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Title:   Author  item
                                            ZHANG, QINGLIN - UNIVERSITY OF MISSISSIPPIitem
                                            Schrader, Kevinitem
                                            ELSOHLY, HALA - UNIVERSITY OF MISSISSIPPIitem
                                            TAKAMATSU, SATOSHI - UNIVERSITY OF MISSISSIPPI
  Submitted to: Journal of Antibiotics
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 7/8/2003
                                    Publication  Date: 8/11/2003
                                    Citation: ZHANG, Q., SCHRADER, K., ELSOHLY, H.N., TAKAMATSU, S. NEW CELL-CELL ADHESION INHIBITORS FROM STREPTOMYCES SP. UMA-044. JOURNAL OF ANTIBIOTICS. 2003. V. 56(8). P. 673-681.Interpretive Summary: Two new compounds were discovered from a type of bacteria isolated from catfish pond sediments that help prevent processes that cause inflammation in humans.  These new compounds may be useful as novel therapeutic drugs for inflammatory diseases such as rheumatoid arthritis.
                                Technical Abstract: Three compounds, NP25301, NP25302 and bohemamine, inhibitors of cell adhesion based on LFA-1/ICAM-1, were isolated from the cultured broth of the strain Streptomyces sp. UMA-044.  New compounds NP25301 and NP25302 were identified as 2-(3'-hydroxybenzamide) acrylic acid methylester and deoxybohemamine, respectively, based on streptoscopic analyses.  Compounds NP25301, NP25302 and bohemamine inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 29.5 ug/mL, 24.3 ug/mL, and 27.2 ug/mL, respectively.


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