EXHIBIT 31.1

SECTION 302
CERTIFICATION

I, Michael
I. Ruxin, M.D., certify that:

1.  
I have reviewed this Annual Report on Form 10-KSB of Global Med Technologies, Inc.
(the "Registrant);

2. Based
on my knowledge, this annual report does not contain any untrue statement of a material
fact or omit to state a material fact necessary to make the statements made, in light
of the circumstances under which such statements were made, not misleading with respect
to the period covered by this report;

3. Based
on my knowledge, the financial statements, and other financial information included
in this report, fairly present in all material respects the financial condition,
results of operations and cash flows of the Registrant as of, and for, the periods
presented in this report;

4. The
Registrants other certifying officers and I are responsible for establishing
and maintaining disclosure controls and procedures (as defined in Exchange Act Rules
13a-15(e) and 15d-15(e)) and internal control over financing reporting (as defined
in Exchange Act Rules 13a-15(f) and 15d-15(f) for the Registrant and we have:

a) Designed
such disclosure controls and procedures, or caused such disclosure controls and procedures
to be designed under our supervision, to ensure that material information relating
to the Registrant, including its consolidated subsidiaries, is made known to us by
others within those entities, particularly during the period in which this annual
report is being prepared;

b) Designed
such internal controls over financial reporting, or caused such internal control
over financial reporting to be designed under our supervision, to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of
financial statements for external purposes in accordance with generally accepted
accounting principles; c) Evaluated the effectiveness of the Registrants disclosure
controls and procedures and presented in this report our conclusions about the effectiveness
of the disclosure controls and procedures, as of the end of the period covered by
this report based on such evaluation; and

d) Disclosed
in this Report any change in the Registrants internal control over financial
reporting that occurred during the Registrants most recent fiscal quarter (the
Registrants fourth fiscal quarter in the case of an annual report) that has
materially affected, or is reasonably likely to materially affect, the Registrants
internal control over financial reporting; and

5. The
registrants other certifying officers and I have disclosed, based on our most
recent evaluation of internal control over financial reporting,, to the Registrants
auditors and the audit committee of Registrants board of directors (or persons
performing the equivalent function):

a) All
significant deficiencies and material weaknesses in the design or operation of internal
control over financial reporting which are reasonably likely to adversely affect
the Registrants ability to record, process, summarize and report financial
information; and

b) Any
fraud, whether or not material, that involves management or other employees who have
a significant role in the registrants internal controls.

| | /s/ Michael I. Ruxin, M.DName: Michael I. Ruxin, M.DChief
     Executive Officer
| | --------------------------------------------------------------------------------

Date:  March 30, 2006

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