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SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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FORM 10-K

(Mark One)



|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

For the fiscal year ended December 31, 2005

OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

For the transition period from  to

Commission
File Number 0-19651

GENAERA CORPORATION

(Exact name of registrant as specified in its charter.)



|                                                               |  |                                  
|-------------------------------------------------------------- |  | ---------------------------------
|Delaware                                                       |  | 13-3445668                       
|(State or other jurisdiction of incorporation or organization) |  | (IRS Employer Identification No.)



|                                         |  |           
|---------------------------------------- |  | ----------
|5110 Campus Drive, Plymouth Meeting, PA  |  | 19462     
|(Address of principal executive offices) |  | (Zip Code)

Registrants telephone number, including area code: (610) 941-4020

SECURITIES REGISTERED PURSUANT TO SECTION 12(b) OF THE ACT:



|                      |  |                                            
|--------------------- |  | -------------------------------------------
|None                  |  | N/A                                        
|(Title of each class) |  | (Name of each exchange on which registered)

SECURITIES REGISTERED PURSUANT TO SECTION 12(g) OF THE ACT:

Common Stock, $.002 par value per share

(Title of Class)

Indicate by check mark if the registrant is a well-known, seasoned issuer, as defined in Rule 405 of the Securities Act.
YES ̈NO  x

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 (the
Act). YES ̈NO   x

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Act during the preceding 12 months
(or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. YES  x    NO ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrants knowledge, in definitive proxy
or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer or a non-accelerated filer. See definition of accelerated
filer and large accelerated filer in Rule 12b-2 of the Act.

Large accelerated filer ̈Accelerated filer   x           Non-accelerated filer ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act.
YES ̈NO  x

The aggregate market value of common stock held by non-affiliates of the registrant was approximately $97,276,946 as of June 30, 2005, the last
business day of the registrants most recently completed second fiscal quarter. Such aggregate market value was computed by reference to the closing price of the common stock as reported on the National Market System of The Nasdaq Stock Market
on June 30, 2005. For purposes of this calculation only, the registrant has defined affiliates as all directors and executive officers as of June 30, 2005 and any stockholder whose ownership exceeds 10% of the common stock outstanding as
of June 30, 2005. The number of shares of the registrants common stock outstanding as of June 30, 2005 was 57,221,733.

Number of shares of Common Stock outstanding as of March 1, 2006 was 68,778,733.

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the Definitive Proxy Statement for the Registrants 2006 Annual Meeting of Stockholders to be filed within 120 days after
the end of the fiscal year covered by this Annual Report on Form 10-K are incorporated by reference into Part III of this Form 10-K.



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GENAERA CORPORATION

ANNUAL REPORT ON FORM 10-K

FOR THE YEAR ENDED DECEMBER 31, 2005

INDEX



|               |  |         |  |                                                                                                              |  |         
|-------------- |  | ------- |  | ------------------------------------------------------------------------------------------------------------ |  | --------
|               |  |         |  | Description                                                                                                  |  | Page No.
|Part I         |  | Item 1  |  | Business                                                                                                     |  | 1       
|               |  | Item 1A |  | Risk Factors                                                                                                 |  | 8       
|               |  | Item 1B |  | Unresolved Staff Comments                                                                                    |  | 15      
|               |  | Item 2  |  | Properties                                                                                                   |  | 15      
|               |  | Item 3  |  | Legal Proceedings                                                                                            |  | 15      
|               |  | Item 4  |  | Submission of Matters to a Vote of Security Holders                                                          |  | 16      
|               |  |         | 
|Part II        |  | Item 5  |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities |  | 17      
|               |  | Item 6  |  | Selected Financial Data                                                                                      |  | 19      
|               |  | Item 7  |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                        |  | 20      
|               |  | Item 7A |  | Quantitative and Qualitative Disclosures About Market Risk                                                   |  | 25      
|               |  | Item 8  |  | Financial Statements and Supplementary Data                                                                  |  | 26      
|               |  | Item 9  |  | Changes in and Disagreements With Accountants on Accounting and Financial Disclosure                         |  | 26      
|               |  | Item 9A |  | Controls and Procedures                                                                                      |  | 26      
|               |  | Item 9B |  | Other Information                                                                                            |  | 27      
|               |  |         | 
|Part III       |  | Item 10 |  | Directors and Executive Officers of the Registrant                                                           |  | 28      
|               |  | Item 11 |  | Executive Compensation                                                                                       |  | 28      
|               |  | Item 12 |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters               |  | 28      
|               |  | Item 13 |  | Certain Relationships and Related Transactions                                                               |  | 28      
|               |  | Item 14 |  | Principal Accountant Fees and Services                                                                       |  | 28      
|               |  |         | 
|Part IV        |  | Item 15 |  | Exhibits and Financial Statement Schedules                                                                   |  | 29      
|               | 
|Signatures     |  | 33     
|               | 
|Certifications |  |        



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PART I



|ITEM 1. | BUSINESS
|------- | --------

FORWARD-LOOKING STATEMENTS

Our disclosure and analysis in this Annual Report on Form 10-K contains some forward-looking statements. Forward-looking statements give our current
expectations or forecasts of future events. You can identify these statements by the fact that they do not relate strictly to historical or current facts. Such statements may include words such as anticipate, estimate,
expect, project, intend, plan, believe, hope and other words and terms of similar meaning. In particular, these include, among others, statements relating to present or
anticipated scientific progress, development of potential pharmaceutical products, future revenues, capital expenditures, research and development expenditures, future financing and collaborations, personnel, manufacturing requirements and
capabilities, the impact of new accounting pronouncements and other statements regarding matters that are not historical facts or statements of current condition.

There are important factors that could cause actual results to differ materially from those expressed or implied by such forward-looking statements, including those addressed below under Risk Factors.

We undertake no obligation (and expressly disclaim any such obligation) to publicly update any forward-looking statements, whether
as a result of new information, future events or otherwise, except as required by law. You are advised, however, to consult any further disclosures we make on related subjects in our filings with the United States Securities and Exchange Commission
(SEC), all of which are available in the SEC EDGAR database at www.sec.gov and from us.

OVERVIEW

Genaera Corporation is a biopharmaceutical company committed to developing medicines to address substantial unmet medical needs in major pharmaceutical
markets. We were first incorporated in the State of Delaware in 1987 and are headquartered in Plymouth Meeting, Pennsylvania. Our research and development efforts are focused on anti-angiogenesis and respiratory diseases. EVIZON (squalamine
lactate), our lead product candidate, is being developed to treat ophthalmic indications, specifically the wet form of age-related macular degeneration (AMD). Squalamine lactate is also being developed as our second product candidate for
the treatment of cancerous solid tumors. Our third product candidate, LOMUCIN (talniflumate), is being developed to treat the overproduction of mucus secretions involved in chronic respiratory disease. Our fourth product candidate,
interleukin-9 (IL9) antibody, is a respiratory treatment based on the discovery of a genetic cause of asthma. Additionally, we have a number of discovery research programs focused on the treatment of obesity, infectious diseases and inflammatory
disorders.

We have no products available for sale and have incurred losses since our inception. Because substantially all of our potential
products currently are in research, preclinical development or the early or middle stages of clinical testing, revenues from sales of any products will not occur for at least the next several years, if at all. As a result, we will need to raise
substantial additional funds in the future to continue our research and development programs and to commercialize our potential products. We regularly explore alternative means of financing our operations and seek funding through various sources,
including public and private securities offerings, collaborative arrangements with third parties and other strategic alliances and business transactions.

CLINICAL DEVELOPMENT PROGRAMS

Squalamine Lactate

Squalamine lactate (squalamine) is a unique, first-in-class, synthetic small molecule administered systemically that directly interrupts and reverses multiple facets of angiogenesis, a
fundamental process by which new blood vessels are formed, and is considered an anti-angiogenic substance. Working within activated endothelial cells, squalamine, an aminosterol, inhibits growth factor signaling including VEGF signaling,
thereby resulting in endothelial cell inactivation and, in certain cases, apoptosis. Squalamine has exhibited reproducible anti-angiogenic properties in a number of in vitro and in vivo assays, including animal cancer and eye disease models, across
independent laboratories.

EVIZON (squalamine lactate)

EVIZON, our lead product candidate, is currently being studied for the treatment of the wet form of age-related macular degeneration. AMD occurs in two types: the dry form and the more
severe wet form. Dry AMD, the more common and milder form of AMD, results in varying forms of sight loss and may or may not develop into the wet form. Wet AMD



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involves the growth of abnormal blood vessels, or choroidal neovascularization, under the central part of the retina, the macula. Although the wet form of
AMD accounts for a small percentage of all AMD, it is responsible for the majority of severe vision loss associated with AMD.

In 2004, we
initiated three Phase II clinical trials following the United States Food and Drug Administrations (FDA) clearance of our investigational new drug (IND) application to conduct clinical trials of EVIZON in ophthalmic indications including the
treatment of wet AMD. In 2005, we completed enrollment in two of our three Phase II clinical trials of EVZON for the treatment of wet AMD. MSI-1256F-207 was a pharmacokinetic and safety trial designed to evaluate 18 patients with wet AMD at three
different doses of EVIZON. Vision outcomes from this study suggested that 40 mg of EVIZON administered for four weeks stabilized vision for all patients and improved vision for a subset of patients. Subjects from this study were permitted to
continue in a twelve-month follow-up study of infusion interval and long-term safety of EVIZON (MSI-1256F-211). MSI-1256F-208, an exploratory trial, evaluated three different doses (10 mg, 20 mg and 40 mg) of EVIZON in combination with Visudyne® treatment in 45 patients with wet AMD. The study met
its primary endpoint, demonstrating the safety of the 10, 20 and 40 mg EVIZON doses used concomitantly with Visudyne® treatment. Our third and ongoing Phase II study, MSI-1256F-209 (Study 209), is designed to evaluate the safety and efficacy of EVIZON as
first-line therapy in 100 patients with wet AMD over a two-year period. Enrollment was completed in July 2005 and recently released interim data showed that the 40 mg dose was safe and active in stabilizing vision in patients with wet AMD.
Twelve-month data is expected in the second half of 2006. In January 2006, we announced our plans to initiate a fourth Phase II clinical trial, MSI-1256F-212 (Study 212). This study will be an open-label, pharmacodynamic and safety trial
designed to evaluate up to 36 patients with wet AMD treated with EVIZON at four dose levels (40 mg, 80 mg, 120 mg and 160 mg) over a sixteen-week period and is expected to be completed in 2006.

In addition to our Phase II clinical trials, we are currently conducting the first of two planned global Phase III clinical trials (MSI-1256F-301) of
EVIZON. Both MSI-1256F-301 (Study 301) and MSI-1256F-302 (Study 302) are multi-center, randomized, double-masked, controlled trials designed to evaluate two systemically-administered doses of EVIZON (40 mg and 20 mg) versus
placebo. The primary objectives of these studies are to demonstrate safety and significant clinical benefit of EVIZON therapy on visual acuity in the study eye at one year. Planned secondary analyses include evaluation of changes in visual acuity
from baseline in the study eye at year two and change in visual acuity in fellow eyes affected with wet AMD and quality of life at years one and two. In March 2006, we announced that enrollment in Study 302 would not commence until results from
Study 212 are available and that adaptations to Study 301 may be made as a result of further analysis of our recently released interim data from Study 209 and discussions with the FDA.

EVIZON has been granted Fast Track designation by the FDA and has been selected for participation in the FDAs Continuous Marketing Application
(CMA) Pilot 2 program.

Squalamine Lactate in Cancer

We have conducted Phase II clinical trials of squalamine for the treatment of solid tumors. Currently, we have an ongoing Phase II clinical study of squalamine for the treatment of prostate cancer. This cancer study
will evaluate intravenously administered squalamine in combination with leading chemotherapeutics or accepted interventions in this indication.

IL9
Antibody Therapeutics

Our first genomics-based program is focused on the development of a blocking antibody to interleukin-9 (IL9)
to treat a root cause of asthma. Our functional genomic studies have demonstrated the broad role of IL9 as an etiologic agent in asthma. The IL9 gene varies in structure and function and as a result may have an important role in a genetic
predisposition to asthma and allergic reactions. Our scientific studies and independent peer-reviewed publications indicate that IL9 controls other well-known factors involved in promoting lung inflammation in asthma, including a group of proteins
that modulate the growth and functional activities of immune cells. Genaera has developed a patent position around IL9 having first discovered and documented a role for this cytokine in asthma. Our patent position around IL9 includes patents
licensed exclusively from the Ludwig Institute for Cancer Research (LICR) as well as patents owned jointly with LICR.

In April 2001, we
entered into a collaborative agreement with MedImmune, Inc. (MedImmune), to develop and commercialize therapies related to our IL9 program. Pursuant to the agreement, MedImmune provided funding of $2.5 million for research and development activities
at Genaera over a two-year period from April 2001 through April 2003. By the end of the two-year period, licensed technology had been transferred to MedImmune, which assumed responsibility for development and commercialization efforts on the IL9
program. In addition to the research and development funding, MedImmune agreed to reimburse Genaera for certain external costs we incur in connection with the IL9 program. Under the agreement, we received $0.5 million based on the completion of a
contractual milestone in 2004 and we could also receive up to $54.5 million based on the successful completion of future milestones. We are also entitled to royalties on sales of commercial products resulting from



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the collaboration. As a result of our limited control over the development plan and the timing of milestones, we cannot estimate the timing or receipt of
milestone payments and do not expect to receive a substantial portion of these milestone payments within the next five years. Each party has the right to terminate the agreement upon notice to the other party.

LOMUCIN (talniflumate)

Our second
genomics-based program has focused on the fundamental biology of mucus over-production in chronic respiratory patients. Efforts to identify specific gene targets and validate these targets for therapeutic development have led to the identification
of small molecules to inhibit the over-production of mucin, or mucoregulators. Our scientists have identified hCLCA1, a chloride channel found in humans, and demonstrated a relationship between hCLCA1 and abnormal mucus production.

LOMUCIN (talniflumate) is an orally available, small molecule inhibitor of the hCLCA1 channel and potential mucoregulator. LOMUCIN
is a known compound that was discovered, developed and marketed as an anti-inflammatory drug by Laboratorios Bago of Buenos Aires, Argentina, an independent pharmaceutical company in South America. The effects of talniflumate in blocking hCLCA1 and
mucus over-production were discovered by our scientists and we have been issued a patent protecting uses of talniflumate and certain 2-aminophenyl acetic compounds to treat diseases characterized by mucin production. We have an exclusive license
with Laboratorios Bago to develop and commercialize talniflumate as a mucoregulator drug in all major pharmaceutical markets, including the United States, Europe and Japan.

Our current clinical development of LOMUCIN is focused on its use in cystic fibrosis patients. Early clinical evaluation of LOMUCIN in cystic fibrosis
was supported by a contingent award of up to $1.7 million from Cystic Fibrosis Foundation Therapeutics (CFFT), the nonprofit drug development affiliate of the Cystic Fibrosis Foundation. In 2005, the award was amended to provide up to $2.35 million
in milestone-driven, matching funds from CFFT to support a pivotal multi-center, randomized, double-blind, placebo-controlled Phase II clinical trial of LOMUCIN in approximately 200 individuals with cystic fibrosis. This award will be paid to us
from time to time upon the achievement of certain milestones. Grant amounts received would become refundable to the CFFT upon marketing approval by the FDA or upon our election not to enter Phase III clinical trials or not to commercialize the
product within two years of the satisfaction of development milestones, assuming the achievement of statistically significant results. CFFT is also due a royalty on net sales of any resultant product of up to 1.6% based upon the amount of funding
ultimately provided by CFFT. At December 31, 2005, we had received approximately $1.7 million of this grant support.

In September
2005, we announced the start of a pivotal, multi-center, randomized, double-blind, placebo-controlled Phase II clinical trial to evaluate the use of LOMCIN in 200 individuals with cystic fibrosis. The study will assess the safety and efficacy of
LOMUCIN oral tablets on pulmonary function and related symptoms. A previous exploratory Phase II study demonstrated a trend toward better lung function in people with cystic fibrosis who took LOMUCIN compared to those receiving placebo tablets and
found that LOMUCIN was well tolerated in the study.

PRE-CLINICAL & RESEARCH PROGRAMS

Obesity Therapeutic Program

Trodusquemine,
formerly known as trodulamine (also referred to in scientific literature as MSI-1436), is a natural aminosterol product candidate. Our scientists have demonstrated the ability to prevent abnormal weight gain and reduce the weight of genetically
altered mice, generally very obese mice, to that of a normal healthy mouse with trodusquemine. Body weights of healthy animals, including animals with diet-induced obesity, also have been reduced through the administration of trodusquemine. Our
researchers have shown preclinical efficacy with trodusquemine and demonstrated that animal food intake can be regulated in a reversible manner, leading to changes in body weight. Preclinical data on trodusquemine demonstrate it is a potent appetite
suppressant with the ability to normalize fasting blood sugar, as well as high blood cholesterol levels, resulting from weight loss in obese animals. With trodusquemine, we are targeting the approximately 10 to 12 million Americans who are
classified medically as significantly obese. While the trodusquemine molecule is very different in function, it has a similar chemical structure to squalamine, which would enable us to make more efficient use of internal and external resources
already utilized for squalamine in its development. Preclinical results with trodusquemine suggest that additional work on formulation and delivery of this compound in a safer and more convenient fashion would be the next milestones for development.
We expect to file an IND application with the FDA for the use of trodusquemine in clinical trials by the end of 2006.

Other Aminosterol Programs

In addition to squalamine and trodusquemine, our discovery of natural aminosterols has been complemented by a combinatorial
chemistry and biology program that has produced many synthetic aminosterols. These natural aminosterols and



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their synthetic analogues are being studied as a class of agents that are able to block cellular activation in specific cell types. Our lead compounds have
demonstrated sufficient efficacy in preclinical models to encourage our pursuit of additional research that could lead to the development of a new treatment for inflammatory disorders. These anti-inflammatory aminosterols represent a novel class of
compounds with significant potential for a wide range of systemic and topical anti-inflammatory indications. In February 2002, we received a Phase II Small Business Innovative Research program grant from the National Institutes of Health (NIH) in
the amount of $0.8 million to support this program. The grant extended over a two-year period, which ended in February 2004. In February 2004, we notified the NIH of a no-cost extension to the original budget period by twelve months. As a result of
the notification, the grant was extended through February 2005.

Infectious Disease Program

Prior to 2000, LOCILEX Cream, a topical cream antibiotic for the treatment of infection in diabetic foot ulcers, had been our lead product development
candidate. In July 1999, LOCILEX Cream failed to obtain approval from the FDA, and we have since terminated our manufacturing agreements required to further develop this product candidate and refocused our near-term product development efforts on
our other programs. Near-term commercialization of LOCILEX Cream will not occur, and we will generate no revenues from LOCILEX Cream in the near future. We continue to seek new opportunities that will enable us to capitalize on our past development
efforts in this program and related programs.

In February 1997, we entered into a development, supply and distribution agreement in North
America with GlaxoSmithKline for LOCILEX Cream. GlaxoSmithKline paid us $10.0 million under this agreement, which we received in 1997. As a result of the FDAs decision in July 1999 not to approve LOCILEX Cream, we terminated our manufacturing
agreements required to further develop this product candidate. The GlaxoSmithKline agreement also gives GlaxoSmithKline rights to terminate the arrangement, and, under certain conditions, the right to negotiate for rights to another Genaera product
development candidate. Although we are not pursuing the commercialization of LOCILEX Cream, GlaxoSmithKline remains our exclusive sales, marketing and distribution partner for the North American territory for LOCILEX Cream.

Other

In prior years, we have conducted
feasibility studies in a number of other areas, including animal-host defense systems and uses for magainin peptides other than in infectious diseases. In November 2002, we announced that we and E.I. du Pont de Nemours entered into an option
agreement for certain of our antimicrobial peptide intellectual property. The agreement had an initial term of 18 months that ended in April 2004 and was extended to December 31, 2005. The agreement provided reimbursement to us for certain
patent-related expenses. We no longer conduct significant research and development activities in these areas as a result of a reprioritization of our corporate goals. Any of these programs could become more significant over the next 12 months;
however, there can be no assurance that any of these or our other programs will generate viable product opportunities.

RESEARCH AND DEVELOPMENT COSTS

We have incurred costs of $21.8 million, $14.0 million and $7.9 million for research and development in the years ended
December 31, 2005, 2004 and 2003, respectively. See ITEM 7. Managements Discussion and Analysis of Financial Condition and Results of Operations and ITEM 8. Financial Statements and Supplementary Data for
additional information.

COMMERCIAL ARRANGEMENTS

We believe collaborations allow us to leverage our scientific and financial resources and gain access to markets and technologies that would not otherwise be available to us. In the long term, development and
marketing arrangements with established companies in the markets in which our potential products will compete may provide us with more efficient development and marketing abilities and may, accordingly, conserve our resources. We expect that we will
seek additional development and marketing arrangements for most of the products we may develop. From time to time, we hold discussions with potential collaborators.

CONTRACT MANUFACTURING

We have no current plans to establish a commercial manufacturing facility. We
depend upon various contract manufacturers for clinical trial manufacturing of our proposed products and expect to continue to rely on third parties for any commercial-scale manufacturing. We require all of our third-party manufacturers to produce
our active pharmaceutical ingredients and finished products in accordance with all applicable regulatory standards.



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GOVERNMENT REGULATION

Our development, manufacture, and potential sale of therapeutics are subject to extensive regulation by United States and foreign governmental authorities.

Regulation of Pharmaceutical Products in the United States

The FDA regulates our product candidates currently being developed as drugs or biologics in the United States. New drugs are subject to regulation under the Federal Food, Drug, and Cosmetic Act, and biological
products, in addition to being subject to certain provisions of that Act, are regulated under the Public Health Service Act. Both statutes and the regulations promulgated thereunder govern, among other things, the testing, manufacturing, safety,
efficacy, labeling, storage, record keeping, and advertising and other promotional practices involving biologics or new drugs, as the case may be. FDA approval or other clearances must be obtained before clinical testing, and before manufacturing
and marketing of new biologics and drugs.

Obtaining FDA approval historically has been a costly and time-consuming process. Generally, in
order to gain FDA premarket approval, a developer first must conduct preclinical studies in the laboratory and in animal model systems to gain preliminary information on an agents effectiveness and to identify any safety problems. The results
of these studies are submitted as a part of an IND for a drug or biologic which the FDA must review before human clinical trials of an investigational drug or device can begin. The IND includes a detailed description of the clinical investigations
to be undertaken.

In order to commercialize any products, we or our collaborators must sponsor and file an IND and be responsible for
initiating and overseeing the clinical studies to demonstrate the safety, effectiveness, and quality that are necessary to obtain FDA approval of any such products. For INDs sponsored by us or our collaborators, we or our collaborators will be
required to select qualified investigators (usually physicians) to supervise the administration of the products, and ensure that the investigations are conducted and monitored in accordance with FDA regulations, including the general investigational
plan and protocols contained in the IND.

Clinical trials of drugs normally are done in three phases, although the phases may overlap.
Phase I trials are concerned primarily with the safety of the drug, involve a small group typically ranging from 15 - 40 subjects, and may take from six months to over one year to complete. Phase II trials typically involve 30 - 200 patients and are
designed primarily to demonstrate safety and preliminary effectiveness in treating or diagnosing the disease or condition for which the drug is intended, although short-term side effects and risks in people whose health is impaired may also be
examined. Phase III trials are expanded clinical trials with larger numbers of patients that are intended to evaluate the overall benefit-risk relationship of the drug and to gather additional information for proper dosage and labeling of the drug.
Phase III clinical trials generally take two to five years to complete, but may take longer. The FDA receives reports on the progress of each phase of clinical testing, and it may require the modification, suspension, or termination of clinical
trials if it concludes that an unwarranted risk is presented to patients, or, in Phase II and III, if it concludes that the study protocols are deficient in design to meet their stated objectives.

If clinical trials of a new product are completed successfully, the sponsor of the product may seek FDA marketing approval. If the product is regulated
as a biologic, the FDA will require the submission and approval of a Biologics License Application (BLA) before commercial marketing of the biologic. If the product is classified as a new drug, an applicant must file a New Drug Application (NDA)
with the FDA and receive approval before commercial marketing of the drug. The BLA or NDA must include detailed information about the product and its manufacture and the results of product development, preclinical studies and clinical trials.

The testing and approval processes require substantial time and effort and there can be no assurance that any approval will be granted on
a timely basis, if at all. BLAs and NDAs submitted to the FDA can take more than one to two years to receive approval. If questions arise during the FDA review process, approval can take more than five years. Notwithstanding the submission of
relevant data, the FDA may ultimately decide that the BLA or NDA does not satisfy its regulatory criteria for approval and deny approval, require additional clinical studies, or require demonstration of compliance with Good Manufacturing Practices
(GMPs). In addition, the FDA may condition marketing approval on the conduct of specific post-marketing studies to further evaluate safety and effectiveness. Even if FDA regulatory clearances are obtained, a marketed product is subject to continual
regulatory requirements and review relating to GMPs, adverse event reporting, promotion and advertising, and other matters. Later discovery of previously unknown problems or failure to comply with the applicable regulatory requirements may result in
restrictions on the marketing of a product or withdrawal of the product from the market as well as possible civil or criminal sanctions.



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Regulation of Pharmaceutical Products Outside of the United States

The development and commercialization of our product candidates outside of the United States is subject to foreign local and national regulatory
requirements. The requirements that we must satisfy to obtain regulatory approval by governmental agencies in other countries prior to commercialization of our products in such countries can be as rigorous, costly and uncertain as those that are
encountered in the United States.

Other

In addition to the foregoing, our business is and will be subject to regulation under various state and federal environmental laws, including the Occupational Safety and Health Act, the Resource Conservation and
Recovery Act and the Toxic Substance Control Act. These and other laws govern our use, handling and disposal of various biological, chemical and radioactive substances used in and wastes generated by our operations. We cannot predict whether state
or federal regulators and agencies will impose new regulatory restrictions on the marketing of biotechnology products.

PATENTS, LICENSES AND
PROPRIETARY RIGHTS

We actively seek to protect our product candidates and proprietary information by means of United States and foreign
patents, trademarks and contractual arrangements. Our success depends, in part, on our ability to develop and maintain a strong patent position for our products and technologies both in the United States and certain other countries where patent laws
are enforced and pharmaceutical markets are deemed to be meaningful to us and our current and future collaborators. As with most biotechnology and pharmaceutical companies, our patent position is highly uncertain and involves complex legal and
factual questions.

To date, we own, co-own or have licensed on an exclusive basis a total of 80 patent applications and issued patents in
the United States, of which we own or co-own 66 and we license on an exclusive basis 14. We own, co-own or have licensed on an exclusive basis a total of 145 patent applications and issued patents in countries other than the United States.

We own several patents and patent applications for the use of squalamine as an anti-angiogenic, including methods for the treatment of
cancer and neovascularization in the eye. One of these patents is to the compounds combination therapy with other anti-cancer agents and will expire in 2017, while another patent covers the treatment of age-related macular degeneration,
retinopathy of prematurity and diabetic retinopathy and will expire in 2015. We also own patents covering methods and intermediates in the manufacturing process of squalamine and trodusquemine that expire in 2017 and 2018. We own a composition of
matter patent for the trodusquemine compound, which expires in 2014. We also own a patent for the use of trodusquemine as an anti-obesity agent and other indications that expires in 2015. We own two patents for the use of anti-IL9 or anti-IL9
receptor antibodies for the treatment of asthma and related disorders that expire in 2016. We also have U.S. patents covering the composition of a matter for a mucoregulator target and another patent covering methods for screening for mucoregulator
compounds, both of which expire in 2019. We own a patent on the use of talniflumate and related mucoregulator compounds for treating various conditions where mucous is overproduced, which expires in 2021.

The expiration date of each of these patents is subject to extension depending upon the future research and development program timelines. We have filed
several other applications across our research and development programs and intend to file additional applications, as appropriate, for patents on new compounds, products or processes discovered or developed through the application of our
technology.

We have rights to several patents and patent applications under certain license agreements pursuant to which we expect to owe
royalties on sales of products that incorporate issued valid patent claims. In particular, we have licensed from the Ludwig Institute of Cancer Research specific technologies related to our IL9 program, the earliest of which expires in 2009. In
addition, we have licensed from the Childrens Hospital of Philadelphia the composition of matter patent for the squalamine compound, which expires in 2012. These patents are subject to extensions by their owners depending upon the future
research and development program timelines. Additionally, certain of these agreements also provide that if we elect not to pursue the commercial development of any licensed technology, or do not adhere to an acceptable schedule of commercialization,
then our exclusive rights to such technology may terminate. We also conduct or collaborate on research at certain institutions, and these relationships may provide us with technology that is owned, licensed or for which we have an option to license.

In addition, we rely on unpatented proprietary technologies, unpatentable skills, knowledge and experience of our scientific and technical
personnel, as well as those of our advisors, consultants and other contractors and other intellectual property (know-how) in the development of our product candidates. To help protect our proprietary know-how that is not patentable, and
for inventions for which patents may be difficult to enforce, we rely on trade secret protection and confidentiality agreements to protect our interests. To this end, we require employees, consultants and advisors to enter into agreements that
prohibit the disclosure of confidential information and, where applicable, require disclosure and assignment to us of the ideas, developments, discoveries and inventions that arise from their activities for us. These confidentiality agreements
require that our



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employees, consultants and advisors do not bring to us, or use without proper authorization, any third partys proprietary technology.

We have trademark protection for the product candidate name LOMUCIN and are currently seeking U.S. registration of this trademark. We also have trademark
protection for the product candidate name EVIZON and are currently seeking U.S. registration of this trademark.

COMPETITION

The pharmaceutical industry is characterized by intense competition. Many companies, research institutions and universities are conducting research and
development activities in a number of areas similar to our fields of interest. Most of these entities have substantially greater financial, technical, manufacturing, marketing, distribution and other resources. We also may face competition from
companies using different or advanced techniques that could render our products obsolete.

We expect technological developments in the
biopharmaceutical field to occur at a rapid rate and expect competition to intensify as advances in this field are made. Colleges, universities, governmental agencies and other public and private research organizations are becoming more active in
seeking patent protection and licensing arrangements to collect royalties for use of technology that they have developed, some of which may be directly competitive with our technology. In addition, these institutions, along with pharmaceutical and
specialized biotechnology companies, can be expected to compete with us in recruiting highly qualified scientific personnel.

Many
companies are working to develop and market products intended for the disease areas we are targeting, including AMD, cancer and respiratory diseases. A number of major pharmaceutical companies have significant franchises in these disease areas and
can be expected to invest heavily to protect their interests. With respect to AMD, anti-angiogenic agents are under development at a number of biopharmaceutical companies, including Alcon, Inc., Bausch & Lomb, Inc., Genentech, Inc.,
Miravant Medical Technologies, OSI Pharmaceuticals, Inc. and QLT, Inc., as well as multiple large pharmaceutical companies. For cancer, anti-angiogenic agents are under development at a number of biopharmaceutical companies, including EntreMed,
Inc., Genentech, Inc. and Imclone Systems, Inc., as well as other multiple large pharmaceutical companies. In the respiratory field, other biopharmaceutical companies also have reported the discovery of genes relating to asthma and other respiratory
diseases, including Genentech, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc., as well as multiple large pharmaceutical companies.

EXECUTIVE
OFFICERS

Our current executive officers are as follows:



|                            |  |     |  |                                                                                 
|--------------------------- |  | --- |  | --------------------------------------------------------------------------------
|Name                        |  | Age |  | Position                                                                        
|John L. Armstrong, Jr., MBA |  | 62  |  | President and Chief Executive
Officer                                           
|                            |  |    
|John A. Skolas, JD, MBA     |  | 53  |  | Executive Vice President, Chief Financial Officer,
General Counsel and Secretary

Mr. Armstrong has served as our President and Chief Executive Officer since January
2006. Prior to that, Mr. Armstrong had served as our President and Chief Operating Officer since July 2005. In July 2004, Mr. Armstrong was promoted to our Executive Vice President and Chief Operating Officer. Prior to that, he had served
as our Executive Vice President since joining the Company in October 2003. Mr. Armstrong has over thirty-eight years of increasing responsibility in the pharmaceutical industry, with a manufacturing emphasis. Prior to Genaera, he served as
Chief Executive Officer of Mills Biopharmaceuticals, a subsidiary of UroCor, Inc., and as Vice President of Business Development at UroCor from December 1999 to November 2001. Prior to that, Mr. Armstrong served as President and Chief Operating
Officer at Oread, Inc. from February 1998 to August 1999. Mr. Armstrong spent from 1991 to 1998 with the DuPont Merck Pharmaceutical Company where he served in various executive positions, including as President of ENDO Laboratories, and
President of the global manufacturing/quality division. Prior to that, Mr. Armstrong served in numerous roles of increasing responsibility in manufacturing operations at Merck, Sharp and Dohme, Stuart Pharmaceuticals and Marion Merrell Dow.
Mr. Armstrong earned his MBA from Century University in 1993.

Mr. Skolas was promoted to Executive Vice President, Chief
Financial Officer, General Counsel and Secretary in July 2004. Prior to that, he had served as our Senior Vice President, Chief Financial Officer, General Counsel and Secretary since October 2003. Prior to that, Mr. Skolas served as a
consultant and acting chief financial officer for early stage biotechnology companies. From 2000 through 2001, Mr. Skolas was Chief Financial Officer of Valigen, a privately held genomics company. From 1999 through 2000, Mr. Skolas served
as Chief Financial Officer of Coelacanth Corporation (now the pharmaceuticals division of Lexicon Genetics). From 1997 until 1999, Mr. Skolas served as Chief Financial Officer and General Counsel of



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Phytoworks, Inc. From 1988 until 1997, Mr. Skolas served in various executive positions with EMI Group, PLC, including five years as President and
General Counsel of its subsidiary EMI Group Inc. Mr. Skolas early career included law practice as a partner in Muchin, Muchin, Bendix & Skolas S.C. and accounting practice as a Tax Specialist for Coopers & Lybrand, CPA.
Mr. Skolas obtained a CPA certificate from the State of Iowa in 1976. He earned an MBA from Harvard Business School in 1988 and a JD from the University of Wisconsin in 1977.

Officers are elected or appointed by the board of directors to serve until the appointment or election and qualification of their successors or their
earlier termination or resignation.

EMPLOYEES

As of December 31, 2005, we had 46 full-time employees. No employees are covered by collective bargaining agreements and we consider relations with our employees to be good.

AVAILABLE INFORMATION

We make available free of
charge on or through our internet website, www.genaera.com, our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and amendments to these reports filed or furnished pursuant to Section 13(a) or 15(d) of the
Securities Exchange Act of 1934 as soon as reasonably practicable after we electronically file such material with, or furnish it to, the SEC.



|ITEM 1A. | RISK FACTORS
|-------- | ------------

Any investment in shares of our common stock involves a high degree of risk. You
should carefully consider each of the following risk factors together with the other information presented in this Annual Report on Form 10-K.

Risks
Related to Our Business

If we do not raise additional capital, we may not be able to continue our research and development programs. We may
never commercialize any products.

We maintained cash, cash equivalents and short-term investments of $32.2 million at December 31,
2005. We believe these resources are sufficient to sustain operations and meet our research and development goals at least through 2006. However, we will need to raise substantial additional funds in the future to continue our research and
development programs and to commercialize our potential products. If we are unable to raise additional funds, we may be unable to complete our development activities for any of our proposed products.

We regularly explore alternative means of financing our operations and seek funding through various sources, including public and private securities
offerings, collaborative arrangements with third parties and other strategic alliances and business transactions. We currently do not have any commitments from other parties to provide us additional funds and may be unable to obtain sufficient
funding in the future on acceptable terms, if at all. If we cannot obtain funding, we will need to delay, scale back or eliminate research and development programs or enter into collaborations with third parties to commercialize potential products
or technologies that we might otherwise seek to develop or commercialize ourselves, or seek other arrangements.

Our capital raising efforts may dilute
stockholder interests.

If we raise additional capital by issuing equity securities or securities convertible into equity, the issuance
may result in ownership dilution to our stockholders and our share price may decline. The extent of such dilution will vary based upon the amount of capital raised.

Capital raising efforts through collaborations may eventually negatively impact our financial interests.

If we raise additional capital through collaborations and licensing we may give up valuable rights in intellectual property and the value of our interest in the licensed products could be negatively impacted by competing strategic
and financial interests of our collaborators or licensees. If we engage in collaborations, we may receive lower consideration upon commercialization of such products than if we had not entered into such arrangements, or if we had entered into such
arrangements at later stages in the product development process.



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We expect to continue to incur substantial losses in the foreseeable future. We do not now have, nor have we ever had,
products available for commercial sale and we may never generate revenues or become profitable.

To date, we have engaged primarily in
the research and development of drug candidates. We have not generated any revenues from product sales and have incurred losses in each year since our inception. As of December 31, 2005, we had an accumulated deficit of $239.5 million.

Our proposed products are in a relatively early developmental stage and will require significant research, development and testing. We
must obtain regulatory approvals for any proposed product prior to commercialization of the product. Our operations are also subject to various competitive and regulatory risks. As a result, we are unable to predict when or if we will achieve any
product revenues or become profitable. We expect to experience substantial losses in the foreseeable future as we continue our research, development and testing efforts.

Risks Related to Our Industry

Development and commercial introduction of our products will take several
more years and may not be successful.

We are dedicating substantially all of our resources to research and development, do not have any
marketed products and have not generated any product revenue. Because substantially all of our potential products currently are in research, preclinical development or the early and middle stages of clinical testing, revenues from sales of any
products will not occur for at least the next several years, if at all. Our technologies are relatively new fields and may not lead to commercially viable pharmaceutical products. Before we can commercially introduce any products, we will likely
incur substantial expense for, and devote a significant amount of time to, preclinical testing and clinical trials. We cannot apply for regulatory approval of our potential products until we have performed additional research and development testing
and demonstrated in preclinical testing and clinical trials that our product candidates are safe and effective for use in humans. Some of our product candidates are in the early stages of research and development and we may abandon further
development efforts on these product candidates before they reach clinical trials. Conducting clinical trials is a lengthy, time-consuming and expensive process. Our clinical trials may not demonstrate the safety and efficacy of our potential
products and we may encounter unacceptable side effects or other problems in the clinical trials. Should this occur, we may have to delay or discontinue development of the potential products. Further, even if we believe that a product is safe or
effective, we may not obtain the required regulatory approvals, be able to manufacture our products in commercial quantities or be able to market any product successfully.

Preclinical testing and clinical development are long, expensive and uncertain processes. It may take us several years to complete our testing and
failure can occur at any stage of testing. Success in preclinical testing and early clinical trials does not ensure that later clinical trials will be successful. We may suffer significant setbacks in advanced clinical trials, even after promising
results in earlier trials. We may not be able to enroll a sufficient number of patients to complete our clinical trials in a timely manner. Based on results at any stage of clinical trials, we may decide to discontinue development of our product
candidates.

Failure to recruit patients could delay or prevent clinical trials of our potential products, which could delay or prevent the development
of potential products.

Identifying and qualifying patients to participate in clinical trials of our potential products is critically
important to our success. The timing of our clinical trials depends on the speed at which we can recruit patients to participate in testing our product candidates. We have experienced delays in some of our clinical trials and we may experience
similar delays in the future. If patients are unwilling to participate in our trials because of competitive clinical trials for similar patient populations, the timeline for recruiting patients, conducting trials and obtaining regulatory approval of
potential products will be delayed. These delays could result in increased costs, delays in advancing our product development, delays in testing the effectiveness of our technology or termination of the clinical trials altogether.

Compliance with extensive government regulations to which we are subject is expensive and time consuming, and may result in the delay, cessation or cancellation of
product sales, introductions or modifications.

Extensive industry regulation has had, and will continue to have, a significant impact
on our business. Biopharmaceutical companies, like us, are subject to extensive, complex, costly and evolving regulation by the federal government, principally the FDA, and to a lesser extent by the U.S. Drug Enforcement Administration
(DEA) and foreign and state government agencies. The Federal Food, Drug and Cosmetic Act, the Controlled Substances Act and other domestic and foreign statutes and regulations govern or influence the testing, manufacturing, packing,
labeling, storing, record keeping, safety, approval, advertising, promotion, sale and distribution of our products. Under certain of these regulations, we and our contract suppliers and manufacturers could be subject to periodic inspection of our or
their respective facilities, procedures and operations and/or the testing of our products by the FDA, the DEA and other authorities, which conduct periodic inspections to confirm that we



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and our contract suppliers and manufacturers are in compliance with all applicable regulations. The FDA also conducts pre-approval and post-approval reviews
and plant inspections to determine whether our systems, or our contract suppliers and manufacturers processes, are in compliance with current Good Manufacturing Practices (cGMP) and other FDA regulations.

We are dependent on receiving and maintaining FDA and other governmental approvals in order to produce and conduct clinical trials on our products. There
is always a risk that the FDA or other applicable governmental authorities will not approve our products, or will take postapproval action limiting, modifying or revoking our ability to manufacture or sell our products, or that the rate,
timing and cost of such approvals will adversely affect our product introduction plans or results of operations.

Governmental authorities
may delay or deny the approval of any of our drug candidates. In addition, governmental authorities may enact new legislation or regulations that could limit or restrict our efforts. A delay or denial of regulatory approval for any of our drug
candidates will have a material adverse effect on our business. Even if we receive approval of a product candidate, approval may be conditioned upon certain limitations and restrictions as to the drugs used and may be subject to continuous review.
If we fail to comply with any applicable regulatory requirements, we could be subject to penalties, including warning letters, fines, withdrawal of regulatory approval, product recalls, operating restrictions, injunctions and criminal prosecution.

We expect to rely on third parties to market any products we develop and expect to rely on third parties in connection with the development of our
products; if these parties do not perform as expected, we may never successfully commercialize our products.

We do not have our own
sales and marketing staff. In order to successfully develop and market our future products, we must develop this infrastructure with inherent risks or enter into marketing and distribution arrangements with third parties. We also expect to delegate
the responsibility for all, or a significant portion, of the development and regulatory approval for certain products to third parties. If these parties do not develop an approvable or marketable product or do not market a product successfully, we
may never generate revenue or become profitable. Additionally, we may be unable to enter into successful arrangements with other parties for such products.

We currently have collaborative agreements with three primary collaborators: MedImmune, Inc., Ludwig Institute of Cancer Research (LICR) and Laboratorios Bago SA. We do not have control over the amount and
timing of resources to be devoted to our products by our collaborative partners. Our collaborators may not place a high priority on their contractual arrangements with us. Collaborators may develop products independently or through third parties
that could compete with our proposed products. In addition, a collaborator may decide to end a relationship with us.

We also may decide to
establish our own sales force to market and sell certain products. Although some members of our management have limited experience in marketing pharmaceutical products, we have no experience with respect to marketing our products. If we choose to
pursue this alternative, we will need to spend significant additional funds and devote significant management resources and time to establish a successful sales force. This effort may not be successful. Moreover, because our financial resources are
limited, our sales and marketing expenditures in this area would likely be modest compared to that of our competitors.

We face formidable competition
with respect to the products we are seeking to develop.

The pharmaceutical industry is characterized by intense competition. Many
companies, research institutions and universities are conducting research and development activities in our fields of interest. Most of these competitors have substantially greater financial, technical, manufacturing, marketing, distribution and
other resources than we have. We may also face competition from companies using different or advanced techniques that could render our future products obsolete. Accordingly, we must continue to devote substantial resources and efforts to research
and development activities in order to maintain a competitive position in our fields. Our efforts may not be successful.

Many companies
are working to develop and market products intended for additional disease areas being targeted by us, including age-related macular degeneration (AMD), cancer and respiratory diseases. A number of major pharmaceutical companies have
significant franchises in these disease areas and can be expected to invest heavily to protect their interests. With respect to AMD, anti-angiogenic agents are under development at a number of biopharmaceutical companies, including Alcon, Inc.,
Bausch & Lomb, Inc., Genentech, Inc., Miravant Medical Technologies, OSI Pharmaceuticals, Inc. and QLT, Inc., as well as other large pharmaceutical companies. For cancer, anti-angiogenic agents are under development at a number of
biopharmaceutical companies, including EntreMed, Inc., Genentech, Inc. and Imclone Systems, Inc., as well as other large pharmaceutical companies. In the respiratory field, other biopharmaceutical companies also have reported the discovery of genes
relating to asthma and other respiratory diseases, including Genentech, Inc., Amgen, Inc. and Vertex Pharmaceuticals, Inc., as well as other large pharmaceutical companies. Many of the companies developing or marketing competing products



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have significantly more experience than we do in undertaking preclinical testing and human clinical trials of new or improved therapeutic products and
obtaining regulatory approvals of such products. Some of these companies may be in advanced phases of clinical testing of various drugs that may be competitive with our proposed products.

We expect technological developments in the biopharmaceutical field to occur at a rapid rate and expect competition to intensify as advances in this
field are made. Some of these companies are currently involved in research and development activities focused on the pathogenesis of disease and the competition among companies attempting to find genes responsible for disease is intense. In
addition, we are aware that others are conducting research on compounds derived from animal host-defense systems.

Colleges, universities,
governmental agencies and other public and private research organizations are becoming more active in seeking patent protection and licensing arrangements to collect royalties for use of technology that they have developed, some of which may be
directly competitive with our technology.

If we are unable to recruit and retain skilled employees, we may not be able to achieve our objectives.

Retaining our current employees and recruiting qualified scientific personnel to perform future research and development work will be
critical to our success. In addition to pharmaceutical and specialized biotechnology companies, colleges, universities, governmental agencies and other public and private research organizations can be expected to compete with us in recruiting highly
qualified scientific personnel. Competition is intense for experienced scientists, and we may not be able to retain or recruit sufficient skilled personnel to allow us to pursue collaborations and develop our products and core technologies to the
extent otherwise possible.

If we do not develop and maintain relationships with contract manufacturers, we may not successfully commercialize our
products.

We currently do not have the resources, facilities or technical capabilities to manufacture any of our proposed products in
the quantities and quality required for commercial sale. We have no plans to establish a manufacturing facility. We expect to depend upon contract manufacturers for commercial scale manufacturing of our proposed products in accordance with
regulatory standards. For example, we are currently working with outside contractors for the chemical production of squalamine. This dependence on contract manufacturers may restrict our ability to develop and deliver products on a timely,
profitable and competitive basis especially because the number of companies capable of producing our proposed products is limited. These contract manufacturers generally have multiple projects and they may give ours a lower priority. As a result of
contract manufacturing mishaps, our product could be lost or delivered late, delaying our clinical and preclinical programs, or may not be produced in accordance with all current applicable regulatory standards. Product not produced in accordance
with all current applicable regulatory standards may lead to adverse outcomes for patients and/or product recalls. Furthermore, the development of a robust, low-cost manufacturing process for the commercial production of squalamine and other
proposed products will require significant time and expenditure by us. We may be unable to maintain arrangements with qualified outside contractors to manufacture materials at costs that are affordable to us, if at all.

Contract manufacturers may utilize their own technology, our technology or technology acquired or licensed from third parties in developing a
manufacturing process. In order to engage another manufacturer, we may need to obtain a license or other technology transfer from the original contract manufacturer. Even if a license is available from the original contract manufacturer on
acceptable terms, we may be unable to successfully effect the transfer of the technology to the new contract manufacturer. Any such technology transfer may also require the transfer of requisite data for regulatory purposes, including information
contained in a proprietary drug master file held by a contract manufacturer. If we rely on a contract manufacturer that owns the drug master file, our ability to change contract manufacturers may be more limited.

We depend on our intellectual property and, if we are unable to protect our intellectual property, our business may be harmed.

Patents

Our success depends, in part, on our ability
to develop and maintain a strong patent position for our products and technologies, both in the United States and other countries. As with most biotechnology and pharmaceutical companies, our patent position is highly uncertain and involves complex
legal and factual questions. Without patent and other protections, other companies could offer substantially identical products for sale without incurring the sizeable development and testing costs that we have incurred. As a result, our ability to
recover these expenditures and realize profits upon commercialization would likely be diminished.



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The process of obtaining patents can be time consuming and expensive. Even after significant expenditure,
a patent may not issue. We can never be certain that we were the first to develop the technology or that we were the first to file a patent application for the particular technology. U.S. patent applications are maintained in secrecy by the U.S.
Patent and Trademark Office until a patent issues and publications in the scientific or patent literature concerning new technologies occur some time after actual discoveries of the technologies are made.

We cannot be certain that:



| |  |  | patents will issue from any of our patent applications;
| | - |  | -------------------------------------------------------



| |  |  | our patent rights will be sufficient to protect our technology;
| | - |  | ---------------------------------------------------------------



| |  |  | others may not file patents ahead of us in time and prevent the issuing of our patent claims;
| | - |  | ---------------------------------------------------------------------------------------------



| |  |  | others will not design around the patented aspects of our technology; or
| | - |  | ------------------------------------------------------------------------



| |  |  | our patents will not be successfully challenged or circumvented by our competitors.
| | - |  | -----------------------------------------------------------------------------------

The cost of litigation related to patents can be substantial, regardless of the outcome.

We own several patents and patent applications for the use of squalamine as an anti-angiogenic, including methods for the treatment of cancer and
neovascularization in the eye. One of these patents is to the compounds combination therapy with other anti-cancer agents and will expire in 2017, while another patent covers the treatment of age-related macular degeneration, retinopathy of
prematurity and diabetic retinopathy and will expire in 2015. We also own patents covering methods and intermediates in the manufacturing process of squalamine and trodusquemine that expire in 2017, 2018 and 2021. We own a composition of matter
patent for the trodusquemine compound, which expires in 2014. We also own a patent for the use of trodusquemine as an anti-obesity agent and other indications that expires in 2015. We own two patents for the use of anti-IL9 or anti-IL9 receptor
antibodies for the treatment of asthma and related disorders that expire in 2016. We also have U.S. patents covering the composition of a matter for a mucoregulator target and another patent covering methods for screening for mucoregulator compounds
that both expire in 2019. We own a patent on the use of talniflumate and related mucoregulator compounds for treating various conditions where mucous is overproduced, which expires in 2021.

The expiration date of each of these patents is subject to extension depending upon the future research and development program timelines. We have filed
several other applications across our research and development programs and intend to file additional applications, as appropriate, for patents on new compounds, products or processes discovered or developed through the application of our
technology.

We have rights to several patents and patent applications under certain license agreements pursuant to which we expect to owe
royalties on sales of products that incorporate issued valid patent claims. In particular, we have licensed from the Ludwig Institute of Cancer Research specific technologies related to our IL9 program, the earliest of which expires in 2009. We have
licensed from the Childrens Hospital of Philadelphia the composition of matter patent for the squalamine compound, which expires in 2012. These patents are subject to extensions by their owners depending upon the future research and
development program timelines. Additionally, certain of these agreements also provide that if we elect not to pursue the commercial development of any licensed technology, or do not adhere to an acceptable schedule of commercialization, then our
exclusive rights to such technology may terminate.

Third Party Intellectual Property Rights

We cannot be sure that our products do not infringe on the intellectual property rights of others and we may have infringement claims asserted against us.
These claims may harm our reputation, cost us money and prevent us from offering some products. Any claims or litigation in this area may be costly and could result in large awards against us and, whether we ultimately win or lose, could be
time-consuming, may injure our reputation, may result in costly delays or may require us to enter into royalty or licensing arrangements. If there is a successful claim of infringement against us or if we fail to develop non-infringing technology or
license the proprietary rights on a timely basis, our ability to use certain technologies, products, services and brand names may be limited and our business may be harmed.

Other Intellectual Property

We have trademark protection for the product candidate names
EVIZON and LOMUCIN and are currently seeking U.S. registration of these trademarks. In order to protect our proprietary technology and processes, we also rely on trade secrets and confidentiality agreements with our employees,
consultants, outside scientific collaborators and other advisors. We may find that these agreements have been breached or that our trade secrets have otherwise become known or independently developed or discovered by our competitors.



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Certain of our exclusive rights to patents and patent applications are governed by contract. Generally,
these contracts require that we undertake certain obligations including the payment of royalties on sales of any products that are covered by patent claims. If we do not meet those obligations, we may lose our rights. Additionally, some of these
agreements also require that we develop the licensed technology or meet certain milestones within a given timeframe. If we do not adhere to an acceptable schedule of commercialization, we may lose our rights.

Potential Ownership Disputes

Disputes may arise as
to the ownership of our technology. Most of our research and development personnel have previously worked at other biotechnology companies, pharmaceutical companies, universities or research institutions. These entities may raise questions as to
when technology was developed and assert rights to the technology. These kinds of disputes have occurred in the past at our company and were resolved. However, we may not prevail in any such disputes in the future.

Similar technology ownership disputes may arise in the context of consultants, vendors or third parties, such as contract manufacturers. For example, our
consultants are employed by or have consulting agreements with third parties. There may be disputes as to the capacity in which consultants are operating when they make certain discoveries. We may not prevail in any such disputes.

If we cannot recruit and retain qualified management, we may not be able to successfully develop and commercialize our products.

We depend to a considerable degree on a limited number of key personnel. Most significant responsibilities have been assigned to a relatively small number
of individuals. In particular, it would be difficult to replace our President and Chief Executive Officer, John L. Armstrong, Jr. We entered into an evergreen employment agreement with Mr. Armstrong, dated October 21, 2003, that is
terminable by either party. This employment agreement contains non-competition and non-solicitation clauses. All of our executive officers have executed individual employment agreements with us. We do not maintain key man insurance on
any of our employees. The loss of certain management and technical personnel could adversely affect our ability to develop and commercialize products.

We are subject to potential product liability claims that could result in significant costs.

We are subject to significant
potential product liability risks inherent in the testing, manufacturing and marketing of human therapeutic products, including the risk that:



| |  |  | our proposed products cause some undesirable side effects or injury during clinical trials;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | our products cause undesirable side effects or injury in the market; or
| | - |  | -----------------------------------------------------------------------



| |  |  | third parties that we have agreed to indemnify incur a related liability.
| | - |  | -------------------------------------------------------------------------

We currently maintain primary products and completed operations liability insurance with per occurrence and aggregate coverage limits of $8.0 million. The coverage limits of our insurance policies may be inadequate to
fully protect us from liabilities we might incur in connection with clinical trials, manufacturing and marketing of our products. Product liability insurance is expensive and in the future may not be available on commercially acceptable terms, or at
all. A successful claim or claims brought against us in excess of our insurance coverage could materially harm our business and financial condition.

If
we do not receive adequate third-party reimbursement for any of our drug candidates, some patients may be unable to afford our products and sales could suffer.

In both the United States and elsewhere, the availability of reimbursement from third-party payers, such as government health administration authorities, private health insurers and other organizations, can impact
prescription pharmaceutical sales. These organizations are increasingly challenging the prices charged for medical products and services, particularly where they believe that there is only an incremental therapeutic benefit that does not justify the
additional cost. If any of our products ever obtain marketing approval, coverage and reimbursement may not be available for these products, or, if available, may not be adequate. Without insurance coverage, many patients may be unable to afford our
products, in which case sales of the products would be adversely affected.

There also has been a trend toward government reforms intended
to contain or reduce the cost of health care. In certain foreign markets, pricing or profitability of prescription pharmaceuticals is subject to government control. In the United States,



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there have been a number of federal and state proposals to implement similar government control. We expect this trend to continue, but we cannot predict the
nature or extent of any reform that results. These reforms could adversely affect our ability to obtain financing for the continued development of our proposed products or market any of our products that are successfully developed. Furthermore,
reforms could have a broader impact by limiting overall growth of health care spending, such as Medicare and Medicaid spending, which could also adversely affect our business.

Risks Related to Our Stock

Our stock price is extremely volatile and your investment in our stock could
decline in value. We may become involved in securities class action litigation.

The market prices and trading volumes for securities
of biopharmaceutical and biotechnology companies, including ours, have historically been, and will likely continue to be, highly volatile. Future events affecting our business, or that of our competitors, may have a significant impact on our stock
price. Among these events are the following:



| |  |  | product testing results from us or our competitors;
| | - |  | ---------------------------------------------------



| |  |  | technological innovations by us or our competitors;
| | - |  | ---------------------------------------------------



| |  |  | new commercial products from us or our competitors;
| | - |  | ---------------------------------------------------



| |  |  | whether and when we achieve specified development or commercialization milestones;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | regulatory developments in the United States and foreign countries;
| | - |  | -------------------------------------------------------------------



| |  |  | developments concerning proprietary rights, including patents;
| | - |  | --------------------------------------------------------------



| |  |  | regulatory actions;
| | - |  | -------------------



| |  |  | litigation;
| | - |  | -----------



| |  |  | economic and other external factors or other disasters or crises;
| | - |  | -----------------------------------------------------------------



| |  |  | period-to-period fluctuations in our financial results; and
| | - |  | -----------------------------------------------------------



| |  |  | the general performance of the equity markets and, in particular, the biotechnology sector of the equity markets.
| | - |  | -----------------------------------------------------------------------------------------------------------------

In the past two years our stock price on the Nasdaq SmallCap Market has fluctuated from a low of $1.28 per share on December 20, 2005 to a high of
$5.00 per share on January 27, 2004. In 2005, our stock price fluctuated from $1.28 to $3.50 per share, with an average price of approximately $2.09. The volatility in our stock price is due to the volatility of our industry in general and does
not appear to be connected to any event specific to us.

In the past, following periods of volatility in the market price of a particular
companys securities, securities class action litigation has often been brought against that company. We may become involved in this type of litigation in the future. Litigation of this type is often extremely expensive and diverts
managements attention and resources.

We may be unable to maintain the standards for listing on the Nasdaq SmallCap Market, which could adversely
affect the liquidity of our common stock and could subject our common stock to the penny stock rules.

Our common stock is
currently listed on the Nasdaq SmallCap Market. There are several requirements that we must satisfy in order for our common stock to continue to be listed on the Nasdaq SmallCap Market. These requirements include, but are not limited to, maintaining
a minimum per share price of our common stock of $1.00 and a minimum level of stockholders equity of $2.5 million. In the future, we may not comply with all of these listing requirements, which might result in the delisting of our common
stock. Delisting from the Nasdaq SmallCap Market could adversely affect the liquidity and the price of our common stock and could have a long-term adverse impact on our ability to raise future capital through a sale of our common stock.

If our common stock were delisted, our common stock would be traded on an electronic bulletin board established for securities that are not included
on Nasdaq, traded on a national securities exchange or traded in quotations published by the National Quotation Bureau, Inc., commonly referred to as the pink sheets. If this occurs, it could be difficult to sell our securities or obtain
the same level of market information as to the price of our common stock as is currently available.

In addition, if our common stock were
delisted, it would be subject to the so-called penny stock rules. The SEC has adopted regulations that define a penny stock to be any equity security that has a market price per share of less than $5.00, subject to certain
exceptions, such as any securities listed on a national securities exchange or quoted on Nasdaq. For any transaction involving a penny stock, unless exempt, the rules impose additional sales practice requirements on broker-dealers,
subject to certain exceptions.



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##### Table of Contents

For transactions covered by the penny stock rules, a broker-dealer must make a special
suitability determination for the purchaser and must have received the purchasers written consent to the transaction prior to the transaction. The penny stock rules also require broker-dealers to deliver monthly statements to
penny stock investors disclosing recent price information for the penny stock held in the account and information on the limited market in penny stocks. Prior to the transaction, a broker-dealer must provide a
disclosure schedule relating to the penny stock market. In addition, the broker-dealer must disclose the following:



| |  |  | commissions payable to the broker-dealer and the registered representative; and
| | - |  | -------------------------------------------------------------------------------



| |  |  | current quotations for the security as mandated by the applicable regulations.
| | - |  | ------------------------------------------------------------------------------

If our common stock were delisted and determined to be a penny stock, a broker-dealer may find it more difficult to trade our common stock and an investor may find it more difficult to acquire or dispose
of our common stock in the secondary market.

The exercise of options and warrants and other issuances of shares will likely have a dilutive effect on
our stock price.

As of December 31, 2005, there were outstanding options to purchase an aggregate of 5,577,250 shares of our
common stock at prices ranging from $0.40 per share to $11.63 per share, of which options to purchase 2,275,187 shares were exercisable as of such date. As of December 31, 2005, there were outstanding warrants to purchase 4,627,266 shares of
our common stock. Of this total, warrants to purchase 167,166 shares of our common stock are currently exercisable at $3.33 per share, subject to adjustment under the anti-dilution provisions of the warrants. Warrants to purchase 50,000 and 990,100
shares are currently exercisable at $3.79 and $5.38 per share, respectively. In September 2005, in connection with a registered direct offering of our common stock, we issued to institutional investors warrants to purchase 3,420,000 shares of our
common stock at an exercise price of $3.15 per share, which are exercisable as of March 13, 2006. In connection with an April 2002 private placement of our common stock, we granted to the placement agent warrants to purchase 100,000 shares of
our common stock at an exercise price of $2.75 per share. As of December 31, 2005, these warrants have not yet been issued.

The
exercise of options and warrants at prices below the market price of our common stock could adversely affect the price of our common stock. Additional dilution may result from the issuance of shares of our capital stock in connection with
collaborations or manufacturing arrangements or in connection with other financing efforts.

Our certificate of incorporation and Delaware law contain
provisions that could discourage a takeover and entrench management.

Our certificate of incorporation provides our board of directors
the power to issue shares of preferred stock without stockholder approval. This preferred stock could have voting rights, including voting rights that could be superior to that of our common stock. In addition, Section 203 of the Delaware
General Corporation Law contains provisions that impose restrictions on stockholder action to acquire control of us. The effect of these provisions of our certificate of incorporation and Delaware law make it more difficult to remove management and
could discourage third parties from seeking to obtain control, even though the price at which such third parties seek to acquire our common stock is in excess of the market price for our stock.



|ITEM 1B. | UNRESOLVED STAFF COMMENTS
|-------- | -------------------------

None.



|ITEM 2. | PROPERTIES
|------- | ----------

We lease approximately 21,000 square
feet of office and laboratory space in a single building in Plymouth Meeting, Pennsylvania. This lease provides for minimum annual payments of approximately $0.4 million in 2006 and is subject to certain annual increases thereafter. This lease
expires in November 2007.



|ITEM 3. | LEGAL PROCEEDINGS
|------- | -----------------

On August 4, 2003, a
lawsuit was filed against the Company by Perceptive Life Sciences Master Fund, LTD in the United States District Court for the Eastern District of Pennsylvania alleging the existence and subsequent breaches of certain contractual obligations by the
Company in connection with its sale of shares of Series C Preferred Stock in May 2003. The plaintiff was seeking monetary damages from the Company or a judgment by the court that the Company should specifically perform the terms of an alleged
agreement related to such sale. On February 2, 2005, the parties entered into a settlement agreement. The settlement is on terms that are not material to the Company and does not constitute an admission of wrongdoing or liability by the
Company. On February 28, 2005, the Court entered the parties stipulated order dismissing the lawsuit with prejudice.



15



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##### Table of Contents

|ITEM 4. | SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
|------- | ---------------------------------------------------

No matters were submitted to a vote of our stockholders during the last quarter of the year ended December 31, 2005.



16



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##### Table of Contents

PART II



|ITEM 5. | MARKET FOR REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
|------- | ------------------------------------------------------------------------------------------------------------

Our common stock currently trades on the National Association of Securities Dealers Automated Quotation System (Nasdaq) SmallCap Market under the symbol
GENR. From December 12, 1991, the date of our initial public offering, until March 9, 2001 our common stock was included for quotation on the Nasdaq National Market under the symbol MAGN. On March 9, 2001, we
changed our name to Genaera Corporation and on March 12, 2001, our common stock began inclusion for quotation on the Nasdaq National Market under the symbol GENR. Our common stock was included for quotation under the Nasdaq National
Market through October 30, 2002, when we elected to begin trading on the Nasdaq SmallCap Market effective with the opening of trading on October 31, 2002.

The quarterly ranges of high and low closing bid prices per share of our common stock are shown below.



|                             |  |      |      |     |   |     
|---------------------------- |  | ---- | ---- | --- | - | ----
|Year Ended December 31, 2004 |  | High |      | Low
|1st Quarter                  |  | $    | 5.00 |     | $ | 3.45
|2nd Quarter                  |  | $    | 4.80 |     | $ | 3.26
|3rd Quarter                  |  | $    | 4.19 |     | $ | 2.75
|4th Quarter                  |  | $    | 4.22 |     | $ | 3.01
|                             |  |     
|Year Ended December 31, 2005 |  | High |      | Low
|1st Quarter                  |  | $    | 3.50 |     | $ | 2.28
|2nd Quarter                  |  | $    | 2.31 |     | $ | 1.57
|3rd Quarter                  |  | $    | 2.67 |     | $ | 1.45
|4th Quarter                  |  | $    | 1.88 |     | $ | 1.28

As of March 1, 2006, the last reported bid price for our common stock on the Nasdaq SmallCap
Market was $1.65 per share.

Dividends

We have not paid any cash dividends on our common stock since our inception and we do not anticipate paying any cash dividends on our common stock in the foreseeable future. It is the present policy of the board of
directors to retain all earnings, if any, to finance the development of our business.

Number of Holders of Common Stock

At February 10, 2006, there were 344 stockholders of record and 16,062 beneficial owners of our common stock.



17



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##### Table of Contents

Equity Compensation Plan Information

The following table provides aggregate information, as of December 31, 2005, regarding our equity compensation plans, including the 2004 Stock-Based
Incentive Compensation Plan, the Amended 1998 Equity Compensation Plan and the 1992 Stock Option Plan (the 1992 Plan). As a result of the expiration of the 1992 Plan in 2002, no additional option grants will be made under the 1992 Plan.



|                                                           |  |                                                                                                                                 |  |                                                                    |      |                                                                                                                                            |          
|---------------------------------------------------------- |  | ------------------------------------------------------------------------------------------------------------------------------- |  | ------------------------------------------------------------------ | ---- | ------------------------------------------------------------------------------------------------------------------------------------------ | ---------
|                                                           |  | (a)                                                                                                                             |  | (b)                                                                |      | (c)                                                                                                                                       
|                                                           |  | Number of securities to be issued upon exercise of outstanding options and rights and lapse of restrictions on restricted stock |  | Weighted-average exercise price of outstanding options and rights1 |      | Number of securities remainingavailable for future issuances under equity compensation plans (excluding securities reflected incolumn
(a))
|Equity compensation plans approved by security holders     |  | 5,763,916                                                                                                                       |  | $                                                                  | 2.90 |                                                                                                                                            | 1,698,625
|Equity compensation plans not approved by security holders |  |                                                                                                                                |  |                                                                    |     |                                                                                                                                            |         
|                                                           |  |                                                                                                                                 | 
|                                                           |  |                                                                                                                                 |  |                                                                    |      |                                                                                                                                            |          
|Total                                                      |  | 5,763,916                                                                                                                       |  | $                                                                  | 2.90 |                                                                                                                                            | 1,698,625
|                                                           |  |                                                                                                                                 |  |                                                                    |      |                                                                                                                                            |          



|1 | Does not include restricted stock as exercise price is determined on date of issuance, not
date of grant.
|- | ---------------------------------------------------------------------------------------------------------

See ITEM 8. Financial Statements and Supplementary Data and NOTE 10. Common Stock Options
and Restricted Common Stock Awards for additional information regarding the Companys equity compensation plans.



18



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##### Table of Contents

|ITEM 6. | SELECTED FINANCIAL DATA
|------- | -----------------------

The following tables
summarize certain selected financial data and are derived from our audited financial statements. The selected financial data below should be read in conjunction with our financial statements and notes thereto, Managements Discussion and
Analysis of Financial Condition and Results of Operations and the other financial information included herein.



|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|------------------------------------------------------------------------------------------------------ |  | ---------------------------------------- | -------- | - | ---- | - | -------- | ---- |  | - | -------- | - |  | ---- | -------- | - |  | - | -------- | -
|                                                                                                       |  | Year Ended December 31,                  |         
|                                                                                                       |  | 2005                                     |          |   | 2004 |   |          | 2003 |  |   | 2002     |   |  | 2001 |         
|                                                                                                       |  | (In thousands, except per share amounts) |         
|Statement of Operations Data:                                                                          |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Revenues:                                                                                              |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Collaborative research agreement and grant revenues                                                    |  | $                                        | 446      |   |      | $ | 873      |      |  | $ | 1,113    |   |  | $    | 1,517    |   |  | $ | 1,038    |  
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Costs and expenses:                                                                                    |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Research and development                                                                               |  |                                          | 21,792   |   |      |   | 14,004   |      |  |   | 7,922    |   |  |      | 10,216   |   |  |   | 11,019   |  
|General and administrative                                                                             |  |                                          | 5,891    |   |      |   | 4,951    |      |  |   | 2,864    |   |  |      | 3,560    |   |  |   | 3,536    |  
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|                                                                                                       |  |                                          | 27,683   |   |      |   | 18,955   |      |  |   | 10,786   |   |  |      | 13,776   |   |  |   | 14,555   |  
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Loss from operations                                                                                   |  |                                          | (27,237  | ) |      |   | (18,082  | )    |  |   | (9,673   | ) |  |      | (12,259  | ) |  |   | (13,517  | )
|Interest income, net                                                                                   |  |                                          | 870      |   |      |   | 327      |      |  |   | 23       |   |  |      | 103      |   |  |   | 605      |  
|Gain (loss) on sale of fixed assets                                                                    |  |                                          | 6        |   |      |   | (118     | )    |  |   | 257      |   |  |      |         |   |  |   |         |  
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Net loss                                                                                               |  |                                          | (26,361  | ) |      |   | (17,873  | )    |  |   | (9,393   | ) |  |      | (12,156  | ) |  |   | (12,912  | )
|Dividends on preferred stock, including $3,050 attributable to a beneficial conversion feature in 2003 |  |                                          |         |   |      |   |         |      |  |   | (3,085   | ) |  |      | (73      | ) |  |   | (111     | )
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Net loss                                                                                               |  | $                                        | (26,361  | ) |      | $ | (17,873  | )    |  | $ | (12,478  | ) |  | $    | (12,229  | ) |  | $ | (13,023  | )
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Net loss per share-basic and diluted                                                                   |  | $                                        | (0.44    | ) |      | $ | (0.34    | )    |  | $ | (0.32    | ) |  | $    | (0.35    | ) |  | $ | (0.40    | )
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Weighted average shares outstanding-basic and diluted                                                  |  |                                          | 60,580   |   |      |   | 52,839   |      |  |   | 38,634   |   |  |      | 34,894   |   |  |   | 32,711   |  
|                                                                                                       |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|                                                                                                       | 
|                                                                                                       |  | December 31,                             |         
|                                                                                                       |  | 2005                                     |          |   | 2004 |   |          | 2003 |  |   | 2002     |   |  | 2001 |         
|                                                                                                       |  | (In thousands)                           |         
|Balance Sheet Data:                                                                                    |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Cash, cash equivalents and short-term investments                                                      |  | $                                        | 32,215   |   |      | $ | 32,151   |      |  | $ | 13,135   |   |  | $    | 9,400    |   |  | $ | 16,078   |  
|Total assets                                                                                           |  |                                          | 34,011   |   |      |   | 33,548   |      |  |   | 14,553   |   |  |      | 11,191   |   |  |   | 17,816   |  
|Long-term liabilities                                                                                  |  |                                          | 1,781    |   |      |   | 580      |      |  |   | 1,048    |   |  |      | 1,704    |   |  |   | 1,579    |  
|Redeemable convertible preferred stock                                                                 |  |                                          |         |   |      |   |         |      |  |   |         |   |  |      | 1,117    |   |  |   | 1,044    |  
|Accumulated deficit                                                                                    |  |                                          | (239,532 | ) |      |   | (213,171 | )    |  |   | (195,298 | ) |  |      | (182,819 | ) |  |   | (170,591 | )
|Stockholders equity                                                                                   |  |                                          | 26,284   |   |      |   | 29,082   |      |  |   | 10,622   |   |  |      | 4,511    |   |  |   | 9,610    |  
|Other Data:                                                                                            |  |                                          |          |   |      |   |          |      |  |   |          |   |  |      |          |   |  |   |          |  
|Working capital                                                                                        |  |                                          | 27,161   |   |      |   | 28,867   |      |  |   | 10,516   |   |  |      | 5,727    |   |  |   | 10,713   |  



19



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##### Table of Contents

|ITEM 7. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

OVERVIEW

Genaera Corporation is a biopharmaceutical company committed to developing medicines for
serious diseases from genomics and natural products. Research and development efforts are focused on anti-angiogenesis and respiratory diseases. We have four products in development addressing substantial unmet medical needs in major pharmaceutical
markets.

Since commencing operations in 1988, we have not generated any revenue from product sales. We have funded operations primarily
from the proceeds of public and private placements of securities, research and development collaboration payments and related equity investments. We have incurred a loss in each year since our inception and we expect to incur substantial additional
losses for at least the next several years. We expect that losses may fluctuate and that such fluctuations may be substantial. At December 31, 2005, our accumulated deficit was $239.5 million. We will need to raise additional funds in the
future to continue our operations.

The following discussion is included to describe our financial position and results of operations for
each of the previous three years in the period ended December 31, 2005. The Financial Statements and Notes thereto contain detailed information that should be referred to in conjunction with this discussion.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

The
preparation of our financial statements in conformity with U.S. generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in our financial statements and accompanying notes.
Actual results could differ materially from those estimates. The following are critical accounting policies important to our financial condition and results of operations that require management to make judgments, assumptions and estimates that are
inherently uncertain.

Revenue Recognition

Contract revenue for research and development is recorded as earned based on the performance requirements of the contract. Non-refundable contract fees for which no further performance obligations exist, and for which
there is no continuing involvement by us, are recognized at the earlier of when the payments are received or when collection is assured. Revenue from non-refundable upfront license fees and certain guaranteed payments where we continue involvement
through development collaboration is recognized on a straight-line basis over the development period. Revenue associated with performance milestones is recognized based upon the achievement of the milestones, as defined in the respective agreements.
Revenue under research and development cost reimbursement contracts is recognized as the related costs are incurred. Advance payments received in excess of amounts earned are classified as liabilities until earned. Payments received that are
refundable also are classified as liabilities until the refund provision expires. We make an estimate as to the appropriate deferral period for recognition of revenue on any collaborative fees received. Changes in these estimates, due to the
evolution of the development program, can have a significant effect on the timing of when revenue is recorded.

Research and Development
Expenses

Research and development expenses include related salaries, contractor fees and facility costs. Research and development
expenses consist of independent research and development contract costs, contract manufacturing costs and costs associated with collaborative research and development arrangements. In addition, we fund research and development at other research
institutions under agreements that are generally cancelable. Research and development expenses also include external activities, such as investigator-sponsored trials. All such costs are charged to research and development expense systematically as
incurred, which may be measured by patient enrollment or the passage of time. At the initiation of certain contracts, we must make an estimate as to the duration and expected completion date of the contract, which may require a change due to
accelerations, delays or other adjustments to the contract period or work performed. Changes in these estimates could have a significant effect on the amount of research and development costs in a specific period.

Stock-Based Compensation

We account
for stock-based employee compensation under the intrinsic-value-based method set forth by Accounting Principles Board (APB) Opinion No. 25, Accounting for Stock Issued to Employees, and related interpretations. Effective
January 1, 1996, we adopted the disclosure-only provisions of Statement of Financial Accounting Standards (SFAS) No. 123,



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##### Table of Contents

Accounting for Stock-Based Compensation (SFAS 123). Stock or other equity-based compensation for non-employees must be accounted for under the
fair-value-based method as required by SFAS 123 and Emerging Issues Task Force (EITF) No. 96-18, Accounting for Equity Instruments that are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling, Goods or
Services, and other related interpretations. Under this method, the equity-based instrument is valued at the fair value of either the consideration received or the equity instrument issued. The resulting compensation cost is recognized and charged
to operations over the service period, which is usually the vesting period. Estimating the fair value of equity securities involves a number of judgments and variables that are subject to significant change.

On December 16, 2004, the Financial Accounting Standards Board published SFAS No. 123 (Revised 2004), Share-Based Payment (SFAS
123R). SFAS 123R requires that compensation cost related to share-based payment transactions be recognized in the financial statements. Share-based payment transactions within the scope of SFAS 123R include stock options, restricted stock
plans, performance-based awards, stock appreciation rights and employee share purchase plans. The provisions of SFAS 123R are effective as of the first annual period that begins after June 15, 2005. Accordingly, the Company will implement the
revised standard in the first quarter of fiscal year 2006. The implications of this revised standard will materially impact the Companys results of operations in the first quarter of fiscal year 2006 and thereafter.

RESULTS OF OPERATIONS  2005 vs. 2004

Revenues

We have received no revenues to date from product sales. Revenues recorded to date have consisted principally of
revenues recognized under collaborations with third parties. In April 2001, we entered into a research collaboration and licensing agreement with MedImmune, Inc., to develop and commercialize therapies related to our IL9 program. MedImmune provided
funding of $2.5 million, payable in eight equal quarterly installments through April 2003 (the R&D Funding). plus it funds external cost reimbursements for our research and development activities. We could also receive up to $54.5
million of additional funding based on successful completion of future milestones. In August 2004, we received the first of such milestone payments as a result of the initiation of Phase I clinical trials. For the year ended December 31, 2005,
we recognized $0.3 million as revenue related to external cost reimbursements. For the year ended December 31, 2004, we recognized $0.8 million as revenue related to external cost reimbursements ($0.3 million) and milestone payments ($0.5
million).

In February 2002, the Company received a Phase II Small Business Innovative Research program grant from the NIH in the amount of
$0.8 million to support its aminosterol research program. The grant extended over a two-year period, which ended in February 2004. In February 2004, the Company notified the NIH of a no-cost extension of the original budget period by twelve months.
As a result of the notification, the grant was extended through February 2005. The Company recognized $0.1 million as revenue related to this grant in the year ended December 31, 2005. The Company recognized no revenue related to this grant for
the year ended December 31, 2004.

Research and Development Expenses

Our current research and development programs include squalamine (squalamine lactate), which consists of EVIZON for the treatment of AMD and
squalamine for the treatment of cancer, LOMUCIN, IL9 and other programs, which consist of trodusquemine for the treatment of obesity, other aminosterols for the treatment of inflammatory disorders and LOCILEX Cream for the treatment of
infectious disease. The following table illustrates our research and development projects and the stage to which each has been developed:



|                     |  |                      |  |                
|-------------------- |  | -------------------- |  | ---------------
|                     |  | Development Stage    |  | Status         
|Squalamine:          |  |                      |  |                
|EVIZON (Squalamine) |  | Phase II/III(1)      |  | Active         
|Squalamine           |  | Phase II             |  | Active         
|LOMUCIN             |  | Phase II             |  | Active         
|IL9 program          |  | Phase I              |  | Active(2)      
|Other programs:      |  |                      |  |                
|Trodusquemine        |  | Research/Preclinical |  | Active/Inactive
|Other Aminosterols   |  | Research             |  | Active         
|LOCILEX Cream        |  | Phase III            |  | Inactive       



|(1) | In June 2005, we began the first of two planned Phase III trials of EVIZON for the treatment of age-related macular degeneration.
|--- | ---------------------------------------------------------------------------------------------------------------------------------



|(2) | In April 2001, we entered into a collaborative agreement with MedImmune to develop and commercialize therapies related to our IL9 program.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------



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Research and development expenses for each of our projects consist of both direct and indirect expenses.
Direct expenses include salaries and other costs of personnel, raw materials and supplies for each project. We also may incur third-party costs related to these projects, such as contract research, clinical development and manufacturing costs and
consulting costs. Indirect expenses include depreciation expense and the costs of operating and maintaining our facilities, property and equipment, to the extent used for our research and development projects, as well as the costs of general
management of our research and development projects.

We recognized research and development expenses of $21.8 million and
$14.0 million in 2005 and 2004, respectively. The following table illustrates research and development expenses (in thousands) incurred during the years ended December 31, 2005 and 2004 for our significant groups of research and
development projects.



|                            |  |                          |        |      |   |       
|--------------------------- |  | ------------------------ | ------ | ---- | - | ------
|                            |  | Years ended December 31,
|                            |  | 2005                     |        | 2004
|Squalamine program expenses |  | $                        | 17,183 |      | $ | 10,097
|LOMUCIN program expenses   |  |                          | 1,119  |      |   | 545   
|IL9 program expenses        |  |                          | 264    |      |   | 241   
|Other program expenses      |  |                          | 121    |      |   | 267   
|Indirect expenses           |  |                          | 3,105  |      |   | 2,854 
|                            |  |                          |        |      |   |       
|                            |  | $                        | 21,792 |      | $ | 14,004
|                            |  |                          |        |      |   |       

Research and development expenses increased in the year ended December 31, 2005, as compared
to the same period a year ago, due to increases in clinical trial costs ($8.5 million), personnel costs ($0.4 million) and costs for research and development supplies ($0.2 million) related to our squalamine program for the treatment of age-related
macular degeneration, as well as increases in clinical trial costs ($0.7 million) related to our LOMUCINTMprogram.
In addition, indirect expenses increased ($0.2 million) as a result of increased overhead, such as utilities, insurance and general facilities costs related to additional personnel. These increases were partially offset by decreases in third-party
contract research ($1.5 million), manufacturing ($0.2 million) and consulting expenses ($0.2 million) related to our squalamine program for the treatment of age-related macular degeneration, decreases in manufacturing expenses ($0.1 million) related
to our LOMUCINTMprogram, as well as decreases in other program expenses ($0.1 million).

The costs incurred to date on each of our development projects are not reasonably estimable because work on one program often supports or enhances
another program. For example, it is not possible to separate the time and resources spent in development of squalamine lactate as a product candidate to treat wet AMD and as a product candidate to treat cancer because: (i) early research and
development efforts devoted to cancer research led to development of Genaeras product candidate squalamine lactate (trade name EVIZONTM) for AMD; (ii) clinical trial work pursuant to Genaeras Investigational New Drug (IND) application for cancer forms part of the safety data base for the IND it filed with the FDA for wet AMD;
(iii) Genaeras manufacturing development for squalamine lactate supports both the AMD and cancer programs; and (iv) nonclinical testing conducted supports all regulatory filings and proposed indications for squalamine.

The level of research and development expenses in future periods will depend principally upon the progress of our research and development programs and
our capital resources. Due to the significant risks and uncertainties inherent in the preclinical and clinical studies associated with each of our research and development programs, the cost to complete such programs, as well as the period in which
net cash inflows from significant programs are expected to commence, are not reasonably estimable. Preclinical and clinical studies may yield varying results that could delay, limit or prevent a programs advancement through the various stages
of product development and significantly impact the costs to be incurred and the time involved in bringing a program to completion. Such delays, limitations or prevention of a programs advancement could harm our financial condition and
operating results and inhibit our ability to raise additional funds to support ongoing operations.

The nature of costs incurred in the
future will also vary depending upon the stage of the product candidates development. Product candidates in the research stage often require significant laboratory work to develop and prepare the product candidate for preclinical testing and
for testing in humans. Costs for such work typically include Genaera staff, Genaera facilities, lab supplies and equipment and fees to contract research facilities supervised by Genaera personnel. All products to be tested in humans require
preclinical testing and often require additional nonclinical testing while clinical trials are in process to fulfill regulatory requirements. Preclinical and nonclinical work requires expenditures for staffing and facilities at Genaera. Costs will
also be incurred for work done by contract research facilities under Genaera supervision. Early stage products require development of manufacturing methods, supporting analytical and research work and qualifying vendors, including contract
manufacturers. Products in human testing, particularly later stage trials, require manufacturing more significant quantities of product. The costs of conducting clinical trials include fees to contract research organizations to conduct the trials,
payments to physicians and research centers, and payments for a wide range of services to prepare for clinical trials, support the trials and



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manage data gathered in the trials. Internal Genaera costs for clinical trials include staffing and infrastructure to design, adapt and manage the trials, as
well as managing vendors providing supporting services. Smaller but continuing costs throughout the clinical trials process also include quality control and regulatory compliance activities conducted by Genaera staff and through contractors
supervised by Genaera.

General and Administrative Expenses

We recognized general and administrative expenses of $5.9 million and $5.0 million in 2005 and 2004, respectively. General and administrative
expenses consist principally of personnel costs, professional fees and public company expenses. General and administrative costs increased in the year ended December 31, 2005, as compared to the same period a year ago, due principally to
increases in personnel as a result of our expanded development efforts ($0.7 million), payment related to the resignation of the Companys prior Chief Executive Officer ($0.6 million) and increased consulting expenses ($0.1 million). These
increases were partially offset by decreases in patent filing fees ($0.4 million), and decreased investor relations expenses ($0.1 million).

Interest Income and Other

We recognized interest income of $0.9 million and $0.3 million in 2005 and 2004,
respectively. Interest income is primarily comprised of income generated from cash and investments. Interest income increased during the year ended December 31, 2005, as compared to the same period a year ago, due to higher average investment
balances and increasing interest rates. We recognized a loss on the write-off of fixed assets of $0.1 million for the year ended December 31, 2004 as a result of the sale of excess research equipment.

RESULTS OF OPERATIONS  2004 vs. 2003

Revenues

In April 2001, we entered into a research collaboration and licensing agreement with MedImmune, Inc., to develop
and commercialize therapies related to our IL9 program. MedImmune provided funding of $2.5 million, payable in eight equal quarterly installments through April 2003, plus funds external cost reimbursements for our research and development
activities. For the year ended December 31, 2004, we recognized $0.8 million as revenue related to external cost reimbursements ($0.3 million) and milestone payments ($0.5 million). For the year ended December 31, 2003, we recognized $0.7
million as revenue related to the R&D Funding ($0.4 million) and external cost reimbursements ($0.3 million).

In February 2002, the
Company received a Phase II Small Business Innovative Research program grant from the NIH in the amount of $0.8 million to support its aminosterol research program. The grant extended over a two-year period, which ended in February 2004 and was
subsequently extended through February 2005. The Company recognized no revenue related to this grant for the year ended December 31, 2004. The Company recognized $0.4 million as revenue related to this grant in the year ended December 31,
2003.

Research and Development Expenses

We recognized research and development expenses of $14.0 million and $7.9 million in 2004 and 2003, respectively. The following table illustrates research and development expenses (in thousands) incurred during
the years ended December 31, 2004 and 2003 for our significant groups of research and development projects.



|                            |  |                          |        |      |   |      
|--------------------------- |  | ------------------------ | ------ | ---- | - | -----
|                            |  | Years ended December 31,
|                            |  | 2004                     |        | 2003
|Squalamine program expenses |  | $                        | 10,097 |      | $ | 4,254
|LOMUCIN program expenses   |  |                          | 545    |      |   | 944  
|IL9 program expenses        |  |                          | 241    |      |   | 426  
|Other program expenses      |  |                          | 267    |      |   | 238  
|Indirect expenses           |  |                          | 2,854  |      |   | 2,060
|                            |  |                          |        |      |   |      
|                            |  | $                        | 14,004 |      | $ | 7,922
|                            |  |                          |        |      |   |      

Research and development expenses increased in the year ended December 31, 2004, as compared
to the year ended December 31, 2003, due primarily to increases in third-party contract research ($1.5 million), manufacturing ($1.7 million) and clinical trial costs ($0.7 million) and an increase in costs for research and development supplies
($0.2 million) related to our



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squalamine program for the treatment of age-related macular degeneration, as well as resulting increases in personnel costs ($2.2 million). In addition,
indirect expenses increased ($0.8 million) as a result of increased overhead, such as utilities, insurance and general facilities costs related to additional personnel and increased research, clinical and manufacturing efforts. These increases were
partially offset by decreases in our LOMUCINTM($0.4 million) and IL9 program ($0.2 million) expenses due to the
conclusion of our Phase II clinical trial of LOMUCIN in patients with cystic fibrosis in 2003 and the transfer of responsibility for development and commercialization efforts on the IL9 program to MedImmune in April of 2003, as well as a
decrease in consulting costs ($0.4 million) related to our squalamine program for the treatment of age-related macular degeneration.

General and Administrative Expenses

We recognized general and administrative expenses of $5.0 million and
$2.9 million in 2004 and 2003, respectively. General and administrative expenses consist principally of personnel costs, professional fees and public company expenses. General and administrative costs increased in the year ended
December 31, 2004, as compared to the year ended December 31, 2003, due principally to increases in personnel as a result of our expanded development efforts ($1.2 million), increased professional fees ($0.8 million), partially due to
maintaining compliance with the Sarbanes-Oxley Act of 2002, and increases in investor relations expenses ($0.2 million).

Interest
Income, Interest Expense and Other

We recognized interest income of $0.3 million and $88 thousand in 2004 and 2003, respectively.
Interest income is primarily comprised of income generated from cash and investments. Interest income increased during the year ended December 31, 2004 as compared to the year ended December 31, 2003, due to higher average investment
balances. We recognized interest expense of $2 thousand and $65 thousand in 2004 and 2003, respectively. Interest expense was primarily comprised of expense related to our indebtedness to Merrill Lynch Bank USA (Merrill Lynch). Interest expense
decreased during the year ended December 31, 2004, as compared to the prior year, due to the repayment of our indebtedness to Merrill Lynch. (See NOTE 6. Note Payable for additional information.) We recognized a loss on the
write-off of fixed assets of $0.1 million for the year ended December 31, 2004 and a gain on the sale of fixed assets of $0.3 million in the year ended December 31, 2003 as a result of the sale of excess research equipment.

LIQUIDITY AND CAPITAL RESOURCES

Cash, cash
equivalents and short-term investments were $32.2 million at December 31, 2005 as compared to $32.2 million at December 31, 2004. The primary use of cash was to finance our research and development operations. The use of cash was offset by
the net proceeds of $22.9 million from our sale of 11,400,000 shares of common stock in September 2005.

Since inception, we have funded
our operations primarily from the proceeds of public and private placements of our securities totaling approximately $230.1 million since our initial public offering in December 1991 and including the proceeds from the following private placements
of our securities, net of costs, in 2003, 2004 and 2005:



| |  |  | $ 4.9 million  May 2003;
| | - |  | -------------------------



| |  |  | $ 7.9 million  November 2003;
| | - |  | ------------------------------



| |  |  | $ 19.9 million  January 2004;
| | - |  | ------------------------------



| |  |  | $ 13.5 million  November 2004: and
| | - |  | -----------------------------------



| |  |  | $ 22.9 million  September 2005.
| | - |  | --------------------------------

In addition
to the above, we have funded our operations from contract and grant revenues, research and development expense reimbursements, interest income, lease financing and debt financing.

Our goal is to conduct significant research, pre-clinical development, clinical testing and manufacturing activities over the next several years. We
expect that these activities, together with projected general and administrative expenses, will result in continued and significant losses.

Current liabilities increased by $2.0 million from $3.9 million at December 31, 2004 to $5.9 million at December 31, 2005, due primarily to an increase in accounts payable and accrued expenses resulting from the timing and
magnitude of our current development contracts. Prior to 1999, we had an agreement with Abbott Laboratories (Abbott) providing for the purchase of approximately $10.0 million of bulk drug substance for LOCILEX Cream. As FDA approval of LOCILEX Cream
did not occur, we renegotiated this agreement with Abbott in 1999, paying Abbott $4.2 million and receiving partial delivery of material. An additional $3.4 million was due to Abbott and payable if we receive in excess of $10.0 million of additional
funds in any year beginning in 2000, in which case 15% of such excess over $10.0 million shall be payable to Abbott. We have no further



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purchase commitments to Abbott and Abbott has no further supply requirements to us. As a result of the Companys financing activities during 2000 and
2001 and other cash inflows, $1.4 million and $0.5 million of this liability was payable and paid to Abbott on March 1, 2001 and 2002, respectively. No portion of the liability was payable to Abbott on March 1, 2003 as the Company did not
receive in excess of $10.0 million of cash inflows during 2002. As a result of the Companys financing activities during 2003 and other cash inflows, $1.0 million of the remaining liability was payable and paid to Abbott on March 1, 2004.
The remaining liability of $0.6 million was payable and paid to Abbott on March 1, 2005 as a result of the Companys financing activities during the year ended December 31, 2004.

Our capital expenditure requirements will depend upon numerous factors, including the progress of our research and development programs, the time and
cost required to obtain regulatory approvals, our ability to enter into additional collaborative arrangements, the demand for products based on our technology, if and when such products are approved, and possible acquisitions of products,
technologies and companies. We had no significant capital commitments as of December 31, 2005.

We regularly explore alternative means
of financing our operations and seek funding through various sources, including public and private securities offerings, collaborative arrangements with third parties and other strategic alliances and business transactions. We currently do not have
any commitments to obtain additional funds, and may be unable to obtain sufficient funding in the future on acceptable terms, if at all. If we cannot obtain funding, we will need to delay, scale back or eliminate research and development programs or
enter into collaborations with third parties to commercialize potential products or technologies that we might otherwise seek to develop or commercialize ourselves, or seek other arrangements. If we engage in collaborations, we may receive lower
consideration upon commercialization of such products than if we had not entered into such arrangements, or if we entered into such arrangements at later stages in the product development process. Additional factors that may impact our ability to
raise capital are described under Risk Factors.

In September 2005, we completed the sale of 11,400,000 shares of our common
stock for gross proceeds of $24.5 million We believe that our current cash, cash equivalents and short-term investments at December 31, 2005 are sufficient to meet our research and development goals and sustain operations through 2006.

Contractual Cash Obligations

The table below sets forth our contractual obligations at December 31, 2005 (in thousands):



|                                                        |  |       |       |                             |   |           |  |           |     |               |   |   |  |   |  
|------------------------------------------------------- |  | ----- | ----- | --------------------------- | - | --------- |  | --------- | --- | ------------- | - | - |  | - | -
|                                                        |  |       |       | Cash Payments Due by Period
|Contractual Cash Obligations                            |  | Total |       | Less than 1 year            |   | 1-3 years |  | 4-5 years |     | After 5 years
|Operating lease on building1                            |  | $     | 794   |                             | $ | 408       |  | $         | 386 |               | $ |  |  | $ | 
|Clinical trial contracts                                |  |       | 1,990 |                             |   | 1,990     |  |           |    |               |   |  |  |   | 
|Manufacturing contracts                                 |  |       | 627   |                             |   | 627       |  |           |    |               |   |  |  |   | 
|Operating leases and maintenance contracts on equipment |  |       | 271   |                             |   | 115       |  |           | 156 |               |   |  |  |   | 
|G&A contracts                                           |  |       | 614   |                             |   | 614       |  |           |    |               |   |  |  |   | 
|R&D contracts                                           |  |       | 121   |                             |   | 121       |  |           |    |               |   |  |  |   | 
|                                                        |  |       |       |                             |   |           |  |           |     |               |   |   |  |   |  
|Total contractual cash obligations                      |  | $     | 4,417 |                             | $ | 3,875     |  | $         | 542 |               | $ |  |  | $ | 
|                                                        |  |       |       |                             |   |           |  |           |     |               |   |   |  |   |  

---

|1 | The lease provides for escalations relating to increases in the Consumer Price Index not to exceed 7% but no less than 3.5% beginning in December 2002. We have
assumed a minimum lease payment escalation of 3.5% for the purposes of this table.
|- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|ITEM 7A. | QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
|-------- | ----------------------------------------------------------

We are exposed to risks associated
with interest rate changes. Our exposure to market risk for changes in interest rates relates primarily to our investment portfolio. We invest in only U.S. government, government agency, corporate and bank or institutional money market funds with
investment standards comparable to our investment policy. The policy limits the amount of credit exposure we may have to any one issue, issuer or type of investment other than U.S. government debt.

As of December 31, 2005, our portfolio investments consisted of $16.4 million in cash and cash equivalents and $15.8 million in U.S. Treasury or
U.S. government agency debt instruments having a maturity of less than one year. Due to the nature



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of our investment portfolio, management believes that a sudden change in interest rates would not have a material effect on the value of the portfolio.
Management estimates that if the average annualized yield of our investments had decreased by 100 basis points, our interest income for the year ended December 31, 2005 would have decreased by approximately $0.3 million. This estimate assumes
that the decrease occurred on the first day of 2005 and reduced the annualized yield of each investment instrument by 100 basis points. Correspondingly, if the average annualized yield of our investments had increased by 100 basis points, our
interest income for the year ended December 31, 2005 would have increased by $0.3 million. This estimate assumes that the increase occurred on the first day of 2005 and increased the annualized yield of each investment instrument by 100 basis
points. The impact on our future interest income will depend largely on the gross amount of our investment portfolio.

We do not currently
have any significant foreign currency exchange rate risk.



|ITEM 8. | FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA
|------- | -------------------------------------------

See
the Financial Statements beginning on page F-1.



|ITEM 9. | CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE
|------- | ------------------------------------------------------------------------------------

None.



|ITEM 9A. | CONTROLS AND PROCEDURES
|-------- | -----------------------

Evaluation of
Disclosure Controls and Procedures

For the year ended December 31, 2005, we carried out an evaluation, under the supervision and
with the participation of our management, including our President and Chief Executive Officer and our Executive Vice President and Chief Financial Officer (the principal finance and accounting officer), of the effectiveness of the design and
operation of our disclosure controls and procedures pursuant to Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the Exchange Act). Based upon this evaluation, our President and Chief Executive Officer
and our Executive Vice President and Chief Financial Officer concluded that, as of December 31, 2005, our disclosure controls and procedures have been designed and are being operated in a manner that provides reasonable assurance that the
information required to be disclosed by the Company in reports filed under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission. A control
system, no matter how well designed and operated, cannot provide assurance that the objectives of the control system are being met, and no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any,
within a company have been detected.

Managements Report on Internal Control over Financial Reporting

The management of Genaera Corporation is responsible for establishing and maintaining adequate internal control over financial reporting as defined in
Rules 13a-15(f) and 15d-15(f) promulgated under the Exchange Act. Genaeras internal control system was designed to provide reasonable assurance to the Companys management and board of directors regarding the preparation and fair
presentation of published financial statements.

All internal control systems, no matter how well designed, have inherent limitations.
Therefore, even those systems determined to be effective can only provide reasonable assurance with respect to financial statement preparation and presentation.

Genaeras management assessed the effectiveness of the Companys internal control over financial reporting as of December 31, 2005. In making this assessment, it used the criteria set forth by the
Committee of Sponsoring Organizations of the Treadway Commission (COSO) in Internal Control-Integrated Framework. Based on our assessment, we believe that, as of December 31, 2005, the Companys internal control over financial reporting
was effective based on those criteria.

Genaeras independent registered public accounting firm has issued an audit report on our
assessment of the Companys internal control over financial reporting. Their report appears below.

Changes in Internal Control over
Financial Reporting

There have not been any changes in our internal control over financial reporting during the quarter ended
December 31, 2005 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.



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Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Genaera Corporation:

We have audited managements assessment, included in the accompanying
Managements Report on Internal Control over Financial Reporting, that Genaera Corporation maintained effective internal control over financial reporting as of December 31, 2005, based on criteria established in Internal
ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Genaera Corporations management is responsible for maintaining effective internal control over financial reporting and for
its assessment of the effectiveness of internal control over financial reporting. Our responsibility is to express an opinion on managements assessment and an opinion on the effectiveness of the Companys internal control over financial
reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board
(United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an
understanding of internal control over financial reporting, evaluating managements assessment, testing and evaluating the design and operating effectiveness of internal control, and performing such other procedures as we considered necessary
in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A companys internal control over
financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with. generally accepted accounting
principles. A companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and
dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts
and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or
disposition of the companys assets that could have a material effect on the financial statements.

Because of its inherent
limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in
conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, managements assessment
that Genaera Corporation maintained effective internal control over financial reporting as of December 31, 2005, is fairly stated, in all material respects, based on criteria established in Internal ControlIntegrated Framework issued by
the Committee of Sponsoring Organizations of the Treadway Commission (COSO). Also, in our opinion, Genaera Corporation maintained, in all material respects, effective internal control over financial reporting as of December 31, 2005, based on
criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO).

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the balance sheets of Genaera Corporation as of December 31, 2005 and 2004, and the related
statements of operations, changes in stockholders equity and comprehensive loss, and cash flows for each of the years in the three-year period ended December 31, 2005, and our report dated March 6, 2006 expressed an unqualified
opinion on those financial statements.



|                                        
|----------------------------------------
|                                        
|/s/ KPMG LLP                            
|                                        
|Philadelphia, Pennsylvania March 6, 2006



|ITEM 9B. | OTHER INFORMATION
|-------- | -----------------

None.



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PART III

This Part incorporates certain information from our Proxy Statement for the 2006 Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission not later than 120 days after the end of the
fiscal year covered by this Annual Report on Form 10-K. Notwithstanding such incorporation, the sections of our 2006 Proxy Statement entitled Report of the Compensation Committee and Performance Graph shall not be deemed to
be filed as part of this Annual Report.



|ITEM 10. | DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT
|-------- | --------------------------------------------------

Information required by this item concerning our directors is incorporated herein by reference to the section entitled Nominees for Election and Corporate Governance in our Proxy Statement for the 2006 Annual Meeting
of Stockholders. Information required by this item concerning our executive officers is included in Part I of this Annual Report.

The
Company adopted a corporate code of ethics in December 2003. This code of ethics applies to all of the Companys employees and directors and includes the code of ethics for the Companys principal executive officer, principal financial
officer, principal accounting officer or controller within the meaning of the SEC regulations adopted under the Sarbanes-Oxley Act of 2002. The Companys corporate code of ethics is posted under the Investor Relations section of its website at
www.genaera.com. Please note that none of the information on the Companys website is incorporated by reference in this Annual Report.



|ITEM 11. | EXECUTIVE COMPENSATION
|-------- | ----------------------

Information required by
this item is incorporated herein by reference to the section entitled Compensation of Executive Officers and Directors in our Proxy Statement for the 2006 Annual Meeting of Stockholders.



|ITEM 12. | SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
|-------- | ----------------------------------------------------------------------------------------------

Information required by this item is incorporated herein by reference to the section entitled Security Ownership of Certain Beneficial Owners and
Management in our Proxy Statement for the 2006 Annual Meeting of Stockholders.

Information required by this item concerning our
equity compensation plan information is included in Part II of this Annual Report.



|ITEM 13. | CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
|-------- | ----------------------------------------------

Information required by this item is incorporated herein by reference to the section entitled Certain Relationships and Related Transactions in our Proxy Statement for the 2006 Annual Meeting of Stockholders.



|ITEM 14. | PRINCIPAL ACCOUNTANT FEES AND SERVICES
|-------- | --------------------------------------

Information
required by this item is incorporated herein by reference to the section entitled Principal Accountant Fees and Services in our Proxy Statement for the 2006 Annual Meeting of Stockholders.



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PART IV



|ITEM 15. | EXHIBITS AND FINANCIAL STATEMENT SCHEDULES
|-------- | ------------------------------------------

(a) The following
documents are filed as a part of this Annual Report:

1. Index to Financial Statements



|                                                                     |  |     
|-------------------------------------------------------------------- |  | ----
|                                                                     |  | Page
|                                                                     | 
|Report of Independent Registered Public Accounting Firm              |  | F-2 
|                                                                     | 
|Balance Sheets                                                       |  | F-3 
|                                                                     | 
|Statements of Operations                                             |  | F-4 
|                                                                     | 
|Statements of Changes in Stockholders Equity and Comprehensive Loss |  | F-5 
|                                                                     | 
|Statements of Cash Flows                                             |  | F-6 
|                                                                     | 
|Notes to Financial Statements                                        |  | F-7 

2. Financial Statement Schedules

All schedules have been omitted because they are not applicable or not required or the information is shown in the Financial Statements or Notes thereto.

3. Exhibits

The following is a list of exhibits filed as part of this Annual Report on Form 10-K. Where so indicated, exhibits that were previously filed are incorporated by reference. For exhibits incorporated by reference, the location of the exhibit
in the previous filing is indicated parenthetically.



|            |  |   |  |                                                                                                                                                                                                                                                                                                 
|----------- |  | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  |  
|            |  |  
|3.1         |  |   |  | Third Restated Certificate of Incorporation of Genaera Corporation (Incorporated by reference to Exhibit 3.1 filed with the Companys Quarterly Report on Form 10-Q for June 30,
2003)                                                                                                          
|            |  |  
|3.2         |  |   |  | Certificate of Designations, Preferences and Rights of Series A Preferred Stock of Magainin Pharmaceuticals, Inc. dated May 8, 2000 (Incorporated by reference to Exhibit 10.2 filed with the
Companys Quarterly Report on Form 10-Q for June 30, 2000)                                        
|            |  |  
|3.3         |  |   |  | Certificate of Ownership and Merger Merging M Merger Sub, Inc. with and into Magainin Pharmaceuticals Inc. dated March 9, 2001 (Incorporated by reference to Exhibit 3.5 filed with the
Companys Quarterly Report on Form 10-Q for March 31, 2001)                                             
|            |  |  
|3.4         |  |   |  | Certificate of Designations, Preferences and Rights of Series B Preferred Stock of Genaera Corporation dated April 19, 2001 (Incorporated by reference to Exhibit 3.7 filed with the
Companys Quarterly Report on Form 10-Q for March 31, 2001)                                                
|            |  |  
|3.5         |  |   |  | By-laws of Genaera Corporation, as Amended and Restated on May 16, 2002 (Incorporated by reference to Exhibit 3.2 filed with the Companys Quarterly Report on Form 10-Q for June 30,
2002)                                                                                                     
|            |  |  
|3.6         |  |   |  | Amended and Restated Certificate of Designations, Preferences and Rights for the Series C-1 Preferred Stock dated June 9, 2003 (Incorporated by reference to Exhibit 3.1 filed with the
Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on June 12, 2003)
|            |  |  
|3.7         |  |   |  | Amended and Restated Certificate of Designations, Preferences and Rights for the Series C-2 Preferred Stock dated June 9, 2003 (Incorporated by reference to Exhibit 3.2 filed with the
Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on June 12, 2003)
|            |  |  
|4.1         |  |   |  | Specimen copy of stock certificate for shares of Common Stock of Genaera Corporation (Incorporated by reference to Exhibit 4.1 filed with the Companys Quarterly Report on Form 10-Q for
March 31, 2001)                                                                                       
|            |  |  
|10.1        |  | # |  | 1992 Stock Option Plan of the Registrant, as Amended (Incorporated by reference to Exhibit A filed with the Companys Proxy Statement for the 1996 Annual Meeting of
Stockholders)                                                                                                              
|            |  |  
|10.2        |  | # |  | Amended 1998 Equity Compensation Plan, as Amended and Restated on July 22, 2002 (Incorporated by reference to Exhibit 3.2 filed with the Companys Quarterly Report on Form 10-Q for June
30, 2002)                                                                                             



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|            |  |    |  |                                                                                                                                                                                                                                                                              
|----------- |  | -- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  |   
|            |  |   
|10.3        |  | #  |  | 2004 Stock-Based Incentive Plan (Incorporated by reference to Exhibit 10.0 filed with the Companys Quarterly Report on Form 10-Q for June 30, 2004)                                                                                                                         
|            |  |   
|10.4        |  | #  |  | Form of Stock Option Agreement under Stock Option Plans (Incorporated by reference to Exhibit 4.6 filed with the Companys Registration Statement No. 33-43579 on Form
S-1)                                                                                                  
|            |  |   
|10.5        |  | #  |  | Amended and Restated Consulting Agreement with Michael A. Zasloff, M.D., Ph.D. (Incorporated by reference to Exhibit 10.5 filed with the Companys Annual Report on Form 10-K for December
31, 2001)                                                                         
|            |  |   
|10.6        |  | #+ |  | Employment Agreement with Roy C. Levitt, M.D. (Incorporated by reference to Exhibit 10.24 filed with the Companys Annual Report on Form 10-K for December 31, 1995)                                                                                                         
|            |  |   
|10.6        |  | #  |  | Employment Agreement with John A. Skolas (Incorporated by reference to Exhibit 10.35 filed with the Companys Annual Report on Form 10-K for December 31, 2003)                                                                                                              
|            |  |   
|10.7        |  | #  |  | Employment Agreement with John L. Armstrong, Jr. (Incorporated by reference to Exhibit 10.36 filed with the Companys Annual Report on Form 10-K for December 31, 2003)                                                                                                      
|            |  |   
|10.8        |  | #  |  | Employment Agreement with Roy C. Levitt, M.D. (Incorporated by reference to Exhibit 10.2 filed with the Companys Quarterly Report on Form 10-Q for June 30, 2004)                                                                                                           
|            |  |   
|10.9        |  | #  |  | Form and Schedule of Stock Awards to Executive Officers (Incorporated by reference to Exhibit 4.7 filed with the Companys Registration Statement No. 333-62073 on Form
S-8)                                                                                                 
|            |  |   
|10.10       |  | #  |  | Change in Control Agreement with Roy C. Levitt, M.D. (Incorporated by reference to Exhibit 10.1 filed with the Companys Quarterly Report on Form 10-Q for September 30,
2004)                                                                                               
|            |  |   
|10.11       |  | #  |  | Change in Control Agreement with John L. Armstrong, Jr. (Incorporated by reference to Exhibit 10.2 filed with the Companys Quarterly Report on Form 10-Q for September 30,
2004)                                                                                            
|            |  |   
|10.12       |  | #  |  | Change in Control Agreement with John A. Skolas (Incorporated by reference to Exhibit 10.3 filed with the Companys Quarterly Report on Form 10-Q for September 30, 2004)                                                                                                    
|            |  |   
|10.13       |  | #  |  | Employment Agreement with Michael J. Gast, M.D. (Incorporated by reference to Exhibit 10.42 filed with the Companys Annual Report on Form 10-K for December 31, 2004)                                                                                                       
|            |  |   
|10.14       |  | #  |  | Letter Agreement between the Company and Roy C. Levitt, M.D. dated October 17, 2005 (Incorporated by reference to Exhibit 10.1 filed with the Companys Current Report on Form 8-K filed
with the Securities and Exchange Commission on October 18, 2005)                    
|            |  |   
|10.15       |  | #  |  | Amendment to the Letter Agreement between the Company and John L. Armstrong, Jr. dated December 1, 2005 (Incorporated by reference to Exhibit 10.1 filed with the Companys Current Report
on Form 8-K filed with the Securities and Exchange Commission on December 6, 2005)
|            |  |   
|10.16       |  |    |  | Lease with respect to Plymouth Meeting, Pennsylvania office and laboratory space dated December 13, 2001 (Incorporated by reference to Exhibit 10.12 filed with the Companys Annual
Report on Form 10-K for December 31, 2001)                                              
|            |  |   
|10.17       |  |    |  | Amended Patent License Agreement and Sponsored Research Agreement with The Childrens Hospital of Philadelphia (Incorporated by reference to Exhibit 10.1 filed with the Companys
Quarterly Report on Form 10-Q for June 30, 2003)                                          
|            |  |   
|10.18       |  |    |  | License Agreement with Multiple Peptide Systems, Inc. (Incorporated by reference to Exhibit 10.12 filed with the Companys Registration Statement No. 33-43579 on Form
S-1)                                                                                                  
|            |  |   
|10.19       |  |    |  | Second Amendment to License Agreement with Multiple Peptide Systems, Inc. (Incorporated by reference to Exhibit 10.30 filed with the Companys Quarterly Report on Form 10-Q for September
30, 1996)                                                                         
|            |  |   
|10.20       |  | +  |  | Assignment Agreement between Magainin Pharmaceuticals, Inc., Roy C. Levitt, M.D. and GeneQuest, Inc. (Incorporated by reference to Exhibit 10.25 filed with the Companys Annual Report on
Form 10-K for December 31, 1995)                                                  
|            |  |   
|10.21       |  | +  |  | Development, Supply and Distribution Agreement, effective as of February 12, 1997, with SmithKline Beecham Corporation (Incorporated by reference to Exhibit 10.29 filed with the
Companys Annual Report on Form 10-K for December 31, 1996)                                



30



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##### Table of Contents

|            |  |   |  |                                                                                                                                                                                                                                                                                                                                     
|----------- |  | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  |  
|            |  |  
|10.22       |  |   |  | Settlement and Termination Agreement between Abbott Laboratories Inc. and Magainin Pharmaceuticals, Inc., effective September 8, 1999 (Incorporated by reference to Exhibit 99.1 filed with the
Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on September 28, 1999)                       
|            |  |  
|10.23       |  |   |  | Registration Rights Agreement between Magainin Pharmaceuticals, Inc. and Genentech, Inc. dated April 28, 2000 (Incorporated by reference to Exhibit 10.4 filed with the Companys
Quarterly Report on Form 10-Q for June 30, 2000)                                                                                                  
|            |  |  
|10.24       |  | + |  | Amended License Agreement between Magainin Pharmaceuticals, Inc. and Ludwig Institute for Cancer Research dated December 20, 1999 (Incorporated by reference to Exhibit 10.1 filed with the
Companys Quarterly Report on Form 10-Q for March 31, 2001)                                                                             
|            |  |  
|10.25       |  | + |  | Second Research Agreement between Magainin Pharmaceuticals, Inc. and Ludwig Institute for Cancer Research dated December 20, 1999 (Incorporated by reference to Exhibit 10.2 filed with the
Companys Quarterly Report on Form 10-Q for March 31, 2001)                                                                             
|            |  |  
|10.26       |  | + |  | Notice of Renewal of Second Research Agreement between Genaera Corporation and Ludwig Institute for Cancer Research dated October 31, 2001 (Incorporated by reference to Exhibit 10.22 filed
with the Companys Annual Report on Form 10-K for December 31, 2001)                                                                   
|            |  |  
|10.27       |  |   |  | Settlement Agreement between Genaera Corporation and Genentech, Inc. dated April 18, 2001 (Incorporated by reference to Exhibit 10.3 filed with the Companys Quarterly Report on Form
10-Q for March 31, 2001)                                                                                                                     
|            |  |  
|10.28       |  | + |  | Collaboration and License Agreement between Genaera Corporation and MedImmune, Inc. dated April 19, 2001 (Incorporated by reference to Exhibit 10.4 filed with the Companys Quarterly
Report on Form 10-Q for March 31, 2001)                                                                                                      
|            |  |  
|10.29       |  |   |  | Amendment to Collaboration and License Agreement between Genaera Corporation and MedImmune, Inc. effective April 19, 2001 (Incorporated by reference to Exhibit 10.25 filed with the
Companys Annual Report on Form 10-K for December 31, 2001)                                                                                    
|            |  |  
|10.30       |  |   |  | Preferred Stock Purchase Agreement between Genaera Corporation and MedImmune, Inc. dated April 19, 2001 (Incorporated by reference to Exhibit 10.5 filed with the Companys Quarterly
Report on Form 10-Q for March 31, 2001)                                                                                                       
|            |  |  
|10.31       |  |   |  | Warrants to purchase shares of Genaera Corporation Common Stock by Ladenburg Thalmann dated December 12, 2001 (Incorporated by reference to Exhibit 10.27 filed with the Companys Annual
Report on Form 10-K for December 31, 2001)                                                                                                
|            |  |  
|10.32       |  |   |  | Placement Agency Agreement dated April 5, 2002 by and between Genaera Corporation and Wells Fargo Securities, LLC (Incorporated by reference to Exhibit 10.1 filed with the Companys
Current Report on Form 8-K filed with the Securities and Exchange Commission on April 8, 2002)                                                
|            |  |  
|10.33       |  | + |  | License, Development and Commercialization Agreement Between Genaera Corporation and Laboratorios Bago SA (Incorporated by reference to Exhibit 10.1 filed with the Companys Quarterly
Report on Form 10-Q for September 30, 2002)                                                                                                 
|            |  |  
|10.34       |  |   |  | Placement Agency Agreement between Genaera Corporation and Fortis Securities Inc. dated as of November 11, 2003 (Incorporated by reference to Exhibit 99.2 with the Companys Current
Report on Form 8-K filed with the Securities and Exchange Commission on November 14, 2003)                                                    
|            |  |  
|10.35       |  |   |  | Consent Agreement to Amend and Restate the Certificates of Designations, Preferences and Rights for the Series C-1 Preferred Stock and Series C-2 Preferred Stock (Incorporated by reference to
Exhibit 10.1 filed with the Companys Current Report on Form 8-K filed with the Securities and Exchange Commission on June 12, 2003)
|            |  |  
|10.36       |  |   |  | Series C-1 and C-2 Preferred Stock and Warrant Purchase Agreement dated May 23, 2003 (Incorporated by reference to Exhibit 10.1 filed with the Companys Current Report on Form 8-K filed
with the Securities and Exchange Commission on May 28, 2003)                                                                              
|            |  |  
|10.37       |  |   |  | Amendment No. 1 to Series C-1 and C-2 Preferred Stock and Warrant Purchase Agreement dated June 9, 2003 (Incorporated by reference to Exhibit 10.2 filed with the Companys Current Report
on Form 8-K filed with the Securities and Exchange Commission on June 12, 2003)                                                          



31



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##### Table of Contents

|            |  |   |  |                                                                                                                                                                                                                                                                                                                   
|----------- |  | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No. |  |  
|            |  |  
|10.38       |  |   |  | Form of Warrants to Purchase 1,500,000 Shares of Common Stock (Incorporated by reference to Exhibit 10.2 filed with the Companys Current Report on Form 8-K filed with the Securities and
Exchange Commission on May 28, 2003)                                                                                   
|            |  |  
|10.39       |  |   |  | Form of Warrants to Purchase 500,000 Shares of Common Stock (Incorporated by reference to Exhibit 10.3 filed with the Companys Current Report on Form 8-K filed with the Securities and
Exchange Commission on May 28, 2003)                                                                                     
|            |  |  
|10.40       |  |   |  | Placement Agency Agreement dated September 12, 2005 among Genaera Corporation, RBC Capital Markets Corporation and Fortis Securities LLC (Incorporated by reference to Exhibit 99.2 filed with
the Companys Current Report on Form 8-K/A filed with the Securities and Exchange Commission on September 15, 2005)
|            |  |  
|10.41       |  |   |  | Securities Purchase Agreement dated September 9, 2005 by and between Genaera Corporation and Certain Purchasers (Incorporated by reference to Exhibit 99.1 filed with the Companys
Current Report on Form 8-K/A filed with the Securities and Exchange Commission on September 15, 2005)                         
|            |  |  
|10.42       |  | * |  | Form of Warrants to Purchase 3,420,000 Shares of Common Stock                                                                                                                                                                                                                                                     
|            |  |  
|23.1        |  | * |  | Consent of KPMG LLP, Independent Registered Public Accounting Firm                                                                                                                                                                                                                                                
|            |  |  
|24.1        |  | * |  | Power of Attorney (Included on signature page of this Annual Report on Form 10-K)                                                                                                                                                                                                                                 
|            |  |  
|31.1        |  | * |  | Certification of Chief Executive Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities and Exchange Act of 1934, as amended, as adopted pursuant to section 302 of
the Sarbanes-Oxley Act of 2002                                                                                    
|            |  |  
|31.2        |  | * |  | Certification of Chief Financial Officer pursuant to Rules 13a-14(a) and 15d-14(a) promulgated under the Securities and Exchange Act of 1934, as amended, as adopted pursuant to section 302 of
the Sarbanes-Oxley Act of 2002                                                                                    
|            |  |  
|32.1        |  | * |  | Certification of Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002                                                                                                                                                                 
|            |  |  
|32.2        |  | * |  | Certification of Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002                                                                                                                                                                 



---

Explanation of Footnotes to Listing of Exhibits:



|* | Filed herewith.
|- | ---------------



|# | Compensation plan or arrangement in which directors or executive officers are eligible to participate.
|- | ------------------------------------------------------------------------------------------------------



|+ | Portions of this Exhibit were omitted and filed separately with the Securities and Exchange Commission pursuant to an order granting confidential treatment.
|- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



32



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.



|                    |  |  |  |                     |  |                            |  |                                                
|------------------- |  |  |  | ------------------- |  | -------------------------- |  | -----------------------------------------------
|                    |  |  |  | GENAERA CORPORATION
|                    |  |  | 
|Date: March 6, 2006 |  |  |  | By:                 |  | /s/ John L. Armstrong, Jr.
|                    |  |  |  |                     |  |                            |  | John L. Armstrong, Jr.                         
|                    |  |  |  |                     |  |                            |  | President, Chief Executive Officer and Director

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed
below by the following persons on behalf of the Registrant in the capacities and on the dates indicated.

Each person whose signature
appears below in so signing also makes, constitutes and appoints John L. Armstrong, Jr., President and Chief Executive Officer, his true and lawful attorney-in-fact, in his name, place and stead to execute and cause to be filed with the Securities
and Exchange Commission any or all amendments to this report.



|                                                      |  |                                                                                                   |  |              
|----------------------------------------------------- |  | ------------------------------------------------------------------------------------------------- |  | -------------
|Signature                                             |  | Title                                                                                             |  | Date         
|                                                      |  |                                                                                                  
|/s/ John L. Armstrong, Jr. John L. Armstrong, Jr.     |  | President, Chief Executive Officer and Director (Principal Executive Officer)                     |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ R. Frank Ecock R. Frank Ecock                     |  | Director                                                                                          |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ Zola P. Horovitz, Ph.D. Zola P. Horovitz, Ph.D.   |  | Director                                                                                          |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ Osagie O. Imasogie Osagie O. Imasogie             |  | Director                                                                                          |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ Roy C. Levitt, M.D. Roy C. Levitt, M.D.           |  | Director                                                                                          |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ Robert F. Shapiro Robert F. Shapiro               |  | Director                                                                                          |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ John A. Skolas John A. Skolas                     |  | Executive Vice President and Chief Financial Officer
(Principal Financial and Accounting Officer) |  | March 6, 2006
|                                                      |  |                                                                                                  
|/s/ James B. Wyngaarden, M.D James B. Wyngaarden, M.D |  | Director                                                                                          |  | March 6, 2006



33



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##### Table of Contents

GENAERA CORPORATION

INDEX TO FINANCIAL STATEMENTS



|                                                                     |  |     
|-------------------------------------------------------------------- |  | ----
|                                                                     |  | Page
|Report of Independent Registered Public Accounting Firm              |  | F-2 
|                                                                     | 
|Balance Sheets                                                       |  | F-3 
|                                                                     | 
|Statements of Operations                                             |  | F-4 
|                                                                     | 
|Statements of Changes in Stockholders Equity and Comprehensive Loss |  | F-5 
|                                                                     | 
|Statements of Cash Flows                                             |  | F-6 
|                                                                     | 
|Notes to Financial Statements                                        |  | F-7 



F-1



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##### Table of Contents

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

The Board of Directors and
Stockholders

Genaera Corporation:

We have audited the
accompanying balance sheets of Genaera Corporation as of December 31, 2005 and 2004, and the related statements of operations, changes in stockholders equity and comprehensive loss, and cash flows for each of the years in the three-year
period ended December 31, 2005. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and
perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An
audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of Genaera Corporation as of
December 31, 2005 and 2004, and the results of its operations and its cash flows for each of the years in the three-year period ended December 31, 2005, in conformity with U.S. generally accepted accounting principles.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the effectiveness of Genaera Corporations
internal control over financial reporting as of December 31, 2005, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO), and our report
dated March 6, 2006 expressed an unqualified opinion on managements assessment of, and the effective operation of, internal control over financial reporting.



|                                        
|----------------------------------------
|                                        
|/s/ KPMG LLP                            
|                                        
|Philadelphia, Pennsylvania March 6, 2006



F-2



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##### Table of Contents

GENAERA CORPORATION

BALANCE SHEETS

(In thousands, except per share data)



|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                                                                                                                                                  |  | December 31, |         
|                                                                                                                                                                  |  | 2005         |          |   | 2004 |  
|ASSETS                                                                                                                                                            |  |              |          |   |      |   |          |  
|Current assets:                                                                                                                                                   |  |              |          |   |      |   |          |  
|Cash and cash equivalents                                                                                                                                         |  | $            | 16,418   |   |      | $ | 14,217   |  
|Short-term investments (NOTE 3)                                                                                                                                   |  |              | 15,797   |   |      |   | 17,934   |  
|Prepaid expenses and other current assets                                                                                                                         |  |              | 892      |   |      |   | 602      |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total current assets                                                                                                                                              |  |              | 33,107   |   |      |   | 32,753   |  
|Fixed assets, net (NOTE 4)                                                                                                                                        |  |              | 848      |   |      |   | 736      |  
|Other assets                                                                                                                                                      |  |              | 56       |   |      |   | 59       |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total assets                                                                                                                                                      |  | $            | 34,011   |   |      | $ | 33,548   |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|LIABILITIES AND STOCKHOLDERS EQUITY                                                                                                                              |  |              |          |   |      |   |          |  
|Current liabilities:                                                                                                                                              |  |              |          |   |      |   |          |  
|Accounts payable and accrued expenses (NOTE 5)                                                                                                                    |  | $            | 5,946    |   |      | $ | 3,323    |  
|Accrued development expense  short-term (NOTE 15)                                                                                                                |  |              |         |   |      |   | 563      |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total current liabilities                                                                                                                                         |  |              | 5,946    |   |      |   | 3,886    |  
|Other liabilities (NOTE 12)                                                                                                                                       |  |              | 1,781    |   |      |   | 580      |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total liabilities                                                                                                                                                 |  |              | 7,727    |   |      |   | 4,466    |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Commitments and contingencies (NOTE 15)                                                                                                                           |  |              |          |   |      |   |          |  
|Stockholders equity:                                                                                                                                             |  |              |          |   |      |   |          |  
|Preferred stock - $.001 par value; 9,211 shares authorized; none issued and outstanding at December 31, 2005 and 2004                                             |  |              |         |   |      |   |         |  
|Common stock - $.002 par value; 100,000 and 75,000 shares authorized; 68,704 and 57,072 shares issued and outstanding at December 31,
2005 and 2004, respectively |  |              | 137      |   |      |   | 114      |  
|Additional paid-in capital                                                                                                                                        |  |              | 265,756  |   |      |   | 242,145  |  
|Accumulated other comprehensive loss                                                                                                                              |  |              | (77      | ) |      |   | (6       | )
|Accumulated deficit                                                                                                                                               |  |              | (239,532 | ) |      |   | (213,171 | )
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total stockholders equity                                                                                                                                        |  |              | 26,284   |   |      |   | 29,082   |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  
|Total liabilities and stockholders equity                                                                                                                        |  | $            | 34,011   |   |      | $ | 33,548   |  
|                                                                                                                                                                  |  |              |          |   |      |   |          |  

See accompanying notes to financial statements.



F-3



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##### Table of Contents

GENAERA CORPORATION

STATEMENTS OF OPERATIONS

(In thousands, except per share data)



|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|------------------------------------------------------------------------------------------------------ |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                                       |  | Year Ended December 31, |        
|                                                                                                       |  | 2005                    |         |   | 2004 |   |         | 2003 | 
|Collaborative research agreement and grant revenues                                                    |  | $                       | 446     |   |      | $ | 873     |      |  | $ | 1,113   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Costs and expenses:                                                                                    |  |                         |         |   |      |   |         |      |  |   |         |  
|Research and development                                                                               |  |                         | 21,792  |   |      |   | 14,004  |      |  |   | 7,922   |  
|General and administrative                                                                             |  |                         | 5,891   |   |      |   | 4,951   |      |  |   | 2,864   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|                                                                                                       |  |                         | 27,683  |   |      |   | 18,955  |      |  |   | 10,786  |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Loss from operations                                                                                   |  |                         | (27,237 | ) |      |   | (18,082 | )    |  |   | (9,673  | )
|Interest income, net                                                                                   |  |                         | 870     |   |      |   | 327     |      |  |   | 23      |  
|Gain (loss) on sale of fixed assets                                                                    |  |                         | 6       |   |      |   | (118    | )    |  |   | 257     |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net loss                                                                                               |  |                         | (26,361 | ) |      |   | (17,873 | )    |  |   | (9,393  | )
|Dividends on preferred stock, including $3,050 attributable to a beneficial conversion feature in 2003 |  |                         |        |   |      |   |        |      |  |   | (3,085  | )
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net loss applicable to common stockholders                                                             |  | $                       | (26,361 | ) |      | $ | (17,873 | )    |  | $ | (12,478 | )
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net loss applicable to common stockholders per sharebasic and diluted                                 |  | $                       | (0.44   | ) |      | $ | (0.34   | )    |  | $ | (0.32   | )
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Weighted average shares outstandingbasic and diluted                                                  |  |                         | 60,580  |   |      |   | 52,839  |      |  |   | 38,634  |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  

See accompanying notes to financial statements.



F-4



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##### Table of Contents

GENAERA CORPORATION

STATEMENTS OF CHANGES IN STOCKHOLDERS

EQUITY AND COMPREHENSIVE LOSS

(In
thousands)



|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|------------------------------------------------------------------------------------------------------------- |  | --------------- |  | ------------------------ | --- |  | ------------------------------------------ | ------- | - | ------------------ | - | --- | ------------------------- |  | - | -------- | - |  | - | ------- | -
|                                                                                                              |  | Common Stock    |  | AdditionalPaid-inCapital |     |  | AccumulatedOtherComprehensiveIncome (Loss) |         |   | AccumulatedDeficit |   |     | TotalStock-holdersEquity | 
|                                                                                                              |  | Numberof Shares |  | Amount                   |     |  |                                            |        
|Balance at January 1, 2003                                                                                    |  | 35,666          |  | $                        | 71  |  | $                                          | 187,258 |   |                    | $ | 1   |                           |  | $ | (182,819 | ) |  | $ | 4,511   |  
|Exercise of stock options and compensation expense under option grants and stock awards                       |  | 275             |  |                          | 1   |  |                                            | 752     |   |                    |   |    |                           |  |   |         |   |  |   | 753     |  
|Common stock issued pursuant to private placement                                                             |  | 2,050           |  |                          | 4   |  |                                            | 7,889   |   |                    |   |    |                           |  |   |         |   |  |   | 7,893   |  
|Series C-1 and C-2 convertible preferred stock and common stock warrants issued pursuant to private placement |  |                |  |                          |    |  |                                            | 4,922   |   |                    |   |    |                           |  |   |         |   |  |   | 4,922   |  
|Beneficial conversion feature related to the issuance of Series C-1 and C-2 convertible preferred stock       |  |                |  |                          |    |  |                                            | 3,050   |   |                    |   |    |                           |  |   |         |   |  |   | 3,050   |  
|Discount on Series C-1 and C-2 convertible preferred stock                                                    |  |                |  |                          |    |  |                                            | (3,050  | ) |                    |   |    |                           |  |   |         |   |  |   | (3,050  | )
|Conversion of Series B preferred stock                                                                        |  | 2,000           |  |                          | 4   |  |                                            | (4      | ) |                    |   |    |                           |  |   |         |   |  |   |        |  
|Conversion of Series C-1 convertible preferred stock                                                          |  | 2,500           |  |                          | 5   |  |                                            | (5      | ) |                    |   |    |                           |  |   |         |   |  |   |        |  
|Conversion of Series C-2 convertible preferred stock                                                          |  | 2,500           |  |                          | 5   |  |                                            | (5      | ) |                    |   |    |                           |  |   |         |   |  |   |        |  
|Exercise of common stock warrants issued pursuant to May 2003 private placement                               |  | 1,492           |  |                          | 3   |  |                                            | 819     |   |                    |   |    |                           |  |   |         |   |  |   | 822     |  
|Conversion of Series A redeemable convertible preferred stock                                                 |  | 541             |  |                          | 1   |  |                                            | 1,150   |   |                    |   |    |                           |  |   |         |   |  |   | 1,151   |  
|Dividends on Series A redeemable convertible preferred stock                                                  |  |                |  |                          |    |  |                                            |        |   |                    |   |    |                           |  |   | (35      | ) |  |   | (35     | )
|Amortization of beneficial conversion feature                                                                 |  |                |  |                          |    |  |                                            | 3,050   |   |                    |   |    |                           |  |   | (3,050   | ) |  |   |        |  
|Comprehensive loss:                                                                                           |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Net loss                                                                                                      |  |                |  |                          |    |  |                                            |        |   |                    |   |    |                           |  |   | (9,393   | ) |  |   | (9,393  | )
|Carrying value adjustment                                                                                     |  |                |  |                          |    |  |                                            |        |   |                    |   | (1  | )                         |  |   |         |   |  |   | (1      | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Total comprehensive loss                                                                                      |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   | (9,394  | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Balance at December 31, 2003                                                                                  |  | 47,024          |  |                          | 94  |  |                                            | 205,826 |   |                    |   |    |                           |  |   | (195,298 | ) |  |   | 10,622  |  
|Exercise of stock options and compensation expense under option grants and stock awards                       |  | 714             |  |                          | 1   |  |                                            | 2,634   |   |                    |   |    |                           |  |   |         |   |  |   | 2,635   |  
|Common stock issued pursuant to private placements                                                            |  | 9,134           |  |                          | 18  |  |                                            | 33,412  |   |                    |   |    |                           |  |   |         |   |  |   | 33,430  |  
|Exercise of common stock warrants issued pursuant to May 2003 private placement                               |  | 200             |  |                          | 1   |  |                                            | 273     |   |                    |   |    |                           |  |   |         |   |  |   | 274     |  
|Comprehensive loss:                                                                                           |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Net loss                                                                                                      |  |                |  |                          |    |  |                                            |        |   |                    |   |    |                           |  |   | (17,873  | ) |  |   | (17,873 | )
|Carrying value adjustment                                                                                     |  |                |  |                          |    |  |                                            |        |   |                    |   | (6  | )                         |  |   |         |   |  |   | (6      | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Total comprehensive loss                                                                                      |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   | (17,879 | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Balance at December 31, 2004                                                                                  |  | 57,072          |  |                          | 114 |  |                                            | 242,145 |   |                    |   | (6  | )                         |  |   | (213,171 | ) |  |   | 29,082  |  
|Exercise of stock options and compensation expense under option grants and stock awards                       |  | 232             |  |                          |    |  |                                            | 692     |   |                    |   |    |                           |  |   |         |   |  |   | 692     |  
|Common stock issued pursuant to private placement                                                             |  | 11,400          |  |                          | 23  |  |                                            | 22,919  |   |                    |   |    |                           |  |   |         |   |  |   | 22,942  |  
|Comprehensive loss:                                                                                           |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Net loss                                                                                                      |  |                |  |                          |    |  |                                            |        |   |                    |   |    |                           |  |   | (26,361  | ) |  |   | (26,361 | )
|Carrying value adjustment                                                                                     |  |                |  |                          |    |  |                                            |        |   |                    |   | (71 | )                         |  |   |         |   |  |   | (71     | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Total comprehensive loss                                                                                      |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   | (26,432 | )
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  
|Balance at December 31, 2005                                                                                  |  | 68,704          |  | $                        | 137 |  | $                                          | 265,756 |   |                    | $ | (77 | )                         |  | $ | (239,532 | ) |  | $ | 26,284  |  
|                                                                                                              |  |                 |  |                          |     |  |                                            |         |   |                    |   |     |                           |  |   |          |   |  |   |         |  

See accompanying notes to financial statements.



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##### Table of Contents

GENAERA CORPORATION

STATEMENTS OF CASH FLOWS

(In thousands)



|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|------------------------------------------------------------------------------------------------------ |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                                       |  | Year Ended December 31, |        
|                                                                                                       |  | 2005                    |         |   | 2004 |   |         | 2003 | 
|Cash Flows From Operating Activities:                                                                  |  |                         |         |   |      |   |         |      |  |   |         |  
|Net loss                                                                                               |  | $                       | (26,361 | ) |      | $ | (17,873 | )    |  | $ | (9,393  | )
|Adjustments to reconcile net loss to net cash used in operating activities:                            |  |                         |         |   |      |   |         |      |  |   |         |  
|Depreciation and amortization                                                                          |  |                         | 332     |   |      |   | 344     |      |  |   | 489     |  
|Amortization of investment discounts/premiums                                                          |  |                         | 41      |   |      |   | (149    | )    |  |   | (67     | )
|Compensation expense on option grants and equity awards                                                |  |                         | 652     |   |      |   | 841     |      |  |   | 211     |  
|(Gain) loss on sale of fixed assets                                                                    |  |                         | (6      | ) |      |   | 118     |      |  |   | (257    | )
|Changes in operating assets and liabilities:                                                           |  |                         |         |   |      |   |         |      |  |   |         |  
|Prepaid expenses and other assets                                                                      |  |                         | (287    | ) |      |   | (338    | )    |  |   | (75     | )
|Accounts payable and accrued expenses                                                                  |  |                         | 2,623   |   |      |   | 1,406   |      |  |   | 616     |  
|Accrued development expenses                                                                           |  |                         | (563    | ) |      |   | (966    | )    |  |   |        |  
|Other liabilities                                                                                      |  |                         | 1,201   |   |      |   | 95      |      |  |   | 253     |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash used in operating activities                                                                  |  |                         | (22,368 | ) |      |   | (16,522 | )    |  |   | (8,223  | )
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash Flows From Investing Activities:                                                                  |  |                         |         |   |      |   |         |      |  |   |         |  
|Purchase of investments                                                                                |  |                         | (32,975 | ) |      |   | (37,781 | )    |  |   | (19,762 | )
|Proceeds from maturities of investments                                                                |  |                         | 35,000  |   |      |   | 26,500  |      |  |   | 21,350  |  
|Proceeds from sales of fixed assets                                                                    |  |                         | 13      |   |      |   |        |      |  |   | 257     |  
|Capital expenditures                                                                                   |  |                         | (451    | ) |      |   | (103    | )    |  |   | (43     | )
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash provided by (used in) investing activities                                                    |  |                         | 1,587   |   |      |   | (11,384 | )    |  |   | 1,802   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash Flows From Financing Activities:                                                                  |  |                         |         |   |      |   |         |      |  |   |         |  
|Payments on notes payable                                                                              |  |                         |        |   |      |   |        |      |  |   | (2,500  | )
|Net proceeds from issuance of Series C-1 and C-2 convertible preferred stock and common stock warrants |  |                         |        |   |      |   |        |      |  |   | 4,922   |  
|Net proceeds from issuance of common stock                                                             |  |                         | 22,942  |   |      |   | 33,430  |      |  |   | 7,893   |  
|Proceeds from exercise of options and warrants                                                         |  |                         | 40      |   |      |   | 2,068   |      |  |   | 1,363   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net cash provided by financing activities                                                              |  |                         | 22,982  |   |      |   | 35,498  |      |  |   | 11,678  |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Net increase in cash and cash equivalents                                                              |  |                         | 2,201   |   |      |   | 7,592   |      |  |   | 5,257   |  
|Cash and cash equivalents at beginning of year                                                         |  |                         | 14,217  |   |      |   | 6,625   |      |  |   | 1,368   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash and cash equivalents at end of year                                                               |  | $                       | 16,418  |   |      | $ | 14,217  |      |  | $ | 6,625   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Supplemental Cash Flow Information:                                                                    |  |                         |         |   |      |   |         |      |  |   |         |  
|Cash paid for interest                                                                                 |  | $                       |        |   |      | $ | 2       |      |  | $ | 76      |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  
|Conversion of Series A redeemable convertible preferred stock into common stock                        |  | $                       |        |   |      | $ |        |      |  | $ | 1,117   |  
|                                                                                                       |  |                         |         |   |      |   |         |      |  |   |         |  

See accompanying notes to financial statements.



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



|NOTE 1. | The Company
|------- | -----------

Genaera Corporation
(Genaera or the Company), a Delaware corporation, was incorporated on June 29, 1987. Genaera Corporation is a biopharmaceutical company committed to developing medicines to address substantial unmet medical needs in
major pharmaceutical markets. The Companys research and development efforts are focused on anti-angiogenesis and respiratory diseases.

In September 2000, the Company formed a subsidiary, M Merger Sub, Inc. The subsidiary transacted no business and had no assets, but was required to file state and federal tax returns. In March 2001, the Companys subsidiary was merged
into Genaera Corporation. In 2002 and 2003, the Company was required to file income tax returns on behalf of the subsidiary in Pennsylvania. The subsidiarys obligation to file income tax returns was terminated at the end of 2003 by filing
withdrawal documents with the Pennsylvania Department of Revenue and the Companys financial statements no longer refer to a consolidated subsidiary.

The Company is managed and operated as one business. A single management team that reports to the Chief Executive Officer comprehensively manages the entire business. Accordingly, the Company does not prepare discrete
financial information with respect to separate product areas or by location, and does not have separately reportable segments as defined by Statement of Financial Accounting Standards (SFAS) No. 131, Disclosures about Segments of
an Enterprise and Related Information.

Liquidity

The Company has not generated any revenues from product sales and has funded operations primarily from the proceeds of public and private placements of its securities. Substantial additional financing will be required
by the Company to fund its research and development activities. No assurance can be given that any such financing will be available when needed or that the Companys research and development efforts will be successful.

The Company regularly explores alternative means of financing its operations and seeks funding through various sources, including public and private
securities offerings and collaborative arrangements with third parties. The Company currently does not have any commitments to obtain additional funds and may be unable to obtain sufficient funding in the future on acceptable terms, if at all. If
the Company cannot obtain funding, it will need to delay, scale back or eliminate research and development programs or enter into collaborations with third parties to commercialize potential products or technologies that it might otherwise seek to
develop or commercialize independently, or seek other arrangements. If the Company engages in collaborations, it will receive lower consideration upon commercialization of such products than if it had not entered into such arrangements or if it
entered into such arrangements at later stages in the product development process.

In September 2005, the Company completed the sale of
11,400,000 shares of its common stock for net proceeds of $22,942,000. The Company believes its current cash, cash equivalents and short-term investments at December 31, 2005 are sufficient to meet its research and development goals and sustain
operations through 2006.



|NOTE 2. | Summary of Significant Accounting Policies
|------- | ------------------------------------------

Use
of Estimates - The preparation of financial statements in conformity with U.S. generally accepted accounting principles requires management to make estimates and assumptions that affect the amounts reported in the financial statements and
related notes. Actual results could differ from those estimates.

Cash and Cash Equivalents - The Company considers all highly
liquid investment instruments purchased with a maturity of three months or less to be cash equivalents.

Investments - Investments
purchased with a maturity of more than three months that mature less than twelve months from the balance sheet date are classified as short-term investments. Long-term investments are those with maturities greater than twelve months from the balance
sheet date. The Company generally holds investments to maturity; however, since the Company may, from time to time, sell securities to meet cash requirements, the Company classifies its investments as available-for-sale as defined by SFAS
No. 115, Accounting for Certain



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



Investments in Debt and Equity Securities. Available-for-sale securities are carried at market value with unrealized gains and losses reported as a
separate component of stockholders equity. Declines in the value of individual securities are assessed to determine whether the decline is other than temporary. Other than temporary declines in the value of available-for-sale securities are
recorded in the statement of operations. Gross realized gains and losses on the sales of investment securities are determined using the specific identification method.

Fixed Assets and Depreciation - Fixed assets are recorded at cost and depreciated using the straight-line method over the estimated useful lives of the assets including: three (3) years for computers and
software, five (5) years for laboratory and office equipment, and seven (7) years for furniture and fixtures. Leasehold improvements are amortized using the straight-line method over the term of the respective lease, or their estimated
useful lives, whichever is shorter. Expenditures for maintenance and repairs are charged to expense as incurred.

Impairment of
Long-Lived Assets - In accordance with SFAS No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets (SFAS 144), long-lived assets subject to amortization, such as fixed assets, are reviewed for impairment
whenever events or changes in circumstances indicate that the carrying amount of the asset may not be recoverable. Recoverability of assets to be held and used is measured by a comparison of the carrying amount of the asset to the estimated
undiscounted future cash flows expected to be generated by the asset. If the carrying amount of the asset exceeds its estimated future cash flows, an impairment charge is recognized in the amount by which the carrying amount of the asset exceeds the
fair value of the asset. Assets to be disposed of are separately presented in the balance sheet and reported at the lower of the carrying amount or fair value less costs to sell, and are no longer depreciated. The assets and liabilities of a
disposal group classified as held-for-sale are presented separately in the appropriate asset and liability sections of the balance sheet. The Company has not recognized any impairment losses as of December 31, 2005.

Revenue Recognition - In accordance with Staff Accounting Bulletin (SAB) No. 104, Revenue Recognition(SAB
104) revenues from research and development arrangements are recognized in accordance with the terms of the related agreements, either as services are performed or as milestones are achieved. Revenues related to up-front fees are deferred and
recognized over specified future performance periods.

SAB 104 requires companies to identify separate units of accounting based on the
consensus reached in Emerging Issues Task Force (EITF) Issue No. 00-21,Revenue Arrangements with Multiple Deliverables (EITF 00-21). EITF 00-21 provides guidance on how to determine when an arrangement involving
multiple revenue-generating activities or deliverables should be divided into separate units of accounting for revenue recognition purposes and, if this division is required, how the arrangement consideration should be allocated among the separate
units of accounting. The adoption of EITF 00-21 did not impact the Companys historical financial position or results of operations, but could affect the timing pattern of revenue recognition for future collaborative research and/or licensing
agreements.

In January 2002, the EITF issued EITF Issue No. 01-14, Income Statement Characterization of Reimbursements Received
for Out-of-Pocket Expenses Incurred (EITF 01-14). In accordance with EITF 01-14, reimbursements received for out-of-pocket expenses are characterized as revenue in the accompanying statements of operations for all periods
presented.

Research and Development - Research and development (R&D) expenses include related salaries, facility
costs, contract costs, contract manufacturing costs and costs associated with collaborative R&D arrangements. In addition, the Company funds R&D at other research institutions under agreements that are generally cancelable. R&D expenses
also include external activities such as investigator-sponsored trials. All such costs are charged to R&D expense systematically as incurred, which may be measured by patient enrollment or the passage of time.

Patent Costs - Patent-related costs, including professional fees and filing fees, are expensed as incurred.

Lease Expense - Expense related to the facility lease is recorded on a straight-line basis over the lease term. The difference between rent
expense incurred and the amount paid is recorded as deferred rent and is classified under Other Liabilities on the balance sheet.

Stock-Based Compensation - The Companys stock-based compensation awards include stock options granted to employees, restricted stock granted to employees and stock options and restricted stock granted to non-employee



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



service providers. The Company accounts for its stock options under the intrinsic-value-based method set forth by Accounting Principles Board
(APB) Opinion No. 25, Accounting for Stock Issued to Employees (APB 25), and related interpretations, including Financial Accounting Standards Board (FASB) Interpretation No. 44, Accounting for
Certain Transactions involving Stock Compensation. Under this method, compensation cost is recorded on the date of grant only if the current market price of the underlying stock exceeds the exercise price. SFAS No. 123, Accounting for
Stock-Based Compensation(SFAS 123), established accounting and disclosure requirements using a fair-value-based method of accounting for stock-based employee compensation. As allowed by SFAS 123, the Company has elected to continue
to apply the intrinsic-value-based method of accounting described above. With regard to stock option grants to employees, the Company has adopted the disclosure only requirements of SFAS 123. The following table illustrates the effect on net loss if
the fair-value-based method had been applied to all outstanding and unvested stock-based awards for the years ended December 31, 2005, 2004 and 2003 (in thousands, except per share data).



|                                                                                                                            |  |      |         |   |      |   |         |      |  |   |         |  
|--------------------------------------------------------------------------------------------------------------------------- |  | ---- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | -
|                                                                                                                            |  | 2005 |         |   | 2004 |   |         | 2003 | 
|Net loss applicable to common stockholders, as reported                                                                     |  | $    | (26,361 | ) |      | $ | (17,873 | )    |  | $ | (12,478 | )
|Add: Stock-based employee compensation expense included in reported net loss applicable to common stockholders              |  |      | 548     |   |      |   | 729     |      |  |   | 176     |  
|Deduct: Total stock-based employee compensation expense determined under fair-value-based method for all stock-based awards |  |      | (2,757  | ) |      |   | (1,561  | )    |  |   | (1,692  | )
|                                                                                                                            |  |      |         |   |      |   |         |      |  |   |         |  
|Pro forma net loss applicable to common stockholders                                                                        |  | $    | (28,570 | ) |      | $ | (18,705 | )    |  | $ | (13,994 | )
|                                                                                                                            |  |      |         |   |      |   |         |      |  |   |         |  
|Net loss applicable to common stockholders per share  basic and diluted:                                                   |  |      |         |   |      |   |         |      |  |   |         |  
|As reported                                                                                                                 |  | $    | (0.44   | ) |      | $ | (0.34   | )    |  | $ | (0.32   | )
|                                                                                                                            |  |      |         |   |      |   |         |      |  |   |         |  
|Pro forma                                                                                                                   |  | $    | (0.47   | ) |      | $ | (0.35   | )    |  | $ | (0.36   | )
|                                                                                                                            |  |      |         |   |      |   |         |      |  |   |         |  

The resulting effect on pro forma net loss applicable to common stockholders and pro forma net
loss applicable to common stockholders per share disclosed above may not be representative of the effects on a pro forma basis in future years. The fair value of each option grant is estimated on the date of grant using the Black-Scholes
option-pricing model with the following assumptions:



|                                                               |  |      |             |      |   |             |  |   |           
|-------------------------------------------------------------- |  | ---- | ----------- | ---- | - | ----------- |  | - | ----------
|                                                               |  | 2005 |             | 2004 |   | 2003       
|Range of risk free interest rates                              |  |      | 3.7% - 4.5% |      |   | 3.0% - 4.0% |  |   | 3.6% -3.9%
|Dividend yield                                                 |  |      | 0%          |      |   | 0%          |  |   | 0%        
|Volatility factor                                              |  |      | 125%        |      |   | 121%        |  |   | 121%      
|Weighted average expected life of options (in years)           |  |      | 5.0         |      |   | 6.0         |  |   | 6.0       
|Weighted average fair value of options granted during the year |  | $    | 1.52        |      | $ | 3.21        |  | $ | 2.84      

On December 16, 2004, the FASB published SFAS No. 123 (Revised 2004), Share-Based
Payment (SFAS 123R). SFAS 123R requires that compensation cost related to share-based payment transactions be recognized in the financial statements. Share-based payment transactions within the scope of SFAS 123R include stock
options, restricted stock plans, performance-based awards, stock appreciation rights and employee share purchase plans. The provisions of SFAS 123R are effective as of the first annual period that begins after June 15, 2005. Accordingly, the
Company will implement SFAS 123R in the first quarter of fiscal year 2006. The implications of this revised standard will materially impact the Companys results of operations in the first quarter of fiscal year 2006 and thereafter. If the
Company had applied the provisions of SFAS 123R to the financial statements for the years ended December 31, 2005, 2004 and 2003, the net loss would have increased by approximately $2,209,000, $832,000 and $1,516,000, respectively.

Income Taxes - The Company accounts for income taxes using the asset and liability method as prescribed by SFAS No. 109, Accounting for
Income Taxes. Deferred tax assets and liabilities are determined based on differences between the financial reporting and tax bases of assets and liabilities, and net operating losses and credit carryforwards. Deferred tax assets and liabilities
are measured using the enacted tax rates and laws that will be in



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



effect when the temporary differences are expected to reverse. The measurement of deferred tax assets is reduced, if necessary, by a valuation allowance for
any tax benefits that are not expected to be realized. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in the period in which tax rate changes are enacted.

Loss Per Share - The Company calculates loss per share under the provisions of SFAS No. 128, Earnings Per Share(SFAS
128). SFAS 128 requires a dual presentation of basic and diluted loss per share on the face of the statement of operations. Basic loss per share is computed by dividing the net loss applicable to common stockholders by
the weighted average number of shares of common stock outstanding during each period. Diluted loss per share includes the dilutive effect, if any, from the potential exercise or conversion of securities, such as stock options and warrants, which
would result in the issuance of shares of common stock. For the years ended December 31, 2005, 2004, and 2003, options and warrants to purchase 10,204,516, 5,376,641 and 4,555,291 shares of the Companys common stock, respectively, were
not included in the calculation of the diluted per share amounts as their effect was anti-dilutive. Basic and diluted loss per share amounts are the same as the Company reported a loss for all periods presented.

Comprehensive Income - SFAS No. 130, Reporting Comprehensive Income, establishes standards for the reporting of comprehensive income
and its components. Comprehensive income consists of reported net income or loss and other comprehensive income (i.e., other gains and losses affecting stockholders equity that, under U.S. generally accepted accounting principles, are excluded
from net income or loss as reported on the statement of operations). With regard to the Company, other comprehensive income consists of unrealized gains and losses on available-for-sale securities.



|NOTE 3. | Investments
|------- | -----------

The Company invests in securities of
the U.S. Treasury and U.S. government agencies. Excess cash is invested on a short-term basis in U.S. government-based money market funds. At December 31, 2005 and 2004, the Company had $5,950,000 and $13,939,000, respectively, invested in U.S.
Treasury securities and $9,847,000 and $3,995,000, respectively, invested in U.S. government agency securities. The Company had unrealized losses of $77,000 and $6,000 at December 31, 2005 and 2004, respectively. The Company realized $1,000 of
gains on its investments during the year ended December 31, 2003.



|NOTE 4. | Fixed Assets
|------- | ------------

Fixed assets are summarized as
follows (in thousands):



|                                               |  |                  |        |   |                  |   |        |  
|---------------------------------------------- |  | ---------------- | ------ | - | ---------------- | - | ------ | -
|                                               |  | December 31,2005 |        |   | December 31,2004 |  
|Laboratory and office equipment                |  | $                | 704    |   |                  | $ | 379    |  
|Computers and software                         |  |                  | 318    |   |                  |   | 237    |  
|Furniture and fixtures                         |  |                  | 147    |   |                  |   | 128    |  
|Leasehold improvements                         |  |                  | 1,150  |   |                  |   | 1,137  |  
|                                               |  |                  |        |   |                  |   |        |  
|                                               |  |                  | 2,319  |   |                  |   | 1,881  |  
|Less accumulated depreciation and amortization |  |                  | (1,471 | ) |                  |   | (1,145 | )
|                                               |  |                  |        |   |                  |   |        |  
|                                               |  | $                | 848    |   |                  | $ | 736    |  
|                                               |  |                  |        |   |                  |   |        |  

Depreciation expense for the years ended December 31, 2005, 2004 and 2003 was $332,000,
$344,000 and $489,000, respectively. During the year ended December 31, 2004, the Company removed approximately $4,100,000 of fully depreciated fixed assets from its records.



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GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



|NOTE 5. | Accounts Payable and Accrued Expenses
|------- | -------------------------------------

Accounts
payable and accrued expenses consist of the following (in thousands):



|                                |  |                  |       |                  |   |      
|------------------------------- |  | ---------------- | ----- | ---------------- | - | -----
|                                |  | December 31,2005 |       | December 31,2004
|Accounts payable                |  | $                | 1,495 |                  | $ | 1,233
|Employee compensation           |  |                  | 1,408 |                  |   | 693  
|Manufacturing development costs |  |                  | 626   |                  |   | 357  
|Professional fees               |  |                  | 191   |                  |   | 298  
|Preclinical costs               |  |                  | 121   |                  |   | 284  
|Clinical and regulatory costs   |  |                  | 1,977 |                  |   | 221  
|Other                           |  |                  | 128   |                  |   | 237  
|                                |  |                  |       |                  |   |      
|                                |  | $                | 5,946 |                  | $ | 3,323
|                                |  |                  |       |                  |   |      



|NOTE 6. | Note Payable
|------- | ------------

In the second quarter of 2002, the
Company refinanced its $2,500,000 note payable with Merrill Lynch Bank USA. Under the terms of this note payable, the Company made monthly interest-only payments at an annual rate of 5.346%, with principal due in June 2003. In June 2003, the
Companys note payable matured and was not refinanced. Interest expense related to this note payable for the year ended December 31, 2003 was $61,000.



|NOTE 7. | Preferred Stock
|------- | ---------------

The Companys certificate of
incorporation provides the board of directors the power to issue shares of preferred stock without stockholder approval. This preferred stock could have voting rights, including voting rights that could be superior to that of the Companys
common stock, and the board of directors has the power to determine these voting rights. At December 31, 2005 and 2004, all of the 9,211,031 shares of preferred stock authorized under the Companys Certificate of Incorporation are
undesignated and unissued.

In 2003, the Company sold 2,500 shares of Series C-1 convertible preferred stock (the Series C-1
Preferred Stock) and 2,500 shares of Series C-2 convertible preferred stock (the Series C-2 Preferred Stock) (the Series C-1 Preferred Stock and the Series C-2 Preferred Stock are collectively referred to as the Series C
Preferred Stock) and warrants. The Series C Preferred Stock had a conversion price that was below the quoted market price of the Companys common stock at the time of sale. The Company calculated a beneficial conversion feature of
$3,050,000, which represents the excess of the fair value of the Series C Preferred Stock issued over the proceeds allocable to the Series C Preferred Stock. The value of the Series C Preferred Stock issued was estimated based on the conversion
feature and the value of the warrants issued was estimated using a Black-Scholes model and the amount of the proceeds allocable to the Series C Preferred Stock and warrants was based on the relative fair values of the securities. The Company was
amortizing the value of the beneficial conversion feature as a preferred stock dividend over the 18-month period from the date of issuance of the Series C Preferred Stock to the date on which the Series C Preferred Stock was first known to be
convertible. All of the Series C Preferred Stock became convertible before the end of the 18-month period as the Companys common stock price met defined thresholds. Therefore, the entire amount of the beneficial conversion feature was
recognized as a dividend in 2003.



|NOTE 8. | Common Stock
|------- | ------------

In November 2003, the Company sold
2,050,000 shares of its common stock, through a private placement, at a price of $4.15 per share. Net proceeds to the Company from the offering totaled $7,893,000, after offering costs, which included a cash fee paid to the placement agent.

On January 21, 2004, the Company sold 4,950,500 shares of its common stock to four institutional investors in a private placement at
a purchase price of $4.04 per share. Net proceeds to the Company from the offering totaled approximately $19,930,000 after offering costs of approximately $70,000. The share price was calculated based on a 10% discount to the five-day moving average
of the closing price of the Companys common stock on the Nasdaq SmallCap Market on January 20, 2004. In addition, warrants to purchase 990,100 shares of the Companys common stock were issued to the institutional investors (See
NOTE 9. Common Stock Warrants).



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



On November 8, 2004, the Company completed the sale of 4,183,422 shares of its common stock, to
unaffiliated institutional investors in a registered direct offering, at a purchase price of $3.45 per share for aggregate proceeds of approximately $13,500,000 after offering expenses ($66,000) and placement agency fees ($866,000). The shares were
offered through a prospectus supplement pursuant to the Companys effective shelf registration statement. The share price represented a 13% discount to the closing price on the Nasdaq SmallCap Market on November 1, 2004.

On September 15, 2005, the Company completed the sale of 11,400,000 shares of its common stock to unaffiliated institutional investors in a
registered direct offering, at a purchase price of $2.15 per share, for aggregate proceeds of approximately $22,942,000 after offering expenses ($97,000) and placement agency fees ($1,471,000). The shares were offered through a prospectus supplement
pursuant to the Companys effective shelf registration statement. The share price represented an 18% discount to the closing price on the Nasdaq SmallCap Market on September 9, 2005. In addition, warrants to purchase 3,420,000 shares of
the Companys common stock were issued to the institutional investors (see NOTE 9. Common Stock Warrants).



|NOTE | 9.  Common Stock Warrants
|---- | -------------------------

In connection with
its August 2000 private placement, the Company granted to the placement agent warrants to purchase 167,166 shares of the Companys common stock at an exercise price of $3.22 per share. These warrants expire on August 17, 2007 and are
subject to adjustment under certain circumstances. Such circumstances include the issuance of shares of common stock by the Company for a consideration per share less than the exercise price of the warrants, and the issuance by the Company of
securities convertible into shares of common stock for which the exercise or conversion price, when added to the purchase price of such convertible securities, is less than the exercise price of the warrants. All such warrants are currently
outstanding and exercisable.

In connection with the execution of an agreement with an investment bank to provide future financing to the
Company, on December 12, 2001, the Company granted to the investment bank two separate warrants to purchase 50,000 shares and 200,000 shares of the Companys common stock at an exercise price of $3.79 per share. The warrant to purchase
50,000 shares is vested. The warrant to purchase 200,000 shares was cancelled without vesting subsequent to December 31, 2001 as a result of the investment banks termination by the Company. The warrant to purchase 50,000 shares of common
stock expires on December 12, 2006. The warrant to purchase 50,000 shares is currently outstanding and exercisable.

In connection
with its April 2002 private placement, the Company granted to the placement agent warrants to purchase 100,000 shares of the Companys common stock at an exercise price of $2.75 per share. When issued, these warrants will be fully exercisable
and have a term of five years from the date of the transaction.

In connection with the May 2003 private placement, the Company granted
warrants to purchase 2,000,000 shares of its common stock at an exercise price of $1.37 per share. These warrants expire on May 23, 2008 and contain certain provisions under which the holder may elect to receive, without the payment by the
holder of any additional consideration, a number of shares of the Companys common stock equal to the value of the warrant, also known as net exercise provisions. Of this total, warrants to purchase 1,500,000 shares were exercisable
immediately. The remaining warrants to purchase 500,000 shares were generally exercisable after 18 months from issuance, or beginning on November 23, 2004, or prior to November 23, 2004 if the holder exercised the warrants on a net
exercise basis. In August 2003, Ziff Asset Management, L.P. exercised its warrants to purchase 600,000 shares of the Companys common stock at an exercise price of $1.37 per share, pursuant to these warrants. Proceeds to the Company from the
exercise of this warrant were $822,000. In October 2003, Biotechnology Value Fund LP and associated entities and Ziff Asset Management, L.P. exercised their warrants to purchase 1,200,000 shares of the Companys common stock under the net
exercise provisions of these warrants resulting in the issuance of 892,361 shares of common stock. In December 2004, Ziff Asset Management, L.P. exercised their remaining warrants to purchase 200,000 shares of the Companys common stock at an
exercise price of $1.37 per share. Proceeds to the Company from the exercise of this warrant were $274,000. As a result of these transactions, no warrants under this grant were outstanding as of December 31, 2005.

In connection with the January 2004 private placement, the Company granted warrants to purchase 990,100 shares of its common stock. The warrants have an
exercise price of $5.38 per share and expire on January 23, 2009.



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



The exercise price and the number of shares that may be purchased upon exercise of the warrants may be adjusted from time to time as a result of a stock
dividend, split or subdivision of shares, as well as a combination of shares or merger or consolidation. All such warrants are currently outstanding and exercisable.

In connection with the September 2005 registered direct offering, the Company granted warrants to purchase 3,420,000 shares of its common stock. The warrants have an exercise price of $3.15 per share, expire on
March 13, 2011 and are exercisable six months after issuance, or beginning on March 13, 2006. The exercise price and the number of shares that may be purchased upon exercise of the warrants may be adjusted from time to time as a result of
a stock dividend, split or subdivision of shares, as well as a combination of shares or merger or consolidation.



|NOTE 10. | Common Stock Options and Restricted Common Stock Awards
|-------- | -------------------------------------------------------

In May 1996, the stockholders approved the amended 1992 Stock Option Plan (the 1992 Plan), which provided for the granting of options for the purchase of up to 2,500,000 shares of common stock. The 1992 Plan expired in May 2002.
In May 1998, the stockholders approved the 1998 Equity Compensation Plan (the 1998 Plan), which provides for the granting of options and stock awards of up to 1,500,000 shares of common stock. In May 2001, the stockholders approved an
amendment to the Companys Amended 1998 Equity Compensation Plan to increase the number of shares of common stock issuable there under to 3,500,000 shares. In May 2004, the stockholders approved the 2004 Stock-Based Incentive Compensation Plan
(the 2004 Plan), which provides for the granting of options and stock awards of up to 4,500,000 shares of common stock.

The
plans provide for the granting of incentive stock options and nonqualified stock options and are administered by a committee of the Companys board of directors. The committee has the authority to determine the term during which an option may
be exercised (provided that no option may have a term of more than ten years), the exercise price of an option and the rate at which options may be exercised. Incentive stock options may be granted only to employees of the Company. Nonqualified
stock options may be granted to employees, directors or consultants of the Company. The exercise price of options under the 1992 Plan, the 1998 Plan and the 2004 Plan cannot be less than the fair market value of the underlying common stock on the
date of the grant.

A summary of the status of the Companys stock options as of December 31, 2005, 2004 and 2003 and changes
during the years then ended, is presented below (in thousands, except per share data):



|                                 |  |        |   |      |                                |      |        |       |   |                                |   |        |  |       |                                |  |   |     
|-------------------------------- |  | ------ | - | ---- | ------------------------------ | ---- | ------ | ----- | - | ------------------------------ | - | ------ |  | ----- | ------------------------------ |  | - | ----
|                                 |  | 2005   |   | 2004 |                                | 2003
|                                 |  | Shares |   |      | Weighted AverageExercise Price |      | Shares |       |   | Weighted AverageExercise Price |   | Shares |  |       | Weighted AverageExercise Price
|Outstanding at beginning of year |  | 4,170  |   |      | $                              | 4.00 |        | 4,038 |   |                                | $ | 3.88   |  | 4,214 |                                |  | $ | 3.77
|Granted                          |  | 2,390  |   |      | $                              | 1.77 |        | 1,380 |   |                                | $ | 3.66   |  | 591   |                                |  | $ | 3.66
|Exercised                        |  | (45    | ) |      | $                              | 0.89 |        | (662  | ) |                                | $ | 2.71   |  | (261  | )                              |  | $ | 2.07
|Forfeited                        |  | (714   | ) |      | $                              | 4.07 |        | (516  | ) |                                | $ | 3.86   |  | (303  | )                              |  | $ | 2.81
|Expired                          |  | (224   | ) |      | $                              | 8.04 |        | (70   | ) |                                | $ | 3.80   |  | (203  | )                              |  | $ | 4.79
|                                 |  |        |   |      |                                |      |        |       |   |                                |   |        |  |       |                                |  |   |     
|Outstanding at end of year       |  | 5,577  |   |      | $                              | 2.90 |        | 4,170 |   |                                | $ | 4.00   |  | 4,038 |                                |  | $ | 3.88
|                                 |  |        |   |      |                                |      |        |       |   |                                |   |        |  |       |                                |  |   |     
|Exercisable at end of year       |  | 2,275  |   |      | $                              | 3.75 |        | 1,984 |   |                                | $ | 4.86   |  | 2,510 |                                |  | $ | 4.74
|                                 |  |        |   |      |                                |      |        |       |   |                                |   |        |  |       |                                |  |   |     

The following table summarizes information about stock options outstanding and exercisable as of
December 31, 2005 (in thousands, except per share data and years):



|                         |  |                     |  |                                           |  |                                |       |                   |       |                                |   |      
|------------------------ |  | ------------------- |  | ----------------------------------------- |  | ------------------------------ | ----- | ----------------- | ----- | ------------------------------ | - | -----
|                         |  | Options Outstanding |  | Options Exercisable                      
|Range of Exercise Prices |  | SharesOutstanding   |  | Weighted AverageRemainingContractual Life |  | Weighted AverageExercise Price |       | SharesExercisable |       | Weighted AverageExercise Price
|$ 0.40 - $ 1.67          |  | 1,813               |  | 8.7 Years                                 |  | $                              | 1.29  |                   | 486   |                                | $ | 0.88 
|$ 1.67 - $ 3.35          |  | 1,753               |  | 7.9 Years                                 |  | $                              | 2.48  |                   | 569   |                                | $ | 2.99 
|$ 3.47 - $ 4.65          |  | 1,619               |  | 7.5 Years                                 |  | $                              | 3.91  |                   | 878   |                                | $ | 3.95 
|$ 5.10 - $ 5.75          |  | 130                 |  | 6.6 Years                                 |  | $                              | 5.25  |                   | 80    |                                | $ | 5.34 
|$ 7.38 - $ 7.94          |  | 97                  |  | 1.5 Years                                 |  | $                              | 7.44  |                   | 97    |                                | $ | 7.44 
|$10.13 - $11.63          |  | 165                 |  | 0.6 Years                                 |  | $                              | 10.78 |                   | 165   |                                | $ | 10.78
|                         |  |                     |  |                                           |  |                                |       |                   |       |                                |   |      
|$ 0.40 - $11.63          |  | 5,577               |  | 7.7 Years                                 |  | $                              | 2.90  |                   | 2,275 |                                | $ | 3.75 
|                         |  |                     |  |                                           |  |                                |       |                   |       |                                |   |      



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



The 1998 Plan provides for the issuance of common stock awards, up to a maximum of 375,000 shares.
The 2004 Plan provides for the issuance of common stock awards with no restriction as to the percentage of shares issued as stock awards in relation to the maximum shares allowable under the plan. Such awards shall be made subject to such
performance requirements, vesting provisions, transfer restrictions or other restrictions and conditions as a committee of the Companys board of directors may determine. Under the 1998 and 2004 Plans, common stock awards canceled are
reissuable. As of December 31, 2005, 574,125 and 101,875 shares have been awarded under the 1998 Plan and 2004 Plan, respectively. The cost of these awards will be recognized as expense over the vesting periods, which range from two to four
years. The following table provides information as of December 31, 2005 regarding the number of restricted stock awards granted, issued, and outstanding.



|              |  |                |  |                  |  |               |  |                
|------------- |  | -------------- |  | ---------------- |  | ------------- |  | ---------------
|Year of Grant |  | Shares Granted |  | Shares Cancelled |  | Shares Issued |  | Shares Unvested
|1998          |  | 146,000        |  | 25,000           |  | 121,000       |  |               
|1999          |  | 32,500         |  | 2,500            |  | 30,000        |  |               
|2000          |  | 27,500         |  | 3,750            |  | 23,750        |  |               
|2003          |  | 95,000         |  | 3,750            |  | 46,250        |  | 45,000         
|2004          |  | 300,000        |  | 50,000           |  | 108,334       |  | 141,666        
|2005          |  | 75,000         |  | 75,000           |  |              |  |               
|              |  |                |  |                  |  |               |  |                
|Total         |  | 676,000        |  | 160,000          |  | 329,334       |  | 186,666        
|              |  |                |  |                  |  |               |  |                

Compensation expense related to these stock awards for the years ended December 31, 2005,
2004 and 2003 was $545,000, $503,000 and $48,000, respectively.

In 2005 and 2004, the Company issued 25,000 and 56,000 shares of the
Companys common stock to consultants. The Company recorded compensation expense for the common stock issued to the consultants of $103,000 and $112,000 for the years ended December 31, 2005 and 2004, respectively.

The Company granted options to purchase 20,000 and 25,000 shares of the Companys common stock to consultants in prior years. The compensation
expense for options granted to the consultants was recognized over the respective service periods ranging up to one year or in accordance with vesting provisions. Compensation expense related to these options for the year ended December 31,
2003 was $35,000. In 2000, 2003 and 2005, the Company entered into consulting contracts with former employees of the Company subsequent to their employment. As a result of these contracts, the former employees retained unvested options to purchase
97,500, 190,000 and 33,750 shares of the Companys common stock, respectively, after their transition to non-employee status. The Company recorded additional compensation expense of $4,000, $32,000 and $128,000 for the years ended
December 31, 2005, 2004 and 2003, respectively related to these options.



|NOTE 11. | Income Taxes
|-------- | ------------

As of December 31, 2005, the
Company has $161,659,000 of net operating loss (NOL) carryforwards for federal income tax purposes (expiring in years 2006 through 2025). In addition, the Company has NOL carryforwards for state income tax purposes of $131,285,000
(expiring in years 2006 through 2025). Pennsylvania has a $2,000,000 annual limitation on the utilization of NOL carryforwards, thus the Company is not likely to utilize most of its state NOL carryforwards. The Company also has $7,536,000 of
research and development tax credits carryforwards available to offset future federal income tax liability (expiring in years 2006 through 2025) and $177,000 of research and development tax credits available to offset future state income tax
liability. The NOL carryforward differs from the accumulated deficit principally due to differences in the recognition of certain expenses between financial and federal tax reporting. As of December 31, 2005, approximately $3,000,000 of the
Companys gross deferred tax assets, for which no tax benefits have been recognized, are attributable to stock option



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



deductions. To the extent that such tax benefits are recognized in the future, the benefit would be credited directly to stockholders equity.

Under the Tax Reform Act of 1986, the utilization of a corporations NOL carryforward and research and development tax credits are
limited following a change in ownership of greater than 50% within a three-year period. Due to the Companys prior equity transactions, the Companys net operating loss and tax credit carryforwards may be subject to an annual limitation
generally determined by multiplying the market value of the Company on the date of the ownership change by the federal long-term tax-exempt rate. Any amount exceeding the annual limitation may be carried forward to future years for the balance of
the NOL and tax credit carryforward period.

Deferred income taxes reflect the net tax effects of temporary differences between carrying
amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes and NOL and tax credit carryforwards. In assessing the realizability of deferred tax assets, management considers whether it is more
likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon generation of future taxable income during the periods in which temporary differences
representing net future deductible amounts become deductible or the NOL and tax credit carryforwards can be utilized. Due to the uncertainty of the Companys ability to realize the benefit of the deferred tax asset, the deferred tax assets are
fully offset by a valuation allowance at December 31, 2005 and 2004. The net change in the valuation allowance for deferred tax assets at December 31, 2005 and 2004 was an increase of $8,444,000 and $8,211,000, respectively. The expected
tax benefit calculated using a federal statutory tax rate of 35% has been reduced to an actual benefit of zero due primarily to the aforementioned valuation allowance.

Significant components of the net deferred tax assets as of December 31, 2005 and 2004 consist of the following (in thousands):



|                                     |  |      |          |   |      |   |         |  
|------------------------------------ |  | ---- | -------- | - | ---- | - | ------- | -
|                                     |  | 2005 |          |   | 2004 |  
|Deferred tax assets:                 |  |      |          |   |      |   |         |  
|Net operating losses                 |  | $    | 65,106   |   |      | $ | 62,152  |  
|Research credits                     |  |      | 7,651    |   |      |   | 6,886   |  
|Capitalized research and development |  |      | 27,457   |   |      |   | 23,849  |  
|Accrued expenses, reserves and other |  |      | 23       |   |      |   | 388     |  
|Depreciation and amortization        |  |      | 2,182    |   |      |   | 700     |  
|                                     |  |      |          |   |      |   |         |  
|Total gross deferred tax assets      |  |      | 102,419  |   |      |   | 93,975  |  
|Valuation allowance                  |  |      | (102,419 | ) |      |   | (93,975 | )
|                                     |  |      |          |   |      |   |         |  
|Deferred tax assets, net             |  | $    |         |   |      | $ |        |  
|                                     |  |      |          |   |      |   |         |  

Reconciliations of the income tax expenses from the federal statutory rates for 2005, 2004 and
2003 are as follows:



|                                        |  |                        |        |   |      |       |   |      |   |        |   |  |       |   |  |   |        |   |  |       |  
|--------------------------------------- |  | ---------------------- | ------ | - | ---- | ----- | - | ---- | - | ------ | - |  | ----- | - |  | - | ------ | - |  | ----- | -
|                                        |  | Year Ended December 31 |       
|                                        |  | 2005                   |        |   | 2004 |       |   | 2003 |  
|Pre-tax book loss                       |  | $                      | (9,226 | ) |      | -35.0 | % |      | $ | (6,256 | ) |  | -35.0 | % |  | $ | (3,288 | ) |  | -35.0 | %
|Adjustments resulting from:             |  |                        |        |   |      |       |   |      |   |        |   |  |       |   |  |   |        |   |  |       |  
|Non-deductible items                    |  |                        | 8      |   |      | 0.0   | % |      |   | 8      |   |  | 0.0   | % |  |   | 3      |   |  | 0.0   | %
|Credits generated during year           |  |                        | (425   | ) |      | -1.6  | % |      |   | (539   | ) |  | -3.0  | % |  |   | (193   | ) |  | -2.0  | %
|Increase in federal valuation allowance |  |                        | 9,643  |   |      | 36.6  | % |      |   | 6,787  |   |  | 38.0  | % |  |   | 3,478  |   |  | 37.0  | %
|                                        |  |                        |        |   |      |       |   |      |   |        |   |  |       |   |  |   |        |   |  |       |  
|Total income tax expense                |  | $                      |       |   |      | 0.0   | % |      | $ |       |   |  | 0.0   | % |  | $ |       |   |  | 0.0   | %
|                                        |  |                        |        |   |      |       |   |      |   |        |   |  |       |   |  |   |        |   |  |       |  



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



|NOTE | 12. Collaborative Arrangements
|---- | ------------------------------

In February
1997, the Company entered into a development, supply and distribution agreement in North America with GlaxoSmithKline for LOCILEX Cream (the GlaxoSmithKline Agreement). GlaxoSmithKline paid the Company $10,000,000 under this agreement.
Because LOCILEX was not approved by the FDA, commercialization did not occur. The GlaxoSmithKline Agreement gives GlaxoSmithKline rights to terminate the arrangement and, under certain conditions, the right to negotiate for rights to another Genaera
product development candidate. GlaxoSmithKline remains the Companys exclusive sales, marketing and distribution partner for the North American territory for LOCILEX Cream.

In April 2001, the Company entered into a research collaboration and licensing agreement with MedImmune, Inc. (MedImmune) to develop and commercialize
therapies related to the Companys IL9 program. MedImmune provided funding of $2,500,000 to the Company for research and development activities at the Company over a two-year period from April 2001 to April 2003 (the R&D
Funding). The R&D Funding was paid in eight quarterly installments and recognized by the Company as revenues on a straight-line basis over the two-year period. By the end of that two-year period, licensed technology had been transferred to
MedImmune and MedImmune assumed responsibility for development and commercialization efforts on the IL9 program. In addition to the R&D Funding, MedImmune agreed to reimburse the Company for certain external costs incurred by the Company in
connection with the IL9 research plan, which will be recognized by the Company as revenues when the related expenses are incurred. In August 2004, the Company received a milestone payment as a result of the initiation of Phase I clinical trials. For
the year ended December 31, 2005, the Company recognized $343,000 of revenue from external cost reimbursements. For the year ended December 31, 2004, the Company recognized $848,000 of revenue from milestone payments ($500,000) and
external cost reimbursements ($348,000). For the year ended December 31, 2003, the Company recognized $701,000 of revenue related to the R&D Funding ($370,000) and external cost reimbursements ($331,000). No revenue related to milestone
payments was recognized during the years ended December 31, 2005 and 2003. The Company could also receive up to $54,500,000 in additional funding based on successful completion of future milestones. The Company is also entitled to royalties on
sales of commercial products resulting from the collaboration. Receipt of future milestones and royalties is dependent upon favorable results in the future from clinical trials being conducted by MedImmune, MedImmune continuing to conduct the
research and development activities required to commercialize the product and the commercial success of the product if and when it is approved for marketing by the United States Food and Drug Administration (FDA).

In September 2001, the Company received a contingent award of up to $1,700,000 from Cystic Fibrosis Foundation Therapeutics (CFFT), an
affiliate of the Cystic Fibrosis Foundation, to support early clinical evaluation of LOMUCIN involving patients with cystic fibrosis. In April 2005, the award was increased to $2,863,000, consisting of $513,000 previously received in
connection with the Companys initial Phase II trial of LOMUCIN and up to $2,350,000 in milestone-driven, matching funds from CFFT to support a pivotal multi-center, randomized, double-blind, placebo-controlled Phase II clinical trial of
LOMUCIN in approximately 200 individuals with cystic fibrosis. Of the total grant of $2,863,000, $1,713,000 of grant support relating to the Phase II clinical evaluation of LOMUCIN was recorded as a long-term liability as of December 31, 2005.
The Company did not recognize this amount as revenue as it is refundable to CFFT upon marketing approval by the FDA or if the Company elects not to enter Phase III clinical trials or not to commercialize the product within two years of the
satisfaction of development milestones, assuming the achievement of statistically significant results. CFFT is also due a royalty of up to 1.6% on net sales of any resultant product, based upon the amount of funding ultimately provided by CFFT.

In February 2002, the Company received a Phase II Small Business Innovative Research (SBIR) program grant from the National
Institutes of Health (NIH) in the amount of $800,000 to support its aminosterol research program. The grant extended over a two-year period, which ended in February 2004. In February 2004, the Company notified the NIH of a no-cost
extension of the original budget period by twelve months. As a result of the notification, the grant was extended to February 2005. The Company recognized $96,000 and $412,000 of revenue related to this grant for the years ended December 31,
2005 and 2003, respectively. The Company recognized no revenue related to this grant in the year ended December 31, 2004.



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GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



In April 2004, the Company received a Phase I SBIR program grant from the National Institute of
Diabetes and Digestive and Kidney Diseases of the NIH in the amount of $100,000 to support its trodusquemine (formerly trodulamine) program. The grant originally extended over a one-year period ending in March 2005. In March 2005, the Company
notified the NIH of a no-cost extension to the original budget period by twelve months. As a result of the notification, the grant was extended to March 2006. The Company recognized no revenue related to this grant during the years ended
December 31, 2005 and December 31, 2004.

In September 2004, the Company received a Phase I SBIR program grant from the National
Eye Institute of the NIH in the amount of $100,000 to support its aminosterols for age-related macular degeneration program. The grant originally extended over a one-year period ending in August 2005. In August 2005, the Company notified the NIH of
a no-cost extension to the original budget period by twelve months. As a result of the notification, the grant was extended to August 2006. The Company recognized no revenue related to this grant during the years ended December 31, 2005 and
December 31, 2004.



|NOTE | 13. 401(k) Plan
|---- | ---------------

The Company maintains a
401(k) retirement plan available to all full-time, eligible employees. Employee contributions are voluntary and are determined on an individual basis, limited to the maximum amount allowable under federal tax regulations. The Company, at its
discretion, may make certain contributions to the plan. No such Company contributions have been made during the years ended December 31, 2005, 2004 or 2003. During 2005, the Company amended its 401(k) retirement plan to match a portion of
employee contributions up to 3% of each employees eligible compensation or a dollar maximum of $2,400 per plan year. The match is effective January 1, 2006 and vests 20% per year of employment.



|NOTE | 14. Fair Value of Financial Instruments
|---- | ---------------------------------------

The
fair value of financial instruments represents the amount at which the instrument could be exchanged in a current transaction between willing parties, other than in a forced sale or liquidation. Cash equivalents, short-term investments and accounts
payable are carried at amounts that reasonably approximate their fair values due to the short-term nature of these instruments.



|NOTE | 15. Commitments and Contingencies
|---- | ---------------------------------

Facility Lease

The Company has entered into an operating lease for its laboratory and corporate office facilities, which expires in December 2007.
Minimum annual rent payments through 2007 are as follows (in thousands):



|                        |  |   |     
|----------------------- |  | - | ----
|Year Ended December 31, |  |  
|2006                    |  | $ | 408 
|2007                    |  |   | 386 
|                        |  |   |     
|                        |  |   | $794
|                        |  |   |     

The lease provides for rent escalations relating to increases in the Consumer Price Index not to
exceed 7% but no less than 3.5%. For the purposes of the above table, the Company has assumed a minimum lease payment escalation of 3.5% for all future periods after November 2004, the lease anniversary date. Rent expense, which includes the cost of
common area maintenance and other building operating expenses paid to the landlord, was $465,000, $441,000 and $460,000 for the years ended December 31, 2005, 2004 and 2003, respectively.

Equipment Leases and Maintenance Contracts

The
Company has entered into multiple operating leases and maintenance contracts for its laboratory and corporate office equipment. Minimum annual lease payments through 2010 are as follows (in thousands):



|                        |  |   |    
|----------------------- |  | - | ---
|Year Ended December 31, |  |  
|2006                    |  | $ | 115
|2007                    |  |   | 94 
|2008                    |  |   | 54 
|2009                    |  |   | 8  
|2010                    |  |   |   
|                        |  |   |    
|                        |  | $ | 271
|                        |  |   |    



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GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



Equipment rental expense was $68,000, $128,000 and $181,000 for the years ended December 31,
2005, 2004 and 2003, respectively.

Employment Agreements

The Company has employment agreements with certain officers and employees. Employees covered under employment contracts who are terminated without cause are entitled to receive continuation of base pay for
periods ranging from six months to twelve months. Continuation of pay for officers will cease upon the attainment of full time employment elsewhere.

During the year ended December 31, 2005, an executive ceased employment with the Company. As a result, the Company recorded $612,000 of compensation expense for the year ended December 31, 2005. In 2004, two
executives ceased employment with the Company. As a result, the Company recorded $460,000 of continuing compensation expense and $194,000 of stock compensation expense for the year ended December 31, 2004.

Manufacturing Agreement

In January 1999 and prior,
the Company entered into several agreements with Abbott Laboratories (Abbott) providing for the purchase of approximately $10,000,000 of bulk drug substance to be used in the manufacturing process for LOCILEX Cream. The Company
renegotiated this agreement with Abbott in September 1999 after the FDA did not approve LOCILEX Cream, paying Abbott $4,200,000 at that time and receiving partial delivery of material. An additional $3,400,000 was due to Abbott and payable if the
Company received in excess of $10,000,000 of additional funds (as defined in the agreement) in any year beginning in 2000, in which case the Company must pay 15% of such excess over $10,000,000 to Abbott. The Company recorded this conditional
obligation as a liability in 1999 at its then estimated present value. As a result of the Companys financing activities during 2000 and 2001 and other cash inflows, $1,392,000 and $480,000 of this liability was payable and paid to Abbott on
March 1, 2001 and 2002, respectively. No portion of the liability was payable to Abbott on March 1, 2003, as the Company did not receive in excess of $10,000,000 of cash inflows during 2002. As a result of the Companys financing
activities and other cash inflows during 2003, $966,000 of the liability was payable and paid to Abbott on March 1, 2004. The remaining amount of $563,000 was payable and paid to Abbott on March 1, 2005 as a result of the Companys
financing activities during the year ended December 31, 2004.

Litigation

On August 4, 2003, a lawsuit was filed against the Company by Perceptive Life Sciences Master Fund, LTD in the United States District Court for the
Eastern District of Pennsylvania alleging the existence and subsequent breaches of certain contractual obligations by the Company in connection with its sale of shares of Series C Preferred Stock in May 2003. The plaintiff was seeking monetary
damages from the Company or a judgment by the court that the Company should specifically perform the terms of an alleged agreement related to such sale. On February 2, 2005, the parties entered into a settlement agreement. The settlement is on
terms that are not material to the Company, and does not constitute an admission of wrongdoing or liability by the Company. On February 28, 2005, the Court entered the parties stipulated order dismissing the lawsuit with prejudice.



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##### Table of Contents

GENAERA CORPORATION

NOTES TO FINANCIAL STATEMENTS



|NOTE | 16. Quarterly Results (Unaudited)
|---- | ---------------------------------

The
following tables contain selected unaudited information for each quarter of the fiscal years ended December 31, 2005 and 2004 (in thousands, except per share amounts). In the fourth quarters of 2005 and 2004, the Company recorded a charge to
compensation expense of $661,000 and $516,000, respectively, relating to bonus awards to officers and employees. The Company believes that the following information reflects all normal recurring adjustments necessary for a fair presentation of the
information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period.



|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|----------------------------------------------------- |  | ------------ | ------ | - | ------------- | - | ------ | ------------ |  | - | ------------- | - |  | - | ------ | -
|                                                      |  | 2005         |       
|                                                      |  | FirstQuarter |        |   | SecondQuarter |   |        | ThirdQuarter |  |   | FourthQuarter |  
|Collaborative research agreement and grant revenues   |  | $            | 146    |   |               | $ | 244    |              |  | $ | 14            |   |  | $ | 42     |  
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Net loss                                              |  | $            | (5,294 | ) |               | $ | (5,692 | )            |  | $ | (7,526        | ) |  | $ | (7,849 | )
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Net loss per sharebasic and diluted                  |  | $            | (.09   | ) |               | $ | (.10   | )            |  | $ | (.13          | ) |  | $ | (.11   | )
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Weighted average shares outstandingbasic and diluted |  |              | 57,130 |   |               |   | 57,191 |              |  |   | 59,210        |   |  |   | 68,677 |  
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|                                                      | 
|                                                      |  | 2004         |       
|                                                      |  | FirstQuarter |        |   | SecondQuarter |   |        | ThirdQuarter |  |   | FourthQuarter |  
|Collaborative research agreement and grant revenues   |  | $            | 136    |   |               | $ | 36     |              |  | $ | 672           |   |  | $ | 29     |  
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Net loss                                              |  | $            | (4,363 | ) |               | $ | (3,957 | )            |  | $ | (4,690        | ) |  | $ | (4,863 | )
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Net loss per sharebasic and diluted                  |  | $            | (.09   | ) |               | $ | (.08   | )            |  | $ | (.09          | ) |  | $ | (.08   | )
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  
|Weighted average shares outstandingbasic and diluted |  |              | 51,027 |   |               |   | 52,396 |              |  |   | 52,607        |   |  |   | 55,303 |  
|                                                      |  |              |        |   |               |   |        |              |  |   |               |   |  |   |        |  



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