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Title:   Author  item
                                            Kogut, Michael

                                                         - *Mike*item
                                            Genovese, Kenneth

                                                         - *Ken*item
                                            LOWRY, VIRGINIA - TAMU
  Submitted to: Congress International Society Develop Comparative Immunology
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/17/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Salmonella arizonae (SA) and S. gallinarum (SG) are pathogenic in young poultry.  We have shown that immune lymphokines (ILK), produced by S. enteritidis (SE)-immunized chickens, provide protection against Salmonella infections in day-old poultry.  The objective of the present study was to determine the effect of ILK on the incidence of horizontal transmission of  SA in turkey poults and of SG in broiler chicks assessed in a seeder/contact model.  Seeders were challenged with the appropriate bacterium (SA in turkeys, SG in chicks), and contacts were either untreated or administered ILK.  Mortality and organ invasion of contact birds were observed.  There were no significant differences in mortality between non-treated and ILK-treated contact poults.  In contrast, SG was extremely pathogenic to contact chicks.  Non-treated contact chicks had a mortality rate of approximately 68%, whereas significant (P < 0.05)  reduction in mortality was demonstrated in the contact chicks treated with ILK (15%).  Organ invasion of SA to contact turkey poults and SG to contact broiler chicks was significantly (P < 0.05) decreased by the administration of ILK.  Bacterial recovery of SA or SG from the liver/spleen and cecal tonsil from contact poults and chicks, respectively, was dramatically reduced in the ILK-treated birds when compared to the non-treated contacts.  These results suggest that prophylactic administration of ILK to young turkeys and chickens significantly reduces the horizontal transmission of Salmonella in poultry.  These results also suggest the possibility of using a non- vaccine immunologically-based strategy against Salmonella in poultry.


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