U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            ROSYPAL, ALEXA - VIRGINIA TECHitem
                                            LINDSAY, DAVID - VIRGINIA TECHitem
                                            DUNCAN, JR., ROBERT - VIRGINIA TECHitem
                                            AHMED, S. - VIRGINIA TECHitem
                                            ZAJAC, ANNE - VIRGINIA TECHitem
                                            Dubey, Jitender
  Submitted to: Veterinary Parasitology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/9/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Sarcocystis neurona is a single-celled parasite that causes a fatal disease in horses (EPM).  Little is known of the pathogenesis of EPM because there is no suitable animal model for it.  Certain cytokines (substances released by lymphocytes) are considered important mediators of immunity to parasites.  Scientists at the Beltsville Agricultural Research Center and  the Virginia Tech, Blacksburg, Virginia have found that nitric oxide release is not a mechanism involved in the pathogenesis of EPM.  These results will be of interest to biologists, parasitologists and immunologists.
                                Technical Abstract: Equine protozoal myeloencephalitis (EPM) is a neurologic syndrome in horses from the Americas and is usually caused by infection with the apicomplexan parasite, Sarcocystis neurona.  Little is known about the role of immunobiological mediators to this parasite.  Nitric oxide is important in resistance to many intracellular parasites.  We therefore investigated the  role of inducible and endothelial nitric oxide in resistance to clinical disease cause by S. neurona in mice.  Groups of interferon-y gene knockout (IFN-y-KO) mice, inducible nitric oxide synthase gene knockout (eNOS-KO) and appropriate genetic background mice (BALB/c or C57BL/6) were orally fed sporocysts of Hanks balanced salt solution.  Mice were observed for signs of clinical disease and at necropsy.  Clinical disease and deaths occurred only in the IFN-y-KO mice.  Results of this study indicate that iNOS and eNOS are not major mediators of resistance to S. neurona infections.  Results of this study suggest that IFN-y mediated immunity to S. neurona may be mediated by non-nitric oxide dependent mechanisms.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov