U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Liu, Ge

                                                         - *George*item
                                            VENTURA, MARIO - University Of Bariitem
                                            CELLAMARE, ANGELO - University Of Bariitem
                                            CHEN, LIN - University Of Washingtonitem
                                            CHENG, ZE - University Of Washingtonitem
                                            ZHU, BIN - University Of Marylanditem
                                            SONG, JIUZHOU - University Of Marylanditem
                                            EICHLER, EVEN - University Of Washington
  Submitted to: Gordon Research Conference Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/14/2009
                                    Publication  Date: 7/19/2009
                                    Citation: Liu, G., Ventura, M., Cellamare, A., Chen, L., Cheng, Z., Zhu, B., Song, J., Eichler, E.E. 2009. Analysis of recent segmental duplications in the bovine genome. [abstract]. Gordon Research Conference Proceedings.Interpretive Summary:
                                Technical Abstract: Duplicated sequences are an important source of gene innovation and structural variation within mammalian genomes. We describe the first systematic and genome-wide analysis of segmental duplications in the modern domesticated cattle (Bos taurus). Using two distinct computational analyses, we estimate that 3.1% (94.4 Mb) of the bovine genome consists of recently duplicated sequences (= 1kb in length, = 90% sequence identity). Similar to other working draft assemblies almost half (47% of 94.4 Mb) of these sequences have not been assigned to cattle chromosomes, indicating that segmental duplications have been problematic for sequence and assembly of the bovine genome. We further confirmed and investigated the distribution of the largest duplications using FISH. Both experimental and computational analyses suggest that the (75-90%) of segmental duplications are organized into local tandem duplication clusters. Along with rodents and carnivores, these results now establish tandem duplications as the most likely mammalian archetypical organization, in contrast to humans and great ape species which show a preponderance of interspersed duplications. We find that bovine segmental duplications corresponding to genes are significantly enriched for specific biological functions such as immunity, rumination, lactation and reproduction. The level of sequence identity suggests that over 25% of these duplications have occurred within the artiodactylan or more-specifically within the Bos lineage of evolution with important implications in cattle speciation and adaptation.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov