UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



FORM 20-F



(Mark One)



| ̈  | Registration statement pursuant to Section 12(b) or 12(g) of the Securities
    Exchange Act of 1934.                                                                          
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Or |                                                                                                                                                                                
| ̈  | Annual report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.                                                                                          
|Or |                                                                                                                                                                                
|x  | Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934.
    For the transition period from June 1, 2014 to December 31, 2014 .               
|Or |                                                                                                                                                                                
| ̈  | Shell company report pursuant to Section 13 or 15(d)
        of the Securities Exchange Act of 1934.
        Date of event requiring this shell company report _______________.



Commission file number 001-32001



APTOSE BIOSCIENCES INC.

(Exact Name of Registrant as Specified
in Its Charter)



Canada

(Jurisdiction of Incorporation or Organization)



2 Meridian Road

Toronto, Ontario

M9W 4Z7

Canada

(Address of Principal Executive Offices)



Gregory Chow

Chief Financial Officer

2 Meridian Road

Toronto, Ontario M9W 4Z7

Canada

Telephone: (416) 798-1200

Facsimile: (416) 798-2200

(Name, Telephone, E-mail and/or Facsimile
number and Address of Company Contact Person)

Securities registered or to be registered pursuant to Section
12(b) of the Act: None



|Title of Each
    Class |  | Name of Each Exchange
    On Which Registered
|----------------------- |  | ---------------------------------------------
|Common Shares           |  | The NASDAQ Capital Market                    



Securities registered or to be registered
pursuant to Section 12(g) of the Act: None



Securities for which there is a reporting
obligation pursuant to Section 15(d) of the Act: None



Indicate the number of outstanding shares
of each of the issuer’s classes of capital or common stock as of the close of the period covered by the annual report.













Common Shares, without par value, at December
31, 2014: 11,699,873



Indicate by check mark if the registrant
is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.



Yes  ̈No x



If this is an annual or transition report,
indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Securities Exchange
Act of 1934.



Yes  ̈No x



Indicate by check mark whether the registrant:
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding
12 months (or such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing
requirements for the past 90 days.



Yes xNo  ̈



Indicate by check mark whether the registrant
has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted
and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such
shorter period that the registrant was required to submit and post such files).



Yes  ̈No  ̈



Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and
large accelerated filer” in Rule 12b-2 of the Exchange Act.



Large accelerated
filer  ̈ Accelerated filer  ̈ Non-accelerated
filer x



Indicate by check mark which basis of
accounting the registrant has used to prepare the financial statements included in this filing.



| |  | U.S. GAAP  ̈International
    Financial Reporting Standards as issued by the International Accounting Standards Board xOther  ̈
| |  | -----------------------------------------------------------------------------------------------------------------------------



If “Other” has been checked
in response to the previous question, indicate by check mark which financial statement item the registrant has elected to follow.



Item 17  ̈Item 18  ̈



If this is an annual report, indicate
by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).



Yes  ̈No x











TABLE OF CONTENTS



|          |                                                                              | Page
|--------- | ---------------------------------------------------------------------------- | ----
|          |                                                                              |     
|PART I    |                                                                              | 1   
|          |                                                                              |     
|Item 1.   | Identity of Directors, Senior Management and Advisors                        | 1   
|Item 2.   | Offer Statistics and Expected Timetable                                      | 1   
|Item 3.   | Key Information                                                              | 1   
|Item 4.   | Information on the Company                                                   | 11  
|Item 4A.  | Unresolved Staff Comments                                                    | 27  
|Item 5.   | Operating and Financial Review and Prospects                                 | 28  
|Item 6.   | Directors, Senior Management and Employees                                   | 29  
|Item 7.   | Major Shareholders and Related Party Transactions                            | 44  
|Item 8.   | Financial Information                                                        | 46  
|Item 9.   | The Offer and Listing                                                        | 47  
|Item 10.  | Additional Information                                                       | 48  
|Item 11.  | Qualitative and Quantitative Disclosures about Market Risk                   | 58  
|Item 12.  | Description of Securities Other Than Equity Securities                       | 58  
|          |                                                                              |     
|PART II   |                                                                              | 59  
|          |                                                                              |     
|Item 13.  | Defaults, Dividends, Arrearages and Delinquencies                            | 59  
|Item 14.  | Material Modifications to the Rights of Security Holders and Use of Proceeds | 59  
|Item 15.  | Controls and Procedures                                                      | 59  
|Item 16.  | [Reserved]                                                                   | 60  
|Item 16A. | Audit Committee Financial Expert                                             | 60  
|Item 16B. | Code of Ethics                                                               | 60  
|Item 16C. | Principal Accountant Fees and Services                                       | 60  
|Item 16D. | Exemptions from the Listing Standards for Audit Committees                   | 61  
|Item 16E. | Purchases of Equity Securities by the Issuer and Affiliated Purchasers       | 61  
|          |                                                                              |     
|PART III  |                                                                              | 62  
|          |                                                                              |     
|Item 17.  | Financial Statements                                                         | 62  
|Item 18.  | Financial Statements                                                         | 62  
|Item 19.  | Exhibits                                                                     | 63  



i







GENERAL



On July 10, 2007
(the “Arrangement Date”), the Company completed a plan of arrangement and corporate reorganization with,
among others, 4325231 Canada Inc. (now Global Summit Real Estate Inc.), formerly Lorus Therapeutics Inc. (“Old Lorus”),
6707157 Canada Inc. and Pinnacle International Lands, Inc. (the “Arrangement”). As a result
of the plan of arrangement and reorganization, among other things, each common share of Old Lorus was exchanged for one common
share (“Common Share”) of the Company and the assets (excluding certain deferred tax assets) and liabilities
of Old Lorus (including all of the shares of its subsidiaries) were transferred, directly or indirectly, to the Company and/or
our subsidiaries. We continued the business of Old Lorus after the Arrangement Date with the same officers and employees and continued
to be governed by the same directors as Old Lorus prior to the Arrangement Date.



On August 28, 2014
(the “Name Change Date”), we changed our name from Lorus Therapeutics Inc. to Aptose Biosciences Inc. In this
Transition Report on Form 20-F, all references to “Aptose”, the “Corporation”, the “Company”,
“we”, “our”, “us” and similar expressions, unless otherwise stated, are
references to Old Lorus prior to the Arrangement Date, Lorus Therapeutics Inc. after the Arrangement Date and Aptose Biosciences
Inc. after the Name Change Date. References to this “Form 20-F” and this “Transition Report”
mean references to this Transition Report on Form 20-F for the seven months ended December 31, 2014.



We use the Canadian
dollar as our reporting currency. All references in this Transition Report to “dollars” or “$” are expressed
in Canadian dollars, unless otherwise indicated. See also “Item 3. Key Information” for more detailed currency and
conversion information. Our consolidated financial statements, which form part of this Transition Report, are presented in Canadian
dollars and are prepared in accordance with International Financial Reporting Standards as issued by the International Accounting
Standards Board (“IFRS”), which differ in certain respects from accounting principles generally accepted in
the United States (“U.S. GAAP”).



On October 1, 2014
we consolidated our outstanding Common Shares on the basis of one post-consolidation Common Share for each twelve pre-consolidation
Common Shares. Historical trading prices and volumes disclosed are on a post-consolidated basis and reflect the one for twelve
consolidation.



FORWARD-LOOKING STATEMENTS



This Transition Report contains forward-looking
statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Such statements include,
but are not limited to, statements relating to:



| | · | our business
                                         strategy;
| | - | ---------------------------------------------------------------



| | · | our ability
                                         to obtain the substantial capital we require to fund research and operations;
| | - | ----------------------------------------------------------------------------------------------------------------------------------



| | · | our plans to
                                         secure strategic partnerships to assist in the further development of our product candidates;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our plans to
                                         conduct clinical trials and pre-clinical programs;
| | - | --------------------------------------------------------------------------------------------------------



| | · | our expectations
                                         regarding the progress and the successful and timely completion of the various stages
                                         of our drug discovery, pre- clinical and clinical studies and the regulatory approval
                                         process;
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our plans,
                                         objectives, expectations and intentions; and
| | - | ------------------------------------------------------------------------------------------------



| | · | other statements
                                         including words such as “anticipate”, “contemplate”, “continue”,
                                         “believe”, “plan”, “estimate”, “expect”,
                                         “intend”, “will”, “should”, “may”, and
                                         other similar expressions.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The forward-looking statements
reflect our current views with respect to future events, are subject to risks and uncertainties, and are based upon a number of
estimates and assumptions that, while considered reasonable by us, are inherently subject to significant business, economic, competitive,
political and social uncertainties and contingencies. Many factors could cause our actual results, performance or achievements
to be materially different from any future results, performance, or achievements that may be expressed or implied by such forward-looking
statements, including, among others:



ii







| | · | our ability
                                         to obtain the substantial capital we require to fund research and operations;
| | - | ----------------------------------------------------------------------------------------------------------------------------------



| | · | our lack of
                                         product revenues and history of operating losses;
| | - | ------------------------------------------------------------------------------------------------------



| | · | our early stage
                                         of development, particularly the inherent risks and uncertainties associated with (i) developing
                                         new drug candidates generally, (ii) demonstrating the safety and efficacy of these drug
                                         candidates in clinical studies in humans, and (iii) obtaining regulatory approval to
                                         commercialize these drug candidates;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our drug candidates
                                         require time-consuming and costly preclinical and clinical testing and regulatory approvals
                                         before commercialization;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | clinical studies
                                         and regulatory approvals of our drug candidates are subject to delays, and may not be
                                         completed or granted on expected timetables, if at all, and such delays may increase
                                         our costs and could delay our ability to generate revenue;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | the regulatory
                                         approval process;
| | - | -------------------------------------------------------------------------



| | · | our ability
                                         to recruit patients for clinical trials;
| | - | ---------------------------------------------------------------------------------------------



| | · | the progress
                                         of our clinical trials;
| | - | -----------------------------------------------------------------------------



| | · | our liability
                                         associated with the indemnification of our predecessor and its directors, officers and
                                         employees in respect of an arrangement completed in 2007;
| | - | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our ability
                                         to find and enter into agreements with potential partners;
| | - | ---------------------------------------------------------------------------------------------------------------



| | · | our ability
                                         to attract and retain key personnel;
| | - | -----------------------------------------------------------------------------------------



| | · | our ability
                                         to obtain and maintain patent protection;
| | - | ----------------------------------------------------------------------------------------------



| | · | our ability
                                         to protect our intellectual property rights and not infringe on the intellectual property
                                         rights of others;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our ability
                                         to comply with applicable governmental regulations and standards;
| | - | ----------------------------------------------------------------------------------------------------------------------



| | · | development
                                         or commercialization of similar products by our competitors, many of which are more established
                                         and have or have access to greater financial resources than us;
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | commercialization
                                         limitations imposed by intellectual property rights owned or controlled by third parties;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------



| | · | our business
                                         is subject to potential product liability and other claims;
| | - | -----------------------------------------------------------------------------------------------------------------



| | · | our ability
                                         to maintain adequate insurance at acceptable costs;
| | - | --------------------------------------------------------------------------------------------------------



| | · | further equity
                                         financing may substantially dilute the interests of our shareholders;
| | - | -----------------------------------------------------------------------------------------------------------------------------



| | · | changing market
                                         conditions; and
| | - | ------------------------------------------------------------------------



| | · | other risks
                                         detailed from time-to-time in our on-going quarterly filings, annual information forms,
                                         annual reports and annual filings with Canadian securities regulators and the United
                                         States Securities and Exchange Commission (“SEC”), and those which
                                         are discussed under the heading “Item 3. Key Information—D. Risk Factors”
                                         in this document.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



iii







Should one or more
of these risks or uncertainties materialize, or should the assumptions set out in the section entitled “Item 3. Key Information—D.
Risk Factors” underlying those forward-looking statements prove incorrect, actual results may vary materially from those
described herein. These forward-looking statements are made as of the date of this Transition Report or, in the case of documents
incorporated by reference herein, as of the date of such documents, and we do not intend, and do not assume any obligation, to
update these forward-looking statements, except as required by law. Such statements may not prove to be accurate as actual results
and future events could differ materially from those anticipated in such statements. Investors are cautioned that forward-looking
statements are not guarantees of future performance and accordingly investors are cautioned not to put undue reliance on forward-looking
statements due to the inherent uncertainty therein. New factors emerge from time to time, and it is not possible for management
of the Company to predict all of these factors or to assess in advance the impact of each such factor on the Company’s business
or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained
in any forward-looking statement.



iv







PART I



Item 1.          Identity
of Directors, Senior Management and Advisers



Not applicable.



Item 2.          Offer
Statistics and Expected Timetable



Not applicable.



Item 3.          Key
Information



|A. | Selected financial data.
|-- | ------------------------



The following tables
present our selected consolidated financial data. You should read these tables in conjunction with our audited consolidated financial
statements and accompanying notes included inItem 18of this Transition Report and the “Management’s
Discussion and Analysis of Financial Condition and Results of Operations” included in Item 5 of this Transition Report.



The selected consolidated
financial information set forth below has been derived from the Company's audited consolidated financial statements that are prepared
in accordance with IFRS, which differ in certain respects from the principles the Company would have followed had its consolidated
financial statements been prepared in accordance with U.S. GAAP. The selected audited consolidated financial information should
be read in conjunction with our audited consolidated financial statements and related notes thereto.



Effective July 17,
2014, we changed our fiscal year end from May 31 to December 31. As a result of that change, the current transition period is
for the seven months ended December 31, 2014.



The following table
presents a summary of our consolidated statements of operations derived from our audited consolidated financial statements for
the seven months ended December 31, 2014 and fiscal years ended May 31, 2014, 2013, 2012 and 2011.



Consolidated statements of operations data





|(In thousands, except per share data)                                     |  |                    |        |   |              |   |         |              | 
|------------------------------------------------------------------------- |  | ------------------ | ------ | - | ------------ | - | ------- | ------------ | 
|                                                                          |  | December
 31, 2014 |        |   | May 31, 2014 |   |         | May 31, 2013 | 
|In accordance with IFRS                                                   |  |                    |        |   |              |   |         |              | 
|Revenue                                                                   |  | $                  | —      |   |              | $ | —       |              | 
|Research and development                                                  |  | $                  | 2,404  |   |              | $ | 3,015   |              | 
|General and administrative                                                |  | $                  | 5,588  |   |              | $ | 7,355   |              | 
|Operating expenses                                                        |  | $                  | 7,992  |   |              | $ | 10,370  |              | 
|Finance expense                                                           |  | $                  | 58     |   |              | $ | 259     |              | 
|Finance income                                                            |  | $                  | (279   | ) |              | $ | (76     | )            | 
|Net loss                                                                  |  | $                  | (7,771 | ) |              | $ | (10,553 | )            | 
|Basic and diluted loss per Common Share (post-consolidation)              |  | $                  | (0.67  | ) |              | $ | (2.02   | )            | 
|Weighted average number of Common Shares outstanding (post-consolidation) |  |                    | 11,605 |   |              |   | 5,216   |              | 





The following table
presents a summary of our consolidated balance sheets as at December 31, 2014 and May 31, 2014, 2013, 2012 and 2011. We report
our consolidated financial statements in Canadian (“CDN”) dollars. In this Transition Report, except where
otherwise indicated, all amounts are stated in CDN dollars.



1







Consolidated balance sheet data



|(In thousands, except per share data)                     |  | As at 
    December 
    31 |        |  | As at May 31, |  
|--------------------------------------------------------- |  | --------------------------- | ------ |  | ------------- | -
|                                                          |  | 2014                        |        |  | 2014          |  
|In accordance with IFRS                                   |  |                             |        |  |               |  
|Cash and cash equivalents                                 |  | $                           | 14,365 |  |               | $
|Investments                                               |  | $                           | 16,180 |  |               | $
|Total assets                                              |  | $                           | 31,600 |  |               | $
|Total liabilities                                         |  | $                           | 2,328  |  |               | $
|Total shareholders’ equity (deficit)                      |  | $                           | 29,272 |  |               | $
|Number of Common Shares outstanding (post- consolidation) |  |                             | 11,700 |  |               |  
|Dividends paid on Common Shares                           |  |                             | —      |  |               |  



The following table
sets out the average exchange rates of CDN$1.00 for US$1.00 for the following periods as taken from the Bank of Canada’s
website.



|Period                               |  | Average Close |       
|------------------------------------ |  | ------------- | ------
|Seven Months Ended December 31, 2014 |  |               | 1.1080
|Fiscal Year Ended May 31, 2014       |  |               | 1.0662
|Fiscal Year Ended May 31, 2013       |  |               | 1.0042
|Fiscal Year Ended May 31, 2012       |  |               | 1.0005
|Fiscal Year Ended May 31, 2011       |  |               | 1.0066



The following table
sets forth the high and low exchange rates of CDN$1.00 for US$1.00 for each month during the previous six months.



|Period         |  | High |        |  | Low |  
|-------------- |  | ---- | ------ |  | --- | -
|December 2014  |  | $    | 1.1672 |  |     | $
|November 2014  |  | $    | 1.1452 |  |     | $
|October 2014   |  | $    | 1.1385 |  |     | $
|September 2014 |  | $    | 1.1219 |  |     | $
|August 2014    |  | $    | 1.0985 |  |     | $
|July 2014      |  | $    | 1.0930 |  |     | $



On March 3, 2015, the noon buying rate of CDN$1.00 for US$1.00,
as per the Bank of Canada was CDN$1.00 = US$0.8031.



|B. | Capitalization and indebtedness.
|-- | --------------------------------



| | Not | applicable.
| | --- | -----------



|C. | Reasons for the offer and use of proceeds.
|-- | ------------------------------------------



| | Not | applicable.
| | --- | -----------



|D. | Risk factors.
|-- | -------------



Investing in our securities
involves a high degree of risk. Before making an investment decision with respect to our Common Shares, you should carefully consider
the following risk factors, in addition to the other information included or incorporated by reference in this Transition Report.
Additional risks not currently known by us or that we consider immaterial at the present time may also impair our business, financial
condition, prospects or results of operations. If any of the following risks occur, our business, financial condition, prospects
or results of operations would likely be materially adversely affected. In that case, the trading price of our Common Shares could
decline and you may lose all or part of the money you paid to buy our Common Shares. The risks set out below are not the only
risks and uncertainties we currently face; other risks may arise in the future.



2







RISKS RELATED TO OUR BUSINESS



We are an early stage development
company.



We are at an early
stage of development. In the past five years, none of our potential products has obtained regulatory approval for commercial use
and sale in any country and as such, no significant revenues have resulted from product sales. Significant additional investment
will be necessary to complete the development of any of our product candidates. Preclinical and clinical trial work must be completed
before our potential products could be ready for use within the markets that we have identified. We may fail to develop any products,
obtain regulatory approvals, enter clinical trials or commercialize any products. We do not know whether any of our potential
product development efforts will prove to be effective, meet applicable regulatory standards, obtain the requisite regulatory
approvals, be capable of being manufactured at a reasonable cost or be accepted in the marketplace. We also do not know whether
sales, license fees or related royalties will allow us to recoup any investment we make in the commercialization of our products.



The product candidates
we are currently developing are not expected to be commercially viable for at least the next several years and we may encounter
unforeseen difficulties or delays in commercializing our product candidates. In addition, our potential products may not be effective
or may cause undesirable side effects.



Our product candidates
require significant funding to reach regulatory approval assuming positive clinical results. For example, our lead product candidate
APTO-253, has begun enrolment in a Phase I clinical trial in patients with relapsed or refractory hematologic malignancies. Additional
funding or a partnership may be necessary to complete, if required, a Phase II or Phase III clinical trial. Such funding may be
very difficult, or impossible to raise in the public or private markets or through partnerships. If funding or partnerships are
not attainable, the development of these product candidates may be significantly delayed or stopped altogether. The announcement
of a delay or discontinuation of development would likely have a negative impact on our share price.



We need to raise additional capital.



We have an ongoing
need to raise additional capital. To obtain the necessary capital, we must rely on some or all of the following: additional share
issues, debt issuances (including promissory notes), collaboration agreements or corporate partnerships and grants and tax credits
to provide full or partial funding for our activities. Additional funding may not be available on terms that are acceptable to
us or in amounts that will enable us to carry out our business plan.



Our need for capital
may require us to:



| | · | engage
                                         in equity financings that could result in significant dilution to existing investors;
| | - | -------------------------------------------------------------------------------------------------------------------------------------



| | · | delay
                                         or reduce the scope of or eliminate one or more of our development programs;
| | - | ---------------------------------------------------------------------------------------------------------------------------



| | · | obtain
                                         funds through arrangements with collaborators or others that may require us to relinquish
                                         rights to technologies, product candidates or products that we would otherwise seek to
                                         develop or commercialize ourselves; or
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | license
                                         rights to technologies, product candidates or products on terms that are less favourable
                                         to us than might otherwise be available;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | considerably
                                         reduce operations; or
| | - | ---------------------------------------------------------------------------



| | · | cease
                                         our operations.
| | - | --------------------------------------------------------------



3







We have a history of operating losses.
We expect to incur net losses and we may never achieve or maintain profitability.



We have not been profitable
since our inception in 1986. We reported net losses of $7.8 million in the 7 months ended December 31, 2014 and $10.6 million
and $5.6 million for the fiscal years ended May 31, 2014 and 2013, respectively, and as of December 31, 2014, we had an accumulated
deficit of $218 million.



We have not generated
any significant revenue to date and it is possible that we will never have sufficient product sales revenue to achieve profitability.
We expect to continue to incur losses for at least the next several years as we or our collaborators and licensees pursue clinical
trials and research and development efforts. To become profitable, we, either alone or with our collaborators and licensees, must
successfully develop, manufacture and market our current product candidate APTO-253 as well as continue to identify, develop,
manufacture and market new product candidates. It is possible that we will never have significant product sales revenue or receive
royalties on our licensed product candidates. If funding is insufficient at any time in the future, we may not be able to develop
or commercialize our products, take advantage of business opportunities or respond to competitive pressures.



Clinical trials
are long, expensive and uncertain processes and Health Canada or the United States Food and Drug Administration (“FDA”)
may ultimately not approve any of our product candidates. We may never develop any commercial drugs or other products that generate
revenues.



In the past five years,
none of our product candidates has received regulatory approval for commercial use and sale in North America. We cannot market
a pharmaceutical product in any jurisdiction until it has completed thorough preclinical testing and clinical trials in addition
to that jurisdiction’s extensive regulatory approval process. Approval in one country does not assure approval in another
country. In general, significant research and development and clinical studies are required to demonstrate the safety and effectiveness
of our product candidates before we can submit any regulatory applications.



Clinical trials are
long, expensive and uncertain processes. Clinical trials may not be commenced or completed on schedule and Health Canada or the
FDA or any other regulatory body may not ultimately approve our product candidates for commercial sale. The clinical trials of
any of our drug candidates could be unsuccessful, which would prevent us from advancing, commercializing or partnering the drug.



Even if the results
of our preclinical studies or clinical trials are initially positive, it is possible that we will obtain different results in
the later stages of drug development or that results seen in clinical trials will not continue with longer term treatment. Positive
results in Phase I clinical trials may not be repeated in larger Phase II or Phase III clinical trials.



Our preclinical studies
and clinical trials may not generate positive results that will allow us to move towards the commercial use and sale of our product
candidates. Furthermore, negative preclinical or clinical trial results may cause our business, financial condition, or results
of operations to be materially adversely affected. For example, our lead product candidate APTO-253 has entered a Phase Ib testing
in patients with relapsed or refractory hematologic malignancies for which there is a long development path ahead that will take
many years to complete and is prone to the risks of failure inherent in drug development.



Preparing, submitting
and advancing applications for regulatory approval is complex, expensive and time intensive and entails significant uncertainty.
A commitment of substantial resources to conduct time-consuming research, preclinical studies and clinical trials is required
if we are to complete development of our products.



Later stage clinical
trials of our products require that we identify and enroll a large number of patients with the illness under investigation. We
may not be able to enroll a sufficient number of appropriate patients to complete our clinical trials in a timely manner, particularly
in smaller indications and indications where this is significant competition for patients. If we experience difficulty in enrolling
a sufficient number of patients to conduct our clinical trials, we may need to delay or terminate ongoing clinical trials and
will not accomplish objectives material to our success. Delays in planned patient enrolment or lower than anticipated event rates
in our current clinical trials or future clinical trials also may result in increased costs, program delays, or both.



4







In addition, unacceptable
toxicities or adverse side effects may occur at any time in the course of preclinical studies or human clinical trials or, if
any product candidates are successfully developed and approved for marketing, during commercial use of any approved products.
The appearance of any unacceptable toxicities or adverse side effects could interrupt, limit, delay or abort the development of
any of our product candidates or, if previously approved, necessitate their withdrawal from the market. Furthermore, disease resistance
or other unforeseen factors may limit the effectiveness of our potential products.



Our failure to develop
safe, commercially viable drugs would substantially impair our ability to generate revenues and sustain our operations and would
materially harm our business and adversely affect our share price.



We may not achieve
our projected development goals in the time frames we announce and expect.



We set goals for,
and make public statements regarding, the expected timing of the accomplishment of objectives material to our success, such as
the commencement and completion of clinical trials, the partnership of our product candidates and our ability to secure the financing
necessary to continue the development of our product candidates. The actual timing of these events can vary dramatically due to
factors within and beyond our control, such as delays or failures in our clinical trials, the uncertainties inherent in the regulatory
approval process, market conditions and interest by partners in our product candidates among other things. Our clinical trials
may not be completed, and we may not make regulatory submissions or receive regulatory approvals as planned, or that we will secure
partnerships for any of our product candidates. Any failure to achieve one or more of these milestones as planned would have a
material adverse effect on our business, financial condition and results of operations.



As a result
of intense competition and technological change in the biotechnical and pharmaceutical industries, the marketplace may not accept
our products or product candidates, and we may not be able to compete successfully against other companies in our industry and
achieve profitability.



Many of our competitors have:



| | · | drug
                                         products that have already been approved or are in development, and operate large, well-funded
                                         research and development programs in the biotechnical and pharmaceutical fields;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | substantially
                                         greater financial, technical and management resources, stronger intellectual property
                                         positions and greater manufacturing, marketing and sales capabilities, areas in which
                                         we have limited or no experience; and
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | significantly
                                         greater experience than we do in undertaking preclinical testing and clinical trials
                                         of new or improved pharmaceutical products and obtaining required regulatory approvals.
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Consequently, our
competitors may obtain Health Canada, FDA and other regulatory approvals for product candidates sooner and may be more successful
in manufacturing and marketing their products than we or our collaborators are.



Our competitor’s
existing and future products, therapies and technological approaches will compete directly with the products we seek to develop.
Current and prospective competing products may be more effective than our existing and future products insofar as they may provide
greater therapeutic benefits for a specific problem or may offer easier delivery or comparable performance at a lower cost.



Any product candidate
that we develop and that obtains regulatory approval must then compete for market acceptance and market share. Our products may
not gain market acceptance among physicians, patients, healthcare payers, insurers, the medical community and other stakeholders.
Further, any products we develop may become obsolete before we recover any expenses we incurred in connection with the development
of these products. As a result, we may never achieve profitability.



If we fail to
attract and retain key employees, the development and commercialization of our products may be adversely affected.



5







We depend on the principal
members of our scientific and management staff. If we lose any of these persons, our ability to develop products and become profitable
could suffer. The risk of being unable to retain key personnel may be increased by the fact that we have not executed long-term
employment contracts with our employees, except for our senior executives. Our future success will also depend in large part on
our ability to attract and retain other highly qualified scientific and management personnel. We face competition for personnel
from other companies, academic institutions, government entities and other organizations.



We may be unable
to obtain patents to protect our technologies from other companies with competitive products, and patents of other companies could
prevent us from manufacturing, developing or marketing our products.



Patent protection



The patent positions
of pharmaceutical and biotechnology companies are uncertain and involve complex legal and factual questions. The United States
Patent and Trademark Office and many other patent offices in the world have not established a consistent policy regarding the
breadth of claims that they will allow in biotechnology patents.



Allowable patentable
subject matter and the scope of patent protection obtainable may differ between jurisdictions. If a patent office allows broad
claims, the number and cost of patent interference proceedings in the United States, or analogous proceedings in other jurisdictions
and the risk of infringement litigation may increase. If it allows narrow claims, the risk of infringement may decrease, but the
value of our rights under our patents, licenses and patent applications may also decrease.



The scope of the claims
in a patent application can be significantly modified during prosecution before the patent is issued. Consequently, we cannot
know whether our pending applications will result in the issuance of patents or, if any patents are issued, whether they will
provide us with significant proprietary protection or will be circumvented, invalidated or found to be unenforceable.



Publication of discoveries
in scientific or patent literature often lags behind actual discoveries. Patent applications filed in the United States generally
will be published 18 months after the filing date unless the applicant certifies that the invention will not be the subject of
a foreign patent application. In many other jurisdictions, such as Canada, patent applications are published 18 months from the
priority date. We may not be aware of such literature. Accordingly, we cannot be certain that the named inventors of our products
and processes were the first to invent that product or process or that we were the first to pursue patent coverage for our inventions.



In addition, U.S.
patent laws may change which could prevent or limit us from filing patent applications or patent claims in the United States to
protect our products and technologies or limit the exclusivity periods that are available to patent holders for U.S. patents.
For example, the Leahy-Smith America Invents Act, (the “Leahy-Smith Act”) was signed into law in 2011 and includes
a number of significant changes to U.S. patent law. These include changes to transition from a “first-to-invent” system
to a “first-to-file” system and to the way issued patents are challenged. These changes may favour larger and more
established companies that have more resources to devote to patent application filing and prosecution. It is not clear what, if
any, impact the Leahy-Smith Act will ultimately have on the cost of prosecuting our patent applications in the United States,
our ability to obtain patents in the United States based on our discoveries and our ability to enforce or defend our U.S. issued
patents.



Enforcement of intellectual property
rights



Protection of the
rights revealed in published patent applications can be complex, costly and uncertain. Our commercial success depends in part
on our ability to maintain and enforce our proprietary rights. If third parties engage in activities that infringe our proprietary
rights, our management’s focus will be diverted and we may incur significant costs in asserting our rights. We may not be
successful in asserting our proprietary rights, which could result in our patents being held invalid or a court holding that the
third party is not infringing, either of which would harm our competitive position.



6







Others may design
around our patented technology. We may have to participate in interference proceedings declared by the United States Patent and
Trademark Office, European opposition proceedings, or other analogous proceedings in other parts of the world to determine priority
of invention and the validity of patent rights granted or applied for, which could result in substantial cost and delay, even
if the eventual outcome is favourable to us. Our pending patent applications, even if issued, may not be held valid or enforceable.



Trade secrets



We also rely on trade
secrets, know-how and confidentiality provisions in our agreements with our collaborators, employees and consultants to protect
our intellectual property. However, these and other parties may not comply with the terms of their agreements with us, and we
might be unable to adequately enforce our rights or obtain adequate compensation for the damages caused by unauthorized disclosure
or use of our trade secrets or know how. Our trade secrets or those of our collaborators also may be independently discovered
by others.



Our products
and product candidates may infringe the intellectual property rights of others, or others may infringe on our intellectual property
rights which could increase our costs.



Our success also depends
on avoiding infringement of the proprietary technologies of others. In particular, there may be certain issued patents and patent
applications claiming subject matter which we or our collaborators may be required to license in order to research, develop or
commercialize APTO-253, our lead product candidate. In addition, third parties may assert infringement or other intellectual property
claims against us. An adverse outcome in these proceedings could subject us to significant liabilities to third-parties, require
disputed rights to be licensed from third-parties or require us to cease or modify our use of the technology. If we are required
to license third-party technology, a license under such patents and patent applications may not be available on acceptable terms
or at all. Further, we may incur substantial costs defending ourselves in lawsuits against charges of patent infringement or other
unlawful use of another’s proprietary technology. We may also need to bring claims against others who we believe are infringing
our rights in order to become or remain competitive and successful. Any such claims can be time consuming and expensive to pursue.



If product liability,
clinical trial liability or environmental liability claims are brought against us or we are unable to obtain or maintain product
liability, clinical trial or environmental liability insurance, we may incur substantial liabilities that could reduce our financial
resources.



The clinical testing
and commercial use of pharmaceutical products involves significant exposure to product liability, clinical trial liability, environmental
liability and other risks that are inherent in the testing, manufacturing and marketing of our products. These liabilities, if
realized, could have a material adverse effect on the Company’s business, results of operations and financial condition.



We have obtained limited
product liability insurance coverage for our clinical trials on humans; however, our insurance coverage may be insufficient to
protect us against all product liability damages. Regardless of merit or eventual outcome, liability claims may result in decreased
demand for a future product, injury to reputation, withdrawal of clinical trial volunteers, loss of revenue, costs of litigation,
distraction of management and substantial monetary awards to plaintiffs. Additionally, if we are required to pay a product liability
claim, we may not have sufficient financial resources to complete development or commercialization of any of our product candidates
and our business and results of operations will be adversely affected. In general, insurance will not protect us against some
of our own actions, such as negligence.



As the Company’s
development activities progress towards the commercialization of product candidates, our liability coverage may not be adequate,
and the Company may not be able to obtain adequate product liability insurance coverage at a reasonable cost, if at all. Even
if the Company obtains product liability insurance, its financial position may be materially adversely affected by a product liability
claim. A product liability claim could also significantly harm the Company’s reputation and delay market acceptance of its
product candidates. Additionally, product recalls may be issued at the direction of the FDA, other government agencies or other
companies having regulatory control for pharmaceutical sales. If a product recall occurs in the future, such a recall could adversely
affect our business, financial condition or reputation.



7







We may be unable
to obtain partnerships for our product candidates, which could curtail future development and negatively affect our share price.
In addition, our partners might not satisfy their contractual responsibilities or devote sufficient resources to our partnership.



Our strategy for the
research, development and commercialization of our products requires entering into various arrangements with corporate collaborators,
licensors, licensees and others, and our commercial success is dependent upon these outside parties performing their respective
contractual responsibilities. The amount and timing of resources that such third parties will devote to these activities may not
be within our control. These third parties may not perform their obligations as expected and our collaborators may not devote
adequate resources to our programs. In addition, we could become involved in disputes with our collaborators, which could result
in a delay or termination of the related development programs or result in litigation. We intend to seek additional collaborative
arrangements to develop and commercialize some of our products. We may not be able to negotiate collaborative arrangements on
favourable terms, or at all, in the future, and our current or future collaborative arrangements may not be successful.



If we cannot negotiate
collaboration, licence or partnering agreements, we may never achieve profitability and we may not be able to continue to develop
our product candidates. Phase II and Phase III clinical trials for APTO-253 would require significant amounts of funding and such
funding may not be available to us.



Exchange rate risk



We may be exposed
to fluctuations of the Canadian dollar against certain other currencies because we publish our consolidated financial statements
and hold our investments in Canadian dollars, while we incur many of our expenses in foreign currencies, primarily the United
States dollar. Fluctuations in the value of currencies could cause us to incur currency exchange losses. We do not currently employ
a hedging strategy against exchange rate risk. We cannot assert with any assurance that we will not suffer losses as a result
of unfavorable fluctuations in the exchange rates between the Canadian dollar, the United States dollar and other currencies.



We have agreed
to indemnify our predecessor corporation Old Lorus and its directors, officers and employees.



In connection with
the reorganization that we undertook in July 2007, we have agreed to indemnify our predecessor, Old Lorus, and its directors,
officers and employees from and against all damages, losses, expenses (including fines and penalties), other third party costs
and legal expenses, to which any of them may be subject arising out of any matter occurring:



| | · | prior
                                         to, at or after the effective time of the arrangement transaction, and directly or indirectly
                                         relating to any of the assets of Old Lorus transferred to us pursuant to the arrangement
                                         transaction (including losses for income, sales, excise and other taxes arising in connection
                                         with the transfer of any such asset) or conduct of the business prior to the effective
                                         time of the arrangement;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | prior
                                         to, at or after the effective time as a result of any and all interests, rights, liabilities
                                         and other matters relating to the assets transferred by Old Lorus to us under the arrangement;
                                         and
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | prior
                                         to or at the effective time and directly or indirectly relating to, with certain exceptions,
                                         any of the activities of Old Lorus or the arrangement.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



This indemnification
obligation could result in significant liability to us. To date no amount has been claimed on this indemnification obligation.
Should a claim arise under this indemnification obligation it could result in significant liability to the Company which could
have a negative impact on our liquidity, financial position, and ability to obtain future funding among other things.



We have no manufacturing
capabilities and face supply risks. We depend on third-parties, including a number of sole suppliers, for manufacturing and storage
of our product candidates used in our clinical trials. Product introductions may be delayed or suspended if the manufacture of
our products is interrupted or discontinued.



8







Other than limited
quantities for research purposes, we do not have manufacturing facilities to produce supplies of APTO-253 or any of our other
product candidates to support clinical trials or commercial launch of these products, if they are approved. We are dependent on
third parties for manufacturing and storage of our product candidates. If the supply of necessary components is interrupted, components
from alternative suppliers may not be available in sufficient volumes or at acceptable quality levels within required timeframes,
if at all, to meet the needs of the Company. An inability to contract for a sufficient supply of our product candidates on acceptable
terms, or delays or difficulties in the manufacturing process or our relationships with our manufacturers, may lead to us not
having sufficient product to conduct or complete our clinical trials or support preparations for the commercial launch of our
product candidates, if approved. This may lead to substantial lost revenue opportunity and contract liability to third parties.



Extensive Government Regulation



Government regulation
is a significant factor in the development, production and marketing of the Company’s products. Research and development,
testing, manufacture, marketing and sales of pharmaceutical products or related products are subject to extensive regulatory oversight,
often in multiple jurisdictions, which may cause significant additional costs and/or delays in bringing products to market, and
in turn, may cause significant losses to investors. The regulations applicable to the Company's product candidates may change.
Even if granted, regulatory approvals may include significant limitations on the uses for which products can be marketed or may
be conditioned on the conduct of post-marketing surveillance studies. Failure to comply with applicable regulatory requirements
can, among other things, result in warning letters, the imposition of civil penalties or other monetary payments, delay in approving
or refusal to approve a product candidate, suspension or withdrawal of regulatory approval, product recall or seizure, operating
restrictions, interruptions of clinical trials or manufacturing, injunctions or criminal prosecution. In addition, regulatory
agencies many not approve the labeling claims that are necessary or desirable for the successful commercialization of the Company’s
product candidates.



Requirements for regulatory
approval vary widely from country to country. Whether or not approved in Canada or the United States, regulatory authorities in
other countries must approve a product prior to the commencement of marketing the product in those countries. The time required
to obtain any such approval may be longer or shorter than in Canada or the United States. Approved drugs, as well as their manufacturers,
are subject to continuing and ongoing review, and discovery of problems with these products or the failure to adhere to manufacturing
or quality control requirements may result in regulatory restrictions being imposed.



Risks Related to Our Common Shares



Our share price
has been and is likely to continue to be volatile and an investment in our Common Shares could suffer a decline in value.



You should consider
an investment in our Common Shares as risky and invest only if you can withstand a significant loss and wide fluctuations in the
market value of your investment. We receive only limited attention by securities analysts and frequently experience an imbalance
between supply and demand for our Common Shares. The market price of our Common Shares has been highly volatile and is likely
to continue to be volatile.This leads to a heightened risk of securities litigation pertaining to such volatility.Factors affecting our Common Share price include but are not limited to:



| | · | our
                                         ability to raise additional capital;
| | - | ---------------------------------------------------------------------------------

| | · | the
                                         progress of our clinical trials:
| | - | -----------------------------------------------------------------------------

| | · | our
                                         ability to obtain partners and collaborators to assist with the future development of
                                         our products;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | general
                                         market conditions;
| | - | -------------------------------------------------------------------

| | · | announcements
                                         of technological innovations or new product candidates by us, our collaborators or our
                                         competitors;
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | · | published
                                         reports by securities analysts;
| | - | ----------------------------------------------------------------------------------

| | · | developments
                                         in patent or other intellectual property rights;
| | - | ------------------------------------------------------------------------------------------------------







9







| | · | the
                                         cash and short term investments held by us and our ability to secure future financing;
| | - | -----------------------------------------------------------------------------------------------------------------------------------

| | · | public
                                         concern as to the safety and efficacy of drugs that we and our competitors develop; and
| | - | ---------------------------------------------------------------------------------------------------------------------------------------

| | · | shareholder
                                         interest in our Common Shares.
| | - | -----------------------------------------------------------------------------------



Future
sales of our Common Shares by us or by our existing shareholders could cause our share price to fall.



The issuance of Common
Shares by us could result in significant dilution in the equity interest of existing shareholders and adversely affect the market
price of our Common Shares. Sales by existing shareholders of a large number of our Common Shares in the public market and the
issuance of shares issued in connection with strategic alliances, or the perception that such additional sales could occur, could
cause the market price of our Common Shares to decline and have an undesirable impact on our ability to raise capital.



We are susceptible to stress in
the global economy and therefore, our business may be affected by the current and future global financial condition.



If the increased level
of volatility and market turmoil that have marked recent years continue, our operations, business, financial condition and the
trading price of our Common Shares could be materially adversely affected. Furthermore, general economic conditions may have a
great impact on us, including our ability to raise capital, our commercialization opportunities and our ability to establish and
maintain arrangements with others for research, manufacturing, product development and sales.



An active trading market in our
Common Shares may not be sustained.



Our Common Shares
are listed for trading on the Toronto Stock Exchange (“TSX”) and the NASDAQ Capital Market (“NASDAQ”).
However, an active trading market in our Common Shares on the stock exchanges may not be sustained and we may not be able to maintain
our listings.



It may be difficult for non-Canadian
investors to obtain and enforce judgments against us because of our Canadian incorporation and presence.



We are a corporation
existing under the laws of Canada. Many of our directors and officers, and all of the experts named in this Transition Report
and the documents incorporated by reference into this Transition Report, are residents of Canada, and all or a substantial portion
of their assets, and a substantial portion of our assets, are located outside the United States. Consequently, although we have
appointed an agent for service of process in the United States, it may be difficult for holders of our shares who reside in the
United States to effect service within the United States upon our directors and officers and experts who are not residents of
the United States. It may also be difficult for holders of our shares who reside in the United States to realize in the United
States upon judgments of courts of the United States predicated upon our civil liability and the civil liability of our directors,
officers and experts under the United States federal securities laws. Investors should not assume that Canadian courts (i) would
enforce judgments of United States courts obtained in actions against us or our directors, officers or experts predicated upon
the civil liability provisions of the United States federal securities laws or the securities or “blue sky” laws of
any state within the United States or (ii) would enforce, in original actions, liabilities against us or our directors, officers
or experts predicated upon the United States federal securities laws or any such state securities or “blue sky” laws.
In addition, we have been advised by our Canadian counsel that in normal circumstances, only civil judgments and not other rights
arising from United States securities legislation are enforceable in Canada and that the protections afforded by Canadian securities
laws may not be available to investors in the United States.



We are likely a “passive foreign
investment company” which may have adverse U.S. federal income tax consequences for U.S. shareholders.



U.S. investors in
our Common Shares should be aware that the Company believes it was classified as a passive foreign investment company (“PFIC”)
during the tax year ended December 31, 2014, and based on current business plans and financial expectations, the Company believes
that it will be a PFIC for the current tax year and may be a PFIC in subsequent tax years. If the Company is a PFIC for any year
during a U.S. shareholder’s holding period, then such U.S. shareholder generally will be required to treat any gain realized
upon a disposition of Common Shares, or any so-called “excess distribution” received on its Common Shares, as ordinary
income, and to pay an interest charge on a portion of such gain or distributions, unless the shareholder makes a timely and effective
“qualified electing fund” election (“QEF election”) or a “mark-to-market” election
with respect to the Common Shares. A U.S. shareholder who makes a QEF election generally must report on a current basis its share
of the Company’s net capital gain and ordinary earnings for any year in which the Company is a PFIC, whether or not the
Company distributes any amounts to its shareholders. However, U.S. shareholders should be aware that we do not intend to satisfy
record keeping requirements that apply to a qualified electing fund, and we do not intend to supply U.S. shareholders with information
that such U.S. shareholders require to report under the QEF election rules, in the event that we are a PFIC and a U.S. shareholder
wishes to make a QEF election. Thus, U.S. shareholders should assume that they will not be able to make a QEF election with respect
to their Common Shares. A U.S. shareholder who makes the mark-to-market election generally must include as ordinary income each
year the excess of the fair market value of the Common Shares over the taxpayer’s basis therein. This paragraph is qualified
in its entirety by the discussion below under the heading “Certain United States Federal Income Tax Considerations.”
Each U.S. shareholder should consult its own tax advisor regarding the U.S. federal, U.S. local, and foreign tax consequences
of the PFIC rules and the acquisition, ownership, and disposition of our Common Shares.



10







Item 4.          Information
on the Company



|A. | History and development of the Company.
|-- | ---------------------------------------



Old Lorus was incorporated
under the Business Corporations Act(Ontario) on September 5, 1986 under the name RML Medical Laboratories Inc. On October
28, 1991, RML Medical Laboratories Inc. amalgamated with Mint Gold Resources Ltd., resulting in Old Lorus becoming a reporting
issuer (as defined under applicable securities law) in Ontario, on such date. On August 25, 1992, Old Lorus changed its name to
IMUTEC Corporation. On November 27, 1996, Old Lorus changed its name to Imutec Pharma Inc., and on November 19, 1998, Old Lorus
changed its name to Lorus Therapeutics Inc. On October 1, 2005, Old Lorus continued under the Canada Business Corporations
Act.



On the Arrangement
Date, Old Lorus completed a plan of arrangement and corporate reorganization with, among others, 6650309 Canada Inc. (“New
Lorus”), 6707157 Canada Inc. and Pinnacle International Lands, Inc. As a result of the plan of arrangement and reorganization,
each Common Share of Old Lorus was exchanged for one Common Share of New Lorus. New Lorus continued the business of Old Lorus
after the Arrangement Date with the same officers and employees and continued to be governed by the same board of directors as
Old Lorus prior to the Arrangement Date.



On August 28, 2014,
New Lorus changed its name from Lorus Therapeutics Inc. to Aptose Biosciences Inc. and on October 1, 2014 we consolidated our
outstanding Common Shares on the basis of one post-consolidation Common Share for each twelve pre-consolidation Common Shares.



The address of the
Company’s head and registered office is 2 Meridian Road, Toronto, Ontario, Canada, M9W 4Z7 and our phone number is (416)
798-1200. Our corporate website is www.aptose.com. The contents of the website and items accessible through the website are specifically
not incorporated in this Transition Report by reference.



Aptose has two subsidiaries:
NuChem Pharmaceuticals Inc. (“NuChem”), a company incorporated under the laws of Ontario, Canada, and Aptose
Biosciences U.S. Inc. (“Aptose USA”), a company incorporated under the laws of Delaware, USA. Aptose owns 80%
of the issued and outstanding voting share capital of NuChem and 100% of the issued and outstanding voting share capital of Aptose
USA. NuChem has limited activity and the non-controlling interest is not material to the consolidated financial statements of
the Company. Aptose USA was incorporated in April 2014 and did not have any activity during the seven months ended December 31,
2014.



Our Common Shares
are listed on the TSX under the symbol “APS” and on NASDAQ under the symbol “APTO.”



Aptose is a clinical
stage biotechnology company with a commitment to the development of targeted therapies addressing unmet medical needs in oncology.
We develop therapeutics focused on novel cellular targets at the leading edge of cancer research, coupled with companion diagnostics
to identify the optimal patient population for our products. Our product pipeline includes cancer drug candidates that exert potent
activity as stand-alone agents and that enhance the activities of other anticancer agents without causing overlapping toxicities.
Indeed, we believe our targeted products can emerge as first-in-class or best-in-class agents that deliver single agent benefit
and can serve as the backbone of combination therapies for specific populations of cancer patients.



11







We believe the future
of cancer treatment and management lies in the prospective selection and treatment of patients having malignancies that are genetically
predisposed to response based on a drug’s unique mechanism of action. We are of the view that many drugs currently approved
for the treatment and management of cancer are not selective for the specific genetic alterations (targets) that cause the patient’s
tumor and hence lead to significant toxicities due to off-target effects. Aptose’s strategy is to develop agents that address
a common underlying disease-promoting pathway within a patient population, and we intend to apply this strategy across several
therapeutic indications in oncology, including hematologic malignancies and solid tumor indications. Our lead program, APTO-253,
is a first-in-class inducer of the Krüppel-like factor 4 gene (the “Klf4 Gene”) for patients with advanced
hematologic malignancies, including acute myeloid leukemia (“AML”) and myelodysplastic syndromes (“MDS”).



The following table
sets forth various product conditions in our pipeline and their respective stages of development.







Capital Expenditures and Divestitures



Not applicable.



12







|B. | Business overview.
|-- | ------------------



As noted above, Aptose
is committed to the development of anticancer drugs that target specific processes that underlie a particular life-threatening
malignancy. This targeted approach is intended to impact the disease-causing events in cancer cells without affecting normal processes
within cells. Such an approach requires that we first identify the underlying oncogenic mechanism in particular cancer cells and
then create a therapeutic that selectively impacts that oncogenic mechanism. As described below, an underlying oncogenic process
has been identified as operative in the majority of patients with AML (acute myeloid leukemia), an aggressive cancer of the blood
and bone marrow for which there is a tremendous need for safe and effective anticancer drugs. Aptose has created a small molecule
targeted drug (APTO-253) that selectively impacts that underlying oncogenic process, and the drug is under development as a novel
therapy for AML and the related MDS.



Krüppel-Like Factor 4 & CDX2



Krüppel-like
factors constitute a diverse family of genes (the “Klf Genes”) that act by modifying the expression levels
of other genes that control essential cellular processes such as proliferation, migration, differentiation, cell death and metastasis.
Approximately 17 Klf Genes are known, with an array of roles that include serving as innate tumor suppressors. The Klf Genes give
rise to the production of proteins (the “KLF Proteins”). Structurally, KLF Proteins include DNA binding domains
that allow for the identification and regulation of other genes. Of particular importance, the Krüppel-like factor 4 protein
(the “KLF4 Protein”) is characterized as a master transcription factor that regulates cell identity and
cell fate.



Production of the
KLF4 Protein is influenced by the expression of another gene, an embryonic gene known as Cdx2 (the “Cdx2 Gene”).The
Cdx2 Gene, while not expressed in the bone marrow and blood cells of normal adults, was observed to be active in the malignant
cells in a majority of patients with AML. It was subsequently noted that the protein product of the Cdx2 Gene (“CDX2
Protein”) interacted directly with the Klf4 Gene. It was demonstrated that the CDX2 Protein causes reductions in KLF4
Protein levels by binding and epigenetically silencing the Klf4 Gene (Faber et. al., J Clin Invest. 2013;123(1):299–314).
In subsequent studies from Faber et. al., it was demonstrated that activation of the Cdx2 Gene in normal cells lacking the CDX2
Protein caused decreased KLF4 Protein levels and promoted excessive cellular proliferation (Figure 1, First Bullet) It also was
demonstrated that genetic manipulation to silence the CDX2 Gene in human AML cells resulted in increased levels of the KLF4 Protein
(Figure 1, Second Bullet) and subsequent induction of cellular apoptosis (programmed cell death) in AML cells. Further, in human
AML cells possessing an active Cdx2 Gene, Faber et. al. inserted an active Klf4 Gene to overcome innate KLF4 Protein suppression,
and revealed that increased KLF4 Protein alone could promote apoptosis (Figure 1, Third Bullet). Thus, KLF4 silencing is a key
oncogenic event in AML and merely raising the levels of KLF4 Protein in AML cells can lead to programmed cell death.



Figure 1: Studies Assessing the Role of KLF4 in AML Cells







13







It has been reported
by Faber et. al. that a multitude of genetic abnormalities in bone marrow stem and progenitor cells can culminate in the aberrant
expression of the Cdx2 Gene and lead to decreased Klf4 Gene transcription to yield diminished KLF4 Protein levels. Therefore,
this abnormal CDX2-KLF4 signature was speculated by Faber et. al. to be a potential leukemogenic trigger for approximately 90%
of AML patients. Separately, it was observed by Scholl et. al. in 2007 (J. Clin. Invest. 117:1037–1048 (2007)) that approximately
40% of patients with higher risk MDS possessed increased CDX2 Protein levels, and may represent the portion of the MDS population
progressing to AML. Other opportunities in oncology in which the Klf4 Gene has been implicated to play a role include colorectal,
gastric, cervical, prostate and lung cancers, among others.



APTO-253: Lead Clinical Program



Our lead program is
APTO-253, a small molecule that induces transcription of the Klf4 Gene in in vitro studies and in in vivo pharmacodynamic
studies of human xenograft tumors in mice. APTO-253 was discovered and identified by Aptose scientists based upon the magnitude
of its antiproliferative activity across a multitude of cell lines. In vitro studies conducted at Aptose demonstrated significant
potency with nanomolar IC50 concentrations of APTO-253 in AML cell lines, and ten to 1000 times greater potency against AML cell
lines than against many solid tumor cell lines. In vitro analyses with relevant AML cell lines, including THP1, HL-60 and
Kasumi-1, demonstrated that APTO-253 significantly elevated KLF4 mRNA and KLF4 Protein levels, with the anticipated downstream
increase in cyclin-dependent kinase inhibitor I (p21, a protein that halts the cell cycle and prevents cells from proliferating),
caspase-3 (an enzyme activated during programmed cell death to chop up other proteins), and Annexin-V (used as a marker for the
initiation of programmed cell death), leading to G1 cell cycle arrest and apoptosis (programmed cell death). APTO-253 is administered
as an intravenous infusion in patients. We previously reported initial results from a dose-escalating Phase I clinical study of
APTO-253 in patients with various solid tumors, and in that study we observed evidence of anti-tumor activity as a single agent
at doses that were safe and well tolerated. Our future plans are to advance APTO-253 to a Phase Ib clinical study in relapsed
/ refractory hematologic malignancies, including patients with AML, MDS, multiple myeloma and various lymphomas, based upon the
common underlying, leukemia-causing profile of Klf4 Gene suppression. The development of APTO-253 currently represents the primary
focus of Aptose.



On
July 28, 2014 we announced that the U.S. FDA had completed its review and cleared the Investigational New Drug (“IND”)
application of APTO-253 for the treatment of hematologic malignancies, including AML, high-risk MDS, lymphomas and multiple myeloma.
Clearance of the IND allowed us to initiate a Phase Ib, multi-center, open-label, clinical study of APTO-253 in patients with
relapsed or refractory hematologic malignancies. The Phase Ib trial will evaluate safety, tolerability, pharmacokinetics, pharmacodynamic
responses and efficacy of APTO-253 as a single agent. The trial is expected to enroll 45-60 patients as part of a dose-escalation
program and two separate disease-specific single-agent expansion cohorts.



The
dose escalation study will include two separate arms: one group of up to 15 patients dedicated to AML and high-risk MDS only and
another group of up to 15 patients for lymphomas and multiple myelomas. The two separate arms will allow for a focused look at
AML and high-risk MDS and exploration of the effect of APTO-253 on lymphomas and myelomas. They will also provide patient data
on two times the number of patients during 2015 than would have been possible with only a single arm study.



The
primary objectives of the Phase Ib trial are: (i) to further assess safety on a new and optimized dosing schedule, and (ii) to
identify the recommended dose for APTO-253 for the upcoming Phase Ib single-agent expansion trials which will include one expansion
in AML for up to 15 patients and one expansion in MDS for up to 15 patients, in hematologic malignancies as well as in subsequent
Phase 2 combination trials.



We
plan to monitor patient Krüppel-like factor 4 (“KLF4”) and the product of the embryonic Cdx2 Gene, the
CDX2 Protein levels upon entry into the study, throughout the study, and during a post-treatment period. We will not exclude patients
based on KLF4 or CDX2 status from participating in this first study as we believe this approach may be useful in further validating
our companion diagnostic and observing potential responses among the broader population.



Subsequent to
the seven months ended December 31, 2014, we announced on January 13, 2015 that we had dosed the first patient in the Phase Ib
dose-escalation study. We anticipate providing a potential update on the dose-escalation study during the summer of 2015, completing
enrollment of the Phase Ib dose-escalation study by late-2015 or the first half of 2016, starting the single agent expansion cohort
studies for this study in 2016 and starting Phase 2 combination studies in 2016.



14











Aptose is currently developing
and validating a companion diagnostic for APTO-253. The diagnostics will be designed to assess the extent of genetic expression
of Cdx2 and Klf4 in patients as a potential predictor of response to therapy with APTO-253, as well as assess post-treatment expression
levels as biomarkers of efficacy.



Acute Myeloid Leukemia



AML is a rapidly progressing
cancer of the blood and bone marrow characterized by the uncontrolled proliferation of dysfunctional myeloblasts that do not mature
into healthy blood cells. It is the most common form of acute leukemia in adults. The American Cancer Society estimates there were
approximately 14,590 new cases of AML and approximately 10,370 deaths from AML in the U.S. in 2013 and that there will be approximately
18,860 new cases of AML and approximately 10,460 deaths from AML in the U.S. in 2014.Standard induction therapy with chemotherapy
is successful in many AML patients, but the majority of these patients will relapse with treatment refractory disease. Typical
relapse rates in patients less than, and greater than, 60 years of age are approximately 48% and 71% respectively, as reported
by Datamonitor Healthcare.



Myelodysplastic Syndromes



MDS are a group of blood
and bone marrow disorders. In MDS, stem cells do not mature normally, and the number of blasts (immature cells) and dysplastic
(abnormally developed) cells increases. Also, the number of healthy mature cells decreases, meaning there are fewer normal red
blood cells, white blood cells, and platelets. The numbers of blood cells are often called blood cell counts. Because of the decrease
in healthy cells, people with MDS often have anemia (a lowered blood cell count), and may have neutropenia (a low white blood cell
count) and thrombocytopenia (a low platelet count). Also, the chromosomes (long strands of genes) in the bone marrow cells may
be abnormal. According to the American Cancer Society, there are approximately 13,000 new cases of MDS annually in the US. Additionally,
Datamonitor Healthcare reports median survival in higher risk MDS patients may range between five months and two years. There are
several subtypes of MDS, and some subtypes of MDS may eventually turn into AML.



Solid Tumors



Phase I data with APTO-253
in patients with solid tumors and preclinical data in solid tumor cells, including non-small cell lung cancer (“NSCLC”),
identified an opportunity for APTO-253 in patients possessing cancers with reduced Klf4 Gene expression. Our prior Phase I study
with APTO-253 also revealed a favorable safety profile for APTO-253. Various solid tumors have exhibited suppressed levels of Klf4
Gene in scientific publications, including colorectal, gastric, pancreatic, prostate and cervical cancers, as well as NSCLC. NSCLC
is an indication that we consider to have a large market potential and important unmet need worldwide, in which the Klf4 Gene is
a tumor suppressor that is present in case-matched normal cells but depressed in NSCLC tumor cells. Aptose may in the future evaluate
the clinical utility of APTO-253 in additional studies in a subset of NSCLC patients that may be predisposed to a response with
a therapeutically activating the Klf4 Gene.



In January 2011, Aptose
announced the first patient enrolment in a Phase I dose-escalation study for APTO-253 in patients with advanced or metastatic solid
tumors who are unresponsive to conventional therapy or for which no effective therapy is available. The study was initially being
conducted at Memorial Sloan-Kettering Cancer Center in New York and later added MD Anderson Cancer Center in Houston as a second
site. Objectives of the study included determination or characterization of the safety profile, maximum tolerated dose, and antitumor
activity of APTO-253, as well as pharmacokinetics and a recommended Phase II dose for subsequent clinical trials.



In June 2012, Aptose announced
the addition of MD Anderson Cancer Center as a second site in the then ongoing APTO-253 Phase I clinical trial, under the direction
of Dr. Jennifer Wheler as the principal investigator. In addition, Aptose announced that the study had successfully completed the
accelerated drug dose escalation stage (Stage 1), with further escalation under way in the non-accelerated dose escalation stage
(Stage 2) for the purpose of determining the maximal tolerated dose level and recommended Phase II dose. The addition of a second
site expanded patient availability for enrollment.



15







In January 2013, Aptose
announced that Phase I clinical study of APTO-253 has successfully escalated to the target dose level based on predicted and observed
clinical effects without limitation by toxicity. The success of this study allowed Aptose to initiate a biomarker clinical investigation
to further explore the effects of the drug at relevant doses determined in the clinical trial.



In April 2013, Aptose announced
the presentation of preclinical data at the 2013 Annual Meeting of the American Association for Cancer Research (“AACR”),
held in Washington, DC from April 6, 2013 through April 10, 2013. The poster presentation titled “Utilization of KLF4
as a pharmacodynamic biomarker for in vivo anticancer activity of a novel small molecule drug APTO-253” covered data from
preclinical studies on anticancer activity and tumor biomarker analysis for APTO-253 in animal models of human NSCLC. The studies
demonstrate that APTO-253 has antitumor activity with a dose-response effect in NSCLC that is associated with a dose dependent
increase of the KLF4 gene.



In July 2013, Aptose announced
the results of the Phase I clinical trial of APTO-253. In this first-in-man, dose-escalation clinical study, APTO-253 demonstrated
a favorable safety profile, as well as encouraging signs of antitumor activity. The design of this trial consisted of APTO-253
as a single agent in patients with advanced solid tumors resistant to multiple standard therapies. The study enrolled 27 patients,
all of which had failed a median of four prior chemotherapies. Although this was primarily a dose-escalation safety study, efficacy
and pharmacokinetics were also explored.



The clinical trial enrolled
patients at seven dose levels ranging from 20 to 229 mg/m2. Of the 27 patients enrolled, 17 were evaluable for efficacy. Of these
17 patients, seven (41%) achieved stable disease by Response Evaluation Criteria In Solid Tumors (“RECIST”).
This included patients with colorectal, lung, appendiceal, liver and uterine cancers. Dose related activity was demonstrated at
the higher dose levels (176 and 229 mg/m2). At these two highest dose levels, four of five evaluable patients (80%) achieved sustained
stable disease by RECIST ranging from 5.6 months to 8 months, representative of disease control. Of these, a patient with
non-small cell lung cancer at the highest dose level additionally demonstrated non-index tumor shrinkage.



The safety assessment indicated
that APTO-253 was well tolerated at all dose levels tested in this trial. The dose escalation was not limited by toxicity. The
most common adverse event was Grade 1 or 2 fatigue seen in three patients. There was one Grade 3 toxicity, asymptomatic low blood
phosphate level that was reversible by supplementation with phosphates. The pharmacokinetic profile was consistent with the predictive
profile seen preclinically, and the elimination profile and half-life in patients were suggestive of a very rapid distribution
phase and prolonged retention.



Small Molecular
Program



In April 2013, Aptose entered
into a research and license option agreement with Elanco, the animal health division of Eli Lilly and Company (“Elanco”),
to investigate a new proprietary series of Aptose compounds for veterinary medicine. Pursuant to the agreement, Elanco will fund
the research program and was granted an exclusive option to license the worldwide rights to selected compounds for veterinary use;
the terms of which will be negotiated if the option is exercised by Elanco. Aptose retains the rights to develop and commercialize
these compounds for human use. Lead optimization is underway and the next goal is to identify a clinical drug candidate.



APTO-500



This program aims to discover
and develop potent, first-in-class small molecule inhibitors of maternal embryonic leucine zipper kinase (“MELK”).
MELK plays an important role in cancer cell cycle, signaling pathways, and cancer stem cells. MELK is highly expressed in several
cancer types and its expression correlates with poor prognosis in glioma and breast cancer. These findings provide strong support
that selective targeting of MELK may be an effective cancer treatment strategy. Several compounds targeting MELK have been identified.
Cancer associated kinases as drug targets are a very active area for research and development globally and kinase inhibitors are
some of the best selling drugs in oncology, which include Imatinib, Sunitinib, Sorafenib and Erlotinib, whose annual global sales
amount to billions. Much of the current focus is on the development of selective kinase inhibitors that hit specific targets in
cancer cells and cause less toxicity associated with off-target effect. Aptose believes that the APTO-500 program can produce one
of the first selective MELK inhibitor in development for cancer treatment and the market potential for this novel drug could exceed
$1 billion annually. The APTO-500 program is in the discovery phase of development at the present time.



16







Large Molecule Program



The Company’s large
molecule program includes a molecule to target specific cell-surface receptors expressed in certain cancers expressing the Interleukin-17E
receptor (IL-17ER).  The molecule under development is IL-17E, which binds to IL-17ER to lead to targeted cell killing. 
 IL-17E is also known to have activity in stimulating the anti-cancer properties of the immune system.  IL-17E is a protein-based
therapeutic in the pre-clinical stage of development.  The Company is not currently developing IL-17E and is seeking to out-license
the program.



In May 2012, Aptose entered
into a global license with Genentech, a member of the Roche Group, in respect of certain patents owned by Genentech for IL-17E.
Through this license, Genentech granted to Aptose the rights to develop IL-17E as a treatment for a large number of cancers on
a global basis.



In June 2012, the Canadian
Intellectual Property Office issued Aptose’s patent for IL-17E which protects the use of IL-17E to treat cancer, including
many different solid tumors such as colon, breast, ovarian, pancreatic, and lung cancers as well as melanoma, until 2026.



In August 2012, the National
Research Council of Canada Industrial Research Assistance Program (“NRC-IRAP”) awarded funding to Aptose to
support development of IL-17E for cancer therapy. The $50,000 non-repayable contribution from NRC-IRAP was used for a pilot development
project to manufacture IL-17E, which was carried out by researchers at the National Research Council who have extensive experience
in the development, recovery and purification of recombinant proteins and peptides produced by different expression systems.



In December 2012, Aptose
presented new data at the 2012 American Association for Cancer Research (“AACR”) Tumor Immunology: Multidisciplinary
Science Driving Basic and Clinical Advances Conference. The presentation provided an overview of recent preclinical studies conducted
by Aptose to assess the anticancer activity and safety of IL-17E. The studies show that IL-17E significantly inhibits the growth
of colon and melanoma cancers in animal models, with no apparent signs of toxicity. The animal models used provide both a more
complete assessment of the safety of IL-17E, and confirmation of the efficacy of IL-17E in animal models at safe doses. This is
essential information for Aptose’s strategy to bring IL-17E into clinical studies to treat human cancers.



In January 2013, the United
States Patent and Trademark Office issued Aptose the U.S. patent protecting methods of treating cancer with IL-17E, both alone
and in combination with anticancer therapy drugs including gemcitabine, paclitaxel, docetaxel, erlotinib, cisplatin, and bevacizumab.
The patent covers the treatment of a wide range of cancers, including breast, lung, colon, pancreatic, gastric and ovarian tumors,
as well as melanoma. Patents with similar protection for IL-17E are pending in Canada and Europe.



IL-17E is not currently
being developed by Aptose as we are primarily focusing on APTO-253 at the present time.



Business OF THE COMPANY



Strategic Review
Process



On September 12, 2013,
the Company formed a special committee composed of independent directors to review strategic alternatives available to the Company
and secure the long-term financial and operational sustainability of the Company with a view to enhance shareholder value (the
“Special Committee”). On October 28, 2013, the Special Committee, after having considered and reviewed a number
of options, concluded its review. The Special Committee recommended that the board of directors of Aptose (the “Board”)
approve the appointments of William G. Rice, Ph.D. as Chief Executive Officer and Chairman of the Board and of Daniel D. Von Hoff,
M.D., to serve as a special advisor to fulfill the functions of the Company’s Senior Vice President of Medical Affairs. Additionally,
on October 29, 2013, Brian Druker, M.D. was appointed as the Chair of the Company’s newly formed Scientific Advisory Board.



17







Changes in Management



On October 28, 2013, William
G. Rice, Ph.D., was appointed as Chief Executive Officer and Chairman of the Board while Dr. Aiping Young continued as President
and Chief Operating Officer of the Company until she departed the Company on March 18, 2014. Aptose also appointed Daniel D. Von
Hoff, M.D., to serve as a special advisor to fulfill the functions of the Company’s Senior Vice President of Medical Affairs.
Dr. Von Hoff is an independent contractor and advisor but is not an employee of Aptose. The Board, after receiving the recommendation
of the Special Committee, unanimously approved the appointments. In doing so, the Board determined that such appointments were
in the best interest of Aptose, as they were considered to enhance the management team and advisory team with the addition of two
seasoned and experienced biotechnology executives bringing extensive clinical development and capital raising experience and improving
the awareness and presence of the Company in the United States. On April 10, 2014, Dr. Rice was additionally appointed as President
of the Company.



On October 29, 2013, Brian
Druker, M.D., was appointed as the Chair of the Company’s Scientific Advisory Board. Like Dr. Von Hoff, Dr. Druker is an
independent contractor and advisor but not an employee of Aptose.



On December 2, 2013, Avanish
Vellanki was appointed as Chief Business Officer of the Company, to manage global business development, licensing and corporate
strategy, and Gregory K. Chow was appointed as Chief Financial Officer, with responsibility for corporate finance and accounting
functions for the Company. On April 10, 2014, Messrs. Vellanki and Chow were additionally appointed as Senior Vice Presidents of
the Company.



On September 8, 2014, Stephen
B. Howell was appointed Chief Medical Officer of the Company.



Name and year
end change



On September 2, 2014, we
announced that we had changed our name to Aptose Biosciences Inc. from the previous name of Lorus Therapeutics Inc. The new name
reflects our new focus and clinical-stage pipeline strategy, as an oncology research and development organization advancing new
therapeutics and molecular diagnostics based on insights into the genetic profiles of certain cancers and patient populations. 
Our lead product, APTO-253 (formerly LOR-253) exerts its antitumor effects by activating a key apoptotic pathway in tumor cells.
The term "apoptosis" represents the innate self-killing capacity of cells triggered upon the onset of cellular damage,
and cancer cells employ various mechanisms to avoid apoptosis. For these reasons, "apoptosis" is the intuitive root of
the name of "Aptose Biosciences." In addition, our stated goal with respect to the name change is to align the product
portfolio and product development with the strategic course set by its new management team.



Effective July 17, 2014,
we changed our fiscal year end from May 31 to December 31. As a result of that change the current period is for the seven months
ended December 31, 2014 while the prior year comparative period is for the twelve months ended May 31, 2014 and therefore not directly
comparable to the current seven month period.



Reverse Stock
Split



On October 1, 2014, Aptose
filed articles of amendment to give effect to the reverse stock split (consolidation) of its Common Shares on the basis of one
post-consolidation Common Share for each 12 pre-consolidation Common Shares (the “Reverse Stock Split”). The
number of Common Shares outstanding as of the time of the announcement was 139,324,451. The number of Common Shares outstanding
immediately following the Reverse Stock Split was 11,610,402.



18







NASDAQ
listing



On October 21, 2014,
Aptose announced that its Common Shares were approved for listing on NASDAQ under the symbol “APTO” and began trading
on NASDAQ on October 23, 2014. Aptose has retained its listing on the TSX under the symbol “APS”.



Financial Strategy



To meet our future financing
requirements, we intend to finance our operations through some or all of the following methods: public or private equity financings,
collaborative and licensing agreements. We intend to pursue financing opportunities as they arise. See “Item 3. Key Information—D.
Risk Factors” above.



April 2014 Public Offering



In April 2014, we completed
a public offering in Canada and a simultaneous private placement in the United States of Common Shares. Aptose issued 4,708,334
(56,500,000 pre-consolidation) Common Shares at a purchase price of $6.00 ($0.50 pre-consolidation) per Common Share including
541,667 (6,500,000 pre-consolidation) Common Shares pursuant to the partial exercise of an over-allotment option, for aggregate
gross proceeds of $28,250,000. The total costs associated with the transaction were approximately $2,665,914 which includes a cash
commission of $1,977,500 based on 7% of the gross proceeds received as part of the offering.



Mr. Sheldon Inwentash and
his joint actors (“Mr. Inwentash”), a former related party of Aptose by virtue of exercising control or direction
over more than 10% of the Common Shares of Aptose, participated in this offering and acquired an aggregate of 108,333 (1,300,000
pre-consolidation) Common Shares.



December 2013 Public Offering



On December 10, 2013, we
completed a public offering of Common Shares. Aptose issued a total of 1,060,833 (12,730,000 pre-consolidation) Common Shares at
a price of $6.60 ($0.55 pre-consolidation) per Common Share, for aggregate gross proceeds of $7,001,500 from this offering.



The total costs associated
with the transaction were approximately $999,440 which includes a cash commission of $420,090 based on 6% of the gross proceeds
received as part of the offering, and the issuance of 73,198 (878,370 pre-consolidation) broker warrants with an estimated fair
value of $349,592 using the Black-Scholes model. Each broker warrant is exercisable into one Common Share of the Company at a price
of $6.60 ($0.55 pre-consolidation) for a period of twenty four months following closing of the offering.



Mr. Inwentash, a former
related party of the Company by virtue of exercising control or direction over more than 10% of the Common Shares of the Company
participated in this offering and acquired an aggregate of 151,667 (1,820,000 pre-consolidation) Common Shares.



On January 8, 2014, the
underwriters conducting the offering exercised in full their over-allotment option to purchase an additional 159,125 (1,909,500
pre-consolidation) Common Shares of the Company at a price of $6.60 ($0.55 pre-consolidation) per Common Share for additional gross
proceeds of $1,050,225. The total costs associated with the exercise of the over-allotment option were approximately $125,612 based
on 6% of the gross proceeds received as part of the exercise of the over-allotment option, and the issuance of 9,548 (114,570 pre-consolidation)
broker warrants with an estimated fair value of $45,599 using the Black-Scholes model. Each broker warrant is exercisable into
one Common Share of the Company at a price of $6.60 ($0.55 pre-consolidation) for a period of twenty four months following the
closing of the over-allotment option exercise.



Fiscal 2014 Warrant Exercises



During the seven months
ended December 31, 2014, 1,231,000 Common Share purchase warrants were exercised for proceeds of $6,648,000.



19







|Warrants exercised during the seven months ended December 31, 2014: |  |        |       |  |          |  
|------------------------------------------------------------------- |  | ------ | ----- |  | -------- | -
|(in thousands)                                                      |  | Number |       |  | Proceeds |  
|                                                                    |  |        |       |  |          |  
|August 2011 warrants (i)                                            |  |        | 8     |  |          | $
|June 2013 private placement warrants (ii)                           |  |        | 1,223 |  |          | $
|Total                                                               |  |        | 1,231 |  |          | $



|Summary of outstanding warrants:              |  |  |  |  |        | 
|--------------------------------------------- |  |  |  |  | ------ | 
|(in thousands)                                |  |  |  |  | Number | 
|                                              |  |  |  |  |        | 
|August 2011 warrants (i)                      |  |  |  |  |        | 
|June 2013 private placement warrants (ii)     |  |  |  |  |        | 
|December 2013 broker warrants (iii)           |  |  |  |  |        | 
|Number of warrants outstanding, end of period |  |  |  |  |        | 



| | (i) | August 2011 warrants are exercisable into Common Share of Aptose at a price per share of $5.40 ($0.45 pre-consolidation) and expire in August 2016. During the seven months ended December 31, 2014, 8,749 warrants were exercised. In August 2013, 16,126 broker warrants associated with this transaction expired unexercised.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (ii) | June 2013 private placement warrants are exercisable into Common Shares of Aptose at a price per share of $3.00 ($0.25 pre-consolidation) and expire in June 2015.
| | ---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (iii) | December 2013 broker warrants are exercisable into Common Shares of Aptose at a price per share of $6.60 ($0.55 pre-consolidation) and expire in December 2015.
| | ----- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



June 2013 Promissory Notes and Warrants



In June 2013, we completed
a private placement of units at a price of $1,000 per unit, for aggregate gross proceeds of $918,000. Each unit consisted of (i) a
$1,000 principal amount of unsecured promissory note and (ii) 1,000 Common Share purchase warrants. The promissory notes bore
interest at a rate of 10% per annum, payable monthly and were due June 19, 2014. Each warrant entitled the holder to purchase one
Common Share of Aptose at a price per Common Share equal to $3.00 ($0.25 pre-consolidation) at any time until June 19, 2015.



Certain related parties
participated in the transaction. Directors and officers (including Dr. Aiping Young, Dr. Jim Wright and Dr. Mark Vincent) acquired
an aggregate of $68,000 of the promissory notes. Mr. Inwentash acquired $100,000 of the promissory notes. These notes and any interest
accrued thereon were repaid in full in April 2014.



September 2013 Convertible Promissory
Notes



In September 2013, we completed
a private placement of convertible promissory notes for aggregate gross proceeds of $600,000. Each convertible promissory note
consists of a $1,000 principal amount of unsecured promissory note convertible into Common Shares of the Company at a price per
share of $3.60 ($0.30 pre-consolidation). The promissory notes bear interest at a rate of 10% per annum, payable quarterly and
are due September 26, 2015. Mr. Inwentash acquired $150,000 of the promissory notes.



At December 31, 2014, $162,500
of the convertible promissory notes had been converted into Common Shares of the Company.



September 2013 Loans payable



In September 2013, we entered
into loan agreements for proceeds of $150,000. The loan agreements were unsecured, bore interest at a rate of 10% per annum payable
quarterly and were due September 30, 2015. We repaid the loans and all accrued and unpaid interest thereon on April 25, 2014.



20







June 2012 Private Placement



In June 2012, we completed
a private placement of 1,718,750 (20,625,000 pre-consolidation) units at a subscription price of $3.84 ($0.32 pre-consolidation)
per unit and each unit consisted of one Common Share and one Common Share purchase warrant for gross proceeds to Aptose of $6,600,000.
Each warrant was exercisable for a period of 24 months from the date of issuance at an exercise price of $5.40 ($0.45 pre-consolidation).
We paid a cash finder’s fee of $396,000 based on 6% of the gross proceeds of the private placement and issued 103,125 (1,237,500
pre-consolidation) finder’s warrants at an exercise price of $3.84 ($0.32 pre-consolidation) each. Each finder’s warrant
was exercisable into units consisting of 103,125 (1,237,500 pre-consolidation) Common Shares and 103,125 (1,237,500 pre-consolidation)
warrants.



August 2011 Unit Offering



In August 2011, we closed
a public offering for gross proceeds of $2,193,600 whereby we issued 457,000 (5,484,000 pre-consolidation) Common Shares and 473,126
(5,677,515 pre-consolidation) warrants including broker warrants. Each warrant entitles the holder to purchase one Common Share
for five years after the closing of the offering at an exercise price of $5.40 ($0.45 pre-consolidation). If on any date the 10-day
volume weighted average trading price of the Common Shares on the TSX equals or exceeds 200% of the $5.40 ($0.45 pre-consolidation)
exercise price, then upon sending the holders of warrants written notice of and issuing a news release announcing such accelerated
exercise date, the warrants shall only be exercisable for a period of 30 days following the date of notice.



Agreements



Manufacturing Agreements



We currently
rely upon Contract Manufacturing Organizations (CMO’s) for the manufacture of our drug candidates. The
CMO’s manufacture clinical material according to current Good Manufacturing Practices, (GMPs,). Prior to manufacturing,
the CMO’s are approved by our quality assurance department staff, after having conducted audits to ensure such
manufacturers meet the requirements of the relevant regulatory authorities.



Manufactured product for
clinical purposes is tested for conformance with product specifications prior to release. GMP batches
of our drug candidates are subjected to prospectively designed stability test protocols.



License Agreements



Genentech
Inc.



The Company holds a non-exclusive
license from Genentech Inc. (“Genentech”) to certain patent rights to develop and sub-license a specified polypeptide.
In consideration of the license, the Company paid an upfront amount and could be required to pay to Genentech additional milestones
and royalties on sales. The initial amount paid upfront was a one-time non-creditable, non-refundable fee which was immaterial
to the Company. The aggregate milestone amounts payable under the agreement total $2,325,000. Additionally, the Company is obligated
to make royalty payments after the first commercial sale of the polypeptide within a range of 1% to 5% on a country by country
basis on an aggregate worldwide scale of net sales. No milestone or royalty payments under this agreement have become due and the
Company does not expect to make any milestone or royalty payments under this agreement during the fiscal year ending December 31,
2015. The Company cannot reasonably predict when such royalties will become payable, if at all. The agreement will terminate upon
the expiration of the last patent, which is expected to be in 2020. The agreement may be terminated (i) by the Company for any
reason upon 60 days prior written notice to Genentech or (ii) by Genentech for any material breach of the agreement by the Company,
provided that the Company has the option to cure such breach within 30 days following written notice by Genentech.



21







Collaboration Agreements



Elanco



In April 2013, Aptose entered
into a research and license option agreement with Elanco, the animal health division of Eli Lilly and Company, to investigate a
new proprietary series of Aptose’s compounds for veterinary medicine. Pursuant to the agreement, Elanco agreed to fund the
research program and was granted an exclusive option to license from Aptose our worldwide rights for selected compounds for veterinary
use; the terms of which will be negotiated if the option is exercised by Elanco. Aptose retains the rights to develop and commercialize
these compounds for human use and intends to use the animal data from the collaboration as a basis for a partnership with a third
party to develop the technology for the treatment of patients with cancer. Lead optimization is underway and the next goal is to
identify a clinical drug candidate that can be developed for both human and animal use.



Other



From time to time, we enter
into other research and technology agreements with third parties under which research is conducted and monies expended. These agreements
outline the responsibilities of each participant and the appropriate arrangements in the event the research produces a product
candidate.



Deferred Share Unit Plan



As at December 31, 2014,
no deferred share units under the deferred share unit plan of the Company (the “DSU Plan”) were outstanding
(May 31, 2014 – nil).



Intellectual Property and Protection
of Confidential Information and Technology



We believe that our issued
patents and pending applications are important in establishing and maintaining a competitive position with respect to our products
and technology.



Small Molecule



We have been issued 21
patents and have 10 pending patents worldwide for our in-house small molecules.  These patents cover APTO-253 composition
of matter and methods of treating different cancers with APTO-253, including solid tumors and leukemia.   Composition
of matter patents expire in 2028 in the United States and 2026 in other countries.  Our patents also include several compounds
that are similar to APTO-253, which provide protection from competitors seeking to develop anticancer products that are related
in chemical structure to APTO-253.



Large Molecule



We have three issued patents
for our IL-17E immunotherapy program. The patents, which expire in 2026, cover methods of treating cancer with IL-17E.  Specific
cancers listed in the patents include colon, breast, ovarian, cervical, lung gastric and prostate tumors.  Aptose has entered
into a license agreement with Genentech, which provides Aptose the right to use Genentech’s IL-17E composition of matter
patent for anticancer uses, as described above under License Agreements.



Risks Relating to Intellectual Property



Our pending patent applications
may not result in issued patents and our issued patents may not be held valid and enforceable if challenged. Competitors may be
able to circumvent any such issued patents by adoption of a competitive, though non-infringing product or process. Interpretation
and evaluation of pharmaceutical or biotechnology patent claims present complex and often novel legal and factual questions. Our
business could be adversely affected by increased competition in the event that any patent granted to it is held to be invalid
or unenforceable or is inadequate in scope to protect our operations.



While we believe that our
products and technology do not infringe proprietary rights of others, third parties may assert infringement claims in the future
and such claims could be successful. Even if challenges are unsuccessful, we could incur substantial costs in defending ourselves
against patent infringement claims brought by others or in prosecuting suits against others. In addition, others may obtain patents
that we would need to license, which may not be available to us on reasonable terms. Whether we are able to obtain a necessary
license would depend on the terms offered, the degree of risk of infringement and the need for the patent.



22







Until such time, if ever,
that further patents are issued to us, we will rely upon the law of trade secrets to the extent possible given the publication
requirements under international patent treaty laws and/or requirements under foreign patent laws to protect our technology and
our products incorporating the technology. In this regard, we have adopted certain confidentiality procedures. These include: limiting
access to confidential information to certain key personnel; requiring all directors, officers, employees and consultants and others
who may have access to our intellectual property to enter into confidentiality agreements which prohibit the use of or disclosure
of confidential information to third parties; and implementing physical security measures designed to restrict access to such confidential
information and products. Our ability to maintain the confidentiality of our technology is crucial to our ultimate possible commercial
success. The procedures adopted by us to protect the confidentiality of our technology may not be effective, third parties may
gain access to our trade secrets or disclose our confidential technology. Further, by seeking patent protection in various countries,
it is inevitable that a substantial portion of our technology will become available to our competitors, through publication of
such patent applications.



Regulatory Strategy



Our overall regulatory
strategy is to work with the appropriate government departments which regulate the use and sale of therapeutic drug products. This
includes Health Canada in Canada, the Food and Drug Administration in the United States, the European Medicines Agency in Europe,
and other local regulatory agencies with oversight of preclinical studies, clinical trials and marketing of therapeutic products.
Where possible, we intend to take advantage of opportunities for accelerated development of drugs designed to treat rare and serious
or life-threatening diseases. We also intend to pursue priority evaluation of any application for marketing approval filed in Canada,
the United States or the European Union and to file additional drug applications in other markets where commercial opportunities
exist. We may not be able to pursue these opportunities successfully.



Revenues



The Company has not earned
substantial revenues from its drug candidates and is therefore considered to be in the development stage.



Employees



As at December 31, 2014,
we employed 18 full-time persons and 3 part-time persons in research and drug development and administration activities. Among
our employees, 2 hold Ph.D.’s, 1 holds a DVM degree and numerous others hold degrees and designations such as MSc, BSc,
CPA (CA), CPA (California) and MBA. To encourage a focus on achieving long-term performance, employees and members of the Board
have the ability to acquire an ownership interest in the Company through Aptose’s share option and alternate compensation
plans. See Item 6.B – Compensation.



None of our employees are
unionized, and we consider our relations with our employees to be good.



Office Facilities



Our head office, which
occupies 20,500 square feet, is located at 2 Meridian Road, Toronto, Ontario. The leased premises include approximately 8,000 square
feet of laboratory and research space. Our current lease expires on March 31, 2015 and we entered into a lease for new office facilities
in Toronto as described below.



We entered into a lease
agreement for office space, located at 12770 High Bluffs Drive, San Diego, California which occupies approximately 2,204 square
feet. This leased premise is used for administrative purposes only. This lease expires in January 2020.



In January 2015, the Company
entered into a two year lease for laboratory facility space in San Diego and in February 2015 the Company entered into a five year
lease facility in Toronto for office space and a one year agreement for laboratory space. The combined annual cost for these new
locations is expected to be $300 thousand per year.



23







Competition



The biotechnology and pharmaceutical
industries are characterized by rapidly evolving technology and intense competition. There are numerous companies in these industries
that are focusing their efforts on activities similar to ours. Some of these are companies with established positions in the pharmaceutical
industry and may have substantially more financial and technical resources, more extensive research and development capabilities,
and greater marketing, distribution, production and human resources than Aptose. In addition, we face competition from other companies
for opportunities to enter into partnerships with biotechnology and pharmaceutical companies and academic institutions.



Competition with our potential
products may include chemotherapeutic agents, monoclonal antibodies, antisense therapies, small molecules, immunotherapies, vaccines
and other biologics with novel mechanisms of action. These drugs may kill cancer cells indiscriminately, or through a targeted
approach, and some have the potential to be used in non-cancer indications. We also expect that we will experience competition
from established and emerging pharmaceutical and biotechnology companies that have other forms of treatment for the cancers that
we target, including drugs currently in development for the treatment of cancer that employ a number of novel approaches for attacking
these cancer targets. Cancer is a complex disease with more than 100 indications requiring drugs for treatment. The drugs in competition
with our potential drugs have specific targets for attacking the disease, targets which are not necessarily the same as ours. These
competitive drugs, however, could potentially also be used together in combination therapies with our drugs to manage the disease.
Other factors that could render our potential products less competitive may include the stage of development, where competitors’
products may achieve earlier commercialization, as well as superior patent protection, better safety profiles, or a preferred cost-benefit
profile.



Government Regulation



Overview



Regulation by government
authorities in Canada, the United States, and the European Union is a significant factor in our current research and drug development
activities. To clinically test, manufacture and market drug products for therapeutic use, we must satisfy the rigorous mandatory
procedures and standards established by the regulatory agencies in the countries in which we currently operate or intend to operate.



The laws of most of these
countries require the licensing of manufacturing facilities, carefully controlled research and the extensive testing of products.
Biotechnology companies must establish the safety and efficacy of their new products in clinical trials; they must establish current
GMP(s) and control over marketing activities before being allowed to market a product. The safety and efficacy of a new drug must
be shown through human clinical trials of the drug carried out in accordance with the mandatory procedures and standards established
by regulatory agencies.



The process of completing
clinical trials and obtaining regulatory approval for a new drug takes a number of years and requires the expenditure of substantial
resources. Once a new drug or product license application is submitted, regulatory agencies may not review the application in a
timely manner and may not approve the product. Even after initial approval has been obtained, further studies, including post-marketing
studies, may be required to provide additional data on efficacy and safety necessary to confirm the approved indication or to gain
approval for the use of the new drug as a treatment for clinical indications other than those for which the new drug was initially
tested. Also, regulatory agencies require post-marketing surveillance programs to monitor a new drug’s side effects and safety.
Results of post-marketing programs may limit or expand the further marketing of new drugs. A serious safety or effectiveness problem
involving an approved new drug may result in a regulatory agency requiring withdrawal of the new drug from the market and possible
civil action. It is possible that we could encounter such difficulties or excessive costs in our efforts to secure necessary approvals,
which could delay or prevent us from manufacturing or marketing our products.



24







In addition to the regulatory
product approval framework, biotechnology companies, including Aptose, are subject to regulation under local, provincial, state
and federal law, including requirements regarding occupational safety, laboratory practices, environmental protection and hazardous
substance control, and may be subject to other present and future local, provincial, state, federal and foreign regulation, including
possible future regulation of the biotechnology industry.



Regulation in Canada



In Canada, the manufacture
and sale of new drugs are controlled by Health Canada. New drugs must pass through a number of testing stages, including pre-clinical
testing and human clinical trials. Pre-clinical testing involves testing the new drug’s chemistry, pharmacology and toxicology
in vitro and in vivo. Successful results (that is, potentially valuable pharmacological activity combined with an
acceptable low level of toxicity) enable the developer of the new drug to file a clinical trial application to begin clinical trials
involving humans.



To study a drug in Canadian
patients, a clinical trial application submission must be filed with Health Canada. The clinical trial application submission must
contain specified information, including the results of the pre-clinical tests completed at the time of the submission and any
available information regarding use of the drug in humans. In addition, since the method of manufacture may affect the efficacy
and safety of a new drug, information on manufacturing methods and standards and the stability of the drug substance and dosage
form must be presented. Production methods and quality control procedures must be in place to ensure an acceptably pure product,
essentially free of contamination, and to ensure uniformity with respect to all quality aspects.



In addition, all federally
regulated trials must be approved and monitored by an independent committee of doctors, scientists, advocates and others to ensure
safety and ethical standards. These committees are called Institutional Review Boards (“IRBs”) or Ethics Review
Boards (“ERBs”). The review boards study and approve all study-related documents before a clinical trial begins
and also carefully monitor data to detect benefit or harm, and validity of results.



Provided Health Canada
does not reject a clinical trial application submission and IRB or ERB approval has been obtained, clinical trials can begin. Clinical
trials for product candidates in Canada, as in the U.S. generally are carried out in three phases. Phase I involves studies to
evaluate toxicity and ideal dose levels in healthy humans. The new drug is administered to human patients who have met the clinical
trial entry criteria to determine pharmacokinetics, human tolerance and prevalence of any adverse side effects. Phases II and III
involve therapeutic studies. In Phase II, efficacy, dosage, side effects and safety are established in a small number of patients
who have the disease or disorder that the new drug is intended to treat. In Phase III, there are controlled clinical trials in
which the new drug is administered to a large number of patients who are likely to receive benefit from the new drug. In Phase
III, the effectiveness of the new drug in patients is compared to that of standard accepted methods of treatment in order to provide
sufficient data for the statistical proof of safety and efficacy for the new drug.



If clinical studies establish
that a new drug has value, the manufacturer submits a new drug submission application to Health Canada for marketing approval.
The new drug submission contains all information known about the new drug, including the results of pre-clinical testing and clinical
trials. Information about a substance contained in new drug submission includes its proper name, its chemical name, and details
on its method of manufacturing and purification, and its biological, pharmacological and toxicological properties. The new drug
submission also provides information about the dosage form of the new drug, including a quantitative listing of all ingredients
used in its formulation, its method of manufacture, manufacturing facility information, packaging and labelling, the results of
stability tests, and its diagnostic or therapeutic claims and side effects, as well as details of the clinical trials to support
the safety and efficacy of the new drug. Furthermore, for biological products, an on-site evaluation is completed to assess the
production process and manufacturing facility. It is required prior to the issuance of a notice of compliance. All aspects of the
new drug submission are critically reviewed by Health Canada. If a new drug submission is found satisfactory, a notice of compliance
is issued permitting the new drug to be sold for the approved use. In Canada, an establishment license must be obtained prior to
marketing the product.



Health Canada has a policy
of priority evaluation of new drug submissions for all drugs intended for serious or life-threatening diseases for which no drug
product has received regulatory approval in Canada and for which there is reasonable scientific evidence to indicate that the proposed
new drug is safe and may provide effective treatment.



25







The monitoring of a new
drug does not cease once it is on the market. For example, a manufacturer of a new drug must report any new information received
concerning serious side effects, as well as the failure of the new drug to produce desired effects. If Health Canada determines
it to be in the interest of public health, a notice of compliance for a new drug may be suspended and the new drug may be removed
from the market.



A post surveillance program
involves clinical trials conducted after a drug is marketed (referred to as Phase IV studies in the United States) and is an important
source of information on as yet undetected adverse outcomes, especially in populations that may not have been involved in the premarketing
trials (e.g., children, the elderly, pregnant women) and the drug’s long-term morbidity and mortality profile. Regulatory
authorities may require companies to conduct Phase IV studies as a condition of market approval. Companies often conduct post-marketing
studies in the absence of a regulatory mandate.



An exception to the foregoing
requirements relating to the manufacture and sale of a new drug is the limited authorization that may be available in respect of
the sale of new drugs for emergency treatment. Under the special access program, Health Canada may authorize the sale of a quantity
of a new drug for human use to a specific practitioner for the emergency treatment of a patient under the practitioner’s
care. Prior to authorization, the practitioner must supply Health Canada with information concerning the medical emergency for
which the new drug is required, such data as is in the possession of the practitioner with respect to the use, safety and efficacy
of the new drug, the names of the institutions at which the new drug is to be used and such other information as may be requested
by Health Canada. In addition, the practitioner must agree to report to both the drug manufacturer and Health Canada the results
of the new drug’s use in the medical emergency, including information concerning adverse reactions, and must account to Health
Canada for all quantities of the new drug made available.



The Canadian regulatory
approval requirements for new drugs outlined above are similar to those of other major pharmaceutical markets. While the testing
carried out in Canada is often acceptable for the purposes of regulatory submissions in other countries, individual regulatory
authorities may request supplementary testing during their assessment of any submission. Therefore, the clinical testing conducted
under Health Canada authorization or the approval of regulatory authorities of other countries may not be accepted by regulatory
authorities outside Canada or other countries.



Regulation in the United States



In the United States, the
FDA controls the manufacture and sale of new drugs. New drugs require FDA approval of a New Drug Application prior to commercial
sale. In the case of certain biological products, a Biological License Application must be obtained prior to marketing and batch
releasing. As in Canada, to obtain marketing approval, data from adequate and well-controlled human clinical trials, demonstrating
to the FDA’s satisfaction a new drug’s safety and effectiveness for its intended use, are required. Data are generated
in studies conducted pursuant to an IND submission, similar to that required for a clinical trial application in Canada. As in
Canada, clinical studies are characterized as Phase I, Phase II and Phase III trials or a combination thereof. In a marketing application,
the manufacturer must also demonstrate the identity, potency, quality and purity of the active ingredients of the new drug involved,
and the stability of those ingredients. Further, the manufacturing facilities, equipment, processes and quality controls for the
new drug must comply with the FDA’s current Good Manufacturing Practice regulations for drugs or biological products both
in a pre-licensing inspection before product licensing and in subsequent periodic inspections after licensing. An establishment
license grants the sponsor permission to fabricate, package, label, distribute, import, wholesale or test of the newly approved
drug.



The above describes briefly
what is necessary for a new drug to be approved for marketing in North America. The European Medicines Agency and Japanese Pharmaceuticals
and Medical Devices Agency are also important regulatory authorities in drug development. Together with the FDA, they are the three
International Conference on Harmonization parties which oversee the three largest markets for drug sales.



26







C.           Organizational
structure.



Old Lorus was incorporated
under the Business Corporations Act(Ontario) on September 5, 1986 under the name RML Medical Laboratories Inc. On October
28, 1991, RML Medical Laboratories Inc. amalgamated with Mint Gold Resources Ltd., resulting in Old Lorus becoming a reporting
issuer (as defined under applicable securities law) in Ontario, on such date. On August 25, 1992 Old Lorus changed its name to
IMUTEC Corporation. On November 27, 1996, Old Lorus changed its name to Imutec Pharma Inc., and on November 19, 1998, Old Lorus
changed its name to Lorus Therapeutics Inc. On October 1, 2005, Old Lorus continued under the Canada Business Corporations Act.



On the Arrangement Date,
Old Lorus completed a plan of arrangement and corporate reorganization with, among others, New Lorus, 6707157 Canada Inc. and Pinnacle
International Lands, Inc. As a result of the plan of arrangement and reorganization, each Common Share of Old Lorus was exchanged
for one Common Share of New Lorus. New Lorus continued the business of Old Lorus after the Arrangement Date with the same officers
and employees and continued to be governed by the same board of directors as Old Lorus prior to the Arrangement Date.



On August 28, 2014 New
Lorus changed its name from Lorus Therapeutics Inc. to Aptose Biosciences Inc. and on October 1, 2014 we consolidated our outstanding
Common Shares on the basis of one post-consolidation Common Share for each twelve pre-consolidation Common Shares.



The address of the Company’s
head and registered office is 2 Meridian Road, Toronto, Ontario, Canada, M9W 4Z7 and our phone number is (416) 798-1200. Our corporate
website is www.aptose.com. The contents of the website and items accessible through the website are specifically not incorporated
in this Transition Report by reference.



Aptose has two subsidiaries:
NuChem, a company incorporated under the laws of Ontario, Canada, and Aptose USA, a company incorporated under the laws of Delaware,
USA. Aptose owns 80% of the issued and outstanding voting share capital of NuChem and 100% of the issued and outstanding voting
share capital of Aptose USA. NuChem has limited activity and the non-controlling interest is not material to the consolidated financial
statements of the Company. Aptose USA was incorporated in April 2014 and did not have any activity during the seven months ended
December 31, 2014.



Our Common Shares are listed on the TSX under
the symbol “APS” and on NASDAQ under the symbol “APTO.”



D.           Property,
plant and equipment.



Our head office, which
occupies 20,500 square feet, is located at 2 Meridian Road, Toronto, Ontario. The leased premises include approximately 8,000 square
feet of laboratory and research space. Our current lease expires on March 31, 2015 and we have entered into a new lease for office
facilities in Toronto as described below..



The
lease of the current Toronto location contains certain restoration commitments which the Company will need to comply with upon
the end of the March 31, 2015 lease. The Company has recorded a provision of $300 thousand as
its current estimate of these costs.



We entered into a lease agreement for office
space, located at 12770 High Bluffs Drive, San Diego, California which occupies approximately 2,204 square feet. This leased premise
is used for administrative purposes only. This lease expires in January 2020.



In January 2015, the Company entered into a
two year lease for laboratory facility space in San Diego and in February 2015 the Company entered into a five year lease facility
in Toronto for office space and a one year agreement for laboratory space. The combined annual cost for these new locations is
expected to be $300 thousand per year.



Item 4A.           Unresolved
Staff Comments



Not applicable.



27







Item 5.          Operating
and Financial Review and Prospects



A.           Operating
results.



Please see our Management’s
Discussion and Analysis for the seven months ended December 31, 2014 in Exhibit 15.1, which is incorporated herein by reference.



B.           Liquidity
and capital resources.



Please see our Management’s
Discussion and Analysis for the seven months ended December 31, 2014 in Exhibit 15.1, which is incorporated herein by reference.



C.           Research
and development, patents and licenses, etc.



Certain information concerning
research and development and intellectual property is set forth in Item 4, “Information on the Company”.



D.           Trend
information.



We have a history of operating
losses and have not been profitable since our inception in 1986. We expect to continue to incur losses for at least the next several
years as we and our collaborators and licensees pursue clinical trials and research and development efforts. See “Item 3.
Key Information—D. Risk Factors” above.



E.           Off-balance
sheet arrangements.



As at December 31, 2014, we had not entered
into any off-balance sheet arrangements.



F.           Tabular
disclosure of contractual obligations.



As December 31, 2014



|(In thousands)              |  | Payments due by period |    
|--------------------------- |  | ---------------------- | ---
|Contractual Obligations     |  | Total                  |    
|Operating lease obligations |  | $                      | 622



The Company’s current
facility lease expires in March 2015.



In January 2015, the Company
entered into a two year lease for laboratory facility space in San Diego and in February 2015 the Company entered into a five year
lease facility in Toronto for office space and a one year agreement for laboratory space. The combined annual cost for these new
locations is expected to be $300 thousand per year.



The lease of the current
Toronto location contains certain restoration commitments with which the Company will need to comply before the end of the lease
on March 31, 201. The Company has recorded a provision of $300 thousand as its current estimate of these costs.



We hold a non-exclusive
license from Genentech Inc. to certain patent rights to develop and sub-license a certain polypeptide. We do not expect to make
any milestone or royalty payments under this agreement in the fiscal year ending December 31, 2015, and cannot reasonably predict
when such milestones and royalties will become payable, if at all.



On July 10, 2007, we completed a plan of arrangement and corporate
reorganization with Old Lorus. As part of the arrangement, we agreed to indemnify Old Lorus and its directors, officers and employees
from and against all damages, losses, expenses (including fines and penalties), other third party costs and legal expenses, to
which any of them may be subject arising out of the arrangement. We recorded a liability of $50,000, which we believe to be a reasonable
estimate of the fair value of the obligation for the indemnifications provided as at December 31, 2014. There have been no claims
on this indemnification to date.



28







G.           Safe
Harbor



Please see “Forward Looking Statements”
beginning on page 1 above.



Item 6.          Directors,
Senior Management and Employees



A.           Directors
and senior management.



The following table and
notes thereto provide the name, province or state and country of residence, positions with the Company and term of office of each
person who serves as a director or executive officer of Aptose as at the date hereof.



Each director has been
elected or appointed to serve until the next annual meeting or until a successor is elected or appointed. We have an Audit Committee,
a Corporate Governance and Nominating Committee and a Compensation Committee, the members of each such committee are shown below.



As at December 31, 2014,
our directors and executive officers, as a group, beneficially owned, directly or indirectly, or exercised control over, approximately
8,499 Common Shares or approximately 0.1% of our outstanding Common Shares.



|Name and Province/State andCountry of Residence      |  | Position                                          |  | Director or Officer Since
|---------------------------------------------------- |  | ------------------------------------------------- |  | -------------------------
|                                                     |  |                                                   |  |                          
|Directors:                                           |  |                                                   |  |                          
|Dr. Denis Burger(1)(2)
        Oregon, United States |  | Director                                          |  | September 2007           
|                                                     |  |                                                   |  |                          
|Dr. Brad Thompson(1)(2)(3)
        Alberta, Canada   |  | Director                                          |  | June 2013                
|                                                     |  |                                                   |  |                          
|Dr. Mark Vincent(3)
        Ontario, Canada          |  | Director                                          |  | September 2007           
|                                                     |  |                                                   |  |                          
|Warren Whitehead(1)
        Ontario, Canada          |  | Director                                          |  | April 2011               
|                                                     |  |                                                   |  |                          
|Dr. William Rice
        California, USA             |  | Chairman                                          |  | October 2013             
|                                                     |  |                                                   |  |                          
|Dr. Erich Platzer(2)
        Switzerland             |  | Director                                          |  | December 2014            
|                                                     |  |                                                   |  |                          
|Officers:                                            |  |                                                   |  |                          
|Dr. William Rice
        California, USA             |  | President and Chief Executive Officer             |  | October 2013             
|                                                     |  |                                                   |  |                          
|Gregory Chow
        California, USA                 |  | Senior Vice President and Chief Financial Officer |  | November 2013            
|                                                     |  |                                                   |  |                          
|Avanish Vellanki
        California, USA             |  | Senior Vice President and Chief Business Officer  |  | November 2013            



(1)         Member
of Audit Committee.



29







(2)         Member
of the Compensation Committee.

(3)         Member
of the Corporate Governance and Nominating Committee.



The principal occupation
and employment of each of the foregoing persons for the past five years is set forth below:



Dr.
Denis Burger:Dr. Burger currently is the Chairman of AMES Devices, a medical device company. Dr. Burger co-founded Trinity
Biotech plc, based in Dublin, Ireland, in June 1992 and acted as Chairman from 1992 to 1995 and now serves on the board of directors
of the company. Dr. Burger was the past Chairman, Chief Executive Officer and a director of AVI Biopharma Inc., an Oregon based
biotechnology company, from 1992 to March 2007. Dr. Burger is also a partner in Sovereign Ventures, a healthcare consulting
and funding firm based in Portland, Oregon. Dr. Burger received his MSc and Ph.D. in Microbiology and Immunology from the
University of Arizona. Dr. Burger also serves on the board of Biocurex Inc.



Dr.
Erich Platzer: Dr. Platzer is a board certified physician in internal medicine, hematology and medical oncology. Previously,
Dr. Platzer served as the business director of oncology, as well as the global strategic marketing and therapeutic area head of
oncology at Roche, Basel. He was also the medical director in oncology and global development project leader and was responsible
for various strategic corporate partnerships. Dr. Platzer is a director of Swiss Business Angel Groups, StartAngels and BioBAC,
and has served as a pharmaceutical industry expert on the board of directors of multiple biotech companies in both the U.S. and
Europe such as Probiodrug, AOT, Léman Micro Devices, Credentis, and Viroblock. Dr. Platzer co-founded and currently serves
as an investment advisor to HBM Healthcare Investments (formerly HBM BioVentures), a global leader in healthcare investing. He
has over 12 years of experience in academic medicine and research and was a key member of the team at MSKCC that purified human
G-CSF in 1983 (recombinant form: Neupogen®). He earned his M.D. from the Medical School and the Institute of Clinical Immunology
and Rheumatology of the University of Erlangen, where he also received his “Dr. med. habil.” (M.D., Ph.D.).



Dr. William Rice:
Dr. Rice joined Aptose as Chairman and Chief Executive Officer in October 2013.Prior to joining Aptose, Dr. Rice served
as the President, Chief Executive Officer and Chairman of the board of Cylene Pharmaceuticals, Inc., a private biotechnology
company (“Cylene”). Prior to Cylene, Dr. Rice was the founder, President, Chief Executive Officer and Director of Achillion
Pharmaceuticals, Inc. He also served as Senior Scientist and Head of the Drug Mechanism Laboratory at the National Cancer Institute-Frederick
Cancer Research and Development Center, and served as a faculty member in the division of Pediatric Hematology and Oncology at
Emory University School of Medicine. Dr. Rice received his Ph.D. from Emory University Department of Biochemistry. He continues
to serve as the Chairman of the board of Cylene.



Dr. Brad Thompson:
Dr. Thompson is an experienced biotechnology professional who has held the positions of Chairman of the Board and President and
Chief Executive Officer of Oncolytics Biotech Inc. since April 1999. Prior to his role with Oncolytics Dr. Thompson was the Chief
Executive Officer of Synsorb Biotech from 1994 to 1999. Dr. Thompson also currently is a board member of Immunovaccine Inc. He
received his Ph.D. from the University of Western Ontario in the Department of Microbiology and Immunology.



Dr. Mark Vincent:
Dr. Mark Vincent is a Professor of Oncology at the University of Western Ontario and a staff medical oncologist at the London
Regional Cancer Program, where he has been since 1990. Dr. Vincent is also the co-founder and Chief Executive Officer of Sarissa,
Inc. since 2000.



Mr. Warren Whitehead:Mr. Whitehead is a CPA (CMA) who has held senior financial management positions in several biotechnology and pharmaceutical
companies. Currently he is the Chief Financial Officer of Amorfix Life Sciences Ltd. Prior to this, he served as Chief Financial
Officer of ARIUS Research Inc., providing financial guidance and leadership during the acquisition of ARIUS by Roche in 2008. Prior
to ARIUS, Mr. Whitehead was Chief Financial Officer at Labopharm Inc., where he completed a series of public equity financings
and a listing on NASDAQ. He is currently the Chairman of the Board of Directors of PlantForm Corporation, a life sciences company
that develops biosimilar antibody drugs for treatment of cancer and other critical illnesses.



30







Gregory
Chow: Mr. Chow joined Aptose as Chief Financial Officer in December 2013. Previously, Mr. Chow served as Managing Director,
Director of Private Placements at Wedbush Securities, where he led the private placement capital activities within the Life Sciences
Investment Banking Group. Prior to joining Wedbush, he was a Director in the Private Placements / Equity Capital Markets Group
at RBC Capital Markets, where he led life science private capital activities. Previously, he led the Private Capital Group at Wells
Fargo Securities and was a Senior Auditor at BDO Seidman, LLP in their Century City, CA office. Mr. Chow is a Certified Public
Accountant (inactive) in the State of California.  Mr. Chow received his MBA in Finance from The Wharton School at the University
of Pennsylvania, and his BA in Business Economics with an emphasis in Accounting from the University of California, Santa Barbara.



Avanish Vellanki:
Mr. Vellanki became Aptose’s Chief Business Officer in December 2013,having mostrecently served as Senior Vice President, Investment Banking at Wedbush Securities focusing on the biotechnology sector.
Prior to Wedbush Securities, Mr. Vellanki held the position of Senior Director of Corporate Development at Proteolix, Inc. (acquired
by Onyx Pharmaceuticals), a biotechnology company focused on the development of oncology therapeutics. Previously, Mr. Vellanki
served as Vice President in the Global Healthcare Investment Banking team at Citigroup’s Global Healthcare Investment Banking,
where he focused on large cap global biopharma strategic and financial advisory. Mr. Vellanki began his career at Bear Stearns
as an equity research analyst covering the small/mid-cap biotechnology sector, and held the title of Vice President as a publishing
analyst. Mr. Vellanki holds a BA from Carleton College, an MBS in Biochemistry from the University of Minnesota and MBA from the
Carlson School of Management at the University of Minnesota.



There are no family relationships
among the persons named above and there are no arrangements or understanding with major shareholders, customers, suppliers or others
pursuant to which any person was selected as a director or member of senior management.



B.           Compensation.



Summary of Executive Compensation



The following table details
the compensation information for the seven month transition period ended December 31, 2014 of the Company, for the Chairman, President
and Chief Executive Officer, Senior Vice President and Chief Financial Officer and the Senior Vice President and Chief Business
Officer (“Named Executive Officers”).The figures are in Canadian dollars.





|Name and PrincipalPosition                            |  | 7
    monthtransitionperiod endedDecember 31 |      | Salary($) |         | Share-basedawards($) |     | Option-basedawards(2)
        ($) |  | Non-equity
    incentiveplan compensation |  | Pensionvalue($)             |        | All
        othercompensation(9)
        ($) |     | Totalcompensation($) | 
|----------------------------------------------------- |  | -------------------------------------------- | ---- | --------- | ------- | -------------------- | --- | --------------------------------- |  | ----------------------------------------- |  | --------------------------- | ------ | -------------------------------------------- | --- | -------------------- | 
|                                                      |  |                                              |      |           |         |                      |     |                                   |  | Annualincentiveplans(8) ($)               |  | Long-
termincentiveplans($) |        |                                              |     |                      | 
|Dr. William G. Rice                                   |  |                                              | 2014 |           | 321,493 | (1)                  | N/A |                                   |  | 1,868,145                                 |  | 141,217                     | (1)(3) |                                              | Nil |                      | 
|Chairman, President and Chief Executive
    Officer   |  |                                              |      |           |         |                      |     |                                   |  |                                           |  |                             |        |                                              |     |                      | 
|                                                      |  |                                              |      |           |         |                      |     |                                   |  |                                           |  |                             |        |                                              |     |                      | 
|Mr. Gregory K. Chow                                   |  |                                              | 2014 |           | 201,573 | (1)                  | N/A |                                   |  | 381,345                                   |  | 81,525                      | (1)(3) |                                              | Nil |                      | 
|Senior Vice President and Chief Financial
    Officer |  |                                              |      |           |         |                      |     |                                   |  |                                           |  |                             |        |                                              |     |                      | 
|                                                      |  |                                              |      |           |         |                      |     |                                   |  |                                           |  |                             |        |                                              |     |                      | 
|Mr. Avanish Vellanki                                  |  |                                              | 2014 |           | 201,573 | (1)                  | N/A |                                   |  | 381,345                                   |  | 81,525                      | (1)(3) |                                              | Nil |                      | 
|Senior Vice President and Chief Business
    Officer  |  |                                              |      |           |         |                      |     |                                   |  |                                           |  |                             |        |                                              |     |                      | 





| | (1) | Dr. Rice, Mr. Chow and Mr. Vellanki are paid in US dollars. Amounts are shown in Canadian dollars translated from US dollars
based on the exchange rates prevailing on the date of the transaction. The average exchange rate was $1USD = $1.09CDN.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | In determining the fair value of these option-based awards, the Black-Scholes valuation methodology was used with the following
assumptions: (i) expected life of five years; (ii) volatility 120%; (iii) risk free interest rate of 1.5%; and (iv) no dividend
yield.The Company has decided to use the Black-Scholes valuation methodology because it is equivalent to the option value
reported in the Company’s consolidated financial statements.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



31







| | (3) | Annual incentive amounts represent the expected portion of payment that will be made in fiscal
2015 allocated to the transition period. Set objectives will not be evaluated until May 31, 2015.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  | 
| |  | 

The following table details
the compensation information for the last three fiscal years of the Company, for the Chairman, President and Chief Executive Officer,
the Former President and Chief Operating Officer, the Senior Vice President and Chief Financial Officer and the Senior Vice President
and Chief Business Officer. The figures are in Canadian dollars.





|Name and Principal  Position                      |  | Year ended  May
    31 |      |  | Salary  ($) |  |         | Share- based awards
     ($) |  |  | Option-basedawards(2) ($) |     |  | Non-equity incentive  plan compensation |           | Pension  value  
     ($) |                                     |  | All
    othercompensation(9)($) |      |  | Total  compensation
     ($) | 
|------------------------------------------------- |  | ---------------------- | ---- |  | ----------- |  | ------- | ---------------------------- |  |  | ------------------------- | --- |  | --------------------------------------- | --------- | ------------------------- | ----------------------------------- |  | ------------------------------- | ---- |  | ---------------------------- | 
|                                                  |  |                        |      |  |             |  |         |                              |  |  |                           |     |  | Annualincentiveplans(8) ($)             |           |                           | Long-
term
    incentive plans  ($) |  |                                 |      |  |                              | 
|Dr. William G. Rice(3)                            |  |                        | 2014 |  |             |  | 266,806 | (10)                         |  |  | N/A                       |     |  |                                         | 1,246,742 |                           |                                     |  | 454,750                         | (10) |  | Nil                          | 
|Chairman, President and Chief Executive Officer   |  |                        | 2013 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 
|                                                  |  |                        | 2012 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 
|                                                  |  |                        |      |  |             |  |         |                              |  |  |                           |     |  |                                         |           |                           |                                     |  |                                 |      |  |                              | 
|Dr. Aiping Young (4)(5)                           |  |                        | 2014 |  |             |  | 289,971 |                              |  |  | N/A                       | (1) |  |                                         | Nil       |                           |                                     |  | Nil                             |      |  | Nil                          | 
|Former President and Chief Operating Officer      |  |                        | 2013 |  |             |  | 352,937 |                              |  |  | N/A                       |     |  |                                         | 443,100   |                           |                                     |  | 128,416                         |      |  | Nil                          | 
|                                                  |  |                        | 2012 |  |             |  | 349,334 |                              |  |  | 304,200                   | (1) |  |                                         | 49,500    |                           |                                     |  | Nil                             |      |  | Nil                          | 
|                                                  |  |                        |      |  |             |  |         |                              |  |  |                           |     |  |                                         |           |                           |                                     |  |                                 |      |  |                              | 
|Mr. Gregory K. Chow(6)                            |  |                        | 2014 |  |             |  | 125,925 | (10)                         |  |  | N/A                       |     |  |                                         | 690,625   |                           |                                     |  | 370,381                         | (10) |  | Nil                          | 
|Senior Vice President and Chief Financial Officer |  |                        | 2013 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 
|                                                  |  |                        | 2012 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 
|                                                  |  |                        |      |  |             |  |         |                              |  |  |                           |     |  |                                         |           |                           |                                     |  |                                 |      |  |                              | 
|Mr. Avanish Vellanki(7)                           |  |                        | 2014 |  |             |  | 125,925 | (10)                         |  |  | N/A                       |     |  |                                         | 690,625   |                           |                                     |  | 370,381                         | (10) |  | Nil                          | 
|Senior Vice President and Chief Business Officer  |  |                        | 2013 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 
|                                                  |  |                        | 2012 |  |             |  | -       |                              |  |  | -                         |     |  |                                         | -         |                           |                                     |  | -                               |      |  | -                            | 





| | (1) | During the year ended May 31, 2012, 65,000 (780,000 pre-consolidation) deferred share units were issued to Dr. Young. The fair value of these deferred share units is marked to market and during the fiscal year ended May 31, 2014 the fair value had increasedfrom $171,600 at May 31, 2013 to $444,600 as at April 30, 2014 resulting in an increase in value of $273,000 during the fiscal year ended May 31, 2014. The 780,000 deferred share units were redeemed by Dr. Young in consideration for 65,000 (780,000 pre-consolidation) Common Shares on April 30, 2014.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | In determining the fair value of these option-based awards, the Black-Scholes valuation methodology was used with the following assumptions: (i) expected life of five years; (ii) volatility of between 125 and 135%; (iii) risk free interest rate of between 1 and 3%; and (iv) no dividend yield.The Company has decided to use the Black-Scholes valuation methodology because it is equivalent to the option value reported in the Company’s consolidated financial statements.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Dr. Rice was named Chairman of the Board and Chief Executive Officer of the Company on October 28, 2013 and President of the Company on April 10, 2014.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------



| | (4) | Dr. Young was named Chief Operating Officer on October 28, 2013. On this date, she was replaced as Chief Executive Officer by Dr. Rice. Dr. Young left the Company on March 18, 2014.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (5) | Pursuant to the provisions of Dr. Young’s termination agreement, 43,750 (525,000 pre-consolidation) unvested options vested as of April 22, 2014, and the total 110,417 (1,325,000 pre-consolidation) vested options held by Dr. Young as of April 22, 2014 will expire on March 18, 2015.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (6) | Mr. Chow was named Chief Financial Officer on December 2, 2013 and Senior Vice President on April 10, 2014.
| | --- | -----------------------------------------------------------------------------------------------------------



| | (7) | Mr. Vellanki was named Chief Business Officer on December 2, 2013 and Senior Vice President on April 10, 2014.
| | --- | --------------------------------------------------------------------------------------------------------------



| | (8) | During the year one-time bonuses were paid to Named Executive Officers upon the completion of key financing milestones. These amounts were approved by the Board and have been included in the Annual Incentive Plan column.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



32







| | (9) | Other compensation for Dr. Rice, Mr. Chow and Mr. Vellanki relates to consulting fees paid to Named Executive Officers for services provided prior to employment. Other compensation paid to Dr. Young was pursuant to the provisions of Dr. Young’s termination agreement.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (10) | Dr. Rice, Mr. Chow and Mr. Vellanki are paid in US dollars. Amounts are shown in Canadian dollars translated from US dollars based on the exchange rates prevailing on the date of the transaction. The average exchange rate was $1USD = $1.07CDN.
| | ---- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





|Name and Principal
Position                       |  | 7 month
transition
period ended
December 31 |      |  | Salary  ($) |  |         | Cash  Bonus  ($) |  |  | Other Annual  Compensation    ($) |        | Securities
Under  Options/SARs  Granted  (#) |     |  | All Other  Compensation  ($)
|------------------------------------------------- |  | ------------------------------------------- | ---- |  | ----------- |  | ------- | ---------------- |  |  | --------------------------------- | ------ | -------------------------------------------- | --- |  | ----------------------------
|Dr. William G. Rice                               |  |                                             | 2014 |  |             |  | 321,493 | (1)              |  |  | 141,217                           | (1)(2) |                                              | Nil |  |                             
|Chairman, President and Chief Executive Officer   |  |                                             |      |  |             |  |         |                  |  |  |                                   |        |                                              |     |  |                             
|                                                  |  |                                             |      |  |             |  |         |                  |  |  |                                   |        |                                              |     |  |                             
|Mr. Gregory K. Chow                               |  |                                             | 2014 |  |             |  | 201,573 | (1)              |  |  | 81,525                            | (1)(2) |                                              | Nil |  |                             
|Senior Vice President and Chief Financial Officer |  |                                             |      |  |             |  |         |                  |  |  |                                   |        |                                              |     |  |                             
|                                                  |  |                                             |      |  |             |  |         |                  |  |  |                                   |        |                                              |     |  |                             
|Mr. Avanish Vellanki                              |  |                                             | 2014 |  |             |  | 201,573 | (1)              |  |  | 81,525                            | (1)(2) |                                              | Nil |  |                             
|Senior Vice President and Chief Business Officer  |  |                                             |      |  |             |  |         |                  |  |  |                                   |        |                                              |     |  |                             







| | (1) | Dr. Rice, Mr. Chow and Mr. Vellanki are paid in US dollars. Amounts are shown in Canadian dollars translated from US dollars
based on the exchange rates prevailing on the date of the transaction. The average exchange rate was $1USD = $1.09CDN.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Annual incentive amounts represent the expected portion of payment that will be made in fiscal 2015 allocated to the transition
period. Set objectives will not be evaluated until May 31, 2015.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





|Name and Principal
Position                           |  | Year
    Ended  May 31, |      |  | Salary   
    ($) |  |         | CashBonus(1)(6)($) |  |  | Other Annual
     Compensation    ($) |     | Securities

    Under  Options/SARs  Granted  (#) |     |  | All
    Other
Compensation(7) ($) |        
|----------------------------------------------------- |  | ----------------------- | ---- |  | ----------------- |  | ------- | ------------------ |  |  | ------------------------------------- | --- | ------------------------------------------------- | --- |  | --------------------------------- | -------
|Dr.
    William G. Rice(2)                            |  |                         | 2014 |  |                   |  | 266,806 | (8)                |  |  | 454,750                               | (8) |                                                   | Nil |  |                                   | 245,833
|Chairman, President and Chief
    Executive Officer   |  |                         | 2013 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      
|                                                      |  |                         | 2012 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      
|                                                      |  |                         |      |  |                   |  |         |                    |  |  |                                       |     |                                                   |     |  |                                   |        
|Dr.
    Aiping Young (3)(5)(6)                        |  |                         | 2014 |  |                   |  | 289,971 |                    |  |  | Nil                                   |     |                                                   | Nil |  |                                   | Nil    
|Former President and Chief
    Operating Officer      |  |                         | 2013 |  |                   |  | 352,937 |                    |  |  | 128,416                               |     |                                                   | Nil |  |                                   | 83,333 
|                                                      |  |                         | 2012 |  |                   |  | 349,334 |                    |  |  | Nil                                   |     |                                                   | Nil |  |                                   | 27,500 
|                                                      |  |                         |      |  |                   |  |         |                    |  |  |                                       |     |                                                   |     |  |                                   |        
|Mr.
    Gregory K. Chow(4)                            |  |                         | 2014 |  |                   |  | 125,925 | (8)                |  |  | 370,381                               | (8) |                                                   | Nil |  |                                   | 106,250
|Senior Vice President and
    Chief Financial Officer |  |                         | 2013 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      
|                                                      |  |                         | 2012 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      
|                                                      |  |                         |      |  |                   |  |         |                    |  |  |                                       |     |                                                   |     |  |                                   |        
|Mr. Avanish Vellanki(5)                               |  |                         | 2014 |  |                   |  | 125,925 | (8)                |  |  | 370,381                               | (8) |                                                   | Nil |  |                                   | 106,250
|Senior Vice President and
    Chief Business Officer  |  |                         | 2013 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      
|                                                      |  |                         | 2012 |  |                   |  | -       |                    |  |  | -                                     |     |                                                   | Nil |  |                                   | -      







| | (1) | Cash bonuses are assessed by the Compensation Committee and approved by the Board based on corporate objectives. Bonuses for the year ended May 31, 2014 were paid in seven months ended December 31, 2014.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Dr. Rice was named Chairman of the Board and Chief Executive Officer of the Company on October 28, 2013 and President of the Company on April 10, 2014.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------



| | (3) | Dr. Aiping Young was named Chief Operating Officer on October 28, 2013. On this date, she was replaced as Chief Executive Officer by Dr.. Rice. Dr. Young left the Company on March 18, 2014.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



33







| | (4) | Mr. Chow was named Chief Financial Officer on December 2, 2013 and Senior Vice President on April 10, 2014.   
| | --- | --------------------------------------------------------------------------------------------------------------
| |     |                                                                                                               
| | (5) | Mr. Vellanki was named Chief Business Officer on December 2, 2013 and Senior Vice President on April 10, 2014.



| | (6) | During the year one-time bonuses were paid to Named Executive Officers upon the completion of key financing milestones. These amounts were approved by the Board and have been included in the Cash Bonus column.
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (7) | Other compensation for Dr. Rice, Mr. Chow and Mr. Vellanki relates to consulting fees paid to Named Executive Officers for services provided prior to employment. Other compensation paid to Dr. Young was pursuant to the provisions of Dr. Young’s termination agreement.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (8) | Dr. Rice, Mr. Chow and Mr. Vellanki are paid in US dollars. Amounts are shown in Canadian dollars translated from US dollars based on the exchange rates prevailing on the date of the transaction. The average exchange rate was $1USD = $1.07CDN.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Directors’ Compensation



The following table details
the compensation received by each director for the transition period ended December 31, 2014:



|Name                   |  | Fees earned   ($) |        |  | Share-based awards  ($) |  |     | Option- based awards ($) |  |  | Non-equity  incentive plan compensation ($) |  | Pension value  ($) |     |  | All other  Compensation  ($) |     | Total    ($) | 
|---------------------- |  | ----------------- | ------ |  | ----------------------- |  | --- | ------------------------ |  |  | ------------------------------------------- |  | ------------------ | --- |  | ---------------------------- | --- | ------------ | 
|                       |  |                   |        |  |                         |  |     |                          |  |  |                                             |  |                    |     |  |                              |     |              | 
|Dr. Denis Burger       |  |                   | 28,288 |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 
|Dr. Bradley Thompson   |  |                   | 24,000 |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 
|Dr. Brian Underdown(3) |  |                   | 17,750 |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 
|Dr. Mark Vincent       |  |                   | 22,500 |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 
|Mr. Warren Whitehead   |  |                   | 25,000 |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 
|Dr. Jim Wright(1)      |  |                   | nil    |  |                         |  | nil |                          |  |  | 107,860                                     |  |                    | nil |  |                              | nil |              | 
|Dr. Erich Platzer(2)   |  |                   | nil    |  |                         |  | nil |                          |  |  | nil                                         |  |                    | nil |  |                              | nil |              | 



Dr. Rice did not receive any compensation
for his role as a director of the Company.



| | (1) | Dr. Wright did not stand for re-election at the Company Annual General Meeting on August 19, 2014. The option-based award expense related to Dr. Wright reflects the incremental value associated with a change in expiry date of his outstanding options.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | Dr. Platzer was appointed to the Board on December 15, 2014.
| | --- | ------------------------------------------------------------
| |     |                                                             
| | (3) | Dr. Underdown resigned from the Board on December 15, 2014. 



There were no options
issued to the directors during the transition period ended December 31, 2014. Compensation for each director consisted of an annual
fee of $15,000 and $1,500 per Board meeting attended. Members of the Audit Committee received an annual fee of $8,000 (the Chair
of the Audit Committee received $10,000). Each member of the Compensation Committee and Corporate Governance and Nominating Committee
received an annual fee of $5,000 per committee. Board members receive $500 for meetings held via conference call. Non-executive
directors are reimbursed for any out-of pocket travel expenses incurred in order to attend meetings. Executive directors are not
entitled to directors’ compensation.



34







In January 2015, the Board
approved certain changes related to the compensation of directors effective for the fiscal year 2015. As of January 1, 2015, directors
will be entitled to an annual fee of $30,000 with no per meeting fees. The lead director will be entitled to an additional annual
fee of $30,000. The chair of each committee will be entitled to an annual fee of $10,000 with each committee member receiving
an annual fee of $6,000 per committee. Upon appointment to the Board a director will be entitled to an option grant of 10,000
options and each year thereafter an additional grant of 6,000 options.



Directors are entitled
to participate in the DSU Plan. None of our directors participated in this plan in the seven months ended December 31, 2014 or
the fiscal year ended May 31, 2014.



Management Contracts



The employment agreements
of Dr. Rice, Mr. Chow and Mr. Vellanki provide that if their employment is terminated by the Company other than for cause, each
of Dr. Rice, Mr. Chow and Mr. Vellanki shall be entitled to a payment equivalent to 12 months of their respective annual base
salaries at the time of termination (Dr. Rice’s current annual base salary represents US$480,000, Mr. Chow’s
current annual base salary represents US$315,000 and Mr. Vellanki’s current annual base salary represents US$315,000),
plus an amount equal to the average bonus remuneration received from the Company during the last three years of employment completed
prior to the termination date, prorated based on the number of days the executive worked during the year of the termination. In
addition, the employment agreements of Dr. Rice, Mr. Chow and Mr. Vellanki provide that certain payments related to health
benefits will continue to be made for a period of 12 months following termination of their employment.



If the employment agreements
are terminated by the Company other than for cause, then all unexercised options then held by each are governed by the terms of
the share option plan of the Company (“Share Option Plan”).



The employment agreements
of Dr. Rice, Mr. Chow and Mr. Vellanki provide that, in the event their employment with the Company is terminated within three
months immediately preceding or 12 months immediately following the consummation of a change of control, each of Dr. Rice, Mr.
Chow and Mr. Vellanki would be eligible, subject to certain conditions, to receive a payment equivalent to 18 months of their
annual base salaries at the time of termination, plus an amount equal to 150% of the average bonus remuneration received from the
Company during the last three years of employment completed prior to the termination date, prorated based on the number of days
the executive worked during the year of the termination, as well as continuation of the payments related to health benefits for
a period of 12 months following the termination following a change of control.



The following table sets
out the amount that would have been payable to each Named Executive Officer had there been a change of control of the Company on
December 31, 2014 and the severance payment that would have been payable to each Named Executive Officer had the Company terminated
employment of the Named Executive Officer without cause on December 31, 2014:



|Name                 |  | Termination Without Cause |            |     | Change of Control | 
|-------------------- |  | ------------------------- | ---------- | --- | ----------------- | 
|Dr. William G. Rice  |  |                           | US$785,000 | (1) |                   | 
|Mr. Gregory K. Chow  |  |                           | US$471,000 | (1) |                   | 
|Mr. Avanish Vellanki |  |                           | US$504,000 | (1) |                   | 



| | (1) | This amount represents 12 months of annual base salary at the time of termination, plus an amount equal to the average bonus remuneration received from the Company during the last three years of employment completed prior to the termination date, prorated based on the number of days the executive worked during the year of the termination, as well as continuation of the payments related to health benefits for a period of 12 months following the termination.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (2) | This amount represents 18 months of annual base salary at the time of termination, plus an amount equal to 150% of the average bonus remuneration received from the Company during the last three years of employment completed prior to the termination date, prorated based on the number of days the executive worked during the year of the termination, as well as continuation of the payments related to health benefits for a period of 12 months following the termination.
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



35







Equity Compensation Plans



The following table sets forth certain details
as at the end of the transition period ended December 31, 2014 with respect to compensation plans pursuant to which equity
securities of the Company are authorized for issuance.



|                                                   |  | Number of
    Shares to be issued upon exercise of outstanding options, warrants and rights (a) |           |  | Weighted-
    average exercise price of  outstanding options, warrants and rights (b) |  | Number of
    Shares remaining available for future issuance  under the  equity  compensation plans
    (Excluding Shares reflected in Column (a)) (c) |   |  | Total
    options, warrants and rights outstanding and available for grant (a) + (c) |       
|-------------------------------------------------- |  | ----------------------------------------------------------------------------------------------- | --------- |  | ------------------------------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------ | - |  | ------------------------------------------------------------------------------------ | ------
|Plan Category                                      |  | Number                                                                                          |           |  | % of
    Shares outstanding                                                           |  |                                                                                                                                                        |   |  |                                                                                      | Number
|Equity compensation plans approved by Shareholders |  |                                                                                                 | 1,374,013 |  |                                                                                       |  | 11.7                                                                                                                                                   | % |  | $                                                                                    |       



Share Option Plan



The Share Option Plan was
established to advance the interests of Aptose by:



| | · | providing Eligible Persons (as defined below) with additional incentives;
| | - | -------------------------------------------------------------------------



| | · | encouraging stock ownership by Eligible Persons;
| | - | ------------------------------------------------



| | · | increasing the interest of Eligible Persons in the success of Aptose;
| | - | ---------------------------------------------------------------------



| | · | encouraging Eligible Persons to remain loyal to Aptose; and
| | - | -----------------------------------------------------------



| | · | attracting new Eligible Persons to Aptose.
| | - | ------------------------------------------



The Compensation Committee,
as authorized by the Board, administers the Share Option Plan. The maximum total number of Common Shares available for issuance
from treasury under the Share Option Plan, together with the DSU Plan, the ACP and any other security based compensation arrangement
is 15% of the Company’s issued and outstanding Common Shares at any given time. Any exercise of options pursuant to the Share
Option Plan will make new option grants available under the Share Option Plan, provided that the maximum number of Common Shares
reserved for issuance collectively under the Share Option Plan, the DSU Plan and the ACP may not exceed 15% of the Company’s
issued and outstanding Common Shares at any given time.



Under the Share Option
Plan, options may be granted to any executive officer, employee, subsidiary of an executive officer or employee, or consultant
or consultant entity (“Eligible Persons”). The exercise price of options granted under the Share Option Plan
is established by the Board and will be equal to the closing market price of the Common Shares on the TSX on the last trading day
preceding the date of grant. If there is no trading on that date, the exercise price will be the average of the bid and ask on
the TSX on the last trading date preceding the date of grant. If not otherwise determined by the Board, an option granted under
the Share Option Plan will vest as to 50% on the first anniversary of the date of grant of the option and an additional 25% on
the second and third anniversaries after the date of grant. The Board fixes the term of each option when granted, but such term
may not be greater than 10 years from the date of grant. If the date on which an option expires pursuant to an option agreement
occurs during, or within 10 days after the last day of, a black out period or other restriction period imposed on the trading of
Common Shares by the Company, the expiry date for the option will be the last day of the 10-day period. Options are personal to
the participant and a participant may not transfer an option except in accordance with the Share Option Plan.



The Board may, its sole
discretion, amend, suspend or terminate the Share Option Plan or any portion of it at any time in accordance with applicable legislation,
without obtaining the approval of Shareholders. Any amendment to any provision of the Share Option Plan is subject to any required
regulatory or Shareholder approval. The Company is, however, required to obtain the approval of the Shareholders for any amendment
related to (i) the maximum number of Common Shares reserved for issuance under the Share Option Plan, and under any other security
based compensation arrangements of the Company; (ii) a reduction in the exercise price for options held by insiders of the Company;
and (iii) an extension to the term of options held by insiders of the Company.



36







If an option holder is
terminated without cause, resigns or retires, each option that has vested will cease to be exercisable three months after
the option holder’s termination date. Any portion of an option that has not vested on or prior to the termination date will
expire immediately. If an option holder is terminated for cause, each option that has vested will cease to be exercisable immediately
upon the Company’s notice of termination. Any portion of an option that has not vested on or prior to the termination date
will expire immediately.



Alternate Compensation Plan



The Company has an alternate
compensation plan (“ACP”) which enables Aptose to meet its obligations to pay directors’ fees, salary
and performance bonuses to certain employees in the form of Common Shares. The ACP permits the Company to, in circumstances considered
appropriate by the Board, encourage the ownership of equity of the Company by its directors and senior employees (“ACP
Participants”), enhance the Company’s ability to retain key personnel and reward significant performance achievements
while preserving the cash resources of the Company.



Under the ACP, ACP Participants
have the option of receiving director’s fees, salary, bonuses or other remuneration, as applicable (“Remuneration”)
by the allotment and issuance from treasury of such number of Common Shares as will be equivalent to the cash value of the Remuneration
determined by dividing the Remuneration by the weighted average closing Common Share price for the five (5) trading days prior
to payment date (the “5-day VWAP”). The issue price of Common Shares issued under the ACP is the 5-day VWAP.
Upon ceasing to be an ACP Participant, such ACP Participant will no longer be eligible to receive Common Shares under the ACP and
any amounts owing to such ACP Participant shall be paid without reference to the ACP Participant.



The maximum number of Common
Shares reserved for issuance under the ACP, when combined with the Share Option Plan and the DSU Plan, shall not exceed 15% of
the Company’s issued and outstanding Common Shares at any given time.



There have been nil Common
Shares issued under the ACP during the seven months ended December 31, 2014. Since December 31, 2014, there have been nil Common
Shares issued under the ACP.



The Board may, at any time
and from time to time, amend, suspend or terminate the ACP without Shareholder approval, provided that no such amendment, suspension
or termination may be made without obtaining any required approval of any regulatory authority or stock exchange. Notwithstanding
the foregoing, the Board may not, without the approval of the shareholders, make amendments to the ACP to increase the maximum
number of Common Shares issuable under the ACP, or to amend the provisions regarding Shareholder approval.



Deferred Share Units Plan



The Company adopted the
DSU Plan which provides that participating directors and senior officers (“DSU Participants”) may elect to receive
either a portion or all of the remuneration to be received from the Company in deferred share units. Such remuneration includes
all amounts payable in cash or Common Shares (subject to election otherwise under the DSU Plan) to a DSU Participant by the Company
or a subsidiary of the Company in respect of the services provided to the Company or subsidiary by the DSU Participant in any calendar
year, including (a): in the case of a director, without limitation, (i) annual Board or committee of the Board or advisory retainer
fees, (ii) fees for attending meetings of the Board or a committee of the Board and (iii) fees for serving as chairman or chairwoman
of any committee of the Board, but, for greater certainty, excluding amounts payable to a DSU Participant as a reimbursement for
expenses incurred in attending meetings; and (b): in the case of a senior officer, without limitation, those services for which
a salary or cash bonus would normally be paid, provided that the relevant performance criteria which serve as a basis for the granting
of such bonuses have been met.



37







Under the DSU Plan, the
deferred share units that DSU Participants elect to receive for remuneration earned are credited to each DSU Participant’s
account in an amount of units equal to the gross amount of remuneration to be deferred divided by the fair market value of the
Common Shares, being the closing price of the Common Shares on the TSX on the day immediately preceding the recommendation by the
Compensation Committee or such other amount as determined by the Board and permitted by the applicable regulatory authorities.
Rights respecting deferred share units are not transferable or assignable other than by will or by the laws of descent and distribution.



A DSU Participant who has
retired, resigned or has been terminated without cause from all positions with the Company and any subsidiary of the Company may
redeem the deferred share units credited to the DSU Participant’s account. Subject to the approval of the Compensation Committee,
the DSU Participant may indicate what portion of the payment is to be paid in cash and what portion is to be paid in Common Shares.
A DSU Participant who has been terminated with cause may not redeem the deferred share units held by that DSU Participant and those
deferred share units so held will be deemed cancelled as of the date of termination of the DSU Participant.



The maximum number of Common
Shares reserved for issuance under the DSU Plan, when combined with the Share Option Plan and the ACP, shall not exceed 15% of
the Company’s issued and outstanding Common Shares at any given time.



During the period from
June 1, 2014 to December 31, 2014, nil deferred share units were outstanding under the DSU Plan. Since December 31, 2014,
there have been nil deferred share units issued under the DSU Plan.



The Board may amend the
DSU Plan as it deems necessary or appropriate without Shareholder approval, subject to applicable corporate, securities and tax
law requirements, but no amendment will, without the consent of the DSU Participant or unless required by law, adversely affect
the rights of a DSU Participant with respect to deferred share units that have been credited to the account of the DSU Participant
at the time of such amendment to the DSU Plan. Notwithstanding the foregoing, the Board must obtain Shareholder approval to increase
to the maximum number of securities reserved for issuance under the DSU Plan or any other security based compensation arrangement,
or to amend the provisions regarding Shareholder approval.



Employee Share Purchase Plan



We have an Employee Share
Purchase Plan (“ESPP”), the purpose of which is to assist the Company in retaining the services of its employees,
securing and retaining the services of new employees and providing incentives for such persons to exert maximum efforts for the
success of the Company. The ESPP provides a means by which employees of the Company and its affiliates may purchase Common Shares
on the stock market at a 15% discount through accumulated payroll deductions. Eligible participants in the ESPP include all employees,
including executive officers, who work at least 20 hours per week and are customarily employed by the Company or an affiliate
of the Company for at least six months per calendar year. Generally, each offering is of three months’ duration with purchases
occurring every quarter. Participants may authorize payroll deductions of up to 15% of their base compensation for the purchase
of Common Shares under the ESPP.



During the transition period
ended December 31, 2014, under the ESPP, Named Executive Officers, as a group, and employees did not purchase any Common Shares
pursuant to the ESPP.Since December 31, 2014, there have been no Common Shares purchased pursuant to the ESPP.



Option Grants During The Seven Months Ended
December 31, 2014



The following tables set
forth the options granted to and exercised by each of the Named Executive Officers during the seven months ended December 31,
2014:



38







Option/SAR Grants During the Most Recently
Completed Financial Year



|Name and Principal Position |  | Securities Under  Options/SARs  Granted  (#) |         |  | % of Total  Options/SARs  Granted to Employees in Financial  Year  (%) |  |    | Exercise or  Base Price    ($/Security) |  |   | Market Value of  Securities Underlying Options/SARs  on the Date of Grant  ($/Security) |  |  | Expiration  Date
|--------------------------- |  | -------------------------------------------- | ------- |  | ---------------------------------------------------------------------- |  | -- | --------------------------------------- |  | - | --------------------------------------------------------------------------------------- |  |  | ----------------
|                            |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|Dr. William G. Rice         |  |                                              | 396,129 |  |                                                                        |  | 66 | %                                       |  | $ | 5.70                                                                                    |  |  | $               
|Chairman, President and     |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|Chief Executive Officer     |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|                            |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|Mr. Gregory K. Chow         |  |                                              | 22,083  |  |                                                                        |  | 4  | %                                       |  | $ | 5.70                                                                                    |  |  | $               
|Senior Vice President and   |  |                                              | 64,167  |  |                                                                        |  | 11 | %                                       |  | $ | 5.22                                                                                    |  |  | $               
|Chief Financial Officer     |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|                            |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 
|Mr. Avanish Vellanki        |  |                                              | 22,083  |  |                                                                        |  | 4  | %                                       |  | $ | 5.70                                                                                    |  |  | $               
|Senior Vice President and   |  |                                              | 64,167  |  |                                                                        |  | 11 | %                                       |  | $ | 5.22                                                                                    |  |  | $               
|Chief Business Officer      |  |                                              |         |  |                                                                        |  |    |                                         |  |   |                                                                                         |  |  |                 



Incentive Compensation Plans



Outstanding Share-Based Awards
and Option-Based Awards



The following table shows
all awards outstanding to each Named Executive Officer as at December 31, 2014:



|                                                                           |  | Option-based Awards                                            |  | Share-based Awards           
|-------------------------------------------------------------------------- |  | -------------------------------------------------------------- |  | -----------------------------
|Name and Principal
    Position                                            |  | Number 
    of  securities  underlying unexercised options (#) |  | Option
    exercise price ($)
|Dr. William G. Rice  Chairman, President and Chief Executive
    Officer   |  | 35,417 65,136 5,281 140,000 396,129                            |  | 3.48 7.32 6.96 6.00 5.70     
|                                                                           |  |                                                                |  |                              
|Mr. Gregory K. Chow  Senior Vice President and Chief Financial
    Officer |  | 35,417 35,417 35,417 22,083 64,167                             |  | 9.36 7.32 6.00 5.70 5.22     
|                                                                           |  |                                                                |  |                              
|Mr. Avanish Vellanki  Senior Vice President and Chief Business
    Officer |  | 35,417 35,417 35,417 22,083 64,167                             |  | 9.36 7.32 6.00 5.70 5.22     



| | (1) | These amounts are calculated based on the difference between the market value of the securities underlying the options on December 31, 2014 at the end of the fiscal year ($6.87), and the exercise price of the options.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



39







Aggregated Option/SAR Exercises During
the Seven Months Ended December 31, 2014

and Financial Year-End Option/SAR Values



|Name                                                                   |  | Securities  Acquired on  Exercise  (#) |  | Aggregate  Value  Realized  ($) |  | Unexercised  Options/SARs at  December 31, 2014  (#)  Exercisable/Unexercisable |  | Value of Unexercised  in-the-Money  Options/SARs at  December 31, 2014  ($)  Exercisable/Unexercisable
|---------------------------------------------------------------------- |  | -------------------------------------- |  | ------------------------------- |  | ------------------------------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------------
|                                                                       |  |                                        |  |                                 |  |                                                                                 |  |                                                                                                       
|Dr. William G. Rice  Chairman, President and Chief Executive Officer   |  | nil                                    |  | nil                             |  | 67,985/573,978                                                                  |  | 120,064/585,271                                                                                       
|                                                                       |  |                                        |  |                                 |  |                                                                                 |  |                                                                                                       
|Mr. Gregory K. Chow  Senior Vice President and Chief Financial Officer |  | nil                                    |  | nil                             |  | 69,329/123,172                                                                  |  | 6,847/155,678                                                                                         
|                                                                       |  |                                        |  |                                 |  |                                                                                 |  |                                                                                                       
|Mr. Avanish Vellanki  Senior Vice President and Chief Business Officer |  | nil                                    |  | nil                             |  | 69,329/123,172                                                                  |  | 6,847/155,678                                                                                         



| | C. | Board practices.
| | -- | ----------------



Aptose is authorized to
have a board of at least one director and no more than ten. Aptose currently has six directors. Directors are elected for a term
of approximately one year, from annual meeting to annual meeting, or until an earlier resignation, death or removal. For the dates
our current directors assumed their directorships, see Item 6.A. – “Directors and Senior Management” above.



Each officer serves at
the discretion of the Board or until an earlier resignation or death. There are no family relationships among any of our directors
or officers.



Our non-management directors
have no service contracts with us or our subsidiaries that provide for benefits upon termination of employment. See “—Management
Contracts” above for a summary of key employment agreements.



Committees of the Board of Directors



The Company has an Audit
Committee, a Nominating and Corporate Governance Committee and a Compensation Committee.



The members of these committees
during the seven months ended December 31, 2014 were as follows:



|Audit Committee                                |  | Denis Burger, Brian Underdown, Warren Whitehead
|---------------------------------------------- |  | -----------------------------------------------
|Nominating and Corporate Governance Committee: |  | Bradley Thompson, Mark Vincent                 
|Compensation Committee:                        |  | Denis Burger, Brian Underdown                  



On December 15, 2014 Brian
Underdown resigned from the Board and also from the Audit Committee and Compensation Committee. On January 16, 2015 Bradley Thompson
was appointed to the Audit Committee and Erich Platzer was appointed to the Compensation Committee.



Compensation Committee



Composition of the Compensation Committee



The Board, upon the advice
of the Compensation Committee, determines executive compensation. The Compensation Committee is currently comprised of independent
Board members Dr. Burger and Dr. Underdown. Dr. Burger is chair of the Compensation Committee. The Compensation Committee
met 3 times during the period from June 1, 2014 until December 31, 2014.



Members of the Compensation
Committee each have direct experience relevant to compensation matters resulting from their respective current and past activities.
The members of the Compensation Committee have experience dealing with compensation matters in comparable organizations, including
public companies, as well as companies with a strong emphasis on governance in their current and former roles as principal executives.



40







Compensation Objectives and Philosophy



The Compensation Committee’s
mandate is to review and advise the Board on the recruitment, appointment, performance, compensation, benefits and termination
of executive officers. The Compensation Committee also administers and reviews procedures and policies with respect to the Share
Option Plan, the DSU Plan, the ACP, employee benefit programs, pay equity and employment equity and reviews executive compensation
disclosure where it is publicly disclosed.



Aptose’s executive compensation program is designed to:



| | · | attract and retain qualified, motivated and achievement-oriented individuals by offering compensation that is competitive in the industry and marketplace;
| | - | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | align executive interests with the interests of shareholders; and
| | - | -----------------------------------------------------------------



| | · | ensure that individuals continue to be compensated in accordance with their personal performance and responsibilities and their contribution to the overall objectives of the Company.
| | - | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



These objectives are achieved
by offering executives and employees a compensation package that is competitive and rewards the achievement of both short-term
and long-term objectives of the Company. As such, our compensation package consists of three key elements:



| | · | base salary and initial share options;
| | - | --------------------------------------



| | · | short-term compensation incentives to reward corporate and personal performance through potential annual cash bonuses; and
| | - | --------------------------------------------------------------------------------------------------------------------------



| | · | long-term compensation incentives related to long-term increase in share value through participation in the Share Option Plan.
| | - | ------------------------------------------------------------------------------------------------------------------------------



The Compensation Committee
reviews each of these items on a stand-alone basis and also reviews compensation as a total package. Adjustments to compensation
are made as appropriate following a review of the compensation package as a whole.



Base Salary — Initial Share
Options



In establishing base salaries,
the objective of the Compensation Committee is to establish levels that will enable Aptose to attract and retain executive officers
that can effectively contribute to the long-term success of the Company. Base salary for each executive officer is determined by
the individual’s skills, abilities, experience, past performance and anticipated future contribution to the success of Aptose.
The members of the Compensation Committee use their knowledge of the industry and of industry trends to assist with the determination
of an appropriate compensation package for each executive officer. In certain cases, the Compensation Committee may recommend inclusion
of automobile allowances, fitness allowances and the payment of certain professional dues as a component of an overall remuneration
package for executives.



In certain cases, executive
officers may be granted share options on the commencement of employment with Aptose in accordance with the responsibility delegated
to each executive officer for achieving corporate objectives and enhancing shareholder value in accordance with those objectives.



41







Short-Term Compensation
Incentives



The role of short-term
compensation incentives at Aptose is to motivate our executive officers to achieve specified performance objectives for 2014 and
to reward them for their achievement in the event that those objectives are met. Each year, the Compensation Committee approves
the annual corporate objectives encompassing scientific, clinical, regulatory, business and corporate development and financial
criteria. The annual cash bonus for the executive officers is based, at least in part, on the level of achievement of these annual
objectives, assuming these objectives are still relevant at the time of evaluation.



All corporate and executive
officer objectives are reviewed by the Compensation Committee and approved by the Board. The Compensation Committee recommends
to the Board the awarding of bonuses, payable in cash, stock or share options, to reward extraordinary individual performance.



For each executive officer,
during the seven months ended December 31, 2014, the annual cash bonuses ranged from 40% to 45% of base salary when all corporate
and individual executive officer objectives were achieved.



Cash bonuses are determined
as soon as practicable after the end of the fiscal year and, for the Named Executive Officers (as defined hereinafter), are included
in the Summary Compensation Table in the year in respect of which they are earned.



Long-Term Incentive Plan



The role of long-term compensation
incentives at Aptose is to reward an executive’s contribution to the attainment of Aptose’s long-term objectives, align
an executive’s performance with the long-term performance of Aptose and to provide an additional incentive for an executive
to enhance shareholder value. Long-term incentive compensation for directors, officers, employees and consultants is reviewed annually
and is accomplished through the grant of share options under our Share Option Plan.



The number of options granted
for certain executives of Aptose for the seven months ended December 31, 2014 was based on achievement of both corporate and
executive officer objectives. The Compensation Committee approves the allocation of options and options are priced using the closing
market price of the Common Shares on the TSX on the last trading day prior to the date of grant. Options to purchase Common Shares
expire ten years from the date of grant and vest over a term determined by the Compensation Committee. The Compensation Committee
takes into account previous grants of options when considering new grant of options.



The granting of options
to Named Executive Officers is included in the Summary Compensation Table in the year in which they are earned.



Performance Metrics



The performance of the
Named Executive Officers for the seven months ended December 31, 2014 was measured with respect to the following objectives:



| | 1) | Initiate APTO-253 Phase Ib Clinical trial and manage patient enrollment ;
| | -- | -------------------------------------------------------------------------



| | 2) | Company rebranding and NASDAQ listing;
| | -- | --------------------------------------



| | 3) | Further strengthening of the management team;
| | -- | ---------------------------------------------



| | 4) | Other corporate objectives.
| | -- | ---------------------------



Each of the above objectives is weighted at
30%, 20%, 20% and 30% respectively in relation to assessment of satisfaction of overall corporate objective s and determination
of any general corporate bonuses. As this is a transition period, the measurement period of these corporate objectives carries
into fiscal 2015 and were not measured as of December 31, 2014. Incentive compensation related to the attainment of these objectives
will be paid in fiscal 2015.



42







Hedge or Offset Instruments



Named Executive Officers
or directors are not permitted to purchase financial instruments that are designed to hedge or offset a decrease in market value
of equity securities granted as compensation or held, directly or indirectly, by Named Executive Officers or directors, including,
for greater certainty, prepaid variable forward contracts, equity swaps, collars, or units of exchange funds.



Risk Assessment of Compensation



The implications of the
risks associated with the Company’s compensation practices were not considered by the Board or a committee of the Board.



Audit Committee



The charter of our Audit
Committee is attached as Exhibit 11.2. The current members of the Audit Committee are Bradley Thompson, Denis Burger and Warren
Whitehead. Bradley Thompson was appointed to the Audit Committee on January 16, 2015 following Brian Underdown’s resignation
from the Audit Committee on December 15, 2014. Mr. Warren Whitehead is the Chairman of the Audit Committee and has been considered
to be the Financial Expert. Pursuant to Canadian securities laws, our board of directors has determined that Messrs. Thompson,
Underdown, Burger and Whitehead are financially literate as all have experience in reviewing and analysing the financial reports
and ascertaining the financial position of a corporation. Mr. Burger, in his previous position as Chairman and Chief Executive
Officer of AVI Biopharma, is educated and experienced in reading and analyzing financial statements. Mr. Burger has also served
on the audit committee of three other publicly listed biotechnology companies. Dr. Thompson has experience reading and interpreting
financial statements through his role as Chairman and CEO of a publicly listed biotechnology company as well as through his extensive
experience serving on various company boards.  Mr. Underdown, in his position of Managing Director at Lumira Capital Investment
Management, is educated and experienced in reading and analysing financial statements. Mr. Underdown also sits on the board of
directors of several other publicly listed entities. Mr. Whitehead is a CPA (CMA) and has served as the Chief Financial Officer
of Arius Research Inc. and Labopharm Inc. Additionally, we believe that Mr. Underdown, Mr. Thompson, Mr. Whitehead and Mr. Burger
qualify as “independent” as that term is defined in the relevant securities laws relating to the composition of the
audit committee.



Audit Committee Mandate



The Audit Committee’s
mandate is to assist the Board in fulfilling its oversight responsibilities. In particular, the Audit Committee:



| | (a) | serves as an independent and objective party to monitor the integrity of our financial reporting process and systems of internal controls regarding finance, accounting, and legal compliance, including the review of our consolidated financial statements, MD&A and annual and interim results;
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | identifies and monitors the management of the principal risks that could impact our financial reporting;
| | --- | --------------------------------------------------------------------------------------------------------



| | (c) | monitors the independence and performance of our independent auditors, including the pre-approval of all audit fees and all permitted non-audit services;
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | provides an avenue of communication among the independent auditors, management, and our board of directors; and
| | --- | ---------------------------------------------------------------------------------------------------------------



| | (e) | encourages continuous improvement of, and foster adherence to, our policies, procedures and practices at all levels.
| | --- | --------------------------------------------------------------------------------------------------------------------



The Audit Committee is
also responsible for implementing and overseeing our whistle-blowing procedures.



43







|D. | Employees.
|-- | ----------



As at December 31, 2014,
we employed 18 full-time persons and 3 part-time people in research and drug development and administration activities. Among our
employees, 2 hold Ph.Ds, 1 holds a DVM degree and numerous others hold degrees and designations such as MSc, BSc, CPA (CA), CPA
(California) and MBA. To encourage a focus on achieving long-term performance, employees and members of the board of directors
have the ability to acquire an ownership interest in the Company through Aptose’s share option and alternate compensation
plans.



Our ability to develop
commercial products and to establish and maintain our competitive position in light of technological developments will depend,
in part, on our ability to attract and retain qualified personnel. There is a significant level of competition in the marketplace
for such personnel. We believe that to date we have been successful in attracting and retaining the highly skilled personnel critical
to our business. We have also chosen to outsource activities where skills are in short supply or where it is economically prudent
to do so.



None of our employees are
unionized, and we consider our relations with our employees to be good.



|E. | Share ownership.
|-- | ----------------



The following table sets
forth information regarding beneficial ownership of our Common Shares as of December 31, 2014, with respect to our Named Executive
Officers and also with respect to our executive officers and directors individually and as a group.



|                                                    |  |                               |       |  |                                                       |  |     |                                                 |  |  | Options
    to Purchase Common Shares         |  
|--------------------------------------------------- |  | ----------------------------- | ----- |  | ----------------------------------------------------- |  | --- | ----------------------------------------------- |  |  | --------------------------------------------- | -
|                                                    |  | Number
    of  Common  Shares |       |  | Total
    Number of Common  Shares Beneficially Owned |  |     | Percentage
    of  Common Shares Outstanding(+) |  |  | Number
    of  Underlying Common  Shares  (#) |  
|Dr. William Rice                                    |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|Mr. Gregory Chow                                    |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|Mr. Avanish Vellanki                                |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|Dr. Denis Burger                                    |  |                               | 8,499 |  |                                                       |  | -   |                                                 |  |  | 0.1                                           | %
|Dr. Bradley Thompson                                |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|Dr. Erich Platzer                                   |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|Dr. Mark Vincent                                    |  |                               | -     |  |                                                       |  | 500 |                                                 |  |  | 0.0                                           | %
|Mr. Warren Whitehead                                |  |                               | -     |  |                                                       |  | -   |                                                 |  |  | -                                             |  
|                                                    |  |                               |       |  |                                                       |  |     |                                                 |  |  |                                               |  
|All directors and executive
    officers as a group |  |                               | 8,499 |  |                                                       |  | 500 |                                                 |  |  | 0.1                                           | %



(+) calculated on a partially
diluted basis excluding options.



See Item 6.B for a description of arrangements
pursuant to which employees may become involved in the capital of Aptose.



Item 7.	Major Shareholders
and Related Party Transactions



| | A. | Major shareholders.
| | -- | -------------------



To the knowledge of our
directors and officers, as of the date hereof, no person or company beneficially owns, directly or indirectly, or exercises control
or direction over, 5% or more of the outstanding Common Shares, other than those discussed below.



Approximately 63% of our
ordinary Common Shares are held in Canada, and there are 294 record holders of our Common Shares in Canada and 83 record holders
in the United States. All of our shareholders have equal voting rights.



44







The following table is
based upon information supplied by officers, directors and principal Stockholders and Schedules 13D and 13G filed with the SEC.



|Name of Beneficial Owner(s)                |  | Amount and Nature of Beneficial Ownership |           |     | Percent
    of Class(1) | 
|------------------------------------------ |  | ----------------------------------------- | --------- | --- | ----------------------- | 
|Franklin Resources Inc.                    |  |                                           | 1,416,666 | (3) |                         | 
|Cormorant Global Healthcare Master Fund LP |  |                                           | 1,083,333 | (4) |                         | 
|Pinetree Capital                           |  |                                           | 874,300   | (2) |                         | 



(1) Based on 11,767,719 Common Shares
outstanding as of March 3, 2015.



(2) This information is based solely
on a Schedule 13G filed with the SEC on February 13, 2015.



(3) This information is based solely
on a Schedule 13G filed with the SEC on February 6, 2015.



(4) This information is based solely
on a Schedule 13G filed with the SEC on April 14, 2014 and has been adjusted to reflect the 12 to 1 Reverse Stock Split effective
October 1, 2014.



| | B. | Related party transactions.
| | -- | ---------------------------



There were no related party
transactions in the seven month transition period ended December 31, 2014.



Certain related parties
participated in the June 2013 private placement described above. Directors and officers, including former president and chief
operating officer Dr. Aiping Young, former director Dr. Jim Wright and current director Dr. Mark Vincent, acquired an aggregate
of $68,000 of the promissory notes. A company related to Mr. Hebert Abramson, a former director of the Company, acquired $250,000
of the promissory notes and Mr. Inwentash a former related party of the Company by virtue of having exercised control or direction
over more than 10% of the issued and outstanding Common Shares of the Company, acquired $100,000 of the promissory notes. These
promissory notes were repaid by the Company in April 2014.



In the September 2013 convertible
promissory note private placement described above, a company related to Mr. Abramson, a former director of Aptose, acquired $100,000
of the promissory notes; Mr. Inwentash acquired $150,000 of the promissory notes; and Sprott Asset Management, which then held
more than 10% of the Common Shares of Aptose and the ability to acquire control of more than 20% of the Common Shares of Aptose,
acquired $112,000 of the promissory notes.



Mr. Inwentash participated
in the December 2013 Common Share public offering described above and acquired an aggregate of 1,820,000 Common Shares in that
offering and an aggregate of 1,300,000 Common Shares in the April 2014 public offering described above.



Executive Contracts



On October 25, 2013, the
Company entered into an executive employment agreement with William G. Rice, Ph.D., in connection with his appointment as Chief
Executive Officer and Chairman of the Board of the Company. On August 19, 2014, the Company entered into an amended executive
employment agreement with William G. Rice, Ph.D.



On November 29, 2013, the
Company entered into an executive employment agreement with each of Gregory K. Chow and Avanish Vellanki in connection with their
appointments as Chief Financial Officer and Chief Business Officer, respectively, of the Company.



The employment agreements
for each of Dr. Rice, Mr. Chow and Mr. Vellanki provide that if they are terminated by the Company other than for cause, each of
Dr. Rice, Mr. Chow and Mr. Vellanki would be entitled under their respective agreements to a payment equivalent to 12 months of
their respective annual base salaries at the time of termination.  Dr. Rice’s current annual base salary represents
U.S. $480,000, Mr. Chow’s current annual base salary represents U.S. $315,000, and Mr. Vellanki’s current annual base
salary represents U.S. $315,000.  They are each additionally entitled to an amount equal to the average bonus remuneration
received from the Company during the last three years of employment completed prior to the termination date, prorated based on
the number of days the executive worked during the year of the termination.  In addition, the employment agreements for each
of Dr. Rice, Mr. Chow and Mr. Vellanki provide that certain payments related to health benefits continue to be made for a period
of 12 months following termination of their employment.



45







The employment agreements
of each of Dr. Rice, Mr. Chow and Mr. Vellanki also provide for the grant of options to purchase Common Shares of the Company,
at an exercise price equal to the fair market value of the shares on the dates of grant.  In connection with the execution
of his executive employment agreement, Dr. Rice received an initial grant of a fully vested option to purchase 35,417 (425,000
pre-consolidation) Common Shares at an exercise price equal to the fair market value of the Common Shares on the date of grant. 
Pursuant to the terms of his executive employment agreement, upon satisfaction of the conditions in his agreement, Dr. Rice received
additional grants of options to purchase 5,281 (63,367 pre-consolidation), 65,136 (781,633 pre-consolidation) and 140,000 (1,680,000
pre-consolidation) Common Shares on December 10, 2013, January 29, 2014 and April 10, 2014, respectively, at exercise prices equal
to the fair market value of the Common Shares on the dates of grant.  The options vest in accordance with the Company’s
standard three year vesting term, at a rate of 50% of the shares subject to the option vest on the one-year anniversary of the
date of grant and 25% vest on each one-year anniversary thereafter.



In addition to the option
grants to Mr. Chow and Mr. Vellanki described below, Mr. Chow and Mr. Vellanki each received two additional grants of options to
purchase 35,417 (425,000 pre-consolidation) Common Shares pursuant to the terms of their respective executive employment agreements,
on December 10, 2013 and April 10, 2014.  Of the 35,417 (425,000 pre-consolidation) options granted on December 10, 2013 to
Mr. Chow and Mr. Vellanki, 16,667 (200,000 pre-consolidation) vested immediately and the remaining 18,750 (225,000 pre-consolidation)
options vest 50% after one year, 25% after two years and 25% after three years from the date of grant. The options granted in April
10, 2014 vest in equal monthly installments over 36 months from the date of grant.



The employment agreements of Dr. Rice, Mr. Chow
and Mr. Vellanki also provide that, in the event of a change of control (as defined in the agreements), each of Mr. Chow and Mr.
Vellanki would be eligible to receive a payment equivalent to 18 months of their respective annual base salaries at the time of
termination, plus an amount equal to 150% of the average bonus remuneration received from the Company during the last three years
of employment completed prior to the termination date, prorated based on the number of days the executive worked during the year
of the termination, as well as continuation of the payments related to health benefits for a period of 12 months following the
termination following a change of control.



Prior to the Company entering into the executive
employment agreements with Mr. Chow and Mr. Vellanki, Aptose entered into a consulting agreement with each of Mr. Chow and Mr.
Vellanki, on November 4, 2013.  Pursuant to the consulting agreements, Mr. Chow provided services to the Company as acting
Chief Financial Officer prior to the date of his executive employment agreement and Mr. Vellanki provided services as acting Chief
Business Officer prior to the date of his executive employment agreement.  Mr. Chow and Mr. Vellanki each were compensated
at the monthly rate of $20,833 for their services and each were granted a fully vested option to purchase 35,417 (425,000 pre-consolidation)
Common Shares at an exercise price equal to the fair market value of the shares on the date of grant.



| | C. | Interests of experts and counsel.
| | -- | ---------------------------------



Not applicable.



|Item 8. |  | Financial Information
|------- |  | ---------------------



| | A. | Consolidated statements and other financial information.
| | -- | --------------------------------------------------------



See Item 18 for our consolidated
financial statements and other financial information.



46







Dividends on our Common
Shares are declared at the discretion of our board of directors. To date, we have not paid any dividends and do not expect to do
so in the foreseeable future.



|B. | Significant changes.
|-- | --------------------



On January 16, 2015, 108,000
options were granted to members of the Board of Directors and the Scientific Advisory Board of the Company at an exercise price
of $6.77. The options vest over a three year term and have a contractual life of ten years.



On January 20, 2015, $50
thousand of the outstanding convertible promissory notes were converted into 13,888 Common Shares of the Company.



On February 12, 2015, 8,333
outstanding warrants were exercised into an equal number of Common Shares of the Company.



In addition, subsequent
to the seven months ended December 31, 2014 up until the date hereof, 45,625 outstanding options were exercised into an equal number
of Common Shares of the Company.



We announced on January
13, 2015 that we had dosed the first patient in the Phase Ib dose-escalation study. We anticipate providing a potential update
on the dose-escalation study during the summer of 2015, completing enrollment of the Phase Ib dose-escalation study by late-2015
or the first half of 2016, starting the single agent expansion cohort studies for this study in 2016 and starting Phase II combination
studies in 2016.



|Item 9. |  | The Offer and Listing
|------- |  | ---------------------



Not applicable, except for Item 9.A.4. and Item
9.C.



|A. | Offer and listing details.
|-- | --------------------------



Price Range of Common Stock and Trading Markets



Our Common Shares, without
par value, are currently listed on the TSX under the symbol “APS” and NASDAQ under the symbol “APTO.” The
following table sets out the price ranges and trading volumes of our Common Shares on the TSX for the periods indicated below.



|                                        |  | TSX (CDN$ and adjusted for post-consolidation)
|--------------------------------------- |  | ----------------------------------------------
|Five most recent full fiscal years:     |  | High                                          
|Seven Months ended December 31, 2014(1) |  | 9.14                                          
|Year ended May 31, 2014                 |  | 12.48                                         
|Year ended May 31, 2013                 |  | 7.68                                          
|Year ended May 31, 2012                 |  | 8.64                                          
|Year ended May 31, 2011                 |  | 30.60                                         
|Year ended May 31, 2010                 |  | 46.80                                         
|                                        |  |                                               
|Seven months ended December 31, 2014    |  | 9.14                                          
|Three months ended December 31, 2014    |  | 9.14                                          
|Four months ended September 30, 2014    |  | 6.84                                          
|                                        |  |                                               
|Year ended May 31, 2014                 |  | 12.48                                         
|Quarter ended May 31, 2014              |  | 9.24                                          
|Quarter ended February 28, 2014         |  | 10.56                                         
|Quarter ended November 30, 2013         |  | 12.48                                         
|Quarter ended August 31, 2013           |  | 2.88                                          
|                                        |  |                                               
|Year ended May 31, 2013                 |  | 7.68                                          
|Quarter ended May 31, 2013              |  | 3.60                                          
|Quarter ended February 29, 2013         |  | 5.40                                          
|Quarter ended November 30, 2012         |  | 5.76                                          
|Quarter ended August 31, 2012           |  | 7.68                                          
|                                        |  |                                               
|Most recent six months:                 |  |                                               
|February 2015                           |  | 6.64                                          
|January 2015                            |  | 7.20                                          
|December 2014                           |  | 8.30                                          
|November 2014                           |  | 8.50                                          
|October 2014                            |  | 9.14                                          
|September 2014                          |  | 6.84                                          



47







The following table sets
out the price ranges and trading volumes of our Common Shares on NASDAQ following the initial listing on October 23, 2014.



|                                      |  | NASDAQ (US$ and adjusted for post-consolidation)
|------------------------------------- |  | ------------------------------------------------
|Period                                |  | High                                            
|October 23, 2014 to December 31, 2014 |  | 7.75                                            
|December 2014                         |  | 7.29                                            
|November 2014                         |  | 7.40                                            
|October 2014                          |  | 7.75                                            



|B. | Plan of distribution.
|-- | ---------------------



Not applicable.



|C. | Markets.
|-- | --------



See Item 9.A.



|D. | Selling shareholders.
|-- | ---------------------



Not applicable.



|E. | Dilution.
|-- | ---------



Not applicable.



|F. | Expense of the issue.
|-- | ---------------------



Not applicable.



|Item 10. | Additional Information
|-------- | ----------------------



|A. | Share capital.
|-- | --------------



Not applicable.



|B. | Memorandum and articles of association.
|-- | ---------------------------------------



We are incorporated pursuant
to the laws of Canada (Corporation Number: 6650309). Our articles of incorporation(“Articles”) and by-laws
provide no restrictions as to the nature of our business operations. Under Canadian law, a director must inform us, at a meeting
of the Board, of any interest in a material contract or proposed material contract with us. Directors may not vote in respect of
any such contracts made with us or in any such contract in which a director is interested, and such directors shall not be counted
for purposes of determining a quorum. However, these provisions do not apply to (i) a contract relating primarily to their
remuneration as a director, officer, employee or agent of the Corporation or affiliate, (ii) a contract for their indemnity
or insurance as permitted under the Canada Business Corporations Act, or (iii) a contract with an affiliate.



48







We are authorized to issue
an unlimited number of Common Shares. Our shareholders have no rights to share in our profits, are subject to no redemption or
sinking fund provisions, have no liability for further capital calls and are not subject to any discrimination due to number of
Common Shares owned. By not more than 50 days nor less than seven days in advance of a dividend, the Board may establish a
record date for the determination of the persons entitled to such dividend.



The rights of holders of
our Common Shares can be changed at any time in a shareholder meeting where the modifications are approved by 66 2/3% of the Common
Shares represented by proxy or in person at a meeting at which a quorum exists.



All holders of our Common
Shares are entitled to vote at annual or special meetings of shareholders, provided that they were shareholders as of the record
date. The record date for shareholder meetings may precede the meeting date by no more than 50 days and not less than 21 days,
provided that notice by way of advertisement is given to shareholders at least seven days before such record date. Notice of the
time and place of meetings of shareholders may not be less than 21 nor greater than 50 days prior to the date of the meeting.
There are no:



| | · | limitations on share ownership;
| | - | -------------------------------



| | · | provisions of the Articles or by-laws that would have the effect of delaying, deferring or preventing a change of control of our company;
| | - | -----------------------------------------------------------------------------------------------------------------------------------------



| | · | by-law provisions that govern the ownership threshold above which shareholder ownership must be disclosed; and
| | - | --------------------------------------------------------------------------------------------------------------



| | · | conditions imposed by the Articles or by-laws governing changes in capital, but Canadian corporate law requires any changes to the terms of share capital be approved by 66.66% of the Common Shares represented by proxy or in person at a shareholders’ meeting convened for that purpose at which a quorum exists.
| | - | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



Common Shares



Each holder of record of
Common Shares, without par value, is entitled to one vote for each share held on all matters properly submitted to the shareholders
for their vote, except matters which are required to be voted on as a particular class or series of stock. Cumulative voting for
directors is not permitted.



Holders of outstanding
Common Shares are entitled to those dividends declared by the board of directors out of legally available funds. In the event of
liquidation, dissolution or winding up our affairs, holders of Common Shares are entitled to receive, pro rata, our net assets
available after provision has been made for the preferential rights of the holders of preferred stock, including any surplus available
after such event of liquidation, dissolution or winding up of the affairs of the Company. Holders of outstanding Common Shares
have no pre-emptive, conversion or redemption rights. All of the issued and outstanding Common Shares are, and all unissued Common
Shares, when offered and sold will be, duly authorized, validly issued, fully paid and non-assessable. To the extent that additional
Common Shares may be issued in the future, the relative interests of the then existing shareholders may be diluted. There were
11,699,873 Common Shares issued and outstanding at December 31, 2014.



Common Shares Eligible for Future Sale



Future sales of substantial
amounts of our Common Shares in the public market or even the perception that such sales may occur, could adversely affect the
market price for our Common Shares and could impair our future ability to raise capital through an offering of our equity securities.



49







As at March 3, 2015, the Company had 11,767,719
Common Shares issued and outstanding. In addition, as of March 3, 2015 there were 1,436,388 Common Shares issuable upon the exercise
of outstanding options to purchase an equal number of Common Shares at a weighted average price per share of $5.68, 107,640 Common
Shares issuable upon the conversion of outstanding promissory notes and 200,625 Common Shares issuable upon the exercise of Common
Share purchase warrants. Of these warrants 88,438 are priced at $5.40 and expire in August 2016, 39,000 are priced at $3.00 and
expire in June 2015 and 73,198 are priced at $6.60 and expire in December 2015.



Indemnification of Executive Officers and
Directors



We have agreed to indemnify
our executive officers and directors for all costs, charges and expenses, including an amount paid to settle an action or satisfy
a judgment, reasonably incurred by them in respect of any civil, criminal or administrative action or proceeding to which they
are made a party by reason of being or having been a director or officer, if (a) they acted honestly and in good faith with
a view to our best interests, and (b) in the case of a criminal or administrative action or proceeding that is enforced by
a monetary penalty, they had reasonable grounds for believing that their conduct was lawful.



|C. | Material contracts.
|-- | -------------------



Other than
the agreements described below, we have not, in the two years preceding the date hereof, entered into any material agreements other
than contracts in the ordinary course of business.



| | 1. | Lease of premises between the Company and 565991 Ontario Limited, dated July 27, 2001, as amended through March 31, 2015.
| | -- | -------------------------------------------------------------------------------------------------------------------------



| | 2. | Executive Employment Agreement between the Company and Dr. William G. Rice, dated October 25, 2013 and the Amendment dated August 19, 2014.
| | -- | -------------------------------------------------------------------------------------------------------------------------------------------



| | 3. | Executive Employment Agreement between the Company and Gregory K. Chow, dated November 29, 2013.
| | -- | ------------------------------------------------------------------------------------------------



| | 4. | Executive Employment Agreement between the Company and Avanish Vellanki, dated November 29, 2013.
| | -- | -------------------------------------------------------------------------------------------------



| | 5. | Form of Warrant issued in connection with the June 2012 private placement.
| | -- | --------------------------------------------------------------------------



| | 6. | Form of Promissory Note and Warrant Agreement issued June 19, 2013.
| | -- | -------------------------------------------------------------------



| | 7. | Form of Convertible Promissory Note issued September 26, 2013.
| | -- | --------------------------------------------------------------



| | 8. | Underwriting Agreement dated November 22, 2013 in connection with the December 2013 public offering.
| | -- | ----------------------------------------------------------------------------------------------------



| | 9. | Underwriting Agreement dated March 27, 2014 in connection with the April 2014 public offering.
| | -- | ----------------------------------------------------------------------------------------------



Please refer to “Financial
Strategy” for further details on certain agreements referred to in numbers 5 through 9 above and to “Management Contracts”
for further details on items 2 through 4 above.



| | D. | Exchange controls.
| | -- | ------------------



There is no law or governmental
decree or regulation in Canada that restricts the export or import of capital, or affects the remittance of dividends, interest
or other payments to non-resident holders of our voting Common Shares, other than withholding tax requirements.



There is no limitation
imposed by Canadian law or by our Articles or our other charter documents on the right of a non-resident to hold or vote voting
Common Shares, other than as provided by the Investment Canada Act, the North American Free Trade Agreement Implementation
Act (Canada) and the World Trade Organization Agreement Implementation Act.



50







The Investment Canada
Act requires notification and, in certain cases, advance review and approval by the government of Canada of the acquisition
by a non-Canadian of control of a Canadian business, all as defined in the Investment Canada Act. Generally, the threshold
for review will be higher in monetary terms for a member of the World Trade Organization or North American Free Trade Agreement.



|E. | Taxation.
|-- | ---------



CERTAIN UNITED STATES
FEDERAL INCOME TAX CONSIDERATIONS



The following discussion
is limited to certain material U.S. federal income tax considerations relating to the purchase, ownership and disposition of the
Common Shares by U.S. Holders (as defined below). This discussion applies to U.S. Holders that hold Common Shares as capital assets.
This summary is for general information purposes only and does not purport to be a complete analysis or listing of all potential
U.S. federal income tax considerations that may apply to a U.S. Holder arising from and relating to the acquisition, ownership,
and disposition of Common Shares. Accordingly, this summary is not intended to be, and should not be construed as, legal or U.S.
federal income tax advice with respect to any U.S. Holder.



No legal opinion
from U.S. legal counsel or ruling from the Internal Revenue Service (the “IRS”) has been requested, or will be obtained,
regarding the U.S. federal income tax consequences of the acquisition, ownership, and disposition of Common Shares. This summary
is not binding on the IRS, and the IRS is not precluded from taking a position that is different from, and contrary to, the positions
taken in this summary. In addition, because the authorities on which this summary is based are subject to various interpretations,
the IRS and the U.S. courts could disagree with one or more of the conclusions described in this summary.



This discussion
is based on the U.S. Internal Revenue Code of 1986, as amended (the “Code”), U.S. Treasury regulations promulgated
thereunder and administrative and judicial interpretations thereof, all as in effect on the date hereof and all of which are subject
to change, possibly with retroactive effect. This summary does not discuss the potential effects, whether adverse or beneficial,
of any proposed legislation.



This discussion does not address all of the U.S. federal income
tax considerations that may be relevant to specific U.S. Holders in light of their particular circumstances or to U.S. Holders
subject to special treatment under U.S. federal income tax law (such as certain financial institutions, insurance companies, broker-dealers
and traders in securities or other persons that generally mark their securities to market for U.S. federal income tax purposes,
tax-exempt entities, retirement plans, regulated investment companies, real estate investment trusts, certain former citizens or
residents of the United States, persons who hold Common Shares as part of a “straddle,” “hedge,” “conversion
transaction,” “synthetic security” or integrated investment, persons that have a “functional currency”
other than the U.S. dollar, persons that own (or are deemed to own) 10% or more (by voting power or value) of our Common Shares,
corporations that accumulate earnings to avoid U.S. federal income tax, partnerships and other pass-through entities, and investors
in such pass-through entities). This discussion does not address any U.S. state or local or non-U.S. tax considerations or any
U.S. federal estate, gift or alternative minimum tax considerations. In addition, except as specifically set forth below, this
summary does not discuss applicable tax reporting requirements.



As used in this discussion,
the term “U.S. Holder” means a beneficial owner of the Common Shares that is, for U.S. federal income tax purposes,
(1) an individual who is a citizen or resident of the United States, (2) a corporation (or entity treated as a corporation
for U.S. federal income tax purposes) created or organized in or under the laws of the United States, any state thereof, or the
District of Columbia, (3) an estate the income of which is subject to U.S. federal income tax regardless of its source or
(4) a trust (x) with respect to which a court within the United States is able to exercise primary supervision over its
administration and one or more United States persons have the authority to control all of its substantial decisions or (y) that
has elected under applicable U.S. Treasury regulations to be treated as a domestic trust for U.S. federal income tax purposes.



51







If an entity treated as
a partnership for U.S. federal income tax purposes holds the Common Shares, the U.S. federal income tax considerations relating
to an investment in the Common Shares will depend in part upon the status and activities of such entity and the particular partner.
Any such entity should consult its own tax advisor regarding the U.S. federal income tax considerations applicable to it and its
partners of the purchase, ownership and disposition of the Common Shares.



Persons holding Common Shares should consult their own tax advisors
as to the particular tax considerations applicable to them relating to the purchase, ownership and disposition of Common Shares,
including the applicability of U.S. federal, state and local tax laws and non-U.S. tax laws.



Distributions



Subject to the discussion
below under “Passive Foreign Investment Company Considerations,” a U.S. Holder that receives a distribution with respect
to the Common Shares generally will be required to include the gross amount of such distribution (before reduction for any Canadian
withholding taxes) in gross income as a dividend when actually or constructively received to the extent of the U.S. Holder’s
pro rata share of our current and/or accumulated earnings and profits (as determined under U.S. federal income tax principles).
To the extent a distribution received by a U.S. Holder is not a dividend because it exceeds the U.S. Holder’s pro rata share
of our current and accumulated earnings and profits, it will be treated first as a tax-free return of capital and reduce (but not
below zero) the adjusted tax basis of the U.S. Holder’s Common Shares. To the extent the distribution exceeds the adjusted
tax basis of the U.S. Holder’s Common Shares, the remainder will be taxed as capital gain. Because we may not calculate our
earnings and profits under U.S. federal income tax principles, U.S. Holders should expect all distributions to be reported to them
as dividends.



The U.S. dollar value of
any distribution on the Common Shares made in Canadian dollars generally should be calculated by reference to the exchange rate
between the U.S. dollar and the Canadian dollar in effect on the date of receipt (or deemed receipt) of such distribution by the
U.S. Holder regardless of whether the Canadian dollars so received are in fact converted into U.S. dollars at that time. If the
Canadian dollars received are converted into U.S. dollars on the date of receipt (or deemed receipt), a U.S. Holder generally should
not recognize currency gain or loss on such conversion. If the Canadian dollars received are not converted into U.S. dollars on
the date of receipt (or deemed receipt), a U.S. Holder generally will have a basis in such Canadian dollars equal to the U.S. dollar
value of such Canadian dollars on the date of receipt (or deemed receipt). Any gain or loss on a subsequent conversion or other
disposition of such Canadian dollars by such U.S. Holder generally will be treated as ordinary income or loss and generally will
be income or loss from sources within the United States for U.S. foreign tax credit purposes. Different rules apply to U.S. Holders
who use the accrual method with respect to foreign currency received upon the sale, exchange or other taxable disposition of the
Common Shares. Each U.S. Holder should consult its own U.S. tax advisors regarding the U.S. federal income tax consequences of
receiving, owning, and disposing of foreign currency.



Distributions on the Common
Shares that are treated as dividends generally will constitute income from sources outside the United States for foreign tax credit
purposes and generally will constitute passive category income. Such dividends will not be eligible for the “dividends received”
deduction generally allowed to corporate shareholders with respect to dividends received from U.S. corporations. Dividends paid
by a “qualified foreign corporation” are eligible for taxation at a reduced capital gains rate rather than the marginal
tax rates generally applicable to ordinary income provided that a holding period requirement (more than 60 days of ownership, without
protection from the risk of loss, during the 121-day period beginning 60 days before the ex-dividend date) and certain other requirements
are met. However, if we are a PFIC for the taxable year in which the dividend is paid or the preceding taxable year (see discussion
below under “—Passive Foreign Investment Company Considerations”), we will not be treated as a qualified foreign
corporation, and therefore the reduced capital gains tax rate described above will not apply. Each U.S. Holder is advised to consult
its tax advisors regarding the availability of the reduced tax rate on dividends.



If a U.S. Holder is subject
to Canadian withholding tax on dividends paid on the holder’s Common Shares, the U.S. Holder may be eligible, subject to
a number of complex limitations, to claim a credit against its U.S. federal income tax for the Canadian withholding tax imposed
on the dividends. A U.S. Holder may claim a deduction for the Canadian withholding tax in lieu of a credit, but only for a year
in which the U.S. Holder elects to do so for all creditable foreign income taxes. The rules governing the foreign tax credit are
complex. Each U.S. Holder is advised to consult its tax advisor regarding the availability of the foreign tax credit under its
particular circumstances.



52







Sale, Exchange or Other Disposition of Common Shares



Subject to the discussion
below under “Passive Foreign Investment Company Considerations,” a U.S. Holder generally will recognize capital gain
or loss for U.S. federal income tax purposes upon the sale, exchange or other disposition of Common Shares. The amount of gain
recognized will equal the excess of the amount realized (i.e., the amount of cash plus the fair market value of any property
received) over the U.S. Holder’s adjusted tax basis in the Common Shares sold or exchanged. The amount of loss recognized
will equal the excess of the U.S. Holder’s adjusted tax basis in the Common Shares sold or exchanged over the amount realized.
Such capital gain or loss generally will be long-term capital gain or loss if, on the date of sale, exchange or other disposition,
the Common Shares were held by the U.S. Holder for more than one year. Net long-term capital gain derived by a non-corporate U.S.
Holder currently is subject to tax at reduced rates. The deductibility of a capital loss is subject to limitations. Any gain or
loss recognized from the sale, exchange or other disposition of Common Shares will generally be gain or loss from sources within
the United States for U.S. foreign tax credit purposes.



Passive Foreign Investment Company Considerations



In general, a corporation
organized outside the United States will be treated as a PFIC in any taxable year in which either (1) at least 75% of its
gross income is “passive income” or (2) at least 50% of the average quarterly value of its assets is attributable
to assets that produce passive income or are held for the production of passive income. Passive income for this purpose generally
includes, among other things, dividends, interest, royalties, rents, and gains from commodities transactions and from the sale
or exchange of property that gives rise to passive income. In determining whether a foreign corporation is a PFIC, a proportionate
share of the items of gross income and assets of each corporation in which it owns, directly or indirectly, at least a 25% interest
(by value) are taken into account.



We believe we were a PFIC
for our taxable year ended December 31, 2014. Based on the nature of our business, the projected composition of our gross income
and the projected composition and estimated fair market values of our assets, we expect to be a PFIC for our taxable year ending
December 31, 2015 and may be a PFIC in subsequent tax years. However, the determination of our PFIC status is made annually after
the close of each taxable year and it is difficult to predict before such determination whether we will be a PFIC for any given
taxable year. Even if we determine that we are not a PFIC after the close of a taxable year, there can be no assurance that the
Internal Revenue Service (the “IRS”) will agree with our conclusion. No assurance can be provided regarded our
PFIC status, and neither we nor our United States counsel expresses any opinion with respect to our PFIC status for the taxable
year ended December 31, 2014 or for any other taxable year.



If we are a PFIC at any
time when a U.S. Holder owns Common Shares, such U.S. Holder will generally be subject to federal tax under the excess distribution
regime on (1) distributions paid during a taxable year that are greater than 125% of the average annual distributions
paid in the three preceding taxable years, or, if shorter, the U.S. Holder’s holding period for the Common Shares, and (2) any
gain recognized on a sale, exchange or other disposition (which would include a pledge) of Common Shares. Under the excess distribution
regime, the U.S. Holder’s tax liability will be determined by allocating such distribution or gain ratably to each day in
the U.S. Holder’s holding period for the Common Shares. The amount allocated to the current taxable year (i.e., the
year in which the distribution occurs or the gain is recognized) and any year prior to the first taxable year in which we were
a PFIC in the holding period will be taxed as ordinary income earned in the current taxable year. The amount allocated to other
taxable years will be taxed at the highest marginal rate in effect (for individuals or corporations as applicable) for ordinary
income in each such taxable year, and an interest charge, generally that applicable to the underpayment of tax, will be added to
the tax. Once we are a PFIC with respect to a particular U.S. Holder, we generally will remain a PFIC with respect to the U.S.
Holder, unless we cease to meet the gross income and asset tests described above and the U.S. Holder makes a “deemed sale”
election with respect to all of the U.S. Holder’s Common Shares. If such election is made, the U.S. Holder will be deemed
to have sold the Common Shares held at their fair market value on the last day of the last taxable year in which we qualified as
a PFIC, and any gain from such deemed sale would be taxed under the excess distribution regime described above. After the deemed
sale election, the U.S. Holder’s Common Shares would not be treated as Common Shares of a PFIC unless we subsequently became
a PFIC.



53







If we are a PFIC for any
taxable year during which a U.S. Holder holds the Common Shares and one of our non-United States subsidiaries is also a PFIC (i.e.,
a lower-tier PFIC), the U.S. Holder will be treated as owning a proportionate amount (by value) of the Common Shares of the lower-tier
PFIC and will be subject to the rules described above on certain distributions by the lower-tier PFIC and a disposition (or deemed
disposition) of Common Shares of the lower-tier PFIC, even though the U.S. Holder would not receive the distributions or the proceeds
from the disposition of the Common Shares of the lower-tier PFIC. Each U.S. Holder is advised to consult its tax advisors regarding
the application of the PFIC rules to any of our subsidiaries.



The tax considerations
that would apply if we were a PFIC would be different from those described above if a U.S. Holder were able to make a valid “qualified
electing fund,” or “QEF election.” We do not intend to provide U.S. Holders with the information required to
permit them to make a QEF election and, accordingly, prospective investors should assume that a QEF election will not be available.



A U.S. Holder may avoid
taxation under the excess distribution regime if the holder makes a valid “mark-to-market” election. An electing U.S.
Holder generally would take into account as ordinary income each year, the excess of the fair market value of the Common Shares
held at the end of the taxable year over the adjusted tax basis of such Common Shares. The U.S. Holder would also take into account,
as an ordinary loss each year, the excess of the adjusted tax basis of such Common Shares over their fair market value at the end
of the taxable year, but only to the extent of the excess of amounts previously included in income over ordinary losses deducted
as a result of the mark-to-market election. The U.S. Holder’s tax basis in the Common Shares would be adjusted to reflect
any income or loss recognized as a result of the mark-to-market election. Any gain from a sale, exchange or other disposition of
the Common Shares in any taxable year in which we are a PFIC, (i.e., when we meet the gross income test or asset test described
above) would be treated as ordinary income and any loss from a sale, exchange or other disposition would be treated first as an
ordinary loss (to the extent of any net mark-to-market gains previously included in income) and thereafter as a capital loss. If
we cease to be a PFIC, any gain or loss recognized by a U.S. Holder on the sale or exchange of the Common Shares would be classified
as a capital gain or loss.



A mark-to-market election
is available to a U.S. Holder only for “marketable stock.” Generally, stock will be considered marketable stock if
it is “regularly traded” on a “qualified exchange” within the meaning of applicable U.S. Treasury regulations.
A class of stock is regularly traded during any calendar year during which such class of stock is traded, other than in de minimis
quantities, on at least 15 days during each calendar quarter. The Common Shares should be marketable stock as long as they
are listed on the TSX and are regularly traded. A mark-to-market election will not apply to the Common Shares for any taxable year
during which we are not a PFIC, but will remain in effect with respect to any subsequent taxable year in which we again become
a PFIC. Such election will not apply to any subsidiary that we own. Accordingly, a U.S. Holder may continue to be subject to the
PFIC rules with respect to any lower-tier PFICs notwithstanding the U.S. Holder’s mark-to-market election.



Each U.S. person who is
a shareholder of a PFIC generally must file an annual report with the IRS containing certain information, and the failure to file
such report could result in the imposition of penalties on such U.S. person and in the extension of the statute of limitations
with respect to federal income tax returns filed by such U.S. person.



The U.S. federal income tax rules relating to PFICs are very
complex. U.S. Holders are urged to consult their own tax advisers with respect to the purchase, ownership and disposition of Common
Shares, the consequences to them of an investment in a PFIC, any elections available with respect to the Common Shares and the
IRS information reporting obligations with respect to the purchase, ownership and disposition of Common Shares in the event we
are considered a PFIC.



Medicare Tax



Certain U.S. Holders
that are individuals, estates or trusts (other than trusts that are exempt from tax) will be subject to a 3.8% tax on all or a
portion of their “net investment income,” which includes dividends on the Common Shares, and net gains from the disposition
of the Common Shares. Further, excess distributions treated as dividends, gains treated as excess distributions, and mark-to-market
inclusions and deductions are all included in the calculation of net investment income.



54







Treasury regulations provide,
subject to the election described in the following paragraph, that solely for purposes of this additional tax, that distributions
of previously taxed income will be treated as dividends and included in net investment income subject to the additional 3.8% tax.
Additionally, to determine the amount of any capital gain from the sale or other taxable disposition of Common Shares that will
be subject to the additional tax on net investment income, a U.S. Holder who has made a QEF election will be required to recalculate
its basis in the Common Shares excluding QEF election basis adjustments.



Alternatively, a U.S. Holder
may make an election which will be effective with respect to all interests in controlled foreign corporations and QEF election
held in that year or acquired in future years. Under this election, a U.S. Holder pays the additional 3.8% tax on QEF election
income inclusions and on gains calculated after giving effect to related tax basis adjustments. U.S. Holders that are individuals,
estates or trusts should consult their own tax advisors regarding the applicability of this tax to any of their income or gains
in respect of the Common Shares.



Information Reporting with Respect to Foreign Financial Assets



U.S. individuals that own
“specified foreign financial assets” with an aggregate fair market value exceeding either US$50,000 on the last day
of the taxable year or US$75,000 at any time during the taxable year generally are required to file an information report on IRS
Form 8938 with respect to such assets with their tax returns. Significant penalties may apply to persons who fail to comply with
these rules. Specified foreign financial assets include not only financial accounts maintained in foreign financial institutions,
but also, unless held in accounts maintained by a financial institution, any stock or security issued by a non-U.S. person. Upon
the issuance of future U.S. Treasury regulations, these information reporting requirements may apply to certain U.S. entities that
own specified foreign financial assets. The failure to report information required under the current regulations could result in
substantial penalties and in the extension of the statute of limitations with respect to federal income tax returns filed by a
U.S. Holder. U.S. Holders should consult their own tax advisors regarding the possible implications of these U.S. Treasury regulations
for an investment in our Common Shares.



Special Reporting Requirements for Transfers to Foreign Corporations



A U.S. Holder that acquires
Common Shares generally will be required to file Form 926 with the IRS if (1) immediately after the acquisition such U.S. Holder,
directly or indirectly, owns at least 10% of the Common Shares, or (2) the amount of cash transferred in exchange for Common Shares
during the 12-month period ending on the date of the acquisition exceeds US$100,000. Significant penalties may apply for failing
to satisfy these filing requirements. U.S. Holders are urged to contact their tax advisors regarding these filing requirements.



Information Reporting and Backup Withholding



Dividends on and proceeds
from the sale or other disposition of Common Shares may be reported to the IRS unless the U.S. Holder establishes a basis for exemption.
Backup withholding may apply to amounts subject to reporting if (1) the holder fails to provide an accurate taxpayer identification
number or otherwise establish a basis for exemption, or (2) is described in certain other categories of persons.



Backup withholding is not
an additional tax. Any amounts withheld under the backup withholding rules generally will be allowed as a refund or a credit against
a U.S. Holder’s U.S. federal income tax liability if the required information is furnished by the U.S. Holder on a timely
basis to the IRS.



THE DISCUSSION ABOVE IS A GENERAL SUMMARY.
IT DOES NOT COVER ALL TAX MATTERS THAT MAY BE OF IMPORTANCE TO A US HOLDER. EACH US HOLDER IS URGED TO CONSULT ITS OWN TAX ADVISOR
ABOUT THE TAX CONSEQUENCES TO IT OF AN INVESTMENT IN COMMON SHARES IN LIGHT OF THE INVESTOR’S OWN CIRCUMSTANCES.



55







CERTAIN CANADIAN FEDERAL INCOME TAX CONSIDERATIONS



The following is, as of
the date hereof, a summary of the principal Canadian federal income tax considerations under the Income Tax Act (Canada)
(the “Tax Act”) generally applicable to a holder of Common Shares of the Company who, for purposes of the Tax
Act and at all relevant times, is neither resident in Canada nor deemed to be resident in Canada for purposes of the Tax Act and
any applicable income tax treaty or convention, and who does not use or hold (and is not deemed to use or hold) Common Shares in
carrying on a business in Canada, deals at arm’s length with and is not affiliated with the Company and holds Common Shares
as capital property (a “Holder”). Generally, Common Shares will be considered to be capital property to a Holder
thereof provided that the Holder does not hold Common Shares in the course of carrying on a business of buying and selling securities
and such Holder has not acquired them in one or more transactions considered to be an adventure or concern in the nature of trade.



This summary does not apply
to a Holder (i) that is a “financial institution” for purposes of the mark-to-market rules contained in the Tax Act;
(ii) that is a “specified financial institution” as defined in the Tax Act; (iii) an interest in which is a “tax
shelter investment” as defined in the Tax Act; or (iv) that has elected to report its tax results in a functional currency
other than Canadian currency. Special rules, which are not discussed in this summary, may apply to a Holder that is an “authorized
foreign bank” within the meaning of the Tax Act or an insurer carrying on business in Canada and elsewhere. Such Holders
should consult their own tax advisors.



This summary is based upon
the provisions of the Tax Act (including the regulations (“Regulations”) thereunder) in force as of the date
hereof and our understanding of the current administrative policies and assessing practices of the Canada Revenue Agency (the “CRA”)
published in writing by the CRA prior to the date hereof. This summary takes into account all specific proposals to amend the Tax
Act (and the Regulations) publicly announced by or on behalf of the Minister of Finance (Canada) prior to the date hereof (the
“Tax Proposals”) and assumes that the Tax Proposals will be enacted in the form proposed, although no assurance
can be given that the Tax Proposals will be enacted in their current form or at all. This summary does not otherwise take into
account any changes in law or in the administrative policies or assessing practices of the CRA, whether by legislative, governmental
or judicial decision or action. This summary is not exhaustive of all possible Canadian federal income tax considerations, and
does not take into account other federal or any provincial, territorial or foreign income tax legislation or considerations, which
may differ materially from those described in this summary.



This summary is of a general
nature only and is not, and is not intended to be, and should not be construed to be, legal or tax advice to any particular Holder,
and no representations concerning the tax consequences to any particular Holder are made. Holders should consult their own tax
advisors regarding the income tax considerations applicable to them having regard to their particular circumstances.



Dividends



Dividends paid or credited
(or deemed to be paid or credited) to a Holder by the Company are subject to Canadian withholding tax at the rate of 25% unless
reduced by the terms of an applicable tax treaty. For example, under the Canada-United States Income Tax Convention (1980) (the
“US Treaty”), as amended, the dividend withholding tax rate is generally reduced to 15% in respect of
a dividend paid or credited to a Holder beneficially entitled to the dividend who is resident in the U.S. for purposes of the US
Treaty and whose entitlement to the benefits of the US Treaty is not limited by the limitation of benefits provisions of the US
Treaty. Holders are urged to consult their own tax advisors to determine their entitlement to relief under the US Treaty or any
other applicable tax treaty as well as their ability to claim foreign tax credits with respect to any Canadian withholding tax,
based on their particular circumstances.



Disposition of Common
Shares



A Holder generally will
not be subject to tax under the Tax Act in respect of a capital gain realized on the disposition or deemed disposition of a Common
Share, unless the Common Share constitutes or is deemed to constitute “taxable Canadian property” to the Holder thereof
for purposes of the Tax Act, and the gain is not exempt from tax pursuant to the terms of an applicable tax treaty or convention.



56







In general, provided the
Common Shares are listed on a “designated stock exchange” (which currently includes the TSX) at the date of the disposition,
the Common Shares will only constitute “taxable Canadian property” of a Holder if, at any time within the 60-month
period preceding the disposition: (i) such Holder, persons with whom the Holder did not deal at arm's length, partnerships in which
the Holder or a person with whom the Holder did not deal at arm’s length holds a membership interest directly or indirectly
through one or more partnerships, or any combination thereof, owned 25% or more of the issued shares of any class or series of
the Company’s capital stock, and (ii) more than 50% of the fair market value of the Common Shares was derived directly or
indirectly from one or any combination of (A) real or immovable property situated in Canada, (B) Canadian resource properties,
(C) timber resource properties, and (D) options in respect of, or interests in, or for civil law rights in, property described
in any of subparagraphs (ii)(A) to (C), whether or not the property exists. However, and despite the foregoing, in certain circumstances
the Common Shares may be deemed to be “taxable Canadian property” under the Tax Act.



Holders whose Common Shares
may be “taxable Canadian property” should consult their own tax advisers.



|F. | Dividends and paying agents.
|-- | ----------------------------



Not applicable.



|G. | Statement by experts.
|-- | ---------------------



Not applicable.



|H. | Documents on display.
|-- | ---------------------



We are subject to the information
and reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and file
periodic reports and other information with the SEC. However, as a foreign private issuer, we are exempt from the rules and regulations
under the Exchange Act prescribing the furnishing and content of proxy statements, and our officers, directors and principal shareholders
are exempt from the reporting and short-swing profit recovery provisions contained in Section 16 of the Exchange Act. Our
reports and other information filed with the SEC may be inspected at the public reference facilities maintained by the SEC at 100
F Street, N.E., Washington, D.C. 20549. Copies of these materials may be obtained at prescribed rates from the SEC at that address.
Our reports and other information can also be inspected at no charge on the SEC’s website at www.sec.gov.



We are also subject to
the information and reporting requirements of the Securities Act (Ontario) and the Canada Business Corporations Act.
Such reports and information can be inspected at no charge on the website www.sedar.com.



If you are a shareholder,
you may request a copy of these filings at no cost by contacting us at:



Director of Finance
Aptose Biosciences Inc.
2 Meridian Road
Toronto, Ontario M9W 4Z7
Canada
Phone (416) 798-1200
Fax (416) 798-2200



|I. | Subsidiary information.
|-- | -----------------------



Aptose has two subsidiaries:
NuChem, a company incorporated under the laws of Ontario, Canada, and Aptose USA, a company incorporated under the laws of Delaware,
USA. Aptose owns 80% of the issued and outstanding voting share capital of NuChem and 100% of the issued and outstanding voting
share capital of Aptose USA. NuChem has limited activity and the non-controlling interest is not material to the consolidated financial
statements of the Company. Aptose USA was incorporated in April 2014 and did not have any activity during the transition period
ended December 31, 2014.



57







|Item 11. | Qualitative and Quantitative Disclosures About Market Risk
|-------- | ----------------------------------------------------------



Refer to notes 4 and 8
to the consolidated financial statements contained in Item 18.



We are not exposed to significant
market risks. We do not currently have significant interest, credit or foreign currency risk.



We do not utilize derivative
financial instruments to hedge our interest rate or foreign currency rate risks.



Interest Rate Risk



The Company invests its
cash resources in liquid government and corporate debt instruments. We do not believe that the results of operations or cash flows
would be affected to any significant degree by a sudden change in market interest rates relative to interest rates on our investments,
owing to the relative short-term nature of the investments.



Credit Risk



Financial instruments potentially
exposing the Company to a concentration of credit risk consist principally of cash and cash equivalents and marketable securities.
The Company manages this credit risk by maintaining bank accounts with Schedule I banks and investing only in highly rated Canadian
securities that are traded on active markets and are capable of prompt liquidation.



Exchange Rate Sensitivity



The functional currency
of the Company is the Canadian dollar. The Company does not have significant cash balances in any foreign currencies, does not
generally invest in marketable securities denominated in currencies other than Canadian dollars and does not have revenue sources
denominated in foreign currencies as of December 31, 2014. The Company has employment contracts, including Executive employment
contracts which are denominated in U.S. dollars as well as contracts to provide clinical trial services which are denominated in
U.S. dollars. A decrease in the value of the Canadian dollar increases the costs associated with these contracts. Any foreign exchange
gains and losses are included in the determination of gain or loss for the relevant period.



Limitations



The above discussion includes
only those exposures that exist as of December 31, 2014, and as a result, does not consider exposures or positions that could arise
after that date. The Company’s ultimate realized gain or loss with respect to interest rate and exchange rate fluctuations
would depend on the exposures that arise during the period.



Risk Factors



See Item 3.D.



|Item 12. | Description of Securities Other Than Equity Securities
|-------- | ------------------------------------------------------



Not applicable.



58







PART II



|Item 13. | Defaults, Dividends Arrearages and Delinquencies
|-------- | ------------------------------------------------



Not applicable.



|Item 14. | Material Modifications to the Rights of Security Holders and Use of Proceeds
|-------- | ----------------------------------------------------------------------------



Not applicable.



|Item 15. | Controls and Procedures
|-------- | -----------------------



|(a) | Disclosure controls and procedures.
|--- | -----------------------------------



As of the end of the seven
months ended December 31, 2014, an evaluation of the effectiveness of our “disclosure controls and procedures” (as
such term is defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act), was carried out by our management under the supervision
of and with the participation of the principal executive officer and principal financial officer. Based upon on that evaluation,
our principal executive officer and principal financial officer have concluded that as of the end of that transition period, our
disclosure controls and procedures were effective to ensure that information required to be disclosed by us in reports that we
file or submit under the Exchange Act is (i) recorded, processed, summarized and reported within the time periods specified in
SEC rules and forms and (ii) accumulated and communicated to our management, including our principal executive officer and principal
financial officer, to allow timely decisions regarding required disclosure.



It should be noted that
while our principal executive officer and principal financial officer believe that our disclosure controls and procedures are effective
and provide a reasonable level of assurance, they do not expect that the disclosure controls and procedures or internal control
over financial reporting will prevent all errors and fraud. A control system, no matter how well conceived or operated, can provide
only reasonable, not absolute, assurance that the objectives of the control system are met.



|(b) | Management’s annual report on internal control over financial reporting.
|--- | ------------------------------------------------------------------------



Management is responsible
for establishing and maintaining adequate internal control over our financial reporting (as such term is defined in Rules 13a-15(f)
and 15d-15(f) under the Exchange Act). Our internal control system was designed to provide reasonable assurance that all transactions
are accurately recorded, that transactions are recorded as necessary to permit preparation of consolidated financial statements
in accordance with IFRS, and that our assets are safeguarded.



Management has assessed
the effectiveness of our internal control over financial reporting as at December 31, 2014. In management’s opinion,
our internal control over financial reporting is effective as of December 31, 2014. In making its assessment, management used
the Committee of Sponsoring Organizations of the Treadway Commission framework in Internal Control – Integrated Framework
of 1992 to evaluate the effectiveness of our internal control over financial reporting.



The design of any system
of controls and procedures is based in part upon certain assumptions about the likelihood of future events. There can be no assurance
that any design will succeed in achieving its stated goals under all potential future conditions, regardless of how remote.



|(c) | Attestation report of the independent registered public accounting firm.
|--- | ------------------------------------------------------------------------



Because we are a non-accelerated
filer under the rules of the SEC, this Transition Report is not required to include, and does not include, an attestation report
of our independent registered public accounting firm with respect to our internal control over financial reporting.



59







|(d) | Changes in internal control over financial reporting.
|--- | -----------------------------------------------------



There has been no change in our internal control
over financial reporting during the period covered by this Transition Report that has materially affected, or is reasonably likely
to materially affect, our internal control over financial reporting.



|Item 16. | [Reserved]
|-------- | ----------



|Item 16A. | Audit Committee Financial Expert
|--------- | --------------------------------



Our board of directors
has determined that Mr. Warren Whitehead, a director of the Company and the chairman of the Audit Committee, possesses the attributes
required of an “audit committee financial expert,” and is “independent,” within the meaning of applicable
NASDAQ rules.



|Item 16B. | Code of Ethics
|--------- | --------------



We have adopted a code
of ethics, as such term is defined in Form 20-F, which applies to all of our officers, directors, employees and consultants. A
copy of the code of ethics is available, without charge, upon written request from our Director of Finance at our offices located
at 2 Meridian Road, Toronto, Ontario M9W 4Z7, Canada. There were no amendments to, or waivers granted under, our code of ethics
during the seven months ended December 31, 2014.



|Item 16C. | Principal Accountant Fees and Services
|--------- | --------------------------------------



KPMG LLP has served as
our principal independent external auditor since October 1994. The total fees billed to us for professional services provided by
KPMG LLP for the seven months ended December 31, 2014 and the fiscal year ended May 31, 2014 are as follows:



|                   |  | Seven Months Ended December 31, 2014 |         |  | Fiscal Year Ended May 31, 2014 |  
|------------------ |  | ------------------------------------ | ------- |  | ------------------------------ | -
|Audit Fees         |  | $                                    | 157,440 |  |                                | $
|Audit-Related Fees |  | $                                    | -       |  |                                | $
|Tax Fees           |  | $                                    | 36,015  |  |                                | $
|All Other Fees     |  | $                                    | -       |  |                                | $
|Total              |  | $                                    | 193,455 |  |                                | $



Audit fees consist of the
fees paid with respect to the audit of our consolidated annual financial statements, quarterly reviews and 20-F filing with the
SEC and for any other professional services that are normally provided by KPMG LLP in connection with statutory and regulatory
filings or engagements. Tax fees related to tax planning advice provided with respect to intellectual property and US operations.



Pre-Approval Policies and Procedures



The Audit Committee of
our board of directors has, pursuant to the Audit Committee charter, adopted specific responsibilities and duties regarding the
provision of services by our external auditor, currently KPMG LLP. Our charter requires Audit Committee pre-approval of all permitted
audit, audit-related and tax services.



Subject to the charter,
the Audit Committee may establish fee thresholds for a group of pre-approved services. The Audit Committee then recommends to the
board of directors approval of the fees and other significant compensation to be paid to the independent auditors.



No services were provided
by KPMG LLP under a de minimusexemption for the seven months ended December 31, 2014.



60







|Item 16D. | Exemptions from the Listing Standards for Audit Committees
|--------- | ----------------------------------------------------------



Not applicable.



|Item 16E. | Purchases of Equity Securities by the Issuer and Affiliated Purchasers
|--------- | ----------------------------------------------------------------------



Not applicable.



|Item 16F. | Change in Registrant’s Certifying Accountant
|--------- | --------------------------------------------



Not applicable.



|Item 16G. | Corporate Governance
|--------- | --------------------



On October 23, 2014, we listed our Common Shares
for trading on NASDAQ.  Section 5615(a)(3) of the NASDAQ Marketplace Rules permits NASDAQ to grant exemptions to a foreign
private issuer for the provisions of the Rule 5600 series and Rule 5250 (d).  We are organized under the laws of Canada
and our Common Shares are listed for trading on the TSX.  We comply with the laws of Canada and rules and regulations
of the TSX, including rules related to corporate governance practices.  A description of the significant ways in which
our governance practices differ from those followed by domestic companies pursuant to the NASDAQ Marketplace Rules is as follows:



Shareholder Meeting Quorum Requirement:The
NASDAQ minimum quorum requirement for a shareholder meeting under Section 5620(c) of the NASDAQ Marketplace Rules is one-third
of the outstanding shares of common stock.  In addition, a company listed on NASDAQ is required to state a quorum requirement
in their bylaws.  Our quorum requirement is set forth in our corporate bylaws.  A quorum for our shareholder
meeting is two persons present or by means of a telephonic, electronic or other communication facility that permits all participants
to communicate adequately with each other during the meeting and each entitled to vote at the meeting.



Compensation Committee Mandate: NASDAQ
will require compliance with the revised Rule 5605(d) for all companies following the company's first annual meeting occurring
after January 15, 2014, or October 31, 2014, whichever is earlier. In our case this would be following our August 19, 2014 annual
general and special meeting. The changes to the rule include requiring the mandate of the Compensation Committee to include accountability
to external advisors. The Compensation Committee Mandate does not currently include such requirements.



The foregoing is consistent with the laws,
customs and practices in Canada and the rules of the TSX.



|Item 16H. | Mine Safety Disclosure
|--------- | ----------------------



Not applicable.



61







PART III



|Item 17. | Financial Statements
|-------- | --------------------



We have responded to Item 18 in lieu of responding
to this Item.



|Item 18. | Financial Statements
|-------- | --------------------



The consolidated financial statements of Aptose
Biosciences Inc. are attached as follows:



|                                                                                                                                             |  | Page
|-------------------------------------------------------------------------------------------------------------------------------------------- |  | ----
|Management’s Responsibility for Financial Reporting                                                                                          |  | F-1 
|                                                                                                                                             |  |     
|Independent Auditors’ Report of Registered Public Accounting Firm                                                                            |  | F-3 
|                                                                                                                                             |  |     
|Consolidated Statements of Financial Position as at December 31, 2014 and May 31, 2014                                                       |  | F-4 
|                                                                                                                                             |  |     
|Consolidated Statements of Loss and Comprehensive Loss for the seven months ended December 31, 2014 and years ended May 31, 2014 and 2013    |  | F-5 
|                                                                                                                                             |  |     
|Consolidated Statement of Changes in Shareholders’ Equity for the seven months ended December 31, 2014 and years ended May 31, 2014 and 2013 |  | F-6 
|                                                                                                                                             |  |     
|Consolidated Statements of Cash Flows for the seven months ended December 31, 2014 and years ended May 31, 2014 and 2013                     |  | F-8 
|                                                                                                                                             |  |     
|Notes to Consolidated Financial Statements for the seven months ended December 31, 2014 and years ended May 31, 2014 and 2013                |  | F-9 



62







|Item 19. | Exhibits.
|-------- | ---------



See the Exhibit Index below.



63







SIGNATURES



The registrant hereby certifies that it meets
all of the requirements for filing on Form 20-F and that it has duly caused and authorized the undersigned to sign this Transition
Report on its behalf.



| |     | APTOSE BIOSCIENCES INC.                        
| | --- | -----------------------------------------------
| |     |                                                
| | By: | /s/ William G. Rice                            
| |     | Name:   William G. Rice, PhD                   
| |     | Title:     Chairman and Chief Executive Officer
| |     |                                                
| |     | Date:     March 3, 2015                        



| | By: | /s/ Gregory K. Chow               
| | --- | ----------------------------------
| |     | Name:   Gregory K. Chow           
| |     | Title:     Chief Financial Officer
| |     |                                   
| |     | Date:     March 3, 2015           



64







EXHIBIT INDEX



|Exhibit 
Number   |  | Description                                                                                                              
|----------------- |  | -------------------------------------------------------------------------------------------------------------------------
|1.1*              |  | Articles of Incorporation                                                                                                
|1.2*              |  | Articles of Arrangement                                                                                                  
|1.3^^^            |  | Certificate of Amendment                                                                                                 
|1.4*              |  | By-law #2 of the Registrant                                                                                              
|2.11+             |  | Indemnification Agreement dated July 10, 2007 between Old Lorus and the Company                                          
|2.24+             |  | Share Purchase Warrant related to the June 2012 Private Placement                                                        
|2.25^             |  | Form of Promissory note and Warrant issued June 19, 2013                                                                 
|2.26^             |  | Form of Convertible Promissory note issued September 26, 2013                                                            
|2.27^             |  | Underwriting Agreement dated November 22, 2013 in connection with the December 2013 public offering                      
|2.28^             |  | Underwriting Agreement dated March 27, 2014 in connection with the April 2014 public offering                            
|4.1#              |  | Security Based Compensation Plans as amended March 27, 2014                                                              
|4.2+++            |  | Form of Officer and Director Indemnity Agreement                                                                         
|4.3++             |  | Amalgamation Agreement dated August 23, 1991, among the Company, Mint Gold Resources Ltd., Harry J. Hodge and Wayne Beach
|4.4##^^           |  | Non-Exclusive License Agreement dated May 1, 2012 between the Company and Genentech, Inc.                                
|4.5+              |  | Indemnification Agreement dated July 10, 2007 between Old Lorus and the Company                                          
|4.8**             |  | Lease of Premises between the Company and 565991 Ontario Limited, dated July 27, 2001.                                   
|4.8.1^            |  | 2005 Amendment to July 27, 2001 Lease of Premises between the Company and 565991 Ontario Limited                         
|4.8.2^            |  | 2008 Amendment to July 27, 2001 Lease of Premises between the Company and 565991 Ontario Limited                         
|4.8.3^            |  | 2011 Amendment to July 27, 2001 Lease of Premises between the Company and 565991 Ontario Limited                         
|4.8.4^            |  | 2013 Amendment to July 27, 2001 Lease of Premises between the Company and 565991 Ontario Limited                         
|4.9^              |  | Executive Employment Agreement between the Company and
Dr. William G. Rice, dated October 25, 2013                       
|4.9a              |  | Amendment to the Employment agreement between the Company and Dr.
        William G. Rice dated August 19, 2014.         
|4.9.1^            |  | Executive Employment Agreement between the Company and Gregory K. Chow, dated November 29, 2013                          
|4.9.2^            |  | Executive Employment Agreement between the Company and Avanish Vellanki, dated November 29, 2013                         
|8.1#              |  | List of subsidiaries                                                                                                     
|11.1
        11.2 |  | Code of Business Conduct and Ethics.
        Audit Committee Charter                                                     
|12.1              |  | Certification of Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act                               
|12.2              |  | Certification of Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act                               
|13.1              |  | Certification of Chief Executive Officer pursuant to Section 906 of the Sarbanes-Oxley Act                               
|13.2              |  | Certification of Chief Financial Officer pursuant to Section 906 of the Sarbanes-Oxley Act                               
|15.1              |  | Management Discussion and Analysis for the seven months ended December 31, 2014                                          



|*  |  | Incorporated by reference to File 0-32001, Form 6-K, filed with the SEC on November 19, 2007.                        
|-- |  | ---------------------------------------------------------------------------------------------------------------------
|   |  |                                                                                                                      
|** |  | Incorporated by reference to File 000-19763, Form 20-F, filed with the SEC on December 16, 2002.                     
|   |  |                                                                                                                      
|+  |  | Incorporated by reference to File 1-32001, Form 6-K, filed with the SEC on September 4, 2007.                        
|   |  |                                                                                                                      
|++ |  | Incorporated by reference to File 0-19763, Registration Statement on Form 20-FR, filed with the SEC on March 4, 1992.



65







|+++ |  | Incorporated by reference to File 1-32001, Form 20-F, Annual Report, filed with the SEC on November 29, 2007.                     
|--- |  | ----------------------------------------------------------------------------------------------------------------------------------
|    |  |                                                                                                                                   
|^   |  | Incorporated by reference to File 1-32001, Form 20-F, Annual Report, filed with the SEC on May 16, 2014.                          
|    |  |                                                                                                                                   
|^^  |  | Confidential treatment has been obtained for portions of this document, which have been omitted and filed separately with the SEC.
|    |  |                                                                                                                                   
|^^^ |  | Incorporated by reference to File 1-32001, Form 6-K, filed with the SEC on September 2, 2014.                                     
|    |  |                                                                                                                                   
|#   |  | Incorporated by reference to File 1-32001, Form 20-F, Annual Report, filed with the SEC on July 30, 2014                          
|    |  |                                                                                                                                   
|##  |  | Incorporated by reference to File 1-32001, Form 20-F/A, Annual Report, filed with the SEC on January 11, 2013.                    



66













Consolidated Financial Statements of



aptose biosciences INC.



Seven month period ending December 31, 2014,

Years ended May 31, 2014 and 2013



















INDEPENDENT
auditors’ REPORT OF REGISTERED PUBLIC ACCOUNTING FIRM



To the Shareholders and Board of Directors of Aptose Biosciences
Inc.



We have audited the accompanying consolidated
financial statements of Aptose Biosciences Inc., which comprise the consolidated statements of financial position as of December
31, 2014 and May 31, 2014, the consolidated statements of loss and comprehensive loss, changes in shareholders’ equity
and cash flows for the seven-month period ended December 31, 2014 and for each of the years in the two-year period ended May 31,
2014, and notes, comprising a summary of significant accounting policies and other explanatory information.



Management’s Responsibility for the
Consolidated Financial Statements



Management is responsible for the preparation
and fair presentation of these consolidated financial statements in accordance with International Financial Reporting Standards
as issued by the International Accounting Standards Board, and for such internal control as management determines is necessary
to enable the preparation of consolidated financial statements that are free from material misstatement, whether due to fraud or
error.



Auditors’ Responsibility



Our responsibility is to express an opinion
on these consolidated financial statements based on our audits. We conducted our audits in accordance with Canadian generally accepted
auditing standards and the standards of the Public Company Accounting Oversight Board (United States). Those standards require
that we comply with ethical requirements and plan and perform the audit to obtain reasonable assurance about whether the consolidated
financial statements are free from material misstatement.



An audit involves performing procedures to obtain
audit evidence about the amounts and disclosures in the consolidated financial statements. The procedures selected depend on our
judgment, including the assessment of the risks of material misstatement of the consolidatedfinancial statements, whether
due to fraud or error. In making those risk assessments, we consider internal control relevant to the entity’s preparation
and fair presentation of the consolidated financial statements in order to design audit procedures that are appropriate in the
circumstances, but not for the purpose of expressing an opinion on the effectiveness of the entity’s internal control.An audit also includes evaluating the appropriateness of accounting policies used and the reasonableness of accounting
estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements.



We believe that the audit evidence we have obtained
in our audits is sufficient and appropriate to provide a basis for our audit opinion.



Opinion



In our opinion, the consolidated financial statements
referred to above present fairly, in all material respects, the consolidated financial position of Aptose Biosciences Inc. as of
December 31, 2014 and May 31, 2014, and its consolidated financial performance and its consolidated cash flows for the seven-month
period ended December 31, 2014 and for each of the years in the two-year period ended May 31, 2014 in accordance with International
Financial Reporting Standards as issued by the International Accounting Standards Board.











Chartered Professional Accountants, Licensed Public Accountants



March 3, 2015



Toronto, Canada











Aptose biosciences Inc.

Consolidated Statements of Financial Position

(Expressed in thousands of Canadian dollars)










|                                                        |  | December 31, |          |   | May 31, |  
|------------------------------------------------------- |  | ------------ | -------- | - | ------- | -
|                                                        |  | 2014         |          |   | 2014    |  
|                                                        |  |              |          |   |         |  
|Assets                                                  |  |              |          |   |         |  
|                                                        |  |              |          |   |         |  
|Current assets:                                         |  |              |          |   |         |  
|Cash and cash equivalents (note 4(a))                   |  | $            | 14,365   |   |         | $
|Investments (note 4(b))                                 |  |              | 16,180   |   |         |  
|Prepaid expenses and other assets                       |  |              | 855      |   |         |  
|Total current assets                                    |  |              | 31,400   |   |         |  
|                                                        |  |              |          |   |         |  
|Non-current assets:                                     |  |              |          |   |         |  
|Equipment and intangibles (note 5)                      |  |              | 200      |   |         |  
|Total non-current assets                                |  |              | 200      |   |         |  
|                                                        |  |              |          |   |         |  
|Total assets                                            |  | $            | 31,600   |   |         | $
|                                                        |  |              |          |   |         |  
|Liabilities and Shareholders' Equity                    |  |              |          |   |         |  
|                                                        |  |              |          |   |         |  
|Current liabilities:                                    |  |              |          |   |         |  
|Accounts payable                                        |  | $            | 256      |   |         | $
|Accrued liabilities (note 14)                           |  |              | 1,662    |   |         |  
|Convertible promissory notes (note 7)                   |  |              | 410      |   |         |  
|Total current liabilities                               |  |              | 2,328    |   |         |  
|                                                        |  |              |          |   |         |  
|Long term liabilities:                                  |  |              |          |   |         |  
|Convertible promissory notes (note 7)                   |  |              | -        |   |         |  
|Total long term liabilities                             |  |              | -        |   |         |  
|                                                        |  |              |          |   |         |  
|Shareholders' equity:                                   |  |              |          |   |         |  
|Share capital (note 9):                                 |  |              |          |   |         |  
|Common shares                                           |  |              | 221,259  |   |         |  
|Equity portion of convertible promissory notes (note 7) |  |              | 64       |   |         |  
|Stock options (notes 9(e) and 10)                       |  |              | 4,078    |   |         |  
|Contributed surplus (note 9(d))                         |  |              | 21,653   |   |         |  
|Warrants (note 9(c))                                    |  |              | 501      |   |         |  
|Deficit                                                 |  |              | (218,283 | ) |         |  
|Total shareholders' equity                              |  |              | 29,272   |   |         |  
|                                                        |  |              |          |   |         |  
|Total liabilities and shareholders' equity              |  | $            | 31,600   |   |         | $



See accompanying notes to consolidated
financial statements.



Commitments, contingencies and guarantees
(Note 14)

Subsequent events (Note 16)



On behalf of the Board:





|“Warren Whitehead” |  | Director
|------------------ |  | --------
|                   |  |         
|“Bradley Thompson” |  | Director





1







APTOSE Biosciences Inc.

Consolidated Statements of Loss and Comprehensive
Loss

(Expressed in thousands of Canadian dollars,
except for per common share data)



7 month period ended December 31, 2014
and 12 month periods ended May 31, 2014 and 2013












|                                                                                                         |  | 7 months ended    |        |   | 12 months ended May 31, |  
|-------------------------------------------------------------------------------------------------------- |  | ----------------- | ------ | - | ----------------------- | -
|                                                                                                         |  | December 31, 2014 |        |   | 2014                    |  
|                                                                                                         |  |                   |        |   |                         |  
|Revenue                                                                                                  |  | $                 | –      |   |                         | $
|                                                                                                         |  |                   |        |   |                         |  
|Expenses:                                                                                                |  |                   |        |   |                         |  
|Research and development (notes 6 and 12)                                                                |  |                   | 2,404  |   |                         |  
|General and administrative (note 12)                                                                     |  |                   | 5,588  |   |                         |  
|Operating expenses                                                                                       |  |                   | 7,992  |   |                         |  
|                                                                                                         |  |                   |        |   |                         |  
|Finance expense (note 11)                                                                                |  |                   | 58     |   |                         |  
|Finance income                                                                                           |  |                   | (279   | ) |                         |  
|Net finance (income) expense                                                                             |  |                   | (221   | ) |                         |  
|                                                                                                         |  |                   |        |   |                         |  
|Net loss and total comprehensive loss for period                                                         |  | $                 | (7,771 | ) |                         | $
|                                                                                                         |  |                   |        |   |                         |  
|Basic and diluted loss per common share                                                                  |  | $                 | (0.67  | ) |                         | $
|                                                                                                         |  |                   |        |   |                         |  
|Weighted average number of common shares outstanding used in the calculation of (in thousands) (note 9): |  |                   |        |   |                         |  
|Basic and diluted loss per common share                                                                  |  |                   | 11,605 |   |                         |  



See accompanying notes to consolidated
financial statements.

2







Aptose biosciences inc.

Consolidated Statements of Changes in
Shareholders' Equity

(Expressed in thousands of Canadian dollars)



7 months ended December 31, 2014 and years
ended May 31, 2014 and 2013














|                                                 |  | Share   |         |  | Stock   |   |       |          |  |   | Contributed |   |  | Equity portion |        |  |         |   |     |       | 
|------------------------------------------------ |  | ------- | ------- |  | ------- | - | ----- | -------- |  | - | ----------- | - |  | -------------- | ------ |  | ------- | - | --- | ----- | 
|                                                 |  | capital |         |  | options |   |       | Warrants |  |   | surplus     |   |  | of debt        |        |  | Deficit |   |     | Total | 
|                                                 |  |         |         |  |         |   |       |          |  |   |             |   |  |                |        |  |         |   |     |       | 
|Balance, May 31, 2014                            |  | $       | 212,938 |  |         | $ | 2,658 |          |  | $ | 1,857       |   |  | $              | 21,410 |  |         | $ | 88  |       | 
|Exercise of warrants (note 9(c))                 |  |         | 7,814   |  |         |   | -     |          |  |   | (1,166      | ) |  |                | -      |  |         |   | -   |       | 
|Exercise of stock options                        |  |         | 345     |  |         |   | (162  | )        |  |   | -           |   |  |                | -      |  |         |   | -   |       | 
|Conversion of promissory
    notes (note 7)      |  |         | 162     |  |         |   | -     |          |  |   | -           |   |  |                | 8      |  |         |   | (24 | )     | 
|Expiry of warrants                               |  |         | –       |  |         |   | –     |          |  |   | (190        | ) |  |                | 190    |  |         |   | –   |       | 
|Stock-based compensation
    (note 10)           |  |         | –       |  |         |   | 1,627 |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Expiry of stock options                          |  |         | –       |  |         |   | (45   | )        |  |   | –           |   |  |                | 45     |  |         |   | –   |       | 
|Net
    loss for the period                      |  |         | –       |  |         |   | –     |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Balance, December 31,
    2014                   |  | $       | 221,259 |  |         | $ | 4,078 |          |  | $ | 501         |   |  | $              | 21,653 |  |         | $ | 64  |       | 
|                                                 |  |         |         |  |         |   |       |          |  |   |             |   |  |                |        |  |         |   |     |       | 
|Balance, June 1, 2013                            |  | $       | 174,522 |  |         | $ | 1,018 |          |  | $ | 2,421       |   |  | $              | 21,217 |  |         | $ | –   |       | 
|Issuance of common shares (note 9(b)(ii))        |  |         | 6,927   |  |         |   | –     |          |  |   | 350         |   |  |                | –      |  |         |   | –   |       | 
|Issuance of common shares (note 9(b)(i))         |  |         | 25,584  |  |         |   | -     |          |  |   | -           |   |  |                | -      |  |         |   | -   |       | 
|Issuance of warrants (note
    9(b)(iii))        |  |         | –       |  |         |   | –     |          |  |   | 75          |   |  |                | –      |  |         |   | –   |       | 
|Issuance of convertible
    notes (note 7)       |  |         | –       |  |         |   | –     |          |  |   | –           |   |  |                | –      |  |         |   | 88  |       | 
|Exercise of warrants (note 9(c))                 |  |         | 5,422   |  |         |   | -     |          |  |   | (964        | ) |  |                | -      |  |         |   | –   |       | 
|Exercise of options and
    DSU’s (note 9(g))    |  |         | 483     |  |         |   | (18   | )        |  |   | -           |   |  |                | -      |  |         |   | -   |       | 
|Expiry of warrants                               |  |         | –       |  |         |   | –     |          |  |   | (25         | ) |  |                | 25     |  |         |   | –   |       | 
|Stock-based compensation
    (note 10)           |  |         | –       |  |         |   | 1,826 |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Cancellation and forfeiture
    of stock options |  |         | –       |  |         |   | (168  | )        |  |   | –           |   |  |                | 168    |  |         |   | –   |       | 
|Net
    loss for the year                        |  |         | –       |  |         |   | –     |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Balance, May 31, 2014                            |  | $       | 212,938 |  |         | $ | 2,658 |          |  | $ | 1,857       |   |  | $              | 21,410 |  |         | $ | 88  |       | 
|                                                 |  |         |         |  |         |   |       |          |  |   |             |   |  |                |        |  |         |   |     |       | 
|Balance, June 1, 2012                            |  | $       | 170,036 |  |         | $ | 535   |          |  | $ | 609         |   |  | $              | 21,186 |  |         | $ | –   |       | 
|Issuance of units (note
    9(b)(iv))            |  |         | 4,263   |  |         |   | –     |          |  |   | 1,855       |   |  |                | –      |  |         |   | –   |       | 
|Exercise of warrants (note 9(c))                 |  |         | 223     |  |         |   | –     |          |  |   | (43         | ) |  |                | –      |  |         |   | –   |       | 
|Stock-based compensation
    (note 10)           |  |         | –       |  |         |   | 514   |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Forfeiture of stock options                      |  |         | –       |  |         |   | (31   | )        |  |   | –           |   |  |                | 31     |  |         |   | –   |       | 
|Net
    loss for the year                        |  |         | –       |  |         |   | –     |          |  |   | –           |   |  |                | –      |  |         |   | –   |       | 
|Balance, May 31, 2013                            |  | $       | 174,522 |  |         | $ | 1,018 |          |  | $ | 2,421       |   |  | $              | 21,217 |  |         | $ | –   |       | 



See accompanying notes to consolidated
financial statements.



3







Aptose biosciences inc.

Consolidated Statements of Cash Flows

(Expressed in thousands of Canadian dollars)












|                                                                                      |  | 7 months ended    |        |   | 12 months ended May 31, |  
|------------------------------------------------------------------------------------- |  | ----------------- | ------ | - | ----------------------- | -
|                                                                                      |  | December 31, 2014 |        |   | 2014                    |  
|                                                                                      |  |                   |        |   |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Cash flows from operating activities:                                                 |  |                   |        |   |                         |  
|Net loss for the year                                                                 |  | $                 | (7,771 | ) |                         | $
|Items not involving cash:                                                             |  |                   |        |   |                         |  
|Stock-based compensation                                                              |  |                   | 1,627  |   |                         |  
|Depreciation and amortisation                                                         |  |                   | 22     |   |                         |  
|Finance income                                                                        |  |                   | (279   | ) |                         |  
|Finance expense                                                                       |  |                   | 58     |   |                         |  
|Other                                                                                 |  |                   | -      |   |                         |  
|Change in non-cash operating                                                          |  |                   |        |   |                         |  
|working capital (note 11)                                                             |  |                   | (374   | ) |                         |  
|Cash used in operating activities                                                     |  |                   | (6,717 | ) |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Cash flows from financing activities:                                                 |  |                   |        |   |                         |  
|Issuance of common shares and warrants, net of issuance costs (note 9(b)(i) and (ii)) |  |                   | -      |   |                         |  
|Exercise of warrants, options and DSU’s (note 9)                                      |  |                   | 6,831  |   |                         |  
|Issuance of convertible notes                                                         |  |                   | -      |   |                         |  
|Debt issuance costs                                                                   |  |                   | -      |   |                         |  
|Issuance of promissory notes and loans                                                |  |                   | -      |   |                         |  
|Repayment of promissory notes and loans                                               |  |                   | -      |   |                         |  
|Interest paid on notes and loans                                                      |  |                   | (30    | ) |                         |  
|Cash provided by financing activities                                                 |  |                   | 6,801  |   |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Cash flows from investing activities:                                                 |  |                   |        |   |                         |  
|Acquisition of investments                                                            |  |                   | (5,161 | ) |                         |  
|Purchase of equipment                                                                 |  |                   | (204   | ) |                         |  
|Interest received                                                                     |  |                   | 279    |   |                         |  
|Cash (used in) provided by investing activities                                       |  |                   | (5,086 | ) |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Increase (decrease) in cash and cash equivalents                                      |  |                   | (5,002 | ) |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Cash and cash equivalents, beginning of year                                          |  |                   | 19,367 |   |                         |  
|                                                                                      |  |                   |        |   |                         |  
|Cash and cash equivalents, end of year                                                |  | $                 | 14,365 |   |                         | $



Supplemental cash flow information (note
11)



See accompanying notes to consolidated
financial statements.



4







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 1. | Reporting entity:
| | -- | -----------------



Aptose Biosciences Inc. ("Aptose"
or the "Company") is a clinical-stage biotechnology company committed to discovering
and developing personalized therapies addressing unmet medical needs in oncology. Aptoseis a publicly listed company incorporated
under the laws of Canada. The Company's shares are listed on the Nasdaq Capital Markets and the Toronto Stock Exchange. The head
office, principal address and records of the Company are located at 2 Meridian Road, Toronto, Ontario, Canada, M9W 4Z7.



Aptose changed its name from
Lorus Therapeutics Inc. effective August 28, 2014.



Effective
July 17, 2014 the Company changed its fiscal year end from May 31 to December 31. As a result of that change the current reporting
fiscal period is for the seven months ended December 31, 2014 while the prior year comparative periods are for the twelve months
ended May 31, 2014 and 2013, and therefore are not directly comparable to the current seven month period.



| | 2. | Basis of presentation:
| | -- | ----------------------



| | (a) | Statement of compliance:
| | --- | ------------------------



These consolidated financial
statements of the Company and its subsidiaries are prepared in accordance with International Financial Reporting Standards ("IFRS")
as issued by the International Accounting Standards Board ("IASB"). The consolidated financial statements of the Company
were approved and authorized for issue by the Board of Directors on March 3, 2015.



| | (b) | Functional and presentation currency:
| | --- | -------------------------------------



The functional and presentation
currency of the Company is the Canadian dollar.



| | (c) | Significant accounting judgments, estimates and assumptions:
| | --- | ------------------------------------------------------------



The preparation of these
consolidated financial statements in accordance with IFRS requires management to make judgments, estimates and assumptions that
affect the application of accounting policies and reported amounts of assets and liabilities at the date of the consolidated financial
statements and reported amounts of revenue and expenses during the reporting period. Actual outcomes could differ from those estimates.
The consolidated financial statements include estimates, which, by their nature, are uncertain.



5







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 2. | Basis of presentation (continued):
| | -- | ----------------------------------



The impacts of such estimates
are pervasive throughout the consolidated financial statements and may require accounting adjustments based on future occurrences.



The estimates and underlying
assumptions are reviewed on a regular basis. Revisions to accounting estimates are recognized in the period in which the estimate
is revised and in any future periods affected.



The key assumptions concerning
the future and other key sources of estimation uncertainty as of the date of the statement of financial position that have a significant
risk of causing material adjustment to the carrying amounts of assets and liabilities within the next fiscal year include:



| | (i) | Valuation of contingent liabilities:
| | --- | ------------------------------------



The Company utilizes considerable
judgment in the measurement and recognition of provisions and the Company's exposure to contingent liabilities. Judgment is required
to assess and determine the likelihood that any potential or pending litigation or any and all potential claims against the Company
may be successful. The Company must estimate if an obligation is probable as well as quantify the possible economic cost of any
claim or contingent liability. Such judgments and assumptions are inherently uncertain. The
increase or decrease of one of these assumptions could materially increase or decrease the fair value of the liability and the
associated expense.



| | (ii) | Valuation of tax accounts:
| | ---- | --------------------------



Uncertainties exist with respect
to the interpretation of complex tax regulations and the amount and timing of future taxable income. Currently, the Company has
deductible temporary differences which would create a deferred tax asset. Deferred tax assets are recognized for all deductible
temporary differences to the extent that it is probable that future taxable profit will be available against which the deductible
temporary differences can be utilized. Management judgment is required to determine the amount of deferred tax assets that can
be recognized, based upon the likely timing and the level of future taxable profits together with future tax planning strategies.
To date, the Company has determined that none of its deferred tax assets should be recognized. The Company's deferred tax assets
are mainly comprised of its net operating losses from prior years and prior year research and development expenses. These tax pools
relate to entities that have a history of losses, have varying expiry dates, and may not be used to offset taxable income. As well,
there are no taxable temporary differences or any tax planning opportunities available that could partly support the recognition
of these losses as deferred tax assets. The generation of future taxable income could result in the recognition of some portion
or all of the remaining benefits, which could result in an improvement in the Company's results of operations through the recovery
of future income taxes.



6







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013












| | 2. | Basis of presentation (continued):
| | -- | ----------------------------------



| | (iii) | Valuation of share-based compensation and share purchase warrants:
| | ----- | ------------------------------------------------------------------



Management measures the
costs for share-based payments and share purchase warrants using market-based option valuation techniques. Assumptions are made
and judgment is used in applying valuation techniques. These assumptions and judgments include estimating the future volatility
of the share price, expected dividend yield, and employee turnover rates. Such judgments and assumptions are inherently uncertain.
The increase or decrease of one of these assumptions could materially increase or decrease the fair value of share-based payments
and share purchase warrants issued and the associated expense.



| | 3. | Significant accounting policies:
| | -- | --------------------------------



| | (a) | Basis of consolidation:
| | --- | -----------------------



The consolidated financial
statements include the accounts of the Company its 80% owned subsidiary, NuChem Pharmaceuticals Inc. (“NuChem”) and
its 100% owned subsidiary Aptose Biosciences Inc. USA (“Aptose USA”). NuChem has limited activity and the non-controlling
interest is not material to the financial statements of the Company. Aptose USA was incorporated in April 2014 and had limited
activity during the period ended December 31, 2014. A subsidiary is an entity over which the Company has control, being the power
to govern the financial and operating policies of the investee entity so as to obtain benefits from its activities. Accounting
policies of the subsidiaries are consistent with the Company's accounting policies. All intra-group transactions, balances, revenue
and expenses are eliminated on consolidation.



| | (b) | Foreign currency translation:
| | --- | -----------------------------



Foreign currency transactions
are translated into Canadian dollars at rates prevailing on the transaction dates. At the end of each reporting period, monetary
assets and liabilities denominated in foreign currencies are translated into Canadian dollars at the rates in effect at that date.
Gains or losses resulting from the translation to Canadian dollars are presented in the statement of loss and comprehensive loss
for the period within general and administrative expenses.



7







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



| | (c) | Derecognition of financial assets and liabilities:
| | --- | --------------------------------------------------



A financial asset is derecognized
when the right to receive cash flows from the asset have expired or when the Company has transferred its rights to receive cash
flows from the asset.



A financial liability is
derecognized when its contractual obligations are discharged, cancelled or expire.



| | (d) | Financial assets and liabilities:
| | --- | ---------------------------------



Financial assets within the
scope of IAS 39, Financial Instruments - Recognition and Measurement ("IAS 39"), are classified as either financial
assets at fair value through profit or loss, loans and receivables, held-to-maturity investments or available-for-sale financial
assets, as appropriate. When financial assets are recognized initially, they are measured at fair value, plus, in the case of
financial assets not at fair value through profit or loss, directly attributable transaction costs. The Company determines the
classification of its financial assets at initial recognition and, where allowed and appropriate, re-evaluates this designation
at each financial year end.



The Company's financial instruments
are comprised of the following:



|Financial assets                                                               |  | Classification        |  | Measurement   
|------------------------------------------------------------------------------ |  | --------------------- |  | --------------
|                                                                               |  |                       |  |               
|Cash and cash equivalents                                                      |  | Loans and receivables |  | Amortized cost
|Short-term investments                                                         |  | Loans and receivables |  | Amortized cost
|                                                                               |  |                       |  |               
|Financial liabilities                                                          |  | Classification        |  | Measurement   
|                                                                               |  |                       |  |               
|Accounts payable, accrued liabilities and convertible promissory notes payable |  | Other liabilities     |  | Amortized cost



The Company considers unrestricted
cash on hand and guaranteed investment certificates held by Canadian Schedule A banks with original maturities of three months
or less as cash and cash equivalents.



8







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



Fair value:



Fair value is the price that
would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the
measurement date. The fair value hierarchy establishes three levels to classify the inputs to valuation techniques used to measure
fair value.



| | · | Level 1 - inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities;
| | - | ------------------------------------------------------------------------------------------------------



| | · | Level 2 - inputs are quoted prices in markets that are not active, quoted prices for similar assets
or liabilities in active markets, inputs other than quoted prices that are observable for the asset or liability, or inputs that
are derived principally from or corroborated by observable market data or other means; and
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | · | Level 3 - inputs are unobservable (supported by little or no market activity). The fair value hierarchy
gives the highest priority to Level 1 inputs and the lowest priority to Level 3 inputs.
| | - | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The Company's financial assets
as at December 31, 2014 and May 31, 2014 which include cash and cash equivalents and short term investments are classified as a
Level 1 measurement.



| | (e) | Equipment:
| | --- | ----------



Equipment is measured at cost
less accumulated depreciation and accumulated impairment losses. Cost includes expenditures that are directly attributable to the
acquisition of the asset. The Company records depreciation at rates that charge operations with the cost of the assets over their
estimated useful lives on a straight-line basis as follows:



|Furniture              | 3 years      
|---------------------- | -------------
|Laboratory Equipment   | 5 years      
|Computer hardware      | 3 years      
|Leasehold improvements | Life of lease



The assets' residual value,
useful life and methods of depreciation are reviewed at each reporting period and adjusted prospectively if appropriate.



9







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



| | (f) | Intangible assets:
| | --- | ------------------



Intangible
assets are recorded at cost less accumulated amortization and accumulated impairment losses. The Company's intangible assets consist
of computer application software that is not an integral part of related hardware. Subsequent expenditures that increase application
software functionality are recognized in the carrying amount of intangible assets if they embody future economic benefit to the
Company. All other costs including the costs of day-to-day servicing of intangible assets are expensed as incurred. Amortization
is recognized in expense on a straight-line basis over the estimated useful lives of intangible assets from the date that they
are available for use, since this most closely reflects the expected pattern of consumption of the future economic benefits embodied
in the assets.



| | (g) | Research and development:
| | --- | -------------------------



Expenditures on research activities,
undertaken with the prospect of gaining new scientific or technical knowledge and understanding, are recognized in profit or loss
as incurred.



Development activities involve
a plan or design for the production of new or substantially improved products or processes. Development expenditures are capitalized
only if development costs can be measured reliably, the product or process is technically and commercially feasible, future economic
benefits are probable, and the Company intends to and has sufficient resources to complete development and to use or sell the asset.
The expenditures capitalized would include the cost of materials, direct labour, overhead costs that are directly attributable
to preparing the asset for its intended use, and borrowing costs on qualifying assets. Other development expenditures which do
not meet the criteria for capitalization are recognized in profit or loss as incurred.



Capitalized development costs
are recognized at cost less accumulated amortization and accumulated impairment losses.



The Company has not capitalized
any development costs to date.



| | (h) | Investment tax credits:
| | --- | -----------------------



Research and development investment
tax credits, which are earned as a result of incurring qualifying research and development expenditures, are recorded as a reduction
of the related expense or cost of the asset acquired when there is reasonable assurance that they will be realized.

10







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



The Company's claim for scientific
research and experimental development ("SR&ED") deductions and related investment tax credits for income tax purposes
are based on management's interpretation of the applicable legislation in the Income Tax Act (Canada). These amounts are subject
to review and acceptance by the Canada Revenue Agency or the Ontario Ministry of Finance prior to collection.



| | (i) | Employee benefits:
| | --- | ------------------



| | (i) | Short-term employee benefits:
| | --- | -----------------------------



Short-term employee benefit
obligations are measured on an undiscounted basis and are expensed as the related service is provided.



A liability is recognized for
the amount expected to be paid in short-term cash bonuses if the Company expects to pay these amounts as approved by the Board
of Directors as a result of past services provided by the employee and the obligation can be estimated reliably.



| | (ii) | Stock-based compensation:
| | ---- | -------------------------



The Company has a stock-based
compensation plan (the "Plan") available to officers, directors, employees and consultants with grants under the Plan
approved by the Company's Board of Directors. Under the Plan, the exercise price of each option equals the closing trading price
of the Company's stock on the day prior to the grant if the grant is made during the trading day or the closing trading price on
the day of grant if the grant is issued after markets have closed. Vesting is provided for at the discretion of the Board of Directors
and the expiration of options is to be no greater than 10 years from the date of grant.



Details regarding the determination
of the fair value of equity settled share-based transactions are set out in note 10.



The Company uses the fair value
based method of accounting for employee awards granted under the Plan. The Company calculates the fair value of each stock option
grant using the Black-Scholes option pricing model at the grant date. The stock-based compensation cost of the options is recognized
as stock-based compensation expense over the relevant vesting period of the stock options using an estimate of the number of options
that will eventually vest.



11







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



Stock options awarded to non-employees
are accounted for at the fair value of the goods received or the services rendered. The fair value is measured at the date the
Company obtains the goods or the date the counterparty renders the service. If the fair value of the goods or services cannot be
reliably measured, the fair value of the options granted will be used.



The Company has an alternate
compensation plan that provides directors and senior management with the option of receiving director's fees, salary, bonuses or
other remuneration ("Remuneration") in common shares rather than cash. Under the plan, the participant receives an allotment
from treasury of such number of shares as will be equivalent to the cash value of the Remuneration determined by dividing the Remuneration
by the weighted average closing common share price for the five trading days prior to payment date (the "5-day VWAP").
The issue price of the shares is the 5-day VWAP. There are currently no shares allotted for issuance under this plan.



The Company has a deferred
share unit (“DSU”) plan that provides directors the option of receiving payment for their services in the form of share
units rather than common shares or cash. Officers may also receive compensation under the plan as determined by the Board of Directors.
Share units entitle the director to elect to receive, on termination of his or her services with the Company, an equivalent number
of common shares, or the cash equivalent of the market value of the common shares at that future date. The plan gives the holder
of the DSU’s the option between settlement in cash or shares of Aptose and the Board of Directors of Aptose has the final
determination as to the method of settlement. It is currently the intention of the Board of Directors to comply with the wishes
of the holder in terms of settlement method.



For units issued under this
plan, the Company records an expense and a liability equal to the market value of the shares issued. The accumulated liability
is adjusted for market fluctuations on a quarterly basis.



There are currently no shares
allotted for issuance under this plan (May 31, 2014 – nil).



| | (j) | Loss per share:
| | --- | ---------------



Basic loss per share is computed
by dividing the net loss available to common shareholders by the weighted average number of shares outstanding during the year.
Diluted loss per share is computed similar to basic loss per share except that the weighted average shares outstanding is increased
to include additional shares for the assumed exercise of stock options and warrants, if dilutive. The number of additional shares
is calculated by assuming that outstanding stock options and warrants were exercised and that the proceeds from such exercises
were used to acquire common stock at the average market price during the year. The inclusion of the Company's stock options and
warrants in the computation of diluted loss per share has an anti-dilutive effect on the loss per share and, therefore, they have
been excluded from the calculation of diluted loss per share.



12







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



| | (k) | Income taxes:
| | --- | -------------



Deferred tax is recognized in
respect of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the
amounts used for taxation purposes.



Deferred tax assets and liabilities
are offset if there is a legally enforceable right to offset current tax liabilities and assets, and they relate to income taxes
levied by the same tax authority on the same taxable entity.



Deferred tax is measured at
the tax rates that are expected to be applied to temporary differences when they reverse, based on the laws that have been enacted
or substantively enacted by the reporting date. A deferred tax asset is recognized for unused tax losses, tax credits and deductible
temporary differences, to the extent that it is probable that future taxable profits will be available against which they can be
utilized.



| | (l) | Provisions:
| | --- | -----------



A provision is recognized if,
as a result of a past event, the Company has a present legal or constructive obligation that can be estimated reliably, and it
is probable that an outflow of economic benefits will be required to settle the obligation. Provisions are determined by discounting
the expected future cash flows at a pre-tax rate that reflects current market assessments of the time value of money and the risks
specific to the liability. The unwinding of the discount is recognized as a finance cost.



Employee entitlements to annual
leave are recognized as the employee earns them. A provision, stated at current cost, is made for the estimated liability at the
end of each reporting period.



The Company has recorded a
provision related to an indemnification as described in note 14.



13







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



| | (m) | Finance income and finance costs:
| | --- | ---------------------------------



Finance income comprises interest
income on funds invested. Interest income is recognized as it accrues in profit or loss using the effective interest method.



Finance costs comprise interest
expense on borrowings and are recognized in profit or loss using the effective interest method.



(n) Standards and Interpretations Adopted
in the Seven Months Ended December 31, 2014:



| | (i) | Amendment to IAS 32, Financial instruments: presentation ("IAS 32"):
| | --- | --------------------------------------------------------------------



The amendment to IAS 32 clarifies
the requirements relating to the offset of financial assets and financial liabilities. Specifically, the amendment clarifies that
an entity has a legally enforceable right to set-off if that right is not contingent on a future event and is enforceable both
in the normal course of business and in the event of default, insolvency or bankruptcy of the entity and all counterparties. The
adoption of the amendments to IAS 32 did not have any impact on the Company's consolidated financial statements.



| | (ii) | International Financial Reporting Interpretation Committee 21, Levies ("IFRIC 21"):
| | ---- | -----------------------------------------------------------------------------------



IFRIC 21 addresses the issue
of when to recognize a liability to pay a levy. The interpretation defines a levy, and specifies that the obligating event that
gives rise to the liability is the activity that triggers the payment of the levy, as identified by the legislation. The interpretation
provides guidance on how different levy arrangements should be accounted for, in particular, it clarifies that neither economic
compulsion nor the going concern basis of financial statement preparation implies that an entity has a present obligation to pay
a levy that will be triggered by operating in a future period. IFRIC 21 requires retrospective application. The adoption of IFRIC
21 did not have a material impact on the Company’s consolidated financial statements as the Company has not incurred levies.



14







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 3. | Significant accounting policies (continued):
| | -- | --------------------------------------------



(o) Recent
accounting pronouncements:



| | (i) | IFRS 9, Financial Instruments ("IFRS 9"):
| | --- | -----------------------------------------



IFRS 9 (2014) introduces new
requirements for the classification and measurement of financial assets. Under IFRS 9 (2014), financial assets are classified and
measured based on the business model in which they are held and the characteristics of their contractual cash flows. The standard
introduces additional changes relating to financial liabilities and also amends the impairment model by introducing a new ‘expected
credit loss’ model for calculating impairment. IFRS 9 (2014) also includes a new general hedge accounting standard which
aligns hedge accounting more closely with risk management. The Company intends to adopt IFRS 9 (2014) in its consolidated financial
statements for the annual period beginning on January 1, 2018. The extent of the impact of adoption of the standard has not yet
been determined.



| | (ii) | Amendments to IAS 1
| | ---- | -------------------



On December 18, 2014 the IASB
issued amendments to IAS 1 Presentation of Financial Statements as part of its major initiative to improve presentation and disclosure
in financial reports. The amendments are effective for annual periods beginning on or after 1 January 2016. Early adoption is permitted.
The Company intends to adopt these amendments in its consolidated financial statements for the annual period beginning on January
1, 2016. The extent of the impact of adoption of the amendments has not yet been determined.



| | 4. | Capital disclosures:
| | -- | --------------------



The Company's objectives when
managing capital are to:



| | · | Maintain a flexible capital structure which optimizes the cost of capital at acceptable risk; and
| | - | -------------------------------------------------------------------------------------------------



| | · | Ensure sufficient cash resources to fund its research and development activity, to pursue partnership
and collaboration opportunities and to maintain ongoing operations.
| | - | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The capital structure of the
Company consists of equity comprised of share capital, share purchase warrants, stock options, contributed surplus and deficit.
The Company manages its capital structure and makes adjustments to it in light of economic conditions. The Company, upon approval
from its Board of Directors, will balance its overall capital structure through new share issuances, acquiring or disposing of
assets, adjusting the amount of cash balances or by undertaking other activities as deemed appropriate under the specific circumstances.



The Company is not subject to
externally imposed capital requirements, and the Company's overall strategy with respect to capital risk management remains unchanged
from the year ended May 31, 2014.



15







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 4. | Capital disclosures (continued):
| | -- | --------------------------------



| | (a) | Cash and cash equivalents:
| | --- | --------------------------



Cash and cash equivalents consists
of cash of $293 thousand (May 31, 2014 - $2.3 million) and funds deposited into high interest savings accounts totalling $14.072
million (May 31, 2014 - $17.1 million). The current interest rate earned on these deposits is between 1.2% and 1.25% (May 31, 2014
– 1.2-1.25%).



(b) Investments:



As at December 31, 2014 and
May 31, 2014, short term investments consist of guaranteed investment certificates with Canadian financial institutions having
high credit ratings. Short-term investments include twelve investments (May 31, 2014 – eleven investments) with maturity
dates from April 22, 2015 to June 19, 2016 (May 31, 2014 – April 22, 2015 to May 8, 2016), bearing an interest rate from
1.50% to 2.10% (May 31, 2014 – 1.56% to 1.85%) per annum. Included in the investments balance are $8.1 million in investments
that mature in fiscal 2016.



There were no short term investments
outstanding as of May 31, 2013.





| | 5. | Equipment
and intangible assets:
| | -- | --------------------------------



Equipment:





|                       |  |      |     |  | Accumulated  |   |     | Net book | 
|---------------------- |  | ---- | --- |  | ------------ | - | --- | -------- | 
|December 31, 2014      |  | Cost |     |  | depreciation |   |     | value    | 
|                       |  |      |     |  |              |   |     |          | 
|Equipment              |  | $    | 545 |  |              | $ | 481 |          | 
|Computer hardware      |  |      | 36  |  |              |   | 14  |          | 
|Office furniture       |  |      | 38  |  |              |   | 37  |          | 
|Leasehold improvements |  |      | 25  |  |              |   | 1   |          | 
|                       |  | $    | 644 |  |              | $ | 533 |          | 



During the seven months ended December
31, 2014 the Company disposed of $1.5 million in fully depreciated equipment, $437 thousand in fully depreciated computer hardware
and $147 in fully depreciated office furniture no longer in use.



|                  |  |      |       |  | Accumulated  |   |       | Net book | 
|----------------- |  | ---- | ----- |  | ------------ | - | ----- | -------- | 
|May 31, 2014      |  | Cost |       |  | depreciation |   |       | value    | 
|                  |  |      |       |  |              |   |       |          | 
|Equipment         |  | $    | 1,979 |  |              | $ | 1,976 |          | 
|Computer hardware |  |      | 448   |  |              |   | 433   |          | 
|Office furniture  |  |      | 184   |  |              |   | 184   |          | 
|                  |  | $    | 2,611 |  |              | $ | 2,593 |          | 



16







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 5. | Equipment and intangible assets (continued):
| | -- | --------------------------------------------



Intangible
assets:



|                  |  |      |     |  | Accumulated  |   |    | Net book | 
|----------------- |  | ---- | --- |  | ------------ | - | -- | -------- | 
|December 31, 2014 |  | Cost |     |  | amortization |   |    | value    | 
|                  |  |      |     |  |              |   |    |          | 
|Computer software |  | $    | 105 |  |              | $ | 16 |          | 
|                  |  | $    | 105 |  |              | $ | 16 |          | 



During the seven months ended December
31, 2014 the Company disposed of $325 thousand in fully amortized computer software.



|                  |  |      |     |  | Accumulated  |   |     | Net book | 
|----------------- |  | ---- | --- |  | ------------ | - | --- | -------- | 
|May 31, 2014      |  | Cost |     |  | amortization |   |     | value    | 
|                  |  |      |     |  |              |   |     |          | 
|Computer software |  | $    | 325 |  |              | $ | 325 |          | 
|                  |  | $    | 325 |  |              | $ | 325 |          | 



| | 6. | Research and development programs:
| | -- | ----------------------------------



The Company has product candidates
in two classes of anti-cancer therapies:



| | (a) | Small molecule program:
| | --- | -----------------------



The Company
is developing small molecule therapies based on anti-proliferative and anti-metastatic properties that act at novel cancer specific
targets that target indications addressing large cancer markets.  The Company's proprietary group of small molecule compounds
includes lead drug APTO-253 in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and other hematologic malignancies. 
Additionally, the Company has a preclinical small molecule program targeting maternal embryonic leucine zipper kinase (MELK) for
the treatment of various cancers.



| | (b) | Large molecule program:
| | --- | -----------------------



The Company’s
large molecule program includes a molecule to target specific cell-surface receptors expressed in certain cancers expressing the
Interleukin-17E receptor (IL-17ER).  The molecule under development is IL-17E, which binds to IL-17ER to lead to targeted
cell killing.   IL-17E is also known to have activity in stimulating the anti-cancer properties of the immune system. 
IL-17E is a protein-based therapeutic in the pre-clinical stage of development.  The Company is not currently developing IL-17E
and is seeking to out-license the program.



17







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 6. | Research and development programs (continued):
| | -- | ----------------------------------------------



Program costs by product class are as
follows:



|                       |  | 7 months ended |       |  | 12 months ended |  
|---------------------- |  | -------------- | ----- |  | --------------- | -
|                       |  | December 31,   |       |  | May 31,         |  
|                       |  | 2014           |       |  | 2014            |  
|                       |  |                |       |  |                 |  
|Small molecule program |  | $              | 2,371 |  |                 | $
|Large molecule program |  |                | -     |  |                 |  
|                       |  | $              | 2,371 |  |                 | $



See note
12 for all components of research and development expenditures.



| | 7. | Convertible promissory notes and loans payable:
| | -- | -----------------------------------------------



| | a) | Convertible promissory notes
| | -- | ----------------------------



In September 2013, the Company completed
a private placement of convertible promissory notes for aggregate gross proceeds of $600 thousand. Each convertible promissory
note consists of a $1 thousand principal amount of unsecured promissory note convertible into common shares of the Company at a
price per share of $3.60. The promissory notes bear interest at a rate of 10% per annum, payable quarterly and are due September
26, 2015.



Certain related parties participated
in the transaction. A company related to Mr. Abramson, a former director of Aptose acquired $100 thousand of the promissory notes,
Mr. Sheldon Inwentash and his joint actors (“Mr. Inwentash”) was a related party of the Company by virtue of exercising
control or direction over more than 10% of the common shares, acquired $150 thousand of the promissory notes and Sprott Asset Management
which then held more than 10% of the common shares of Aptose acquired $112 thousand of the notes.



The promissory notes are a compound
financial instrument containing a liability component and an equity component represented by the conversion feature. The fair value
of the liability component upon issuance was estimated by discounting the future cash flows associated with the debt at a discounted
rate of approximately 19% which represents the estimated borrowing cost to the Company for similar promissory notes with no conversion
feature. The residual value of $88 thousand was allocated to the conversion feature.



Subsequent to initial recognition,
the promissory notes are being accounted for at amortized cost using the effective interest rate method. The Company incurred costs
associated with the financing of $17 thousand. These costs along with the adjustment for the conversion feature are being accreted
using the effective interest rate method over the 24 month life of the notes.



18







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 7. | Convertible promissory notes and loans payable (continued):
| | -- | -----------------------------------------------------------



During the seven months ended December
31, 2014, $162.5 thousand promissory notes with a carrying value of $146 thousand were converted into common shares of the Company.



|                                                           |  | December 31, |     |   | May 31, |  
|---------------------------------------------------------- |  | ------------ | --- | - | ------- | -
|                                                           |  | 2014         |     |   | 2014    |  
|                                                           |  |              |     |   |         |  
|Promissory notes                                           |  | $            | 438 |   |         | $
|Less: Unamortized adjustment for equity component of notes |  |              | (72 | ) |         |  
|Less: Issuance costs                                       |  |              | (17 | ) |         |  
|                                                           |  |              | 349 |   |         |  
|Accretion in carrying amount of notes                      |  |              | 61  |   |         |  
|Balance, end of period                                     |  | $            | 410 |   |         | $



b) Loans payable



In September 2013, the Company entered
into loan agreements for proceeds of $150 thousand. The loans were unsecured, bore interest at a rate of 10% per annum payable
quarterly and were due September 30, 2015. The Company repaid the loans and all accrued and unpaid interest thereon on April 25,
2014.





| | 8. | Financial
                                         instruments:
| | -- | ---------------------------------------------------------------



| | (a) | Financial instruments:
| | --- | ----------------------



The Company has classified
its financial instruments as follows:



|                                                                                                   |  | December 31, |        |  | May 31, |  
|-------------------------------------------------------------------------------------------------- |  | ------------ | ------ |  | ------- | -
|                                                                                                   |  | 2014         |        |  | 2014    |  
|                                                                                                   |  |              |        |  |         |  
|Financial assets:                                                                                  |  |              |        |  |         |  
|Cash and cash equivalents, consisting of high interest savings account, measured at amortized cost |  | $            | 14,365 |  |         | $
|Investments, consisting of guaranteed investment certificates, measured at amortized cost.         |  |              | 16,180 |  |         |  
|                                                                                                   |  |              |        |  |         |  
|Financial liabilities:                                                                             |  |              |        |  |         |  
|Accounts payable, measured at amortized cost                                                       |  |              | 256    |  |         |  
|Accrued liabilities, measured at amortized cost                                                    |  |              | 1,662  |  |         |  
|Convertible promissory notes, measured at amortized cost                                           |  |              | 410    |  |         |  



19







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 8. | Financial
                                         instruments (continued):
| | -- | ---------------------------------------------------------------------------





At December 31, 2014, there
are no significant differences between the carrying values of these amounts and their estimated market values due to their short-term
nature.



| | (b) | Financial risk management:
| | --- | --------------------------



The Company has exposure to
credit risk, liquidity risk and market risk. The Company's Board of Directors has the overall responsibility for the oversight
of these risks and reviews the Company's policies on an ongoing basis to ensure that these risks are appropriately managed.



| | (i) | Credit risk:
| | --- | ------------



Credit risk is the risk of financial
loss to the Company if a customer, partner or counterparty to a financial instrument fails to meet its contractual obligations,
and arises principally from the Company's cash and cash equivalents. The carrying amount of the financial assets represents the
maximum credit exposure.



The Company manages credit risk
associated with its cash and cash equivalents by maintaining minimum standards of R1-low or A-low investments and the Company invests
only in highly rated Canadian corporations which are capable of prompt liquidation.



| | (ii) | Liquidity risk:
| | ---- | ---------------



Liquidity risk is the risk that
the Company will not be able to meet its financial obligations as they come due. To the extent that the Company does not believe
it has sufficient liquidity to meet its current obligations, management and the Board consider securing additional funds through
equity, debt or partnering transactions. The Company manages its liquidity risk by continuously monitoring forecasts and actual
cash flows. All of the Company's financial liabilities are due within the current operating period.



| | (iii) | Market risk:
| | ----- | ------------



Market risk is the risk that
changes in market prices, such as interest rates, foreign exchange rates and equity prices, will affect the Company's income or
the value of its financial instruments.



20







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013












| | 8. | Financial
                                         instruments (continued):
| | -- | ---------------------------------------------------------------------------



The Company is subject to interest
rate risk on its cash and cash equivalents and short-term investments. The Company does not believe that the results of operations
or cash flows would be affected to any significant degree by a sudden change in market interest rates relative to the interest
rates on the investments, owing to the relative short-term nature of the investments. The Company does not have any material interest
bearing liabilities subject to interest rate fluctuations.



Financial instruments potentially
exposing the Company to foreign exchange risk consist principally of accounts payable and accrued liabilities. The Company holds
minimal amounts of U.S. dollar denominated cash, purchasing on an as-needed basis to cover U.S. dollar denominated payments. At
December 31, 2014, U.S. dollar denominated accounts payable and accrued liabilities amounted to $565 thousand (May 31, 2014 - $769
thousand). Assuming all other variables remain constant, a 10% depreciation or appreciation of the Canadian dollar against the
U.S. dollar would result in an increase or decrease in loss and comprehensive loss for the year of $57 thousand (May 31, 2014 -
$77 thousand). The Company does not have any forward exchange contracts to hedge this risk.





| | 9. | Share capital:
| | -- | --------------



Share
consolidation:

In accordance with the authority
granted by shareholders at the Company's annual and special meeting on August 19, 2014 to permit it to implement a consolidation
of the Company's outstanding common shares in a ratio of between 1-for-5 and 1-for-15, the Company's Board of Directors approved
a 1-for-12 share consolidation which became effective October 1, 2014. The share consolidation affects all of the Company's common
shares, stock options and warrants outstanding at the effective time. Fractional shares were not issued. Prior to consolidation
the Company had approximately 139 million shares outstanding. Following the share consolidation, the Company has approximately
11.6 million common shares outstanding. Similarly, prior to consolidation, the Company had approximately 17.1 million stock options
and 2.6 million warrants to purchase common shares outstanding. Following the share consolidation, the Company had approximately
1.4 million stock options and 218 thousand warrants to purchase common shares outstanding.



In these consolidated financial
statements, all references to number of shares, stock options and warrants in the current and past periods have been adjusted to
reflect the impact of the share consolidation. All amounts based on the number of shares, stock options or warrants, unless otherwise
specified, such as earnings (loss) per share and weighted average issuance price in the case of stock options have been adjusted
to reflect the impact of 1-for-12 share consolidation.



21







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 9. | Share capital (continued):
| | -- | --------------------------



| | (a) | Continuity of common shares and warrants:
| | --- | -----------------------------------------



|                                                   |  | Common shares  |        |  | Warrants |  
|-------------------------------------------------- |  | -------------- | ------ |  | -------- | -
|                                                   |  | Number         |        |  | Amount   |  
|                                                   |  | (In thousands) |        |  |          |  
|Balance, May 31, 2012                              |  |                | 1,769  |  |          | $
|Issuance of units (b)(iv)                          |  |                | 1,719  |  |          |  
|Issuance of finders warrants (b)(iv)               |  |                | –      |  |          |  
|Exercise of warrants (c)                           |  |                | 33     |  |          |  
|Balance, May 31, 2013                              |  |                | 3,521  |  |          | $
|Expiry of broker warrants                          |  |                | -      |  |          |  
|Issuance of warrants (b)(iii)                      |  |                | -      |  |          |  
|Warrant exercises                                  |  |                | 868    |  |          |  
|Finders warrants (b)(iv)                           |  |                | -      |  |          |  
|Option exercises                                   |  |                | 6      |  |          |  
|December equity offering and overallotment (b)(ii) |  |                | 1,220  |  |          |  
|April equity offering and overallotment (b)(i)     |  |                | 4,708  |  |          |  
|DSU exercise                                       |  |                | 65     |  |          |  
|Balance, May 31, 2014                              |  |                | 10,388 |  |          | $
|Warrant exercises                                  |  |                | 1,231  |  |          |  
|Warrant expiry                                     |  |                | -      |  |          |  
|Option exercises                                   |  |                | 36     |  |          |  
|Promissory note conversion                         |  |                | 45     |  |          |  
|Balance, December 31,
    2014                     |  |                | 11,700 |  |          | $



| | (b) | Equity issuances:
| | --- | -----------------



(i) April 2014 Public Equity Offering and Overallotment



In April 2014, the Company completed
a public offering of common shares. The Company issued 4,166,667 (pre-consolidation 50,000,000) common shares at a purchase price
of $6.00 ($0.50 pre-consolidation) per common share and an additional 541,667 (pre consolidation 6,500,000) common shares upon
the partial exercise of the over-allotment option for aggregate gross proceeds of $28.3 million. The total costs associated with
the transaction were approximately $2.7 million which includes a cash commission of $2.0 million based on 7% of the gross proceeds
received as part of the offering.



Mr. Inwentash, a former related
party of the Company, participated in this offering and acquired an aggregate of 108,333 (pre-consolidation 1,300,000) common shares.



(ii) December 2013 Public Equity Offering and Overallotment



In December 2013, Aptose completed
a public offering of common shares. Aptose issued 1,060,833 (pre-consolidation 12,730,000) common shares at a price of $6.60 (pre-consolidation
$0.55) per common share and an additional 159,125 (pre-consolidation 1,909,500) common shares upon the exercise of the overallotment
option for aggregate gross proceeds of $8.1 million.



22







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 9. | Share capital (continued):
| | -- | --------------------------



The total costs associated with
the transaction were approximately $1.1 million which include a cash commission of $483 thousand based on 6% of the gross proceeds
received as part of the offering, and the issuance of 73,198 (pre-consolidation 878,370) broker warrants with an estimated fair
value of $350 thousand. The fair value of these warrants was determined using the Black Scholes model with a 24 month time to
maturity, an assumed volatility of 130% and a risk free interest rate of 1.5%. Each broker warrant is exercisable into one common
share of the Company at a price of $6.60 (pre-consolidation $0.55) for a period of twenty four months following closing of the
offering.



Mr. Inwentash, a former related
party of the Company, participated in the Offering and acquired an aggregate of 151,667 (pre-consolidation 1,820,000) common shares.



(iii) June 2013 Private Placement

In June 2013 the Company completed
a private placement of units (“Units” in this section) at a price of $1 thousand per unit, for aggregate gross proceeds
of $918 thousand.



Each Unit consisted of (i) a
$1 thousand principal amount of unsecured promissory note and (ii) 83 (pre-consolidation 1,000) common share purchase warrants.
The promissory notes bore interest at a rate of 10% per annum, payable monthly and were due June 19, 2014. Each warrant entitled
the holder thereof to acquire one common share of the Company at a price per common share equal to $3.00 (pre-consolidation $0.25)
at any time until June 19, 2015.



Certain related parties participated
in the transaction. Directors and officers (including former officer Dr. Aiping Young, and former director Dr. Jim Wright and Dr.
Mark Vincent) acquired an aggregate of $68 thousand of the promissory notes. A company related to a Mr. Abramson, a former director
of the Company acquired $250 thousand of the promissory notes and Mr. Inwentash acquired $100 thousand of the promissory notes.



The Units contained a liability component
and an equity component represented by the warrants to purchase common shares. The fair value of the liability component of $843
thousand was estimated by discounting the future cash flows associated with the debt at a discounted rate of approximately 19%
which represents the estimated borrowing cost to the Company for similar promissory notes with no warrants. The residual value
of $75 thousand was allocated to the warrants. The Company incurred costs associated with the financing of $23 thousand. These
costs were amortized using the effective interest rate method over the 12 month life of the notes.



These notes and any interest accrued
thereon were repaid in full in April 2014.



23







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 9. | Share capital (continued):
| | -- | --------------------------



(iv) June
2012 Private Placement



On June 8, 2012 Aptose completed
a private placement (the “Private Placement”) of 1,718,750 (pre-consolidation 20,625,000) units at a subscription price
of $3.84 (pre-consolidation $0.32) per unit, each unit (“Unit”) consisting of one common share and one common share
purchase warrant for gross proceeds to Aptose of $6.6 million. Each warrant was exercisable for a period of 24 months from the
date of issuance at an exercise price of $5.40 (pre-consolidation $0.45) (the “Warrants”). Any unexercised warrants
expired on June 8, 2014.



Aptose paid a cash finder’s
fee of $396 thousand based on 6% of the gross proceeds of the Private Placement and issued 103,125 (pre-consolidation 1,237,500)
finder’s warrants with an exercise price of $3.84 (pre-consolidation $0.32) each. Each finder’s warrant was exercisable
into Units consisting of 103,125 (pre-consolidation 1,237,500) common shares and 103,125 (pre-consolidation 1,237,500) Warrants.
In May 2014, the finder’s Warrants were exercised and in June 2014 the underlying Warrants were also exercised.



The total costs associated
with the transaction were approximately $617 thousand which includes the $135 thousand which represented the estimated fair value
of the finders warrants issued as part of the Private Placement. Each such finder warrant was exercisable for one Unit at a price
of $3.84 (pre-consolidation $0.32) per Unit for a period of 24 months following the closing of the Offering. The Company allocated
the net proceeds of the Offering to the common shares and the common share purchase warrants based on their estimated relative
fair values. Based on relative fair values, $4.3 million of the net proceeds were allocated to the common shares and $1.7 million
to the common share purchase warrants.



| | (c) | Warrants:
| | --- | ---------



Warrants
exercised during the seven months ended December 31, 2014:



|(in thousands)                            |  | Number |       |  | Proceeds |  
|----------------------------------------- |  | ------ | ----- |  | -------- | -
|                                          |  |        |       |  |          |  
|August 2011 warrants (i)                  |  |        | 8     |  |          | $
|June 2012 private placement warrants (ii) |  |        | 1,223 |  |          |  
|Total                                     |  |        | 1,231 |  |          | $



In addition
to the cash proceeds received the original fair value related to these warrants of $1.2 million was transferred from warrants to
share capital. This resulted in a total amount of $7.8 million credited to share capital.



24







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










|9. |  | Share capital (continued):
|-- |  | --------------------------



Warrants
exercised during the year ended May 31, 2014:



|(in thousands)                             |  | Number |     |  | Proceeds |  
|------------------------------------------ |  | ------ | --- |  | -------- | -
|                                           |  |        |     |  |          |  
|August 2011 warrants (i)                   |  |        | 327 |  |          | $
|June 2012 private placement warrants (ii)  |  |        | 409 |  |          |  
|June 2012 finder warrants                  |  |        | 103 |  |          |  
|June 2013 private placement warrants (iii) |  |        | 29  |  |          |  
|Total                                      |  |        | 868 |  |          | $



In addition
to the cash proceeds received the original fair value related to these warrants of $964 thousand was transferred from warrants
to share capital. This resulted in a total amount of $5.4 million credited to share capital.



Warrants
exercised during the year ended May 31, 2013:



|(in thousands)           |  | Number |    |  | Proceeds |  
|------------------------ |  | ------ | -- |  | -------- | -
|                         |  |        |    |  |          |  
|August 2011 warrants (i) |  |        | 33 |  |          | $
|Total                    |  |        | 33 |  |          | $



In addition
to the cash proceeds received the original fair value related to these warrants of $43 thousand was transferred from warrants to
share capital. This resulted in a total amount of $223 thousand credited to share capital.



Summary of outstanding warrants:



|                                            |  | 7 months ended |     |  | 12 months ended | 
|------------------------------------------- |  | -------------- | --- |  | --------------- | 
|                                            |  | December 31,   |     |  | May 31,         | 
|(in thousands)                              |  | 2014           |     |  | 2014            | 
|                                            |  |                |     |  |                 | 
|August 2011 warrants (i)                    |  |                | 89  |  |                 | 
|June 2012 private placement warrants (ii)   |  |                | -   |  |                 | 
|June 2013 private placement warrants (iii)  |  |                | 47  |  |                 | 
|December 2013 broker warrants (iv)          |  |                | 73  |  |                 | 
|Number of warrants outstanding, end of year |  |                | 209 |  |                 | 



| | (i) | August 2011 warrants are exercisable into common shares of Aptose
at a price per share of $5.40 and expiring in August 2016.
| | --- | ----------------------------------------------------------------------------------------------------------------------------



| | (ii) | June 2012 warrants were exercisable into common shares of Aptose
at a price per share of $5.40 and expired on June 8, 2014. During the seven months ended December 31, 2014, 1.2 million warrants
were exercised and the balance expired unexercised.
| | ---- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (iii) | June 2013 private placement warrants are exercisable into common shares of Aptose at a price per
share of $3.00 and expiring in June 2015.
| | ----- | ------------------------------------------------------------------------------------------------------------------------------------------



25







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










|9. |  | Share capital (continued):
|-- |  | --------------------------



| | (iv) | December 2013 broker warrants
                                         are exercisable into common shares of Aptose at a price per share of $6.60 and expiring
                                         in December 2015.
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | Continuity of contributed surplus:
| | --- | ----------------------------------



Contributed surplus is comprised
of the cumulative grant date fair value of expired share purchase warrants and expired stock options as well as the cumulative
amount of previously expensed and unexercised equity settled share-based payment transactions.



|                               |  | 7 months ended |        |  | 12 months ended |  
|------------------------------ |  | -------------- | ------ |  | --------------- | -
|                               |  | December 31,   |        |  | May 31,         |  
|(in thousands)                 |  | 2014           |        |  | 2014            |  
|                               |  |                |        |  |                 |  
|Balance, beginning of period   |  | $              | 21,410 |  |                 | $
|Expiry of warrants (c)         |  |                | 190    |  |                 |  
|Expiry of stock options        |  |                | 45     |  |                 |  
|Conversion of promissory notes |  |                | 8      |  |                 |  
|Cancellation of stock options  |  |                | -      |  |                 |  
|Balance, end of period         |  | $              | 21,653 |  |                 | $



| | (e) | Continuity of stock options:
| | --- | ----------------------------



|                              |  | 7 months ended |       |   | 12 months ended |  
|----------------------------- |  | -------------- | ----- | - | --------------- | -
|                              |  | December 31,   |       |   | May 31,         |  
|(in thousands)                |  | 2014           |       |   | 2014            |  
|                              |  |                |       |   |                 |  
|Balance, beginning of period  |  | $              | 2,658 |   |                 | $
|Stock option expense          |  |                | 1,627 |   |                 |  
|Exercise of stock options     |  |                | (162  | ) |                 |  
|Expiry of stock options       |  |                | (45   | ) |                 |  
|Cancellation of stock options |  |                | -     |   |                 |  
|Balance, end of period        |  | $              | 4,078 |   |                 | $



| | (f) | Loss per share:
| | --- | ---------------



Loss per common share is calculated
using the weighted average number of common shares outstanding for the seven months ending December 31, 2014 of 11.605 million
and the years ending May 31, 2014 of 5.216 million and 3.521 million as of May 31, 2013, calculated as follows:



26







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 9. | Share capital (continued):
| | -- | --------------------------



|                                                        |  | 7 months ended |        |  | 12 months ended | 
|------------------------------------------------------- |  | -------------- | ------ |  | --------------- | 
|                                                        |  | December 31,   |        |  | May 31,         | 
|(in thousands)                                          |  | 2014           |        |  | 2014            | 
|                                                        |  |                |        |  |                 | 
|Issued common shares, beginning of period               |  |                | 10,388 |  |                 | 
|Effect of April 2014 public offering (note 9(b)(i))     |  |                | -      |  |                 | 
|Effect of December 2013 public offering (note 9(b)(ii)) |  |                | -      |  |                 | 
|Effect of Warrant exercises (note 9(c))                 |  |                | 1,200  |  |                 | 
|Effect of option and DSU exercises                      |  |                | 4      |  |                 | 
|Effect of promissory note conversion (note 7)           |  |                | 13     |  |                 | 
|Effect of private placement (note 9(b)(iv))             |  |                | -      |  |                 | 
|Issued weighted average common shares, end of period    |  |                | 11,605 |  |                 | 





The effect of any potential
exercise of the Company's stock options and warrants outstanding during the year has been excluded from the calculation of diluted
loss per common share as it would be anti-dilutive.



| | (g) | Deferred share unit plan:
| | --- | -------------------------



As at December 31, 2014 nil
deferred share units are outstanding (May 31, 2014 – nil, May 31, 2013 – 65,000). 65,000 common shares of the Company
were issued in April 2014 in satisfaction of the outstanding deferred share unit liability. The shares issued had a fair value
of $444 thousand.



| | 10. | Stock-based compensation:
| | --- | -------------------------



Stock option plan:



Under the Company's stock option
plan, options, rights and other entitlements may be granted to directors, officers, employees and consultants of the Company to
purchase up to a maximum of 15% of the total number of outstanding common shares, estimated at 1,754,000 options, rights and other
entitlements as at December 31, 2014. Options are granted at the fair market value of the common shares on the closing market date
immediately preceding the date of the grant. Options vest at various rates (immediate to three years) and have a term of 10 years.
Stock option transactions for the seven month period ended December 31, 2014 and the two years ended May 31, 2014 are summarized
as follows:



27







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 10. | Stock-based compensation (continued):
| | --- | -------------------------------------



|Option numbers are in (000’s)    |  |                                  |      
|-------------------------------- |  | -------------------------------- | -----
|                                 |  | 7 months ended December 31, 2014 |      
|                                 |  |                                  |      
|                                 |  |                                  |      
|                                 |  |                                  |      
|                                 |  | Options                          |      
|                                 |  |                                  |      
|Outstanding, beginning of period |  |                                  | 824  
|Granted                          |  |                                  | 604  
|Exercised                        |  |                                  | (36  
|Forfeited                        |  |                                  | (18  
|Outstanding, end of the period   |  |                                  | 1,374



|Option numbers are in (000’s)  | 
|------------------------------ | 
|                               | 
|                               | 
|                               | 
|                               | 
|                               | 
|                               | 
|Outstanding, beginning of year | 
|Granted                        | 
|Exercised                      | 
|Forfeited                      | 
|Cancelled                      | 
|Outstanding, end of year       | 



The following table summarizes
information about stock options outstanding at December 31, 2014:



|Option numbers are in (000’s) | 
|----------------------------- | 
|                              | 
|                              | 
|                              | 
|                              | 
|Range of                      | 
|exercise prices               | 
|                              | 
|$2.16 - $ 3.48                | 
|$3.48 - $ 5.70                | 
|$5.71 - $ 9.36                | 
|$9.37 - $118.80               | 
|                              | 



28







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 10. | Stock-based compensation (continued):
| | --- | -------------------------------------



The following assumptions
were used in the Black-Scholes option pricing model to determine the fair value of stock options granted during the period:



|                                                                           |  | 7 months ended |                  |   | 12 months ended |  
|-------------------------------------------------------------------------- |  | -------------- | ---------------- | - | --------------- | -
|                                                                           |  | December 31,   |                  |   | May 31,         |  
|                                                                           |  | 2014           |                  |   | 2014            |  
|                                                                           |  |                |                  |   |                 |  
|Exercise price                                                             |  | $              | 5.16-5.70        |   |                 | $
|Grant date share price                                                     |  |                | 5.16-5.70        |   |                 | $
|Risk-free interest rate                                                    |  |                | 1.5              | % |                 |  
|Expected dividend yield                                                    |  |                | -                |   |                 |  
|Expected volatility                                                        |  |                | 53-122           | % |                 |  
|Expected life of options                                                   |  |                | 3 months-5 years |   |                 |  
|Weighted average fair value of options granted or modified during the year |  | $              | 4.56             |   |                 | $



The Company uses historical
data to estimate the expected dividend yield and expected volatility of its common shares in determining the fair value of stock
options. The expected life of the options represents the estimated length of time the options are expected to remain outstanding.



Stock options granted by
the Company during the seven months ended December 31, 2014 vest 50% upon the first anniversary and 25% on each of the second and
third anniversaries.



Stock options granted by
the Company during the year ended May 31, 2014 consisted of 151,708 options which vested immediately, 70,833 options that vested
50% upon issuance and 25% on each of the next two anniversaries and 276,667 options which vest 50%, 25% and 25% on each of the
next three anniversaries, 70,833 options which vest in equal installments over 36 months and 3,125 options which vest in October
2014.



Stock options granted by the
Company during the year ended May 31, 2013 had various vesting schedules. Options granted to directors consisted of 13,333 options
that vested 50% upon issuance and 50% one year later. Options granted to the former CEO of 87,500 vest 50% after one year and 25%
on each of August 2, 2014 and August 2, 2015. Upon the departure of the former CEO in March 2014 the vesting of these options was
accelerated and they are fully vested as of May 31, 2014. Options granted to certain members of management totaled 27,083 and vested
50% upon certain performance criteria measured as of May 31, 2013 and 25% May 31, 2014 and 25% on May 31, 2015. Options granted
to employees totaled 20,417 and vest 50% after one year and 25% on each of August 2, 2015 and August 2, 2016.



Refer to note 12 for a breakdown
of stock option expense by function.



29







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 11. | Additional cash flow disclosures:
| | --- | ---------------------------------



Net change in non-cash operating
working capital is summarized as follows:



|                                  |  | 7 month ended |      |   | 12 months ended |  
|--------------------------------- |  | ------------- | ---- | - | --------------- | -
|                                  |  | December 31   |      |   | May 31          |  
|                                  |  | 2014          |      |   | 2014            |  
|Prepaid expenses and other assets |  | $             | (360 | ) |                 | $
|Accounts payable                  |  |               | (393 | ) |                 |  
|Accrued liabilities               |  |               | 379  |   |                 |  
|                                  |  | $             | (374 | ) |                 | $



During the seven months ended
December 31, 2014 the Company incurred interest on the convertible promissory notes described in note 7 of $30 thousand of which
$3 thousand was accrued and unpaid at December 31, 2014. The interest accrues at a rate of 10% per annum and is paid quarterly.
In addition the Company recorded accretion expense of $28 thousand as described in note 7.



During the year ended May
31, 2014 the Company paid $75 thousand in interest expense on the $918 thousand promissory notes as described in note 9(b)(iii)
and recorded accretion expense of $100 thousand related to the same promissory notes. These notes and all unpaid interest were
repaid in April 2014. The interest accrued at a rate of 10% per annum. In addition the Company incurred interest in the year ended
May 31, 2014 on the loan agreements and convertible promissory notes described in note 7 of $51 thousand of which $14 thousand
was accrued and unpaid at May 31, 2014. In addition the Company recorded $33 thousand of accretion expense as described in note
7. The interest accrues at a rate of 10% per annum and is paid quarterly. The loan agreements and all interest accrued thereon
were repaid in April 2014. In addition the Company paid interest of $3 thousand at a rate of 10% per annum to the withheld pay
of employees. All amounts withheld from employees had been repaid in December 2013.



During the year ended May
31, 2013, the Company incurred $6 thousand in interest expense on a $900 thousand promissory note due to a former Director. The
interest was paid at a rate of 10%.



30







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 12. | Other expenses:
| | --- | ---------------



Components of research and development
expenses:



|                                            |  | 7 month ended |       |  | 12 months ended |  
|------------------------------------------- |  | ------------- | ----- |  | --------------- | -
|                                            |  | December 31,  |       |  | May 31,         |  
|                                            |  | 2014          |       |  | 2014            |  
|                                            |  |               |       |  |                 |  
|Program costs (note 6)                      |  | $             | 2,371 |  |                 | $
|Severance cost for former President and COO |  |               | -     |  |                 |  
|Deferred share unit costs                   |  |               | -     |  |                 |  
|Stock-based compensation                    |  |               | 29    |  |                 |  
|Depreciation of equipment                   |  |               | 4     |  |                 |  
|                                            |  | $             | 2,404 |  |                 | $



Components of general and
administrative expenses:



|                                              |  | 7 month ended |       |  | 12 months ended |  
|--------------------------------------------- |  | ------------- | ----- |  | --------------- | -
|                                              |  | December 31,  |       |  | May 31,         |  
|                                              |  | 2014          |       |  | 2014            |  
|                                              |  |               |       |  |                 |  
|General and administrative excluding salaries |  | $             | 2,467 |  |                 | $
|Salaries                                      |  |               | 1,505 |  |                 |  
|Severance cost of former President and COO    |  |               | -     |  |                 |  
|Deferred share unit costs                     |  |               | -     |  |                 |  
|Stock-based compensation                      |  |               | 1,598 |  |                 |  
|Depreciation of equipment and amortisation    |  |               | 18    |  |                 |  
|                                              |  | $             | 5,588 |  |                 | $



| | 13. | Related party transactions:
| | --- | ---------------------------



See also notes 7 and 9 for related
party transactions.



These transactions were in the
normal course of business and have been measured at the exchange amount, which is the amount of consideration established and agreed
to by the related parties.



Compensation of key management
personnel:



31







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 13. | Related party transactions (continued):
| | --- | ---------------------------------------



Key management personnel are
those persons having authority and responsibility for planning, directing and controlling the Company's activities as a whole.
The Company has determined that key management personnel consists of the members of the Board of Directors along with the officers
of the Company. For the seven month period ended December 31, 2014 the officers were the Chairman, President and Chief Executive
Officer, the Chief Financial Officer as well as the Chief Business Officer. For the year ended May 31, 2014 the officers were
the Chairman, President and Chief Executive Officer, the Chief Financial Officer and the Chief Business Officer as well as the
Director of Finance, the former Vice President of Research and the former President and Chief Operating Officer. For the year
ended May 31, 2013 the officers were the former President and Chief Operating Officer, the Director of Finance and the former
Vice President of Research.



Officer compensation:



|                                          |  | 7 month ended |       |  | 12 months ended |  
|----------------------------------------- |  | ------------- | ----- |  | --------------- | -
|                                          |  | December 31,  |       |  | May 31,         |  
|                                          |  | 2014          |       |  | 2014            |  
|                                          |  |               |       |  |                 |  
|Salaries and short-term employee benefits |  | $             | 1,029 |  |                 | $
|Severance payment to the former COO       |  |               | -     |  |                 |  
|Deferred share units                      |  |               | -     |  |                 |  
|Stock-based compensation                  |  |               | 1,452 |  |                 |  
|                                          |  |               |       |  |                 |  
|                                          |  | $             | 2,481 |  |                 | $



Director compensation:



|                         |  | 7 month ended |     |  | 12 months ended |  
|------------------------ |  | ------------- | --- |  | --------------- | -
|                         |  | December 31,  |     |  | May 31,         |  
|                         |  | 2014          |     |  | 2014            |  
|                         |  |               |     |  |                 |  
|Directors' fees          |  | $             | 118 |  |                 | $
|Stock-based compensation |  |               | 117 |  |                 |  
|                         |  |               |     |  |                 |  
|                         |  | $             | 235 |  |                 | $



Included in accounts payable
and accrued liabilities is $29 thousand (May 31, 2014 - $268 thousand, May 31, 2013 - $126 thousand) due to directors and
officers of the Company relating to directors' fees, and reimbursements for employment expenses. These amounts are unsecured, non-interest
bearing and have no fixed terms of repayment.



32







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 14. | Commitments, contingencies and guarantees:
| | --- | ------------------------------------------



| | (a) | Operating lease commitments:
| | --- | ----------------------------



The Company has entered into
operating leases for premises and equipment under which it is obligated to make minimum annual payments as described below:



|                 |  | Less than 1 year |     |  | 1 - 3 years |   |     | 3 - 5 years |  |   | Total | 
|---------------- |  | ---------------- | --- |  | ----------- | - | --- | ----------- |  | - | ----- | 
|                 |  |                  |     |  |             |   |     |             |  |   |       | 
|Operating leases |  | $                | 150 |  |             | $ | 224 |             |  | $ | 248   | 



The Company's facility lease
in Toronto expires in March 2015 and the office facility lease in San Diego expires in January 2020.



In January 2015 the Company
entered into a new lease for lab facility space in San Diego and in February 2015 the Company entered into new lease facilities
in Toronto for both office and lab space. The annual cost for these new locations is expected to be approximately $300 thousand
per year.



The lease of the current Toronto
location contains certain restoration commitments which the Company will need to comply with upon the end of the March 31, 2015
lease. The Company has recorded a provision of $300 thousand as its current estimate of these costs.



| | (b) | Other contractual commitments:
| | --- | ------------------------------



The Company holds a non-exclusive
license from Genentech Inc. to certain patent rights to develop and sub-license a certain polypeptide. The Company does not expect
to make any milestone or royalty payments under this agreement in the fiscal years ended December 31, 2015 or 2016, and cannot
reasonably predict when such milestones and royalties will become payable, if at all.



| | (c) | Guarantees:
| | --- | -----------



The Company entered into various
contracts, whereby contractors perform certain services for the Company. The Company indemnifies the contractors against costs,
charges and expenses in respect of legal actions or proceedings against the contractors in their capacity of servicing the Company.
The maximum amounts payable from these guarantees cannot be reasonably estimated. Historically, the Company has not made significant
payments related to these guarantees.



33







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 14. | Commitments, contingencies and guarantees (continued):
| | --- | ------------------------------------------------------



The Company indemnifies its
directors and officers against any and all claims or losses reasonably incurred in the performance of their service to the Company
to the extent permitted by law. The Company has acquired and maintains liability insurance for its directors and officers. The
fair value of this indemnification is not determinable.



| | (d) | Indemnification on plan of arrangement:
| | --- | ---------------------------------------



On July 10, 2007, Aptose completed
a plan of arrangement and corporate reorganization whereby the assets and liabilities of Aptose were transferred from one corporate
entity into a new corporate entity which continued to operate as Aptose Therapeutics Inc. Under the arrangement, the Company agreed
to indemnify the old entity and its directors, officers and employees from and against all damages, losses, expenses, other third
party costs and legal expenses, to which any of them may be subject arising out of any matter occurring:



| | (i) | prior to, at or after the effective time of the arrangement ("Effective Time") and directly
or indirectly relating to any of the assets transferred to the Company pursuant to the arrangement (including losses for income,
sales, excise and other taxes arising in connection with the transfer of any such asset) or conduct of the business prior to the
Effective Time;
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (ii) | prior to, at or after the Effective Time as a result of any and all interests, rights, liabilities
and other matters relating to the assets transferred to the Company pursuant to the arrangement; and
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (iii) | prior to or at the Effective Time and directly or indirectly relating to, with certain exceptions,
any of the activities of the old entity or the arrangement.
| | ----- | --------------------------------------------------------------------------------------------------------------------------------------------------------------



The Company recorded a liability
of $50 thousand, which it believes to be a reasonable estimate of the fair value of the obligation for the indemnifications provided
as at December 31, 2014. There have been no claims on this indemnification to date.



| | 15. | Income taxes:
| | --- | -------------



Provision
for income taxes:



Major items causing the Company's
income tax rate to differ from the statutory rate of approximately 26.5% (May 31, 2014 – 26.5%, May 31, 2013 - 26.5%) are
as follows:



34







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 15. | Income taxes (continued):
| | --- | -------------------------



|                                                                    |  | 7 months ended |        |   | 12 months ended |  
|------------------------------------------------------------------- |  | -------------- | ------ | - | --------------- | -
|                                                                    |  | December 31,   |        |   | May 31,         |  
|                                                                    |  | 2014           |        |   | 2014            |  
|                                                                    |  |                |        |   |                 |  
|Loss before income taxes                                            |  | $(7,771)       |        |   | $(10,553)       |  
|Statutory Canadian corporate tax rate                               |  |                | 26.5   | % |                 |  
|                                                                    |  |                |        |   |                 |  
|Anticipated tax recovery                                            |  | $              | (2,059 | ) |                 | $
|Non-deductible permanent differences                                |  |                | 441    |   |                 |  
|Change in deferred tax benefits deemed not probable to be recovered |  |                | 1,643  |   |                 |  
|Undeducted financing costs                                          |  |                | -      |   |                 |  
|Other                                                               |  |                | (25    | ) |                 |  
|                                                                    |  |                |        |   |                 |  
|                                                                    |  | $              | -      |   |                 | $



The Company has undeducted
research and development expenditures, totaling $24.4 million that can be carried forward indefinitely.  The Company also
has non-refundable federal investment tax credits of approximately $5.0 million which are available to reduce future federal taxes
payable and begin to expire in 2026, as well as non-refundable Ontario research and development tax credits of approximately $442
thousand which are available to reduce future Ontario taxes payable and begin to expire in 2028.



In addition, the Company
has non-capital loss carryforwards of $30.8 million. To the extent that the non-capital loss carryforwards are not used, they expire
as follows:



|2015 |  | $ | 10     | 
|---- |  | - | ------ | 
|2026 |  |   | 11     | 
|2027 |  |   | 4,359  | 
|2028 |  |   | 3,744  | 
|2029 |  |   | 657    | 
|2030 |  |   | 2,907  | 
|2031 |  |   | 2,581  | 
|2032 |  |   | 3,479  | 
|2033 |  |   | 7,513  | 
|2034 |  |   | 5,499  | 
|     |  | $ | 30,760 | 



35







aptose biosciences inc.

Notes to Consolidated Financial Statements (continued)

(Tabular amounts in thousands of Canadian
dollars, except per share amounts)



Seven Months ended December 31, 2014, Years ended May 31, 2014 and
2013










| | 15. | Income taxes (continued):
| | --- | -------------------------



Deferred tax assets have not
been recognized in respect of the following items:



|                                            |  | December 31, |        |  | May 31, |  
|------------------------------------------- |  | ------------ | ------ |  | ------- | -
|                                            |  | 2014         |        |  | 2014    |  
|                                            |  |              |        |  |         |  
|Net operating losses carried forward        |  | $            | 8,148  |  |         | $
|Research and development expenditures       |  |              | 6,478  |  |         |  
|Equipment book over tax depreciation        |  |              | 459    |  |         |  
|Intangible asset                            |  |              | 3,097  |  |         |  
|Undeducted financing costs                  |  |              | 740    |  |         |  
|Ontario Research and Development Tax Credit |  |              | 442    |  |         |  
|Cumulative eligible capital                 |  |              | 346    |  |         |  
|Other                                       |  |              | -      |  |         |  
|Unrecognized deferred tax asset             |  | $            | 19,710 |  |         | $



| | 16. | Subsequent events:
| | --- | ------------------



On January 16, 2015, 108,000
stock options were granted to members of the Board of Directors and the Scientific Advisory Board of the Company at an exercise
price of $6.77. The options vest over a three year term and have a contractual life of ten years.



On January 20, 2015, $50 thousand
of the outstanding convertible promissory notes were converted into 13,888 common shares of the Company.



On February 12, 2015, 8,333
outstanding warrants were exercised into an equal number of common shares of the Company.



In addition, subsequent to the
seven months ended December 31, 2014 up until the date hereof, 45,625 outstanding stock options were exercised into an equal number
of common shares of the Company.



These transactions will be accounted
for in the first quarter of 2015.



36