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Title:   Author  item
                                            Jung, Yong Sooitem
                                            Anderson, Robinitem
                                            Edrington, Thomasitem
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Callaway, Todditem
                                            Byrd Ii, James

                                                         - *Allen*item
                                            MCREYNOLDS, JACK - TX A&M UNIVERSITYitem
                                            Harvey, Rogeritem
                                            Nisbet, David
  Submitted to: Western Section of Animal Science Proceedings
                                    Publication Type: Proceedings
                                    Publication Acceptance Date: 3/26/2003
                                    Publication  Date: 6/22/2003
                                    Citation: Jung, Y., Anderson, R.C., Edrington, T.S., Genovese, K.J., Callaway, T.R., Byrd II, J.A., McReynolds, J., Harvey, R.B., Nisbet, D.J. 2003. Effect of 2-nitropropanol on Salmonella typhimurium concentrations in the ceca of broiler chicks. Proceedings of Western Section American Society of Animal Science. 54:107-107.Interpretive Summary:
                                Technical Abstract: The bactericidal effect of 2-nitropropanol (2NPOH) was determined in vivo.  Chicks were orally challenged with approximately 10**6 CFU per ml of Salmonella Typhimurium at 6 days of age.  Chicks were then divided into three groups: control (0 mg 2NPOH/bird), 0.5X (6.5 mg 2NPOH/bird), and 1X (13 mg 2NPOH/bird) and treatments were administered orally one day post challenge.  Cecal contents collected at necropsy 24 and 48 h after treatment were subjected to bacterial and volatile fatty acid analysis.  Mean +/- SD populations of Salmonella were reduced (P < 0.05) in the group administered 1X (13 mg/bird) treatment at both the 24 and 48 h samplings compared to untreated control (2.58 +/- 2.10 versus 4.64 +/- 1.79 and 2.88 +/- 2.78 versus 5.03 +/- 2.42; 24 and 48 h, respectively).  Analysis of volatile fatty acid (VFA) accumulation in cecal contents showed that concentrations of propionate, but not acetate or butyrate, were reduced (P < 0.05) by 1X treatment.  Mean concentrations of total VFA within 2NPOH treated groups were not significantly different at 24 and 48 h.  Results obtained in this study suggest there is potential applicability of 2NPOH as a bactericidal supplement against Salmonella in poultry.


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