U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Brockmeier, Susanitem
                                            LOVING, CRYSTAL - IOWA STATE UNIVERSITYitem
                                            Nicholson, Tracyitem
                                            Palmer, Mitchell
  Submitted to: American Society for Microbiology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 6/5/2005
                                    Publication  Date: 6/5/2005
                                    Citation: Brockmeier, S., Loving, C.L., Nicholson, T.L., Palmer, M.V. 2005. Coinfection with porcine respiratory coronavirus and bordetella bronchiseptica in pigs. American Society for Microbiology. Z016, p. 614.Interpretive Summary:
                                Technical Abstract: Coinfection with two or more pathogens is a common occurrence in respiratory diseases of most species.  The manner in which these pathogens interact is not always straightforward, however.  Bordetella bronchiseptica and porcine respiratory coronavirus (PRCV) are respiratory pathogens of pigs whose relatives, B. pertussis and the SARS virus, cause respiratory disease in humans.  The effect of coinfection of PRCV and B. bronchiseptica was examined in thirty, 4-week-old pigs (10 pigs per group) that were infected with PRCV, B. bronchiseptica, or PRCV and B. bronchiseptica.  An additional 10 pigs served as sham infected controls.  Five pigs from each group were euthanized at 4 and 10 days post infection.  In the two groups which were infected with virus, PRCV was isolated from the lung lavage of pigs at 4 days post infection but not at 10 days post infection.  However, lung lesions were present at both time points and were more severe at 10 days post infection in these two groups.  In both groups infected with the bacteria, B. bronchiseptica was cultured from all pigs at both 4 and 10 days post infection.  Gross and histopathological lung lesions were more severe in the coinfected group as compared to the groups infected with B. bronchiseptica or PRCV alone.  The difference was most pronounced at 10 days post infection, when the mean percentage of lung affected in the coinfected group was 19 percent compared to 5.5 percent and 1.4 percent for the groups infected with PRCV or B. bronchiseptica alone, respectively.  Thus, there appears to be a synergistic effect between PRCV and B. bronchiseptica with regards to severity of pneumonia in swine, although the fact that the most severe lesions occurred when the pathogens were being cleared may indicate that the lesions are due to the immune response to the pathogens rather than the presence of the pathogens themselves.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov