U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Min, Wongiitem
                                            Lillehoj, Hyun
  Submitted to: Avian Immunology Group Meeting
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/1/2004
                                    Publication  Date: 9/1/2004
                                    Citation: Min, W., Lillehoj, H.S. 2004. Molecular and functional characterization of an alternatively spliced transcript isoform of the common cytokine receptor gamma chain. Avian Immunology Group Meeting, p. 83.Interpretive Summary:
                                Technical Abstract: The common cytokine receptor gamma (gamma c) chain is a shared component of the receptors for IL-2, -4, -7, -9, -15, and -21, and is a member of the cytokine receptor superfamily displaying a characteristic spacing of four conserved cysteine residues and a WSXWS motif.  The gammac chain is expressed as a transmembrane glycoprotein on CD4+ and CD8+ T cells, B cells, NK cells, monocytes/macrophages, neutrophils, and granulocytes where it forms heterodimeric or heterotrimeric complexes with specific interleukin receptors thereby augmenting ligand affinity, receptor internalization, and signal transduction.  In this study, we discovered that, unlike mammals, chickens possess two different gamma gamma c gene transcripts, chgammac-a and chgammac-b.  Sequence comparisons between the cDNAs and a gammac genomic clone isolated by PCR revealed that chgammac-b contained an in-frame 78 bp insertion between Gly-222 and Val-223 of the chgammac-a sequence.  This insertion most likely resulted from alternative mRNA splicing such that the 5th intron was not removed from the chgammac-b transcript.  Furthermore, while chgammac-a and chgammac-b transcripts were expressed equally in the spleen, thymus, bursa, and cecal tonsils, they were differentially expressed during the time course of Con A stimulation of splenic T lymphocytes.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov