EXHIBIT 10.1



EXECUTIVE EMPLOYMENT AGREEMENT



This EXECUTIVE EMPLOYMENT AGREEMENT (the Agreement), is entered
into as of August 3, 2004, by and between POZEN Inc. (the Company), with offices located at Suite 400, 1414 Raleigh Road, Chapel Hill, North Carolina 27517, and William L. Hodges (Executive), whose address is 401 May Court,
Raleigh, North Carolina 27609.



WITNESSETH:



WHEREAS, the Company is engaged in certain pharmaceutical research,
development and marketing activities; and



WHEREAS, the Company
wishes to employ Executive in the position of Senior Vice President, Finance and Administration and Chief Financial Officer, and Executive desires to accept such employment with the Company.



NOW, THEREFORE, in consideration of the foregoing and the provisions and
mutual promises herein contained and other good and valuable consideration, the parties hereby agree as follows:



1. EMPLOYMENT. The Company hereby employs Executive, and Executive hereby accepts employment, as Senior Vice President, Finance and Administration and
Chief Financial Officer of the Company, with such duties and responsibilities as are normally related to such position in accordance with the standards of the industry and as specified in Exhibit A, attached hereto and incorporated herein by
reference, and any additional duties as may be assigned to Executive from time to time by the President or the Board of Directors of the Company.



2. TERM. Executives employment shall be for a term of one (1) year from the date of execution of this Agreement (the Term), and
thereafter shall be automatically renewed with additional one (1) year terms to follow consecutively, subject to the termination and severance provisions herein later provided, unless amended or modified by mutual agreement of the parties. As used
herein, Term shall include the Initial Term and any renewals thereof in accordance with this Agreement.



3. EXCLUSIVE SERVICE. Executive agrees to devote Executives full time and attention to the performance of Executives duties and
responsibilities on behalf of the Company and to comply with all policies and regulations of the Company.



4. COMPENSATION. During the Term of this Agreement, Executives compensation shall be determined and paid as follows:



(a) Base Salary. Executive shall receive an annual
base salary of at least Two Hundred and Thirty Thousand Dollars ($230,000) payable in accordance with the



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Companys payroll practices. Annual increases will be made, if any, based upon performance, and in
the sole discretion of the Board of Directors or the Compensation Committee of the Board of Directors (each or collectively, the Committee), such increases, if any, to be effective as of January 1 of each year during the Term.



(b) Bonus. Executive shall be eligible
to receive an annual cash incentive bonus of up to forty percent (40%) of Executives annual base salary as may be set by the Committee by March 31 of each year. The determination of the actual bonus earned, if any, shall be at the sole
discretion of the Committee and shall be based upon the Committees assessment of Executives performance and the achievement of certain objectives which shall be set by the Committee from time to time. Executives performance shall
be evaluated by the Committee on an annual basis, and the Committee shall adjust Executives salary in its sole discretion. Nothing in this section shall be construed as guaranteeing Executive a bonus in any amount.



(c) Stock Options. Subject to the approval of the
Committee, upon the commencement of Executives employment with the Company, Executive shall be granted an option to purchase Eighty Thousand (80,000) shares of the common stock of the Company at a purchase price equal to closing price of the
common stock of the Company as quoted on the NASDAQ Stock Market on the date of grant. Such shares shall vest in accordance with and be governed by the terms of the Companys 2000 Equity Compensation Plan, as amended and restated, and an
Incentive Stock Option Agreement issued in accordance therewith.



(d) Benefits. Executive shall be eligible to participate in the Companys standard employee benefit programs made available to employees of the Company from time to time, subject to appropriate premium
contributions, benefit elections, etc. In addition, Executive shall be entitled to three (3) weeks of paid vacation per year.



(e) Business Expenses. The Company shall reimburse Executive for all reasonable expenses incurred in the furtherance of the
Companys business and interests, including travel and entertainment. Executive agrees to comply with the expense reporting policies and procedures of the Company.



(f) Adequate Office Space. The Company shall provide to Executive adequate office space, facilities,
and administrative support appropriate to Executives position.



5. TERMINATION. This Agreement shall or may be terminated, as the case may be, upon the terms and conditions hereinafter provided.



(a) Voluntary Termination. This Agreement shall be considered voluntarily terminated by the parties if either party provides
written notice of such partys intent not to renew this Agreement, provided that such party shall provide at least ninety (90) days written notice to the other party prior to the last day of the Initial Term or any renewal term.



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(b) Involuntary Termination. The Company may terminate this Agreement upon written
notice to Executive (or Executives representative) in any of the following events:



| | (i) | The death of Executive;
| | --- | -----------------------



| | (ii) | Executive becomes permanently disabled; or
| | ---- | ------------------------------------------



| | (iii) | For Cause, immediately upon written notice to Executive. Cause shall be determined by the Board of Directors and shall mean: (A) breach by Executive of the terms of this
Agreement; (B) breach of the Nondisclosure, Inventions and Non-Competition Agreement (described in Section 6 below); (C) material failure by Executive to comply with the policies or directives of the Board of Directors; (D) any illegal or dishonest
action that is materially detrimental to the Company; or (E) Executives failure to faithfully carry out the duties of Executives position, provided that Executive shall be given a period of thirty (30) days after receipt of written
notice of such failure during which to correct such failure; and (F) Executives violation of the Companys policies regarding harassment or unlawful discrimination.
| | ----- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



(c) Obligations upon Certain Terminations. Upon
voluntary termination of this Agreement, or termination of Executives employment by the Company for Cause (as defined above) or upon Executives death or disability, or termination by Executive for other than Good Reason (as defined
below), the Company shall have no further obligations hereunder other than the payment of all compensation and other benefits payable to Executive through the date of such termination.



(d) Severance. In the event of termination of Executives employment (i) by the Company for
reasons other than Cause or Executives death or disability, or (ii) by Executive for Good Reason, and provided Executive executes and delivers a Release and Settlement Agreement in a form acceptable to the Company, Executive shall receive a
severance benefit in an amount equal to one (1) years base salary plus the average annual bonus awarded Executive over the previous two (2) years (the Severance Benefit). The Severance Benefit will be payable in accordance with the
Companys normal payroll policies over a period of twelve (12) months from the date of termination. Executive shall also continue to be entitled to receive all Company benefits to which Executive was entitled as of the date of termination,
subject to the terms of all applicable benefit plans and to the extent such benefits can be provided to a non-employee (or to the extent such benefits cannot be provided to non-employees, then the cash equivalent thereof), at the same average level
and on the same terms and conditions which applied immediately prior to the date of Executives termination, for the shorter of (i) one year following the date of such termination or (ii) until Executive obtains comparable coverage from another
employer (the Continuing Benefits). At any time during the



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severance period, the Company may elect to pay a lump sum amount to Executive which represents the
reasonable value of the Severance Benefit and/or the Continuing Benefits reduced to their present value in lieu of continuing payment of such benefits.



(e) Good Reason. For purposes of this Agreement, Good Reason shall mean, the occurrence, without the consent of
Executive, of any of the following events, unless, in the case of (i), (ii) and (iii) below, such event is corrected within thirty (30) days after written notification by Executive to the Company of the same: (i) the office from which Executive
performs Executives principal duties is moved more that 50 miles from the current location of the Companys offices in Chapel Hill, North Carolina; (ii) Executives duties and responsibilities are substantially reduced or diminished;
(iii) the Company materially breaches its obligations under this Agreement; or (iv) a Change of Control (as defined below) occurs and Executive notifies the Company in writing within sixty (60) days of the consummation of such Change of Control that
Executive intends to terminate Executives employment as a result of the Change of Control, in which event such termination shall be effective not less than sixty (60) days after the date of such written notice.



(f) Tax Gross-Up for Parachute Payments.



(A) If at any time or from time to time it shall be
determined that any payment to Executive pursuant to this Agreement or any other payment or benefit hereunder or under any other plan or agreement or otherwise (Potential Parachute Payment) would constitute an excess parachute
payment within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the Code), and thus would be subject to the excise tax imposed by Section 4999 of the Code, or any similar tax payable under any United
States federal, state, local, foreign or other law (Excise Tax), then Executive shall receive and the Company shall pay or cause to be paid a Tax Gross-Up Payment with respect to all Taxes as defined below. The Tax Gross-Up Payment is
intended to compensate Executive for all such excise taxes and federal, state, local, foreign or other income, employment or excise taxes or other taxes (Taxes) payable by Executive with respect to the Tax Gross-Up Payment and shall be
in an amount such that after payment of Taxes on such amount there remains a balance sufficient to pay the taxes being reimbursed. For purposes of determining the amount of the Tax Gross-Up Payment, Executive shall be deemed to pay federal income
tax and employment taxes at the highest marginal rate of federal income and employment taxation in the calendar year in which the Tax Gross-Up Payment is to be made and state and local income taxes at the highest marginal rate of taxation in the
state and locality of Executives residence (or, if greater, the state and locality in which Executive is required to file a nonresident income tax return with respect to the Potential Parachute Payment), net of the maximum reduction in federal
income taxes that may be obtained from the deduction of such state and local taxes.



(B) The determinations to be made under this Section 5(f) shall be made by the Companys independent public accountants (the
Accounting Firm), which firm shall provide its determinations and any supporting calculations both to the



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Company and to Executive. Any such determination by the Accounting Firm shall be binding upon the Company
and Executive. All fees and expenses of the Accounting Firm in performing the determinations referred to in this Section 5(f) shall be borne solely by the Company, and the Company shall indemnify and hold harmless the Accounting Firm of and from any
and all claims, damages and expenses resulting therefrom, except for claims, damages or expenses resulting from the gross negligence or willful misconduct of the Accounting Firm.



(g) Disability. For purposes of this Agreement, Executive shall be considered permanently disabled
when a qualified medical doctor mutually acceptable to the Company and Executive or Executives personal representative shall have certified in writing that: (i) Executive is unable because of medically determinable physical or mental
disability to perform substantially all of Executives duties for more than one hundred eighty (180) calendar days measured from the last full day of work; or (ii) by reason of mental or physical disability, it is unlikely that Executive will
be able, within one hundred eighty (180) calendar days, to resume substantially all business duties and responsibilities in which Executive was previously engaged and otherwise discharge Executives duties under this Agreement.



(h) Change of Control. For purposes of this
Agreement, a Change of Control shall be deemed to have occurred:



(i) If any person (as such term is used in sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the Exchange Act)) (other than the Company or any trustee or fiduciary holding
securities under an employee benefit plan of the Company) becomes a beneficial owner (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 50% or more of the voting power of the then
outstanding securities of the Company; provided that a Change of Control shall not be deemed to occur as a result of a transaction in which the Company becomes a subsidiary of another corporation and in which the stockholders of the Company,
immediately prior to the transaction, will beneficially own, immediately after the transaction, shares entitling such stockholders to more than 50% of all votes to which all stockholders of the parent corporation would be entitled in the election of
directors (without consideration of the rights of any class of stock to elect directors by a separate class vote); or



(ii) Upon the consummation of (A) a merger or consolidation of the Company with another corporation where the stockholders of the Company,
immediately prior to the merger or consolidation, will not beneficially own, immediately after the merger or consolidation, shares entitling such stockholders to more than 50% of all votes to which all stockholders of the surviving corporation would
be entitled in the election of directors (without consideration of the rights of any class of stock to elect directors by a separate class vote), (B) a sale or other disposition of all or substantially all of the assets of the Company, or (C) a
liquidation or dissolution of the Company.



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6. NON-DISCLOSURE, INVENTIONS AND NON COMPETITION. As a condition to Executives employment by the
Company and simultaneously with the execution of this Agreement, Executive shall execute and agrees to be bound by the terms of the Companys standard non-disclosure, inventions and non-competition agreement in the form attached hereto as
Exhibit B and incorporated herein by reference.



7.
NOTICES. Any notice required to be given shall be in writing personally delivered by certified mail or registered mail or by facsimile (receipt confirmed) to the address last shown in the Companys records.



8. SEVERABILITY. The provisions of this Agreement shall be deemed severable,
and the invalidity or unenforceability of any provision (or part thereof) of this Agreement shall in no way affect the validity or enforceability of any other provision (or remaining part thereof).



9. GOVERNING LAW. This Agreement shall be governed by and construed according
to the laws of the State of North Carolina, without reference to the choice of law provisions of such laws.



10. ENTIRE AGREEMENT. This Agreement contains the entire agreement of the parties relating to the subject matter hereof, and the parties hereto have made
no agreements, representations, or warranties relating to the subject matter of this Agreement which are not set forth herein. In particular, without limiting the foregoing, this Agreement supersedes in its entirety that certain offer letter from
the Company to Executive dated July [21], 2004 and that certain Consulting Agreement by and between the Company and Executive dated July 26, 2004. No modification of this Agreement shall be valid unless made in writing and signed by the parties
hereto.



11. BENEFIT. This Agreement shall be binding upon and
inure to the benefit of both parties and their respective heirs, representatives, successors and assigns, including any corporation or other entity with which or into which the Company may be merged or which may succeed to its assets or business;
provided, however, that the obligations of Executive are personal and shall not be assigned by Executive.



12. EXECUTIVE REPRESENTATIONS.



(a) Executive represents that his performance of this Agreement and as an employee of the Company does not and will not breach any
non-competition or other agreement to keep in confidence proprietary information acquired by Executive in confidence or in trust prior to Executives employment by the Company. Executive represents that he has not entered into, and agrees not
to enter into, any agreement that conflicts with or violates this Agreement or would prevent or interfere with the companys employment of Executive on the terms set forth herein.



(b) Executive represents that he has not brought and shall not bring with Executive to the Company, or use
in the performance of Executives responsibilities for the



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Company, any materials or documents of a former employer which are not generally available to the public
or which did not belong to Executive prior to his employment with the Company, unless Executive has obtained written authorization from the former employer or other owner for their possession and use and provided the Company with a copy thereof.



13. INJUNCTIVE RELIEF. Executive understands and agrees that
the Company will suffer irreparable harm in the event that Executive breaches any of Executives obligations under this Agreement and that monetary damages will be inadequate to compensate the Company for such breach. Accordingly, Executive
agrees that, in the event of a breach or threatened breach by Executive of any of the provisions of this Agreement, the Company, in addition to and not in limitation of any other rights, remedies, or damages available to the Company at law or in
equity, shall be entitled to a permanent injunction in order to prevent or to restrain any such breach by Executive, or by Executives partners, agents, representatives, servants, employers, employees and/or any and all persons directly or
indirectly acting for or with Executive; provided such injunction shall not affect Executives ownership rights in the Company or compensation earned or due Executive.



[Signature page follows]



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IN WITNESS WHEREOF, the parties hereto have executed this Executive Employment Agreement and affixed
their seals as of the day and year first above written.



EMPLOYER:POZEN INC.By:

/s/ John R. PlachetkaName:

John R. Plachetka, Pharm.D.Title:

Chairman, President and CEOEMPLOYEE:/s/ William L. HodgesWilliam L. Hodges




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EXHIBIT A



Senior Vice President, Finance and Administration and Chief Financial Officer

Responsibility and Tasks List



Reporting to the President, the Senior Vice President, Finance and Administration and Chief Financial Officer (CFO) will assist in developing the strategic direction of the Company and have the skills
necessary to lead in the growth of the Company. The CFO will be responsible for all financial activities and relationships of the Company. Importantly, the CFO will be expected to lead anticipated financing and corporate development transactions
from conceptualization through to implementation and integration. The CFO will assure that the Company maintains the strong financial infrastructure required to support continued rapid growth. This executive will be widely viewed as a key member of
the management team with responsibility for influencing the thinking and decisions behind the Companys overall strategies, plans, and operations. Specific responsibilities will include, among others, the management of:



| | Finance  the evaluation, analysis and execution of all capital raising and all other finance related projects.
|- | ---------------------------------------------------------------------------------------------------------------



| | Corporate Development  manage the analysis, execution and integration of mergers, acquisitions, and contribute significantly to the analysis, execution and integration of
business partnerships, licensing agreements, etc.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | Investor Relations - working closely with the CEO and additional senior management as appropriate, leading the effort to interface with the investment community, specifically in
working with institutional investors, research analysts, investment bankers and corporate partners.
|- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | Accounting  management of individuals responsible for the implementation and management of the accounting structure, methods, systems, operating procedures and FASB and SEC
requirements.
|- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | Planning/Forecasting  management of corporate-wide financial planning, procedures, measures, budgeting and forecasting, project specific financial analysis and general risk
analysis.
|- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | Reporting and Analysis  responsible for the timely and accurate reporting and analysis, both written and oral, of financial and associated business information to internal,
external, and regulatory constituencies.
|- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



The CFO will be a
partner with the rest of the senior management team and get involved in a variety of strategic and business challenges that go beyond the financial function. Skills in oral and written communication, strategic thinking, combined with a personal
sense of flexibility and humor, will lead to a successful integration of the new CFO into the Companys culture. Additionally, the CFO will be expected to:



| |  | Supervise corporate communications and all aspects of investor relations.
| | - | -------------------------------------------------------------------------



| |  | Possess an entrepreneurial, can do attitude.
| | - | --------------------------------------------



| |  | Possess excellent communication skills and has experience delivering company presentations at investment conferences.
| | - | ---------------------------------------------------------------------------------------------------------------------



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| |  | Be a team player with a pleasant, engaging personality.
| | - | -------------------------------------------------------



| |  | Possess excellent managerial skills.
| | - | ------------------------------------



| |  | Demonstrate a track record of unquestioned integrity and honesty.
| | - | -----------------------------------------------------------------



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EXHIBIT B



NON-DISCLOSURE, INVENTION AND NON-COMPETITION AGREEMENT



THIS NON-DISCLOSURE, INVENTION AND NON-COMPETITION AGREEMENT (the Agreement) is effective for all purposes and in all respects, by and
between POZEN Inc., a Delaware corporation (hereinafter referred to as Employer), and 
(hereinafter referred to as Employee).



WHEREAS,
Employer is about to employ Employee in a position of trust and confidence to aid Employer in its business; and



WHEREAS, Employer desires to receive from Employee a covenant not to disclose certain information relating to Employers business and certain other
covenants; and



WHEREAS, as a material inducement to Employer
to employ Employee and to pay to Employee compensation for such services, Employee has agreed to such covenants; and



WHEREAS, Employer and Employee desire to set forth in writing the terms and conditions of their agreements and understandings.



NOW, THEREFORE, in consideration of the foregoing, of the mutual promises
herein contained, and of other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending legally to be bound, hereby agree as follows:



1. Disclosure of Information. Employee acknowledges that, in and as a
result of his employment by Employer, he will be making use of, acquiring and/or adding to confidential information of a special and unique nature and value, including, without limitation, Employers trade secrets, products, systems, programs,
procedures, manuals, guides (as periodically updated or supplemented), confidential reports and communications (including, without limitation, customer site information, technical information on the performance and reliability of Employers
products and the development or acquisition of future products or product enhancements by Employer) and lists of customers, as well as the nature and type of the services rendered by Employer and the fees paid by Employers customers. Employee
further acknowledges that any information and materials received by Employer from third parties in confidence (or subject to non-disclosure covenants) shall be deemed to be and shall be confidential information within the meaning of this Section 1.
As a material inducement to Employer to employ Employee and to pay to Employee compensation for such services to be rendered to Employer by Employee (it being understood and agreed by the parties hereto that such compensation shall also be paid and
received in consideration hereof), Employee covenants and agrees that he shall not, except with the prior written consent of the Board of Directors of Employer, at any time during or following the term of his employment with Employer, directly or
indirectly, divulge, reveal, report, publish, transfer or disclose, for any purpose whatsoever, any of such confidential information which has been obtained by or disclosed to him as a result of his employment with Employer, including, without
limitation, any Proprietary Information, as



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defined in Section 2 hereof; Employee agrees further that upon termination of his employment with Employer for any
reason, he shall sign the Employee Termination Statement, a form of which is attached hereto. The aforementioned obligation of confidentiality and non-disclosure shall not apply when:



(a) Public Domain. The information disclosed to Employee was in the public domain at the time of disclosure, or at
any time after disclosure has become a part of the public domain by publication or otherwise through sources other than Employee, directly or indirectly, and without fault on the part of Employee in failing to keep such information confidential; or



(b) Requirement of Law or Order. Disclosure is required
by law or court order, provided Employee gives Employer prior written notice of any such disclosure; or



(c) Agreement. Disclosure is made with the prior written agreement of the Board of Directors of Employer; or



(d) Prior Information. The information is encompassed by the ideas and
inventions listed on Schedule A hereto or was in Employees possession at the time of disclosure, as shown by written records in existence prior to such time, and such information has not been transferred to Employer, and was not
acquired, directly or indirectly, from the Employer; or



(e)
Third Party Disclosure. The information is lawfully disclosed to Employee after the termination of his employment by a third party who is under no obligation of confidentiality to Employer with respect to such information; or



(f) Independently Developed. Such information is independently
developed by Employee subsequent to the termination of his active participation in the business of Employer, as demonstrated by written records of Employee which are contemporaneously maintained.



2. Definition of Proprietary Information. For purposes of this
Agreement, the term Proprietary Information shall mean all of the following materials and information (whether or not reduced to writing and whether or not patentable or protectable by copyright) which Employee receives, receives access
to, conceives of or develops, in whole or in part, as a direct or indirect result of his employment with Employer, in the course of his employment with Employer (in any capacity, whether executive, managerial, planning, technical, sales, research,
development, manufacturing, engineering or otherwise) or through the use of any of Employers facilities or resources:



(i) Manufactured products, assembled or unassembled, and any related goods or systems and any and all future products, software or systems developed or
derived therefrom;



(ii) With respect to the items described
in Section 2(i) above, all hardware and software relating to design or manufacture; all source and object codes to such hardware and software; all specifications, design concepts, documents and manuals; all security systems relating to the product
or procedures, including, without limitation, software security systems;



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(iii) Trade secrets, production processes, marketing techniques, mailing lists, purchasing information,
price lists, pricing policies, quoting procedures, financial information, customer and prospect names and requirements, customer data, customer site information and other materials or information relating to the manner in which Employer does
business;



(iv) Discoveries, concepts and ideas, whether or
not patentable or protectable by copyright, including, without limitation, the nature and results of research and development activities, technical information on product or program performance and reliability, processes, formulas, techniques,
know-how, source codes, object codes, designs, drawings and specifications;



(v) Any other material or information related to the business or activities of Employer which is not generally known to others engaged in similar businesses or activities;



(vi) Any other material or information that has been created, discovered or
developed, or otherwise becomes known to Employer which has commercial value in the business in which Employer is engaged; and



(vii) All ideas which are derived from or relate to Employees access to or knowledge of any of the above-enumerated materials and information.



Failure to mark any of the Proprietary Information as
confidential shall not affect its status as part of the Proprietary Information under the terms of this Agreement.



3. Ownership of Information.



(i) Employee hereby assigns to Employer all of Employees right, title and interest in any idea (whether or not patentable or protectable by
copyright), product, invention, discovery, computer software program or other computer-related equipment or technology, conceived or developed in whole or in part, or in which Employee may have aided in its development, while employed by Employer,
including, without limitation, any Proprietary Information. If any one or more of the aforementioned are deemed in any way to fall within the definition of work made for hire, as such term is defined in 17 U.S.C. § 101, such work
shall be considered work made for hire, the copyright of which shall be owned solely, completely and exclusively by Employer. If any of the aforementioned are considered to be work not included in the categories of work covered by the
work made for hire definition contained in 17 U.S.C. § 101, such work shall be owned solely by, or assigned or transferred completely and exclusively to, Employer. Employee agrees to execute any instruments and to do all other
things reasonably requested by Employer (both during and after Employees employment with Employer) in order to more fully vest in Employer all ownership rights in those items thereby transferred by Employee to Employer. Employee further agrees
to disclose immediately to



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Employer all Proprietary Information conceived of or developed in whole or in part by him during the term of his
employment with Employer and to assign to Employer any right, title or interest he may have in such Proprietary Information.



(ii) Employee hereby represents and warrants that Employee has fully disclosed to Employer on Schedule A hereto any idea, invention, product,
improvement, computer software program or other equipment or technology related to therapeutic pharmaceuticals (an Invention) not covered in Section 3(i) above which, prior to his employment with Employer, Employee conceived of or
developed, wholly or in part, and in which Employee has any right, title or proprietary interest and which directly relate to Employers business, but which has not been published or filed with the United States Patent or Copyright Offices or
assigned or transferred to Employer. If there is no such list of Schedule A, Employee represents that Employee has made no such Inventions at the time of signing this Agreement or Employee hereby assigns such Inventions to Employer.



(iii) Notwithstanding anything in this Agreement to the
contrary, the obligation of Employee to assign or offer to assign his rights in an Invention to Employer shall not extend or apply to an Invention that Employee developed entirely on his own time without using Employers equipment, supplies,
facility or trade secret information unless such Invention (a) relates to Employers business or actual or demonstrably anticipated research or development, or (b) results from any work performed by Employee for Employer. Employee shall bear
the burden of proof in establishing that his Invention qualifies for exclusion under this Section 3(iii). With respect to Section 3(iii), it is agreed and acknowledged that during Employees employment, Employer may enter other lines of
business, which are related or unrelated to its current lines of business, in which case this Agreement would be expanded to cover such new lines of business.



4. Injunctive Relief. Employee understands and agrees that Employer will suffer irreparable harm in the event that Employee breaches any of his
obligations under this Agreement and that monetary damages will be inadequate to compensate Employer for such breach. Accordingly, Employee agrees that, in the event of a breach or threatened breach by Employee of any of the provisions of this
Agreement, Employer, in addition to and not in limitation of any other rights, remedies or damages available to Employer at law or in equity, shall be entitled to a permanent injunction in order to prevent or to restrain any such breach by Employee,
or any of employees partners, agents, representatives, servants, employers, employees and/or any and all persons directly or indirectly acting for or with him.



5. Records. All notes, data, tapes, reference materials, sketches, drawings, memoranda, models and records in any way
relating to any of the information referred to in Sections 1, 2 and 3 hereof (including, without limitation, any Proprietary Information) or to Employers business shall belong exclusively to Employer, and Employee agrees to turn over to
Employer all such materials and all copies of such materials in his possession or then under his control at the request of Employer or, in the absence of such a request, upon the termination of Employees employment with Employer.



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6. Accounting for Profits. Employee covenants and agrees that, if he shall violate any of his
covenants or agreements under this Agreement, Employer shall be entitled to an accounting and repayment of all profits, compensation, commissions, remunerations or benefits which Employee directly or indirectly has realized and/or may realize as a
result of, growing out of or in connection with any such violation; such remedy shall be in addition to and not in limitation of any injunctive relief or other rights or remedies to which Employer is or may be entitled at law, in equity or under
this Agreement.



7. Covenant Not to Compete. It is
recognized and understood by the parties hereto that Employee, through Employees association with Employer as an employee, shall acquire a considerable amount of knowledge and goodwill with respect to the business of Employer, which knowledge
and goodwill are extremely valuable to Employer and which would be extremely detrimental to Employer if used by Employee to compete with Employer. It is, therefore, understood and agreed by the parties hereto that, because of the nature of the
business of Employer, it is necessary to afford fair protection to Employer from such competition by Employee. Consequently, as a material inducement to employ Employee in the aforementioned positions, Employee covenants and agrees to the following:



(a) Except as otherwise approved in writing by Employer,
Employee agrees:



(i) that Employee will not, directly or
indirectly, with or through any family member or former director, officer or employee of Employer, or acting alone or as a member of a partnership or as an officer, holder of or investor in as much as 5% of any security of any class, director,
employee, consultant or representative of any corporation or other business entity:



(1) at any time while engaged as an employee of Employer and for a period of two (2) years following termination as an employee, interfere with, or seek to interfere with, the relationship between Employer or any
affiliate of Employer and the following: (a) any of the employees of such entities; (b) any of the customers of such entities then existing or existing at any time within three (3) years prior to termination of Employees employment by
Employer; or (c) any of the suppliers of such entities then existing or existing at any time within three (3) years prior to termination of Employees employment by Employer.



(b) The parties hereto agree that in the event that either the length of time or the geographic area set forth in paragraph
(a) is deemed too restrictive in any court proceeding, that the court may reduce such restrictions to those which it deems reasonable under the circumstances.



(c) Employee agrees and acknowledges that Employer does not have any adequate remedy at law for the breach or threatened breach by him of this covenant
and agrees that Employer may in addition to the other remedies which may be available to it under this Agreement, file a suit in equity to enjoin Employee from such breach or threatened breach.



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8. Reasonableness of Restrictions.



(a) Employee has carefully read and considered the provisions of Sections 1
through 7 hereof and, having done so, agrees that the restrictions set forth therein are fair and reasonable and are reasonably required for the protection of the interests of Employer, its officers, directors, stockholders and employees.



(b) In the event that, notwithstanding the foregoing, any part
of the covenants set forth in Sections 1 through 7 hereof shall be held to be invalid and unenforceable, the court so deciding may reduce or limit the terms of such provision to allow such provision to be enforced.



9. Burden and Benefit. This Agreement shall be binding upon, and shall
inure to the benefit of, Employer and Employee, and their respective heirs, personal and legal representatives, and, in the case of Employer, its successors and assigns.



10. Governing Law. In view of the fact that the principal office of Employer is located in the State of North
Carolina, it is understood and agreed that the construction and interpretation of this Agreement shall at all times and in all respects be governed by the laws of the State of North Carolina.



11. Severability. The provisions of this Agreement shall be deemed
severable, and the invalidity or unenforceability of any one or more of the provisions hereof shall not affect the validity or enforceability of the other provisions hereof.



12. Employer. As used herein, the term Employer shall also include any corporation which is at any time
the parent or a subsidiary of Employer, or any corporation or entity which is an affiliate of Employer by virtue of common (although not identical) ownership, and for which Employee is providing services in any form during his employment with
Employer or any such other corporation or entity.



13.
Notices. Any notice required to be given hereunder shall be sufficient if in writing, and sent by certified or registered mail, return receipt requested, first-class postage prepaid, in the case of Employee, to his address as shown on
Employers records, and in the case of Employer, to its principal office in the State of North Carolina.



14. Entire Agreement. This Agreement contains the entire agreement and understandings by and between Employer and Employee with respect to the
covenants herein described, and no representations, promises, agreements or understandings, written or oral, not herein contained shall be of any force or effect. Nothing contained in this Agreement shall be deemed or construed to constitute an
agreement by Employer to employ or continue to employ Employee. No change or modification hereof shall be valid or binding unless the same is in writing and signed by the parties hereto. No waiver of any provision of this Agreement shall be valid
unless the same is in writing and signed by the party against whom such waiver is sought to be enforced; moreover, no valid waiver of any provision of this Agreement at any time shall be deemed a waiver of any other provision of this Agreement at
such time nor will it be deemed a valid waiver of such provision at any other time.



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15. Headings. The headings and other captions in this Agreement are for convenience and reference
only and shall not be used in interpreting, construing or enforcing any of the provisions of this Agreement.



16. Effective Date. This Agreement shall be effective as of , 2004.



IN WITNESS WHEREOF, Employer and Employee have duly executed
this Agreement as of the day and year first above written.



EMPLOYER:



|           |  |                                      
|---------- |  | -------------------------------------
|POZEN Inc.
|           | 
|By:        |  |                                      
|Name:      |  | John R. Plachetka, Pharm.D.          
|Title:     |  | President and Chief Executive Officer
|          
|EMPLOYEE: 
|           | 
|           |  |                                      
|           |  |                                      



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SCHEDULE A



Inventions, Ideas, Products, Etc. Not Covered in Section 3(i) of the Agreement



[Note: If Employee has no such items to disclose, write NONE on this line:
.]



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EMPLOYEE TERMINATION STATEMENT



1. I am cognizant of my legal obligations, as stated in that certain Non-Disclosure, Invention and Non-Competition
Agreement, dated , , which I signed at the commencement of my employment with respect to
confidential information of POZEN Inc. (the Company), and hereby specifically reaffirm all of the provisions stated therein.



2. I understand that my obligation not to use or disclose Company confidential information remains in effect after the termination of my employment with
the Company and that if, at any time in the future, I wish to utilize, disclose or publish any Company confidential information, or if I should be in doubt as to whether any such information may be confidential to the Company, I will, prior to such
use or disclosure, obtain the written consent of the Company to do so. I further understand that such consent may be refused where Company confidential information is involved.



3. I understand that, to the extent permitted by law, any idea, invention, discovery, computer software program or other
computer-related equipment or technology, conceived or developed by me in whole or in part, or in which I may have aided in its development during my employment with the Company, belongs exclusively to the Company. I hereby certify that I have made
full disclosure in writing to the Company or have discussed with my supervisor at the Company all of such ideas, inventions, discoveries, computer programs and computer-related equipment or technology. I further understand that I still have an
obligation subsequent to termination of my employment with the Company to execute such papers as the Company may reasonably request to more fully vest in the Company all ownership rights in the items referenced in this paragraph.



4. I hereby certify that all materials related directly or indirectly to my
employment with the Company and all copies thereof, have been returned to my supervisor at the Company. I further certify that no computer listings, programs, object codes, source codes, product development guides, flow-charts or other documents
owned by the Company or provided to or used by me in connection with my employment at the Company, whether in machine-readable form or otherwise, have been retained by me or given to any other third person or entity in anticipation of my employment
termination or for any other reason, and further certify that none of the aforementioned will be removed from the Companys premises by me.



ACCEPTED:



POZEN Inc.



|     |  |  |  |      |  | 
|---- |  |  |  | ---- |  | 
|By:  |  |  |  |      |  | 
|     |  | 
|     |  |  |  |     
|Date |  |  |  | Date



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