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ARS Home Northeast Area Beltsville, Maryland (BHNRC) Beltsville Human Nutrition Research Center Food Composition and Methods Development Laboratory Research Publications at this Location





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Title:   Author  item
                                            Pawlosky, Robertitem
                                            Novotny, Janetitem
                                            HIBBELN, JOSEPH - NIHitem
                                            SALEM, JR, NORMAN - NIH
  Submitted to: Journal of Lipid Research
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 4/5/2001
                                    Publication  Date: 12/1/2001
                                    Citation: Pawlosky, R.J., Novotny Dura, J., Hibbeln, J., Salem, Jr, N. 2001. A physiologic compartmental analysis of alpha-linolenic acid metabolism    in adult humans. Journal of Lipid Research. 42(8):1257-1265Interpretive Summary:   The American Heart Association has recommended increasing   the dietary intake of the long-chain omega-3 fatty acids,   docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid   (20:5n-3) because of their well established benefits to   cardiovascular health. These fatty acids are found in fish    and seafoods, which do not make up a regular part of a   "typical" American diet.  For the majority of Americans, the   biosynthesis of long-chain n-3 polyunsaturated fatty acids   from linolenic, 18:3n-3, is a major contributor to the   body's supply of 20:5n-3 and 22:6n-3.   An accurate model of   linolenic acid metabolism in humans based on direct data   obtained from an isotope tracer is needed.   A compartmental   model was derived from the plasma concentration-time curves    for d5-18:3n-3, d5-20:5n-3, d5-22:5n-3, and d5-22:6n-3 in   eight healthy subjects.  The model predicted that only about   0.2% of the plasma 18:3n-3 was destined for synthesis of   20:5n-3.  The inefficiency of the conversion of 18:3n-3 to   20:5n-3 indicates that the biosynthesis of long-chain n-3   PUFAs from linolenic acid is very limited in healthy   subjects and in order to obtain these fatty acids, Americans   should increase their intake of fish and seafoods.
                                Technical Abstract:   The American Heart Association has recommended increasing   the dietary intake of the long-chain omega-3 fatty acids,   docosahexaenoic acid (22:6n-3) and eicosapentaenoic acid   (20:5n-3) because of their well established benefits to   cardiovascular health. These fatty acids are found in fish    and seafoods, which do not make up a regular part of a   "typical" American diet.  For the majority of Americans, the   biosynthesis of long-chain n-3 polyunsaturated fatty acids   from linolenic, 18:3n-3, is a major contributor to the   body's supply of 20:5n-3 and 22:6n-3.   An accurate model of   linolenic acid metabolism in humans based on direct data   obtained from an isotope tracer is needed.   A compartmental   model was derived from the plasma concentration-time curves    for d5-18:3n-3, d5-20:5n-3, d5-22:5n-3, and d5-22:6n-3 in   eight healthy subjects.  The model predicted that only about   0.2% of the plasma 18:3n-3 was destined for synthesis of   20:5n-3.  The inefficiency of the conversion of 18:3n-3 to   20:5n-3 indicates that the biosynthesis of long-chain n-3   PUFAs from linolenic acid is very limited in healthy   subjects and in order to obtain these fatty acids, Americans   should increase their intake of fish and seafoods.


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