U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Natural Products Utilization Research: Oxford, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Location Research Units
                        National Sedimentation Laboratory
                                    Natural Products Utilization Research Unit
                                    Water Quality and Ecology Research Unit
                                    Watershed Physical Processes Research UnitSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Oxford, Mississippi Natural Products Utilization Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Cantrell, Charlesitem
                                            Case, Bethanyitem
                                            MENA, E. EDWARD - LIFEPHARMS, INC.item
                                            KNIFFIN, TOBY - LIFEPHARMS, INC.item
                                            Duke, Stephenitem
                                            Wedge, David
  Submitted to: Journal of Agricultural and Food Chemistry
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 4/28/2008
                                    Publication  Date: 6/17/2008
                                    Citation: Cantrell, C.L., Case, B.P., Mena, E., Kniffin, T.M., Duke, S.O., Wedge, D.E. 2008. Isolation and Identification of Antifungal Fatty Acids from the Basidiomycete Gomphus floccosus. Journal of Agricultural and Food Chemistry. 56:5062-5068.Interpretive Summary: Evolved microbial resistance to commercially available agrochemicals has led to a need for new pesticides. Furthermore, the desire for safe and more effective agrochemicals with reduced environmental and/or mammalian toxicity remains important. Natural product-based pesticides offer advantages, in that some can be specific towards a target species, and they often have unique modes of action with little mammalian toxicity. An additional benefit is that they generally have a relatively short environmental half life compared to synthetic pesticides. Our current research efforts are directed towards identifying natural product-based fungicides. The fruiting bodies of Gomphus floccosus (Schw.) Singer was investigated because preliminary screening data indicated the presence of fungitoxic compounds against the plant pathogens Colletotrichum fragariae, C. gloeosporioides, and C. acutatum. Three bioactive compounds were isolated, characterized, and evaluated for their antifungal activity.
                                Technical Abstract: Bioassay-guided fractionation of an ethyl acetate crude extract of the fruiting bodies of Gomphus floccosus (Schw.) Singer was performed because preliminary screening data indicated the presence of fungitoxic compounds against the plant pathogens Colletotrichum fragariae, C. gloeosporioides, and C. acutatum. Fractionation was directed using bioautography methods, resulting in the isolation of the bioactive fatty acids (10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (1), (9E,11Z)-13-oxo-9,11-octadecadienoic acid (2), and (10E,12E)-9-oxo-10,12-octadecadienoic acid (3). These three fatty acids were evaluated for activity against a greater range of fungal plant pathogens (C. fragariae, C. gloeosporioides, C. acutatum, Botrytis cinerea, Fusarium oxysporum, Phomopsis abscurans and P. viticola) in a growth inhibition bioassay at 45, 90, and 145 uM.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov