Exhibit 10.3





Exhibit 10.3




EXECUTION COPY




AMENDMENT NO. 1

TO

DEVELOPMENT AND COMMERCIALIZATION AGREEMENT




THIS AMENDMENT NO. 1 (the “Amendment”), dated January 16, 2009, amends that certain
Development and Commercialization Agreement, dated as of January 4, 2009 (the “Development
Agreement”), by and between La Jolla Pharmaceutical Company, a Delaware corporation (the
“Company”), and BioMarin CF Limited, an Irish corporation (“BioMarin CF”).



RECITALS




A. WHEREAS, in connection with the Development Agreement, the Company and BioMarin
Pharmaceutical Inc., a Delaware corporation (“BioMarin Pharmaceutical”), entered into that
certain Securities Purchase Agreement, dated as of January 4, 2009 (the “Securities Purchase
Agreement”);



B. WHEREAS, the Company and BioMarin Pharmaceutical have made certain changes to the
Securities Purchase Agreement in the form of an amendment to the Securities Purchase Agreement (the
“Amendment to the Securities Purchase Agreement”); and



C. WHEREAS, the Company and BioMarin CF desire to make conforming changes to the Development
Agreement to reflect certain changes made by the Amendment to the Securities Purchase Agreement.



NOW, THEREFORE, in consideration of the foregoing, the parties agree as follows:



1. Section 1.41 of the Development Agreement is amended and restated in its entirety as
follows:




“1.41 “Securities Purchase Agreement” shall mean the form of securities purchase
agreement, as amended by the Amendment to the Securities Purchase Agreement, each as attached
to this Agreement as Exhibit 1.41.”



2. Exhibit 1.41 to the Development Agreement shall be amended and restated in its
entirety in the form of Exhibit 1.41 attached hereto.



3. Undefined capitalized terms used in this Amendment shall have the meanings ascribed to them
in the Development Agreement.



4. Except as expressly set forth in this Amendment, all other terms of the Development
Agreement shall remain in full force and effect and once this Amendment is executed by the parties
hereto, all references in the Development Agreement to “the Agreement” or “this Agreement,” as
applicable, shall refer to the Development Agreement, as modified by this Amendment.



5. This Amendment shall be governed by and construed in accordance with the laws of the State
of California applicable to contracts made and to be performed entirely within such State without
regard to conflict of laws principles thereof.



6. This Amendment may be executed in any number of counterparts and each of such counterparts
shall for all purposes be deemed to be an original, and all such counterparts shall together
constitute but one and the same instrument.



* * *




 


 









 







IN WITNESS WHEREOF, the Parties have caused this Amendment to be executed as of the date first
set forth above.



 



	 	 	 	 	 	 	 	 	 
	LA JOLLA PHARMACEUTICAL COMPANY	 	 	BIOMARIN CF LIMITED
	 
	 	 	 	 	 	 	 	 
	By: 

	/s/ Deirdre Y. Gillespie
	 	 	By: 
	/s/ G. Eric Davis
	 

	 
	 	 	 	 
	 

	Name: 	Deirdre Y. Gillespie, M.D.
	 	 	 	Name:
	 	G. Eric Davis
	 

	Title: 	President and Chief Executive Officer
	 	 	 	Title:
	 	Managing Director






 


 









 





Exhibit 1.41 




Securities Purchase Agreement




[Filed as Exhibit 10.30 to BioMarin’s Annual Report on Form 10-K

for the year ended December 31, 2008]