U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Northeast Area Beltsville, Maryland (BHNRC) Beltsville Human Nutrition Research Center Food Components and Health Laboratory Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            Novotny, Janetitem
                                            Rumpler, Williamitem
                                            Baer, Daviditem
                                            Judd, Joseph
  Submitted to: Alcohol and Alcoholism
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 1/16/2003
                                    Publication  Date: 7/1/2003
                                    Citation: Novotny Dura, J., Rumpler, W.V., Baer, D.J., Judd, J.T. 2003. The effect of daily alcohol intake on breath alcohol concentrations of post-menopausal women after a bolus dose. Alcohol and Alcoholism. 64:380-383.Interpretive Summary: Many studies have been conducted to evaluate the effect of external factors on blood alcohol clearance rate, including the influence of chronic alcohol intake. Clarification of this relationship will allow us to fully understand how chronic alcohol intake influences diseases, such as breast cancer, which occur more frequently in drinkers. Record/recall  studies have suggested that habitual alcohol intake increases rate of alcohol elimination from blood. We have expanded on previous studies by adapting non-alcoholic post-menopausal women to 0, 1, or 2 drinks per day for 8 weeks. At the end of the adaptation period, alcohol clearance rates were measured using a test dose.  Analysis showed that adaptation to alcohol intake of 2 drinks per day resulted in more rapid clearance of alcohol from blood than adaptation to 0 or 1 drink per day. These results will be useful to scientists studying the mechanisms behind the  association of alcohol and disease risk.
                                Technical Abstract: This study was designed to test the effect of chronic alcohol intake on blood alcohol levels and alcohol clearance rate in post-menopausal women. Fourteen women completed a study in which they consumed an alcohol treatment daily for 8 weeks.  Following the 8-week adaptation period, subjects consumed a single dose of 15 g ethanol, and breath samples were  collected every 5 minutes until blood alcohol concentration (BAC) decreased to zero.  Analysis of BAC at the different adaptation levels showed that alcohol clearance rate was influenced by chronic intake of alcohol.  Adaptation to daily alcohol intake of 30 g/d resulted in more rapid clearance of alcohol from blood than adaptation to 15 g/d or 0 g/d. Further, there appeared to be a minimum threshold level for chronic alcohol intake above 15 g/d which results in the accelerated clearance of blood alcohol.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov