U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Baker, Amyitem
                                            MA, WENJUN - IOWA STATE UNIVERSITYitem
                                            Lager, Kellyitem
                                            GRAMER, MARIE - UNIVERSITY OF MINNESOTAitem
                                            Richt, Juergenitem
                                            JANKE, BRUCE - IOWA STATE UNIVERSITY
  Submitted to: Virus Genes
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 6/30/2009
                                    Publication  Date: 10/1/2009
                                    Citation: Vincent, A.L., Ma, W., Lager, K.M., Gramer, M.R., Richt, J.A., Janke, B.H. 2009. Characterization of a Newly Emerged Genetic Cluster of H1N1 and H1N2 Swine Influenza Virus in the U.S. Virus Genes. 39(2):176-185.Interpretive Summary: Swine influenza virus (SIV) is one of the primary causes of respiratory disease in growing pigs and can lead to major economic losses to the swine industry.  In addition to SIV, pigs can become infected with influenza viruses from birds and humans and produce viruses with a mixture of genetic material.  A new type of SIV has emerged in the United States that contains genetic material from H1 human influenza viruses as well as genetic material from contemporary SIV.  In this paper, we examine the full genetic makeup of 4 of the recently emerged human-like H1 SIV and the properties of one of these viruses in a pig infection study.  Closer monitoring of pig and human populations for this and other SIV is warranted.
                                Technical Abstract: H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003-2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage.  The viruses identified in Canadian pigs were human lineage in entirety or double (human-swine) reassortants.  Here we report the whole genome sequence analysis of 4 human-like H1 viruses isolated from U.S. swine in 2005 and 2007.  All 4 isolates were characterized as triple reassortants with an internal gene constellation similar to contemporary U.S. swine influenza virus (SIV), with HA and neuraminidase (NA) most similar to human influenza virus lineages.  A 2007 human-like H1N1 was evaluated in a pathogenesis and transmission model and compared to a 2004 reassortant H1N1 SIV isolate with swine lineage HA and NA.  The 2007 isolate induced disease typical of influenza virus and was transmitted to contact pigs; however the kinetics and magnitude differed from the 2004 H1N1 SIV.  This study indicates that the human-like H1 SIV can efficiently replicate and transmit in the swine host and now co-circulates with contemporary SIVs as a distinct genetic cluster of H1 SIV.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov