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Title:   Author  item
                                            YUN, CHEOL - NIH BETHESDA MDitem
                                            Lillehoj, Hyunitem
                                            Zhu, Jamesitem
                                            MIN, WONGI - USDA, ARS, LPSI, IDRL
  Submitted to: American Association of Veterinary Parasitologists Proceedings
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 4/3/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: Recombinant chicken interleukin-2 (IL-2) promotes the growth of T cells in vitro and enhances NK-cell activity in chickens.  Stimulation of IL-2- dependent T-cells with Con A induced interferon-gamma (IFNg) and IL-2 mRNA transcripts whereas stimulation with rIL-2 induced only IFN-mRNA. Subcutaneous injection of rIL-2 RNA to day-old chickens increased the  percentage of cells which express the CD8 and TCR antigens in the spleen. Chickens which were orally infected with Eimeria acervulina showed a significant enhancement of IL-2 mRNA transcripts in the spleen  and intestine and increased percentage of T-cells in the duodenum following both primary and secondary infections.  These results indicate that host immune responses to E. acervulina involve an up-regulation of IL-2 secretion and an increased duodenum T-cells.     1


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