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Title:   Author  item
                                            WAKAMATSU, N - UNIV OF GA - ATHENS, GAitem
                                            BROWN, C - UNIV OF GA - ATHENS, GAitem
                                            Kapczynski, Darrellitem
                                            Seal, Bruceitem
                                            King, Daniel
  Submitted to: Veterinary Pathology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/1/2004
                                    Publication  Date: 11/10/2004
                                    Citation: Wakamatsu, N., Brown, C., Kapczynski, D.R., Seal, B.S., King, D.J. 2004. Pathologic findings in chickens, turkeys, and pigeons experimentally infected with exotic newcastle disease virus from an outbreak in california during 2002-2003 [abstract]. Veterinary Pathology. 41(5):581.Interpretive Summary:
                                Technical Abstract: Exotic Newcastle disease virus (NDV) isolated from chickens during the 2002-2003 California outbreak was inoculated into 4-week-old SPF White Leghorn chickens, 3-week-old SPF Beltsville White turkeys, 6-week-old commercial Broad Breast White turkeys, and 10 to 20-week-old racing pigeons. Birds were monitored clinically and euthanized sequentially, with oral and cloacal swabs, blood, and tissues collected. Tissues were examined by histopathology and by immunohistochemistry and/or in situ hybridization to detect viral replication and distribution. Clinically, infected chickens and SPF turkeys showed severe depression and all died or were euthanized due to severe clinical signs by 5 days postinoculation. In these birds, histologic lesions were widespread and virus was detected in multiple organs. However, in commercial turkeys and in pigeons, less than 15% of birds showed overt clinical signs, histologic lesions were minimal, and viral distribution was limited. In this study susceptibility to highly virulent NDV did vary among chickens, SPF turkeys, commercial turkeys, and pigeons.


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