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Title:   Author  item
                                            Kapczynski, Darrell
  Submitted to: Symposium on Avian Pneumovirus
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 2/28/2004
                                    Publication  Date: 6/23/2004
                                    Citation: Kapczynski, D.R. 2004. Development of a virosome vaccine for protection in turkeys against avian metapneumovirus subtype c. Symposium on Avian Pneumovirus. P.372.Interpretive Summary:
                                Technical Abstract: An avian metapneumovirus (aMPV) virosome vaccine was prepared and tested for protection of turkeys by aMPV challenge.  The vaccine was produced using a detergent-based (Triton X-100) extraction of aMPV subtype C  followed by detergent removal with SM2 Bio-Beads.  Western blot and virus-neutralization analysis confirmed that the aMPV virosomes contained both the fusion (F) and attachment (G) glycoproteins.  SPF turkeys were immunized either intranasally (IN) or intramuscularly (IM) with 2 doses of the aMPV virosome vaccine.  Vaccination decreased clinical signs of disease following virulent challenge and  IN vaccination was superior to IM vaccination in reducing clinical signs. Decreases in viral load in the respiratory tract were observed in turkeys receiving IN vaccination with aMPV virosomes compared to unvaccinated poults. Increased virus-neutralizing antibody levels against aMPV were observed in birds vaccinated with virosomes. These results demonstrate that immunization of turkeys with aMPV virosomes can be an effective strategy for control of disease.


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