U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            WITHANAGE, G S - OSAKA UNIVERSITY JAPANitem
                                            SASAI, K - OSAKA UNIVERSITY JAPANitem
                                            FUKATA, T - OSAKA UNIVERSITY JAPANitem
                                            MIYAMOTO, T - OSAKA UNIVERSITY JAPANitem
                                            Lillehoj, Hyunitem
                                            BABA, E - OSAKA UNIVERSITY JAPAN
  Submitted to: Avian Pathology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/5/2005
                                    Publication  Date: 5/1/2005
                                    Citation: Withanage, G.K., Sasai, K., Fukata, T., Miyamoto, T., Lillehoj, H.S., Baba, E. 2005. Increased lymphocyte subpopulations and macrophages in the ovaries and oviducts of laying hens infected with salmonella enterica serovar enteritidis. Avian Pathology 32:583-590.Interpretive Summary: The incidence of Salmonella Enteritidis (SE) isolation associated with food poisoning has dramatically increased in many countries. Chickens appear to be the major reservoir of this organism with eggs and poultry products being the most important sources of salmonellosis. Ability to control foos poisoning caused by Salmonella depends upon our ability to understand host immunity to this pathogen and development of novel vaccine. In order to understand how Salmonella contaminates poultry meat, ARS scientists in collaboration with scientists at University of Osaka conducted series of studies to investigate Salmonella contamination of poultry reproductive tracts. The results indicated that the reproductive organs of laying hens are important sites for Salmonella colonization and for egg contamination. In order to develop a strategy to reduce Salmonella contamination of the intact eggs, understanding the local immune responses in the reproductive organs in chickens will be important. Additional studies based upon the results of this study will enhance our understanding of the nature of host protective mechanisms involved against Salmonella and will help poultry industry to better manage salmonellosis.
                                Technical Abstract: Salmonella enterica serovar Enteritidis (SE) is a causative agent for human food poisoning cases throughout the world. The ovaries and the oviducts of the laying hens are the major sites of SE colonization from which vertical transmission to eggs occurs. In this study Salmonella-induced changes in T lymphocytes, B-lymphocytes and macrophages in the ovaries and oviducts were assessed after primary and secondary experimental inoculations of laying hens with SE. Statistically significant increases in the numbers of T cells (both CD4+ and CD8+) and macrophages were observed at 7 to 14 days after primary inoculation followed by a peak in B-cell numbers from the 14th day post-primary inoculation onwards in the secretary areas of the oviducts. The peak in lymphocyte numbers immediately preceded a decline in the rate of SE recovery from the reproductive tract beginning at day 14. The correlation of decreased Salmonella recovery with elevated lymphocyte and macrophage numbers strongly suggests that local cell-mediated immunity is involved in controlling SE infection in the ovaries and oviducts


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov