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Title:   Author  item
                                            Cantrell, Charlesitem
                                            GUSTAFSON, KIRK - NCI, FREDERICK, MDitem
                                            CECERE, MARGARET - NCI, FREDERICK, MDitem
                                            PANNELL, LEWIS - NCI, FREDERICK, MDitem
                                            BOYD, MICHAEL - NCI, FREDERICK, MD
  Submitted to: American Society of Pharmacognosy
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/26/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Marine sponges have yielded a wide variety of biologically active, structurally unique secondary metabolites.  Many of these compounds have exhibited potent cellular antiproliferative or cytotoxic activities.  Sponge extracts which produce distinctive patterns of differential cellular growth inhibition in the  National Cancer Institute's 60-cell antitumor screen have been selected for detailed chemical study within our laboratory.  The latest results from bioassay-guided fractionation of these sponge extracts and structural elucidation of the active constituents will be described.


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