EX-4.1




 Exhibit 4.1 

In accordance with Instruction 2 to Item 601 of Regulation S-K, below is a schedule setting forth details in which the
omitted executed warrants differ from the form of warrant that follows: 
  

					
	Warrantholder	  	Number of
Shares	  	Loan Name
	 Horizon Technology Finance Corporation
	  	103,092	  	A
	 Horizon Technology Finance Corporation
	  	154,639	  	B
	 Horizon Technology Finance Corporation
	  	61,855	  	C
	 Horizon Technology Finance Corporation
	  	61,855	  	D
	 Horizon Technology Finance Corporation
	  	41,237	  	E
	 Horizon Technology Finance Corporation
	  	41,237	  	F

 THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”) OR ANY
STATE SECURITIES LAWS. NO SALE OR DISPOSITION MAY BE EFFECTED WITHOUT (i) EFFECTIVE REGISTRATION STATEMENTS RELATED THERETO, (ii) AN OPINION OF COUNSEL OR OTHER EVIDENCE, REASONABLY SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATIONS ARE
NOT REQUIRED, (iii) RECEIPT OF NO-ACTION LETTERS FROM THE APPROPRIATE GOVERNMENTAL AUTHORITIES, OR (iv) OTHERWISE COMPLYING WITH THE PROVISIONS OF SECTION 7 OF THIS WARRANT. 

EVELO BIOSCIENCES, INC. 

WARRANT TO PURCHASE SHARES 
 OF
COMMON STOCK 
 (Loan [A/B/C/D/E/F]) 

THIS CERTIFIES THAT, for value received, HORIZON TECHNOLOGY FINANCE CORPORATION and its assignees are entitled to subscribe for and purchase [
● ] shares of the fully paid and nonassessable common stock, par value $0.001 per share (the “Common Stock”) of EVELO BIOSCIENCES, INC., a Delaware corporation (the “Company”), at the price of $1.94 per
share (such price and such other price as shall result, from time to time, from the adjustments specified in Section 4 hereof is herein referred to as the “Warrant Price”), subject to the provisions and
upon the terms and conditions hereinafter set forth. As used herein, (a) the term “Shares” shall mean shares of the Company’s Common Stock, as adjusted pursuant to Section 4 hereof, (b) the term
“Date of Grant” shall mean December 15, 2022, (c) the term “Other Warrants” shall mean any other warrants issued by the Company in connection with the transaction with respect to which this Warrant was issued,
and any warrant issued upon transfer or partial exercise of or in lieu of this Warrant. The term “Warrant” as used herein shall be deemed to include Other Warrants unless the context clearly requires otherwise. 











 1. Term. The purchase right represented by this Warrant is exercisable, in whole or
in part, at any time and from time to time from the Date of Grant through ten (10) years after the Date of Grant (the “Term”). 

2. Method of Exercise; Payment; Issuance of New Warrant. Subject to Section 1 hereof, the purchase right
represented by this Warrant may be exercised by the holder hereof, in whole or in part and from time to time, at the election of the holder hereof, by (a) the surrender of this Warrant (with the notice of exercise substantially in the form
attached hereto as Exhibit A-1 duly completed and executed) at the principal office of the Company and by the payment to the Company, by certified or bank check, or by wire transfer
to an account designated by the Company (a “Wire Transfer”) of an amount equal to the then applicable Warrant Price multiplied by the number of Shares then being purchased; (b) if in connection with the sale of Shares in an
underwritten public offering of Common Stock under the Securities Act (a “Public Offering”), the surrender of this Warrant (with the notice of exercise form attached hereto as
Exhibit A-2 duly completed and executed) at the principal office of the Company together with notice of arrangements reasonably satisfactory to the Company for payment to the Company
either by certified or bank check or by Wire Transfer from the proceeds of the sale of shares to be sold by the holder in such public offering of an amount equal to the then applicable Warrant Price per share multiplied by the number of Shares then
being purchased; or (c) exercise of the “net issuance” right provided for in Section 10(b) hereof. The person or persons in whose name(s) any certificate(s) representing the Shares shall be issuable upon
exercise of this Warrant shall be deemed to have become the holder(s) of record of, and shall be treated for all purposes as the record holder(s) of, the Shares represented thereby (and such Shares shall be deemed to have been issued) immediately
prior to the close of business on the date or dates upon which this Warrant is exercised. In the event of any exercise of the rights represented by this Warrant, certificates or, if such Shares are not certificated, evidence the Shares have been
recorded by book entry in the Company’s book and records for the Shares so purchased shall be delivered to the holder hereof as soon as practicable and in any event within fifteen (15) business days after such exercise and, unless this
Warrant has been fully exercised or expired, a new Warrant representing the portion of the Shares, if any, with respect to which this Warrant shall not then have been exercised shall also be issued to the holder hereof as soon as practicable and in
any event within such fifteen (15) business day period; provided, however, at such time as all Shares being exercised are eligible for resale by the holder hereof pursuant to Rule 144 (as defined below) under the Securities Act or
another similar exemption under the Securities Act is available for the sale of all of such holder’s shares without limitation, during a three (3)-month period without registration (and without the requirement for the Company to be in
compliance with the current public information required under subsection (c)(1) of Rule 144), the Company, subject to the terms and conditions set forth in Section 7(b), shall instruct its transfer agent to deliver the certificate representing
Shares issued upon exercise of this Warrant to a broker or other person (as directed by the holder exercising this Warrant) within the time period required to settle any trade made by the holder after exercise of this Warrant. 

3. Stock Fully Paid; Reservation of Shares. All Shares that may be issued upon the exercise of the rights represented by this Warrant
will, upon issuance pursuant to the terms and conditions herein, be fully paid and nonassessable, and free from all preemptive rights and taxes, liens and charges with respect to the issue thereof. During the period within which the rights
represented by this Warrant may be exercised, the Company will at all times have authorized, and reserved for the purpose of the issue upon exercise of the purchase rights evidenced by this Warrant, a sufficient number of Shares to provide for the
exercise of the rights represented by this Warrant. 

  
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 4. Adjustment of Warrant Price and Number of Shares. The number and kind of
securities purchasable upon the exercise of this Warrant and the Warrant Price shall be subject to adjustment from time to time upon the occurrence of certain events, as follows: 

(a) Reclassification or Merger. (i) In case of any reclassification or change of securities of the class issuable upon exercise of
this Warrant (other than a change in par value, or from par value to no par value, or from no par value to par value, or as a result of a subdivision or combination), (ii) in case of any merger of the Company with or into another entity (other than
a merger with another entity in which the Company is the acquiring and the surviving entity and which does not result in any reclassification or change of outstanding securities issuable upon exercise of this Warrant), or (iii) in case of any
sale of all or substantially all of the assets of the Company, the Company, or such successor or purchasing entity, as the case may be, shall duly execute and deliver to the holder of this Warrant a new Warrant (in form and substance satisfactory to
the holder of this Warrant), so that the holder of this Warrant shall have the right to receive upon exercise of such new Warrant, at a total purchase price not to exceed that payable upon the exercise of the unexercised portion of this Warrant, and
in lieu of the Shares theretofore issuable upon exercise of this Warrant, (A) the kind and amount of shares of stock, other securities, money and property receivable upon such reclassification, change, merger or sale by a holder of the number
of Shares then purchasable under this Warrant, or (B) in the case of such a merger or sale in which the consideration paid consists all or in part of assets other than securities of the successor or purchasing entity, at the option of the
holder of this Warrant, the securities of the successor or purchasing entity having a value at the time of the transaction equivalent to the value of the Common Stock purchasable upon exercise of this Warrant at the time of the transaction. Any new
Warrant shall provide for adjustments that shall be as nearly equivalent as may be practicable to the adjustments provided for in this Section 4. The provisions of this Section 4(a) shall similarly
apply to successive reclassifications, changes, mergers and sales. 
 (b) Subdivision or Combination of Shares. If the Company at any
time while this Warrant remains outstanding and unexpired shall subdivide or combine its outstanding Shares, the Warrant Price shall be proportionately decreased and the number of Shares issuable hereunder shall be proportionately increased in the
case of a subdivision and the Warrant Price shall be proportionately increased and the number of Shares issuable hereunder shall be proportionately decreased in the case of a combination. 

(c) Stock Dividends and Other Distributions. If the Company at any time while this Warrant is outstanding and unexpired shall
(i) pay a dividend with respect to its Common Stock payable in Common Stock, then the Warrant Price shall be adjusted, from and after the date of determination of shareholders entitled to receive such dividend or distribution, to that price
determined by multiplying the Warrant Price in effect immediately prior to such date of determination by a fraction (A) the numerator of which shall be the total number of shares of Common Stock outstanding immediately prior to such dividend or
distribution, and (B) the denominator of which shall be the total number of shares of Common Stock outstanding immediately after such dividend or distribution; or (ii) make any other distribution with respect to Common Stock (except any
distribution specifically provided for in Sections 4(a) and 4(b)), then, in each such case, provision shall be made by the Company such that the holder of this Warrant shall receive upon exercise of this Warrant a proportionate share
of any such dividend or distribution as though it were the holder of the Shares as of the record date fixed for the determination of the shareholders of the Company entitled to receive such dividend or distribution. 

  
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 (d) Adjustment of Number of Shares. Upon each adjustment in the Warrant Price, the
number of Shares purchasable hereunder shall be adjusted, to the nearest whole share, to the product obtained by multiplying the number of Shares purchasable immediately prior to such adjustment in the Warrant Price by a fraction, the numerator of
which shall be the Warrant Price immediately prior to such adjustment and the denominator of which shall be the Warrant Price immediately thereafter. 

5. Notice of Adjustments. Whenever the Warrant Price or the number of Shares purchasable hereunder shall be adjusted pursuant to
Section 4 hereof, the Company shall make a certificate signed by its chief financial officer setting forth, in reasonable detail, the event requiring the adjustment, the amount of the adjustment, the method by which such
adjustment was calculated, and the Warrant Price and the number of Shares purchasable hereunder after giving effect to such adjustment, and shall cause copies of such certificate to be mailed (without regard to Section 13
hereof, by first class mail, postage prepaid) to the holder of this Warrant. 
 6. Fractional Shares. No fractional shares of Common
Stock will be issued in connection with any exercise hereunder, but in lieu of such fractional shares the Company shall make a cash payment therefor based on the fair market value of the Common Stock on the date of exercise as reasonably determined
in good faith by the Company’s Board of Directors. 
 7. Compliance with Securities Act; Disposition of Warrant or Shares. 

(a) Compliance with Securities Act. The holder of this Warrant, by acceptance hereof, agrees that this Warrant, and the Shares to be
issued upon exercise hereof are being acquired for investment and that such holder will not offer, sell or otherwise dispose of this Warrant, or any Shares except under circumstances which will not result in a violation of the Securities Act or any
other applicable federal or state securities laws. Upon exercise of this Warrant, unless the Shares being acquired are registered under the Securities Act and any applicable state securities laws or an exemption from such registration is available,
the holder hereof shall confirm in writing that the Shares so purchased are being acquired for investment and not with a view toward distribution or resale in violation of the Securities Act and shall confirm such other matters related thereto as
may be reasonably requested by the Company. This Warrant and all Shares issued upon exercise of this Warrant (unless registered under the Securities Act and any applicable state securities laws) shall be stamped or imprinted with a legend in
substantially the following form: 
 “THE SECURITIES EVIDENCED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR
ANY STATE SECURITIES LAWS. NO SALE OR DISPOSITION MAY BE EFFECTED WITHOUT (i) EFFECTIVE REGISTRATION STATEMENTS RELATED THERETO, (ii) AN OPINION OF COUNSEL OR OTHER EVIDENCE, REASONABLY SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATIONS
ARE NOT REQUIRED, (iii) RECEIPT OF NO-ACTION LETTERS FROM THE APPROPRIATE GOVERNMENTAL AUTHORITIES, OR (iv) OTHERWISE COMPLYING WITH THE PROVISIONS OF SECTION 7 OF THE WARRANT UNDER WHICH THESE
SECURITIES WERE ISSUED, DIRECTLY OR INDIRECTLY.” 

  
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 Said legend shall be removed by the Company, upon the request of a holder and upon
satisfaction of any conditions set forth in Section 7(b), at such time as the restrictions on the transfer of the applicable security shall have terminated. In addition, in connection with the issuance of this Warrant, the holder specifically
represents to the Company by acceptance of this Warrant as follows: 
 i. The holder is aware of the Company’s business affairs and
financial condition, and has acquired information about the Company sufficient to reach an informed and knowledgeable decision to acquire this Warrant. The holder is acquiring this Warrant for its own account for investment purposes only and not
with a view to, or for the resale in connection with, any “distribution” thereof in violation of the Securities Act. 
 ii. The
holder understands that this Warrant has not been registered under the Securities Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the holder’s investment intent as
expressed herein. 
 iii. The holder further understands that this Warrant must be held indefinitely unless subsequently registered under
the Securities Act and qualified under any applicable state securities laws, or unless exemptions from registration and qualification are otherwise available. The holder is aware of the provisions of Rule 144, promulgated under the Securities Act.

 iv. The holder is an “accredited investor” as such term is defined in Rule 501 of Regulation D promulgated under the Securities
Act. 
 (b) Disposition of Warrant or Shares. With respect to any offer, sale or other disposition of this Warrant or any Shares
acquired pursuant to the exercise of this Warrant prior to registration of such Warrant or Shares, the holder hereof agrees to give written notice to the Company prior thereto, describing briefly the manner thereof, together with a written opinion
of such holder’s counsel, or other evidence or certification, if reasonably satisfactory to the Company, to the effect that such offer, sale or other disposition may be effected without registration or qualification (under the Securities Act as
then in effect or any federal or state securities law then in effect) of this Warrant or the Shares and indicating whether or not under the Securities Act certificates for this Warrant or the Shares to be sold or otherwise disposed of require any
restrictive legend as to applicable restrictions on transferability in order to ensure compliance with such law. Upon receiving such written notice and reasonably satisfactory opinion or other evidence, the Company, as promptly as practicable but no
later than fifteen (15) business days after receipt of the written notice and such reasonably satisfactory opinion or other evidence, shall notify such holder that such holder may sell or otherwise dispose of this Warrant or such Shares, all in
accordance with the terms of the notice delivered to the Company; provided, however, that, if (i) no Event of Default (as defined in the Loan Agreement, as defined herein) exists under the Loan and Security Agreement, dated December 15, 2022 by
and among the Company and Horizon Technology Finance Corporation (as amended from time to time, the “Loan Agreement”) or (ii) all loan obligations under the Loan Agreement have been repaid in full, the Company may withhold its
consent to such sale or other disposition if the Company, in its reasonable discretion, identifies the transferee as a competitor or potential competitor of the Company. If a 

  
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determination has been made pursuant to this Section 7(b) that the opinion of counsel for the holder or other evidence is not reasonably satisfactory to the Company, the
Company shall so notify the holder promptly with details thereof after such determination has been made. Notwithstanding the foregoing, this Warrant or such Shares may, as to such federal laws, be offered, sold or otherwise disposed of in accordance
with Rule 144 or 144A, promulgated under the Securities Act (respectively, “Rule 144” and “Rule 144A”); provided that the Company shall have been furnished with such information as the Company may reasonably
request to provide a reasonable assurance that the provisions of Rule 144 or 144A have been satisfied, including, without limitation, the information and other requirements set forth above. Each certificate representing this Warrant or the Shares
thus transferred (except a transfer pursuant to Rule 144 or 144A) shall bear a legend as to the applicable restrictions on transferability in order to ensure compliance with such laws, unless in the aforesaid opinion of counsel for the holder, such
legend is not required in order to ensure compliance with such laws. The Company may issue stop transfer instructions to its transfer agent in connection with such restrictions. 

(c) Applicability of Restrictions. Neither any restrictions of any legend described in this Warrant nor the requirements of
Section 7(b) above shall apply to any transfer of, or grant of a security interest in, this Warrant (or the Common Stock obtainable upon exercise thereof) or any part hereof (i) to a partner of the holder if the holder
is a partnership or to a member of the holder if the holder is a limited liability company, (ii) to a partnership of which the holder is a partner or to a limited liability company of which the holder is a member, (iii) to any affiliate of
the holder if the holder is a corporation, (iv) notwithstanding the foregoing, to any corporation, company, limited liability company, limited partnership, partnership, or other person managed or sponsored by Horizon Technology Finance
Corporation (“HRZN”) or in which HRZN has an interest, (v) or to a lender to the holder or any of the foregoing; provided, however, in any such transfer, if applicable, the transferee shall provide a written
certificate certifying that (A) such transfer is not a transfer for value, (B) such transfer is not being completed with a view to distribute this Warrant (or the Common Stock obtainable upon exercise thereof), (C) that the transferee
agrees to be bound by the terms of this Warrant as if an original holder hereof, and (D) any other representations as reasonably requested by the Company or required by the Company’s transfer agent to effectuate such a transfer. 

8. Rights as Shareholders; Information. No holder of this Warrant, as such, shall be entitled to vote or receive dividends or be deemed
the holder of Shares or any other securities of the Company which may at any time be issuable upon the exercise hereof for any purpose, nor shall anything contained herein be construed to confer upon the holder of this Warrant, as such, any of the
rights of a shareholder of the Company or any right to vote for the election of directors or upon any matter submitted to shareholders at any meeting thereof, or to receive notice of meetings, or to receive dividends or subscription rights or
otherwise until this Warrant shall have been exercised and the Shares purchasable upon the exercise hereof shall have become deliverable, as provided herein. Notwithstanding the foregoing, the Company will transmit to the holder of this Warrant such
information, documents and reports as are generally distributed to the holders of any class or series of the securities of the Company concurrently with the distribution thereof to the shareholders. Any information, document or report required to be
transmitted pursuant to this Section 8 shall be deemed to have been transmitted to the holder upon filing of such information, document or report by the Company on the Securities and Exchange Commission’s EDGAR system. 

  
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 9. [Reserved]  

10. Additional Rights. 

(a) Acquisition Transactions. The Company shall provide the holder of this Warrant with at least ten (10) days’ written notice
prior to closing thereof of the terms and conditions of any of the following transactions (to the extent the Company has notice thereof): (i) the sale, lease, exchange, conveyance or other disposition of all or substantially all of the
Company’s property or business, or (ii) its merger into or consolidation with any other corporation (other than a wholly-owned subsidiary of the Company), or any transaction (including a merger or other reorganization) or series of related
transactions, in which more than 50% of the voting power of the Company is disposed of (each such transaction, an “Acquisition”). Upon the written request of the Company, the holder agrees that, in the event of an Acquisition in
which the sole consideration is cash and/or Marketable Securities, either (a) the holder shall exercise its conversion or purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such
Acquisition or (b) if the holder elects not to exercise the Warrant, this Warrant will expire upon the consummation of such Acquisition. As used herein, “Marketable Securities” means securities meeting all of the following
requirements: (1) the issuer thereof is then subject to the reporting requirements of Section 13 or Section 15(d) of the Exchange Act, and is then current in its filing of all required reports and other information under the
Securities Act and the Exchange Act, (2) the class and series of shares or other security of the issuer that would be received by the holder of this Warrant in connection with a merger were such holder to exercise or convert this Warrant on or
prior to the closing thereof is then traded on a national securities exchange or over-the-counter market, and (3) such holder would not be restricted by contract or
by applicable federal and state securities laws from publicly re-selling, within six (6) months and one day following the closing of such Acquisition, all of the issuer’s shares and/or other
securities that would be received by such holder in such merger were such holder to exercise or convert this Warrant in full on or prior to the closing of such merger. 

(b) Right to Convert Warrant into Stock: Net Issuance. 

i. Right to Convert. In addition to and without limiting the rights of the holder under the terms of this Warrant, the holder shall
have the right to convert this Warrant or any portion thereof (the “Conversion Right”) into Shares as provided in this Section 10(b) at any time or from time to time during the term of this Warrant. Upon
exercise of the Conversion Right with respect to a particular number of shares subject to this Warrant (the “Converted Warrant Shares”), the Company shall deliver to the holder (without payment by the holder of any exercise price or
any cash or other consideration) that number of shares of fully paid and nonassessable Common Stock as is determined according to the following formula: 

X =     B - A     

              Y 

 

					
	Where:	  	X =	  	the number of Shares that shall be issued to holder
			
		  	Y =	  	the fair market value of one Share



  
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		  	A =	  	the aggregate Warrant Price of the specified number of Converted Warrant Shares immediately prior to the exercise of the Conversion Right (i.e., the number of Converted Warrant Shares multiplied by the Warrant
Price)
			
		  	B =	  	the aggregate fair market value of the specified number of Converted Warrant Shares (i.e., the number of Converted Warrant Shares multiplied by the fair market value of one Converted Warrant Share)


 No fractional shares of Common Stock shall be issuable upon exercise of the Conversion Right, and, if
the number of shares of Common Stock to be issued determined in accordance with the foregoing formula is other than a whole number, the Company shall pay to the holder an amount in cash equal to the fair market value of the resulting fractional
share on the Conversion Date (as hereinafter defined). For purposes of this Section 10 of this Warrant, shares of Common Stock issued pursuant to the Conversion Right shall be treated as if they were issued upon the
exercise of this Warrant. 
 ii. Method of Exercise. The Conversion Right may be exercised by the holder by the surrender of this
Warrant at the principal office of the Company together with a written statement (which may be in the form of Exhibit A-1 or Exhibit A-2 hereto) specifying
that the holder thereby intends to exercise the Conversion Right and indicating the number of shares of Common Stock subject to this Warrant which are being surrendered (referred to in Section 10(b)(i) hereof as the
Converted Warrant Shares) in exercise of the Conversion Right. Such conversion shall be effective upon receipt by the Company of this Warrant together with the aforesaid written statement, or on such later date as is specified therein (the
“Conversion Date”), and, at the election of the holder hereof, may be made contingent upon the closing of a Public Offering. Certificates for or evidence of the issuance of the shares of Common Stock issuable upon exercise of the
Conversion Right and, if applicable, a new warrant evidencing the balance of the shares of Common Stock remaining subject to this Warrant, shall be issued as of the Conversion Date and shall be delivered to the holder within thirty (30) days
following the Conversion Date. 
 iii. Determination of Fair Market Value. For purposes of this
Section 10(b), “fair market value” of a share of Common Stock as of a particular date (the “Determination Date”) shall mean (x) if the Conversion Right is exercised in connection with and
contingent upon a Public Offering, then the price such shares of Common Stock are sold to the public as specified in the final prospectus or final prospectus supplement with respect to such offering, and (y) if the Conversion Right is not
exercised in connection with and contingent upon a Public Offering, then as follows: 
 A. If traded on a nationally
recognized securities exchange, inter-dealer quotation system or over-the-counter market (each a “Trading Market”), the fair market value of the Common
Stock shall be deemed to be the average of the closing prices of the Common Stock on such exchange over the five (5) trading days immediately prior to the Determination Date; and 

  
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 B. If the Common Stock is not traded on a Trading Market, then the fair
market value shall be determined by the Board of Directors of the Company in its reasonable good faith judgment. 
 If closing prices or closing bid prices
are no longer reported by a Trading Market, the closing price or closing bid price shall be that which is reported by such securities exchange or other trading system at 4:00 p.m. New York City time on the applicable trading day. 

(c) Exercise Prior to Expiration. To the extent this Warrant is not previously exercised as to all of the Shares subject hereto, and if
the fair market value of one share of the Common Stock is greater than the Warrant Price then in effect, this Warrant shall be deemed automatically exercised pursuant to Section 10(b) above (even if not surrendered)
immediately before its expiration. For purposes of such automatic exercise, the fair market value of one share of the Common Stock upon such expiration shall be determined pursuant to Section 10(b)(3). To the extent this
Warrant or any portion thereof is deemed automatically exercised pursuant to this Section 10(c), the Company agrees to promptly notify the holder hereof of the number of Shares, if any, the holder hereof is to receive by
reason of such automatic exercise. 
 11. Representations and Warranties. The Company represents and warrants to the holder of this
Warrant as follows: 
 (a) This Warrant has been duly authorized and executed by the Company and is a valid and binding obligation of the
Company enforceable in accordance with its terms, subject to laws of general application relating to bankruptcy, insolvency and the relief of debtors and the rules of law or principles at equity governing specific performance, injunctive relief and
other equitable remedies. 
 (b) The Shares have been duly authorized and reserved for issuance by the Company and, when issued in accordance
with the terms hereof, will be validly issued, fully paid and nonassessable and free from preemptive rights. 
 (c) A true and correct copy
of the Company’s Certificate of Incorporation, as amended through the Date of Grant has been provided to Holder (the “Charter”). The rights, preferences, privileges and restrictions granted to or imposed upon the classes and
series of the Company’s capital stock and the holders thereof are as set forth in the Charter. 
 (d) The execution and delivery of this
Warrant are not, and the issuance of the Shares upon exercise of this Warrant in accordance with the terms hereof will not be, inconsistent with the Company’s Charter or by-laws, do not and will not
contravene any law, governmental rule or regulation, judgment or order applicable to the Company, and do not conflict with or contravene any provision of, or constitute a default under, any indenture, mortgage, contract or other instrument of which
the Company is a party or by which it is bound or require the consent or approval of, the giving of notice to, the registration or filing with or the taking of any action in respect of or by, any Federal, state or local government authority or
agency or other person, except for the filing of notices pursuant to federal and state securities laws, which filings will be effected by the time required thereby. 

  
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 (e) There are no actions, suits, audits, investigations or proceedings pending or, to the
knowledge of the Company, threatened against the Company in any court or before any governmental commission, board or authority which, if adversely determined, could have a material adverse effect on the ability of the Company to perform its
obligations under this Warrant. 
 12. Modification and Waiver. This Warrant and any provision hereof may be changed, waived,
discharged or terminated only by an instrument in writing signed by the party against which enforcement of the same is sought. 
 13.
Notices. Any notice, request, communication or other document required or permitted to be given or delivered to the holder hereof or the Company shall be delivered, or shall be sent by certified or registered mail, postage prepaid, to each
such holder at its address as shown on the books of the Company or to the Company at the address indicated therefor on the signature page of this Warrant. 

14. Binding Effect on Successors. This Warrant shall be binding upon any corporation succeeding the Company by merger, consolidation or
acquisition of all or substantially all of the Company’s assets, and all of the obligations of the Company relating to the Shares issuable upon the exercise or conversion of this Warrant shall survive the exercise, conversion and termination of
this Warrant and all of the covenants and agreements of the Company shall inure to the benefit of the successors and assigns of the holder hereof. 

15. Lost Warrants or Stock Certificates. The Company covenants to the holder hereof that, upon receipt of evidence reasonably
satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant or any stock certificate and, in the case of any such loss, theft or destruction, upon receipt of an indemnity reasonably satisfactory to the Company, or in
the case of any such mutilation upon surrender and cancellation of such Warrant or stock certificate, the Company will make and deliver a new Warrant or stock certificate, of like tenor, in lieu of the lost, stolen, destroyed or mutilated Warrant or
stock certificate. 
 16. Descriptive Headings. The descriptive headings of the various Sections of this Warrant are inserted for
convenience only and do not constitute a part of this Warrant. The language in this Warrant shall be construed as to its fair meaning without regard to which party drafted this Warrant. 

17. Governing Law. This Warrant shall be construed and enforced in accordance with, and the rights of the parties shall be governed by,
the laws of the State of Delaware. 
 18. Survival of Representations, Warranties and Agreements. All representations and warranties
of the Company and the holder hereof contained herein shall survive the Date of Grant, the exercise or conversion of this Warrant (or any part hereof) or the termination or expiration of rights hereunder. All agreements of the Company and the holder
hereof contained herein shall survive indefinitely until, by their respective terms, they are no longer operative. 
 19. Remedies. In
case any one or more of the covenants and agreements contained in this Warrant shall have been breached, the holders hereof (in the case of a breach by the Company), or the Company (in the case of a breach by a holder), may proceed to protect and
enforce their or its rights either by suit in equity and/or by action at law, including, but not limited to, an action for damages as a result of any such breach and/or an action for specific performance of any such covenant or agreement contained
in this Warrant. 

  
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 20. No Impairment of Rights. The Company will not, by amendment of its Charter or
through any other means, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all such action as may be
necessary or appropriate in order to protect the rights of the holder of this Warrant against impairment. 
 21. Severability. The
invalidity or unenforceability of any provision of this Warrant in any jurisdiction shall not affect the validity or enforceability of such provision in any other jurisdiction, or affect any other provision of this Warrant, which shall remain in
full force and effect. 
 22. Recovery of Litigation Costs. If any legal action or other proceeding is brought for the enforcement of
this Warrant, or because of an alleged dispute, breach, default, or misrepresentation in connection with any of the provisions of this Warrant, the successful or prevailing party or parties shall be entitled to recover reasonable attorneys’
fees and other costs incurred in that action or proceeding, in addition to any other relief to which it or they may be entitled. 
 23.
Entire Agreement; Modification. This Warrant constitutes the entire agreement between the parties pertaining to the subject matter contained in it and supersedes all prior and contemporaneous agreements, representations, and undertakings of
the parties, whether oral or written, with respect to such subject matter. 
 [Remainder of page intentionally left blank; signature page
follows] 

  
 -11- 












 The Company has caused this Warrant to be duly executed and delivered as of the Date of
Grant specified above. 
  

	
	EVELO BIOSCIENCES, INC.
	
	By: _______________________________
	Name: _____________________________
	Title: ______________________________
	Address: __________________
	               __________________


 [SIGNATURE PAGE TO COMMON
STOCK WARRANT (LOAN A/B/C/D/E/F]) - EVELO] 











 EXHIBIT A-1 

NOTICE OF EXERCISE 
  

	To:	 EVELO BIOSCIENCES, INC. (the “Company”) 



 

	 	1.	 The undersigned hereby: 



 

	 	☐	 elects to purchase ________ shares of Common Stock of the Company pursuant to the terms of the attached
Warrant, and tenders herewith payment of the purchase price of such shares in full, or 


  

	 	☐	 elects to exercise its net issuance rights pursuant to Section 10(b) of the attached
Warrant with respect to ________ shares of Common Stock. 


 2. Please deliver to the custodian for the selling shareholders
a stock certificate representing such ________ shares in the name of the undersigned or in such other name or names as are specified below: 
  

	
	  

	(Name)
	  

	  

	(Address)
	  

	(Tax ID Number)

 3. The undersigned represents that the aforesaid shares are being acquired for the account of the undersigned
for investment and not with a view to, or for resale in connection with, the distribution thereof and that the undersigned has no present intention of distributing or reselling such shares, all except as in compliance with applicable securities
laws. 
  

	
	  

	(Signature)


  

                         

      (Date) 











 EXHIBIT A-2 

NOTICE OF EXERCISE 
  

	To:	 EVELO BIOSCIENCES, INC. (the “Company”) 



1. Contingent upon and effective immediately prior to the closing (the “Closing”) of the Company’s public offering
contemplated by the Registration Statement on Form S-__, filed ________, 20__, the undersigned hereby: 

☐ elects to purchase ________ shares of Common Stock of the Company (or such lesser number of shares as may be sold on behalf of the
undersigned at the Closing) pursuant to the terms of the attached Warrant, or 
 ☐ elects to exercise its net issuance rights pursuant
to Section 10(b) of the attached Warrant with respect to ________ shares of Common Stock. 
 2. Please deliver to
the custodian for the selling shareholders a stock certificate representing such ________ shares in the name of the undersigned or in such other name or names as are specified below: 

 

	
	  

	(Name)
	  

	  

	(Address)
	  

	(Tax ID Number)

 3. The undersigned has instructed the custodian for the selling shareholders to deliver to the Company
$________or, if less, the net proceeds due the undersigned from the sale of shares in the aforesaid public offering. If such net proceeds are less than the purchase price for such shares, the undersigned agrees to deliver the difference to the
Company prior to the Closing. 
  

	
	  

	(Signature)


  

                         

      (Date)