**Exhibit 12.1**

 

**Certification by the Chief Executive Officer**

**Of 3SBio Inc.**

**Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002**

 

I, Jing Lou, certify that:

 
| 1. | I have reviewed this annual report on Form 20-F   of 3SBio Inc. for the fiscal year ended December 31, 2010; |
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| 2. | Based on my knowledge, this report does not   contain any untrue statement of a material fact or omit to state a material   fact necessary to make the statements made, in light of the circumstances   under which such statements were made, not misleading with respect to the   period covered by this report; |
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| 3. | Based on my knowledge, the consolidated financial   statements, and other financial information included in this report, fairly   present in all material respects the financial condition, results of   operations and cash flows of the company as of, and for, the periods   presented in this report; |
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| 4.     | The company’s other certifying officer and I are   responsible for establishing and maintaining disclosure controls and   procedures (as defined in Exchange Act Rules 13a-15(e) and   15d-15(e)) and internal control over financial reporting (as defined in   Exchange Act Rules 13a-15(f) and 15d-15(f)) for the company and   have: |
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|   |                                                                                                                                                                                                                                                                                                                                                              |
|   | (a)                                                                                                                                                                                                                                                                                                                                                               | Designed such disclosure controls and procedures,   or caused such disclosure controls and procedures to be designed under our   supervision, to ensure that material information relating to the company,   including its consolidated subsidiaries, is made known to us by others within   those entities, particularly during the period in which this report is being   prepared; |
|   | (b)                                                                                                                                                                                                                                                                                                                                                          | Designed such internal control over financial   reporting, or caused such internal control over financial reporting to be   designed under our supervision, to provide reasonable assurance regarding the   reliability of financial reporting and the preparation of the consolidated   financial statements for external purposes in accordance with generally   accepted accounting principles; |
|   | (c)                                                                                                                                                                                                                                                                                                                                                               | Evaluated the effectiveness of the company’s   disclosure controls and procedures and presented in this report our   conclusions about the effectiveness of the disclosure controls and   procedures, as of the end of the period covered by this report based on such   evaluation; and |
|   | (d)                                                                                                                                                                                                                                                                                                                                                               | Disclosed in this report any change in the   company’s internal control over financial reporting that occurred during the   period covered by this report that has materially affected, or is reasonably   likely to materially affect, the company’s internal control over financial   reporting; and |

 
| 5.     | The company’s other certifying officer and I have   disclosed, based on our most recent evaluation of internal control over   financial reporting, to the company’s auditors and the audit committee of the   company’s board of directors (or persons performing the equivalent function): |
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|   |                                                                                                                                                                                                                                                                                                       |
|   | (a)                                                                                                                                                                                                                                                                                                        | All significant deficiencies and material   weaknesses in the design or operation of internal control over financial   reporting which are reasonably likely to adversely affect the company’s   ability to record, process, summarize and report financial information; and |
|   | (b)                                                                                                                                                                                                                                                                                                        | Any fraud, whether or not material, that involves   management or other employees who have a significant role in the company’s   internal control over financial reporting. |

 

Date: June 3, 2011

 
|       |                        |       |
|------------|-----------------------------|------------|
| By:        | /s/ DR. JING LOU            |       |
| **Name:**  | **Dr. Jing Lou**       | ** ** |
| **Title:** | **Chief Executive Officer** | ** ** |

 

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