U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Food and Feed Safety Research: College Station, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area College Station, Texas Southern Plains Agricultural Research Center Food and Feed Safety Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Callaway, Todditem
                                            Anderson, Robinitem
                                            Edrington, Thomasitem
                                            Bischoff, Kennethitem
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Poole, Toniitem
                                            Harvey, Rogeritem
                                            Byrd Ii, James

                                                         - *Allen*item
                                            Nisbet, David
  Submitted to: Current Issues in Intestinal Microbiology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/17/2004
                                    Publication  Date: 3/8/2004
                                    Citation: Callaway, T.R., Anderson, R.C., Edrington, T.S., Bischoff, K.M., Genovese, K.J., Poole, T.L., Harvey, R.B., Byrd II, J.A., Nisbet, D.J. 2004. Effects of sodium chlorate on toxin production by Escherichia coli O157:H7. Current Issues in Intestinal Microbiology. 5:19-22.Interpretive Summary: Escherichia coli O157:H7 is a food borne pathogenic bacterium that is killed by the addition of sodium chlorate.  Toxin production by E. coli O157:H7 is dramatically increased when this bacterium is treated with traditional, medically-important antibiotics; thus causing a negative impact on human health.  Because of this increase in toxin production, antibiotics are not recommended for use in human infections by E. coli O157:H7.  This study demonstrates that chlorate does not increase toxin production by strains of E. coli O157:H7.  This result indicates that chlorate could be used to treat a broad range of E. coli O157:H7 infections without fear of stimulating toxin production.
                                Technical Abstract: Chlorate kills E. coli O157:H7 and has been proposed as a feed additive to be included in cattle rations immediately prior to slaughter to reduce E. coli O157:H7 populations in the gut. Antibiotic usage is not recommended in cases of E. coli O157:H7-induced hemorrhagic colitis because some antibiotics stimulate toxin production.  This study was undertaken to determine if chlorate treatment affected toxin production.  Pure cultures of E. coli O157:H7 were treated with 1⁄4 MIC of antibiotics (ampicillin, tetracycline, ceftiofur, gentamicin, monensin, tylosin, penicillin, ciprofloxacin, and novobiocin); toxin production was significantly increased by some antibiotics, but not by chlorate.  Studies with mixed fecal bacteria demonstrated that chlorate killed E. coli O157:H7, but again did not stimulate toxin production.  Chlorate appears to be an effective method to reduce shiga toxin-producing E. coli (STEC) populations in food animals, but additional studies are warranted before it is used to control infections.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov