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Title:   Author  item
                                            Kapczynski, Darrell
  Submitted to: American Association of Avian Pathologists
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/2/2004
                                    Publication  Date: 7/28/2004
                                    Citation: Kapczynski, D.R. 2004. Development of a virosome vaccine for protecting turkey poults against subtype c avian metapneumovirus. In:Proceedings of the American Association of Avian Pathologists., July 24-28, 2004, Philadelphia, Pennsylvania. 2004 CDROMInterpretive Summary:
                                Technical Abstract: An avian metapneumovirus (aMPV) virosome vaccine was prepared and tested for protection of turkeys by aMPV challenge.  The vaccine was produced using a detergent-based (Triton X-100) extraction of aMPV subtype C.  Western blot and virus-neutralization analysis confirmed that the aMPV virosomes contained both the fusion (F) and attachment (G) glycoproteins.  SPF turkeys were immunized either intranasally (IN) or intramuscularly (IM) with the aMPV virosome vaccine.  Vaccination decreased clinical signs of disease and viral load in the respiratory tract following virulent challenge. These results demonstrate that immunization of turkeys with aMPV virosomes can be an effective strategy for control of disease.


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