U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Infectious Bacterial Diseases Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Infectious Bacterial Diseases Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            JUDGE, LAWRENCE - MICH. DEPT. OF AG.item
                                            Waters, Wadeitem
                                            Palmer, Mitchellitem
                                            BOLIN, STEVEN - MICH. STATE UNIVERSITY
  Submitted to: International Conference on Mycobacterium bovis
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/22/2005
                                    Publication  Date: 8/22/2005
                                    Citation: Judge, L.J., Waters, W.R., Palmer, M.V., Bolin, S.R. 2005. Population Differences in Test Specificity and Validation of Novel Antigens [abstract]. International Conference on Mycobacterium bovis. p. 70.Interpretive Summary:
                                Technical Abstract: The Gamma Interferon test (BovigamR) has been utilized by several countries for the diagnosis of bovine Tuberculosis; recently (2003) the United States Department of Agriculture approved the use of this test.  Michigan began using this test in 2004 with 2332 tests conducted statewide during the calendar year.  Michigan was granted split-state status (April, 2004); this necessitated the development of two distinct testing zones within the state.  As a result, Gamma Interferon test performance has been monitored separately in these zones; test specificity has been significantly lower in the lower disease status (bovine Tuberculosis endemic) zone than in the higher status (bovine Tuberculosis disease-free) zone.  This is the opposite of the expected result (of reduced specificity where disease prevalence is known to be higher) and has greatly limited the use of the test (high false positive rate) in some areas of the state.  Therefore, a validation study for the assessment of novel antigens for use with the Gamma Interferon test (ESAT-6/CFP-10) with the potential for improving test specificity has been initiated.  Field validation and subsequent approval of these antigens for use in the United States could greatly facilitate the adoption of the Gamma Interferon test in Michigan.  These antigens may also prove to be a useful addition to the BovigamR testing utilized in other states and nations bovine Tuberculosis testing programs.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov