<PAGE>   1
                                                                EXHIBIT 10.22

                               LEASE AGREEMENT

                                                        Lease Number: 100


<TABLE>
<CAPTION>
Lessor                                                            Lessee

<S>                                                               <C>
 National Leasing, Inc.                                            Simione Central, Inc.
----------------------------------------                          ----------------------------------------

 6600 Powers Ferry Road                                            6650 Powers Ferry Roasd
----------------------------------------                          ----------------------------------------

 Atlanta  Fulton  Georgia 30339                                    Atlanta  Fulton  Georgia 30339
----------------------------------------                          ----------------------------------------
City      County  State   Zip                                      City     County  State   Zip

 Gary Rasmussen  770.644-6517                                      Rhett Crook     770/859-1860
----------------------------------------                          ----------------------------------------
Contact Person      Phone                                          Contact Person      Phone

 4130 Whitney Ave./Hamden, CT 06518-0248                           550 Cochituate Rd./Framingham, MA 01701
-----------------------------------------------------------------------------------------------------------
Installation address if different from above
</TABLE>

                                Description: Make, Model & Serial Number
Quantity        (Use Exhibit A if Space Does Not Permit A Full Description Here)
-------------------------------------------------------------------------------
    8                9005680-0101/    Extensa 560CDT/  75
-------------------------------------------------------------------------------
    8                KTI-EXT550/8    KTI-EXT550/8
-------------------------------------------------------------------------------
    8                XJ1144/  XH1144S/R        14.4/ FAX
-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

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<TABLE>
<S>                                              <C>
A. Term of Agreement (Check One Plan)            D. Advance Payment $1,571.68
                                                                    ---------
     12 Month    X  36 Month   Other             Apply to  X  First Month (13 days)     First & Last Month(s)
 ---            ---         ---     -----                 ---                       ---
     24 Month       48 Month                               X  Security Deposit
 ---            ---                                       ---

B. Payment Due 1st of each Month                 E. Lease Commencement Date 3/18/96
                                $1,107.32                                   -------
                                ---------
C. Amount of each payment plus                   F. Lease End Purchase Option $4800.00
   sales, use, property, and other taxes                                      --------
</TABLE>

The undersigned Lessee has applied to Lessor for a lease of the above described
items ("Equipment") for commercial purposes.  For good and valuable
consideration, including processing this application, and intending to be
legally bound, LESSEE WILL NOT CANCEL THIS APPLICATION.  THIS IS A
NON-CANCELABLE LEASE FOR THE MINIMUM TERM INDICATED IN "A" ABOVE.  If Lessor
accepts, Lessee agrees to lease from Lessor, and Lessor agrees to lease to
Lessee, the Equipment, on all the terms hereof, including the Terms and
Conditions on the reverse side.  THIS WILL ACKNOWLEDGE THAT I HAVE READ AND
UNDERSTAND THIS LEASE AND HAVE RECEIVED A COPY OF THE LEASE.


/s/ Simione Central, Inc.               GUARANTY
-------------------------------------
Lessee Full Legal Name (Please Print)
                                        Undersigned hereby acknowledges that he
By X /s/ Gary W. Rasmussen              has read and understands this Lease and
-------------------------------------   guarantees performance of this Lease by
Authorized Signer                       Lessee and payment of all sums due
                                        hereunder in event of default, hereby
    Gary Rasmussen, CFO                 waiving any modification, amendment,
-------------------------------------   renewal or extension and notice thereof.
Authorized Signer's Printed Name Title
                                        Signature
                                                 ------------------------------
                                                     An Individual (No Title)

                                        Printed Name of Guarantor
  Accepted By Lessor                                             --------------
                                        Address
By /s/ Gary Bremer                                   --------------------------
-------------------------------------   City/State
   National Leasing, Inc.                            --------------------------
-------------------------------------   Business Phone
   Gary Bremer, President                            --------------------------
-------------------------------------

<PAGE>   2

                             TERMS AND CONDITIONS


1.   The term of this Lease Agreement (the "Lease") will commence on the lease
commencement date shown above and shall continue from the first day of the
following month for the number of consecutive months shown on the reverse side.
Lessor agrees to lease to Lessee and Lessee agrees to lease from Lessor the
personal property together with any attachment and accessories (collectively
the "Equipment") described on the reverse side hereof and on attached Exhibit A
(if any).  The Lease shall be subject to the terms and conditions set forth in
this Lease.  This Lease cannot be cancelled or terminated except as expressly
provided herein.

2.   Lessee shall pay monthly lease payments as provided on the reverse side
hereof, each being due in advance on the first day of each month.  The lease
payment for the month of commencement shall be prorated, as appropriate.  Time
is of the essence of payments due hereunder.  Should any lease payment not be
paid within five (5) days of when due, Lessee shall pay interest on the amount
owned from the due date until paid at the lesser of 1 1/2% per month or the
highest legal rate allowed under applicable law.  In addition, should any
payment not be made within five (5) days of when due, Lessee shall pay to
Lessor, for administrative services and not as a penalty, an amount equal to
the greater of $100.00 or   % of the past due amount.  Lessee agrees to pay
$20 to Lessor for any check returned by the bank for insufficient funds or any
other reason.  Upon termination of this Lease, Lessee shall immediately return
the Equipment to Lessor at the location designated by Lessor, at Lessee's
expense.  Lessee to pay all costs of packing, delivery, and dismantlement;
provided, however, that without acting as a renewal of the Lease or prejudicing
the rights of Lessor, Lessee shall pay monthly rental payments equal to 150%
of the then monthly rate until the Equipment is returned.  This is a net Lease
and all rentals are to be made by Lessee irrespective of any setoff,
counterclaim, recoupment or defense which Lessee may have against the supplier
of the Equipment or any other party.  Provided Lessee is not then in default,
Lessee may, at its option, renew this Lease on the same terms and conditions
for 12 month term(s) by providing Lessor with written notice of its intention
to so renew at least sixty (60) days prior to the end of the initial Lease term
or any renewal Lease term,  At the end of the term of this Lease, whether
after the initial period or after any renewal period, Lessee shall have the
option to purchase the Equipment which is the subject of this Lease for the
purchase option, if any, shown on the reverse side by giving Lessor written
notice of its intent to purchase at least sixty (60) days prior to the end of
the term of this Lease.  In the event that Lessee shall fail duly and promptly
any of its obligations under the provisions of this Lease to be performed by
it, Lessor may, at its option, immediately or at any time thereafter perform
the same for the account of Lessee without thereby waiving such default.  Any
amount paid or expense or liability incurred by Lessor in such performance,
together with interest at the rate specified in paragraph two hereof, until
paid by Lessee to Lessor, shall be payable by Lessee upon demand as additional
rent for the Equipment.  The parties agree that the monthly lease rate set
forth on the reverse side hereof is based on a mutually determined estimated
cost of all Equipment and that the actual lease rate may, at the option of the
Lessor, be adjusted upward or downward if the actual cost exceeds or is less
than the estimate.

3.   Lessee shall pay when due all sales, use, personal property and other
taxes and filing fees related to the Equipment, excluding only Lessor's income
taxes.  This is a net Lease.

4.   Lessee acknowledges that the Equipment is of a size, design, capacity,
description, manufacturer and supplier selected by the Lessee and will be
maintained solely by Lessee or its contractors, but that the Equipment is
and shall remain the sole and exclusive property of Lessor.  LESSOR MAKES NO
WARRANTIES OR REPRESENTATIONS, EXPRESS OR IMPLIED, AS TO VALUE, DESIGN,
CONDITION, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF THE
EQUIPMENT.  LESSOR WILL NOT BE LIABLE FOR ANY LOSS, COSTS OR DAMAGE TO LESSEE
OR OTHERS ARISING FROM DEFECTS, NEGLIGENCE, DELAYS, FAILURE OF DELIVERY, OR OF
NON-PERFORMANCE OF THE EQUIPMENT, AND THERE WILL BE NO REDUCTIONS OF PAYMENTS
BY LESSEE FOR ANY REASON, INCLUDING BUT NOT LIMITED TO, ANY DEFENSE, SET OFF OR
ANY CLAIM ARISING OUT OF OR RELATED TO ANY DEFECTS OR DAMAGES TO THE EQUIPMENT
FROM ANY CAUSE WHATSOEVER, IT BEING THE INTENTION OF THE PARTIES THAT LEASE
PAYMENTS SHALL BE PAID IN ALL EVENTS.

5.   Lessee shall keep the Equipment at the above Lessee's address or at the
locations shown on Exhibit A in Lessee's sole and absolute control, or such
other location consented to in advance in writing by Lessor, free and clear of
any liens, levies and encumbrances, other than in favor of any financial
institutions which from time to time provide financing to Lessor.  Lessee shall
keep and maintain the Equipment in a careful, proper manner, in good order,
condition and appearance, reasonable wear and tear excepted and shall permit
the Equipment to be used only by Lessee or its employees.  Lessee shall not
modify the Equipment, unless in accordance with a recommendation by the
manufacturer, without the prior written consent of Lessor.  LESSEE SHALL NOT
ASSIGN OR IN ANY WAY DISPOSE OF ALL OR ANY PART OF ITS RIGHTS OR OBLIGATIONS
UNDER THIS LEASE OR ENTER INTO ANY SUBLEASE OF ALL OR ANY PART OF THE EQUIPMENT
WITHOUT THE PRIOR WRITTEN CONSENT OF LESSOR.  Lessor hereby assigns and
transfers to Lessee for the term of this Lease and any buy-out all warranties,
updates, and rights, if any, made by the manufacturer or supplier of the
Equipment.

6.   Lessee hereby assumes all risk of loss, damage or destruction of the
Equipment from any cause whatsoever; no loss, damage or destruction of or to
the Equipment or any part thereof shall impair or abate any obligation of
Lessee under the Lease.  Lessee shall at its own expense obtain and maintain on
or with respect to the Equipment insurance against fire and other perils
customarily covered by owners of like property, in a reasonable amount not less
than the greater of the full replacement value of the Equipment or the
remaining payments under the Lease, and shall name Lessor and/or Lessee's
assignee as additional insureds on such insurance policies and provide a copy
of same to Lessor or its assignee.  Lessor reserves the right to select the
insurer and/or deductible for any such policies.  Lessee shall promptly notify
Lessor of any damage to or loss of the Equipment or any part thereof.

7.   Lessee hereby indemnifies and agrees to save Lessor harmless from any and
all liability and expense arising out of the ordering, ownership, use,
condition, or operation of each item of Equipment during the term of this
Lease, including liability for death or injury to persons, damage to property,
whether or not caused by removal of the Equipment, strict liability under the
laws or judicial decisions of any state or the United States, and legal
expenses in defending any claim brought to enforce any such liability or
expense.  Lessee's obligations under this paragraph shall survive termination
of the Lease Agreement.

8.   COMPUTER SOFTWARE. Notwithstanding any other terms and conditions of the
Lease Agreement, in the event that this Lease includes software equipment, then
Lessee agrees that as to such software only: (a) Lessor has not had, does not a
have, nor shall have, any title to such software, (b) Lessee has executed
or will execute a separate software license agreement and Lessor is not  party
to, nor has any responsibilities whatsoever, e.g., fees or other payments, in
regards to such license agreement, (c) Lessee has selected such software and as
per Lease paragraph 4, LESSOR MAKES ABSOLUTELY NO WARRANTY OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE IN REGARDS TO SUCH SOFTWARE AND
HAS ABSOLUTELY NO RESPONSIBILITY FOR THE FUNCTION OR DEFECTIVE NATURE OF SUCH
SOFTWARE. (d) Lessee shall indemnify and hold harmless Lessor from any loss
(including, without limitation, legal fees and costs) or liability incurred by
Lessor under this Lease Agreement or otherwise in any way related to or
connected with the abovesaid license or related agreement(s), and in the event
Lessor incurs or is threatened by such liability, then upon request of Lessor,
Lessee shall promptly accelerate all Lease payments due under the entire Lease
contract, and (a) LESSEE'S LEASE PAYMENTS AND OTHER OBLIGATIONS UNDER THIS
LEASE AGREEMENT SHALL IN NO WAY BE DIMINISHED ON ACCOUNT OF OR IN ANY WAY
RELATED TO THE ABOVESAID SOFTWARE LICENSE AGREEMENT.  None of the foregoing
terms of this paragraph are intended to diminish the Lessee's obligations under
the other terms and conditions of this Lease Agreement.

9.   Lessee's rights and obligations under this Lease are personal and
non-assignable, absent the express written consent of Lessor.  Lessee will
affix on the Equipment appropriate plates or labels identifying the Equipment
as the property of Lessor, maintain the identification at all times, and
replace it in kind if it becomes defaced or destroyed.  Should the Equipment be
located in premises leased by the Lessee, Lessee shall obtain upon Lessor's
request a form of landlord's waiver acceptable to Lessor which form of waiver
shall include the following provisions, and such other provisions as may be
reasonably required by lessor; landlord acknowledges that any lien held by
landlord with respect to Equipment, statutory or otherwise, is subordinated to
the Lease; landlord agrees that Lessor or its successors or assigns is the owner
of all the Equipment, whether attached to the leased premises or not and that
the Lessee and Lessor or their successors and assigns have the right to remove
the Equipment from the leased premises at any time without hindrance or let on
the part of landlord.  Lessee shall not assign, transfer, pledge or mortgage
this Lease or any part of the Equipment, nor allow a lien of other encumbrance
or attachment of any kind to be placed on such Equipment.  Lessor may sell,
assign, transfer, pledge or mortgage as security, its rights under this Lease
and its ownership in the Equipment.  Lessor will have the right to enter
Lessee's premises at reasonable times in the presence of Lessee to inspect the
Equipment.  Lessee authorizes Lessor, its successors, assigns, and lenders to
Lessor, to file a copy of this Lease as a financing statement for the Equipment
and will execute other documents for filing or recording as requested, and pay
the fees therefore.  Further, Lessee authorizes Lessor to sign on behalf of
Lessee any U.C.C. or financing statement or related documents deemed necessary
or advisable by Lessor its assigns.  The Equipment is, and at all times will
remain personal property, even if affixed to any land or building.  Lessee
authorizes Lessor to insert in this Lease, and in any filings, the serial
number(s) of the Equipment.

10.  Should Lessee fail to pay any rental or other sum due hereunder or breach
any covenant, warranty or representation hereunder or if any execution or
other writ of process shall be issued in any action or proceeding against
Lessee whereby the Equipment may be taken or restrained or a proceeding in
bankruptcy, receivership or insolvency shall be instituted against Lessee and
continue undismissed for a period of thirty (30) days, or if Lessee shall enter
into any agreement or composition with its creditors, Lessor may, without
further notice, take the following action: (a) declare due, sue for, and
receive from the Lessee the sum of all rents and other amounts due and owing
under this Lease plus the sum of the rents and other amounts to become payable
during the balance of the term of this Lease (reduced to present value at an
assumed rate of six (6) percent) plus the reversionary value of the Equipment
as reasonably determined by Lessor.  Upon such recovery the equipment shall
become the property of the Lessee; (b) retake possession of any and all
Equipment without any court order or other process of law.  For such purpose,
the Lessor may enter upon any premises where such Equipment is located and
remove same therefrom without being liable to any suit, action, or other
proceeding by the Lessee.  The Lessor may, at its option, relet the Equipment.
The Lessee shall be liable for arrears of rent, if any, the expense of retaking
possession, and the removal of the Equipment, court costs, in addition to the
balance of the rentals provided for herein, or in any renewal hereof, less the
net proceeds of the re-letting of the Equipment, if any, after deducting all
costs of taking, storage, repair and sale, and reasonable attorneys fees.  THE
LESSEE WAIVES ANY AND ALL RIGHTS TO NOTICE AND TO A JUDICIAL HEARING WITH
RESPECT TO THE REPOSSESSION OF THE EQUIPMENT BY THE LESSOR; (c) Terminate this
Lease as to any or all Equipment; (d) Terminate any other Lease between the
Lessor and the Lessee; or (e) Pursue any other remedy at law or in equity.  The
rights granted to the Lessor under paragraph (10) shall be cumulative and
action on one shall not be deemed to constitute an election or waiver of any
other right to which the Lessor may be entitled.  The Lessee waives trial by
jury in any action or proceeding arising hereunder.  Lessee shall pay all costs
of enforcing Lessor's rights hereunder, including collection and attorney's
fees equal to 15% of all sums owed Lessor under this Lease.  No express or
implied waiver by Lessor of any default shall constitute a waiver of any other
default by Lessor or a waiver of any of Lessor's rights.

11.  This Lease shall inure to the benefit of and be binding upon the Lessee's
successors and permitted assigns, however, no assignment shall relieve Lessee
of its liabilities and obligations hereunder.  This Lease shall also inure to
the benefit of and be binding upon Lessor's successors and assigns.

12.  Notices to Lessor shall be mailed Certified Mail Return Receipt Requested,
in care of the President to the address on the reverse side and to the Lessee
at the Lessee's address by the same method, unless changed by written notice
given to the other party.  Notices shall be deemed received on the date when
mailed.

13.  Lessor may apply any advance payment to any overdue sum at any time, and
on termination of this Lease and fulfillment of all the terms and conditions
thereof by Lessee.  Lessor will return the unapplied balance thereof to the
Lessee.

14.  This Lease and the rights and remedies of the parties shall be
interpreted, construed and enforced in accordance with the laws of the State of
Georgia, including all matters of construction, validity and performance.  This
Lease was executed in the State of Georgia and as such, Lessee and Lessor
agree to submit to the jurisdiction of the state and/or federal courts thereof.
The parties expressly waive any right to a trial by jury.

15.  This Lease constitutes the entire understanding or agreement between the
parties and may not be amended except in writing signed by the parties to be
bound.