U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Kapczynski, Darrell
  Submitted to: Avian Diseases
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 12/9/2003
                                    Publication  Date: 6/20/2004
                                    Citation: Kapczynski, D.R. 2004. Development of A Virosome Vaccine For Protection In Turkeys Against Avian Metapneumovirus Subtype C. Avian Diseases v.48, p.332-343. 2004.Interpretive Summary: Avian metapneumovirus (aMPV) is responsible for a highly infectious respiratory disease of turkeys.  Virosome vaccines have been shown to induce specific protection against many different viruses. In an effort to protect birds from this disease, production of a novel aMPV virosome vaccine was developed and tested in turkeys.  The results indicate vaccination with virosomes can increase protection from clinical signs of disease and decrease virus titers in respiratory tissue.
                                Technical Abstract: An avian metapneumovirus (aMPV) virosome vaccine was prepared and tested for protection of turkeys by aMPV challenge.  The vaccine was produced using a detergent-based (Triton X-100) extraction of aMPV subtype C  followed by detergent removal with SM2 Bio-Beads.  Western blot and virus-neutralization analysis confirmed that the aMPV virosomes contained both the fusion (F) and attachment (G) glycoproteins.  SPF turkeys were immunized either intranasally (IN) or intramuscularly (IM) with 2 doses of the aMPV virosome vaccine.  Vaccination decreased clinical signs of disease following virulent challenge and  IN vaccination was superior to IM vaccination in reducing clinical signs. Decreases in viral load in the respiratory tract were observed in turkeys receiving IN vaccination with aMPV virosomes compared to unvaccinated poults. Increased virus-neutralizing antibody levels against aMPV were observed in birds vaccinated with virosomes. These results demonstrate that immunization of turkeys with aMPV virosomes can be an effective strategy for control of disease.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov