[Federal Register Volume 60, Number 50 (Wednesday, March 15, 1995)]
[Notices]
[Pages 13977-13978]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 95-6409]



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ENVIRONMENTAL PROTECTION AGENCY
[OPP-00367A; FRL-4942-1]


Dermal Absorption Studies of Pesticides; Availability of 
Guideline

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of availability.

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SUMMARY: This notice announces the availability of the guideline for 
Dermal absorption Studies of Pesticides. This guideline is part of 
Subdivision F of the Pesticide Assessment Guidelines, which provide 
guidance for registrants in the conduct of tests to support 
registration of pesticides under the Federal Insecticide, Fungicide, 
and Rodenticide Act (FIFRA). The Agency has made arrangements for the 
Dermal Absorption of Pesticides guideline to be made 
[[Page 13978]] available through the U.S. Department of Commerce, 
National Technical Information Service (NTIS).

ADDRESSES: Copies of the guideline for Dermal Absorption of Pesticides 
may be obtained through the U.S. Department of Commerce, National 
Technical Information Service, 5285 Port Royal Road, Springfield, 
Virginia 22161, (703) 487-4650. Orders may be placed by telephone to 
the NTIS Order Desk and charged against a deposit account or American 
Express, VISA, or Mastercard, or sent by mail with check, money order, 
or deposit account number. For rush orders, telephone 1-800-336-4700. 
From Virginia, Canada, Mexico, or International, call (703) 487-4650. 
The publication number is PB 95-148615.
FOR FURTHER INFORMATION CONTACT: Robert P. Zendzian, Health Effects 
Division (7509C), Office of Pesticide Programs, U.S. Environmental 
Protection Agency, 401 M St., SW., Washington, DC 20460. (703) 305-
5495).
SUPPLEMENTARY INFORMATION: Under the Federal Insecticide, Fungicide, 
and Rodenticide Act (FIFRA) pesticides must be tested for a variety of 
health effects. Specific data requirements are codified in 40 CFR part 
158. Guidelines for the conduct of such studies have been developed by 
the Office of Pesticide Programs and are made available through the 
National Technical Information service (NTIS). The Pesticide Assessment 
guidelines, Subdivision F, describe protocols for performing toxicology 
and related tests to support registration of pesticides under the 
Federal Food, Drug, and Cosmetic Act and the Federal Insecticide, 
Fungicide, and Rodenticide Act.
    Subdivision F was proposed for public comment in 1978 and published 
in October 1982. At that time the Agency published criteria for 
performing a dermal absorption study on a pesticide and reserved a line 
item, section 85-3, for a guideline on Dermal Absorption Studies of 
Pesticides. The Agency had available a protocol for dermal absorption 
studies but did not consider it ready for publication. Following 9 
years of experience with studies on the dermal absorption of 
pesticides, a proposed guideline for Dermal Absorption Studies of 
Pesticides was made available for public comment by publication in the 
Federal Register of March 13, 1991 and a revised proposed guideline in 
the Federal Register of October 21, 1993. The revised proposed 
guideline was presented to the FIFRA Scientific Advisory Panel on 
December 15, 1993 at a public meeting. This final guideline for Dermal 
Absorption studies of Pesticides incorporates comments of the public 
and the FIFRA Scientific Advisory Panel. It is specifically designed to 
assist in the risk assessment of pesticide exposure by the dermal 
route, following the determination of a significant toxic effect in 
toxicology studies performed by the oral or inhalation route.

    Dated: February 27, 1995.

Stephanie R. Irene,
Acting Director, Health Effects Division, Office of Pesticide Programs.
[FR Doc. 95-6409 Filed 3-14-95; 8:45 am]
BILLING CODE 6560-50-F