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Title:   Author  item
                                            Cheung, Andrewitem
                                            WU, GUANG - WASHINGTON UNIVERSITYitem
                                            WANG, DAVID - WASHINGTON UNIVERSITYitem
                                            Bayles, Darrellitem
                                            Lager, Kellyitem
                                            Baker, Amy
  Submitted to: Archives of Virology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/29/2010
                                    Publication  Date: 5/1/2010
                                    Citation: Cheung, A.K., Wu, G., Wang, D., Bayles, D.O., Lager, K.M., Vincent, A.L. 2010. Identification and Molecular Cloning of a Novel Porcine Parvovirus. Archives of Virology. 155(5):801-806.Interpretive Summary: Porcine circovirus type 2 (PCV2) is an important viral pathogen of swine and it is the main culprit of several swine health problems collectively known as PCV-associated diseases. PCV2-afflicted animals when co-infected with other pathogens usually exhibit a more severe form of the disease. Here, we identified a novel porcine parvovirus, designated PPV4, among the sick animals of the 2005 USA PCVAD outbreak. Our analysis revealed several distinct characteristics of PPV4. Thus, this work provides a frame work to investigate the inter-relationship between PCV2 and PPV4 and their pathogenesis potentials. The information obtained will advance our understanding of porcine circovirus and parvovirus biology and aid the research of scientists in industry, universities and government agencies.
                                Technical Abstract: A novel porcine parvovirus, PPV4, was identified in the lung lavage of a diseased pig coinfected with porcine circovirus type 2a. Phylogenetically, this new virus is highly divergent from the three previously identified porcine parvoviruses. PPV4 exhibits limited similarity to its closest relative bovine parvovirus 2 in both open-reading- frame 1 (ORF1) that codes for the replication protein(s) and ORF2 that codes for the capsid protein(s). With respect to genome coding capacity and organization, PPV4 resembles viruses of the Bocavirus genus (bovine parvovirus 1, canine minute virus and human bocavirus). PPV4 and the Bocaviruses encode an additional ORF3, which is located in the middle of the genome between ORF1 and ORF2. PPV4 ORF3 is predicted to encode a protein of 204 amino acid residues, which is similar in size to the ORF3 encoded proteins of the Bocaviruses. However, whereas the ORF3 encoded proteins of the Bocaviruses share significant similarity with each other, the PPV4 ORF3 encoded protein does not exhibit homology with any protein in the GenBank non-redundant database.


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