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Title:   Author  item
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*item
                                            FRITSCHE, K - UNIVERSITY OF MISSOURIitem
                                            SPENCER, J - UNIVERSITY OF MISSOURIitem
                                            GAINES, A - UNIVERSITY OF MISSOURIitem
                                            ALLEE, G - UNIVERSITY OF MISSOURIitem
                                            Matteri, Robertitem
                                            KATTESH, H - UNIVERSITY OF TENNESSEEitem
                                            ROBERTS, M - UNIVERSITY OF TENNESSEEitem
                                            BEAUSANG, L - PIERCE-ENDOGEN, INC.item
                                            ZANNELLI, M - PIERCE-ENDOGEN, INC.
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 3/19/2001
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: This study evaluated the potential immunological benefit of adding fish oil to the weaned pig's diet. Twenty-four crossbred male pigs were weaned at 18.7+/.13d of age and placed on a nursery diet containing 6% corn oil as the fat source (Cont, n=12) or 5% fish oil and 1% corn oil as the fat source (FO, n=12) for a period of 15d. Body weights did not differ between  the two dietary groups either at the beginning or end of the study. On d 1 pigs received an i.v. injection of either saline (n=6 pigs/dietary group) or lipopolysaccharide (LPS; 150 ug/kg body weight; n=6/dietary group), and blood samples were collected at 30-min intervals for 5h. Serum was harvested for analysis of cortisol (CS), corticosteroid-binding globulin (CBG), tumor necrosis factor-alpha (TNF) and interferon gamma (IFN). A time x treatment x diet interaction (P=.023) was observed for serum CS such that those pigs which consumed the FO diet followed by LPS treatment had a  reduced CS response compared to the LPS treated pigs on the Cont diet. A time x treatment interaction (P=.0048) was observed for serum CBG such that LPS treatment reduced CBG as compared to the saline treated pigs. Time x treatment x diet interactions were also observed for serum TNF (P=.084) and IFN (P=.022) such that both the TNF and IFN response to the LPS challenge was lower in those pigs receiving the FO diet. Serum CS was negatively correlated with the CBG response (r = -.40, P<.0001), however, the strongest negative correlation was observed in the LPS treated pigs which consumed the FO diet (r = -.63, P<.0001). While further studies are needed to evaluate the immunologically beneficial effect of fish oil in the nursery pig diet, the present study demonstrates that fish oil does indeed alter the immunological response to an LPS challenge.


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