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Title:   Author  item
                                            Cook, Danielitem
                                            Dayan, Franckitem
                                            Rimando, Agnesitem
                                            NANAYAKKARA, DHAMMIKA - UNIVERSITY OF MISSISSIPPIitem
                                            Pan, Zhiqiang

                                                         - *Peter*item
                                            Duke, Stephenitem
                                            Baerson, Scott
  Submitted to: American Chemical Society Symposium Series
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 12/30/2005
                                    Publication  Date: 1/20/2007
                                    Citation: Cook, D., Dayan, F.E., Rimando, A.M., Nanayakkara, D., Pan, Z., Duke, S.O., Baerson, S.R. 2007. Molecular and Biochemical Characterization of Novel Polyketide Synthases Likely To Be Involved in the Biosynthesis of Sorgoleone. American Chemical Society Symposium Series. 955:141-151.Interpretive Summary: This is a meeting proceedings/symposium publication and no interpretive summary is required.
                                Technical Abstract: Sorgoleone, an oily exudate secreted from the root hairs of sorghum (Sorghum bicolor (L.) Moench), acts as a potent allelochemical.  Its phytotoxic properties make the elucidation of the biosynthetic enzymes participating in this pathway desirable.  Previous studies suggest that the biosynthetic pathway of sorgoleone involves a polyketide synthase as well as a fatty acid desaturase, an O-methyl transferase, and a cytochrome P450 monooxygenase.  This polyketide synthase is proposed to use a novel long chain fatty acyl-CoA (C16:3) as a starter unit and catalyzes three iterative condensation reactions using malonyl-CoA to form a transient linear tetraketide that cyclizes to form a pentadecatriene resorcinol.  To identify the polyketide synthase gene(s) involved in the biosynthesis of these alkylresorcinols, a root-hair specific EST (expressed sequence tag) collection was mined for potential candidates.  A total of nine polyketide synthase-like EST’s were identified representing five unique contigs, three of which were preferentially expressed in root hairs. The molecular and biochemical characterization of these three candidate polyketide synthases are presented, two of which represent a novel type of type III plant polyketide synthase.


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