U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Infectious Bacterial Diseases Research: Ames, IA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Midwest Area Ames, Iowa National Animal Disease Center Infectious Bacterial Diseases Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            NOL, PAULINE - USDA/APHISitem
                                            Waters, Wadeitem
                                            Palmer, Mitchellitem
                                            ALDWELL, FRANK - UNIV. OF OTAGO, NEW ZEALitem
                                            BUDDLE, BRYCE - AG RESEARCH, NEW ZEALANDitem
                                            RHYAN, JACK - USDA/APHISitem
                                            DUNBAR, MIKE - USDA/APHISitem
                                            SALMAN, MO - COLORADO STATE UNIV.
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/6/2006
                                    Publication  Date: 8/6/2006
                                    Citation: Nol, P., Waters, W.R., Palmer, M.V., Aldwell, F.E., Buddle, B.M., Rhyan, J.C., Dunbar, M., Salman, M.D. 2006. Efficacy of Oral and Parenteral Bacille Calmette-Guerin (BCG Danish Strain 1331) in Protecting White-tailed Deer (Odecoileus Virginianus) against Bovine Tuberculosis [abstract]. p. 25.Interpretive Summary:
                                Technical Abstract: Wildlife Disease Association Annual Conference, August 6-10, 2006
Terry Amundson Student Presentation Award
Oral Presentation

EFFICACY OF ORAL AND PARENTERAL BACILLE CALMETTE-GUERIN (BCG DANISH STRAIN 1331) IN PROTECTING WHITE-TAILED DEER (ODECOILEUS VIRGINIANUS) AGAINST BOVINE TUBERCULOSIS

Pauline Nol, USDA/APHIS National Wildlife Research Center, Fort Collins, CO, 80521; W. Ray Waters, USDA/ARS National Animal Disease Center, Ames, IA, 50010; Mitchell V. Palmer, USDA/ARS National Animal Disease Center, Ames, IA, 50010; Frank E. Aldwell, University of Otago, Dunedin, NZ; Bryce M. Buddle, AgResearch, Wallaceville Animal Research Centre, Upper Hutt, NZ; Jack C. Rhyan, USDA/APHIS National Wildlife Research Center, Fort Collins, CO, Mike Dunbar, USDA/APHIS National Wildlife Research Center, Fort Collins, CO 80521; Mo D. Salman, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, 80523

Bovine tuberculosis poses a serious continual threat to the health and economic well-being of both livestock and humans worldwide.  Free-ranging white-tailed deer (Odecoileus virginianus) in the state of Michigan (USA) have been shown to be endemically infected with Mycobacterium bovis, and serve as a potential reservoir of infection to livestock, other wildlife species, and humans, representing a significant obstacle to that state’s disease eradication efforts.  An effective vaccination program, involving a mucosal vaccine that can be distributed in the field, would be essential for disease management on a herd-wide level.  
We investigated the efficacy of oral and parenteral bacille Calmette-Guerin (BCG) in its ability to protect white-tailed deer against disease caused by M. bovis infection.  Thirty white-tailed deer were divided into four groups.  One group was vaccinated with 10**6 colony forming units (cfu) BCG (Danish strain 1331) subcutaneously, one group received 10**9 cfu BCG in culture directly to the oropharynx, one group received 10**9 cfu BCG via a lipid-formulated oral bait, and the last group received a placebo directly to the oropharynx.  Blood samples were taken throughout the study in order to investigate levels of cellular and humoral responses in this species to BCG vaccination and M. bovis challenge after vaccination.  Four months post-challenge, the animals were examined for lesions.  Results indicate that both oral forms of BCG offered significant protection against M. bovis challenge as compared to placebo.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov