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Title:   Author  item
                                            Harvey, Rogeritem
                                            Andrews, Kathleen

                                                         - *Kate*item
                                            Droleskey, Robert

                                                         - *Bob*item
                                            KANSAGRA, K - 6250-00-00item
                                            STOLL, B - 6250-00-00item
                                            Burrin, Douglas

                                                         - *Doug*item
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Edrington, Thomasitem
                                            Anderson, Robinitem
                                            Nisbet, David
  Submitted to: Proceedings of the International Symposium on Digestive Physiology in Pigs
                                    Publication Type: Book / Chapter
                                    Publication Acceptance Date: 3/25/2003
                                    Publication  Date: 5/14/2003
                                    Citation: Harvey, R.B., Andrews, K., Droleskey, R.E., Kansagra, K.V., Stoll, B., Burrin, D.G., Genovese, K.J., Edrington, T.S., Anderson, R.C., Nisbet, D.J. 2003. Clostridium difficile prevalence in the neonatal pig gut is increased by parenteral feeding versus enteral feeding. Proceedings of 9th International Symposium on Digestive Physiology in Pigs. II:111-113.Interpretive Summary: Preterm human infants and baby pigs can be infected by the bacteria Clostridium difficile.  In this study we used a pig model to try to determine what factors affect the ability of C. difficile to colonize neonates.  We found that intravenous feeding of neonates increases the risk of infection by C. difficile, whereas the presence of beneficial bacteria in the gut reduces the risk.  On the basis of this work, new methods of treating human infants and newborn pigs can be developed that may decrease the risk of infection by C. difficile.
                                Technical Abstract:  

In this study, we compared bacterial colonization and the translocation of gut bacteria in neonatal pigs that were subjected to total parenteral nutrition (TPN) versus enteral (ENT) feeding.   The ENT group had greater diversity of bacterial species, more segments of the GI tract colonized, and greater concentrations of gut bacteria than the TPN group.  The TPN group had increased (P < 0.1) Clostridium difficile toxin-A positive samples compared to the ENT group.  These data suggest that ENT treatment may enhance gut colonization in neonates whereas TPN treatment may place neonates at a higher risk for colonization by C. difficile.


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