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Title:   Author  item
                                            CHI, ZHI-HONG - CHINA MEDICAL UNIVERSITYitem
                                            WANG, XIN - CHINA MEDICAL UNIVERSITYitem
                                            WANG, ZHAN-YOU - CHINA MEDICAL UNIVERSITYitem
                                            GAO, HUI-LING - CHINA MEDICAL UNIVERSITYitem
                                            DAHLSTROM, ANNICA - GOTEBORG UNIV. SWEDENitem
                                            Huang, Liping
  Submitted to: NeuroReport 
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 8/9/2006
                                    Publication  Date: 11/27/2006
                                    Citation: Chi, Z., Wang, X., Wang, Z., Gao, H., Dahlstrom, A., Huang, L. 2006. Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. NeuroReport. 2006. Vol.17:1807-1811. Interpretive Summary: The cellular localization of zinc transporter 7 protein in the mouse choroid plexus was examined in this study. Zinc transporter 7 immunoreactive cells were detected in the third, lateral, and fourth ventricles of CD-1mouse brain. Distinct zinc transporter 7 immunoreactivity was concentrated in the perinuclear regions of the positive cells. The results from zinc autometallography showed that zinc-positive grains were also predominantly located in the perinuclear areas. Ultrastructural localization showed thatzinc transporter 7 immunostaining was predominantly present in the membrane and cisternae of the cis-Golgi networks and some vesicle compartments. The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus.
                                Technical Abstract: The cellular localization of zinc transporter 7 protein in the mouse choroid plexus, an area on the ventricles of the brain where cerebrospinal fluid (CSF) is produced, was examined in this study. Zinc transporter 7 expressing cells were detected in the third, lateral, and fourth ventricles of the mouse brain. The zinc transporter 7 protein was primarily detected in the perinuclear regions of the cell. The results from zinc autometallography showed that zinc-positive grains were also predominantly located in the perinuclear areas of the cell. Ultrastructural localization showed that the zinc transporter 7 protein was predominantly present in the membrane and cisternae (flattened membrane disks which makes up the Golgi apparatus) of the cis-Golgi networks (the side facing the endoplasmic reticulum) and some vesicle compartments. The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus.


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