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Title:   Author  item
                                            Kim, Jongitem
                                            SONG, JIAN - FORMER ARS EMPLOYEEitem
                                            Vallet, Jeffitem
                                            Rohrer, Garyitem
                                            Christenson, Ronald
  Submitted to: Biology of Reproduction Abstracts
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/4/2002
                                    Publication  Date: 12/20/2002
                                    Citation: Kim, J.G., Song, J.H., Vallet, J.L., Rohrer, G.A., Christenson, R.K. 2002. Endometrial expression and chromosomal location of the porcine bone morphogenic protein receptor-IB (BMPR-IB) gene [abstract]. Biology of Reproduction. 66(Supplement 1):278. (Abstract No. 445)Interpretive Summary:
                                Technical Abstract: Comparison of porcine and human genetic maps suggested that the bone morphogenic protein receptor IB (BMPR-IB) gene is located near a putative uterine capacity quantitative trait locus (QTL; 95% confidence interval 53-107 cM) on chromosome 8. The objectives of this study were to 1) clone the full coding region for BMPR-IB, 2) examine BMPR-IB gene expression by the endometrium during the estrous cycle and early pregnancy, and 3) map the BMPR-IB gene. A 3559 bp cDNA clone that included the full coding region (1509 bp) of BMPR-IB was obtained by iterative screening of an expressed sequence tag library. Expression of BMPR-IB mRNA by the endometrium of White composite gilts (n = 33) was determined by Northern blotting of total RNA from endometrium of D 10, 13, and 15 cyclic and D 10, 13, 15, 20, 30, and 40 pregnant gilts (n = 3 to 4 per D). Bands corresponding to BMPR-IB mRNA were quantified by densitometry and results were analyzed by ANOVA. In cyclic gilts, BMPR-IB mRNA expression was elevated (P < 0.01) on D 13 (204 +/ 30) and D 15 (246 +/ 25) compared to D 10 (109 +/ 25 arbitrary units). In pregnant gilts, BMPR-IB mRNA expression did not change between D 10 (138 +/ 25) and D 20 (125 +/ 25) and decreased (P = 0.011) on D 30 (78 +/ 25) and D 40 (60 +/ 30 arbitrary units). A C/T polymorphism located in intron 6 of the BMPR-IB gene was genotyped. The BMPR-IB gene was mapped to 108 cM on chromosome 8. The difference in BMPR-IB mRNA expression in the endometrium between cyclic and pregnant gilts suggests that BMPR-IB may play a role in endometrial changes occurring at the end of the estrous cycle (e.g., luteolysis) that are interrupted during pregnancy. The location of the BMPR-IB gene suggests that this gene may not be the gene responsible for the uterine capacity QTL.


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