Federal Register / Vol. 75, No. 99 / Monday, May 24, 2010 / Notices 28811 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Office of Biotechnology Activities; 

Recombinant DNA Research: 

Proposed Actions Under the NIH 

Guidelines for Research Involving 

Recombinant DNA Molecules (NIH 

Guidelines) 

ACTION: Notice of consideration of a 

proposed action under Section III–A–1 

of the NIH Guidelines. 

SUMMARY: The NIH Guidelines requires 

certain recombinant research to be 

reviewed by the NIH Recombinant DNA 

Advisory Committee and approved by 

the NIH Director (Section III–A–1). Such 

research involves the introduction of 

drug resistance into a microorganism if 

the introduction of that drug resistance 

trait can compromise the ability to treat 

disease caused by the microorganism in 

humans, animals or agriculture. In order 

to meet the threshold for consideration 

under Section III–A–1, the 

microorganism must be able to cause 

disease in humans, animals or 

agriculture. 

A proposal to deliberately transfer a 

chloramphenicol resistance trait into an 

attenuated strain (CO92 lcr-) of Yersinia 

pestis has been submitted to the NIH 

Office of Biotechnology Activities 

(OBA) by the Institutional Biosafety 

Committee at Lawrence Livermore 

National Laboratory (LLNL). Treatment 

guidelines recommend streptomycin as 

the first-line antibiotic for treatment of 

disease caused by wild type Y. pestis, 

and gentamicin is recommended when 

streptomycin is not available. 

Doxycycline and chloramphenicol are 

also effective and ciprofloxacin is 

recommended as prophylaxis and has 

been shown to treat disease in animal 

models. The LLNL investigators will be 

using Y. pestis CO92 lcr- strains that 

have already been made resistant to 

ciprofloxacin or doxycycline through 

exposure of these attenuated strains to 

these antibiotics. The proposed research 

involves the addition of 

chloramphenicol resistance into these 

strains, thereby creating lcr- Y. pestis 

strains that are resistant to multiple 

antibiotics used to treat disease caused 

by this organism. 

A fundamental question with respect 

to this line of proposed research is 

whether this specific strain (lcr-) has the 

ability to cause disease in humans and 

therefore should be subject to Section 

III–A–1 of the NIH Guidelines. While 

there is evidence that the strain is 

attenuated, this does not necessarily 

mean the strain is avirulent, and the 

RAC will review the evidence regarding 

the ability of this strain to cause disease. 

The recent death of a researcher at the 

University of Chicago while working 

with an attenuated strain of Yersinia 

pestis highlights that attenuated strains 

may be pathogenic in certain 

populations. If a determination is made 

that that lcr- strains do pose a potential 

public health risk, then these 

experiments will be considered at this 

meeting under Section III–A–1 of the 

NIH Guidelines. A recommendation will 

then be made as to whether this 

research should be allowed to proceed 

and, if so, under what containment 

conditions. 

The RAC will review of this proposed 

work at its June 16–17, 2010 meeting, 

which will be held at the Hilton 

Washington DC/Rockville Hotel 1750 

Rockville Pike, Rockville, MD and is 

open to the public. The public may also 

submit written comments. 

DATES: The public is encouraged to 

submit written comments on this 

proposed action. Comments may be 

submitted to the OBA in paper or 

electronic form at the OBA mailing, fax, 

and e-mail addresses shown below 

under the heading FOR FURTHER

INFORMATION CONTACT. All comments 

should be submitted by June 10, 2010. 

All written comments received in 

response to this notice will be available 

for public inspection in the NIH OBA 

office, 6705 Rockledge Drive, Suite 750, 

MSC 7985, Bethesda, MD 20892–7985, 

(Phone: 301–496–9838) weekdays 

between the hours of 8:30 a.m. and 

5 p.m. 

FOR FURTHER INFORMATION CONTACT: 

Contact OBA by e-mail at 

oba@od.nih.gov, or telephone at 301– 

496–9838, if you have questions, or 

require additional information about 

this line of research. For additional 

information about the RAC meeting at 

which this line of research will be 

discussed, please visit the NIH OBA 

Web site at: http://oba.od.nih.gov/oba/

index.html. 

SUPPLEMENTARY INFORMATION: Yersinia 

pestis is the causative organism for 

plague and it regulated by the 

Department of Health and Human 

Services (HHS) as a Select Agent 

pursuant to the Select Agent 

Regulations (42 CFR part 73). There are 

a number of attenuated strains of 

Yersinia pestis that do not contain 

certain virulence factors. The strain that 

will be used in the proposed research, 

Yersinia pestis CO92 lcr-, lacks the 

plasmid called pCD1 or the ‘‘low 

calcium response-lcr’’ plasmid since it 

confers calcium dependence for growth 

at 37° C. Loss of the pCD1 plasmid is 

accompanied by a concomitant loss of 

virulence as indicated in studies using 

several animal models. This strain is 

excluded from the HHS list of Select 

Biological Agents and Toxins http:// 

www.selectagents.gov/Select%20

Agents%20and%20Toxins%20

Exclusions.html#hhsAgents. 

Additional background information 

may be obtained by contacting NIH OBA 

via e-mail at oba@od.nih.gov or by going 

to the OBA Web site at http:// 

oba.od.nih.gov/rdna/news_

events_oba.html#RAC. 

Dated: May 17, 2010. 

Jacqueline Corrigan-Curay, 

Acting Director, Office of Biotechnology 

Activities, National Institutes of Health. 

[FR Doc. 2010–12453 Filed 5–21–10; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

Statement of Organization, Functions, 

and Delegations of Authority 

Part C (Centers for Disease Control 

and Prevention) of the Statement of 

Organization, Functions, and 

Delegations of Authority of the 

Department of Health and Human 

Services (45 FR 67772–76, dated 

October 14, 1980, and corrected at 45 FR 

69296, October 20, 1980, as amended 

most recently at 75 FR 2282 1–29, dated 

April 30, 2010) is amended to establish 

the Human Capital Management Office, 

Office of the Chief Operating Officer, 

Centers for Disease Control and 

Prevention. 

Section C–B, Organization and 

Functions, is hereby amended as 

follows: 

After the mission statement for the 

Office of Health and Safety (CAJP), 

insert the following: 

Human Capital Management Office 

(CAJQ). (1) Develops goals and 

objectives and provides leadership, 

policy formation, oversight, and 

guidance in program human capital 

planning and development; (2) plans, 

directs, and manages CDC-wide training 

programs; (3) develops, designs, and 

implements a comprehensive strategic 

human resource leadership and career 

management program for all 

occupational series throughout CDC; (4) 

provides technical assistance in 

organizational development, career 

management, employee development, 

and training; (5) maximizes economies 

of scale through systematic planning 

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28812 Federal Register / Vol. 75, No. 99 / Monday, May 24, 2010 / Notices 

and evaluation of agency-wide training 

initiatives to assist CDC employees in 

achieving required competencies; (6) 

assists in the definition and analysis of 

training needs and develops and 

evaluates instructional products 

designed to meet those needs; (7) works 

with partners, internally and externally, 

to develop a strategic vision for the 

public health workforce; (8) collaborates 

with CDC partners to develop workforce 

goals for all of CDC/ATSDR; (9) 

provides guidance and oversight to the 

Excellence in Learning Council to 

coordinate, inform, and share strategic 

vision for all of CDC’s Centers/Institute/ 

Offices (CIOs); (10) conducts internal 

succession planning, forecasting 

services, and environmental scanning to 

ascertain both current and future public 

health workforce needs; (11) provides 

leadership, oversight, and guidance in 

the management and operations of 

programs; (12) collaborates as 

appropriate, with the CDC Office of the 

Director (OD), CIOs, domestic and 

international agencies and organizations 

and provides a focus for short- and longterm planning within the Human 

Capital Management Office (HCMO); 

(13) conducts organizational 

assessments of CDC/ATSDR to 

determine compliance with agency 

guidance, regulatory and statutory 

requirements of federal human capital 

programs and initiatives; (14) conducts 

organizational studies of human capital 

policies, initiative or procedures as 

directed by OPM, HHS, CDC or other 

pertinent federal agencies; and (15) 

administers, develops policy and 

provides oversight of agency individual 

learning accounts (ILAs) and individual 

development plans (IDPs), performance 

management and other human capital 

programs. 

Office of the Director (CAJQ1). (1) 

Provides leadership and overall 

direction for HCMO; (2) develops goals 

and objectives, and provides leadership, 

policy formation, scientific oversight, 

and guidance in program planning and 

development; (3) plans, coordinates, 

and develops research plans for HCMO; 

(4) uses modeling and forecasting tools 

for workforce planning and decision 

making; (5) coordinates all program 

reviews; (6) reviews, prepares, 

coordinates, and develops proposed 

legislation, Congressional testimony, 

and briefing materials; (7) assists 

programs in establishing performance 

metrics and coordinates quarterly 

reviews with programs to ascertain 

status on meeting of the metrics; (8) 

coordinates budget formulation/ 

negotiation related to program 

initiatives and goals management; (9) 

identifies relevant scanning/ 

benchmarking on workforce and career 

development processes, services and 

products; (10) provides leadership and 

guidance on new developments and 

national trends for public health 

workforce; (11) establishes policies 

governing major learning initiatives and 

new learning activities, and works 

collaboratively within CDC and other 

components in planning, developing 

and implementing policies related to 

training initiatives, including but not 

limited to, ILAs, IDPs, and loan 

repayment programs; (12) develops 

unified CDC-wide administrative 

systems and advocates and supports the 

commitment of resources to application 

development; (13) coordinates 

management information systems and 

analyses of data for improved utilization 

of resources; and (14) directs systems 

analysis and design, programming, and 

systems training as it relates to 

implementation of new and existing 

administrative, management, and 

executive information systems. 

Planning and Policy Activity 

(CAJQ13). (1) Provides leadership, 

guidance, and consulting services for 

CDC on strategic workforce planning, 

performance management, and 

organizational development; (2) directs 

improvement in human capital 

programs with the objectives of 

increasing the operational effectiveness 

and efficiency of agency human capital 

initiatives, mission, goals and 

objectives; (3) serves as a bridge 

between human capital management 

and budgeting and financial 

management by using human capital 

performance metrics and information to 

support budget requests, and 

performance results for financial 

accountability; (4) assesses the impact of 

human capital initiatives; (5) promotes, 

supports, and advocates for strategic 

human capital management concerns 

and initiatives; (6) assesses the 

effectiveness of human capital policies 

and procedures focused on achieving 

organizational outcomes and ensuring 

strategic alignment; (7) provides policy 

and operational direction to workforce 

and career development programs 

across CDC; (8) promotes, supports, and 

advocates for quality education and 

training, workforce diversity, policy, 

and other initiatives needed to develop 

and maintain a vital public health 

workforce and a culture of excellence in 

learning; (9) provides a forum for 

information exchange among the 

workforce and career development 

officers, AHRC, CDC/OD, and other 

public health workforce development 

stakeholders; (10) develops and 

implements administrative policies, 

procedures, and operations, as 

appropriate for CDC/ATSDR, and 

prepares special reports and studies for 

the CDC/OD; and (11) provides 

guidance and oversight on the 

development of policies, procedures 

and processes associated with agency 

awards. 

Human Capital Planning Branch 

(CAJQB). (1) Participates with 

management in program planning, 

policy determination, evaluations, 

budget and decisions concerning the 

division; (2) works with AHRC, Office of 

the Chief Operating Officer, CDC 

Excellence in Learning Council, 

workforce and career development 

officers, and agency managers to carry 

out human capital management 

planning and development activities; (3) 

establishes, coordinates development 

and monitors implementation of the 

human capital accountability system 

framework for management of the 

human capital management plan; (4) 

ensures strategic alignment with OPM’s 

Human Capital Assessment and 

Accountability Framework and HHS’ 

associated procedures and deliverables; 

(5) identifies mission-critical 

occupations and their associated 

competencies to assess potential ‘‘gaps’’ 

in occupations and competencies that 

are essential to CDC achieving its 

strategic goals; (6) reports progress in 

meeting human capital management 

improvement objectives associated with 

the President’s Management Agenda 

and other related government-wide 

human capital initiatives; (7) 

coordinates implementation of a 

succession plan for key leadership and 

technical positions with an emphasis on 

mission-critical occupations; (8) 

develops an agency-wide strategic 

hiring plan that includes recruitment 

and retention strategies to facilitate 

hiring members of under-represented 

groups and those with the requisite 

professional/scientific skills for closing 

occupational series and/or competency 

gaps in the workforce; and (9) provides 

information on Commissioned Corps 

pay, benefits, performance management, 

assignments, retirement, etc., to 

members of the Corps and CDC 

management, and coordinates the 

Commissioned Corps promotion and 

award programs. 

Training and Career Development 

Branch (CAJQC). (1) Plans, directs, 

implements, supports, and coordinates 

the activities of the branch; (2) provides 

agency-wide leadership and guidance in 

all functional areas related to training 

and career development; (3) participates 

with management in program planning, 

policy determination, evaluations, 

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Federal Register / Vol. 75, No. 99 / Monday, May 24, 2010 / Notices 28813 

budget and decisions; (4) designs, 

develops, implements and evaluates a 

comprehensive strategic human 

resource leadership and career training 

and development program for all 

occupational series throughout CDC; (5) 

develops and implements training 

strategies and activities that contribute 

to the agency’s mission, goals and 

objectives; (6) maintains employee 

training records; (7) maximizes 

economies of scale through systematic 

planning and evaluation of agency-wide 

training initiatives to assist CDC 

employees in achieving required 

competencies; (8) develops and 

validates occupational and functional 

competencies and develops related 

training plans; (9) develops and 

administers intern and professional 

development programs, the long-term 

training program, and the mentoring 

program; (10) administers and monitors 

the Training and Learning Management 

System for compliance with the 

Government Employees Training Act; 

(11) conducts training needs assessment 

of CDC employees nationwide and 

provides analysis and data to correlate 

individual training with corporate 

strategic plans; (12) develops and 

maintains assessment tools to identify 

core competency requirements for each 

occupational series throughout the 

agency; (13) provides consultation, 

guidance, and technical assistance to 

managers and employees in 

organizational development, career 

management, employee development, 

and training; (14) develops and delivers 

education and training programs to meet 

the identified needs of the public health 

workforce; (15) promotes, develops, and 

implements training needs assessment 

methodology to establish priorities for 

training interventions; (16) collaborates, 

as appropriate, with the CDC/OD, other 

CIOs, HHS, OPM and other domestic 

and international agencies and 

organizations; and (17) develops and 

implements policies related to employee 

training. 

Dated: May 12, 2010. 

William P. Nichols, 

Chief Operating Officer, Centers for Disease 

Control and Prevention. 

[FR Doc. 2010–12347 Filed 5–21–10; 8:45 am] 

BILLING CODE 4163–18–M 

DEPARTMENT OF HOUSING AND 

URBAN DEVELOPMENT 

[Docket No. FR–5376–N–41] 

Capital Advance Program Submission 

Requirements for the Section 202 

Supportive Housing for the Elderly and 

the Section 811 Supportive Housing 

for Persons With Disabilities 

AGENCY: Office of the Chief Information 

Officer, HUD. 

ACTION: Notice. 

SUMMARY: The proposed information 

collection requirement described below 

has been submitted to the Office of 

Management and Budget (OMB) for 

review, as required by the Paperwork 

Reduction Act. The Department is 

soliciting public comments on the 

subject proposal. 

This collection facilitates the 

processing of all Sections 202 and 811 

capital advance projects from firm 

commitment through final closing. 

Second, it allows for the collection of 

information under the mixed-finance 

section of this program so that those 

owners who wish to partner with forprofit limited partners can participate in 

the development and management of 

supportive housing. And lastly, it 

allows for the collection of information 

to satisfy the reporting requirements for 

owners who receive predevelopment 

grant funds. 

DATES: Comments Due Date: June 23, 

2010. 

ADDRESSES: Interested persons are 

invited to submit comments regarding 

this proposal. Comments should refer to 

the proposal by name and/or OMB 

approval Number (2502–0470) and 

should be sent to: HUD Desk Officer, 

Office of Management and Budget, New 

Executive Office Building, Washington, 

DC 20503; fax: 202–395–5806. 

FOR FURTHER INFORMATION CONTACT: 

Leroy McKinney, Jr., Reports 

Management Officer, QDAM, 

Department of Housing and Urban 

Development, 451 Seventh Street, SW., 

Washington, DC 20410; e-mail Leroy 

McKinney, Jr. at 

Leroy.McKinneyJr@hud.gov or telephone 

(202) 402–5564. This is not a toll-free 

number. Copies of available documents 

submitted to OMB may be obtained 

from Mr. McKinney. 

SUPPLEMENTARY INFORMATION: This 

notice informs the public that the 

Department of Housing and Urban 

Development has submitted to OMB a 

request for approval of the Information 

collection described below. This notice 

is soliciting comments from members of 

the public and affected agencies 

concerning the proposed collection of 

information to: (1) Evaluate whether the 

proposed collection of information is 

necessary for the proper performance of 

the functions of the agency, including 

whether the information will have 

practical utility; (2) Evaluate the 

accuracy of the agency’s estimate of the 

burden of the proposed collection of 

information; (3) Enhance the quality, 

utility, and clarity of the information to 

be collected; and (4) Minimize the 

burden of the collection of information 

on those who are to respond; including 

through the use of appropriate 

automated collection techniques or 

other forms of information technology, 

e.g., permitting electronic submission of 

responses. 

This notice also lists the following 

information: 

Title of Proposal: Capital Advance 

Program Submission Requirements for 

the Section 202 Supportive Housing for 

the Elderly and the Section 811 

Supportive Housing for Persons With 

Disabilities. 

OMB Approval Number: 2502–0470. 

Form Numbers: HUD–: 92013; 92013– 

Supp; 90169–CA, 91732–A–CA; 

90169.A–CA; 92442–CA; 92442–A–CA; 

2328; 92457; 51994; 2530; 92434–CA; 

92435–CA; 2880; 935.2; 9832; 9839–A; 

9839–B; 9839–C; 2453.1–CA; 90179–CA; 

90172–A–CA; 90172–B–CA; 90167–CA; 

92403–CA; 90164–CA; 92452–A; 92452– 

A–CA; 92450–CA; 2554; 92466.1–CA; 

92466–CA; 90163–CA; 90163.1–CA; 

90165–CA; 92443–CA; 92403.1; 90177– 

CA; 90170–CA; 92464; 92329; 90164– 

CA; 92264; 90166–CA; 90166–A–CA; 

92433–CA; 93566–CA; 93432–CA; 

90178–CA; 92485; 92476–A; 92476–A– 

CA; 92448; 92437; 93479; 93480; 93481; 

92458; 90173–A–CA; 90173–B–CA; 

90173–C–CA; 92330–A; 92330; 92331; 

92580–CA; 90175–CA; 90171–CA; 

90176–CA; 92466–CA; 93566–CA; 

90175.1–CA; 93566.1–CA; 27054; 

50080–CAH, SF–269; SF–1199; SF–LLL; 

and FM–1006. 

Description of the Need for the 

Information and Its Proposed Use: This 

collection facilitates the processing of 

all Sections 202 and 811 capital advance 

projects from firm commitment through 

final closing. Second, it allows for the 

collection of information under the 

mixed-finance section of this program 

so that those owners who wish to 

partner with for-profit limited partners 

can participate in the development and 

management of supportive housing. 

And lastly, it allows for the collection 

of information to satisfy the reporting 

requirements for owners who receive 

predevelopment grant funds. 

Frequency of Submission: On 

occasion, Monthly. 

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