**EXHIBIT      10.25**

**LEASE      AMENDMENT NO. 4**

**Whitesell      Enterprises**
**American      Bio Medica Corporation**

| 1. | The                term of the Lease for Units 3 and 4 at 603 Heron Drive, Bridgeport,                New                Jersey shall be extended for a period of five (5) years, commencing                November 1, 2006 and terminating October 31,2011. |
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| 2. | The                base rental rate for this extension period for Units 3 and 4 shall                be                $5.95 per square foot net, $54,543.65 yearly, $4,545.30 monthly. |
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| 3. | Tenant                has agreed to take additional space in Unit 6 at 603 Heron Drive,                Bridgeport, New Jersey consisting of approximately 5,239 square feet.                Tenant's pro rata share for Unit 6 is 12.11 %. |
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| 4. | The                term of the Lease for Unit 6 shall be for a period of five (5) years                commencing on or about November 1,2006 and terminating October 31,                2011. |
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| 5. | The                base rental rate for Unit 6 shall be $5.95 per square foot net, $31,172.05                yearly, $2,597.67 monthly. |
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| 6. | Landlord                at Landlord's cost shall provide the following scope of work to Unit                6                only. |
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|  | 1. | Build                office area as shown on attached space plan. |
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|  | 2. | Build                a wall separating the warehouse from the loading area. |
|--|----|-----------------------------------------------------------------------------|

|  | 3. | Air                condition the warehouse. |
|--|----|---------------------------------------------|

| 7. | Provided                Tenant is not then in default under this Lease, Landlord offers to                Tenant                the "Right of First Offer" to lease the property known as Unit 5                at 603                Heron Drive, Bridgeport, New Jersey consisting of 6,449 square feet,                upon                the expiration of the existing Tenant's lease on May 31, 2009. The                term                shall be for two (2) years, five (5) months commencing June 1, 2009                and                terminating October 31, 2011. Tenant to Lease unit in "As Is Condition".                All systems in working order and unit to be clean. The base rental                rate                shall be $4.50 per square foot net.  |
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**LANDLORD:**
**WHITESELL      ENTERPRISES**

|   |                                              |   |   |   |
|--------|---------------------------------------------------|--------|--------|--------|
| By:    | /s/              Thomas J. Heitzman               |   |   |        |
|   | Thomas              J. Heitzman, Authorized Agent |   |   |        |

**TENANT:**
**AMERICAN      BIO MEDICA CORPORATION**

|   |                                           |   |   |   |
|--------|------------------------------------------------|--------|--------|--------|
| By:    | /s/              Stan Cipkowski / Keith Palmer |   |   |        |
|   | Stan              Cipkowski / Keith Palmer     |   |   |        |

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