U.S. flagAn official website of the United States government
                    Here's how you know **Official websites use .gov**
                            
                            A **.gov** website belongs to an official government organization in the United States.
 **Secure .gov websites use HTTPS**
                            
                            A **lock** (                            
                              A locked padlock                                                      
                            
                            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Menu Agricultural Research Service
						
                    U.S. DEPARTMENT OF AGRICULTURE
 Obesity and Metabolism Research: Davis, CA
 close



    Research

                    Research Projects
                                    Publications
                                    Collaborations
                                    News
                People

                    Staff Listing
                                    Careers


        


                    Laboratories
                        Bennett Group
                                    Huang Group
                                    Keim Group
                                    Laugero Group
                                    Newman GroupSearch small
                    Search
            
            ARS Home
                                About ARS
                                Contact Us




ARS Home Pacific West Area Davis, California Western Human Nutrition Research Center Obesity and Metabolism Research Research





- Allen, Lindsay - A
- Human Nutrition (107)

Research Project: **Location:
                            Obesity and Metabolism Research** Project Number: 2032-51530-025-038-R
                        
                        Project Type: Reimbursable Cooperative Agreement Start Date: Jan 1, 2018
                        
                        End Date: Sep 30, 2021 **Objective:**
                        
                        The study is testing the efficacy of relatively simple targeted interventions including antimicrobials to address infections and niacin in the form of nicotinamide to address infection-related inflammation and improve the intestinal microbiota of infants. **Approach:**
                        
                        The University of Virginia (UVA) is responsible for study implementation in Tanzania, intervention procedures and data and sample collection, storage and shipping. The 4-arm intervention design includes a control, niacin, antimicrobials, and niacin + antimicrobials treatment groups for the infants, and niacin and control groups for the mothers. Targeted interventions for the tryptophan-niacin pathway are as follows: Mothers: daily supplementation with nicotinamide (250mg) from delivery through 6 months postpartum; Infants: daily nicotinamide (100mg) from 6 through 18 months of age. The microbials Intervention is only applied to the infants: azithromycin 20mg/kg at 6, 9, 12, and 15 months; and nitazoxanide 100mg twice daily at 12 and 15 months. Human milk samples are collected at two time points. ARS-Western Human Nutrition Center is responsible for breast milk analyses for nicotinamide and other B-vitamins (2 x 1200 samples), additional niacin vitamers (2 x 600 samples),and free and total tryptophan (2 x 600 samples).


Return to top


Connect with ARS Sign up


ARS Home
                            USDA.gov
                            Plain Writing
                            Policies & Links
                            Civil Rights Statements
                            FOIA
                            Accessibility Statement
                            Privacy Policy
                            Non-Discrimination Statement
                            Quality of Information
                            USA.gov
                            WhiteHouse.gov