U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Liu, Ge

                                                         - *George*item
                                            Li, Robertitem
                                            Sonstegard, Taditem
                                            MATUKUMALLI, LAKSHAMI - GEORGE MASON UNIVERSITYitem
                                            Silva, Marcositem
                                            Van Tassell, Curtis

                                                         - *Curt*
  Submitted to: Animal Genetics
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 4/30/2008
                                    Publication  Date: 8/9/2008
                                    Citation: Liu, G., Li, R.W., Sonstegard, T.S., Matukumalli, L.K., Silva, M.V., Van Tassell, C.P. 2008. Characterization of a novel microdeletion polymorphism on BTA5 in cattle. Animal Genetics. 39(6):655-658.Interpretive Summary: Although genomic structural variation, including copy number variation (CNV) were associated with individual health and disease, the structure and population characteristics of these variants remain largely unexplored.  We present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple Olfactory Receptor genes. Using progressive cycles of PCR assays, we mapped the breakpoints of this microdeletion event into 1-12 kb genomic regions. We developed PCR-based genotyping assays, characterized 96 dairy cattle samples, and found that the frequency of the deletion allele is over 51%.  These results indicated that this microdeletion is an ancient event occurring in one of the earlier founders, and it has been stably inherited across the generations in the dairy cattle population. Annotation of CNVs in the cattle genome combined with sequence and population-based analyses provides an important resource that will help define the genetic basis of complex traits.
                                Technical Abstract: We present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple Olfactory Receptor genes. Using progressive cycles of PCR assays, we mapped the breakpoints of this microdeletion event into 1-12 kb genomic regions. We developed PCR-based genotyping assays, characterized 96 dairy cattle samples, and found that the frequency of the deletion allele is over 51%.  These results indicated that this microdeletion is an ancient event occurring in one of the earlier founders, and it has been stably inherited across the generations in the dairy cattle population.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov