U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Food and Feed Safety Research: College Station, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area College Station, Texas Southern Plains Agricultural Research Center Food and Feed Safety Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Harvey, Rogeritem
                                            Andrews, Kathleen

                                                         - *Kate*item
                                            Droleskey, Robert

                                                         - *Bob*item
                                            KANSAGRA, KETAN - ST. PETER'S UNIV HOSPITALitem
                                            STOLL, BARBARA - BAYLOR COLLEGE OF MEDICINitem
                                            Burrin, Douglas

                                                         - *Doug*item
                                            Sheffield, Cynthiaitem
                                            Anderson, Robinitem
                                            Nisbet, David
  Submitted to: Current Issues in Intestinal Microbiology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/1/2005
                                    Publication  Date: 5/20/2006
                                    Citation: Harvey, R.B., Andrews, K., Droleskey, R.E., Kansagra, K.V., Stoll, B., Burrin, D.G., Sheffield, C.L., Anderson, R.C., Nisbet, D.J. 2006. Qualitative and quantitative comparison of gut bacterial colonization in enterally and parenterally fed neonatal pigs. Current Issues in Intestinal Microbiology. 7:61-64.Interpretive Summary: Because pre-term human infants usually can't be orally fed, they must be fed intravenously.  This often puts them at risk for infection and death. We used a baby pig model to determine what factors lead to bacterial infection and found that newborns need to get "good bacteria" in their gut as soon as possible.  A suitable intervention could include the treating of premature babies with beneficial gut bacteria.  If successful, this has the potential for application in assuring good nutritional health of pre-term human infants.
                                Technical Abstract: Total parenteral nutrition (TPN) has been associated with sepsis, translocation of gut luminal bacteria, gut mucosal atrophy, impaired gut barrier function, and increased gut permeability in preterm human infants. In this study, we sought to compare the composition of microbiota in the neonatal pig gut to translocation events and to examine the effects of TPN versus enteral (ENT) feeding on early gut colonization.  Newborn, colostrum-deprived pigs (<24 h old) were fitted with intravenous catheters and divided into two groups.  One group (n = 13) received total TPN through intravenous feeding and the second group (n = 13) (enteral-ENT) was fed a commercial milk replacer.  After 7 d of treatment, pigs were euthanized and samples were collected for bacterial culture from the blood, intestinal tract and organs.  ENT pigs had increased bacterial diversity (number of species isolated), higher concentrations of bacteria, and bacterial colonization of all segments of the intestinal tract compared to the TPN pigs.  Translocation of bacteria from the intestinal tract to tissues or blood was similar for both groups.  The ENT group had 1/13 positive for Clostrium difficile toxin A whereas the TPN group had 5/13.  We concluded that TPN was not positively associated with translocation, that ENT favored increased bacterial concentrations comprised of more speciation in the gastrointestinal tract compared to TPN, and that TPN-treated neonates were at higher risk of colonization by toxin-expressing strains of C. difficile.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov