# Patent

## Title
Method for the production of compounds containing palladium(0)

## Abstract

The present invention relates to a process for preparing a palladium(0) compound, comprising the reaction of a palladium compound with one or more compounds of the general formula I, II or III in the presence of a base:




Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term   (III).

The Palladium(0) compounds are suitable as homogeneous catalysts, as a precursor for preparing homogeneous catalysts, as a precursor for preparing homogeneous catalysts in situ or as a precursor for preparing heterogeneous catalysts.

## Background
The present invention relates to a process for preparing palladium(0) compounds.
In the form of its compounds, palladium finds use as a catalyst in numerous industrial processes.
More than 80% of the industrially produced chemicals are prepared by catalytic processes. Catalytic processes are generally more economically viable and environmentally friendly than corresponding stoichiometric organic reactions. For the attainment of high yields and selectivities in homogeneous catalytic processes, a wide range of ligand systems has to be used, which in turn requires precursor metal compounds having a wide range of uses. This makes clear the need for constant improvement in the catalyst systems and their preparation processes.
For these applications, one possibility is in particular palladium compounds which contain palladium in the 0 oxidation state. In general, palladium(0) compounds are stabilized by compounds which can provide a free electron pair for coordination. This free electron pair may be provided, for example, by an unsaturated hydrocarbon or by heteroatoms such as phosphorus or nitrogen. Stably storable compounds are commercially obtainable principally only in solid form.
However, compounds which are in liquid form are desired in catalysis. This greatly eases their usability. Often, solid compounds are dissolved in a solvent for this purpose, but solutions of solid Pd(0) compounds are usually unstable and have to be used immediately.
In homogeneous catalysis applications, the precursors used are preferably compounds which can be mixed in a simple manner with ligands, for example different phosphines, so as to be able to prepare a wide range of catalysis systems. This is realized, for example, in the case of the Pd(0) compounds stabilized with unsaturated hydrocarbon ligands.
Numerous Pd(0) complexes with unsaturated compounds in the ligands sphere are known and are described, for example, in Wilkinson, Abel “Comprehensive Organometallic Chemistry”, Vol. 6, p. 243ff “Complexes of Palladium(0)”.
Pd(0) compounds stabilized by unsaturated hydrocarbons may be differentiated according to the ligands into complexes stabilized by monodentate and by multidentate (chelating) ligands. An example of a Pd(0) complex stabilized by monodentate hydrocarbon ligands is Pd(ethylene)3, which decomposes at room temperature and under air.
Stabler Pd(0) compounds are obtained by chelating, for example bidentate, unsaturated hydrocarbon ligands such as dienes. Dienes are classified according to the separation of the two diene functions into 1,4-diene ligands, 1,5-diene ligands, 1,6-diene ligands, 1,7-diene ligands, etc.
1,4-Diene-stabilized palladium(0) finds wide use as a ligand, for example, in the form of 1,5-diphenyl-1,4-pentadien-3-one (dba). One description of the synthesis is given by M. F. Rettig et al. in Inorg. Synth., 1990, 28. The product is isolated from the synthesis solution as a sparingly soluble precipitate. The solid is substantially air-stable, but solutions in organic solvents of these compounds decompose within hours (STREM catalogue: “Chemicals for research”, Catalogue No. 19, 2001-2003).
The use of this complex type as a precursor in homogeneous catalysis is described, for example, in U.S. Pat. No. 6,316,380. In EP-A-508 264, Pd(dba)2 substituted by sulphoalkyl groups is used as homogeneous catalyst in C—C coupling.
A known example of Pd(0) stabilized by 1,5-diene ligand is Pd(COD)2. This is synthesized in DE-A-25 55 374 from Pd(COD)Cl2 in the presence of an organometallic compound, for example Li2(COT)(COT=cyclooctatraene), sodium naphthalide or organoaluminium compounds, in solvents having no active protons. The above patent application also describes the synthesis of Pd(C2H4)3 from Pd(COD)2. Pd(COD)2 is an unstable solid which decomposes within hours under atmospheric conditions. This property makes this compound industrially utilizable only to a limited extent.
J. Krause, G. Cestaric, K.-J. Haack, K. Seevogel, W. Storm, K. R. Porschke (J. Am. Chem. Soc. 1999, 121, 9807-9823 and Chem. Commun. 1998, 12, 1291) describe the synthesis of molecularly defined hepta-1,6-diene-, diallyl ether- and tetramethyldivinyldisiloxane-palladium(0), which are examples of Pd(0) stabilized by 1,6-diene ligands. The synthesis follows substantially the route described for Pd(COD)2. Oxygen-free solvents have to be used for the synthesis and the materials have decomposition temperatures close to room temperature.
For application in homogeneous catalysis, 1,6-diene-Pd(0)-phosphine and -carbene complexes have been identified. These compounds exhibit high activities in the industrially used Heck reaction and the Suzuki C—C coupling reaction, and are described by M. G. Andreu, A. Zapf, M. Beller in Chem. Comm., 2000, 245 and in DE-A-100 62 577.
In the prior art, 1,4-diene-stabilized Pd(0) compounds are used industrially. These exhibit sufficient stability, but solutions of these compounds are not storage-stable. 1,5- and 1,6-diene-stabilized Pd(0) compounds are distinctly less stable than the 1,4-diene-stabilized Pd(0) compounds. In all diene-stabilized Pd(0) compounds, it is typically necessary to work under inert gas and with dried solvents having no active protons in order to isolate molecularly defined Pd2(diene)3 or Pd(diene)2 compounds. In addition, highly sensitive organolithium compounds which pose potential health risks are used in the synthesis, which makes industrial-scale utilization costly and inconvenient. For this reason, these compound classes have not been used industrially on a large scale to date.
It is therefore an object of the present invention to provide a novel inexpensive process for preparing palladium(0) compounds. Solutions of these compounds should be substantially stable thermally and toward atmospheric conditions. This enables access to economically viable, versatile, novel precursors for applications in homogeneous catalysis, heterogeneous catalysis and complex chemistry.
In particular, the invention relates to a process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula (I) in the presence of a base:




in which:

each A is independently a CR7R8 radical where one of the A radicals may be oxygen, sulphur, an NR9 group or an SiR10R11 group, or where the A radicals may be a constituent of a 5- to 20-membered ring system,
x is an integer from 2 to 4, and
each R1 to R11 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is a hydrogen atom, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R2 and R3 and/or R5 and R6 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring.
In a further embodiment, the invention relates to a process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula II in the presence of a base:




in which:

n is an integer from 3 to 20,
each R3 to R15 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R13 and R14 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring, and
each R12 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted; in particular an unsubstituted or halogenated-O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R13 and R15.
In yet a further embodiment, the invention relates to a process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula III in the presence of a base:

Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term  (III)

in which

v and w are each independently 0 or an integer of from 1 to 1000 and v+w is from 0 to 1000,
each R16 is independently selected from a hydrogen atom, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted; in particular an unsubstituted or halogenated —O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R17 and R19,
each R17 to R19 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R17 and R19 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring,
each R20 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted in particular an unsubstituted or halogenated —O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R17 and R19, and
each Term radical is independently (R16)2(CR17R18CR19)Si— or (R16)3Si—.
Surprisingly, the above-described processes, unlike the processes known to date, can be carried out at temperatures above 0° C. In addition, the reaction does not have to be carried out with exclusion of air or with dried solvents.
In the palladium(0) compounds, palladium is present as palladium(0). The oxidation state of palladium in the compounds can be determined by known processes, for example by reacting with uncharged ligands (for example phosphines), isolating and characterizing the resulting compound with NMR, or by concentrating the solution by evaporation and determining the oxidation state by means of XPS.
Palladium Compound
The palladium compound used as the starting compound is not particularly restricted. It may be used either in the form of solids or in the form of aqueous or hydrochloric acid solutions. Preference is given to using palladium compounds having palladium in the +2 or +4 oxidation state. Examples thereof are PdX2, PdX4, M2PdX4, M2PdX6, (NH3)2PdX2 and [Pd(NH3)4]X2, where M is a cation (e.g.: a hydrogen atom, an alkali metal (in particular Na+ or K+) or NR*4+ (R*=hydrogen, C1-4alkyl)) and X is an anion (e.g.: halogen (in particular chlorine), NO3−). Particularly preferred palladium compounds are PdCl2, PdCl4, Pd(NO3)2, [Pd(NH3)4]Cl2, (NH3)2PdCl2, H2PdCl4, H2PdCl6, Na2PdCl4, Na2PdCl6, K2PdCl4 and K2PdCl6.
Ligand of the General Formula I
The palladium compound is reacted with one or more compounds of the general formula I




Each A is independently a CR7R8 radical where one of the A radicals may be oxygen, sulphur, an NR9 group or an SiR10R11 group, or where the A radicals may be a constituent of a 5- to 20-membered ring system.

x is an integer of from 2 to 4.
Each R1 to R11 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R2 and R3 and/or R5 and R6 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring.
Examples of heteroatom-containing rings are rings which derive from the following structures: thiophenes, furans, pyrans, pyrroles and the like. Other rings are likewise possible.
In a preferred embodiment, R1 to R6 are each independently hydrogen atoms, C1-4-alkyl radicals or halogenated C1-4-alkyl radicals; R1 to R6 are more preferably hydrogen atoms.
In a further preferred embodiment, R7 and R8 are preferably each independently hydrogen atoms, C1-4-alkyl radicals or halogenated C1-4-alkyl radicals; R7 and R8 are more preferably hydrogen atoms.
In yet a further embodiment, R9 is preferably independently a hydrogen atom, a C1-4-alkyl radical, a halogenated C1-4-alkyl radical, a —C(O)—C1-4 alkyl radical or a halogenated —C(O)—C1-4 alkyl radical.
In a further embodiment, R10 and R11 are each independently selected from a hydroxyl group, a C1-4 alkyl radical, an —O—C1-4 alkyl radical, a halogenated C1-4-alkyl radical or a halogenated —O—C1-4-alkyl radical. R10 and R11 are more preferably each independently a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
R is preferably a hydrogen atom, a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
Halogens refer to fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine. The radicals substituted by them may be mono- or polysubstituted, preferably perhalogenated.
The compounds of the formula I are preferably symmetrical.
In one embodiment, the -(A)x-group is preferably a group of the formula —CH2—X—CH2— and —X— is selected from —O—, —S—, —SiR2—, —NR— and —NC(O)R, where R is a hydrogen atom, a C1-4-alkyl radical, a halogenated C1-4-alkyl radical, an O—C1-4-alkyl radical, a halogenated O—C1-4-alkyl radical, a C1-4-alkenyl radical or an optionally heteroatom-containing C5-6-aryl radical.
Illustrative examples of compounds of the general formula I are 1,5-hexadiene, 1,6-heptadiene and 1,7-octadiene. Further compounds which may serve as illustration are diallyl ether, diallylamine, diallyl-methylamine, diallylethylamine, N-acetyldiallylamine, diallyl sulphide, diallylsilane, diallyldimethylsilane, difurfuryl ether, difurfurylamine, bis(thiophen-2-yl-methyl)amine, difurfuryl sulphide and 1,3-divinyl-benzene.
Ligand of the General Formula II
The present invention further provides a process for preparing a palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula II in the presence of a base:




n is an integer from 3 to 20; n is preferably an integer from 3 to 6.

Each R13 to R15 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R13 and R14 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring.
Examples of heteroatom-containing rings are rings which derive from the following structures: thiophenes, furans, pyrans, pyrroles and the like. Other rings are likewise possible.
In a preferred embodiment, R13 to R15 are each independently hydrogen atoms, C1-4-alkyl radicals or halogenated C1-4-alkyl radicals; R13 to R15 are more preferably hydrogen atoms.
Each R12 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted; in particular an unsubstituted or halogenated —O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical. The substituents are each as defined for R13 to R15. Each R12 is preferably selected independently from a hydroxyl group, a C1-4-alkyl radical, an —O—C1-4-alkyl radical, a halogenated C1-4-alkyl radical or a halogenated —O—C1-4-alkyl radical. Each R12 is more preferably each independently a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
R is preferably a hydrogen atom, a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
Halogens refer to fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine. The radicals substituted with them may be mono- or polysubstituted, preferably perhalogenated.
Ligand of the General Formula III
The present invention also provides a process for preparing a palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula III in the presence of a base:

Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term  (III).

This formula encompasses both compounds in which the [Si(R16)(CR19CR17R18)O] and [Si(R20)2O] units occur in blocks and compounds in which individual [Si(R16)(CR19CR17R18)O] and [Si(R20)2O] units are distributed randomly in the chain. Mixed forms are likewise possible.
v and w are each independently 0 or an integer from 1 to 1000 and v+w is from 0 to 1000. v and w are preferably each independently 0 or an integer from 1 to 100 and v and w is from 0 to 100; more preferably v and w are each independently 0 or an integer from 1 to 20 and v+w is from 0 to 20.
Each R16 is independently selected from a hydrogen atom, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted; in particular an unsubstituted or halogenated —O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical. The substituents are each as defined for R17 and R19. Each R16 is preferably each independently selected from a hydroxyl group, a C1-4-alkyl radical, an —O—C1-4-alkyl radical, a halogenated C1-4-alkyl radical or a halogenated —O—C1-4-alkyl-radical. Each R16 is more preferably each independently an C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
Each R17 to R19 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is an hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R17 and R19 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring.
The examples of heteroatom-containing rings are rings which derive from the following structures: thiophenes, furans, pyrans, pyrroles and the like. Other rings are likewise possible.
In a preferred embodiment, R17 to R19 are each independently hydrogen atoms, halogens, C1-4-alkyl radicals or halogenated C1-4-alkyl radicals; R17 to R19 are more preferably hydrogen atoms.
Each R20 is independently selected from a hydrogen atom, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical (in particular an unsubstituted or halogenated C1-10-alkyl radical), an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted; in particular an unsubstituted or halogenated —O—C1-10-alkyl radical), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical. The substituents are each as defined for R17 and R19. Each R20 is preferably independently selected from a hydrogen atom, a hydroxyl group, a C1-4-alkyl radical, an —O—C1-4-alkyl radical, a halogenated C1-4-alkyl radical or a halogenated —O—C1-4-alkyl radical. Each R20 is more preferably independently a hydrogen atom, a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
Each Term radical is independently (R16)2(CR17R18CR19)Si— or (R16)3Si—. The unsaturated radical is preferably (R16)2(CR17R18CR19)Si—.
R is preferably a hydrogen atom, a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.
Halogens refer to fluorine, chlorine, bromine and iodine, preferably fluorine and chlorine. The radicals substituted with them may be mono- or polysubstituted, preferably perhalogenated.
In a preferred embodiment, w is 0. In this case, the compounds of the general formula (III) have the following form:

Term-O—[Si(R16)(CR19CR17R18)O]v-Term

where R16 to R19, Term and v are each as defined above.

Illustrative examples of compounds of the general formulae II and III are divinyldisiloxane, 1,1,3,3-tetramethyl-1,3-divinyldisiloxane, 1,1,3,3-tetramethyl-1,3-dithien-2-yldisiloxane, 1,1,3,3-tetramethoxy-1,3-divinyldisiloxane, 1,3-dimethyl-1,3-divinyldisiloxane-diol, 1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetra-siloxane and 1,3,5-trimethyl-1,3,5-trivinylcyclo-trisiloxane. Particular preference is given to 1,1,3,3-tetramethyl-1,3-divinyldisiloxane, 1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane and 1,3,5-trimethyl-1,3,5-trivinylcyclotrisiloxane.
It goes without saying that the palladium compound can be reacted with mixtures of the compounds of the general formula I, II and III. In the reaction of the palladium compound with one or more of the compounds of the general formula I, II and III, preference is given to no further ligands in addition to the compounds of the general formula I, II and III during the reaction.
Base
The palladium compound is reacted with one or more compounds of the general formula I, II or III in the presence of a base. In the context of the invention, “base” refers to inorganic and organic (preferably inorganic) bases, but not organometallic bases. The bases should not decompose in water. Suitable bases are, for example, salts of Bronsted acids. Preference is given to using carbonates, hydrogencarbonates, acetates, formates, ascorbates, oxalates and hydroxides. These may be used in the form of their ammonium (NR4+ where R═H or C1-4-alkyl), alkali metal (for example sodium or potassium) and alkaline earth metal salts.
Solvent
The components are reacted typically in a solvent. The solvents are not particularly restricted. Examples of possible solvents are water, alcohols, hydrocarbons (e.g. aromatic hydrocarbons such as benzene and toluene or aliphatic hydrocarbons such as pentane, hexane and heptane), open-chain or cyclic ethers, amides and esters. However, preference is given to water, C1-6 alcohols (e.g. C1-4 alcohols such as methanol, ethanol, propanol and butanol) and C2-6 ethers as solvents. Mixtures of these solvents may likewise be used.
Reducing Agent
In order to accelerate the reaction or achieve very substantial conversion, the reaction may optionally be effected in the presence of a reducing agent. Suitable reducing agents are those which, compared to the palladium compound used, have a lower redox potential under the selected reaction conditions. For example, formic acid and salts thereof, oxalic acid and salts thereof, hydrazine, glucose, ascorbic acid or formaldehyde can be used. Instead of using a separate reducing agent, it is likewise possible to use a solvent which has reducing properties.
Performance of the Process
In one possible embodiment of the process according to the invention, the palladium compound and the compound of the general formula I, II or III is preferably dissolved in a solvent and the base is suspended in the solution. The reactants are reacted with one another. To this end, the reactants are introduced into a reactor and stirred. The reaction may be effected at a temperature of −78° C. to +200° C., preferably of −10° C. to +100° C. and more preferably of 0° C. to +50° C. The pressure is generally 0.1 mbar to 100 bar, preferably 0.2 to 2 bar. Particular preference is given to ambient pressure ±0.2 bar. The reaction time is commonly 5 minutes to 1 week, preferably 5 minutes to 24 hours, more preferably 30 minutes to 24 hours. As mentioned above, it is not necessary to work with exclusion of air, which is particularly advantageous for the industrial-scale application of the process according to the invention.
Based on 1 equivalent of palladium in the form of the compound used, 1 to 100 equivalents, preferably 3 to 100 equivalents, more preferably 8 to 20 equivalents, of the compound of the general formula I, II or III are used. The base is used in an amount of 1 to 100 equivalents preferably of 2 to 100 equivalents, more preferably of 2.5 to 10 equivalents, based on 1 equivalent of palladium. If present, the reducing agent may be added in an amount of 1 to 100 equivalents based on 1 equivalent of palladium. Instead of using a separate reducing agent, it is likewise possible to use a solvent which has reducing properties. In this case, the amount of the reducing agent (solvent) is not particularly restricted, but rather it can be used in any excess based on 1 equivalent of palladium.
The palladium(0) compounds may be used as such after the reaction. However, it is possible to purify and/or to concentrate the solutions before use. Useful purification steps are, for example, the filtering-off of by-products, the drying of the solution (for example over molecular sieves or MgSO4) or the purification over activated carbon. The solution may be concentrated, for example, by distillation.
The palladium(0) compounds prepared by the process according to the invention are also storage-stable and can be handled under air, generally at temperatures up to 30° C., in some cases up to 60° C. and higher. They typically have a metal content of 0.01% by weight to 40% by weight, preferably of 0.01% by weight to 30% by weight, more preferably of 0.01% by weight to 20% by weight, and a total halogen content of not more than 5% by weight, preferably not more than 2% by weight, more preferably not more than 1% by weight.
The palladium(0) compounds may, either alone or as a mixture, be used as a precursor for catalysts for organic chemistry reactions, by mixing them with a ligand, for example phosphines, phosphites, phosphonites, amines, alkenes, thioethers, alkynes or carbenes, each of which may also be generated in situ. This mixture may be used directly as a catalyst, or the resulting complex may be obtained in substance by customary processes from the mixture.
The inventive palladium(0) compounds may, either alone or as a mixture, also be used directly without using additional ligands as a catalyst precursor in organic chemistry reactions.
The examples which follow are intended to further illustrate the invention. However, the invention is not restricted to these illustrative embodiments, but rather is defined by the claims.


EXAMPLES
General Method for the Synthesis of Palladium(0) Compounds
One equivalent of sodium tetrachloropalladate was dissolved in methanol. To this solution were added 8 equivalents of sodium hydrogencarbonate and 10 equivalents of a compound of the general formula I. The solution was stirred for 4 hours. The methanol was distilled off and the residue stirred over a desiccant and activated carbon. The solids were filtered off and the filtrate was concentrated by distillation. Depending on the distillation conditions, stable palladium solutions having palladium contents of 0.01 to 20% by weight were obtained.
According to this method, reaction mixtures were prepared with the di- to tetraenes specified in Table 1.
The palladium and chlorine content was determined by means of ICP-OES after digestion or by Wickbold combustion.
Method for the Synthesis of Phosphine-Diene-Pd(0) Complexes
One palladium equivalent of the palladium solution obtained from the reaction of 1,1,3,3-tetramethyl-1,3-divinyldisiloxane was admixed with one equivalent of a 5% by weight ethereal tricyclohexylphosphine solution. The resulting precipitate is filtered off and dried. The product was identified by means of 1H, 31P and 13C NMR spectroscopy as tricyclohexylphosphine-(1,1,3,3-tetramethyl-1,3-divinyldisiloxane)-Pd(0) complex.










TABLE 1







Pd
Cl



Yield
content
content


Diene component
[%]
[%]
[%]


















Ex. 1
81
7.9
0.11


Diallyl ether


Ex. 2
69
3.3
0.5


1,5-Hexadiene


Ex. 3
78
5.2
0.11


1,7-Octadiene


Ex. 4
84
8.0
0.1


Diallylamine


Ex. 5
87
8.0
0.09


Diallylmethylamine


Ex. 6
91
18.6
0.02


1,1,3,3-Tetramethyl-1,3-divinyl-


disiloxane


Ex. 7
94
2.3
0.03


1,3,5,7-Tetravinyl-1,3,5,7-


tetramethylcyclotetrasiloxane


Ex. 8
91
10.0
0.02


1,3,5,-Trimethyl-1,3,5-trivinylcyclo-


trisiloxane

## Claims

1. Process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula I in the presence of a base:




in which:
each A is independently a CR7R8-radical where one of the A radicals may be oxygen, sulphur, an NR9 group or an SiR10R11 group, or where the A radicals may be a constituent of a 5- to 20-membered ring system,
x is an integer from 2 to 4, and
each R1 to R11 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is a hydrogen atom, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R2 and R3 and/or R5 and R6 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring.

2. Process according to claim 1, wherein x is 3.

3. Process according to claim 1, wherein R1 to R6 are each hydrogen atoms.

4. Process according to claim 1, wherein -(A)x- is a group of the formula —CH2—X—CH2— and —X— is selected from —O—, —S—, —SiR2—, —NR— and —NC(O)R, and R is hydrogen, a C1-4-alkyl radical or a halogenated C1-4-alkyl.

5. Process according to claim 1, wherein the compound of the general formula I is selected from 1,5-hexadiene, 1,6-heptadiene and 1,7-octadiene.

6. Process according to claim 1, wherein the compound of the general formula I is selected from diallyl ether, diallylamine, diallylmethylamine, diallylethylamine, N-acetyldiallylamine, diallyl sulphide, diallylsilane, diallyldimethylsilane, difurfuryl ether, difurfurylamine, bis(thiophen-2-ylmethyl)amine, difurfuryl sulphide and 1,3-divinylbenzene.

7. Process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula II in the presence of a base:




in which:
n is an integer from 3 to 20,
each R13 to R15 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is hydrogen, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R13 and R14 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring, and
each R12 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical, an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R13 and R15.

8. Process according to claim 7, wherein n is an integer from 3 to 6 and each R12 is independently a C1-4-alkyl radical or a halogenated C1-4-alkyl radical.

9. Process for preparing a Palladium(0) compound, comprising reaction of a palladium compound with one or more compounds of the general formula III in the presence of a base:


Term-O—{[Si(R16)(CR19CR17R18)O]v[Si(R20)2O]w}-Term  (III)


in which
v and w are each independently 0 or an integer of from 1 to 1000 and v+w is from 0 to 1000,
each R16 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical, an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R17 and R19,
each R17 to R19 is independently selected from R, OR, halogen, CN, NO2, NR2, C(O)R, C(O)OR, OC(O)R, CONR2, NHCO2R, NHCOR, CH═CH—CO2R, Si(R)3, Si(OR)3, SiR(OR)2, SiR2(OR), SO3R, SO2R, SOR, SR, PR2, POR2, PO3H, PO(OR)2, in which R is a hydrogen atom, a substituted or unsubstituted C1-10-alkyl radical, a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, and the substituents on the alkyl radical or the alkenyl radical are selected from halogen, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, and the substituents on the aryl radical are selected from halogen, C1-10-alkyl, O—C1-10-alkyl, phenyl, O-phenyl, OH, NH2 and halogenated C1-10-alkyl, where R17 and R19 together with the carbon atoms bonded thereto may be a constituent of a 5- to 7-membered, optionally heteroatom-containing ring,
each R20 is independently selected from hydrogen, a hydroxyl group, a substituted or unsubstituted C1-10-alkyl radical, an —O—C1-10-alkyl radical (where the alkyl radical may be substituted or unsubstituted), a substituted or unsubstituted, mono- or polyunsaturated C1-10-alkenyl radical, or a substituted or unsubstituted, optionally heteroatom-containing C5-10-aryl radical, where the substituents are as defined for R17 and R19, and each Term is independently (R16)2(CR17R18CR19)Si— or (R16)3Si—.

10. Process according to claim 9, wherein the compound of the general formula (III) has the general formula:


Term-O—[Si(R16)(CR19CR17R18)O]v-Term


where R16 to R19, Term and v are each as defined in claim 9.

11. Process according to claim 7, wherein the compound of the general formula II or III is selected from divinyldisiloxane, 1,1,3,3-tetramethyl-1,3-divinyldisiloxane, 1,1,3,3-tetramethyl-1,3-dithien-2-yldisiloxane, 1,1,3,3-tetramethoxy-1,3-divinyldisiloxane, 1,3-dimethyl-1,3-divinyldisiloxanediol, 1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane and 1,3,5-trimethyl-1,3,5-trivinylcyclotrisiloxane.

12. Process according to claim 7, wherein the compound of the general formula II or III is selected from 1,1,3,3-tetramethyl-1,3-divinyldisiloxane, 1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane and 1,3,5-trimethyl-1,3,5-trivinylcyclotrisiloxane.

13. Process according to claim 1, wherein the palladium compound is selected from PdX2, PdX4, M2PdX4, M2PdX6, (NH3)2PdX2 and [Pd(NH3)4]X2, where M is a hydrogen atom, an alkali metal or NR*4+ (R*=hydrogen, C1-4-alkyl) and X is a halogen or NO3−.

14. Process according to claim 13, wherein X is chlorine.

15. Process according to claim 1, wherein the reaction is effected in the presence of a solvent or solvent mixture.

16. Process according to claim 15, wherein the solvent is selected from water, C1-6-alcohols and C2-6-ethers and mixtures thereof.

17. Process according to claim 1, wherein the base is selected from alkali metal salts, alkaline earth metal salts and ammonium salts (ammonium as NR4+ where R═H or C1-4-alkyl) of carbonates, hydrogencarbonates and hydroxides.

18. Process according to claim 1, also comprising a purification step.

19. Process according to claim 1, also comprising a concentration step.

20. Process according to claim 1, wherein the reaction of the palladium compound with one or more compounds of the general formula I, II or III is carried out in the presence of one or more ligands other than the compound of the general formula I, II or III.

21. Process according to claim 1, further comprising the reaction of the palladium compound with one or more ligands other than the compound of the general formula I, II or III.

22. Palladium(0) compound obtainable by a process according to claim 7, wherein the compound of the general formula II is 1,3,5,7-tetravinyl-1,3,5,7-tetramethylcyclotetrasiloxane.