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Title:   Author  item
                                            Lillehoj, Hyunitem
                                            LEE, SUNG - VISITING SYitem
                                            DALLOUL, RAMI - VISITING SY
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/31/2006
                                    Publication  Date: 10/21/2006
                                    Citation: Hong, Y.H., Lillehoj, H.S., Lee, S.H., Dalloul, R. 2006. Kinetic changes in immune-related gene expression and intestinal lymphocyte subpopulations following e. maxima infection. Proceedings of International Avian Immunology Research Group Meeting. Oct 21-24, Paris, France. P 64.Interpretive Summary:
                                Technical Abstract: Coccidiosis, a major intestinal parasitic disease of poultry, induces a cell-mediated immune response against the etiologic agent of the disease, Eimeria.  In the current study, the expression levels of gene transcripts encoding pro-inflammatory, Th1, and Th2 cytokines, as well as chemokines and intestinal intraepithelial lymphocyte subpopulations, were quantified following E. maxima infection.  Transcripts of the pro-inflammatory and Th1 cytokines IFN-gamma, IL-1 beta, IL-6, IL-12, IL-15, IL-17, and IL-18 were increased 66- to 80,000,000-fold following primary coccidiosis.  Similarly, mRNA levels of the Th2 cytokines IL-3, IL-10, IL-13, and GM-CSF were up-regulated 34- to 8,800-fold, and the chemokines IL-8, lymphotactin, MIF, and K203 were increased 42- to 1,756-fold.  In contrast, IFN-alpha, TGF-beta4, and K60 transcripts showed no increased expression, and only the level of the Th2 cytokine IL-13 was increased following secondary E. maxima infection. Intestinal T cell subpopulations CD3+, CD4+, and CD8+ cells were significantly increased at days 8, 6, and 7 days post primary E. maxima infection, but only CD4+ cells remained elevated following secondary infection. TCR1+ cells exhibited a biphasic pattern following primary infection, whereas TCR2+ cells displayed a single peak in levels.  Taken together, these data indicate a global chicken intestinal immune response is produced following experimental Eimeria infection involving multiple cytokines, chemokines, and T cell subsets.


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