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- Rebecca Milczarek *(Scopus)*
- Yuzhu Zhang *(PubMed)*

Title:   Author  item
                                            Shao, Qimingitem
                                            WLASCHIN, KATIE - UNIV. OF MINNESOTA, MNitem
                                            Yokoyama, Wallace

                                                         - *Wally*item
                                            NISSOM, PETER - BIOPRO TECH INST, SINGAPOitem
                                            YAP, MIRANDA - BIOPRO TECH INST, SINGAPOitem
                                            HU, WEI-SHOU - UNIV. OF MINNESOTA, MNitem
                                            Lazo, Gerard
  Submitted to: Meeting Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 3/13/2005
                                    Publication  Date: 3/13/2005
                                    Citation: Shao, Q., Wlaschin, K., Yokoyama, W.H., Nissom, P.M., Yap, M., Hu, W., Lazo, G.R. 2005. Hydroxypropylmethylcellulose (HPMC) May Prevent Insulin Resistance in Hamsters Fed High Saturated Fat Diets through Regulating Metabolic Genes. Meeting Abstract Paper AGFD #103, ACS Cornucopia, 3/15/05, San Diego, CA.Interpretive Summary:
                                Technical Abstract: Syrian hamsters fed a high fat (HF) diet similar in fat content to the American diet become insulin resistant (IR).  We have shown earlier that replacing cellulose in this HF diet with hydroxypropylmethylcellulose (HPMC) significantly decreases the incidence of IR.  HPMC significantly reduced the glucose infusion rate, fasting plasma insulin, plasma lipids, overall fat distribution in non-adipose tissues, and the cell size of adipose tissues.  The underlying mechanisms of these beneficial physiological effects are unknown.  A cDNA microarray, constructed from Chinese hamster ovary cells, was used to analyze gene expression in liver tissues from hamsters fed the HF or the HF with HPMC diets.  Genes related to fat metabolism, glucose metabolism, insulin metabolism, inflammation, and glucose transport, were differentially expressed between the two groups.   These results indicate that HPMC may prevent the cellular oxidative damage leading to diabetes by normalizing fat metabolism.


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