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Title:   Author  item
                                            Wang, Shiowitem
                                            Lewers, Kimberlyitem
                                            BOWMAN, LINDA - NIOSH,CDC,MORGANTOWN,WVitem
                                            DING, MIN - NIOSH,CDC,MORGANTOWN,WV
  Submitted to: American Society of Horticulture Science Meeting
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/21/2006
                                    Publication  Date: 7/6/2006
                                    Citation: Wang, S.Y., Lewers, K.S., Bowman, L., Ding, M. 2006. Strawberries inhibit cancer cell proliferation. American Society of Horticulture Science Meeting. 41(4):1082Interpretive Summary:
                                Technical Abstract: Representatives of three species of strawberries (Fragaria virginiana, F. chiloensis and F. ×ananassa) were evaluated for antioxidant capacity, scavenging capacity for reactive oxygen species (ROO', 'OH , 1O2 and O2 ' -), and inhibitory effect on proliferation of A549 human lung epithelial cancer cells. Differences among the strawberry genotypes were observed for all three qualities. High antioxidant and scavenging capacities were found in ‘CFRA 0982’, ‘JP 95-1-1’, NC 95-19-1 and RH 30. Lowest antioxidant and scavenging capacities were found in ‘Allstar’.  There was also a relationship between scavenging capacity and the inhibition of cancer cell proliferation. The correlations (R2) between the scavenging capacities for the reactive oxygen species and the inhibition of cancer cell proliferation were 0.8074, 0.8279, 0.7862 and 0.7761 for ROO', 'OH , 1O2 and O2 ' -, respectively. These results suggest that antioxidants, specifically, their scavenging capacities, may play an important role in the antiproliferative activity of strawberries. This study also identified strawberry germplasm of value in developing cultivars useful towards cancer prevention.


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