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Title:   Author  item
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            Dyer, Cherylitem
                                            Matteri, Robert
  Submitted to: Animal Science Progress Report
                                    Publication Type: Other
                                    Publication Acceptance Date: 10/12/1999
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Chilling is recognized as a major contributing factor associated with neonatal morbidity and mortality in the pig.  Thus, the objective of this study was to investigate the interaction between environmental temperature (ET) and endotoxin-induced hypothermia (chilling) in neonatal pigs.  At 24 h of age, 36 male piglets were placed in environmentally controlled  chambers maintained at 64.4 deg F (18 deg C) or 93.2 deg F (34 deg C; n=18 pigs/ET group).  Rectal temperatures (RT) were obtained prior to an intraperitoneal (i.p.) injection of saline (Cont; n=7/ET) or lipopolysaccharide (LPS; 150 ug/kg; n=11/ET) and every 15 min for 3 h. There was a TIME x ET x LPS interaction (P<0.0001) such that pigs at 64.4 deg F reacted more adversely over the 3 h period to LPS than those at 93.2 deg F.  Overall, RT for LPS pigs was lower (P=0.004) than that of Cont at 64.4 deg F.  At 93.2 deg F, there was no effect of LPS on RT (P>0.88).  Serum cortisol (CS) was elevated in all LPS pigs regardless of ET (P<0.04) however, the response was greater for LPS pigs at 64.4 deg F (196.8 ng/ml) vs 93.2 deg F (93.8 ng/ml).  These results provide evidence that ET can be utilized effectively to prevent LPS induced hypothermia in neonatal pigs.


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