U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            BABU, U - FDAitem
                                            OKAMURA, M - 1265-40-00item
                                            GAINES, D - FDAitem
                                            MYERS, M - FDAitem
                                            RAYBOURNE, R - FDAitem
                                            Lillehoj, Hyunitem
                                            HECKERT, R - VA-MD REG COL VET MED
  Submitted to: American Veterinary Medical Association Abstract
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 5/1/2002
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: This study was conducted to investigate the differential impact of live and killed Salmonella enteritidis (SE) vaccines on cell-mediated immunity of 16 and 32 week old White Leghorn hens.  The hens were vaccinated with the 2 vaccines and two weeks later CMI was assessed using splenic mononuclear cell proliferation, in response to Con A and antigen and cell subpopulation numbers as indices. Mitogen and SE flagella mediated proliferation and the cell populations were determined by 3H-thymidine uptake and flow cytometry, respectively.  Con-A mediated and the SE flagella mediated proliferation were enhanced in the 16 week old and 32 week old birds vaccinated with live vaccine, compared to the corresponding control birds.  However, Con A-mediated response was higher in the killed vaccine group of only the 16-week old birds compared to the corresponding control birds.  Furthermore, there was a significant increase in the SE-flagella mediated proliferation in the killed vaccine group compared to the control group in case of 32-week old birds. These functional changes were accompanied by some changes in the splenic mononuclear cell subpopulations, which included increased CD4 population in the live vaccine group compared to the control and the killed vaccine groups.  Correspondingly, there was a reduction in the CD8 population in the live vaccine group, compared to the killed vaccine group.  Overall, live vaccine appeared to result in greater functional changes, such as non-specific mitogen and antigen-specific proliferation of splenic lymphocytes compared to the killed vaccine.  This may prove beneficial in protecting hens that are infected with the wild type SE.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov