Exhibit
4.1

     

    NEOPROBE
CORPORATION

    


    SECOND
AMENDED AND RESTATED CERTIFICATE OF DESIGNATIONS,

    VOTING
POWERS, PREFERENCES, LIMITATIONS,

    RESTRICTIONS,
AND RELATIVE RIGHTS OF SERIES A 8%

    CUMULATIVE
CONVERTIBLE PREFERRED STOCK

    


    It is
hereby certified that:

    


    I.           The
name of the corporation is Neoprobe Corporation (the “Corporation”), a
Delaware corporation.

    


    II.          On
December 26, 2007, the Corporation filed a certificate of designations, voting
powers, preferences, limitations, restrictions, and relative rights of shares of
Series A 8% Cumulative Convertible Preferred Stock of the Corporation (the
“Series A Preferred
Stock”) with the Secretary of State of the State of
Delaware.

    


    III.         On
April 30, 2009, the Corporation filed a first amended and restated certificate
of designations, voting powers, preferences, limitations, restrictions, and
relative rights of shares of the Series A Preferred Stock with the Secretary of
State of the State of Delaware.

    


    IV.  
      Pursuant to Section 242 of the General
Corporation Law of the State of Delaware, set forth hereinafter are the second
amended and restated designations, voting powers, preferences, limitations,
restrictions, and relative rights of shares of Series A 8% Cumulative
Convertible Preferred Stock of the Corporation (the “Second Amended and Restated
Designations”), hereinafter designated as contained in a resolution of
the Board of Directors of the Corporation pursuant to a provision of the
Certificate of Incorporation of the Corporation permitting the issuance of said
Series A Preferred Stock by resolution of the Board of Directors.

    


    V.          The
Second Amended and Restated Designations set forth herein were duly adopted in
accordance with Section 242 of the General Corporation Law of the State of
Delaware by: (1) unanimous written action of the Board of Directors of the
Corporation on July 24, 2009; and (2) unanimous written action of the holders of
the Series A Preferred Stock on July 24, 2009.

    


    1. 
           Designation and
Rank.

     

    (a)           Designation.  The
designation of such series of the Corporation’s Preferred Stock shall be the
Series A 8% Cumulative Convertible Preferred Stock, par value $.001 per
share.  The maximum number of shares of Series A Preferred Stock shall
be Three Thousand (3,000) Shares.

     

    (b)           Rank.  The
Series A Preferred Stock shall rank prior to the common stock, par value $.001
per share (the “Common
Stock”), and to all other classes and series of equity securities of the
Company which by their terms do not rank on a parity with or senior to the
Series A Preferred Stock (“Junior
Stock”).  The Series A Preferred Stock shall be subordinate to
and rank junior to all indebtedness of the Company now or hereafter
outstanding.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    2.             Dividends.

     

    (a)        Quarterly
Dividends.  The holders of shares of the Series A Preferred
Stock shall be entitled to receive, out of funds legally available therefor,
dividends at an annual rate equal to 8% of the Liquidation Preference Amount,
whether or not declared.  Accrued and unpaid dividends shall compound
on a quarterly basis, and shall be, except as set forth in Section 2(b) below,
payable in cash.  The Board of Directors may fix a record date for the
determination of holders of shares of Series A Preferred Stock entitled to
receive payment of such dividends, which record date shall not be more than
sixty (60) days prior to the applicable dividend payment date.  The
first such dividend payment shall be due and payable on March 31, 2008, with
subsequent payments due and payable on June 30, September 30, December 31 and
March 31 of each year, provided that the
physical delivery of a certificate representing shares of Common Stock issued in
payment of dividends at any time up to two business days after the relevant
dividend payment date shall be deemed timely delivered.  All accrued
and unpaid dividends, if any, shall be mandatorily paid immediately prior to the
earlier to occur of (i) a liquidation, dissolution or winding up (or deemed
liquidation, dissolution or winding up under Section 4(b) hereof) of the Company
(a “Liquidation”) or (ii)
a Voluntary Conversion pursuant to Section 5 hereof (the “Mandatory Dividend Payment
Date”).

     

    (b)       Payment of
Dividends.  At the option of the Company in compliance with
this Section 2(b), the Company may pay dividends on the Series A Preferred Stock
in registered shares of Common Stock, with each share of Common Stock being
valued for this purpose at 90% of the average VWAP for the five (5) trading days
immediately preceding the date on which such dividend is due and
payable.  Notwithstanding the above, no dividend shall be paid in
Common Stock (i) in connection with a Liquidation, (ii) if such payment would
cause the 4.99% or 9.99% limitations on beneficial ownership set forth in
Section 7 hereof to be exceeded, (iii) unless the shares of Common Stock
received upon such payment shall be freely salable by the recipient pursuant to
a then effective Registration Statement meeting the requirements of the
Registration Rights Agreement, dated on or about December 26, 2007, and as
amended from time to time, by and between the Company and the investors named
therein or (vi) if a default or an Event of Default has occurred and is
continuing under the Purchase Agreement (as defined below) or under the Notes
issued pursuant to the Purchase Agreement, or the Company has failed to comply
with any provision of this Certificate of Designations in any material
respect.  “VWAP” means, for any
date, (i) the daily volume weighted average price of the Common Stock for such
date on the OTC Bulletin Board (or national securities exchange, if applicable)
as reported by Bloomberg Financial L.P. (based on a trading day from 9:30 a.m.
Eastern Time to 4:02 p.m. Eastern Time); (ii) if the Common Stock is not then
listed or quoted on the OTC Bulletin Board (or national securities exchange, if
applicable) and if prices for the Common Stock are then reported in the “Pink
Sheets” published by the Pink Sheets, LLC (or a similar organization or agency
succeeding to its functions of reporting prices), the most recent bid price per
share of the Common Stock so reported; or (iii) in all other cases, the fair
market value of a share of Common Stock as determined by an independent
appraiser selected in good faith by the holder and reasonably acceptable to the
Company.

     

    (c)        Junior Stock
Dividends.  The Company shall not declare or pay any cash
dividends on, or make any other distributions with respect to or redeem,
purchase or otherwise acquire for consideration, any shares of Junior Stock
unless and until all accrued and unpaid dividends on the Series A Preferred
Stock have been paid in full.  In all events, Junior Stock dividends
shall be subject to the restrictions set forth in Section 3(a)
below.

     

    3.             Voting
Rights.

     

    (a)           Class Voting
Rights.  The Series A Preferred Stock shall have the following
class voting rights (in addition to the voting rights set forth in Section 3(b)
and Section 10 hereof).  So long as at least 25% of the shares of the
Series A Preferred Stock issued pursuant to the Purchase Agreement remain
outstanding, the Company shall not, and shall not permit any subsidiary to,
without the affirmative vote or consent of the holders of at least a majority of
the shares of the Series A Preferred Stock outstanding at the time, given in
person or by proxy, either in writing or at a meeting, in which the holders of
the Series A Preferred Stock vote separately as a class: (i) authorize, create,
issue or increase the authorized or issued amount of any class or series of
stock, including but not limited to the issuance of any more shares of
previously authorized Preferred Stock, ranking on a parity with or prior to the
Series A Preferred Stock, with respect to the distribution of assets on
liquidation, dissolution or winding up; (ii) amend, alter or repeal the terms of
the Series A Preferred Stock, whether by merger, consolidation or otherwise, so
as to adversely affect any right, preference, privilege or voting power of the
Series A Preferred Stock; (iii) repurchase, redeem or pay dividends on (whether
in cash, in kind, or otherwise), shares of the Company's Junior Stock; (iv)
amend the Certificate of Incorporation or By-Laws of the Company so as to affect
materially and adversely any right, preference, privilege or voting power of the
Series A Preferred Stock; (v) effect any distribution with respect to Junior
Stock or parity stock; or (vi) reclassify the Company's outstanding
securities.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    (b)           General Voting
Rights.  Except as otherwise set forth herein and except as
otherwise required by Delaware law, the Series A Preferred Stock shall have no
voting rights.  The Common Stock into which the Series A Preferred
Stock is convertible shall, upon issuance, have all of the same voting rights as
other issued and outstanding Common Stock of the Company.

     

    4.             Liquidation
Preference.

     

    (a)           In
the event of the liquidation, dissolution or winding up of the affairs of the
Company, whether voluntary or involuntary, the holders of shares of the Series A
Preferred Stock then outstanding shall be entitled to receive, out of the assets
of the Company, whether such assets are capital or surplus of any nature, an
amount equal to One Thousand Dollars ($1,000.00) per share (the “Liquidation Preference
Amount”) of the Series A Preferred Stock, before any payment shall be
made or any assets distributed to the holders of the Common Stock or any other
Junior Stock.    The liquidation payment with respect to
each outstanding fractional share of Series A Preferred Stock shall be equal to
a ratably proportionate amount of the liquidation payment with respect to each
outstanding share of Series A Preferred Stock.  All payments for which
this Section 4(a) provides shall be in cash, property (valued at its fair market
value as determined by an independent appraiser reasonably acceptable to the
holders of a majority of the Series A Preferred Stock) or a combination
thereof;  provided, however, that no cash shall be paid to holders of
Junior Stock unless each holder of the outstanding shares of Series A Preferred
Stock has been paid in cash the full Liquidation Preference Amount to which such
holder is entitled as provided herein.  After payment of the full
Liquidation Preference Amount to which each holder is entitled, such holders of
shares of Series A Preferred Stock will not be entitled to any further
participation as such in any distribution of the assets of the
Company.

     

    (b)           A
consolidation or merger of the Company with or into any other corporation or
corporations, or a sale of all or substantially all of the assets of the
Company, or the effectuation by the Company of a transaction or series of
transactions in which more than 50% of the voting shares of the Company is
disposed of or conveyed, shall be, at the election of the holders of a majority
of the Series A Preferred Stock, deemed to be a liquidation, dissolution, or
winding up within the meaning of this Section 4.  In the event of the
merger or consolidation of the Company with or into another corporation that is
not treated as a liquidation pursuant to this Section 4(b), the Series A
Preferred Stock shall maintain its relative powers, designations and preferences
provided for herein and no merger shall result inconsistent
therewith.

     

    (c)           Written
notice of any voluntary or involuntary liquidation, dissolution or winding up of
the affairs of the Company, stating a payment date and the place where the
distributable amounts shall be payable, shall be given by mail, postage prepaid,
no less than forty-five (45) days prior to the payment date stated therein, to
the holders of record of the Series A Preferred Stock at their respective
addresses as the same shall appear on the books of the Company.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    5.             Conversion.  The
holder of Series A Preferred Stock shall have the following conversion rights
(the “Conversion Rights”):

     

    (a)           Right to
Convert.  At any time on or after the date of issuance of the
Series A Preferred Stock (the “Issuance Date”), the
holder of any such shares of Series A Preferred Stock may, at such holder’s
option, subject to the limitations set forth in Section 7 herein, elect to
convert (a “Voluntary
Conversion”) all or any portion of the shares of Series A Preferred Stock
held by such person into a number of fully paid and nonassessable shares of
Common Stock equal to the quotient of (i) the Liquidation Preference Amount of
the shares of Series A Preferred Stock being converted thereon divided by (ii)
the Conversion Price (as defined in Section 5(d) below) then in effect as of the
date of the delivery by such holder of its notice of election to
convert.  The Company shall keep written records of the conversion of
the shares of Series A Preferred Stock converted by each holder.  A
holder shall be required to deliver the original certificates representing the
shares of Series A Preferred Stock upon complete conversion of the Series A
Preferred Stock.

     

    (b)           Mechanics of Voluntary
Conversion.  The Voluntary Conversion of Series A Preferred
Stock shall be conducted in the following manner:

     

    (i)     Holder's Delivery
Requirements.  To convert Series A Preferred Stock into full
shares of Common Stock on any date (the “Voluntary Conversion
Date”), the holder thereof shall (A) transmit by facsimile (or otherwise
deliver), for receipt on or prior to 5:00 p.m., Eastern Time on such date, a
copy of a fully executed notice of conversion in the form attached hereto as
Exhibit I  (the “Conversion Notice”),
to the Company, and (B) with respect to the final conversion of shares of Series
A Preferred Stock held by any holder, such holder shall surrender to a common
carrier for delivery to the Company as soon as practicable following such
Conversion Date but in no event later than six (6) business days after such date
the original certificates representing the shares of Series A Preferred Stock
being converted (or an indemnification undertaking with respect to such shares
in the case of their loss, theft or destruction) (the “Preferred Stock
Certificates”).

     

    (ii)    Company's
Response.  Not later than three (3) trading days after any
Voluntary Conversion Date, the Company or its designated transfer agent, as
applicable, shall issue and deliver to the Depository Trust Company (“DTC”)
account on the holder’s behalf via the Deposit Withdrawal Agent Commission
System (“DWAC”) as specified in the Conversion Notice, the number of shares of
Common Stock to which the holder shall be entitled upon such conversion,
registered in the name of the holder or its designee.  In the
alternative, not later than three (3) trading days after any Voluntary
Conversion Date, the Company shall deliver to the applicable holder by express
courier a certificate or certificates which shall be free of restrictive legends
and trading restrictions (other than those required pursuant to the Purchase
Agreement) representing the number of shares of Common Stock being acquired upon
the conversion of this Note (the “Delivery Date”).
Notwithstanding the foregoing to the contrary, the Company or its designated
transfer agent (the “Transfer Agent”),
shall only be obligated to issue and deliver the shares to the DTC on the
holder’s behalf via DWAC (or certificates free of restrictive legends) if such
conversion is in connection with a sale by the holder and the holder has
complied with the applicable prospectus delivery requirements or an exemption
from such registration requirements (each as evidenced by documentation
furnished to and reasonably satisfactory to the Company).  If in the
case of any Conversion Notice such certificate or certificates are not delivered
to or as directed by the applicable holder by the Delivery Date, the holder
shall be entitled by written notice to the Company at any time on or before its
receipt of such certificate or certificates thereafter, to rescind such
conversion, in which event the Company shall immediately return any Preferred
Stock Certificates tendered for conversion, whereupon the Company and the holder
shall each be restored to their respective positions immediately prior to the
delivery of such Conversion Notice, except that any amounts described in
Sections 5(b)(v) shall be payable through the date notice of rescission is given
to the Company.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    (iii)   Dispute
Resolution.  In the case of a dispute as to the arithmetic
calculation of the number of shares of Common Stock to be issued upon
conversion, the Company shall promptly issue to the holder the number of shares
of Common Stock that is not disputed and shall submit the arithmetic
calculations to the holder via facsimile as soon as possible, but in no event
later than two (2) business days after receipt of such holder's Conversion
Notice.  If such holder and the Company are unable to agree upon the
arithmetic calculation of the number of shares of Common Stock to be issued upon
such conversion within one (1) business day of such disputed arithmetic
calculation being submitted to the holder, then the Company shall within one (1)
business day submit via facsimile the disputed arithmetic calculation of the
number of shares of Common Stock to be issued upon such conversion to the
Company’s independent, outside accountant.  The Company shall cause
the accountant to perform the calculations and notify the Company and the holder
of the results no later than seventy-two (72) hours from the time it receives
the disputed calculations.  Such accountant's calculation shall be
binding upon all parties absent manifest error.  The reasonable
expenses of such accountant in making such determination shall be paid by the
Company, in the event the holder's calculation was correct, or by the holder, in
the event the Company’s calculation was correct, or equally by the Company and
the holder in the event that neither the Company's or the holder's calculation
was correct.  The period of time in which the Company is required to
effect conversions or redemptions under this Certificate of Designation shall be
tolled with respect to the subject conversion or redemption pending resolution
of any dispute by the Company made in good faith and in accordance with this
Section 5(b)(iii).

     

    (iv)  Record Holder.  The
person or persons entitled to receive the shares of Common Stock issuable upon a
conversion of the Series A Preferred Stock shall be treated for all purposes as
the record holder or holders of such shares of Common Stock on the Conversion
Date.

     

    (v)   Company's Failure to Timely
Convert.  If within five (5) business days of the Company's
receipt of the Conversion Notice (the “Share Delivery
Period”) the Company shall fail to issue and deliver to a holder the
number of shares of Common Stock to which such holder is entitled upon such
holder's conversion of the Series A Preferred Stock, or failure to deliver
unlegended certificates representing such shares or shares via DWAC if required
pursuant to Section 5(b)(ii) hereof (a “Conversion Failure”),
in addition to all other available remedies which such holder may pursue
hereunder and under the Securities Purchase Agreement among the Company and the
purchasers listed therein (the “Purchase Agreement”)
between the Company and the initial holders of the Series A Preferred Stock, the
Company shall pay additional damages to such holder on each business day after
such third (3rd) business day that such conversion is not timely effected in an
amount equal 0.5% of the product of (A) the sum of the number of shares of
Common Stock not so issued to the holder on a timely basis pursuant to Section
5(b)(ii) and to which such holder is entitled and (B) the Closing Price (as
defined in Section 5(d)(ii) hereof) of the Common Stock on the last possible
date which the Company could have issued such Common Stock to such holder
without violating Section 5(b)(ii).  If the Company fails to pay the
additional damages set forth in this Section 5(b)(v) within five (5) business
days of the date incurred, then such payment shall bear interest at the rate of
2% per month (pro rated for partial months) until such payments are
made.

     

    (c)           [Reserved]

     

    (d)           Conversion
Price.

     

    (i)    The
term “Conversion
Price” shall mean $0.50 per share, subject to adjustment under Section
5(e) hereof.  Notwithstanding any adjustment hereunder, at no time
shall the Conversion Price be greater than the Conversion Price on the Issuance
Date other than pursuant to the second sentence of Section 5(e)(i) in connection
with a reverse stock split effected by the Company.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    (ii)    The
term “Closing
Price” shall mean (i) the last trading price per share of the Common
Stock on such date on the OTC Bulletin Board or a registered national stock
exchange on which the Common Stock is then listed, or if there is no such price
on such date, then the last trading price on such exchange or quotation system
on the date nearest preceding such date, or (ii) if the price of the Common
Stock is not then reported by the OTC Bulletin Board or a registered national
securities exchange, then the average of the “Pink Sheet” quotes for the
relevant date, as reported by the National Quotation Bureau, Inc., or (iii) if
the Common Stock is not then publicly traded the fair market value of a share of
Common Stock as mutually determined by the Company and the holders of a majority
of the outstanding shares of Series A Preferred Stock.

     

    (e)           Adjustments of Conversion
Price.

     

    (i)     Adjustments for Stock Splits and
Combinations.  If the Company shall at any time or from time to
time after the Issuance Date, effect a stock split of the outstanding Common
Stock, the Conversion Price shall be proportionately decreased.  If
the Company shall at any time or from time to time after the Issuance Date,
combine the outstanding shares of Common Stock, the Conversion Price shall be
proportionately increased.  Any adjustments under this Section 5(e)(i)
shall be effective at the close of business on the date the stock split or
combination occurs.

     

    (ii)    Adjustments for Certain Dividends
and Distributions.  If the Company shall at any time or from
time to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in shares of Common Stock, then, and in each event, the
Conversion Price shall be decreased as of the time of such issuance or, in the
event such record date shall have been fixed, as of the close of business on
such record date, by multiplying, as applicable, the Conversion Price then in
effect by a fraction:

     

    (A)           the
numerator of which shall be the total number of shares of Common Stock issued
and outstanding immediately prior to the time of such issuance or the close of
business on such record date; and

     

    (B)           the
denominator of which shall be the total number of shares of Common Stock issued
and outstanding immediately prior to the time of such issuance or the close of
business on such record date plus the number of shares of Common Stock issuable
in payment of such dividend or distribution.

     

    (iii)  
Adjustment for Other Dividends
and Distributions.  If the Company shall at any time or from
time to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in securities of the Company other than shares of Common
Stock, then, and in each event, an appropriate revision to the applicable
Conversion Price shall be made and provision shall be made (by adjustments of
the Conversion Price or otherwise) so that the holders of Series A Preferred
Stock shall receive upon conversions thereof, in addition to the number of
shares of Common Stock receivable thereon, the number of securities of the
Company which they would have received had their Series A Preferred Stock been
converted into Common Stock immediately prior to such event (or the record date
for such event, if applicable) (without giving effect to the limitations set
forth in Section 7 hereof) and had thereafter, during the period from the date
of such event to and including the Conversion Date, retained such securities
(together with any distributions payable thereon during such period), giving
application to all adjustments called for during such period under this Section
5(e)(iii) with respect to the rights of the holders of the Series A Preferred
Stock; provided,
however, that if such record date shall have been fixed and such dividend
is not fully paid or if such distribution is not fully made on the date fixed
therefor, the Conversion Price shall be adjusted pursuant to this paragraph as
of the time of actual payment of such dividends or
distributions.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    (iv)  Adjustments for Reclassification,
Exchange or Substitution.  If the Common Stock issuable upon
conversion of the Series A Preferred Stock at any time or from time to time
after the Issuance Date shall be changed to the same or different number of
shares of any class or classes of stock, whether by reclassification, exchange,
substitution or otherwise (other than by way of a stock split or combination of
shares or stock dividends provided for in Sections 5(e)(i), (ii) and (iii), or a
reorganization, merger, consolidation, or sale of assets provided for in Section
5(e)(v)), then, and in each event, an appropriate revision to the Conversion
Price shall be made and provisions shall be made (by adjustments of the
Conversion Price or otherwise) so that the holder of each share of Series A
Preferred Stock shall have the right thereafter to convert such share of Series
A Preferred Stock into the kind and amount of shares of stock and other
securities receivable upon reclassification, exchange, substitution or other
change, by holders of the number of shares of Common Stock into which such share
of Series A Preferred Stock might have been converted immediately prior to such
reclassification, exchange, substitution or other change (without giving effect
to the limitations set forth in Section 7 hereof), all subject to further
adjustment as provided herein.

     

    (v)   Adjustments for Reorganization,
Merger, Consolidation or Sales of Assets.  If at any time or
from time to time after the Issuance Date there shall be a capital
reorganization of the Company (other than by way of a stock split or combination
of shares or stock dividends or distributions provided for in Section 5(e)(i),
(ii) and (iii), or a reclassification, exchange or substitution of shares
provided for in Section 5(e)(iv)), or a merger or consolidation of the Company
with or into another corporation, or the sale of all or substantially all of the
Company's properties or assets to any other person that is not deemed a
liquidation pursuant to Section 4(b) (an “Organic Change”),
then as a part of such Organic Change an appropriate revision to the Conversion
Price shall be made and provision shall be made (by adjustments of the
Conversion Price or otherwise) so that the holder of each share of Series A
Preferred Stock shall have the right thereafter to convert such share of Series
A Preferred Stock into the kind and amount of shares of stock and other
securities or property of the Company or any successor corporation resulting
from the Organic Change as the holder would have received as a result of the
Organic Change and if the holder had converted its Series A Preferred Stock into
the Company’s Common Stock prior to the Organic Change (without giving effect to
the limitations set forth in Section 7 hereof).  In any such case,
appropriate adjustment shall be made in the application of the provisions of
this Section 5(e)(v) with respect to the rights of the holders of the Series A
Preferred Stock after the Organic Change to the end that the provisions of this
Section 5(e)(v) (including any adjustment in the Conversion Price then in effect
and the number of shares of stock or other securities deliverable upon
conversion of the Series A Preferred Stock) shall be applied after that event in
as nearly an equivalent manner as may be practicable.

     

    (vi)               [Reserved]

     

    (vii)              [Reserved]

     

    (viii)             [Reserved]


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    (ix)   Record Date.  In
case the Company shall take record of the holders of its Common Stock or any
other Preferred Stock for the purpose of entitling them to subscribe for or
purchase Common Stock or Convertible Securities, then the date of the issue or
sale of the shares of Common Stock shall be deemed to be such record
date.

     

    (f)           No
Impairment.  The Company shall not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Company, but will at all
times in good faith, assist in the carrying out of all the provisions of this
Section 5 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Series A Preferred Stock against impairment.

     

    (g)           Certificates as to
Adjustments.  Upon occurrence of each adjustment or
readjustment of the Conversion Price or number of shares of Common Stock
issuable upon conversion of the Series A Preferred Stock pursuant to this
Section 5, the Company at its expense shall promptly compute such adjustment or
readjustment in accordance with the terms hereof and furnish to each holder of
such Series A Preferred Stock a certificate setting forth such adjustment and
readjustment, showing in detail the facts upon which such adjustment or
readjustment is based.  The Company shall, upon written request of the
holder of such affected Series A Preferred Stock, at any time, furnish or cause
to be furnished to such holder a like certificate setting forth such adjustments
and readjustments, the Conversion Price in effect at the time, and the number of
shares of Common Stock and the amount, if any, of other securities or property
which at the time would be received upon the conversion of a share of such
Series A Preferred Stock.  Notwithstanding the foregoing, the Company
shall not be obligated to deliver a certificate unless such certificate would
reflect an increase or decrease of at least one percent (1%) of such adjusted
amount.

     

    (h)           Issue
Taxes.  The Company shall pay any and all issue and other
taxes, excluding federal, state or local income taxes, that may be payable in
respect of any issue or delivery of shares of Common Stock on conversion of
shares of Series A Preferred Stock pursuant
thereto;  provided,  however, that the Company shall not be
obligated to pay any transfer taxes resulting from any transfer requested by any
holder in connection with any such conversion.

     

    (i)           Notices.  Any
notice, demand, request, waiver or other communication required or permitted to
be given hereunder shall be in writing and shall be effective (i) upon hand
delivery, telecopy or facsimile at the address or number designated in the
Purchase Agreement (if delivered on a business day during normal business hours
where such notice is to be received), or the first business day following such
delivery (if delivered other than on a business day during normal business hours
where such notice is to be received) or (ii) on the second business day
following the date of mailing by express overnight courier service, fully
prepaid, addressed to such address, or upon actual receipt of such mailing,
whichever shall first occur. The Company will give written notice each holder of
Series A Preferred Stock at least ten (10) days prior to the date on which the
Company takes a record (A) with respect to any dividend or distribution upon the
Common Stock, (B) with respect to any pro rata subscription offer to holders of
Common Stock or (C) for determining rights to vote with respect to any Organic
Change, dissolution, liquidation or winding-up and in no event shall such notice
be provided to such holder prior to such information being made known to the
public. The Company will also give written notice to each holder of Series A
Preferred Stock at least ten (10) days prior to the date on which any Organic
Change or Liquidation will take place and in no event shall such notice be
provided to such holder  prior to such information being made known to
the public


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    (j)           Fractional
Shares.  No fractional shares of Common Stock shall be issued
upon conversion of the Series A Preferred Stock.  In lieu of any
fractional shares to which the holder would otherwise be entitled, the Company
shall at its option either (i) pay cash equal to the product of such fraction
multiplied by the average of the Closing Prices of the Common Stock for the five
(5) consecutive trading days immediately preceding the Voluntary Conversion
Date, or (ii) in lieu of issuing such fractional shares issue one additional
whole share to the holder.

     

    (k)           Reservation of Common
Stock.  The Company shall, so long as any shares of Series A
Preferred Stock are outstanding, reserve and keep available out of its
authorized and unissued Common Stock, solely for the purpose of effecting the
conversion of the Series A Preferred Stock, such number of shares of Common
Stock as shall from time to time be sufficient to effect the conversion of all
of the Series A Preferred Stock then outstanding (without regard to the
limitations on conversion set forth in Section 7 hereof).  The initial
number of shares of Common Stock reserved for conversions of the Series A
Preferred Stock and each increase in the number of shares so reserved shall be
allocated pro rata among the holders of the Series A Preferred Stock based on
the number of shares of Series A Preferred Stock held by each holder at the time
of issuance of the Series A Preferred Stock or increase in the number of
reserved shares, as the case may be.  In the event a holder shall sell
or otherwise transfer any of such holder's shares of Series A Preferred Stock,
each transferee shall be allocated a pro rata portion of the number of reserved
shares of Common Stock reserved for such transferor.  Any shares of
Common Stock reserved and which remain allocated to any person or entity which
does not hold any shares of Series A Preferred Stock shall be allocated to the
remaining holders of Series A Preferred Stock, pro rata based on the number of
shares of Series A Preferred Stock then held by such holder.

     

    (l)           Retirement of Series A
Preferred Stock.  Conversion of Series A Preferred Stock shall
be deemed to have been effected on the applicable Voluntary Conversion
Date.  The Company shall keep written records of the conversion of the
shares of Series A Preferred Stock converted by each holder.  A holder
shall be required to deliver the original certificates representing the shares
of Series A Preferred Stock upon complete conversion of the Series A Preferred
Stock.

     

    (m)           Regulatory
Compliance.  If any shares of Common Stock to be reserved for
the purpose of conversion of Series A Preferred Stock require registration or
listing with or approval of any governmental authority, stock exchange or other
regulatory body under any federal or state law or regulation or otherwise before
such shares may be validly issued or delivered upon conversion, the Company
shall, at its sole cost and expense, in good faith and as expeditiously as
possible, endeavor to secure such registration, listing or approval, as the case
may be.

     

    6.             No Preemptive
Rights.  Except as provided in Section 5 hereof, no holder of
the Series A Preferred Stock shall be entitled to rights to subscribe for,
purchase or receive any part of any new or additional shares of any class,
whether now or hereinafter authorized, or of bonds or debentures, or other
evidences of indebtedness convertible into or exchangeable for shares of any
class, but all such new or additional shares of any class, or any bond,
debentures or other evidences of indebtedness convertible into or exchangeable
for shares, may be issued and disposed of by the Board of Directors on such
terms and for such consideration (to the extent permitted by law), and to such
person or persons as the Board of Directors in their absolute discretion may
deem advisable.

     

    7.             Conversion
Restriction.

     

    (a)           
Notwithstanding anything to the contrary set forth in Section 5 of this
Certificate of Designation, at no time may a holder of shares of Series A
Preferred Stock convert shares of the Series A Preferred Stock if the number of
shares of Common Stock to be issued pursuant to such conversion would exceed,
when aggregated with all other shares of Common Stock owned by such holder at
such time, the number of shares of Common Stock which would result in such
holder owning more than 4.99% of all of the Common Stock outstanding at such
time;  provided,  however,
that upon a holder of Series A Preferred Stock  providing the Company
with sixty-one (61) days notice (pursuant to Section 5(i) hereof) (the “Waiver Notice”) that
such holder would like to waive Section 7(a) of this Certificate of Designation
with regard to any or all shares of Common Stock issuable upon conversion of
Series A Preferred Stock, this Section 7(a) shall be of no force or effect with
regard to those shares of Series A Preferred Stock referenced in the Waiver
Notice.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    (b)           
Notwithstanding anything to the contrary set forth in Section 5 of this
Certificate of Designation, at no time may a holder of shares of Series A
Preferred Stock convert shares of the Series A Preferred Stock if the number of
shares of Common Stock to be issued pursuant to such conversion would exceed,
when aggregated with all other shares of Common Stock owned by such holder at
such time, the number of shares of Common Stock which would result in such
holder beneficially owning (as determined in accordance with Section 13(d) of
the Securities Exchange Act of 1934, as amended, and the rules thereunder) in
excess of 9.99% of all of the Common Stock outstanding at such
time;  provided,
however, that upon a holder of Series A Preferred
Stock  providing the Company with sixty-one (61) days notice (pursuant
to Section 5(i) hereof) (the “Waiver Notice”) that
such holder would like to waive Section 7 of this Certificate of Designation
with regard to any or all shares of Common Stock issuable upon conversion of
Series A Preferred Stock, this Section 7 shall be of no force or effect with
regard to those shares of Series A Preferred Stock referenced in the Waiver
Notice.

     

    8.             Inability to Fully
Convert.

     

    (a)           Holder's Option if Company
Cannot Fully Convert.  If, upon the Company's receipt of a
Conversion Notice, the Company cannot issue shares of Common Stock registered
for resale (to the extent the Company was obligated to register such shares
under the Registration Rights Agreement) for any reason, including, without
limitation, because the Company (i) does not have a sufficient number of shares
of Common Stock authorized and available, (ii) is otherwise prohibited by
applicable law or by the rules or regulations of any stock exchange, interdealer
quotation system or other self-regulatory organization with jurisdiction over
the Company or its securities from issuing all of the Common Stock which is to
be issued to a holder of Series A Preferred Stock pursuant to a Conversion
Notice or (iii) fails to have a sufficient number of shares of Common Stock
registered for resale required under the Registration Statement (subject to the
limitations set forth in the Registration Rights Agreement relating to Rule 415
under the Securities Act), then the Company shall issue as many shares of Common
Stock as it is able to issue in accordance with such holder's Conversion Notice
and pursuant to Section 5(b)(ii) above and, with respect to the unconverted
Series A Preferred Stock, the holder, solely at such holder's option, can elect
to:

     

    (i) In
the case of 8(a)(i) above, require the Company to redeem from such holder those
Series A Preferred Stock for which the Company is unable to issue Common Stock
in accordance with such holder's Conversion Notice (“Mandatory
Redemption”) at a price per share equal to 120% of the Liquidation
Preference Amount as of such Conversion Date (the “Mandatory Redemption
Price”);

     

    (ii) if
the Company's inability to fully convert Series A Preferred Stock is pursuant to
Section 8(a)(iii) above, require the Company to issue restricted shares of
Common Stock in accordance with such holder's Conversion Notice and pursuant to
Section 5(b)(ii) above;

     

    (iii)
void its Conversion Notice and retain or have returned, as the case may be, the
shares of Series A Preferred Stock that were to be converted pursuant to such
holder's Conversion Notice (provided that a holder's voiding its Conversion
Notice shall not effect the Company's obligations to make any payments which
have accrued prior to the date of such notice).


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    (b)           Mechanics of Fulfilling
Holder's Election.  The Company shall immediately send via
facsimile to a holder of Series A Preferred Stock, upon receipt of a facsimile
copy of a Conversion Notice from such holder which cannot be fully satisfied as
described in Section 8(a) above, a notice of the Company's inability to fully
satisfy such holder's Conversion Notice (the “Inability to Fully Convert
Notice”).  Such Inability to Fully Convert Notice shall
indicate (i) the reason why the Company is unable to fully satisfy such holder's
Conversion Notice, (ii) the number of Series A Preferred Stock which cannot be
converted and (iii) the applicable Mandatory Redemption Price.  Such
holder shall notify the Company of its election pursuant to Section 8(a) above
by delivering written notice via facsimile to the Company (“Notice in Response to
Inability to Convert”).

     

    (c)           Payment of Redemption
Price.  If such holder shall elect to have its shares redeemed
pursuant to Section 8(a)(i) above, the Company shall pay the Mandatory
Redemption Price to such holder within thirty (30) days of the Company's receipt
of the holder's Notice in Response to Inability to Convert,
provided  that prior to the Company's receipt of the holder's Notice
in Response to Inability to Convert the Company has not delivered a notice to
such holder stating, to the satisfaction of the holder, that the event or
condition resulting in the Mandatory Redemption has been cured and all
Conversion Shares issuable to such holder can and will be delivered to the
holder in accordance with the terms of Section 2(g).  If the Company
shall fail to pay the applicable Mandatory Redemption Price to such holder on a
timely basis as described in this Section 8(c) (other than pursuant to a dispute
as to the determination of the arithmetic calculation of the Redemption Price),
in addition to any remedy such holder of Series A Preferred Stock may have under
this Certificate of Designation and the Purchase Agreement, such unpaid amount
shall bear interest at the rate of 1.5% per month (prorated for partial months)
until paid in full.  Until the full Mandatory Redemption Price is paid
in full to such holder, such holder may (i) void the Mandatory Redemption with
respect to those Series A Preferred Stock for which the full Mandatory
Redemption Price has not been paid, (ii) receive back such Series A Preferred
Stock, and (iii) require that the Conversion Price of such returned Series A
Preferred Stock be adjusted to the lesser of (A) the Conversion Price and (B)
the lowest Closing Price during the period beginning on the Conversion Date and
ending on the date the holder voided the Mandatory Redemption.

     

    9.             Pro-rata Conversion and
Redemption.  In the event the Company receives a Conversion
Notice from more than one holder of Series A Preferred Stock on the same day and
the Company can convert and redeem some, but not all, of the Series A Preferred
Stock pursuant to Section 8, the Company shall convert and redeem from each
holder of Series A Preferred Stock electing to have Series A Preferred Stock
converted and redeemed at such time an amount equal to such holder's pro-rata
amount (based on the number shares of Series A Preferred Stock held by such
holder relative to the number shares of Series A Preferred Stock outstanding) of
all shares of Series A Preferred Stock being converted and redeemed at such
time.

     

    10.           Vote to Change the Terms of
or Issue Preferred Stock.  The affirmative vote at a meeting
duly called for such purpose or the written consent without a meeting, of the
holders of not less than a majority of the then outstanding shares of Series A
Preferred Stock, shall be required (a) for any change to this Certificate of
Designation or the Company’s Certificate of Incorporation that would amend,
alter, change or repeal any of the powers, designations, preferences and rights
of the Series A Preferred Stock or (b) for the issuance of shares of Series A
Preferred Stock other than pursuant to the Purchase Agreement.  The
provisions hereof may be waived on behalf of all the Holders if in writing and
signed by the Holders of not less than a majority of the then outstanding shares
of Series A Preferred Stock.

     

    11.           Lost or Stolen
Certificates.  Upon receipt by the Company of evidence
satisfactory to the Company of the loss, theft, destruction or mutilation of any
Preferred Stock Certificates representing the shares of Series A Preferred
Stock, and, in the case of loss, theft or destruction, of any indemnification
undertaking by the holder to the Company and, in the case of mutilation, upon
surrender and cancellation of the Preferred Stock Certificate(s), the Company
shall execute and deliver new preferred stock certificate(s) of like tenor and
date.


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    

     

    12.           Remedies, Characterizations,
Other Obligations, Breaches and Injunctive Relief.  The
remedies provided in this Certificate of Designation shall be cumulative and in
addition to all other remedies available under this Certificate of Designation,
at law or in equity (including a decree of specific performance and/or other
injunctive relief), no remedy contained herein shall be deemed a waiver of
compliance with the provisions giving rise to such remedy and nothing herein
shall limit a holder's right to pursue actual damages for any failure by the
Company to comply with the terms of this Certificate of
Designation.  Amounts set forth or provided for herein with respect to
payments, conversion and the like (and the computation thereof) shall be the
amounts to be received by the holder thereof and shall not, except as expressly
provided herein, be subject to any other obligation of the Company (or the
performance thereof).  The Company acknowledges that a breach by it of
its obligations hereunder will cause irreparable harm to the holders of the
Series A Preferred Stock and that the remedy at law for any such breach may be
inadequate.  The Company therefore agrees that, in the event of any
such breach or threatened breach, the holders of the Series A Preferred Stock
shall be entitled, in addition to all other available remedies, to an injunction
restraining any breach, without the necessity of showing economic loss and
without any bond or other security being required.

     

    13.        
  Failure or
Indulgence Not Waiver.  No failure or delay on the part of a
holder of Series A Preferred Stock in the exercise of any power, right or
privilege hereunder shall operate as a waiver thereof, nor shall any single or
partial exercise of any such power, right or privilege preclude other or further
exercise thereof or of any other right, power or privilege.

    


    [Signature
Page Follows]


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    IN WITNESS WHEREOF, the undersigned has
executed and subscribed this Second Amended and Restated Certificate and does
affirm the foregoing as true this 24th day of July, 2009.

    


    
      
        	 
      	
                NEOPROBE
      CORPORATION

              
	 
      	 
      	 
      
	 
      	
                By:  

              	
                /s/ Brent L. Larson

              
	 
      	
                Name:
      Brent L. Larson

              
	 
      	
                Title:
      Vice President, Finance /
CFO

              


      

    


    
      
         


      

      
        
        

        
          

        

      

      
         


      

    


    EXHIBIT
I

    NEOPROBE
CORPORATION

    CONVERSION
NOTICE

    


    Reference is made to the Second Amended
and Restated Certificate of Designation of the Relative Rights and Preferences
of the Series A Preferred Stock of Neoprobe Corporation (the “Certificate of
Designation”).  In accordance with and pursuant to the
Certificate of Designation, the undersigned hereby elects to convert the number
of shares of Series A Preferred Stock, par value $.001 per share (the “Preferred Shares”),
of Neoprobe Corporation, a Delaware corporation (the “Company”), indicated
below into shares of Common Stock, par value $.001 per share (the “Common Stock”), of
the Company, by tendering the stock certificate(s) representing the share(s) of
Preferred Shares specified below as of the date specified below.

    


    Date of
Conversion:                                                                        

    


    Number of
Preferred Shares to be converted:                                                                                                       

    


    Stock
certificate no(s). of Preferred Shares to be converted:                                                         

    


    The
Common Stock have been sold pursuant to the Registration Statement (as defined
in the Registration Rights Agreement): YES ____NO____

    


    Please
confirm the following information:

    


    Conversion
Price:                                   

    


    Number of
shares of Common Stock

    to be
issued:                                                            
 

    


    Number of
shares of Common Stock beneficially owned or deemed beneficially owned by the
Holder on the Date of Conversion determined in accordance with Section 16 of the
Securities Exchange Act of 1934, as amended:                                                   
      

    


    Please
issue the Common Stock into which the Preferred Shares are being converted and,
if applicable, any check drawn on an account of the Company in the following
name and to the following address:

    


                Issue
to:                                                                               

                Facsimile
Number:                                                              

     

    Authorization:                                           

                          By:                                                            
              
                    

                          Title:                                                                           

    


    Dated: