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Title:   Author  item
                                            CHOI, SUN PHIL - AJOU UNIVERSITY, KOREAitem
                                            KANG, MI YOUNG - KYUNGPOOK NAT.UNIV. KOREAitem
                                            KOH, HE-JONG - SEOUL NAT.UNIV. KOREAitem
                                            KOZUKUE, NOBVUYUKI - YEUNGNAM UNIV. KOREAitem
                                            NAM, SEOK HYUN - AJOU UNIVERSITY  KOREAitem
                                            Friedman, Mendel
  Submitted to: Food and Chemical Toxicology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/25/2005
                                    Publication  Date: 3/15/2005
                                    Citation: Choi, S., Kang, M., Koh, H., Kozukue, N., Nam, S., Friedman, M. 2005. Bran extracts from pigmented rice seeds inhibit phorbol ester tumor promotion in lymphoblastoid b cells. Food and Chemical Toxicology.43:741-745.Interpretive Summary: As part of an effort designed to discover new, naturally-occurring antimicrobial and antiviral compounds, we participated in a collaborative study carried out in Korea which showed that compared to an extract from the bran of nonpigmented white cooking rice variety Chuchung, the extracts from the pigmented varieties strongly inhibited phorbol ester-induced tumor promotion in marmoset lymphoblastoid cells B95-8 in vitro. The information should be useful for applying the short-term test of anti-tumor-promoting activities of rice bran to other natural products and for evaluating pigmented rice and their biologically active compounds as potnetial antibacterial and antiviral agents against foodborne pathogens.
                                Technical Abstract: Flow cytometry was used for quantitative evaluation of anti-tumor promoting activity by an in vitro short-term assay system measuring inhibition of Epstein-Barr virus early-antigen activation (EBV-EA) induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). This assays simultaneously measures both anti-tumor-promoting activity and cytotoxicity of target substances using the same batch of cells. Using this modified short-term procedure, we determined the anti-tumor promoting activity of 70% ethanol-water extracts of bran (outer layer) from seeds of five pigmented rice cultivars: JumLalocal-1, DZ 78, Elwee, LK1-3-6-12-1-1, and LK1A-2-12-1-1. The results show that compared to an extract from the nonpigmented white cooking rice variety Chuchung, the extracts from the pigmented varieties strongly inhibited phorbol ester-induced tumor promotion in marmoset lymphoblastoid cells B95-8 in vitro. The information should be useful for applying the short-term test of anti-tumor-promoting activities of rice bran to other natural products and for evaluating pigmented rice cultivars as a genetic resource for the development of health-promoting rice varieties.


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