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Title:   Author  item
                                            NAM, SEOK HYUN - AJOU UNIV. KOREAitem
                                            CHOI, SUN PHIL - AJOU UNIV. KOREAitem
                                            KANG, MI YOUNG - KYUNGPOOK UN. KOREAitem
                                            KOZUKUE, NOBUYUKI - YEUNGNAM UNV. KOREAitem
                                            Friedman, Mendel
  Submitted to: Journal of Agriculture and Food Chemistry
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 11/16/2004
                                    Publication  Date: 2/15/2005
                                    Citation: Nam, S., Choi, S., Kang, M., Kozukue, N., Friedman, M. 2005. Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical tests and in cell cultures. Journal of Agriculture and Food Chemistry.53:516-822.Interpretive Summary: As part of an effort designed to discover new, naturally-occurring antimicrobial and antiviral compounds, we participated in a collaborative study carried out in Korea which showed that experimental rice brans from pigmented rice varieties exhibited strong antioxidative, antimutagenic, and anticarcinogenic activities in chemical and cell assays. The results suggest that dark rice cultivars may provide a useful genetic resource for the development of improved health promoting rice varieties. Antioxidative rice brans and their biologically active components also merit testing for possible antibiotic activities against foodborne pathogens.
                                Technical Abstract: Ethanol-water (70:30, v/v) extracts from rice brans removed from seeds of two pigmented (Sanhaehyanghyulla and Suwon 415) blackish-purple and one nonpigmented (Chuchung) brown rice cultivars were evaluated for antioxidative, antitumor-promoting, and anticarcinogenic activities in chemical assays and in mammalian cells (human leukemia HL-60, marmoset B lymphoblastoid B95-8, and Chinese hamster V79 lung cells) using the following tests: reduction of potassium ferricyanide; scavenging of superoxide anions, hydroxyl radicals, and intracellular peroxides; inhibition of xanthine oxidase activity; chelation of ferrous ions; inhibition of 4-nitroquinoline N-oxide-induced mutagenesis; and inhibition of phorbol ester-induced tumor promotion  The extracts from the pigmented rice seeds had generally higher activities in all tests than did the extract from the nonpigmented variety.  The results suggest that brans from pigmented dark rice varieties may provide a source of new natural antioxidants and anticarcinogens and that such rice cultivars with high antioxidative potential also provide a genetic resource for the development of new, improved rice cultivars that may make it possible to enhance both the nutritional and medical value of rice-based diets.


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