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Title:   Author  item
                                            GYIMESI, ZOKLTAN S - LOUISVILLE, KYitem
                                            LAPPIN, MICHAEL - COLORADO STATE U FT COLLIitem
                                            Dubey, Jitender
  Submitted to: Journal of Zoo and Wildlife Medicine
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 3/1/2006
                                    Publication  Date: 10/1/2006
                                    Citation: Gyimesi, Z., Lappin, M.R., Dubey, J.P. 2006. Application of assays for the diagnosis of toxoplasmosis in a colony of woolly monkeys (Lagothrix lagotricha). Journal of Zoo and Wildlife Medicine. 37:276-280Interpretive Summary: Toxoplasma gondii is a single-celled parasite of all warm-blooded hosts worldwide. It causes mental retardation and loss of vision in children, and abortion in livestock. Cats are the main reservoir of T. gondii because they are the only hosts that can excrete the resistant stage (oocyst) of the parasite in the feces. Humans become infected by eating undercooked meat from infected animals and food and water contaminated with oocysts.Toxoplasmosis causes mortality in many species of animals in the zoos, especially primates.

Scientists at the Beltsville Agricultural Research Center  and  Lousville Zoological Garden , Kentucky report diagnosis of fatal toxoplasmosis in monkeys. The results will be of interest to biologists, parasitologists,  and veterinarians.
                                Technical Abstract: :  Toxoplasma gondii infection is a common cause of morbidity and mortality in New World primate species.  Clinical abnormalities associated with toxoplasmosis can be nonspecific making it difficult to make a definitive antemortem diagnosis and initiate appropriate treatment.  Toxoplasmosis in New World primates can have a rapid clinical course, which may lessen the diagnostic utility of antemortem tests.  However, while there are a variety of T. gondii serum antibody tests and T. gondii polymerase chain reaction (PCR) assays available that are not species specific, these assays have not been comparatively applied to New World primate cases.  Woolly monkeys (Lagothrix lagotricha), a species of New World primate, are highly susceptible to fatal toxoplasmosis.  Archived serum samples from 15 living and deceased woolly monkeys housed at the Louisville Zoological Garden were tested for T. gondii antibodies by a commercially available latex agglutination kit, a commercially available indirect hemagglutination kit, and the modified agglutination test.  In addition, aliquots of the sera were assayed for T. gondii DNA by use of a PCR assay.  Both woolly monkeys that died of disseminated toxoplasmosis were positive in all four assays suggesting that each could be used to aid in the diagnosis of toxoplasmosis in this species.  We suspect that these assays have applications to other species of New World primates.


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