<PAGE>

EXHIBIT 31.1


          CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED
            PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, James Joyce, certify that:

1.       I have reviewed this Annual Report on Form 10-K of Aethlon Medical,
         Inc.;

2.       Based on my knowledge, this Annual Report does not contain any untrue
         statement of a material fact or omit to state a material fact necessary
         to make the statements made, in light of the circumstances under which
         such statements were made, not misleading with respect to the period
         covered by this Report;

3.       Based on my knowledge, the financial statements, and other financial
         information included in this Report, fairly present in all material
         respects the financial condition, results of operations and cash flows
         of the smaller reporting company as of, and for, the periods presented
         in this report;

4.       The smaller reporting company's other certifying officer(s) and I are
         responsible for establishing and maintaining disclosure controls and
         procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e))
         and internal control over financial reporting (as defined in Exchange
         Act Rules 13a-15(f) and 15d-15(f)) for the smaller reporting compnay
         and have:

         (a)      Designed such disclosure controls and procedures, or caused
                  such disclosure controls and procedures to be designed under
                  our supervision, to ensure that material information relating
                  to the smaller reporting company, including its consolidated
                  subsidiaries, is made known to us by others within those
                  entities, particularly during the period in which this Report
                  is being prepared;

         (b)      Designed such internal control over financial reporting, or
                  caused such internal control over financial reporting to be
                  designed under our supervision, to provide reasonable
                  assurance regarding the reliability of financial reporting and
                  the preparation of financial statements for external purposes
                  in accordance with generally accepted accounting principles;

         (c)      Evaluated the effectiveness of the smaller reporting company's
                  disclosure controls and procedures and presented in this
                  Report and our conclusions about the effectiveness of the
                  disclosure controls and procedures, as of the end of the
                  period covered by this Report based on such evaluation; and


         (d)      Disclosed in this Report any change in the smaller reporting
                  company's internal control over financial reporting that
                  occurred during the smaller reporting company's most recent
                  fiscal quarter (the smaller reporting company's fourth fiscal
                  quarter in the case of an annual report) that has materially
                  affected, or is reasonably likely to materially affect, the
                  smaller reporting company's internal control over financial
                  reporting; and

5.       The smaller reporting company's other certifying officer(s) and I have
         disclosed, based on our most recent evaluation of internal control over
         financial reporting, to the smaller reporting company's auditors and
         the audit committee of the smaller reporting company's board of
         directors (or persons performing the equivalent functions):

         (a)      All significant deficiencies and material weaknesses in the
                  design or operation of internal control over financial
                  reporting which are reasonably likely to adversely affect the
                  smaller reporting company's ability to record, process,
                  summarize and report financial information; and

         (b)      Any fraud, whether or not material, that involves management
                  or other employees who have a significant role in the smaller
                  reporting company's internal control over financial reporting.

Date: July 2, 2009

                                        /S/ JAMES A. JOYCE
                                        -----------------------------
                                        JAMES A. JOYCE
                                        CHIEF EXECUTIVE OFFICER AND
                                        CHIEF ACCOUNTING OFFICER
                                        (PRINCIPAL EXECUTIVE OFFICER AND
                                        PRINCIPAL ACCOUNTING OFFICER)