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Title:   Author  item
                                            CHUN, HYE-KYUNG - NIAST RDA SUWON KOREAitem
                                            LEE, SUNG-HYEON - NIAST RDA SUWON KOREAitem
                                            CHO, SO-YOUNG - NIAST RDA SUWON KOREAitem
                                            CHUNG, HYUN-JIN - NIAST RDA SUWON KOREAitem
                                            PARK, HONG-JU - NIAST RDA SUWON KOREAitem
                                            CHO, SOO-MUK - NIAST RDA SUWON KOREAitem
                                            LEE, YOUNG-MIN - NIAST RDA SUWON KOREAitem
                                            Lillehoj, Hyun
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/6/2005
                                    Publication  Date: 9/10/2005
                                    Citation: Chun, H., Lee, S., Cho, S., Chung, H., Park, H., Cho, S., Lee, Y., Lillehoj, H.S. 2005. Effects of dietary phytic acid on the serum lipid levels in aged mice.Proceedings of International Symposium on Triglycerides, p. 21.Interpretive Summary:
                                Technical Abstract: Aging is a multi-factorial phenomenon. There are several clinical
conditions directly related to the lipid metabolism that induces
hypertriglycemia, hypercholesterolemia and cardiovascular disease
during aging. There is a large body of evidence showing that triglyceride, cholesterol and LDL-cholesterol are among the major risk factors for cardiovascular disease, while HDL-cholesterol level is inversely correlated with such a risk. Attention has been focused on possible intervention strategies to control the levels of serum lipid, such as triglyceride, total cholesterol, LDL- or HDL-cholesterol. Phytic acid is a plant component which exists in most grains and legumes, the main source of the calorie intake for the old, and much research has been done on the antioxidant and antinutrient effects of phytic acid in the growing animal model. But its effect on the lipid profiles in the aged model has not been evaluated yet. The study was carried out to investigate the effect of phytic acid on the lipid levels in the serum of aged mice. Forty aged ICR male mice were fed with purified diets supplemented with 0 (PO), 0.5 (P5), 1.0 (PIO), and 1.5 % (PIS) sodium phytate for 12 weeks. Diet intake, body and organ weights, and contents of serum and fecal lipid profiles were measured. There were no significant differences in diet intake, body weight, organ weight and serum total cholesterol levels among experimental groups. The concentrations of the serum triglyceride and LDL-cholesterol were lower in the groups fed phytate diets than the
POgroup. Serum HDL-cholesterollevels of the groups fed phytate diets were higher than the POgroup. The contents of fecal total lipid and total cholesterol were higher in the PIO and the PIS groups. These results suggested that phytic acid affect the serum lipid levels in aged mice by increasing their fecal lipid levels.


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