U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 close



Research
                Research Home
                            National Programs
                            Research Projects
                            Scientific Manuscripts
                            International Engagement
                            Scientific Software/Models
                            Databases and Datasets
                            Office of Scientific Quality Review
            Media
                News & Features
                            Multimedia
                            Briefing Room
                            Down on the Farm
                            Press Room
                            Science in Your Shopping Cart
                            Scientific Discoveries
                            Tellus
                            Under the Microscope
            About ARS
                About ARS Home
                            Staff Directory
                            Labs and Research Centers (Map)
                            Headquarter Offices
                            Organizational Chart
                            Employee Services (REE Employees Only)
                            Office of Outreach, Diversity, and Equal Opportunity
            Work With Us
                Work With Us Home
                            ARS Vacancies at USAJOBS
                            Careers at ARS Information
                            Scientific Collaborations
                            Extramural Agreements
                            1890 Faculty Research Sabbatical ProgramSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Research Publications at this Location





- ARS National Programs
- Search for a scientific manuscript
- Search for a research project
- ARS Software
- Programs and Projects
- Collaborations
- Subjects of Investigation
- Publications

Title:   Author  item
                                            YUN, CHEOL - NIH BETHESDA, MDitem
                                            Lillehoj, Hyunitem
                                            CHOI, KANG - KOREA
  Submitted to: Infection and Immunity
                                    Publication Type: Peer Reviewed Journal
                                    Publication Acceptance Date: 2/1/2000
                                    Publication  Date: N/A
                                    Citation: N/AInterpretive Summary: Coccidiosis is a major parasitic disease of poultry which costs a significant economic loss to the poultry industry worldwide.  Ability to develop vaccine for coccidiosis would significantly reduce production loss due to this parasite and enhances US economy.  In this study, ARS scientists studied intestinal lymphocyte response following coccidia  infection to understand the nature of protective host immune response to this parasite.  The results showed that coccidia infection induces changes in the percentages of thymus-derived lymphocytes in the intestine.  There was a significant increase of interferon-gamma production and CD4 cells at the time of parasite reduction indicating that these types of host immune responses are important in the elimination of coccidia parasites.  These results also indicate the importance of studying intestinal response to understand host immunity to coccidiosis.  This study provide information on nthe nature of host protective immunity to avian coccidiosis and will enhance possibility of developing immunological control strategy against this infection.
                                Technical Abstract: The role of intestinal lymphocytes and IFN-gamma production in protective immunity to Eimeria tenella infection was evaluated in two inbred strains of chickens (SC and TK) that display different patterns of  susceptibility to coccidiosis.  Oral inoculation of either strain with E. tenella lead to parasite invasion of the intestinal cecum and cecal tonsils. Greater fecal  oocyst shedding was seen in TK chickens.  Flow cytometric analyses of ceca tonsil lymphocytes demonstrated greater numbers of CD4+ and TCR1+ cells in SC chickens and elevated numbers of CD8+ and TCR2+ cells in TK chickens following primary infection.  IFN-gamma  mRNA expression was significantly increased in cecal tonsil and intraepithelial lymphocytes at days 6 and 8 post-primary infection respectively in SC compared to TK chickens.  While no differences were noted between cecal tonsil lymphocytes of the two strains following secondary infection, TK chickens showed elevated  IFN-gamma transcript levels in intestinal intraepithelial lymphocytes at this time.  Selective depletion of CD4+, but not CD8+, cecal tonsil lymphocytes in SC chickens resulted in a reduced IFN-gamma  mRNA expression indicating that CD4+ cells are the primary source of this cytokine. Collectively, these results indicate that local lymphocyte responses and production of IFN-gamma are influenced by host genetic factors.


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov