U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Healthy Processed Foods Research: Albany, CA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Pacific West Area Albany, California Western Regional Research Center Healthy Processed Foods Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications
- Rebecca Milczarek *(Scopus)*
- Yuzhu Zhang *(PubMed)*

Title:   Author  item
                                            Hong, Yun Jeongitem
                                            TUROWSKI, MACIEJ - DOW CHEMICAL CO., MIitem
                                            LYNCH, STEPHANIE - DOW CHEMICAL CO., MIitem
                                            SHAO, QIMING - SCIOS, FREMONT, CAitem
                                            CHEN, MINXIA - XIAN MED. UNIV., CHINAitem
                                            HU, WEI-SHOU - UNIV. OF MINNESOTA, MNitem
                                            Yokoyama, Wallace

                                                         - *Wally*
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/26/2006
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Male Syrian hamsters fed 35% fat calorie diets become insulin resistant within a few weeks.  Compared to a low-fat diet, the glucose infusion rate decreases by about 50% under conditions of the hyperinsulinemic euglycemic clamp methods.  Longer term fat feeding results in obesity, hypertension, abdominal fat gain, increased plasma lipids, increased liver fat and other symptoms common to dietary metabolic diseases.  The replacement of 5-8% insoluble fiber by soluble cellulose prevents most or all of these pathologies in the fat fed hamster.  This model demonstrates that neither the dietary fat level, saturated fat level or carbohydrates alone are responsible for obesity-related metabolic diseases.  This study also shows that soluble celluloses increase fecal lipid excretion, not only cholesterol and bile acids, but triglycerides and other fatty acyl glycerides.  RT-PCR analysis shows that the hepatic gene, CYP51, is expressed at higher levels in soluble cellulose fed animals to maintain the cholesterol pool depleted by excretion of bile acids and cholesterol.  Stearoyl Co-A Desaturase, SCD, is expressed at lower levels in the soluble cellulose fed hamsters, suggesting either lower levels of fat absorption or a decreased rate of fat absorption.  The latter supports the excretion of fatty acyl glycerides in the feces.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov