Exhibit
      10.3




FIRST
        AMENDMENT TO
 RESTRICTED
        STOCK UNIT AGREEMENT
  This
        FIRST AMENDMENT TO RESTRICTED STOCK UNIT AGREEMENT (the “First Amendment”), is
        entered into effective September 28, 2007, by and between POZEN Inc. (“POZEN” or
        the “Company”), and John R. Plachetka (the “Grantee”).
  RECITALS
  WHEREAS,
        a Restricted Stock Unit Agreement dated as of February 14, 2007, and issued
        under the POZEN Inc. 2000 Equity Compensation Plan, as amended and restated,
        was
        delivered by POZEN to the Grantee (the “Original Agreement”); and
  WHEREAS,
        POZEN and the Grantee desire to amend certain terms of the Original Agreement
        as
        set forth below.
  NOW,
        THEREFORE, the parties to this Agreement, intending to be legally bound hereby,
        agree as follows:
  1.  Any
        capitalized terms not defined herein shall have the meanings ascribed to
        such
        terms in the Original Document.
  2.  Section
        5(a) of the  Original Agreement is hereby amended and restated in its
        entirety as follows:
  “(a)
        (i)                      It
        is intended that the Restricted Units will be distributed in accordance with
        Section 409A of the Internal Revenue Code of 1986, as amended, and the
        regulations promulgated thereunder (“Section 409A”).  On the fifth
        (5th) business
        day after the Grantee separates from service with POZEN (as defined under
        Section 409A), POZEN will issue to the Grantee one share of Common Stock
        for
        each whole Restricted Unit credited to the Restricted Unit Account that was
        vested on the date of Grantee’s separation from service (without regard to any
        acceleration of vesting provided for in Paragraph 4(b)), subject to satisfaction
        of the Grantee’s tax withholding obligations as described below, and except as
        described below.  If applicable, on the ninetieth (90th) day
        after the
        Grantee separates from service with POZEN, POZEN will issue to the Grantee
        one
        additional share of Common Stock for each whole Restricted Unit that shall
        have
        vested pursuant to the acceleration provisions of Paragraph 4(b), provided
        that
        Grantee has executed and not revoked the Release and subject to satisfaction
        of
        the Grantee’s tax withholding obligations as described below, and except as
        described below.
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  (ii)           If
        a Change of Control (as defined below) occurs before the Grantee has separated
        from service with POZEN, on the closing date of the Change of Control, subject
        to and in accordance with Paragraph 6 below and the other provisions of the
        Plan
        applicable to a Change of Control, POZEN will issue to the Grantee one share
        of
        Common Stock for each whole vested Restricted Unit credited to the Restricted
        Unit Account, subject to satisfaction of the Grantee’s tax withholding
        obligations as described below. Any vested amounts representing partial shares
        shall be paid in cash.
  (iii)           Notwithstanding
        the foregoing provisions of this Section 5, if the Grantee on the date of
        Grantee’s separation from service is a “specified employee” (as defined under
        Section 409A and as determined in accordance with the permissible method
        then in
        use by POZEN, or, if none, in accordance with the applicable default provisions
        of Section 409A, relating to “specified employees),” then if and to the extent
        required in order to avoid the imposition on the Grantee of any tax under
        Section 409A, the foregoing shares of Common Stock shall not be issued by
        the
        Company until the first business day after the date that is six (6) months
        after
        the date of Grantee’s separation from service.”
  3.  Section
        6
        of the Original Agreement is hereby amended and restated in its entirety
        as
        follows:
  “Change
        of Control.  The provisions of the Plan applicable to a Change of
        Control shall apply to the Restricted Units; provided, however, that for
        purposes of this Agreement, a “Change of Control” shall be deemed to have
        occurred:
  (i)           if
        any “person” (as such term is used in sections 13(d) and 14(d) of the Securities
        Exchange Act of 1934, as amended) (other than the Company or any trustee
        or
        fiduciary holding securities under an employee benefit plan of the Company)
        becomes a “beneficial owner” (as defined in Rule 13d-3 under the Exchange Act),
        directly or indirectly, of securities of the Company representing more than
        50%
        of the voting power of the then outstanding securities of the Company; provided
        that a Change of Control shall not be deemed to occur as a result of a
        transaction in which the Company becomes a subsidiary of another corporation
        and
        in which the stockholders of the Company, immediately prior to the transaction,
        will beneficially own, immediately after the transaction, shares entitling
        such
        stockholders to more than 50% of all votes to which all stockholders of the
        parent corporation would be entitled in the election of directors (without
        consideration of the rights of any class of stock to elect directors by a
        separate class vote); or
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  (ii)           upon
        the consummation of (A) a merger or consolidation of the Company with another
        corporation where the stockholders of the Company, immediately prior to the
        merger or consolidation, will beneficially own, immediately after the merger
        or
        consolidation, shares entitling such stockholders to less than 50% of all
        votes
        to which all stockholders of the surviving corporation would be entitled
        in the
        election of directors (without consideration of the rights of any class of
        stock
        to elect directors by a separate class vote) or (B) a sale or other disposition
        of all or substantially all of the assets of the Company.
  In
        the
        event of a Change of Control, the Committee may take such actions as it deems
        appropriate pursuant to the Plan, provided that all payments in settlement
        of
        the Restricted Units pursuant to the Plan shall be made on or within 30 days
        of
        the occurrence of the Change of Control, notwithstanding anything to the
        contrary set forth in Section 15(c) of the Plan.”
  4.  Section
        10 of the Original Agreement is hereby amended and restated in its entirety
        as
        follows:
  “Assignment
        and Transfers.  The rights and interests of the Grantee under this
        Agreement may not be sold, assigned, encumbered or otherwise transferred
        except,
        in the event of the death of the Grantee, by will or by the laws of descent
        and
        distribution.  In the event of any attempt by the Grantee to alienate,
        assign, pledge, hypothecate, or otherwise dispose of the Restricted Units
        or any
        right hereunder, or in the event of the levy or any attachment, execution
        or
        similar process upon the rights or interests hereby conferred, POZEN may
        terminate the Restricted Units by notice to the Grantee, and the Restricted
        Units and all rights hereunder shall thereupon become null and
        void.  The rights and protections of POZEN hereunder shall extend to
        any successors or assigns of POZEN and to POZEN’s parents, subsidiaries, and
        affiliates.  This Agreement may be assigned by POZEN without the
        Grantee’s consent.”
  5.           Except
        as herein amended, the terms and provisions of the Original Agreement shall
        remain in full force and effect as originally executed.
  6.           This
        First Amendment shall be governed by and construed and enforced in accordance
        with the laws of the State of Delaware, without reference to the choice of
        law
        provisions of such laws.
  7.           This
        First Amendment may be executed in any number of counterparts, each of which
        shall constitute one agreement binding on all parties hereto.
  8.            This
        First Amendment and the Original Agreement, as amended and modified by this
        First Amendment, shall constitute and be construed as a single
        agreement.
 
 
 *[Signature
        page follows.]*
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  IN
        WITNESS WHEREOF, POZEN has caused its duly authorized officer to execute
        this
        First Amendment to Restricted Stock Unit Agreement, and the Grantee has placed
        his signature hereon, effective as of the date first written above.
  POZEN
                  INC.By:
              /s/
                William L. HodgesName:
              William
                L. HodgesTitle:
              Sr.
                Vice President & Chief Financial Officer**GRANTEE:**/s/
                  John R. PlachetkaJohn
                  R. Plachetka, Pharm.D.
 
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