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Title:   Author  item
                                            Liu, Ge

                                                         - *George*item
                                            ZHU, BIN - UNIV OF MARYLANDitem
                                            Alexander, Leesonitem
                                            MATUKUMALLI, LAKSHMI - GEORGE MASONitem
                                            Van Tassell, Curtis

                                                         - *Curt*item
                                            Sonstegard, Taditem
                                            Nonneman, Danny

                                                         - *Dan*item
                                            Keele, Johnitem
                                            Smith, Timothy

                                                         - *Tim*item
                                            Gasbarre, Louis
  Submitted to: Plant and Animal Genome Conference Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 9/26/2008
                                    Publication  Date: 1/10/2009
                                    Citation: Liu, G., Zhu, B., Alexander, L.J., Matukumalli, L.K., Van Tassell, C.P., Sonstegard, T.S., Nonneman, D.J., Keele, J.W. 2009. Studies on cattle genomic structural variation provide insights into ruminant speciation and adaptation. [abstract]. Plant and Animal Genome Conference Proceedings. W093.Interpretive Summary:
                                Technical Abstract: Genomic structural variations, including segmental duplications (SD) and copy number variations (CNV), contribute significantly to individual health and disease in primates and rodents. As a part of the bovine genome annotation effort, we performed the first genome-wide analysis of SD in cattle using two different approaches. These analyses revealed that approximately 3% (90 Mbp) of the cattle genome consists of SD. Local clusters of tandem duplications in cattle are reminiscent of the SD patterns observed in other mammals (dog, rat and mouse), but differ from the interspersed SD pattern found in primate genomes. A few gene duplications, which are important in adaptation or recent domestication, were discovered to occur within the artiodactyls or more-specifically within the Bos lineage of evolution. Selected SD events are being confirmed by independent methods using FISH. Additionally, we used array comparative genomic hybridization (array CGH) and real time PCR to study CNV in cattle. We detected hundreds of CNV events in cattle and generated the first cattle CNV map. We will discuss the strong correlations between SD and CNV and their contributions to ruminant speciation and adaptation.


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