U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Livestock Issues Research: Lubbock, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    NewsletterSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area Lubbock, Texas Cropping Systems Research Laboratory Livestock Issues Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            JENKINS, SARA - University Of Tennesseeitem
                                            COOPER, TABATHA - University Of Tennesseeitem
                                            ROBERTS, MARY - University Of Tennesseeitem
                                            MATHEW, ALAN - University Of Tennesseeitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            KATTESH, HANK - University Of Tennesseeitem
                                            KOJIMA, CHERYL - University Of Tennessee
  Submitted to: Journal of Animal and Veterinary Advances
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 9/30/2009
                                    Publication  Date: 10/21/2009
                                    Citation: Jenkins, S.J., Cooper, T.A., Roberts, M.P., Mathew, A.G., Carroll, J.A., Kattesh, H.G., Kojima, C.J. 2009. Effects of Syndyphalin-33 on immune function during a Salmonella challenge in recently weaned pigs. Journal of Animal and Veterinary Advances. 8(12):2562-2567.Interpretive Summary: The process of weaning pigs involves many stressors, and the proliferation and introduction of a pathogen occurs more readily in new weaned pigs moved to a nursery facility. Therefore, a collaborative study with scientists from ARS and the University of Tennessee was conducted to evaluate the effects of Syndyphalin-33 (SD-33), a synthetic enkephalin with prolonged analgesic activity that has the ability to increase feed intake (FI), on immune cell populations with and without a concurrent inoculation with a common enteric pathogen, Salmonella enterica. Collectively, the results of this preliminary study suggest that the synthetic opioid SD-33 may modulate the immune axis in recently weaned pigs. The results also demonstrate that although co-treatment with SD-33 during an immune challenge did not result in increased feed intake, SD-33 exerted effects relating to circulating populations of immune cells that may enhance the ability of newly weaned pigs to cope with pathogenic challenges during this stressful period. Further work is needed to determine if this compound could potentially be uses as a management tool to enhance the overall well-being and productivity of newly weaned pigs.
                                Technical Abstract: The objective of this experiment was to characterize the effect of Syndyphalin-33 (SD-33) on immune cell populations with and without a concurrent inoculation with a common enteric pathogen, Salmonella enterica (SALM) in recently weaned pigs. On d 0, pigs (8 barrows and 6 gilts, 24 ± 1 d of age, 8.43 ± 0.82 kg) were weaned and fitted with jugular catheters. The following day, pigs were administered either SD-33 (0.5 micromole/kg, given i.m.) or saline (VEH; 0.5 mL, given i.m.) and SALM (oral gavage of 5 x 500 million CFU) or sterile broth (CON; 3 mL oral gavage) in a factorial arrangement such that 4 treatment groups existed: VEH+CON (n = 4), SD-33+CON (n = 3), VEH+SALM (n = 3), and SD-33+SALM (n = 4). There were no differences in feed intake (FI) or body weight (BW) among the SALM treated animals over time (P > 0.05). Cumulatively, FI among the SD-33+CON pigs was greater (P < 0.05) compared to the SD-33+SALM pigs. White blood cell (WBC) populations increased (P < 0.05) over the 4 d post-injection period. On d 2 post-challenge, circulating neutrophils and lymphocytes were lower (P < 0.05) in VEH+SALM but not in SD-33+SALM pigs relative to VEH+CON and SD-33+CON pigs, demonstrating the ability of SD-33 to abrogate the affect of Salmonella. Also, on d 2 post-challenge, circulating monocyte populations were greater (P < 0.05) in pigs receiving SD-33 relative to controls regardless of Salmonella treatment. The results of this preliminary study suggest that the opioid SD-33 may modulate the immune axis in recently weaned pigs.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov