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Title:   Author  item
                                            DALLOUL, RAMI - USDA, ARS, ANRI, APDLitem
                                            Lillehoj, Hyunitem
                                            DING, XICHENG - USDA, ARS, ANRI, APDLitem
                                            MIN, WONTI - USDA, ARS, ANRI, APDLitem
                                            HECKERT, ROBERT - USDA, ARS, BELTSVILLEitem
                                            KLINMAN, DENNIS - NETHESDA MD
  Submitted to: American Veterinary Medical Association Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/1/2004
                                    Publication  Date: 7/5/2004
                                    Citation: Dalloul, R., Lillehoj, H.S., Ding, X., Min, W., Heckert, R.A., Klinman, D.M. 2004. Cpg oligodeoxynucleutodes as vaccine adjuvants to eimeria in chickens. American Veterinary Medical Association, p. 21Interpretive Summary:
                                Technical Abstract: Current control measures against coccidiosis rely heavily upon prophylactic medication costing the poultry industry tremendously.  Existing coccidia vaccines consisting mostly of live oocysts have limited effectiveness and new control strategies are needed.  Short oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) represent potential candidate vaccine adjuvant.  We have demonstrated that CpG ODNs stimulate chicken macrophages to secrete nitric oxide and IL-6 in vitro, and exert a positive effect on weight loss and oocyst shedding associated with Eimeria infection when injected in vivo.  We will report new data of our CpG in ovo vaccination studies against Eimeria.


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