Fifth Amendment to Lease Agreement



 Exhibit 10.1 
 FIFTH AMENDMENT 
 THIS FIFTH AMENDMENT (the “Amendment”) is made
and entered into as of July 6, 2011, by and between 4350 LA JOLLA VILLAGE LLC, a Delaware limited liability company, (“Landlord”) and MEDICINOVA, INC., a Delaware corporation (“Tenant”). 

RECITALS 
  

	A.	 Landlord and Tenant are parties to that certain lease dated January 28, 2004, which lease has been previously amended by a First Amendment dated
August 10, 2004, a Second Amendment dated March 21, 2005, a Third Amendment dated January 31, 2008 and Fourth Amendment dated October 3, 2008 (collectively, the “Lease”). Pursuant to the Lease, Landlord has leased to
Tenant space currently containing approximately 12,699 rentable square feet described as Suite Nos. 900, 950 (“Suite 950”), 960, and 970 (collectively, the “Original Premises”), on the 9th floor of the building located at 4350 La Jolla Village Drive, San
Diego, California (the “Building”). 


  

	B.	The Lease by its terms shall expire on August 31, 2011 (“Third Prior Termination Date”), and the parties desire to extend the Term of the Lease with
respect to Suite 950 only consisting of 5,089 rentable square feet as depicted in Exhibit A hereof, all on the following terms and conditions. 

 NOW, THEREFORE, in consideration of the above recitals which by this reference are incorporated herein, the mutual covenants and conditions contained herein and other valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant agree as follows: 
  

	I.	Extension. The Term of the Lease with respect to Suite 950 only is hereby extended and shall expire on May 31, 2012 (“Fourth Extended
Termination Date”), unless sooner terminated in accordance with the terms of the Lease. That portion of the Term commencing the day immediately following the Third Prior Termination Date (“Fourth Extension Date”) and ending on the
Fourth Extended Termination Date shall be referred to herein as the “ Fourth Extended Term”. From and after the Fourth Extension Date, the “Premises” as defined in the Lease shall mean Suite 950 consisting of 5,089 rentable
square feet. 

  

	II.	Base Rent. As of the Fourth Extension Date, the schedule of Base Rent payable with respect to the Premises during the Fourth Extended Term is the
following: 

  

									
	 Months of Term or Period
	  	Monthly Rate Per
Square
Foot	 	  	Monthly Base Rent	 
	 9/1/11-5/31/12
	  	$	2.45	  	  	$	12,468.00	  

 All such Base Rent shall be payable by Tenant in accordance with the terms of the Lease. 

 

	III.	Expenses and Taxes. For the period commencing on the Fourth Extension Date and ending on the Fourth Extended Termination Date, Tenant shall be obligated
to pay Tenant’s Pro Rata Share of Expenses and Taxes accruing in connection with the Premises in accordance with the terms of the Lease. In addition, Tenant’s Pro Rata Share for the Premises commencing on the Fourth Extension Date and
ending on the Fourth Extended Termination Date shall be 2.63%. 

  

	IV.	Security Deposit. Provided Tenant is not in default, effective as of the Substitution Effective Fourth Extension Date, the Security Deposit held by
Landlord as provided under Section 6 of the Lease, as amended, as security for payment of Rent and the performance of the other terms and conditions of the Lease by Tenant shall be reduced from $89,664.00 to $44,832.00. Provided Tenant
is not in default, Landlord shall return to Tenant the excess Security Deposit in the amount of $44,832.00 within a reasonable time after the Fourth Extension Date. 


 

	V.	Improvements to Premises. 

  

	 	A.	Condition of Premises. Tenant is in possession of the Premises and accepts the same “as is” without any agreements, representations, understandings or
obligations on the part of Landlord to perform any alterations, repairs or improvements, except as may be expressly provided otherwise in this Amendment. 

  

	 	B.	Tenant Improvements. Landlord shall cause its contractor to demise the reception are in the Premises pursuant to the demising plan prepared by Gensler dated
January 26, 2011 (“Tenant Improvements”). All such improvements shall be set forth at one time by Tenant as part of a single plan, it being understood that Landlord shall not be required to undertake multiple jobs. All materials and
finishes utilized in completing the Tenant Improvements shall be Landlord’s building standard. Should Landlord submit any matter to Tenant for approval, Tenant shall approve or reasonably disapprove same (with reasons specified) within 3
business days. 

 It is understood that the Tenant Improvements shall be done during Tenant’s occupancy of the
Premises. In this regard, Tenant agrees to assume any risk of injury, loss or damage which may result and that no rental abatement shall result while the Tenant 

  
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Improvements are completed in the Premises. Tenant further agrees that it shall be solely responsible for relocating its office equipment, furniture and furnishings in the Premises to accommodate
such improvement work. 
  

	VI.	Parking. Notwithstanding any contrary provision in Exhibit G to the Lease, “Parking Agreement,” as amended, effective as of the Fourth Extension
Date, Landlord shall lease to Tenant, and Tenant shall lease from Landlord, 17 unreserved parking spaces in the Parking Facility at the rate of $55.00 per stall per month through the Fourth Extended Term. 


 

	VII.	SDN List. Tenant hereby represents and warrants that neither Tenant nor any officer, director, employee, partner, member or other principal of Tenant
(collectively, “Tenant Parties”) is listed as a Specially Designated National and Blocked Person (“SDN”) on the list of such persons and entities issued by the U.S. Treasury Office of Foreign Assets Control (OFAC). In the event
Tenant or any Tenant Party is or becomes listed as an SDN, Tenant shall be deemed in breach of this Lease and Landlord shall have the right to terminate the Lease immediately upon written notice to Tenant. 


 

	VIII.	GENERAL. 

  

	 	A.	Effect of Amendments. The Lease shall remain in full force and effect except to the extent that it is modified by this Amendment. 


 

	 	B.	Entire Agreement. This Amendment embodies the entire understanding between Landlord and Tenant and can be changed only by a writing signed by Landlord and
Tenant. There have been no additional oral or written representations or agreements. Under no circumstances shall Tenant be entitled to any rent abatement, improvement allowance, leasehold improvements, or any similar economic incentives that may
have been provided Tenant in connection with entering into the Lease, unless specifically set forth in this Amendment. 

  

	 	C.	Counterparts. If this Amendment is executed in counterparts, each is hereby declared to be an original; all, however, shall constitute but one and the same
amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation. 

  


	 	D.	Defined Terms. All words commencing with initial capital letters in this Amendment and defined in the Lease shall have the same meaning in this Amendment as in
the Lease, unless they are otherwise defined in this Amendment. 

  

	 	E.	Authority. If Tenant is a corporation, limited liability company or partnership, or is comprised of any of them, each individual executing this Amendment for the
corporation, limited liability company or partnership represents that he or she is duly authorized to execute and deliver this Amendment on behalf of such entity and that this Amendment is binding upon such entity in accordance with its terms.


  

	 	F.	Attorneys’ Fees. The provisions of the Lease respecting payment of attorneys’ fees shall also apply to this Amendment. 


 

	 	G.	Execution of Amendment. Submission of this Amendment by Landlord is not an offer to enter into this Amendment but rather is a solicitation for such an offer by
Tenant. Landlord shall not be bound by this Amendment until Landlord has executed and delivered the same to Tenant. 

  

	 	H.	Nondisclosure of Terms. Except (i) as required by law; (ii) in connection with a dispute or litigation hereunder; (iii) as required by subpoena;
or (iv) pursuant to regulations and statutes for publicly traded entities, Tenant agrees that neither Tenant nor its agents or any other parties acting on behalf of Tenant shall disclose any matters set forth in this Amendment or disseminate or
distribute any information concerning the terms, details or conditions hereof to any person, firm or entity without obtaining the express written consent of Landlord, which consent will not be unreasonably withheld, conditioned or delayed. Landlord
acknowledges that Tenant is required to file this Amendment with the Securities Exchange Commission. 


[SIGNATURES ON FOLLOWING PAGE] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Amendment as of the
day and year first above written. 
  

									
	LANDLORD:	 		 	TENANT:
			
	 4350 LA JOLLA VILLAGE LLC,
 a Delaware limited liability company
	 		 	 MEDICINOVA, INC.,
 a Delaware corporation

					
	By:	 	/s/ Steven M. Case	 		 	By:	 	/s/ Yuichi Iwaki
		 	Steven M. Case	 		 	Printed Name:	 	Yuichi Iwaki
		 	Executive Vice President, Leasing	 		 	Title:	 	President & CEO
					
	By:	 	/s/ Michael T. Bennett	 		 	By:	 	/s/ Michael Coffee
		 	Michael T. Bennett	 		 	Printed Name:	 	Michael Coffee
		 	Senior Vice President, Operations	 		 	Title:	 	Interim CFO, Secretary


  
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