U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Location Research Units
                        National Sedimentation Laboratory
                                    Natural Products Utilization Research Unit
                                    Water Quality and Ecology Research Unit
                                    Watershed Physical Processes Research UnitSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            NANAYAKKARA, DHAMMIKA N.P. - UNIVERSITY OF MISSISSIPPIitem
                                            Schrader, Kevin
  Submitted to: Journal of Agricultural and Food Chemistry
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/30/2007
                                    Publication  Date: 1/19/2008
                                    Citation: Nanayakkara, D., Schrader, K. 2008. Synthesis of Water-soluble 9,10-Anthraquinone Analogues with Potent Cyanobactericidal Activity Toward the Musty-Odor Cyanobacterium Oscillatoria perornata. Journal of Agricultural and Food Chemistry. 56:1002-1007.Interpretive Summary: Water-soluble analogs were made of a natural compound found to have selective toxicity towards the blue-green alga which causes "musty" off-flavor in pond-raised channel catfish in Mississippi, Alabama, and Arkansas.  The water-soluble forms of the natural compound were evaluated to determine which ones were most selectively toxic towards the musty blue-green alga and in relation to the chemical nature of the analog compound.
                                Technical Abstract: A series of water-soluble 9,10-anthraquinone analogs were prepared and evaluated for their selective toxicity towards Oscillatoria perornata which grows in catfish production ponds and causes “musty” off-flavor in channel catfish Ictalurus punctatus. Water-soluble mono- and dicationic salts were prepared by conjugating various small amines directly or through a methylene or ethylene bridge to the 9,10-anthraquinone nucleus. One of the dicationic salts, 2-[N-(1 ́-methyl-4 ́-N,N-diethylaminobutyl)aminometyl]anthraquinone diphosphate exhibited very high water solubility and potent selective toxicity towards O.  perornata. However, the tendency of this compound to potentially bind to suspended sediments may be the reason for its limitations in controlling O. perornata in catfish production ponds. Monocationic salt, 2-[N-(1 ́-methylethyl)]aminomethyl]anthraquinone monophosphate, showed good solubility and high selective toxicity towards O.  perornata. Neutral water-soluble analogs prepared by conjugating terta- or pentaethylene glycol directly or by a methylene bridge to the 9,10-anthraquinone nucleus had less activity than the parent compound.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov