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Title:   Author  item
                                            LIDDELL, SUSAN - 1265-20-00item
                                            Jenkins, Markitem
                                            Dubey, Jitender
  Submitted to: American Association of Veterinary Parasitologists Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 12/1/1999
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Neospora caninum (Nc) is a cyst-forming coccidian that was first identified as causing neurologic disease in canines and now appears to be a significant cause of reproductive failure in dairy cattle worldwide.  The goal of our research is to develop a vaccine for preventing neontal death and abortion by blocking vertical and horizontal transmission of the  parasite to susceptible animals.  A mouse model of congenital bovine neosporosis was developed such that pregnant dams inoculated with Nc tachyzoites produce offspring infected with Nc as demonstrated by a quantitative-competitive PCR (QC-PCR) assay.  Our research showed that infection of pregnant BALB/c mice with Nc tachyzoites at gestation days 11-13 resulted in a highly reproducible infection rate of pups.  This mouse model was used to assess the vaccine efficacy of native and recombinant (NCDG1 & NCDG2) Neospora tachyzoite antigens.  Dissimilar to  adjuvant-immunized controls, neonates born of mothers immunized with nativ tachyzoite antigen 4-6 wks prior to Nc tachyzoite challenge showed no discernable Nc DNA as measured by QC-PCR.  Only partial protection against congenital transfer was observed in offspring of dams immunized with recombinant NCDG1& NCDG2 antigens.  The protection results in the dams was inconclusive. These results suggest that immunization with native Nc tachyzoite antigen can protect against vertical transmission of the parasite and provide a basis for developing a vaccine derived from recombinant DNA-expressed proteins.


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