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Title:   Author  item
                                            Edrington, Thomasitem
                                            Callaway, Todditem
                                            Bischoff, Kennethitem
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Elder, Robertitem
                                            Anderson, Robinitem
                                            Nisbet, David
  Submitted to: Abstracts World Buiatrics Congress
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/21/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Escherichia coli 0157:H7 and Salmonella are widely recognized as important agents of food-borne disease. The use of ionophores in feeding ruminants is widespread in the United States and has attracted recent interest due to the apparent temporal relationship between ionophore use and the increase in E. coli 0157:H7 cases. Two experiments were conducted to evaluate the  effects of short-term feeding of ionophores on fecal shedding, intestinal concentrations, and antimicrobial susceptibility of E. coli 0157:H7 and Salmonella Typhimurium in growing lambs. Sixteen lambs were used in each experiment, four lambs per treatment group: monensin (MON), laidlomycin propionate (LP), bambermycin (BBM) and a control treatment). Lambs were fed their respective ionophore for 24 days. After 12 days on ionophores, lambs were experimentally infected with a non-toxigenic strain of E. coli 0157:H7 or Salmonella Typhimurium and fecal shedding was monitored daily. On day  24, lambs were humanely euthanized and tissues and contents sampled from the rumen, ileum, cecum, and rectum. No differences (P > 0.05) in fecal shedding of Salmonella or E. coli were found, although E. coli concentration appeared to decrease more quickly in control animals compared with ionophore treated animals. Gut contents and tissue samples for Salmonella or E. coli incidence were not different (P > 0.05) among treatments. These initial studies found minimal effects of short-term ionophore feeding on E. coli and Salmonella shedding or on anti-microbial susceptibility, but indicate that detailed, longer term studies are needed.


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