EXHIBIT 12.1




CERTIFICATION PURSUANT TO RULE 13a-14(a) AS ADOPTED
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002




I, Aiping H. Young, certify that:


|1. |  | I have reviewed this annual report on Form 20-F of Lorus
Therapeutics Inc.;
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|2. |  | Based on my knowledge, this report does not contain any untrue
statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such
statements were made, not misleading with respect to the period covered by this report;
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|3. |  | Based on my knowledge, the financial statements, and other
financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of
the company as of, and for, the periods presented in this report;
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|4. |  | The companys other certifying officer and I are
responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the
company and have:
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|(a) |  | Designed such disclosure controls and procedures, or caused such
disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the company, including its
consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being
prepared;
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|(b) |  | Evaluated the effectiveness of the companys disclosure
controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end
of the period covered by this report based on such evaluation; and
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|(c) |  | Disclosed in this report any change in the companys
internal control over financial reporting that occurred during the period covered by the annual report that has materially affected, or is reasonably
likely to materially affect, the companys internal control over financial reporting; and
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|5. |  | The companys other certifying officer and I have
disclosed, based on our most recent evaluation of internal control over financial reporting, to the companys auditors and the audit committee of
the companys board of directors (or persons performing the equivalent functions):
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|(a) |  | All significant deficiencies and material weaknesses in the
design or operation of internal control over financial reporting which are reasonably likely to adversely affect the companys ability to record,
process, summarize and report financial information; and
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|(b) |  | Any fraud, whether or not material, that involves management or
other employees who have a significant role in the companys internal control over financial reporting.
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Date: November 21, 2006




/s/ Aiping H. Young Aiping H. Young President and
Chief Executive Officer


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