U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Geospatial and Environmental Epidemiology Research Unit: Mississippi State, MS
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    CareersSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Southeast Area Mississippi State, Mississippi Geospatial and Environmental Epidemiology Research Unit Research





- Gowda, Prasanna
- 2023
- Animal Health (103)
- Water Availability and Watershed Management (211)
- Plant Diseases (303)

Research Project: **Location:
                            Geospatial and Environmental Epidemiology Research Unit** Project Number: 6064-32000-001-000-D
                        
                        Project Type: In-House Appropriated Start Date: Oct 1, 2022
                        
                        End Date: Sep 30, 2027 **Objective:**
                        
                        1. Develop the data sets and analysis pipelines needed for predicting and modeling the emergence of new pathogens. 
1.A. Integrated predictive modeling capability for emerging infectious diseases of animals and the collection of data to support these models. 
1.B. Comprehensive maps of virus-host interactions required for pathogens to adapt to new hosts. 
1.C. Identification of molecular determinants that enable emerging pathogens to infect new animal hosts, including humans.
1.D. Three-dimensional epidemiological information, integrating metagenomics with climatic and ecological data. 
1.E. Multi-scale big-data integration models for predicting the emergence of new pandemic pathogens.
1.F. Determine quantifiable species-specific transmission parameters of emerging pathogens for modeling and outbreak preparedness.
1.G. Methods to rapidly detect and characterize the etiology of new and emerging diseases.
1.H. Develop standardized systems for data collection and integrative analysis.
1.I. Conduct the molecular characterization of emerging pathogens including phylogenetic analysis and network analysis.
1.J. Conduct large-scale genomic sequencing to improve the surveillance of mutations that lead to new pathogenic variants. 
1.K. Develop integrated techniques from spatiotemporal epidemiology, ecophylogenetics, and distributional ecology. **Approach:**
                        
                        Our capability to rapidly identify, characterize, control, and eradicate new emerging animal pathogens is not well developed. Accordingly, emphasis will be given to filling gaps in our toolbox for predicting the emergence of new pathogens. For example, the inclusion of climatic and ecological information during disease outbreaks is nascent or rarely included in predictive models as it requires access to supercomputing capability for analysis of large data sets. The pathogen-host molecular interactome, consisting in part of protein-protein or nucleic acid-protein interactions, have yet to be deciphered. Environmental parameters that may affect virus-host molecular interactions and/or contribute to epigenetic effects is another significant gap in our knowledge base. Research will be conducted to identify mechanisms of disease, disease transmission, and host range specificity to determine the prevalence and emerging potential of new diseases.  Ultimately, this research will lead to predictors of disease emergence and disease outbreaks and the development of the appropriate intervention strategies.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov