[Federal Register Volume 75, Number 105 (Wednesday, June 2, 2010)]
[Notices]
[Page 30779]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2010-13200]


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DEPARTMENT OF COMMERCE

National Institute of Standards and Technology


Notice of Jointly Owned Invention Available for Licensing

AGENCY: National Institute of Standards and Technology, Commerce.

ACTION: Notice of jointly owned invention available for licensing.

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SUMMARY: The invention listed below is jointly owned by the U.S. 
Government, as represented by the Department of Commerce, and by 
Applied Research Associates, Inc. The Department of Commerce's interest 
in the invention is available for licensing in accordance with 35 
U.S.C. 207 and 37 CFR part 404 to achieve expeditious commercialization 
of results of federally funded research and development.

FOR FURTHER INFORMATION CONTACT: Technical and licensing information on 
this invention may be obtained by writing to: National Institute of 
Standards and Technology, Office of Technology Partnerships, Building 
222, Room A242, Gaithersburg, MD 20899. Information is also available 
via telephone: 301-975-2649, fax 301-975-3482, or e-mail: 
<a href="/cdn-cgi/l/email-protection#5c323d28343d303539722e353329241c32352f28723b332a"><span class="__cf_email__" data-cfemail="4a242b3e222b26232f643823253f320a2423393e642d253c">[email protected]</span></a>. Any request for information should include the 
NIST Docket number or Patent number and title for the invention as 
indicated below.
    The invention available for licensing is:

[NIST DOCKET NUMBER: 10-004]

    Title: Gradient Elution Moving Boundary Electrophoresis for the 
Analysis of Complex Samples and Detection of Toxins.
    Abstract: Methods of detecting the presence of toxins in a sample 
using electrophoretic separations and of performing electrophoretic 
separation of complex samples are provided. The method of detecting the 
presence of toxins includes reacting a sample and a substrate with a 
signaling enzyme which converts the substrate to the product in a 
reaction medium, introducing a run buffer into a separation channel 
having an inlet end, selectively introducing at least one of the 
substrate and the product of the reaction medium into the inlet end of 
the separation channel, electrophoretically separating the substrate 
and the product, and determining the rate of conversion of the 
substrate to the product, wherein a change in the rate of conversion is 
indicative of the presence of toxins. The method of performing 
electrophoretic separations of complex samples having charged 
particulates and oppositely charged analytes comprises introducing a 
run buffer into a separation channel having an inlet end, selectively 
introducing the oppositely charged analytes in the complex sample into 
the separation channel, and electrophoretically separating the charged 
particulates and the oppositely charged analytes. Additionally, a 
device for varying with respect to time the bulk flow of a fluid in a 
separation channel of an electrophoretic device having a buffer 
reservoir in fluid contact with the separation channel is provided. The 
device includes a pressure sensor in fluid contact with a buffer 
reservoir, a high pressure reservoir in selective fluidic communication 
with the buffer reservoir, a low pressure reservoir in selective 
fluidic communication with the buffer reservoir and in fluidic 
communication with the high pressure reservoir, and a pumping device 
for pumping a gas from the low pressure reservoir to the high pressure 
reservoir.

    Dated: May 25, 2010.
Katharine B. Gebbie,
Director, Physics Laboratory.
[FR Doc. 2010-13200 Filed 6-1-10; 8:45 am]
BILLING CODE 3510-13-P


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