U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Liu, Linshuitem
                                            Kramer, Wendyitem
                                            Fishman, Marshallitem
                                            Hicks, Kevin
  Submitted to: Book Chapter
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 8/15/2005
                                    Publication  Date: 10/2/2006
                                    Citation: Liu, L.S., Kramer, W.H., Fishman, M.L., Hicks, K.B. 2006. Construction of gene delivery systems from biodegradable polysaccharides. Book Chapter In: "Chemistry as Art" Editors: L. Liu and G. E. Zaikov ISBN: 1-59454-585-5 p. 1-23.Interpretive Summary:
                                Technical Abstract: Gene therapy for the treatment and prevention of diseases on a genetic level is still in its infancy.  One of the major challenges in using gene therapy is finding efficient, safe and stable ways to introduce genes into target cells.  Although a whole panel of viral and non-viral vectors is available to introduce genetic materials into cells, a major drawback of most vectors is safety, lack of target cell specificity and low gene transfer efficiency.  At present, the in vivo gene expression levels for polysaccharide-derived gene vectors are lower than for viral vectors and for some synthetic polymer-gene vectors.  However, polysaccharide-derived gene vectors present several critical advantages over other vectors, such as safety, low immunogenicity, capability to deliver large genes and large-scale production at low-cost.  Thus, polysaccharide-gene vectors are preferred and have attracted increasing attention in the development of gene delivery technology.  In this review paper, research on the construction of polysaccharide-derived gene delivery vectors and the recent research trials about the controlled release of plasmid DNA are briefly discussed.  The paper places emphasis on the principle of polysaccharide-DNA vector preparation and occurring technical challenges.  Based on recent achievements and existing obstacles, novel strategies are suggested to improve the transfection efficiency of polysaccharide-gene delivery vectors.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov