Exhibit 4.33




AMENDMENT AGREEMENT




As of March 30, 2011

This Amendment Agreement (this “Agreement”) is entered into by and among IASO Pharma Inc. (f/k/a Pacific Beach Biosciences, Inc.), a Delaware corporation (the “Company”), and
each holder of 2010 Notes (as such term is defined below) listed on the signature pages hereto (together with successors and assigns of each, a “Holder,” and collectively, the “Holders”), and solely with respect to Section 3 of this Agreement, Lindsay A. Rosenwald, M.D. 

RECITALS

WHEREAS, each Holder and the Company are parties to a Note and Warrant Purchase Agreement dated as of
February 9, 2010 or March 1, 2010 (collectively, as previously amended, the “Purchase Agreements”), pursuant to which the Company issued and sold to the Holders a series of
like senior convertible promissory notes in the aggregate principal amount of $4,343,000 (collectively, as previously amended, the “2010 Notes”) and a series
of like warrants to purchase shares of the Company’s common stock, par value $0.001 per share (collectively, the “Warrants”); 

WHEREAS, the Company filed a registration statement with the SEC and conducted a road show for a proposed
initial public offering (“IPO”) of the Company’s securities led by Ladenburg Thalmann & Co. Inc.
(“Ladenburg”) in February
2011; however, despite the considerable efforts of all involved, the IPO failed to price and was not consummated;

WHEREAS, the Company has determined that it is in the best interest of the Company and its stockholders to
obtain interim financing and retain its lead asset is to conduct a rights offering
(the “Rights Offering”) to its existing convertible noteholders, including the Holders,
of a new issue of secured convertible notes in the aggregate principal amount of $3,000,000
(the “Rights Offering Notes”),
with each existing convertible noteholder, including the Holders entitled to purchase up to $281 in principal amount of Rights Offering Notes for each $1,000 of
original principal amount of existing convertible notes held by such noteholder. The Rights Offering Notes will be secured by all the assets of the Company and
will be convertible into 100% of the equity of the Company immediately prior to an IPO; provided, however, that the Company will have the right to repay up to
$1 million of the Rights Offering Notes out of the proceeds of an IPO. The terms of the Rights Offering will be more fully described in the Subscription Form
and Subscription Agreement that will be circulated to you once the Requisite Approval (as defined below) is obtained in connection with this Agreement;


WHEREAS, the Rights Offering will be backstopped by Dr. Lindsay A. Rosenwald and Manchester Securities Corp.
(“Manchester”) (or their respective affiliates), the Company’s two largest investors. As compensation for their backstop commitment, Dr.
Rosenwald and Manchester will receive warrant coverage to purchase shares equal to 100% of their backstop commitment amounts; however, Dr. Rosenwald will
assign his backstop warrants to all the existing convertible noteholders of the Company (other than Manchester) on a pro rata basis. The backstop warrants
to be issued to Manchester will contain certain anti-dilution protections that will not be in the warrants to be issued to Dr. Rosenwald. In addition,
following consummation of the Rights Offering, Manchester and Dr. Rosenwald will have the right to consent to any material action taken by the Company prior to
the consummation of an IPO and Manchester will have the right to designate one member of the Company’s board of directors;

WHEREAS, the Rights Offering is
designed as a bridge to a larger financing, ideally an IPO. With respect to the larger financing, the Company has engaged in discussions with OPN Capital
Markets,













a division of National Securities (“OPN”), to act as co-lead underwriter in connection with an IPO. OPN is a joint venture of Opus Point Partners and National Securities. Dr.
Rosenwald is a principal of Opus Point Partners, which is a significant shareholder of National Securities. Based on discussions with OPN and feedback
from Ladenburg, the Company believes it is imperative that the Company effect a recapitalization that permits a lower pre-money valuation to give it the best
chance for successfully completing an IPO. As such, the Company is seeking to effect a substantial recapitalization that would amend, in accordance with
the terms set forth herein, the 2007 Notes along with all the Company’s other existing convertible notes and the Warrants; 

WHEREAS, in connection with the proposed recapitalization and the Rights Offering, all of the Company’s
investor warrants will be terminated and the Company will effect a reverse stock split so that all of the current equity in the Company is effectively
eliminated, and the shares into which the Rights Offering Notes convert will represent substantially all of the capital stock in the Company immediately prior
to the consummation of an IPO. Following the proposed recapitalization and the Rights Offering, the only debt the Company will have outstanding will be
amounts borrowed under its bank line of credit, which amounted to $325,000 as of December 31, 2010 and which is expected to be repaid with the proceeds of an
IPO, and the notes issued to Paramount Credit Partners in the aggregate amount of $2,875,000, which are not convertible and will not be repaid with the proceeds
of an IPO;

WHEREAS, the Company seeks the
consent of the Holders to (a) amend the 2010 Notes to provide that the 2010 Notes will convert into the right to receive Milestone Payments (as defined herein)
upon the consummation of the Rights Offering and (b) amend the Warrants to provide that they will terminate upon the consummation of the Rights Offering, each
on the terms set forth herein, in order to effect the proposed recapitalization and maximize the Company’s ability to complete an IPO; 


WHEREAS, each of the undersigned
Holders agrees to amend the 2010 Notes and the Warrants on the terms set forth herein; and

WHEREAS, such
amendments require the written consent of the Company and the holders of not less than sixty-six and two-thirds
percent (66 2/3%) of the aggregate outstanding principal amount of the 2010 Notes and the holders of not less than sixty-six and two-thirds percent (66 2/3%) of
the Warrant Shares (as defined in the Warrants) then issuable upon exercise of the Warrants (the “Requisite Approval”) pursuant to Section 6.2 of the Purchase Agreements, Section 11 of the Notes and Section 7 of the Warrants.


AMENDMENTS

NOW, THEREFORE, the parties agree as follows:

1.

Amendment to 2010 Notes.
  Section 2 of each of the 2010 Notes is hereby amended to add the following as a new subsection 2.3:

2.3

(a)

Notwithstanding any provision to the
contrary herein, including the provisions contained in Sections 2.1 and 2.2 above, upon the Consummation of a Rights Offering, all unpaid principal and accrued
but unpaid interest on this Note shall be automatically converted into the right to receive the Holder’s Pro Rata Share (as defined below) of the Milestone
Payments (as defined below) set forth in (b) and (c) below.

(b)

Upon the achievement by the Company (or
its Affiliates or Sublicensees) of the milestone events described below (each, a “Development Milestone Event”), the Company shall pay to the
Holder its Pro Rata Share of the milestone









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payment
specified below (each, a “Development Milestone Payment”). The specified Development Milestone Payment shall be made within thirty (30)
days after the occurrence of the related Development Milestone Event. 

		
	Development Milestone Event 

	Milestone Payment


	 

	 


	Successful Completion of first Phase III

Clinical Trial

	$2,500,000


	 

	 


	FDA acceptance for review of first NDA

	$2,500,000


	 

	 


	FDA Final Approval of first NDA

	$5,000,000





(c)

Following the First Commercial Sale of
the Product, the Company shall (i) pay to the Holder, upon the terms and subject to the conditions hereof, the Holder’s Pro Rata Share of the Net Sales
Payment (as defined below) for each calendar quarter until such time as the cumulative Net Sales (as defined below) by the Company and its Affiliates and
Sublicensees reach an aggregate of $150,000,000 and (ii) provide Holder with a statement along with such payment, such statement to be certified by the Chief
Financial Officer of the Company, setting forth the Company’s calculation of both the Net Sales and the Net Sales Payment for such calendar quarter.
 The Net Sales Payment for each calendar quarter shall be made within sixty (60) days after the end of such calendar quarter, but in any event no later
than the date on which the Company makes its quarterly royalty payment based on Net Sales to the Licensor under the License Agreement.

(d)

If the Company is a public reporting
company under the Securities Exchange Act of 1934, as amended, at the time any Milestone Payment is due, the Company may, at its option, issue shares of Common
Stock having a value equal to the amount of such Milestone Payment in lieu of making such Milestone Payment in cash, with such value determined based on the
average closing price of the Common Stock during the twenty (20) Trading Days immediately preceding the date on which such Milestone Payment is due; provided
that (i) such shares of Common Stock are registered under the Securities Act and are issued under an effective registration statement of the Company under the
Securities Act and (ii) all Equity Conditions are satisfied. As soon as practicable, but in no event more than two Trading Days, following the public
announcement by the Company of any Development Milestone Event or earnings for a calendar quarter with respect to which a Net Sales Payment is due
(the “Milestone Payment Notice Date”), the Company shall send to the Holder a written notice (a “Milestone Payment Notice”) that shall
state whether the entire applicable Milestone Payment shall be paid in cash or in shares of Common Stock and if such payment is to be made in shares of Common
Stock, certify that the Equity Conditions are then satisfied. If (x) the Company does not timely send a Milestone Payment Notice to Holder in accordance
with this Section 2.3(d) or (y) the Equity Conditions are not satisfied, then the Company shall be deemed to have delivered a Milestone Payment
Notice electing to pay the entire Milestone Payment in cash. Each Milestone Payment Notice, whether actually given or deemed given, shall be irrevocable.
 Any shares of Common Stock issued pursuant to this Section 2.3(d) shall be delivered to the Holder no later than three (3) Trading Days following
the date on which the applicable Milestone Payment is due.









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(e)

Upon the Consummation of a Rights Offering,
the outstanding unpaid principal and accrued but unpaid interest of the Note shall be converted without any further action by the Holder and whether or not the
Note is surrendered to the Company or its transfer agent, and the indebtedness evidenced by this Note shall be satisfied in full and no interest shall continue
to accrue on this Note and all rights of the Holder hereunder shall terminate. The Company shall not be obligated to issue any certificate or other instrument
evidencing the Holder’s right to receive the Holder’s Pro Rata Share of the Milestone Payments. Any conversion effected in accordance with this
Section 2 shall be binding upon the Holder hereof.

(f)

For purposes of this Section 2.3, the
following terms shall have the following meanings: 

“Affiliate” shall
mean, with respect to any Person, any other Person which directly or indirectly controls, is controlled by, or is under common control with, such Person.
 A Person shall be regarded as in control of another Person if it owns, or directly or indirectly controls, at least fifty percent (50%) of the voting
stock or other ownership interest of the other Person, or if it directly or indirectly possesses the power to direct or cause the direction of the management
and policies of the other Person by any means whatsoever;

“Consummation of a Rights Offering” means the consummation of a Rights Offering on or before June 30, 2011;

“Equity Conditions”
shall mean each of the following: (i) on each day during the Equity Conditions Measuring Period, the shares of Common Stock are designated for listing on
a national securities exchange and shall not have been suspended from trading on such exchange nor shall delisting or suspension by such exchange have been
threatened or pending in writing by such exchange nor shall there be any SEC or judicial stop trade order or trading suspension stop order; (ii) any shares of
Common Stock to be issued in connection with the applicable Milestone Payment may be issued in full without violating the rules or regulations of the national
securities exchange on which they are listed or any applicable laws; (iii) on each day during the Equity Conditions Measuring Period, there shall not have
occurred and be continuing, unless waived by the Holder, either (A) an Event of Default or (B) an event that with the passage of time or giving of notice would
constitute an Event of Default; (iv) on each day during the Equity Conditions Measuring Period, the Company has not provided any Holder with any material
non-public information concerning the Company, except pursuant to a confidentiality agreement between the Company and such Holder; (v) the Company’s
transfer agent for the shares of Common Stock is participating in the DTC Fast Automated Securities Transfer Program; and (vi) all shares of Common Stock to be
issued in connection with the applicable Milestone Payment are duly authorized and will be validly issued, fully paid and non-assessable upon issuance and the
issuance thereof will not require any further approvals of the Company’s board of directors or shareholders.

“Equity Conditions Measuring Period” shall mean the period beginning twenty (20) Trading Days prior to the date of the applicable Milestone Payment and ending on and including such
date.









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“Existing Convertible Notes” shall mean the Bridge Notes (including this Note), the 2010 Notes and the Related Party Notes, which have an aggregate
original principal amount of $10,719,350; 

“FDA” shall mean the
United States Food and Drug Administration or any successor agency;

“FDA Final Approval”
shall mean approval by the FDA that is not conditioned on any other event (or if an approval is conditioned upon an event, then the occurrence of that event),
provided, however, such other events shall specifically not include FDA requirements to conduct post marketing studies and any requirement for such post
marketing studies shall not be deemed to delay the Final Approval;

“First Commercial Sale” shall mean the first sale of the Product after all applicable marketing and pricing approvals (if any) have been granted by the applicable governing
health authority of such country;

“License Agreement”
shall mean the License Agreement dated as of June 12, 2007, between the Licensor and the Company, pursuant to which the Company licensed certain rights to the
Product, as the same may be amended from time to time;

“Licensor” shall mean
Dong Wha Pharm. Co. Ltd., a Korean corporation, or its successor;

“Milestone Payments”
shall mean the Development Milestone Payments and the Net Sales Payments;

“NDA” shall mean a New
Drug Application, or similar application for marketing approval of the Product submitted to the FDA;

“Net Sales” shall
mean, with respect to the Product, the gross sales price of the Product invoiced by the Company or its Affiliate to customers who are not Affiliates (or are
Affiliates but are the end users of the Product) less, to the extent actually paid or accrued by the Company or its Affiliate (as applicable), (a) credits,
allowances, discounts and rebates to, and chargebacks from the account of, such customers for nonconforming, damaged, out-dated and returned Product;
(b) freight and insurance costs incurred by the Company or its Affiliate (as applicable) in transporting the Product to such customers; (c) cash,
quantity and trade discounts, rebates and other price reductions for the Product given to such customers under price reduction programs; (d) sales, use,
value-added and other direct taxes incurred on the sale of the Product to such customers; (e) customs duties, tariffs, surcharges and other governmental
charges incurred in exporting or importing the Product to such customers; and (f) an allowance for uncollectible or bad debts determined in accordance with
generally accepted accounting principles;

“Net Sales Payment”
shall mean, for any calendar quarter, an amount equal to fifteen percent (15%) of Net Sales of the Product by the Company and its Affiliates during such
calendar quarter; provided that the Net Sales Payment for the calendar quarter during which the cumulative Net Sales by the Company and its Affiliates and
Sublicensees reach $150,000,000 shall be prorated to apply only to Net Sales during the period up to such time that such cumulative Net Sales amount is
achieved;









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“Person” shall mean an individual, corporation, partnership, limited liability company, trust, business trust, association, joint stock company,
joint venture, pool, syndicate, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed
herein;

“Phase III Clinical Trial” shall mean a human clinical trial in any country, the results of which could be used to establish safety and efficacy of the Product as a basis for
an NDA or would otherwise satisfy requirements of 21 C.F.R. 312.21(c);

“Pro Rata Share” shall
mean, with respect to any Milestone Payment, the Holder’s pro rata share of such Milestone Payment based on the original principal amount of this Note
relative to the aggregate original principal amount of all Existing Convertible Notes;

“Product” shall mean
the Company’s lead product candidate known as PB-101 (zabofloxacin);

“Rights Offering”
means a rights offering to the holders of the Existing Convertible Notes of a new issue of secured convertible notes in the aggregate principal amount of
$3,000,000;

“Sublicensee” means
any Third Party to whom the Company grants rights to use some of the Company’s rights under the License Agreement;

“Successful Completion” shall mean that the Phase III Clinical Trial (a) achieved its primary clinical endpoint as defined in the protocol for the Phase III Clinical
Trial and (b) had a side effect profile that does not adversely affect the Product’s eligibility to be subject to an NDA; and

“Third Party” shall
mean any Person other than the Company, the Licensor and their respective Affiliates.

“Trading Day” shall
mean a day on which the shares of Common Stock are traded on a national securities exchange, or, if the Common Stock are not so traded, a business day.

2.

Amendment to Warrants. Section 1 of
each of the Warrants is hereby amended to insert the following language as the last sentence of the first paragraph of Section 1 (immediately prior to the
beginning of Section 1(a)): 

Notwithstanding the foregoing and anything to the
contrary herein, in the event that the Company consummates a rights offering to the holders of the its existing convertible notes of a new issue of secured
convertible notes in the aggregate principal amount of $3,000,000 (the “Rights Offering”) on or before June 30, 2011, this Warrant shall automatically
terminate and be of no further force or effect, without any further action on the part of the Company or the Holder, upon the closing of the Rights Offering.


3.

Consent. The undersigned hereby
consents to the amendment to the 2010 Notes and the Warrants as set forth in Sections 1 and 2 hereof. 









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4.

Assignment of Rights to Backstop Warrants upon
Consummation of Rights Offering. As an inducement for the Holders’ consent to the amendments to the 2010 Notes and the Warrants as set forth
in Sections 1 and 2 hereof, Lindsay A. Rosenwald, M.D. hereby agrees to assign all warrants he is entitled to receive as compensation for his backstop
commitment in connection with the Rights Offering to the Holders and the holders of the 2007 Notes (as defined in the 2010 Notes) (other than those Holders or
holders of 2007 Notes that are affiliates of Dr. Rosenwald or Manchester Securities Corp.) pro rata based on the original principal amount of each 2010
Note and 2007 Note relative to the aggregate original principal amount of the 2010 Notes and the 2007 Notes combined (excluding any 2010 Notes or 2007 Notes
that are held by affiliates of Dr. Rosenwald or Manchester Securities Corp.). 

5.

Effectiveness. This Agreement shall
be effective upon obtaining the signatures below of the Company, Dr. Rosenwald and the Requisite Approval; provided, however, that such effectiveness shall be
conditioned upon amendment agreements providing for the same amendments to the 2007 Notes and the Related Party Notes (each as defined in the 2010 Notes) as
those set forth in Section 1(b) above having become effective. 

6.

Representations and Warranties of the Holders.
 Each of the Holders party hereto hereby represents and warrants to the Company that: 

(a)

the Holder is the lawful holder of the 2010 Note designated on the
signature page hereto free and clear of all security interests, claims, liens, pledges, conditional sales contracts, attachments, judgments and encumbrances of
every kind and nature, including restrictions, or rights of any third parties;




(b)

the Holder has the requisite power and authority to execute and
deliver this Agreement, to perform the Holder’s obligations hereunder and to engage in the transactions contemplated hereby;




(c)

the Holder has taken all requisite action to make all the
provisions of this Agreement the valid and enforceable obligations they purport to be; 




(d)

this Agreement constitutes the valid and binding obligation of the
Holder, enforceable in accordance with its terms, subject to laws of general application from time to time in effect affecting creditors' rights and the
exercise of judicial discretion in accordance with general equitable principles;




(e)

the Holder has read this Agreement and the Company’s letter to
the Holders dated March 30, 2011, and the Holder fully understands the terms of the proposed recapitalization, including the amendments to the 2010 Notes
pursuant to this Agreement, and the Rights Offering, as described in this Agreement and such letter.




7.

Representations and Warranties of the Company.
 The Company hereby represents and warrants to the Holders that: 

(a)

it has the requisite power and authority to execute and deliver
this Agreement, to perform its obligations hereunder and to engage in the transactions contemplated hereby;




(b)

it has taken all requisite action to make all the provisions of
this Agreement the valid and enforceable obligations they purport to be; 









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(c)

this Agreement constitutes its valid and binding obligation,
enforceable in accordance with its terms, subject to laws of general application from time to time in effect affecting creditors' rights and the exercise of
judicial discretion in accordance with general equitable principles; and




(d)

neither the execution, delivery or performance of this Agreement
nor the consummation of the transactions contemplated hereby violates, conflicts with, constitutes a default under, results in the acceleration of or creates in
any party the right to accelerate, terminate, modify or cancel any material contract to which it is a party or by which it is bound.




8.

Miscellaneous

(a)

This Agreement may be executed in two or
more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed
by each party and delivered to the other party, it being understood that the parties need not sign the same counterpart.  In the event that any signature
is delivered by facsimile transmission, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is
executed) with the same force and effect as if such facsimile signature page were an original thereof. 

(b)

This Agreement shall be governed by the
law of the State of New York without giving effect to any principles or conflicts of law. 

(c)

Except as expressly amended hereby, the
terms of the 2010 Notes and the Warrants shall remain in full force and effect.

(d)

Each party shall do and perform, or cause
to be done and performed, all such further acts and things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as
the other party may reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions
contemplated hereby.

(e)

Existing references to any of the 2010
Notes are henceforth deemed references to the 2010 Notes as amended by this Agreement and existing references to any of the Warrants are henceforth deemed
references to the Warrants as amended by this Agreement.

(f)

If any provision or portion of this
Agreement shall be determined to be invalid or unenforceable for any reason, in whole or in part, the remaining provisions of this Agreement shall be unaffected
thereby and shall remain in full force and effect to the fullest extent permitted by law.

(g)

The headings contained in this Agreement
are for reference purposes only and shall not be deemed to be part of this Agreement or to affect the meaning or interpretation of this Agreement.

(h)

All of the terms and provisions of this
Agreement shall bind and inure to the benefit of the parties hereto and their respective successors and assigns.

(i)

This Agreement is intended for the
benefit of the parties hereto and their respective permitted successors and assigns, and is not for the benefit of, nor may any provision hereof be enforced by,
any other person or entity.

[Remainder of page intentionally left blank]









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IN WITNESS WHEREOF, the parties hereto have caused this
Agreement to be duly executed by their respective authorized signatories as of the date first indicated above. 

				
	 
	


IASO PHARMA INC.


	  

	  


	  

	 


	  

	By: 

	/s/ Matthew A.
Wikler


	  

	Name: 

	 Matthew A. Wikler, M.D.


	  

	Title: 

	 President and CEO


	 
	 
	 
	 



  

		
	  

	


LINDSAY A. ROSENWALD, M.D., solely with respect to Section 4 of this Agreement


	  

	  


	 
	 

	  

	/s/ Lindsay A. Rosenwald



	  

	 Lindsay A. Rosenwald, M.D.


	  

	  







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	Principal Amount of Note: $____________________ 

	 HOLDER: 


	  

	  


	  

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2010 Notes Amendment Agreement Signature Page (Continued)