U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            GEHAD, A - RICHMOND, VAitem
                                            Lillehoj, Hyunitem
                                            HENDRICKS, G - UNIV PARK, PAitem
                                            MASHALY, M - UNIV PARK, PA
  Submitted to: Poultry Science
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 5/2/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Ability of poultry to mount an effective immune response depends upon successful interaction of neuroendocrine and immune system. In this report, ARS scientist in collaboration with scientists at the Pennsylvania Stata University and Virginia Commonwealth University, demonstrate ways how different stimuli induce host  immune response in chickens. They show that early production of chicken cytokines such as IL-1 is important for successful host immune response to pathogens. Understanding the factors which trigger effective poultry immune response will lead to a better management of poultry health by poultry industry and will reduce economic losses due to diseases.
                                Technical Abstract: The interaction between the components of the immune and endocrine systems can control the outcome of the immune response. The purpose of the present study was to investigate the role of different cytokines and hormones in the initiation of humoral immunity. Immature Cornell K-strain male chickens were injected i.v. with 8mg/kg BW of lipopolysaccharide (LPS) from  Escherichia coli, a T-independent antigen or with 40mg/kg BW bovine serum albumin (BSA), a T-dependent antigen. Control birds were injected with 0.9% saline. Blood and spleens were collected at 0, 1, 3, 6, and 24 h following the injections. The blood was centrifuged and the plasma was collected. Plasma samples were assayed for Interleukin-1 (IL-1) like activity using the thymocyte co-mitogensis assay following the precipitation of inhibitory factors with polyethylene glycol. Tumor necrosis factor-a (TNF-a ) like activity was measured as cytotoxic activity against the L929 mouse  fibroblast cell line. The plasma was also assayed for corticosterone and tri-iodothyronine (T3) by radioimmunoassays. Interleukin-2 (IL-2) activity was measured in the conditioned medium from splenic lymphocytes following their stimulation with the T-cell mitogen Concanavalin-A (Con-A) for 24 h.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov