exv4w5






Exhibit 4.5




          TWELFTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of June 16,
2011, among ALERE INC., a Delaware corporation (the “Issuer”), each of the Guarantors under the
Indenture referred to below (the “Guarantors”), and THE BANK OF NEW YORK MELLON TRUST COMPANY,
N.A., as Trustee under the Indenture referred to below (the “Trustee”).




WITNESSETH:




          WHEREAS the Issuer has heretofore executed and delivered to the Trustee an Indenture dated as
of August 11, 2009, as amended, supplemented and modified by a First Supplemental Indenture dated
as of August 11, 2009, a Second Supplemental Indenture dated as of September 22, 2009, a Fourth
Supplemental Indenture dated as of November 25, 2009, a Sixth Supplemental Indenture dated as of
February 1, 2010, an Eighth Supplemental Indenture dated as of March 1, 2010 and a Tenth
Supplemental Indenture dated as of March 19, 2010 (as so amended, supplemented and modified, and as
further amended, supplemented or modified to date, the “Indenture”), by and among the Issuer, the
Guarantors and the Trustee, providing for the issuance of 7.875% Senior Notes due 2016 (the
“Notes”);




          WHEREAS, pursuant to that certain Consent Solicitation Statement dated May 31, 2011, as
amended and supplemented to date (the “Consent Solicitation Statement”), the Issuer solicited the
consents of the holders of the Notes to the Record Date Amendments and Waivers (as defined in the
Consent Solicitation Statement) with respect to the Indenture;




          WHEREAS, the approval by written consent of the holders of at least a majority of the
aggregate principal amount of the Notes outstanding as of April 29, 2011 (the “Record Date”), which
is the record date fixed by the Issuer in accordance with Section 9.04 of the Indenture, of which
record date the Trustee has been duly notified in writing by the Issuer in accordance with Section
9.04, is sufficient to approve the aforesaid Record Date Amendments and Waivers in accordance with
the Indenture;




          WHEREAS, having received the approval of the holders of at least a majority of the aggregate
principal amount of the Notes outstanding as of the Record Date (the “Requisite Consent”) pursuant
to Section 9.02(a) of the Indenture with respect to the Record Date Amendments and Waivers, the
Issuer, the Guarantors and the Trustee desire to effect the Record Date Amendments and Waivers as
provided hereinafter;




          WHEREAS, all conditions precedent set forth in the Consent Solicitation Statement and the
Indenture to the execution and delivery of this of this Supplemental Indenture by the Issuer, the
Guarantors and the Trustee have been satisfied, and all things necessary have been done to make
this Twelfth Supplemental Indenture, when executed and delivered by the Issuers and the Guarantors,
the legal, valid and binding agreement of the Issuers and the Guarantors, in accordance with its
terms; and




          WHEREAS, the Issuer and the Guarantors have requested that the Trustee execute and deliver
this Twelfth Supplemental Indenture;




 









 








          NOW, THEREFORE in consideration of the foregoing and for other good and valuable
consideration, the receipt of which is hereby acknowledged, the parties to this Twelfth
Supplemental Indenture hereby agree as follows:




          SECTION 1. Definitions. For all purposes of this Supplemental Indenture, except as
otherwise herein expressly provided or unless the context otherwise requires: (i) the terms and
expressions used herein shall have the same meanings as corresponding terms and expressions used in
the Indenture; and (ii) the words “herein,” “hereof” and “hereby” and other words of similar import
used in this Supplemental Indenture refer to this Supplemental Indenture as a whole and not to any
particular section hereof.




          SECTION 2. Amendment of Section 9.04. The first sentence of the second paragraph of
Section 9.04 of the Indenture (Revocation and Effect of Consents) is hereby amended and restated in
its entirety as follows:





     “The Issuer may, but shall not be obligated to, fix a record date for the purpose of
determining the Holders entitled to consent to any amendment, supplement or waiver, which
record date shall be any date the Issuer shall select for such purpose in its sole
discretion.”



          SECTION 3. Record Date Waivers. In accordance with Section 9.02(a) of the Indenture,
the Record Date Waivers (as defined in the Consent Solicitation Statement), having received the
Requisite Consent, are hereby effective (subject to Section 4) in accordance with Article IX of the
Indenture and incorporated herein by reference.




          SECTION 4. Effectiveness of Amendments and Waivers. This Supplemental Indenture
shall be effective upon execution hereof by the Issuer, the Guarantors and the Trustee; provided,
however, that the aforesaid Record Date Amendments and Waivers shall not take effect until the
payment of the Consent Fee (as defined in the Consent Solicitation Statement) in accordance with
the Consent Solicitation Statement . If the Consent Solicitation (as defined in the Consent
Solicitation Statement) is terminated, withdrawn or otherwise not completed in accordance with the
Consent Solicitation, or the Consent Fee is not paid in accordance with the Consent Solicitation
Statement, this Supplemental Indenture shall automatically become null and void ab initio.




          SECTION 5. Ratification of Indenture; Supplemental Indenture Part of Indenture.
Except as expressly modified hereby, the Indenture is in all respects ratified and confirmed and
all the terms, conditions and provisions thereof shall remain in full force and effect. This
Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder of
Notes heretofore or hereafter authenticated and delivered shall be bound hereby.




          SECTION 6. Governing Law. This Supplemental Indenture shall be governed by, and
construed in accordance with, the laws of the State of New York, but without giving effect to
applicable principles of conflicts of laws to the extent that the application of the laws of
another jurisdiction would be required thereby.




          SECTION 7. Trustee Makes No Representation. The Trustee makes no representation as to
the validity or sufficiency of this Supplemental Indenture.




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          SECTION 8. Counterparts. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them together represent
the same agreement.




          SECTION 9. Effect of Headings. The Section headings herein are for convenience only
and shall not effect the construction thereof.




[Signature Page Follows]




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          IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written.




	 	 	 	 	 
	 	ISSUER:



ALERE INC.

 	 
	 	By:  	/s/ David A. Teitel
 	 
	 	 	Name:  	David A. Teitel 	 
	 	 	Title:  	Chief Financial Officer and Treasurer 	 
	 



Signature Page to Twelfth Supplemental Indenture — 7.875% Notes due 2016








 









 








	 	 	 	 	 
	 	GUARANTORS:



ALERE GENETICS, INC.

ALERE HEALTH IMPROVEMENT COMPANY

ALERE HEALTH, LLC

ALERE HEALTH SYSTEMS, INC.

ALERE HEALTHCARE OF ILLINOIS, INC.

ALERE HOME MONITORING, INC.

ALERE INTERNATIONAL HOLDING CORP.

ALERE MEDICAL, INC.

ALERE OF NEW YORK, INC.

ALERE NEWCO, INC.

ALERE NEWCO II, INC.

ALERE NORTH AMERICA, INC.

ALERE SAN DIEGO, INC.

ALERE SCARBOROUGH, INC.

ALERE US HOLDINGS, LLC

ALERE WELLOLOGY INC.

ALERE WOMEN’S AND CHILDREN’S HEALTH, LLC

AMEDITECH INC.

BINAX, INC.

 	 
	 	By:  	/s/ David A. Teitel
 	 
	 	 	Name: David A. Teitel 	 
	 	 	Title (respectively):
Vice President and
Treasurer; Vice President, Finance; Vice
President and Treasurer; Vice President and
Treasurer; Vice President, Finance; Vice
President, Finance; President; Vice
President and Treasurer; President; Vice
President, Finance; President; Vice
President, Finance; Vice President, Finance;
Vice President, Finance; President; Vice
President, Finance; Vice President, Finance;
General Manager; Vice President; Vice
President, Finance 
	 
	 



Signature Page to Twelfth Supplemental Indenture — 7.875% Notes due 2016








 









 








	 	 	 	 	 
	 	GUARANTORS (continued):



BIOSITE INCORPORATED

CHOLESTECH CORPORATION

FIRST CHECK DIAGNOSTICS CORP.

FIRST CHECK ECOM, INC.

ALERE WELLBEING, INC.

HEMOSENSE, INC.

INNOVACON, INC.

INSTANT TECHNOLOGIES, INC.

INVERNESS MEDICAL, LLC

IVC INDUSTRIES, INC.

QUALITY ASSURED SERVICES, INC.

REDWOOD TOXICOLOGY LABORATORY

RMD NETWORKS, INC.

RTL HOLDINGS, INC.

SELFCARE TECHNOLOGY, INC.

WAMPOLE LABORATORIES, LLC

ZYCARE, INC.

 	 
	 	By:  	/s/ David A. Teitel
 	 
	 	 	Name: David A. Teitel 	 
	 	 	Title (respectively):
Vice President, Finance;
Vice President, Finance; Vice President,
Finance; Vice President; Vice President,
Finance and Treasurer; Treasurer; Vice
President, Finance; Vice President, Finance;
Vice President, Finance; Vice President;
Vice President, Finance; Vice President,
Finance; Vice President, Finance and
Treasurer; Vice President, Finance; Vice
President, Finance; President; Vice
President; Chief Financial Officer and
Treasurer 
	 
	 



Signature Page to Twelfth Supplemental Indenture — 7.875% Notes due 2016








 









 








	 	 	 	 	 
	 	GUARANTORS (continued):



ALERE TOXICOLOGY SERVICES, INC.

LABORATORY SPECIALISTS OF AMERICA,

INC.

SCIENTIFIC TESTING LABORATORIES, INC.

 	 
	 	By:  	/s/ Ellen V. Chiniara
 	 
	 	 	Name:  	Ellen V. Chiniara 	 
	 	 	Title (respectively):  Secretary; Secretary;
Secretary 	 
	 



Signature Page to Twelfth Supplemental Indenture — 7.875% Notes due 2016








 









 








	 	 	 	 	 
	 	TRUSTEE:



THE BANK OF NEW YORK MELLON TRUST 

COMPANY, N.A.,

as Trustee

 	 
	 	By:  	/s/ Raymond K. O’Neil
 	 
	 	 	Name:  	Raymond K. O’Neil 	 
	 	 	Title:  	Senior Associate 	 
	 



Signature Page to Twelfth Supplemental Indenture — 7.875% Notes due 2016