**Exhibit10.65**

**AMENDMENT**

**THIS AMENDMENT** is made as ofOctober 23, 2006, and amends the Employment Agreement dated as of April 2,2004, as amended as of February 13, 2006 (collectively the “EmploymentAgreement”), between **DENDRITE INTERNATIONAL,INC.**(“Dendrite”) and **MARK THEILKEN**(“Employee”).  Unless defined in the Amendment, capitalizedterms used in this Amendment will have the meaning set forth in the EmploymentAgreement.

WHEREAS,the Company and the Employee are parties to the Employment Agreement and wishto amend the Employment Agreement; and

WHEREAS,the Company considers it essential to the best interests of its shareholders tofoster the continuous employment of key management;

NOWTHEREFORE, in consideration of the premises and mutual covenants contained inthis Amendment, the Company and the Employee agree as follows:

1.             Section 4(b) of the EmploymentAgreement is deleted and replaced as follows:

If your employment hereunder is terminated by Dendrite for any reasonother than death, Cause (as defined in Exhibit A), or Disability (as defined inExhibit A), you shall be entitled to receive severance payments of your monthlybase salary for 12 months following your employment termination (calculated atthe rate of base salary then being paid to you as of the date of termination)and your Final Annual Target Bonus (as defined below Section 4(g)).  The severance payments to be paid to youunder this Section 4(b) shall be referred to herein as the “Severance Payment.”  The Severance Payment shall be paid to you intwelve consecutive equal monthly payments commencing in the payroll periodfollowing the date you sign the separation agreement described in Section 4(d)below.  No interest shall accrue or bepayable on or with respect to any Severance Payment.  In the event of a termination of youremployment described in this Section 4(b), you shall be provided continued “COBRA”coverage pursuant to Sections 601 et seq. of ERISA under Dendrite’s grouphealth plan.  During the period which youreceive the Severance Payment, your cost of COBRA coverage shall be the same asthe amount paid by employees of Dendrite for the same coverage under Dendrite’sgroup health plan.  Notwithstanding theforegoing, in the event you become re-employed with another employer and becomeeligible to receive health coverage from such employer, the payment of COBRAcoverage by Dendrite as described herein shall cease.  You agree to notify Dendrite of any full-timeemployment that you begin while receiving the Severance Payment.

2.             A new Section 4(g) is added to theEmployment Agreement as follows:

Final Annual Target Bonus means the annual targetbonus established for you in the fiscal year in which your employmentterminates, or, if the annual target bonus has not been established for you insuch fiscal year, then the annual target bonus for the prior fiscal year shallbe used.

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3.             Exceptas expressly modified by this Amendment, all of the terms and conditions of theEmployment Agreement shall remain in full force and effect.

IN WITNESSWHEREOF, the parties have signed this Amendment as of the first date writtenabove.

**DENDRITEINTERNATIONAL, INC.**
|        | By:    | /s/ Christine A. Pellizzari                       |
|--------|--------|---------------------------------------------------|
|   | Name:  | Christine A. Pellizzari                           |
|   | Title: | Sr. Vice President, General Counsel and Secretary |
|   | Date:  | November ___, 2006                                |
|   |   |                                              |
|   |   |                                              |
|   |   | /s/ Mark Theilken                                 |
|   | Name:  | Mark Theilken                                     |
|   | Date:  | November     , 2006           |

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