Exhibit 12.1

CURAGEN CORPORATION AND SUBSIDIARY

RATIO OF EARNINGS TO FIXED CHARGES

(in thousands, except ratio data)



|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|---------------------------------------------------------------------------- |  | ----------------------- | ------ | ---- | - | ------- | ---- |  | - | ------- | - |  | ---- | ------- | - |  | - | ------- | -
|                                                                             |  | Year Ended December 31, |       
|                                                                             |  | 2008                    |        | 2007 |   |         | 2006 |  |   | 2005    |   |  | 2004 |        
|Loss:                                                                        |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Income (loss) from continuing operations before income tax benefit           |  | $                       | 25,103 |      | $ | (50,148 | )    |  | $ | (57,540 | ) |  | $    | (69,571 | ) |  | $ | (80,770 | )
|Add: Fixed charges                                                           |  |                         | 1,935  |      |   | 5,617   |      |  |   | 9,778   |   |  |      | 12,396  |   |  |   | 13,653  |  
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total income (loss)                                                          |  | $                       | 27,038 |      | $ | (44,531 | )    |  | $ | (47,762 | ) |  | $    | (57,175 | ) |  | $ | (67,117 | )
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Fixed charges:                                                               |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Interest expense on indebtedness (including amortization of financing costs) |  | $                       | 1,687  |      | $ | 5,167   |      |  | $ | 9,351   |   |  | $    | 11,701  |   |  | $ | 12,941  |  
|Estimated interest portion of rental expense                                 |  |                         | 248    |      |   | 450     |      |  |   | 427     |   |  |      | 695     |   |  |   | 712     |  
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total fixed charges                                                          |  | $                       | 1,935  |      | $ | 5,617   |      |  | $ | 9,778   |   |  | $    | 12,396  |   |  | $ | 13,653  |  
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Ratio of Earnings to Fixed Charges                                           |  |                         | 13.97  |      |   | (7.93   | )    |  |   | (4.88   | ) |  |      | (4.61   | ) |  |   | (4.92   | )
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Earnings (Deficiency) of Earnings Available to Cover Fixed Charges           |  | $                       | 25,103 |      | $ | (50,148 | )    |  | $ | (57,540 | ) |  | $    | (69,571 | ) |  | $ | (80,770 | )
|                                                                             |  |                         |        |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |