U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Food and Feed Safety Research: College Station, TX
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Plains Area College Station, Texas Southern Plains Agricultural Research Center Food and Feed Safety Research Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            Harvey, Rogeritem
                                            Anderson, Robinitem
                                            Nisbet, David
  Submitted to: American Journal of Veterinary Research
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 3/29/2001
                                    Publication  Date: 12/28/2001
                                    Citation: N/AInterpretive Summary: These studies show that we can take the normal bacteria found in the gut of healthy swine and grow them in the laboratory and then give the bacteria to newborn pigs and protect these pigs from an Escherichia coli infection. The process of growing bacteria in the lab and then giving them to animals to protect against disease-causing bacteria is called  competitive exclusion (CE). The current studies demonstrate that by giving the swine CE culture to newborn pigs, we can reduce the death and disease symptoms associated with E. coli and reduce the possible spread of the E. coli to other pigs. This work is also important because the CE culture used for these studies is readily identified in the laboratory, which means we will have the first defined CE culture for use in the swine industry. Ultimately, the use of this product in swine should result in less expensive and safer swine products for consumers. Being able to  identify the bacteria in a CE culture is necessary for approval of the use of the culture in food animals by the Food and Drug Administration.
                                Technical Abstract: We have previously reported that the administration of a competitive exclusion culture (PCF-1) to neonatal pigs resulted in a decrease in the incidence of fecal shedding and cecal colonization of Salmonella choleraesuis in pigs at weaning.  In the present experiments, we describe the effects of the administration of a derivative of the PCF-1 culture  (RPCF) against an enterotoxigenic E. coli (ETEC) infection in suckling neonatal pigs.  The administration of RPCF to neonatal pigs 12 hours after birth and challenged with 10**9 colony forming unit (CFU) ETEC at 48 hours resulted in significant (P < 0.001) reductions in mortality. In similar experiments using a 10**7 ETEC challenge, significant (P < 0.001) reductions occurred in the numbers and incidence of ETEC in ileal and cecal contents of RPCF-treated pigs when compared to controls.  These results indicate that the RPCF culture is protective against one of the  most important causes of neonatal scours, E. coli infections, in piglets.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov