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Title:   Author  item
                                            MIN, WONGI - 1265-40-00item
                                            Lillehoj, Hyunitem
                                            KIM, SUNGWON - 1265-40-00item
                                            ZHU, JAMES - 1265-40-00item
                                            BEARD, HUNTER - SOY ALF RES LABitem
                                            ALKHAROUF, NADIM - SOY ALF RES LABitem
                                            MATTHEWS, BENJAMIN - SOY ALF RES LAB
  Submitted to: Annual Conference on Vaccine Research
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 6/2/2002
                                    Publication  Date: 7/5/2003
                                    Citation: MIN, W., LILLEHOJ, H.S., KIM, S., ZHU, J., BEARD, H., ALKHAROUF, N., MATTHEWS, B.F. PROFILING GENE EXPRESSION CHANGES ASSOCIATED WITH EIMERIA INFECTIONS USING HIGH-THROUGHPUT CDNA MICROARRAY. Annual Conference on Vaccine Research. 2003.Interpretive Summary:
                                Technical Abstract: Global transcriptional changes induced in the chicken intestinal intraepithelial lymphocytes (IELs) in response to an intracellular parasitic infection were investigated using nylon and glass cDNA microarrays.  Chicken EST cDNAs were selected from the cDNA libraries developed from the activated T-lymphocytes and macrophages (www.chickest.udel.edu). To identify host genes induced by Eimeria infections, we hybridized cDNA microarrays with intestinal mRNA samples obtained from chickens infected with E. acervulina or E. maxima. Among the 2,600 EST clones initially screened, 419 clones were selected on the basis of at least 1.5 folds increased or decreased expression over the uninfected controls. Following infection with E. acervulina or E. maxima, 9.5% and 2.3% of total EST clones tested were increased, and 10.7% and 2.3% were repressed following primary and secondary infections, respectively. In general, E. acervulina infection resulted in a greater change in local gene expression than E. maxima infection. The detailed analysis of local changes in host gene expression following Eimeria infections will enhance our understanding of host-parasite immunobiology leading to protective immunity.


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