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Title:   Author  item
                                            Brockmeier, Susanitem
                                            Baker, Amyitem
                                            Sacco, Randyitem
                                            Nicholson, Tracyitem
                                            Palmer, Mitchell
  Submitted to: American Society for Microbiology Meeting
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 2/16/2007
                                    Publication  Date: 5/21/2007
                                    Citation: Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.Interpretive Summary:
                                Technical Abstract: Coinfection with two or more pathogens is a common occurrence in respiratory diseases of most species.  The manner in which these pathogens interact is not always straightforward, however.  Bordetella bronchiseptica and swine influenza virus (SIV) are respiratory pathogens of pigs whose relatives, B. pertussis and human influenza viruses, cause respiratory disease in humans.  The effect of coinfection of SIV and B. bronchiseptica was examined in thirty-six, 4-week-old pigs (12 pigs per group) that were infected with SIV, B. bronchiseptica, or SIV and B. bronchiseptica.  An additional 12 pigs served as sham infected controls.  Four pigs from each group were euthanized at 1, 5 and 10 days post infection.  There was no difference in the frequency or amount of SIV isolated from the nasal cavity, trachea, or lung of pigs infected with SIV alone or coinfected with SIV and B. bronchiseptica.  However, there was a significantly greater amount of B. bronchiseptica isolated from coinfected pigs compared to pigs challenged with B. bronchiseptica alone from the nasal cavity late in the experiment (day 8 to 10 after challenge), and from both the trachea and lung at day 1 and day 10 after challenge.  Lung lesions in the coinfected pigs were more severe on day 1 and 10 after challenge, as compared to pigs infected with SIV or B. bronchiseptica alone, as well.  The differences in colonization and lung lesions were not seen on day 5 after challenge, when peak colonization or lesions occurred in groups infected with B. brochiseptica or SIV alone, respectively.  Interestingly, the amount of interferon alpha detected in the lung lavage was significantly higher in coinfected pigs compared to any of the other groups on day 1 after infection.  Thus, there appears to be a synergistic effect between SIV and B. bronchiseptica both in the prodromal and convalescent phases of infection, which may indicate an alteration of the innate and adaptive immune response to these pathogens.


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