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Title:   Author  item
                                            Brunelle, Brianitem
                                            Nicholson, Tracy
  Submitted to: Methods in Molecular Biology
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 1/1/2007
                                    Publication  Date: 11/1/2007
                                    Citation: Brunelle, B.W., Nicholson, T.L. 2007. Microarray - based approach for genome-wide survey of nucleotide polymorphisms. In: Bergman, Nicholas H., editor.  Methods in Molecular Biology. Totowa, NJ: Humana Press. p. 267-280.Interpretive Summary:
                                Technical Abstract: DNA microarrays can be used to detect polymorphic loci in addition to identifying genes or regions that are absent within a genome.  A survey such as this offers greater insight into the level of diversification within a species or population.  This is especially useful in organisms that have near-identical genomic content, but vary in phenotype, as the identification of such polymorphic loci can lead to the characterization of genes linked to unique biological attributes.  Here we describe a competitive hybridization assay using DNA microarrays as a comparative genomics tool to identify nucleotide polymorphisms among the closely related strains of Chlamydia trachomatis.


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