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Title:   Author  item
                                            TOUCHETTE, K - UNIVERSITY OF MISSOURIitem
                                            ALLEE, G - UNIVERSITY OF MISSOURIitem
                                            Matteri, Robertitem
                                            DYER, C - MONSANTOitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/28/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Previously, we reported that pigs fed spray-dried plasma (SDP) have greater hypothalamic-pituitary-adrenal (HPA) axis and immune system responses following a lipopolysaccharide (LPS) challenge than pigs fed a diet with no SDP.  The objective of this study was to evaluate mRNA expression of hormones in tissues associated with the HPA axis.  Twenty pigs (14 d, 5 kg) )were weaned to an isolated environment and allotted to 1 of 4 treatments i a 2x2 factorial arrangement, with two levels of SDP (0 vs 7%) and two i.p. injections (LPS vs saline).  Diets were formulated to contain equal ME and digestible essential amino acids and fed for 7 d postweaning.  On d 7, i.p. injections of LPS (150 ug/kg BW) or saline were given.  After 3 h, pigs were sacrificed and tissue was collected for mRNA analysis.  Tissue mRNA levels measured were not affected by LPS treatment.  Pigs fed the diet with SDP had a lower level of hypothalamic CRH mRNA compared to pigs fed the  diet without SDP (P<.05).  Pigs fed the diet with SDP also had a lower level of CRH receptor mRNA in the pituitary compared to pigs fed the diet without SDP (P=.12).  Dietary treatment did not affect POMC mRNA in the pituitary.  Pigs fed the diet with SDP had a lower level of adrenal ACTH receptor mRNA compared to pigs fed the diet without SDP (P<.05).  These results suggest that the HPA axis of pigs fed SDP after weaning may be less activated than that of pigs fed a diet without SDP.  Considering the well-known effect of pathogen exposure as a stimulator of the HPA axis, our observation of a lower level of HPA activation may reflect a decreased immune activation as previously reported.  Thus, feeding SDP may provide immunological protection for weaned pigs under typical production conditions and reduce basal activation of the HPA axis.


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