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Title:   Author  item
                                            BLACKSTON, C - CDC, ATLANTA GAitem
                                            Dubey, Jitenderitem
                                            DOTSON, E - CDC, ATLANTA GAitem
                                            SU, C - WASH'TON UNIV,ST.LOUIS MOitem
                                            TUILLIEZ, P - INST PUERICULTURE, PARISitem
                                            SIBLEYD  - WASH'TON UNIV,ST.LOUIS MOitem
                                            LEHMANN, T - CDC, ATLANTA GA
  Submitted to: Journal of Parasitology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/25/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Infection by the protozoan (single-celled) parasite, Toxoplasma gondii, are widely prevalent in humans and anmals.  It causes mental retardation and loss of vision in congenitally-infected children and abortion in livestock.  There is a single species of the parasite in the genus Toxoplasma, T. gondii.  Scientists at  the Beltsville Agricultural Research Center and the CDC, Atlanta, Georgia describe a new high resolution system for typing strains of T. gondii. These results will be of interest to biologists, parasitologists and geneticists.
                                Technical Abstract: High resolution typing of Toxoplasma gondii is essential to understand the effect of genetic differences among strains on the variation in disease manifestation and transmission patterns. Current typing methods discern 3 lineages with minimal within-lineage variation.  Described here are 6 new variable  loci.  These loci, including a minisatellite and 5 microsatellites, were more polymorphic than allozymes, RFLPs, and sequence variation in introns.  Most importantly, these loci revealed, for the first time, substantial within-lineage variation that was over 6-fold higher than that detected by other markers.  Genotyping at these loci facilitates classification of isolates beyond the lineage level.


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