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Title:   Author  item
                                            FERRO, PAMELA - TX A&M UNIVitem
                                            Swaggerty, Christina

                                                         - *Christi*item
                                            LOWRY, VIRGINIA - TX A&M UNIVitem
                                            KAISER, PETE - INST FOR ANIM HEALTH, UKitem
                                            ROTHWELL, LISA - INST FOR ANIM HEALTH, UKitem
                                            Kogut, Michael

                                                         - *Mike*
  Submitted to: World Veterinary Poultry Association
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/21/2003
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Previous studies have demonstrated invasion by Salmonella enteritidis (SE) results in an influx of heterophils to the site of infection.  Other studies have shown invasion by SE causes an eight- to tenfold increase in the production of the proinflammatory cytokine IL-6. The objective of the present study was to examine the in vitro effects of recombinant interleukin 6 (rIL-6) on the functional activity of day-old chicken heterophils.  Heterophils were isolated from day-old leghorn chicks and subsequently incubated with different concentrations of rIL-6 (Cos cell derived) or mock transfected Cos cell supernatant for 2 hours at 39 deg C.  Functional activity was assessed using four different assays measuring phagocytosis, oxidative burst, bactericidal killing, and degranulation.  Heterophils treated with rIL-6 showed no difference from heterophils that were either untreated or treated with mock transfected Cos cell supernatant.  These data would indicate rIL-6, alone, does not increase phagocytic, oxidative, or nonoxidative killing activities of day-old chicken heterophils.


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