U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Virus and Prion Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Virus and Prion Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            LEKCHAROENSUK, PORNTIPPA - KASETSART UNIV, BANGKOKitem
                                            Lager, Kellyitem
                                            VEMULAPALLI, RAMESH - PURDUE UNIVERSITYitem
                                            WOODRUFF, MARY - PURDUE UNIVERSITYitem
                                            Baker, Amyitem
                                            Richt, Juergen
  Submitted to: Emerging Infectious Diseases
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/9/2006
                                    Publication  Date: 5/1/2006
                                    Citation: Lekcharoensuk, P., Lager, K.M., Vemulapalli, R., Woodruff, M., Vincent, A.L., Richt, J.A. 2006. Novel swine influenza virus subtype H3N1, United States. Emerging Infectious Diseases. 12(5):787-794.Interpretive Summary: Influenza A virus infects various animal species and transmits among different hosts, especially between humans and swine. Pigs may serve as a mixing vessel to create new reassortants that could infect humans. Here we report the emergence and characterization of a novel swine influenza virus (SIV) subtype in the Midwestern United States. This new H3N1 subtype acquired the hemagglutinin gene from an H3N2 turkey virus, the neuraminidase gene from a human H1N1 virus, and the remaining genes from currently circulating SIVs. Pigs inoculated with the H3N1 SIVs produced lung lesions and shed the viruses in nasal secretions.  This is the first description of this new subtype of swine influenza viruses in U.S. swine. If these novel viruses continue to circulate in the U.S. swine population, the reported molecular characterization of these novel swine viruses will allow us to design better diagnostic tools and vaccination strategies.
                                Technical Abstract: Influenza A virus infects various animal species and transmits among different hosts, especially between humans and swine. Pigs may serve as a mixing vessel to create new reassortants that could infect humans. Thus, monitoring and characterization of influenza viruses in swine is important for the prevention of interspecies transmission. Here we report the emergence and characterization of a novel H3N1 subtype of swine influenza virus (SIV) in the United States. Phylogenetic analysis revealed that the H3N1 SIVs may have acquired the hemagglutinin gene from an H3N2 turkey virus, the neuraminase gene from a human H1N1 virus, and the remaining genes from currently circulating SIVs. The H3N1 SIVs were antigenically related to the turkey virus. Pigs inoculated with the H3N1 SIVs produced lung lesions and nasal shedding, suggesting the potential to transmit among swine and to humans. Whether this novel subtype will continue to circulate in swine population needs further surveillance.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov