EX-10.1




 Exhibit 10.1 

AMENDMENT TO EMPLOYMENT AGREEMENT 

This Amendment to Employment Agreement (“Amendment”) is made between Amylyx Pharmaceuticals, Inc., a Delaware corporation (the
“Company”) and Patrick Yeramian, M.D. (“Executive”) and is effective as of December 1, 2022 (the “Effective Date”). 

WHEREAS, the Company and Executive are parties to that certain Employment Agreement, effective January 11, 2022 (the “Employment
Agreement”); and 
 WHEREAS, the parties wish to amend the Employment Agreement to reflect that Executive will begin working twenty
(20) hours per week as of the Effective Date and will receive a reduced Base Salary; and 
 WHEREAS, all other terms and conditions of
the Employment Agreement will remain effective, and Executive will continue to perform the core duties of the job of Chief Medical Officer. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, the parties agree as follows: 
  

	 	1.	 That Section 1(b) of the Employment Agreement is hereby replaced in its entirety with the following
paragraph: 


 (b) Position and Duties. The Executive shall serve as the Chief Medical Officer of the Company and
shall have such powers and duties as may from time to time be prescribed by the Co-Chief Executive Officers (individually and collectively, the “CEO”) or other duly authorized executive. The Executive shall devote the Executive’s full
working time and efforts to the business and affairs of the Company; provided, however, that Executive’s full working time and efforts shall be twenty (20) hours per week. Notwithstanding the foregoing, the Executive may serve on other
boards of directors, with the approval of the Board of Directors of the Company (the “Board”), or engage in religious, charitable or other community activities as long as such services and activities do not interfere with the
Executive’s performance of the Executive’s duties to the Company. 
  

	 	2.	 That Section 2(a) of the Employment Agreement is hereby replaced in its entirety with the following
paragraph: 


 (a) That Executive’s base salary shall be paid at a rate of $214,000 per year. The Executive’s
base salary shall be subject to periodic review by the Board or the Compensation Committee of the Board (the “Compensation Committee”). The base salary in effect at any given time is referred to herein as “Base
Salary.” The Base Salary shall be payable in a manner that is consistent with the Company’s usual payroll practices for its executive officers. 












	 	3.	 That all other terms and conditions in the Employment Agreement shall remain in full force and effect according
to their respective terms, and nothing contained herein shall be deemed a waiver of any right or abrogation of any obligations existing under the Employment Agreement except to the extent specifically provided for herein. 



 

	 	4.	 Notwithstanding the place where this Amendment may be executed by any of the parties hereto, the parties
expressly agree that all of the terms and provisions hereof shall be construed in accordance with and governed by the laws of the Commonwealth of Massachusetts, without giving effect to the principles of choice or conflicts of laws thereof.



  

	 	5.	 This Amendment may be executed in counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. Signatures on this Amendment may be conveyed by facsimile or other electronic transmission and shall be binding upon the parties so transmitting their signatures. Counterparts with original
signatures shall be provided to the other parties following the applicable facsimile or other electronic transmission; provided, that failure to provide the original counterpart shall have no effect on the validity or the binding nature of this
Amendment. 


 IN WITNESS WHEREOF, the parties have executive this Amendment effective on the Effective 

Date. 
  

	
	AMYLYX PHARMACEUTICALS, INC.
	
	/s/ Joshua Cohen
	By: Joshua Cohen
	Date: Dec 2, 2022


  

	
	EXECUTIVE
	
	/s/ Patrick Yeramian
	Patrick Yeramian, M.D.
	Date: Dec 2, 2022