U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            LINDSAY, DAVID - VA TECH, BLACKSBURG, VAitem
                                            Dubey, Jitender
  Submitted to: Veterinary Parasitology
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 5/30/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Equine protozoal myeloencephalitis (EPM) is a serious disease of horses caused by a single celled parasite, Sarcocystis neurona. There is no effective therapy.  Pyrantel tartrate is an anti- parasitic drug used by equine practitioners.  Scientists at the Beltsville Agricultural Research Center and Virginia Polytechnic  Institute and State University have found that pyrantel tartrate has no anti-S. neurona activity in gamma interferon knockout mice infected with sporocysts.  These results will be of interest to horse owners, veterinarians and parasitologists.
                                Technical Abstract: Equine protozoal myeloencephalitis (EPM) is the most important protozoal disease of horses in the United States.  Some horse owners and equine clinicians believe that horses which are on daily pyrantel tartrate at 2.64 mg/kg for helminth prophylaxis are less likely to develop EPM.  The present study examined the  efficacy of pyrantel tartrate in preventing clinical disease in gamma interferon gene knockout (BALB/c-Ifng[superscript tmlts endsuperscript]) mice.  No activity was seen against sporocyst- induced S. neurona infections in mice treated prophylacticly with 4 to 5 mg pyrantel tartrate per mouse per day in the drinking water.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov