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Title:   Author  item
                                            Lillehoj, Hyunitem
                                            MIN, WONGI - USDA, ARS, LPSI, IDRL
  Submitted to: American Society for Veterinary Clinical Pathologists
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 1/30/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract:   Recombinant chicken IL-2 promotes the growth of gamma-delta T cells in vitro and enhances the NK-cell activity in chickens.  Stimulation of IL-2-dependent gamma-delta T-cells  with Con A induced IFN-gamma and IL-2  mRNA transcripts whereas stimulation with rIL-2 induced only IFN-mRNA. Subcutaneous injection of rIL-2 DNA to day-old chickens increased the percentage of cells which express the CD8 and TCR antigens in the spleen. Chickens which were orally infected with Eimeria acervulina showed a significant enhancement of IL-2 mRNA transcripts in the spleen and intestine and increased percentage of T-cells in the duodenum following both primary and secondary infections.  These results indicate that host immune responses to E. acervulina involve an up-regulation of IL-2  secretion and an increased duodenum T-cells.      1


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