EX-10.2



 Exhibit 10.2 

AMENDMENT TO EXCLUSIVE CHANNEL COLLABORATION
AGREEMENT 
 This AMENDMENT TO THE EXCLUSIVE
CHANNEL COLLABORATION AGREEMENT (the “Amendment”) is effective as of June 29, 2016 (the “Amendment Effective Date”) by and between
INTREXON CORPORATION, a Virginia corporation with offices at 20374 Seneca Meadows Parkway, Germantown, MD 20876 (“Intrexon”) and ZIOPHARM ONCOLOGY,
INC., a Delaware corporation having its principal place of business at 1180 Avenue of the Americas, 19th Floor, New York, NY 10036 (“ZIOPHARM”). Intrexon
and ZIOPHARM may be referred to herein individually as a “Party” and collectively as the “Parties.” 

RECITALS 

A. WHEREAS Intrexon and ZIOPHARM are parties to that certain Exclusive Channel Collaboration Agreement, effective
September 28, 2015 (the “Agreement”), pursuant to which Intrexon appointed ZIOPHARM as its exclusive channel collaborator for developing and commercializing certain products for the prevention or treatment Graft vs Host
Disease in humans; and 
 B. WHEREAS the Parties now mutually desire to amend the Agreement; 

D. NOW, THEREFORE, the Parties agree to amend the terms of the Agreement as provided below, effective as
of the Amendment Effective Date. 
  

	1.	GENERALLY 

 1.1 Capitalized terms present within this Amendment
that are not proper names or titles, that are nor conventionally capitalized, or that are not otherwise defined within this Amendment shall have the meaning set forth in the Agreement (as previously amended).  

1.2 The Parties, in conjunction with and contemporaneously with this Amendment, have entered into Preferred
Stock Purchase Agreement of even date herewith (the “Preferred Stock Agreement”). 
  

	2.	AMENDMENT TO THE AGREEMENT 


2.1 Profit Sharing on ZIOPHARM Sales. All references to “fifty percent (50%)” in Section 5.2(a) of the Agreement are
hereby amended to now read “twenty percent (20%)”. For clarity, Section 5.2(b) of the Agreement is not amended under this Amendment. 
  

	3.	COMPENSATION 

 3.1 Payments from ZIOPHARM. In partial consideration
for the amendments agreed to herein by Intrexon, ZIOPHARM shall issue to Intrexon certain shares of ZIOPHARM preferred stock in accordance with the terms and conditions of the Preferred Stock Agreement. Provided that all closing conditions for
delivery of stock under the Preferred Stock Agreement that are within the reasonable control of Intrexon have been satisfied or waived, the issuance of all shares under the Preferred Stock Agreement in satisfaction of this Section 3.1 is a
condition subsequent to the effectiveness of this Amendment.  








	4.	MISCELLANEOUS 

 4.1 Full Force and Effect. This Amendment amends
the terms of the Agreement and is deemed incorporated into the Agreement. The provisions of the Agreement as amended remain in full force and effect.  

4.2 Entire Agreement. The Agreement, together with the Preferred Stock Agreement, constitute the entire agreement, both written and
oral, between the Parties with respect to the subject matter hereof, and any and all prior agreements with respect to the subject matter hereof, either written or oral, expressed or implied, are superseded hereby, merged and canceled, and are null
and void and of no effect. 
 4.3 Counterparts. This Amendment may be executed in one or more counterparts, each of which will be an
original and all of which together will constitute one instrument. 

  
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 IN WITNESS WHEREOF, Intrexon
and ZIOPHARM have executed this Amendment by their respective duly authorized representatives as of the Amendment Effective Date. 
  

									
	INTREXON CORPORATION	 	 	 	ZIOPHARM ONCOLOGY, INC.
					
	By:	 	 /s/ Randal J. Kirk
	 	 	 	By:	 	 /s/ Laurence J. N. Cooper, M.D., Ph.D.

	Name: Randal J. Kirk	 	 	 	Name: Laurence J. N. Cooper, M.D., Ph.D.
	Title: Chief Executive Officer	 	 	 	Title: Chief Executive Officer

 Signature Page to Amendment to Exclusive Channel
Collaboration Agreement