U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Bearson, Bradley

                                                         - *Brad*item
                                            Bearson, Shawn
  Submitted to: Meeting Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/28/2009
                                    Publication  Date: 9/30/2009
                                    Citation: Bearson, B.L., Bearson, S.M. 2009. Differences in Pathogenesis for Salmonella enterica serovar Typhimurium in the Mouse Versus the Swine Model Identify Bacterial Gene Products Required for Systemic but not Gastrointestinal Disease. International Symposium on the Epidemiology and Control of Foodborne Pathogens in Pork, September 30-October 2, 2009, Quebec City, Canada. p. 88.Interpretive Summary:
                                Technical Abstract: Over the last several decades, the mouse model of Typhoid fever has been an extremely productive model to investigate Salmonella enterica serovar Typhimurium pathogenesis.  The mouse is the paradigm for investigating systemic disease due to infection by Salmonella; however, the swine model of gastrointestinal colonization and enteric disease due to Salmonella is better suited to address food safety.  Although certain Salmonella mutants may be attenuated for colonization and disease in both the mouse and swine model, others may only be attenuated in one of the models depending on whether the gene product is required for gastrointestinal or systemic disease.  Recent research performed on the swine model in our laboratories with comparison to the literature on the mouse model, illustrates the discrepancy between these two models.  The fepA iroN and cirA gene products of S. Typhimurium are required for iron acquisition by uptake of enterochelin, salmochelin, and their breakdown products.  In the mouse model, a S. Typhimurium mutant with deletions in the fepA iroN and cirA genes is attenuated for disease.  In contrast, no significant difference in gastrointestinal colonization or fecal shedding was found comparing a S. Typhimurium fepA iroN cirA mutant to wild-type in the swine model.  Furthermore, investigation of a two-component system for sensing the bacterial environment has demonstrated that inactivation of the qseBC (preAB) genes has a two-day delay in mouse mortality and a competitive defect in the liver and spleen compared to wild-type S. Typhimurium.  However, in the pig no significant difference was observed in fecal shedding or gastrointestinal colonization between the qseBC mutant and the wild-type strain.  The difference between these two models suggests roles in systemic but not gastrointestinal disease for these S. Typhimurium gene products and highlights the importance of utilizing the swine model for the development of Salmonella interventions to enhance pork safety.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov