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Title:   Author  item
                                            Swaggerty, Christina

                                                         - *Christi*item
                                            PEVZNER, I - COBB-VANTRESS, INCitem
                                            Kogut, Michael

                                                         - *Mike*
  Submitted to: Keystone Symposia
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 10/6/2006
                                    Publication  Date: 1/5/2007
                                    Citation: Swaggerty, C.L., Pevzner, I.Y., Kogut, M.H. 2007. Differential JAK response in polymorphonuclear cells from a non-mammalian species following exposure to Salmonella enteritidis [abstract]. In: Proceedings of Keystone Symposia on Molecular and Cellular Biology - Jaks, Stats and Immunity, January 5-10, 2007, Steamboat Springs, Colorado. p. 66.Interpretive Summary:
                                Technical Abstract: The Janus family of tyrosine kinases (JAKs) are non-receptor tyrosine kinases which associate with cytokine receptors and are activated by ligand binding and subsequently auto-phosphorylate.  JAK1 is involved in numerous signal transduction pathways, specifically interleukin (IL)-2, IL-6 and interferon (IFN) alpha, beta, and gamma receptors.  We have extensively characterized the innate immune response of two parental lines (A and B) of chickens and shown that heterophils from B chickens have high mRNA expression levels of IFN-alpha following agonist stimulation while expression levels in A were unchanged from controls.  Knowing there is a differential IFN-alpha response between the lines, we wanted to quantitate the levels of JAK in heterophils from A and B chickens.  Heterophils were isolated from 4-day-old chickens, stimulated with a phagocytic agonist, Salmonella enteritidis (SE), and JAK levels quantitated.  Total JAK levels in control heterophils were higher in B compared to A.  Further, the differences between A and B were maintained following SE-phagocytosis.  These data provide initial information that differences between the IFN-' mRNA expression of line A and B chickens is likely due, in part, to a differential signaling pathway(s).


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