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Title:   Author  item
                                            MADDOCK, K - UNIVERSITY OF MISSOURIitem
                                            BERG, E - UNIVERSITY OF MISSOURIitem
                                            ZANNELLI, M - ENDOGEN, INC.item
                                            BEAUSANG, L - ENDOGEN, INC.item
                                            STAHL, C - UNIVERSITY OF MISSOURIitem
                                            LINVILLE, M - UNIVERSITY OF MISSOURIitem
                                            Carroll, Jeffery

                                                         - *Jeff Carroll*
  Submitted to: Journal of Animal Science Supplement
                                    Publication Type: Abstract Only
                                    Publication Acceptance Date: 7/28/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary:
                                Technical Abstract: The objective of this study was to determine if supplementation of alpha-lipoic acid (LA) to neonatal pigs has benefits to immune function, feed conversion, and gain.  Fourteen weaned gilts (d 21, 7.06 kg) were randomly allotted to 2 treatments, no LA (CON; n=7) and 56 mg (LA; n=7) of LA/pig/d.  Pigs were individually penned and treatments were administered  orally for 11 d.  Feed intake and body weights were recorded.  On d 11, th pigs were nonsurgically fitted with jugular cannulae.  On d 12, the pigs received a dose of 150 ug/kg of lipopolysaccharide (LPS).  Blood samples were collected at 15 min intervals for 30 min prior to the LPS challenge and for 3 h after to monitor serum cortisol, glucose, tumor necrosis factor-alpha, interferon gamma, % Neutrophils (N), and % Lymphocytes (L). Serum cortisol showed a time by treatment interaction (P=0.08), such that, while serum cortisol increased in both groups between 15 and 135 min post  LPS, LA pigs showed a less dramatic increase.  Serum glucose showed an overall treatment effect (P=0.007) where serum glucose was higher in LA pigs at basal concentrations and throughout the LPS challenge.  In both groups, serum glucose increased between 0 and 90 min post LPS, and then decreased for both groups.  Percentages of N and L showed a time by treatment effect (P=0.04 and P=0.02, respectively).  Basal %N was 40.9 and decreased in CON post LPS to 14% and increased in LA pigs to 43.25%.  Basal %L was 51.9 and increased in CON post LPS to 81% and decreased in LA pigs to 49.25%.  LA was shown to help maintain neutrophil and lymphocyte populations following an acute LPS challenge suggesting that LA may be beneficial as a feed supplement to enhance neonatal health.


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