EX-4.3



 Exhibit 4.3 

PFIZER INC. 
 and 

THE BANK OF NEW YORK MELLON, 

Trustee 
 SIXTH SUPPLEMENTAL
INDENTURE 
 Dated as of June 3, 2016 

to 
 INDENTURE 

Dated as of January 30, 2001 

1.200% Notes due 2018 
 1.450%
Notes due 2019 
 1.950% Notes due 2021 

2.750% Notes due 2026 







 TABLE OF CONTENTS 
  

					
	 	  	Page	 
	ARTICLE ONE	  			
		
	DEFINITIONS	  			
		
	 Section 101. Definition of Terms
	  	 	2	  
		
	ARTICLE TWO	  			
		
	GENERAL TERMS AND CONDITIONS OF THE 2018 NOTES	  			
		
	 Section 201. Designation and Principal Amount
	  	 	2	  
	 Section 202. Maturity
	  	 	2	  
	 Section 203. Further Issues
	  	 	2	  
	 Section 204. Global Notes
	  	 	2	  
	 Section 205. Interest
	  	 	3	  
	 Section 206. Authorized Denominations
	  	 	3	  
	 Section 207. Redemption
	  	 	3	  
	 Section 208. Appointment of Agents
	  	 	3	  
		
	ARTICLE THREE	  			
		
	GENERAL TERMS AND CONDITIONS OF THE 2019 NOTES	  			
		
	 Section 301. Designation and Principal Amount
	  	 	3	  
	 Section 302. Maturity
	  	 	3	  
	 Section 303. Further Issues
	  	 	3	  
	 Section 304. Global Notes
	  	 	4	  
	 Section 305. Interest
	  	 	4	  
	 Section 306. Authorized Denominations
	  	 	4	  
	 Section 307. Redemption
	  	 	4	  
	 Section 308. Appointment of Agents
	  	 	4	  
		
	ARTICLE FOUR	  			
		
	GENERAL TERMS AND CONDITIONS OF THE 2021 NOTES	  			
		
	 Section 401. Designation and Principal Amount
	  	 	4	  
	 Section 402. Maturity
	  	 	4	  
	 Section 403. Further Issues
	  	 	5	  
	 Section 404. Global Notes
	  	 	5	  
	 Section 405. Interest
	  	 	5	  
	 Section 406. Authorized Denominations
	  	 	5	  
	 Section 407. Redemption
	  	 	5	  
	 Section 408. Appointment of Agents
	  	 	5	  


  
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	ARTICLE FIVE	  			
		
	GENERAL TERMS AND CONDITIONS OF THE 2026 NOTES	  			
		
	 Section 501. Designation and Principal Amount
	  	 	5	  
	 Section 502. Maturity
	  	 	6	  
	 Section 503. Further Issues
	  	 	6	  
	 Section 504. Global Notes
	  	 	6	  
	 Section 505. Interest
	  	 	6	  
	 Section 506. Authorized Denominations
	  	 	6	  
	 Section 507. Redemption
	  	 	6	  
	 Section 508. Appointment of Agents
	  	 	6	  
		
	ARTICLE SIX	  			
		
	OPTIONAL REDEMPTION; NO SINKING FUND	  			
		
	 Section 601. Optional Redemption by Company
	  	 	7	  
	 Section 602. No Sinking Fund
	  	 	10	  
		
	ARTICLE SEVEN	  			
		
	FORMS OF NOTES	  			
		
	 Section 701. Form of 2018 Note
	  	 	10	  
	 Section 702. Form of 2019 Note
	  	 	10	  
	 Section 703. Form of 2021 Note
	  	 	10	  
	 Section 704. Form of 2026 Note
	  	 	10	  
		
	ARTICLE EIGHT	  			
		
	ORIGINAL ISSUE AMOUNT OF NOTES	  			
		
	 Section 801. Original Issue Amount of the 2018 Notes
	  	 	10	  
	 Section 802. Original Issue Amount of the 2019 Notes
	  	 	10	  
	 Section 803. Original Issue Amount of the 2021 Notes
	  	 	11	  
	 Section 804. Original Issue Amount of the 2026 Notes
	  	 	11	  
		
	ARTICLE NINE	  			
		
	MISCELLANEOUS	  			
		
	 Section 901. Ratification of Indenture
	  	 	11	  
	 Section 902. Trustee Not Responsible for Recitals
	  	 	11	  
	 Section 903. Governing Law
	  	 	11	  
	 Section 904. Separability
	  	 	11	  
	 Section 905. Counterparts
	  	 	11	  
	 Section 906. Trust Indenture Act
	  	 	12	  


  
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 Exhibits 
 Exhibit
A         Form of 2018 Note 
 Exhibit B         Form of 2019 Note 

Exhibit C         Form of 2021 Note 

Exhibit D        Form of 2026 Note 

  
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 SIXTH SUPPLEMENTAL INDENTURE, dated as of June 3, 2016 (the “Sixth Supplemental
Indenture”), between Pfizer Inc., a corporation duly organized and existing under the laws of the State of Delaware, having its principal office at 235 East 42nd Street, New York, New York 10017 (the “Company”), and The Bank of New
York Mellon (formerly The Bank of New York, a New York banking corporation (successor to JPMorgan Chase Bank, N.A. (formerly JPMorgan Chase Bank, formerly The Chase Manhattan Bank (successor to The Chase Manhattan Bank (National Association)))), as
trustee (the “Trustee”). 
 WHEREAS, the Company executed and delivered the indenture, dated as of January 30, 2001, to the
Trustee (the “Indenture”), to provide for the issuance of the Company’s notes, bonds, debentures or any other evidences of indebtedness (the “Securities”), in one or more fully registered series; 

WHEREAS, pursuant to Section 901 of the Indenture, the Company desires to provide for the issuance of (i) a new series of its
Securities to be known as its 1.200% Notes due 2018 (the “2018 Notes”), (ii) a new series of its Securities to be known as its 1.450% Notes due 2019 (the “2019 Notes”), (iii) a new series of its Securities to be known
as its 1.950% Notes due 2021 (the “2021 Notes”) and (iv) a new series of its Securities to be known as its 2.750% Notes due 2026 (the “2026 Notes”) (the 2026 Notes, together with the 2018 Notes, the 2019 Notes and the 2021
Notes, the “Notes”), and to establish the forms of the Notes thereof, as provided in Section 202 of the Indenture, and to set forth the terms thereof, as provided in Section 301 of the Indenture; 

WHEREAS, the Board of Directors of the Company, pursuant to resolutions duly adopted, has duly authorized the issuance of the Company’s
debt securities and the Securities Issuance Committee of the Company, pursuant to a resolution duly adopted on May 31, 2016, has duly authorized the issuance of $1,250,000,000 aggregate principal amount of 2018 Notes, $850,000,000 aggregate
principal amount of 2019 Notes, $1,150,000,000 aggregate principal amount of 2021 Notes and $1,250,000,000 aggregate principal amount of 2026 Notes, and has authorized the proper officers of the Company to execute any and all appropriate documents
necessary or appropriate to effect such issuance; 
 WHEREAS, the Company has requested that the Trustee execute and deliver this Sixth
Supplemental Indenture; and 
 WHEREAS, all things necessary to make this Sixth Supplemental Indenture a valid agreement of the Company, in
accordance with its terms, and to make the Notes, when executed by the Company and authenticated and delivered by the Trustee, the valid obligations of the Company, have been done; 

NOW THEREFORE, in consideration of the premises and the purchase and acceptance of the Notes by the Holders thereof, and for the purpose of
setting forth, as provided in the Indenture, the forms and terms of the Notes, it is mutually covenanted and agreed, for the equal and proportionate benefit of all Holders of the Notes, as follows: 







 ARTICLE ONE 

DEFINITIONS 

Section 101. Definition of Terms. Unless the context otherwise requires: 

(a) each term defined in the Indenture has the same meaning when used in this Sixth Supplemental Indenture; 

(b) each term defined anywhere in this Sixth Supplemental Indenture has the same meaning throughout; 

(c) the singular includes the plural and vice versa; and 

(d) headings are for convenience of reference only and do not affect interpretation. 

ARTICLE TWO 
 GENERAL
TERMS AND CONDITIONS OF THE 2018 NOTES 
 Section 201. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “1.200% Notes due 2018”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2018 Notes to be issued on the date hereof is set
forth in Article Eight herein. 
 Section 202. Maturity. The Stated Maturity of principal of the 2018 Notes is June 1,
2018. 
 Section 203. Further Issues. The Company may from time to time, without the consent of the Holders of the 2018 Notes,
issue additional 2018 Notes. Any such additional 2018 Notes will have the same ranking, interest rate, maturity date and other terms as the 2018 Notes herein provided for. Any such additional 2018 Notes, together with the 2018 Notes herein provided
for, will constitute a single series of Securities under the Indenture. No additional 2018 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2018 Notes. The Company will not issue any additional 2018 Notes
intended to form a single series with the 2018 Notes herein provided for unless such additional 2018 Notes will be fungible with the 2018 Notes herein provided for, for U.S. federal income tax purposes. 

Section 204. Global Notes. Upon their original issuance, the 2018 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of The Depository Trust Company (“DTC”). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede &
Co. 

  
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 Section 205. Interest. The 2018 Notes will bear interest (computed on the basis of a
360-day year consisting of twelve 30-day months) from June 3, 2016 at the rate of 1.200% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued
from June 3, 2016, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are June 1 and December 1, beginning on
December 1, 2016; and the Regular Record Date for the interest payable on any Interest Payment Date is the close of business on the May 17 or November 16 (whether or not a Business Day), as the case may be, immediately preceding the
relevant Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will
accrue on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. 

Section 206. Authorized Denominations. The 2018 Notes shall be issuable in denominations of $2,000 and integral multiples of
$1,000 in excess thereof. 
 Section 207. Redemption. The 2018 Notes are subject to redemption at the option of the Company as
described in Article Six hereof. 
 Section 208. Appointment of Agents. The Trustee will initially be the Security Registrar and
Paying Agent for the 2018 Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

ARTICLE THREE 
 GENERAL
TERMS AND CONDITIONS OF THE 2019 NOTES 
 Section 301. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “1.450% Notes due 2019”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2019 Notes to be issued on the date hereof is set
forth in Article Eight herein. 
 Section 302. Maturity. The Stated Maturity of principal of the 2019 Notes is June 3,
2019. 
 Section 303. Further Issues. The Company may from time to time, without the consent of the Holders of the 2019 Notes,
issue additional 2019 Notes. Any such additional 2019 Notes will have the same ranking, interest rate, maturity date and other terms as the 2019 Notes herein provided for. Any such additional 2019 Notes, together with the 2019 Notes herein provided
for, will constitute a single series of Securities under the Indenture. No additional 2019 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2019 Notes. The Company will not issue any additional 2019 Notes
intended to form a single series with the 2019 Notes herein provided for unless such additional 2019 Notes will be fungible with the 2019 Notes herein provided for, for U.S. federal income tax purposes. 

  
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 Section 304. Global Notes. Upon their original issuance, the 2019 Notes will be
represented by one or more Global Securities registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede & Co. 
 Section 305. Interest. The 2019 Notes will bear interest (computed on the basis of a 360-day year
consisting of twelve 30-day months) from June 3, 2016 at the rate of 1.450% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from
June 3, 2016, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are June 3 and December 3, beginning on
December 3, 2016; and the Regular Record Date for the interest payable on any Interest Payment Date is the close of business on the May 19 or November 18 (whether or not a Business Day), as the case may be, immediately preceding the
relevant Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will
accrue on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. 

Section 306. Authorized Denominations. The 2019 Notes shall be issuable in denominations of $2,000 and integral multiples of
$1,000 in excess thereof. 
 Section 307. Redemption. The 2019 Notes are subject to redemption at the option of the Company as
described in Article Six hereof. 
 Section 308. Appointment of Agents. The Trustee will initially be the Security Registrar and
Paying Agent for the 2019 Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

ARTICLE FOUR 
 GENERAL
TERMS AND CONDITIONS OF THE 2021 NOTES 
 Section 401. Designation and Principal Amount. There is hereby authorized and
established a series of Securities under the Indenture, designated as the “1.950% Notes due 2021”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2021 Notes to be issued on the date hereof is set
forth in Article Eight herein. 
 Section 402. Maturity. The Stated Maturity of principal of the 2021 Notes is June 3,
2021. 

  
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 Section 403. Further Issues. The Company may from time to time, without the consent
of the Holders of the 2021 Notes, issue additional 2021 Notes. Any such additional 2021 Notes will have the same ranking, interest rate, maturity date and other terms as the 2021 Notes herein provided for. Any such additional 2021 Notes, together
with the 2021 Notes herein provided for, will constitute a single series of Securities under the Indenture. No additional 2021 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2021 Notes. The Company will
not issue any additional 2021 Notes intended to form a single series with the 2021 Notes herein provided for unless such additional 2021 Notes will be fungible with the 2021 Notes herein provided for, for U.S. federal income tax purposes. 

Section 404. Global Notes. Upon their original issuance, the 2021 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede & Co. 

Section 405. Interest. The 2021 Notes will bear interest (computed on the basis of a 360-day year consisting of twelve 30-day
months) from June 3, 2016 at the rate of 1.950% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from June 3, 2016, or from the most
recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are June 3 and December 3, beginning on December 3, 2016; and the Regular Record
Date for the interest payable on any Interest Payment Date is the close of business on the May 19 or November 18 (whether or not a Business Day), as the case may be, immediately preceding the relevant Interest Payment Date. If any Interest
Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that payment for the period from and
after that Interest Payment Date to the date of payment on the next succeeding Business Day. 
 Section 406. Authorized
Denominations. The 2021 Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Section 407. Redemption. The 2021 Notes are subject to redemption at the option of the Company as described in Article Six hereof.

 Section 408. Appointment of Agents. The Trustee will initially be the Security Registrar and Paying Agent for the 2021 Notes
and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 
 ARTICLE FIVE 

GENERAL TERMS AND CONDITIONS OF THE 2026 NOTES 

Section 501. Designation and Principal Amount. There is hereby authorized and established a series of Securities under the
Indenture, designated as the “2.750% Notes due 2026”, which is not limited in aggregate principal amount. The aggregate principal amount of the 2026 Notes to be issued on the date hereof is set forth in Article Eight herein. 

  
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 Section 502. Maturity. The Stated Maturity of principal of the 2026 Notes is
June 3, 2026. 
 Section 503. Further Issues. The Company may from time to time, without the consent of the Holders of the
2026 Notes, issue additional 2026 Notes. Any such additional 2026 Notes will have the same ranking, interest rate, maturity date and other terms as the 2026 Notes herein provided for. Any such additional 2026 Notes, together with the 2026 Notes
herein provided for, will constitute a single series of Securities under the Indenture. No additional 2026 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2026 Notes. The Company will not issue any
additional 2026 Notes intended to form a single series with the 2026 Notes herein provided for unless such additional 2026 Notes will be fungible with the 2026 Notes herein provided for, for U.S. federal income tax purposes. 

Section 504. Global Notes. Upon their original issuance, the 2026 Notes will be represented by one or more Global Securities
registered in the name of Cede & Co., the nominee of DTC. The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of Cede & Co. 

Section 505. Interest. The 2026 Notes will bear interest (computed on the basis of a 360-day year consisting of twelve 30-day
months) from June 3, 2016 at the rate of 2.750% per annum, payable semiannually in arrears; interest payable on each Interest Payment Date (as defined in the Indenture) will include interest accrued from June 3, 2016, or from the most
recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are June 3 and December 3, beginning on December 3, 2016; and the Regular Record
Date for the interest payable on any Interest Payment Date is the close of business on the May 19 or November 18 (whether or not a Business Day), as the case may be, immediately preceding the relevant Interest Payment Date. If any Interest
Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that payment for the period from and
after that Interest Payment Date to the date of payment on the next succeeding Business Day. 
 Section 506. Authorized
Denominations. The 2026 Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Section 507. Redemption. The 2026 Notes are subject to redemption at the option of the Company as described in Article Six hereof.

 Section 508. Appointment of Agents. The Trustee will initially be the Security Registrar and Paying Agent for the 2026 Notes
and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. 

  
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 ARTICLE SIX 

OPTIONAL REDEMPTION; NO SINKING FUND 

Section 601. Optional Redemption by Company. 

(a) At the Company’s option, the 2018 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2018
Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2018 Redemption Price”) equal to the greater of the following amounts: 

(i) 100% of the principal amount of the 2018 Notes being redeemed on the relevant 2018 Redemption Date, and 

(ii) the sum of the present values of the remaining scheduled payments of principal and interest on the 2018 Notes being
redeemed on the applicable 2018 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2018 Redemption Date) discounted to such 2018 Redemption Date on a semi-annual basis at the Treasury Rate as
determined by the Independent Investment Banker, plus 5 basis points; 
 plus, in each of the cases of (i) and (ii) above, accrued and
unpaid interest on the 2018 Notes being redeemed to, but excluding, such 2018 Redemption Date. 
 (b) At the Company’s option, the 2019
Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2019 Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2019
Redemption Price”) equal to the greater of the following amounts: 
 (i) 100% of the principal amount of the 2019 Notes
being redeemed on the relevant 2019 Redemption Date, and 
 (ii) the sum of the present values of the remaining scheduled
payments of principal and interest on the 2019 Notes being redeemed on the applicable 2019 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2019 Redemption Date) discounted to such 2019
Redemption Date on a semi-annual basis at the Treasury Rate, as determined by the Independent Investment Banker, plus 7 basis points; 
 plus, in
each of the cases of (i) and (ii) above, accrued and unpaid interest on the 2019 Notes being redeemed to, but excluding, such 2019 Redemption Date. 

(c) At the Company’s option, the 2021 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2021
Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year consisting of twelve 30-day months (the “2021 Redemption Price”) equal to the greater of the following amounts: 

(i) 100% of the principal amount of the 2021 Notes being redeemed on the relevant 2021 Redemption Date, and 

  
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 (ii) the sum of the present values of the remaining scheduled payments of
principal and interest on the 2021 Notes being redeemed on the applicable 2021 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2021 Redemption Date) discounted to such 2021 Redemption Date on
a semi-annual basis at the Treasury Rate, as determined by the Independent Investment Banker, plus 10 basis points; 
 plus, in each of the cases of
(i) and (ii) above, accrued and unpaid interest on the 2021 Notes being redeemed to, but excluding, such 2021 Redemption Date. 

(d) At the Company’s option, the 2026 Notes may be redeemed, in whole or in part, at any time and from time to time (each a “2026
Redemption Date”; any 2018 Redemption Date, 2019 Redemption Date, 2021 Redemption Date or 2026 Redemption Date is herein referred to as a “Redemption Date”) at a redemption price to be calculated on the basis of a 360-day year
consisting of twelve 30-day months (the “2026 Redemption Price”; any 2018 Redemption Price, 2019 Redemption Price, 2021 Redemption Price or 2026 Redemption Price is herein referred to as a “Redemption Price”) equal to the greater
of the following amounts: 
 (i) 100% of the principal amount of the 2026 Notes being redeemed on the relevant 2026
Redemption Date, and 
 (ii) the sum of the present values of the remaining scheduled payments of principal and interest on
the 2026 Notes being redeemed on the applicable 2026 Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such 2026 Redemption Date) discounted to such 2026 Redemption Date on a semi-annual basis at
the Treasury Rate, as determined by the Independent Investment Banker, plus 15 basis points; 
 plus, in each of the cases of (i) and
(ii) above, accrued and unpaid interest on the 2026 Notes being redeemed to, but excluding, such 2026 Redemption Date. 
 (e) Notice of
any redemption of the Notes of any series shall be given in the manner and otherwise in accordance with the provisions of Section 1104 of the Indenture; provided, however, that notice of redemption shall be given by first-class
mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the
applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of redemption as provided in the Indenture and funds for the redemption of the Notes called for redemption have
been made available on the Redemption Date referred to in that notice, such Notes will cease to bear interest on such Redemption Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest).
Any interest accrued to such Redemption Date will be paid as specified in such notice. 

  
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 (f) The following defined terms used in this Article Six shall, unless the context otherwise
requires, have the meanings specified below. 
 “Comparable Treasury Issue” means the United States Treasury security selected by
the Independent Investment Banker as having a maturity comparable to the remaining term of the applicable Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new
issues of corporate debt securities of comparable maturity to the remaining term of such Notes. 
 “Comparable Treasury Price”
means (A) the average of the Reference Treasury Dealer Quotations for the applicable Redemption Date and the applicable Notes to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if
the Independent Investment Banker obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference
Treasury Dealer Quotation. 
 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company
to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Barclays Capital Inc.,
Goldman, Sachs & Co., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Notes to be
redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Notes (expressed in each case as a percentage of its principal amount) quoted in writing to the
Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

(g) In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Notes to be 

  
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redeemed, the Company shall deliver an Officers’ Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be
calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may conclusively presume the correctness of, and shall be fully protected in relying upon, the applicable Redemption Price as so calculated,
or the manner in which such Redemption Price shall be calculated, as relevant, and set forth in such Officers’ Certificate. 

Section 602. No Sinking Fund. None of the 2018 Notes, the 2019 Notes, the 2021 Notes or the 2026 Notes are entitled to the benefit
of any sinking fund. 
 ARTICLE SEVEN 

FORMS OF NOTES 

Section 701. Form of 2018 Note. The 2018 Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to
be substantially in the forms set forth in Exhibit A hereto. 
 Section 702. Form of 2019 Note. The 2019 Notes and the
Trustee’s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit B hereto. 

Section 703. Form of 2021 Note. The 2021 Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to
be substantially in the forms set forth in Exhibit C hereto. 
 Section 704. Form of 2026 Note. The 2026 Notes and the
Trustee’s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit D hereto. 

ARTICLE EIGHT 
 ORIGINAL
ISSUE AMOUNT OF NOTES 
 Section 801. Original Issue Amount of the 2018 Notes. 2018 Notes in the aggregate principal amount
of $1,250,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and deliver said 2018 Notes
as provided in said Company Order. 
 Section 802. Original Issue Amount of the 2019 Notes. 2019 Notes in the aggregate
principal amount of $850,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and deliver
said 2019 Notes as provided in said Company Order. 

  
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 Section 803. Original Issue Amount of the 2021 Notes. 2021 Notes in the aggregate
principal amount of $1,150,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and deliver
said 2021 Notes as provided in said Company Order. 
 Section 804. Original Issue Amount of the 2026 Notes. 2026 Notes in the
aggregate principal amount of $1,250,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate
and deliver said 2026 Notes as provided in said Company Order. 
 ARTICLE NINE 

MISCELLANEOUS 

Section 901. Ratification of Indenture. The Indenture, as supplemented by this Sixth Supplemental Indenture, is in all respects
ratified and confirmed, and this Sixth Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided. 

Section 902. Trustee Not Responsible for Recitals. The recitals and statements herein contained are made by the Company and not by
the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Sixth Supplemental Indenture. 

Section 903. Governing Law. This Sixth Supplemental Indenture and each Note shall be governed by and construed in accordance with
the laws of the State of New York. 
 Section 904. Separability. In case any one or more of the provisions contained in this
Sixth Supplemental Indenture or in the Notes shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Sixth Supplemental
Indenture or of the Notes, but this Sixth Supplemental Indenture and the Notes shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein. 

Section 905. Counterparts. This Sixth Supplemental Indenture may be executed in any number of counterparts each of which shall be
an original; but such counterparts shall together constitute but one and the same instrument. The exchange of copies of this Sixth Supplemental Indenture and of signature pages by facsimile or electronic format (i.e., “pdf” or
“tif”) transmission shall constitute effective execution and delivery of this Sixth Supplemental Indenture as to the parties hereto and may be used in lieu of the original Sixth Supplemental Indenture for all purposes. Signatures of the
parties hereto transmitted by facsimile or electronic format (i.e., “pdf” or “tif”) shall be deemed to be their original signatures for all purposes. 

  
 -11- 








 Section 906. Trust Indenture Act. This Sixth Supplemental Indenture is subject to the
provisions of the Trust Indenture Act that are required to be part of the Indenture and shall, to the extent applicable, be governed by such provisions. If any provision in this Sixth Supplemental Indenture limits, qualifies or conflicts with
another provision of hereof which is required to be included herein by any provisions of the Trust Indenture Act, such required provision shall control. 

  
 -12- 








 IN WITNESS WHEREOF, the parties hereto have caused this Sixth Supplemental Indenture to be duly executed, all as
of the day and year first above written. 
  

			
	PFIZER INC.
		
	By:	 	/s/ Brian Byala
		 	Name: Brian Byala
		 	Title: Senior Vice President and Treasurer
	
	 THE BANK OF NEW YORK MELLON, as

    Trustee

		
	By:	 	/s/ Francine Kincaid
		 	Name: Francine Kincaid
		 	Title: Vice President



  
 [Signature Page to
Sixth Supplemental Indenture] 








 EXHIBIT A 

FORM OF 2018 NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME
OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A
NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 Unless this certificate is presented by an
authorized representative of The Depository Trust Company, a New York corporation (“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of
Cede & Co. or in such other name as is requested by an authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 

PFIZER INC. 
 1.200% NOTES DUE
2018 
 CUSIP No. 717081 DW0 
 No. [•]

 Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term
includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [•] DOLLARS ($[•]) on June 1, 2018, and to pay
interest thereon from June 3, 2016 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears, on June 1 and December 1 in each year, beginning December 1, 2016 at
the rate of 1.200% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the
Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the May 17 or November 16 (whether or not a Business Day), as
the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in
whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of
Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be
listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal
of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of
payment is legal tender for payment of public and private debts. 
 All payments of principal, premium, if any, and interest in respect of
this Security will be made by the Company in immediately available funds. 

  
 A-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 A-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
				
	Dated:	 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	 
		 	Name:
		 	Title:
		
	 Dated:
	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.
  

The Bank of New York Mellon, as Trustee

				
		 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:


  
 A-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the sixth supplemental indenture dated as of June 3, 2016 (herein called the “Indenture”, which then shall have the meaning assigned
to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,250,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 5 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 A-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Barclays
Capital Inc., Goldman, Sachs & Co., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 A-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 A-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 
  

 
 (Please insert
social security or other identifying number of assignee) 
  
  

 
  
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

			
	Date:	 	 

  

	
	   

	


  

	
	   

	(Signature Guarantee)


  
 A-7 








 EXHIBIT B 

FORM OF 2019 NOTE 

THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME
OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A
NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 Unless this certificate is presented by an
authorized representative of The Depository Trust Company, a New York corporation (“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of
Cede & Co. or in such other name as is requested by an authorized representative of DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR
OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the registered owner hereof, Cede & Co., has an interest herein. 

PFIZER INC. 
 1.450% NOTES DUE
2019 
 CUSIP No. 717081 DU4 
 No. [•]

 Pfizer Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term
includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or registered assigns, the principal sum of [•] DOLLARS ($[•]) on June 3, 2019, and to pay
interest thereon from June 3, 2016 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in arrears, on June 3 and December 3 in each year, beginning December 3, 2016 at
the rate of 1.450% per annum until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the
Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the May 19 or November 18 (whether or not a Business Day), as
the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in
whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of
Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be
listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal
of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of
payment is legal tender for payment of public and private debts. 
 All payments of principal, premium, if any, and interest in respect of
this Security will be made by the Company in immediately available funds. 

  
 B-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 B-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
				
	Dated:	 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	 
		 	Name:
		 	Title:
		
	 Dated:
	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated therein referred to in the within-mentioned Indenture.
  

The Bank of New York Mellon, as Trustee

				
		 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:


  
 B-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the sixth supplemental indenture dated as of June 3, 2016 (herein called the “Indenture”, which then shall have the meaning assigned
to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$850,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 7 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 B-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Barclays
Capital Inc., Goldman, Sachs & Co., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 B-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 B-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 
  

 
 (Please insert
social security or other identifying number of assignee) 
  
  

 
  
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

			
	Date:	 	 

  

	
	   

	


  

	
	   

	(Signature Guarantee)


  
 B-7 








 EXHIBIT C 

FORM OF 2021 NOTE 
 THIS SECURITY
IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF
THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

Unless this certificate is presented by an authorized representative of The Depository Trust Company, a New York corporation
(“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as is requested by an authorized representative of
DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the
registered owner hereof, Cede & Co., has an interest herein. 
 PFIZER INC. 

1.950% NOTES DUE 2021 
 CUSIP
No. 717081 DX8 
 No. [•] 
 Pfizer
Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to
Cede & Co. or registered assigns, the principal sum of [•] DOLLARS ($[•]) on June 3, 2021, and to pay interest thereon from June 3, 2016 or from the most recent Interest Payment Date to which interest has been paid or
duly provided for, semi-annually in arrears, on June 3 and December 3 in each year, beginning December 3, 2016 at the rate of 1.950% per annum until the principal hereof is paid or made available for payment. The interest so
payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on
the Regular Record Date for such interest, which shall be the May 19 or November 18 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly
provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 C-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 C-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
				
	Dated:	 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	  

		 	Name:
		 	Title:
	Dated:	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated
 therein referred to in the within-mentioned Indenture.

 
 The Bank of New York Mellon, as Trustee

				
		 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:


  
 C-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the sixth supplemental indenture dated as of June 3, 2016 (herein called the “Indenture”, which then shall have the meaning assigned
to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,150,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 10 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 C-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Barclays
Capital Inc., Goldman, Sachs & Co., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series, with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
 C-5 








 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
 C-6 








 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 
  

 
 (Please insert
social security or other identifying number of assignee) 
  
  

 
  
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  

Attorney to transfer said Securities on the books of the Company with full power of substitution in the premises. 

 

			
	Date:	 	 

  

	
	   

	


  

	
	   

	(Signature Guarantee)


  
 C-7 








 EXHIBIT D 

FORM OF 2026 NOTE 
 THIS SECURITY
IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF
THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

Unless this certificate is presented by an authorized representative of The Depository Trust Company, a New York corporation
(“DTC”), to the Company or its agent for registration of transfer, exchange, or payment, and any certificate issued is registered in the name of Cede & Co. or in such other name as is requested by an authorized representative of
DTC (and any payment is made to Cede & Co. or to such other entity as is requested by an authorized representative of DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL inasmuch as the
registered owner hereof, Cede & Co., has an interest herein. 
 PFIZER INC. 

2.750% NOTES DUE 2026 
 CUSIP
No. 717081 DV2 
 No. [•] 
 Pfizer
Inc., a corporation duly organized and existing under the laws of Delaware (herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to
Cede & Co. or registered assigns, the principal sum of [•] DOLLARS ($[•]) on June 3, 2026, and to pay interest thereon from June 3, 2016 or from the most recent Interest Payment Date to which interest has been paid or
duly provided for, semi-annually in arrears, on June 3 and December 3 in each year, beginning December 3, 2016 at the rate of 2.750% per annum until the principal hereof is paid or made available for payment. The interest so
payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on
the Regular Record Date for such interest, which shall be the May 19 or November 18 (whether or not a Business Day), as the case may be, immediately preceding such Interest Payment Date. Any such interest not so punctually paid or duly
provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special
Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other
lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Security will be made at the office or agency of the Company maintained
for that purpose in the Borough of Manhattan, State of New York, in such coin or currency of the United States as at the time of payment is legal tender for payment of public and private debts. 

All payments of principal, premium, if any, and interest in respect of this Security will be made by the Company in immediately available
funds. 

  
 D-1 








 Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose. 

  
 D-2 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 
  

							
		 		 	PFIZER INC.
				
	Dated:	 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:

  

			
	Attest:	 	  

		 	Name:
		 	Title:
		
	Dated:	 	

  

							
		 		 	 CERTIFICATE OF AUTHENTICATION
 This
is one of the Securities of the series designated
 therein referred to in the within-mentioned Indenture.

 
 The Bank of New York Mellon, as Trustee

				
		 		 	By:	 	 
		 		 		 	Name:
		 		 		 	Title:


  
 D-3 








 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of January 30, 2001 as supplemented by the sixth supplemental indenture dated as of June 3, 2016 (herein called the “Indenture”, which then shall have the meaning assigned
to it in such instrument) between the Company and The Bank of New York Mellon, formerly known as The Bank of New York, as successor to JPMorgan Chase Bank, formerly known as The Chase Manhattan Bank, as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof initially limited in aggregate principal amount to
$1,250,000,000. 
 At the Company’s option, the Securities of this series may be redeemed in whole or in part at any time and from time
to time (each, a “Redemption Date”). The redemption price (the “Redemption Price”) of the Securities will be equal to the greater of the following amounts: 

(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and 

(b) the sum of the present value of the remaining scheduled payments of principal and interest on the Securities being redeemed on such
Redemption Date (not including the amount, if any, of accrued and unpaid interest to, but excluding, such Redemption Date) discounted to such Redemption Date on a semi-annual basis at the Treasury Rate (as defined below), as determined by the
Independent Investment Banker (as defined below), plus 15 basis points; 
 plus, in each case, accrued and unpaid interest on
the Securities being redeemed to, but excluding, such Redemption Date. 
 The Redemption Price will be calculated on the basis of a 360-day
year consisting of twelve 30-day months. Once notice of redemption is mailed by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price. 

Notice of any redemption of the Securities shall be given in the manner and otherwise in accordance with the provisions of Section 1104
of the Indenture; provided, however, that notice of redemption shall be given by first-class mail, postage prepaid, mailed not less than 10 nor more than 60 days prior to the Redemption Date, to each Holder of Securities to be
redeemed, at his address appearing in the Security Register, and that any such notice in lieu of stating the applicable Redemption Price, shall state the manner in which such Redemption Price shall be calculated. If the Company has given notice of
redemption as provided in the Indenture and funds for the redemption of the Securities called for redemption have been made available on the Redemption Date referred to in that notice, such Securities will cease to bear interest on such Redemption
Date (unless the Company defaults in the payment of the applicable Redemption Price and accrued and unpaid interest). Any interest accrued to such Redemption Date will be paid as specified in such notice. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Independent Investment Banker as having a
maturity comparable to the remaining term of the applicable Securities to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of
comparable maturity to the remaining term of such Securities. 
 “Comparable Treasury Price” means (A) the average of the
Reference Treasury Dealer Quotations for the applicable Redemption Date and applicable Securities to be redeemed, after excluding the highest and lowest of such Reference Treasury Dealer Quotations, or (B) if the Independent Investment Banker
obtains fewer than four such Reference Treasury Dealer Quotations, the average of such Reference Treasury Dealer Quotations, or (C) if only one Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

  
 D-4 








 “Independent Investment Banker” means one of the Reference Treasury Dealers appointed
by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealer” means each of Barclays
Capital Inc., Goldman, Sachs & Co., J.P. Morgan Securities LLC and Morgan Stanley & Co. LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any Redemption Date and Securities
to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for such Securities (expressed in each case as a percentage of its principal amount) quoted in writing to
the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such Redemption Date. 

“Treasury Rate” means the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury
Issue, assuming a price for such Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for the applicable Redemption Date. 

In connection with any such redemption, each Reference Treasury Dealer shall deliver the Comparable Treasury Price to the Company and the
Independent Investment Banker in writing two Business Days prior to the Redemption Date. At or prior to the time of giving of any notice of redemption to the Holders of any Securities to be redeemed, the Company shall deliver an Officers’
Certificate to the Trustee setting forth the calculation of the Redemption Price or the manner in which the Redemption Price shall be calculated, as relevant, applicable to such redemption. The Trustee shall be under no duty to inquire into, may
conclusively presume the correctness of, and shall be fully protected in relying upon, the Redemption Price as so calculated or the manner in which the Redemption Price shall be calculated, as relevant, and set forth in such Officers’
Certificate. 
 The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security and certain
restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series
may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain
exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the
Trustee with the consent of the Holders of a majority in principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal
amount of the Outstanding Securities of all series with respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to
waive, with certain exceptions, such past default with respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the
Holders of all Outstanding Securities of such series, to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon
all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

  
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 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall
not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder unless such Holder shall have previously given the Trustee written notice of a continuing
Event of Default with respect to the Securities of this series, the Holders of not less than a majority in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding
a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this
Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 

No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the
Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the
Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by
a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like
tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in denominations of $2,000 and integral multiples of $1,000
in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different
authorized denomination, as requested in writing by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

No recourse for the payment of the principal of or any premium or interest on any Security, or for any claim based thereon or otherwise in
respect thereof, and no recourse under or upon any obligation, covenant or agreement of the Company in the Indenture or in any supplemental indenture, or in this Security, or because of the creation of any indebtedness represented hereby, shall be
had against any incorporator, stockholder, officer or director, as such, past, present or future, of the Company or any successor corporation, either directly or through the Company or any successor corporation, whether by virtue of any
constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly understood that all such liability was expressly waived and released as a condition of, and as consideration for, the execution
of the Indenture and is a condition of, and is consideration for, the execution of this Security. 

  
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 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s) unto 

 
  

 
 (Please insert
social security or other identifying number of assignee) 
  
  

 
  
  

 
 (Please print or typewrite name and
address including postal zip code of assignee) 
 the within Security and all rights thereunder, hereby irrevocably constituting and appointing 

 
  
  

 
 Attorney to transfer said Securities on the books of
the Company with full power of substitution in the premises. 
  

			
	Date:	 	 

  

	
	   

	


  

	
	   

	(Signature Guarantee)


  
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