provide substantial information to other livestock researchers attempting to better understand how genetic variation affects phenotype.
                                Technical Abstract: The past 25 years of research on the cattle genome has focused on DNA marker based tools that can be applied to genetic improvement in cattle.  However, the paradigm of marker assisted selection for complex traits has recently shifted from focusing on genetic variation contained in specific quantitative trait loci (QTL) regions to genome-wide information.  This shift is due in part, to the availability of the draft sequence assembly of the bovine genome and corresponding resources for high throughput single nucleotide polymorphism (SNP) based genotyping on a genome-wide basis.  Dense marker information applied directly to current industry breeding schemes promises to provide better accuracy of predictions of genetic merit; while enhancing heritability and reliability of these predictions through improved pedigree information.  We present an overview of this paradigm shift with an emphasis on the development and use of a bovine 58K SNP chip, and also include discussion on additional genomic tools that will better characterize the structure and function of the bovine genome.  Delivery of knowledge and tools like the 58K SNP chip to industry partners will facilitate genome-wide selection for immediate application to progeny test bulls; thus, changing the way the U.S. dairy industry practices selection for genetic improvement.  The subsequent genome information generated from these applied efforts will also enhance both the detection of novel QTL for traits of importance to cattle and the development of tools that accelerate gene discovery.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov