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Title:   Author  item
                                            Anderson, Robinitem
                                            Jung, Yong Sooitem
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Harvey, Rogeritem
                                            Callaway, Todditem
                                            Byrd Ii, James

                                                         - *Allen*item
                                            Edrington, Thomasitem
                                            McReynolds, Jacksonitem
                                            Nisbet, David
  Submitted to: International Pig Veterinary Society (IPVS)
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 3/22/2004
                                    Publication  Date: 6/27/2004
                                    Citation: Anderson, R.C., Jung, Y., Genovese, K.J., Harvey, R.B., Callaway, T.R., Byrd II, J.A., Edrington, T.S., McReynolds, J.L., Nisbet, D.J. 2004. Effect of select nitrocompounds against Salmonella in porcine fecal suspensions. Proceedings of 18th International Pig Veterinary Society Congress. 2:679.Interpretive Summary:
                                Technical Abstract: Salmonella cause considerable economic losses to the swine industry due to disease and compromised food safety. Reports from North America and Europe have indicated that moderate to high prevalence of Salmonella can occur in apparently healthy finished hogs. Because these infected animals can be a major reservoir for contamination, a need exists to develop pre-slaughter strategies that will reduce the carriage of Salmonella into the abattoir. To test the effects of several experimental products against Salmonella Typhimurium, we incubated freshly collected porcine feces in vitro. We found that following 24 h incubation, Salmonella concentrations were not significantly reduced from an initial concentration of 6 log10 colony forming unit (CFU) to 5.9 log10 CFU in control incubations and were only slightly increased, but not significantly so (P>0.05), in incubations containing 5 mM added nitrate (6.2 log10 CFU). However, Salmonella concentrations were reduced (P<0.05) to 4.9 log10 CFU in incubations containing an added experimental chlorate product (ECP). Salmonella concentrations were reduced (P<0.05) even more, to 2.2 log10 CFU, in incubations containing both the EXP and 5 mM nitrate.  Salmonella concentrations were reduced (P<0.05) compared to concentrations in controls to 4.6 and to 2.3 log10 CFU in incubations containing 5 mM 2-nitroethanol or 2-nitropropanol, respectively, but were completely eliminated in incubations containing these nitrocompounds and ECP. These data suggest that the nitrocompounds may most effectively be used as a pre-conditioner to enhance the bactericidal activity of chlorate against enteropathogens in swine.


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