CONFIRMATION
OF PURCHASE

March 10, 2006

Genta
Incorporated Two Connell Drive  Berkeley Heights, New Jersey 07922

| | Re: |  | Subscription
Agreement, dated March 6, 2006 (the  Subscription Agreement), between the
undersigned (the Investor)  and Genta Incorporated, a Delaware corporation
(the Company)
| | --- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Ladies and
Gentlemen:

This letter is
to confirm the undersigned Investors agreement with the  Company as follows
(capitalized terms used herein and not otherwise  defined shall have the meanings set
forth in the Subscription  Agreement):

|1. |  | The
Investor entered into the Subscription  Agreement  pursuant  to  which,  subject  to the
satisfaction  of  certain  closing  conditions  by the  Company,  the  Investor  agreed
to purchase  from the Company,  and the Company  agreed to issue and sell to  the
Investor,  the  Shares  of  Common  Stock set forth in the  Subscription  Agreement  for
the aggregate  purchase  price set  forth therein.
|-- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|2. |  | The
Closing Date for the sale of the Shares had been scheduled  for Friday, March 10, 2006;
however, the Company now desires  to reschedule the Closing Date to Monday, March 13,
2006.
|-- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|3. |  | The
Investor  acknowledges  that it has received a copy of the  Companys  Annual Report
on Form 10-K for the fiscal year ended  December 31, 2005 filed on March 10, 2006,  which
contains new,  additional  or  changed  information  the  Investor  may  deem  relevant
in making its investment  decision,  and confirms that  it  has  had an  opportunity  to
review  such  Annual  Report,  including the risk factors set forth therein.
|-- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|4. |  | The
Company  has  agreed  that  the  Investor  may,  in  its  discretion,  terminate its
commitment  under the  Subscription  Agreement  and not proceed  with the  Offering and
the purchase  of the Shares.  The  Investor  agrees that it has  reconsidered  its
purchase commitment pursuant to the Subscription  Agreement  based on its review of the
Annual  Report,  and has  elected to  take the action indicated below.
|-- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|5. |  | By
initialing the appropriate box below, the Investor hereby  elects as follows:
|-- |  | --------------------------------------------------------------------------------

| | The
      Investoragrees to proceed with the Offering and purchase of the
      Shares on March 13, 2006 in accordance with all the other terms set forth
      in the Subscription Agreement |  | The
      Investor does not agree to proceed with the Offering and terminates
      the Subscription Agreement
| | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | --------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                               |  |                                                                                                               
| | o                                                                                                                                                                                             |  | o                                                                                                             

|6. |  | The
Investor  understands and agrees that Cowen & Co,  LLC  and  Rodman  & Renshaw,
LLC,  the  Placement  Agents  for the  Offering,  and  the  Company  will  be  relying
upon  this  Confirmation in proceeding with the Closing.
|-- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



---

The undersigned
Investor and Genta Incorporated have executed this  Confirmation of Purchase.

| | GENTA
      INCORPORATED         |  |                                       
| | -------------------------------- |  | --------------------------------------
| |                                  |  | ____________________________________  
| |                                  |  | INVESTOR                              
| |                                  |  |                                       
| | By:___________________________   |  | By: _________________________________ 
| | Name:_________________________   |  | Print Name:___________________________
| | Title:__________________________ |  | Title:________________________________
| |                                  |  | Address:_____________________________ 
| |                                  |  | _____________________________         
| |                                  |  | Date: March __, 2006