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Title:   Author  item
                                            Anderson, Robinitem
                                            Callaway, Todditem
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Anderson, Timothyitem
                                            Edrington, Thomasitem
                                            Poole, Toniitem
                                            Bischoff, Kennethitem
                                            Nisbet, David
  Submitted to: International Conference on Production Diseases in Farm Animals
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 8/14/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Salmonella can cause disease and compromise food safety; consequently, strategies are sought to reduce their colonization of swine. Whereas oral gavage of sodium chlorate to pigs has been shown to kill Salmonella Typhimurium (ST) in the gut, more practical administration procedures are needed. Presently, we report that cecal and rectal concentrations of ST in  experimentally challenged weaned pigs allowed 36 h ad libitum access to water containing 15 mM sodium chlorate were reduced (P < 0.05) by 2.7 and 1.2 log units, respectively, when compared to concentrations measured in untreated pigs. For instance, cecal and rectal ST concentrations (mean +/- SD; n = 8) in untreated pigs were 3.3 +/- 2.2 and 1.3 +/- 1.4 log base 10 CFU/g, respectively and were 0.6 +/- 1.1 and 0.1 +/- 0.4 log base 10 CFU/g contents, respectively; in the treated pigs. Gut concentrations of ST were also reduced (P < 0.05), but less so, in pigs provided 24 h access to  water containing 15 mM sodium chlorate. Provision of drinking water containing 15 or 30 mM sodium chlorate to finished pigs for 24 h resulted in reductions of 2.1 and 1.4 log units in cecal and rectal ST concentrations, respectively when compared to concentrations in untreated pigs (3.8 +/- 0.7 and 1.9 +/- 1.6 log10 CFU, respectively; n = 6). No effect (P > 0.05) on water consumption (34 to 40 mL/kg body wt) was observed, thus demonstrating the practicality of administering sodium chlorate in drinking water.


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