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Title:   Author  item
                                            YI, G - UNIV OF MISSOURIitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            ALLEE, G - UNIV OF MISSOURIitem
                                            GAINES, A - UNIV OF MISSOURIitem
                                            KENDALL, D - UNIV OF MISSOURIitem
                                            TORIDE, Y - AJINOMOTO CO. INC.item
                                            IZURU, I - AJINOMOTO CO. INC.
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 10/30/2002
                                    Publication  Date: 3/17/2003
                                    Citation: YI, G.F., CARROLL, J.A., ALLEE, G.L., GAINES, A.M., KENDALL, D.C., TORIDE, Y., IZURU, I. IMPACT OF GLUTAMINE AND SPRAY-DRIED PLASMA ON GROWTH PERFORMANCE, SMALL INTESTINAL MORPHOLOGY, AND IMMUNE RESPONSES IN ESCHERICHIA COLI K88+ CHALLENGED WEANED PIGS. JOURNAL OF ANIMAL SCIENCE SUPPLEMENT. 2003. V. 81(Suppl.2):Abstract p. 38.Interpretive Summary:
                                Technical Abstract: A total of 40 barrows (5.32 +/- 0.3 kg) weaned at 17 +/- 2 days of age were used to investigate the effects of feeding glutamine (GLN) and spray-dried plasma (SDP) diets on E. coli K88+ LT/STb**+ challenged pigs. Pigs were allotted in a RCBD to four dietary treatments which included:  positive control (POS), negative control (NEG), SDP, and GLN treatments. The POS and NEG were fed the same corn-soy-whey diet, whereas the SDP and GLN were fed 7% SDP and 2% GLN supplemented diets, respectively. On d 11 postweaning, all pigs were fitted with indwelling jugular catheters. On d 12 postweaning, pigs on the NEG, SDP, and GLN were orally challenged with 5.5 X 10**8 CFU E. coli K88**+, whereas pigs on the POS were treated with skim milk. Rectal temperature and fecal diarrheic scores were recorded and blood samples collected, at 0, 6, 12, 24, 36, and 48 h postweaning for serum hormone and cytokine measurements. At 48 h post-challenge, all pigs were sacrificed for small-intestinal morphology evaluation. At 48 h post-challenge, compared to the non-challenged POS, pigs on the NEG had decreased ADG and G:F (P < 0.08). However, feeding both SDP and GLN alleviated growth depression and feed efficiency reduction associated with E. coli challenge. At 12 h post-challenge, pigs on NEG had the highest incidence of diarrhea among treatments (P < 0.09). There were no treatment X time interactions for rectal temperature (P > 0.81), ACTH (P > 0.74), cortisol (P > 0.43), or IL-6 (P > 0.10) during the E. coli challenge period. In proximal, mid-jejunum and ileum, compared with POS, pigs on NEG had greater villous atrophy and intestinal morphology disruption (P < 0.08), whereas feeding both SDP and GLN mitigated or prevented villous atrophy and intestinal morphology impairment after E. coli challenge. At 6 h post-challenge, compared to baseline measurement, all pigs had increased GH (P < 0.001) and decreased IGF-1 (P < 0.001). At 12 h post-challenge, pigs on POS had higher IGF-1 compared to the E. coli-challenged pigs (P < 0.08). These results indicate that feeding SDP and GLN have beneficial effects in alleviating growth depression of E. coli K88**+ challenged pigs mainly via maintaining intestinal morphology and function, and possibly via modulating the somatotrophic axis.


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