Exhibit 10.2
                                                                    ------------
                              MACROCHEM CORPORATION

                               Option Certificate
                               ------------------

     Stock option (the "Option") granted by MacroChem Corporation, a Delaware
corporation with its principal office at 110 Hartwell Avenue, Lexington, MA
02173 (the "Company"), to Robert J. DeLuccia, whose address is 22 Camelot Court,
North White Plains, New York 10603 (the "Optionee").

1.   GRANT OF OPTION
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     This certificate evidences the grant, subject to the Optionee's execution
of an employment agreement by and between the Optionee and the Company (the
"Employment Agreement"), by the Company on June 20, 2003, to the Optionee of an
Option to purchase, in whole or in part, on the terms provided herein, a total
of 500,000 shares of Common Stock of the Company (the "Shares"), par value $.01
per share (the "Stock"), at $1.06 per share, the average price on the date of
grant, June 20, 2003. This Option is not intended to qualify as an incentive
stock option within the meaning of Section 422A of the U.S. Internal Revenue
Code of 1986, as amended. The latest date on which this Option may be exercised
(the "Final Exercise Date") is June 20, 2013.

     This Option will vest in the following installments prior to the Final
Exercise Date:

                  Date                           Number of Shares
                  ----                           ----------------
             June 20, 2003                           150,000
             June 20, 2004                           175,000
             June 20, 2005                           175,000

2.   EXERCISE OF OPTION
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     Each election to exercise this Option, in whole or in part, shall be in
writing, signed by the Optionee, by the Holder, and received by the Company at
its principal office, accompanied by payment in full of an amount equal to the
Exercise Price multiplied by the number of Shares for which this Option is
exercised (the "Purchase Price") and by such additional documentation evidencing
the right to exercise (or, in the case of a Legal Representative, the authority
of such person) as the Company may require. The Purchase Price may be paid (i)
in cash or by personal check, bank check or money order payable to the order of
the Company, or (ii) by delivery of an unconditional and irrevocable undertaking
by a broker to deliver promptly to the Company sufficient funds to pay the
exercise price, or (iii) by delivery of shares of Stock of the Company which
have been outstanding for at least six (6) months (unless the Compensation
Committee of the Board of Directors of the Company (the "Committee") approves a
shorter period) and which have a fair market value equal to the exercise price,
or (iv) by any combination of the permissible forms of payment. For purposes of

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this Option, the term "Holder" shall mean the Optionee or the person or persons
to whom this Option is transferred in accordance with the provisions of this
Option (including by will or the applicable laws of descent and distribution).
For purposes of this Option, the term "Legal Representative" shall mean the
person designated to exercise this Option upon the Holder's death or disability.

3.   ACCELERATION UPON A CHANGE OF CONTROL
     -------------------------------------
     In the event that the Optionee's employment is terminated by the Company
other than for Cause or the Optionee terminates his employment for Good Reason,
in each case at any time subsequent to a Change of Control, this Option will
become immediately exercisable with respect to all Shares and remain exercisable
until the Final Exercise Date. "Cause", "Good Reason," and "Change of Control"
shall have the meanings provided in the Employment Agreement.

4.   STATUS CHANGE
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     Except as provided in Section 3, upon the cessation of the Optionee's
employment for any reason (a "Status Change"), this Option shall terminate as to
any Shares for which it was not exercisable immediately prior to the Status
Change; provided, that the Committee in its sole discretion may provide (either
prior to or following the Status Change) that any or all of such portion of this
Option not otherwise exercisable prior to the Status Change shall be treated as
having become exercisable immediately prior to the Status Change. As to that
number of Shares for which the Option was exercisable (or deemed exercisable by
action of the Committee) immediately prior to the Status Change, it shall remain
exercisable as follows:

     (i) if the Status Change occurs for any reason other than death, for a
     period of six (6) months following the date of the Status Change, except as
     provided in clauses (ii), (iii) and (iv) below (but in no event beyond the
     Final Exercise Date), or

     (ii) if the Status Change results from (x) retirement of the Optionee on or
     after age 65, (y) retirement on or after age 55 after ten (10) years of
     continuous employment by the Company or (z) disability (as determined by
     the Company), until the Final Exercise Date, or

     (iii) if the Status Change results from (x) termination of employment by
     the Company other than for Cause, or (y) termination of employment by the
     Optionee for Good Reason, and the Optionee remains a member of the
     Company's Board of Directors following such Status Change, until the
     earlier of (a) the Final Exercise Date or (b) six (6) months following the
     date the Optionee ceases to be a member of the Company's Board of
     Directors, or

     (iv) if the Status Change results from (x) termination of employment by the
     Company other than for Cause, or (y) termination of employment by the
     Optionee for Good Reason, and, in connection with such Status Change, the
     Optionee ceases to be a member of the Company's Board of Directors, until
     the earlier of (a) the Final Exercise Date or (b) the first anniversary of
     the effective date of such Status Change, or

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     (v) following death, for a period of one year ending upon the first
     anniversary of the Optionee's death, not to extend beyond the Final
     Exercise Date, or

     (vi) such other date as is determined by the Committee at any time prior to
     the exercise of this Option (but in no event beyond the Final Exercise
     Date).

Notwithstanding the foregoing or Section 3, if the Optionee is terminated for
Cause pursuant to the Employment Agreement, this Option shall immediately
terminate simultaneously with the termination of the Optionee's employment.

5.   NONTRANSFERABILITY OF OPTION
     ----------------------------
     This Option may not be transferred other than by will or by the laws of
descent and distribution, and during the Optionee's lifetime may be exercised
only by the Optionee (or in the event of the Optionee's incapacity, the person
or persons legally appointed to act on the Optionee's behalf), except that this
Option may be transferred to (i) Immediate Family Members, (ii) a trust or
trusts for the exclusive benefit of Immediate Family Members, or (iii) a
partnership in which such Immediate Family Members are the only partners,
provided that (x) there may be no consideration for any such transfer and (y)
subsequent transfers of this Option shall be prohibited except those made in
accordance with this Section 5. Following such transfer, this Option shall
continue to be subject to all the terms and conditions hereof. "Immediate Family
Members" shall mean the spouse, children and grandchildren of the Optionee.

6.   RIGHTS AS A STOCKHOLDER
     -----------------------
     This Option will not give the Holder rights of a stockholder; the Holder
will obtain such rights upon actual receipt of the Shares. However, the
Committee may, on such conditions as it deems appropriate, provide that the
Holder will receive a benefit in lieu of cash dividends that would have been
payable on any or all Shares subject to the Option had such Shares been
outstanding. Without limitation, the Committee may provide for payment to the
Holder of amounts representing such dividends, either currently or in the
future, or for the investment of such amounts on behalf of the Holder.

7.   ADJUSTMENTS
     -----------
     In the event of a stock dividend, stock split or combination of shares,
recapitalization or other change in the Company's capital structure, the
Committee will make appropriate adjustments to the number of Shares that may be
delivered under this Option, and will also make appropriate adjustments to the
number and kind of Shares subject to the Option then outstanding or subsequently
granted, any exercise price relating to the Option and any other provision of
the Option affected by such change.

     The Committee may also make adjustments of the type described above to take
into account distributions to common stockholders, or any other event, if the
Committee determines that adjustments are appropriate to avoid distortion in the
operation of the Option and to preserve the value of the Option made hereunder.

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8.   REORGANIZATION
     --------------
     In the event of a transaction by the Company in which there is an acquiring
or surviving entity (a "Covered Transaction"), the Committee may provide for the
assumption of the Option, or for the grant of a new option in substitution
therefor, by the acquirer or survivor or an affiliate of such acquirer or
survivor, in each case on such terms and subject to such conditions as the
Committee determines; provided, that in the absence of such an assumption, or if
there is no surviving or acquiring entity, the Option shall become fully
exercisable at least twenty (20) days prior to the Covered Transaction and shall
terminate upon consummation of the Covered Transaction.

9.   WITHHOLDING TAXES
     -----------------
     The Committee will have the right to require that the Holder or other
appropriate person remit to the Company an amount sufficient to satisfy the
withholding requirements or make other arrangements satisfactory to the
Committee with regard to such requirements, prior to the delivery of any Shares.
The Committee may, but need not, hold back Shares or permit the Holder to tender
previously owned shares of Stock of the Company in satisfaction of tax
withholding requirements.

10.  GENERAL PROVISIONS
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          (a) Amendment of Option. This Option may not be modified or amended
     except by an instrument in writing signed by the Company and the Holder.

          (b) Governing Law. This Option and the respective rights and
     obligations of the parties hereunder shall be governed by, and construed in
     accordance with, the laws of the Commonwealth of Massachusetts (without
     giving effect to the conflict of law principles thereof).

          (c) Notices. Notices, demands and all other communications provided
     for in this Option shall be in writing and shall be deemed to have been
     duly given when delivered, if delivered personally, or (unless otherwise
     specified) mailed by United States certified or registered mail, return
     receipt requested, postage prepaid, and when received if delivered
     otherwise, addressed as set forth in the first paragraph of this Option or
     to such other address as any party may have furnished to the other in
     writing in accordance herewith, except that notices of change of address
     shall be effective only upon receipt.


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     IN WITNESS THEREOF, the Company has caused this Option to be executed under
its corporate seal by its duly authorized officer. This Option shall take effect
as a sealed instrument.

                                                    MACROCHEM CORPORATION


                                                    By: /s/ John Zabriskie
                                                        ------------------
                                                    Name: John Zabriskie
                                                    Title: Chairman of the Board

Accepted and Agreed:
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/s/ Robert J. DeLuccia
--------------------------
Name: Robert J. DeLuccia

Dated:     09/11/03
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