U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Immunity and Disease Prevention Research: Davis, CA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Laboratories
                        Stephensen Group
                                    Kable Group
                                    Lemay GroupSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Immunity and Disease Prevention Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            MAGVANUA, MARK - UCD, MOLECULAR & CELL BIOitem
                                            DAWSON, KEVIN - UCD, GENOME LAUNCH CNT.item
                                            Huang, Lipingitem
                                            MALYJ, WASYL - UCD, GENOME LAUNCH CNT.item
                                            GREGG, JEFF - UCDMC, MOLECULAR PATH.item
                                            GALVEZ, ALFREDO - UCD, MOLECULAR & CELL BIOitem
                                            RODRIGUEZ, RAYMOND - UC DAVIS, MED. CNT.
  Submitted to: Book Chapter
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/15/2006
                                    Publication  Date: 5/1/2006
                                    Citation: Magvanua, M.J., Dawson, K., Huang, L., Malyj, W., Gregg, J., Galvez, A.F., Rodriguez, R.L. 2006. NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS. John Wiley & Sons, Inc. Chapter 11:255-276.Interpretive Summary: Numerous studies have identified certain components of soybean as having anti-cancer properties. Lunasin, a small soybean protein, has been shown to prevent cancer from occurring in cultured cells and animals. It was shown that lunasin was able to bind to histone, proteins which wrap genetic material of the cell, and change their shapes which result in the expression of cancer fighting genes in the body. In this study, we used microarray technology to study gene expression profiles of normal and cancer- prone prostate cells treated with lunasin. We found that many genes which control cell proliferation, inhibit tumor growth, and promote cell death were positively affected by lunasin. We propose that lunasin prevents cancer by up-regulating the expression of genes that prevent the onset of the disease.
                                Technical Abstract: Numerous studies have identified certain components of soybean as having anticancer properties. Lunasin, a unique 43-amino acid soybean peptide, has been shown to suppress carcinogenesis in mammalian cells and mouse models. It has been hypothesized that lunasin modulates changes in chromatin organization by modifying histone tails, thereby, resulting in the expression of chemopreventive genes. In this report, microarray analysis was used to reveal a novel property of lunasin - its ability to up-regulate tumor suppressor and other chemopreventive genes in prostate epithelial cells. The effects of exogenous lunasin on the comprehensive gene expression profiles revealed that a total of 123 genes had a greater than twofold change in expression in the lunasin-treated cells as compared to the mock-treated cells.  Of these genes, 121 genes were up-regulated in normal RWPE-1 cells and only two genes were up-regulated in malignant RWPE-2 epithelial cells. No genes were down-regulated in either cell line treated with lunasin. The genes up-regulated in RWPE-1 cells include those involved in tumor suppression, apoptosis and the control of cell division. These results shed new light on lunasin's previously observed chemopreventive properties. 
We propose that lunasin prevents cancer in vitro and in small animal models by up-regulating the expression of genes that prevent the onset of the disease.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov