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Title:   Author  item
                                            Cantrell, Charlesitem
                                            MAMONOV, L.K. - INST. PLT BIO & BIOTECHitem
                                            VASSILYEV, J.I. - INST. PLT BIO & BIOTECHitem
                                            MUKANOVA, G.S. - INST. PLT BIO & BIOTECHitem
                                            ACHMETOVA, D.S. - INST. PLT BIO & BIOTECH
  Submitted to: Book Chapter
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 4/15/2008
                                    Publication  Date: 4/15/2008
                                    Citation: Cantrell, C.L., Mamonov, L., Vassilyev, J., Mukanova, G., Achmetova, D. 2008. Revealing of Biological Activity in Crude Extracts, Seperated Fractions, Groups of Chemical Substance and Individual Compounds. Book Chapter. In: Introduction to Phytochemical Investigations and Discovering Biological Activities of Phytogenous Substances. Eds. B.M. Butin and B.A. Sarsenbaev. Institute of Plant Biology and Biotechnology, Almaty, Kazakhstan. pp. 127-157.Interpretive Summary: Crude extracts, separated fractions, groups of chemical substances, and individual compounds from natural sources are all evaluated stepwise while performing purifications in in-house bioassays.  In a stepwise fashion proceeding from crude extracts to fractions and on to pure compounds, decisions are made regarding how best to proceed based on biological evaluation results at each step.  In order to use this bioassay-guided approach, the bioassays bust not only be relatively quick but such bioassays must also be capable of quantitatively ranking activity on sub milligram quantities of material.  Natural product purifications often require the ability to work with such small sample sizes for both chemical and biological evaluations.
                                Technical Abstract: Crude extracts, separated fractions, groups of chemical substances, and individual compounds from natural sources are all evaluated stepwise while performing purifications in in-house bioassays.  In a stepwise fashion proceeding from crude extracts to fractions and on to pure compounds, decisions are made regarding how best to proceed based on biological evaluation results at each step.  In order to use this bioassay-guided approach, the bioassays bust not only be relatively quick but such bioassays must also be capable of quantitatively ranking activity on sub milligram quantities of material.  Natural product purifications often require the ability to work with such small sample sizes for both chemical and biological evaluations.


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