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Title:   Author  item
                                            HEYEN, D - UNIV OF ILLINOISitem
                                            WELLER, J - INSTITUTE OF ANIMAL SCIitem
                                            RON, M - INSTITUTE OF ANIMAL SCIitem
                                            BAND, M - UNIV OF ILLINOISitem
                                            BEEVER, J - UNIV OF ILLINOISitem
                                            FELDMESSER, E - INSTITUTE OF ANIMAL SCIitem
                                            DA, Y - UNIV OF ILLINOISitem
                                            Wiggans, Georgeitem
                                            Vanraden, Paulitem
                                            LEWIN, H - UNIV OF ILLINOIS
  Submitted to: Genomics
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 10/15/1999
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for  effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design  to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.
                                Technical Abstract: A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for  effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design  to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.


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