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NIOSH
 Peer Review: 1-Bromopropane


At a glance
 NIOSH created a peer review plan for a draft recommended exposure limit for 1-Bromopropane. This chemical is a solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP has been linked to neurological illnesses.
 Overview **Title:** Draft NIOSH Criteria for a Recommended Standard: 1-Bromopropane **Subject:** A comprehensive summary of the health risks from exposure to 1-bromopropane. **Purpose:** To describe the extent and characteristics of workplace exposures and to provide strategies for preventing exposure at the work site (engineering controls, personal protective equipment, and a recommended exposure limit). **Timing of Review:** February – April 2016 **Primary Disciplines or Expertise Needed for Review:** Risk assessment, toxicology, epidemiology, industrial hygiene **Type of Review:** Individual **Number of Reviewers:** 6 **Reviewers Selected by:** NIOSH **Public Nominations Requested for Reviewers:** No **Opportunities for the Public to Comment**: Yes **Peer Reviewers Provided with Public Comments Before Their Review:** Yes
 Charge to peer reviewers As part of the review of this draft criteria document, reviewers are asked to address the following critical questions: Does the draft criteria document accurately identify and characterize the health hazards of occupational exposures to 1–bromopropane (1–BP) based on the current understanding of the scientific literature? Please identify any additional relevant literature that NIOSH should consider when developing its recommendations. Is the risk estimation for 1–BP presented in the draft criteria document a reasonable reflection of the current understanding of the scientific literature? Please describe any changes in the risk estimation that NIOSH should consider and provide supporting scientific literature.
Are there other risk assessment methods or health endpoints that NIOSH should consider for estimating risks of 1–BP? Please provide supporting scientific literature or other evidence to support your recommendations.
In this draft criteria document, NIOSH proposes a recommended exposure limit (REL) to prevent a risk of one excess cancer in 1000 workers exposed to 1–BP for a 45-year working lifetime. During development of the draft criteria document, NIOSH also considered setting the REL at a level to prevent 1 excess cancer in 10,000 workers for a 45-year working lifetime. Please comment on the excess cancerrisk level and resulting REL for 1–BP.
Is the relationship between exposure to 1–BP and biological activity (toxicity) accurately presented in the draft criteria document?
Are the recommended strategies for controlling or preventing exposure to 1–BP (e.g., engineering controls, work practices, personal protective equipment) reasonable and technically feasible?
Are there other techniques or technologies capable of controlling workplace exposures to 1–BP that should be discussed in the draft criteria document?
Are the exposure measurement methods and the associated challenges in measuring workplace exposures to 1– BP adequately addressed in the draft criteria document?
Are there medical screening and surveillance measures, such as specific diagnostic tests, guidelines, and metrics, that should be implemented for workers expected of being exposed to 1–BP that are not discussed in the draft criteria document?
Are there biological indices or metrics that should be used to aid in the interpretation of biomonitoring data for 1–BP? What is the most appropriate biomarker that can confirm and quantify occupational exposures to 1–BP?
Should acute exposure recommendations, such as a short term exposure limit (STEL), be derived for 1– BP? If so, what data support the development of the STEL?
NIOSH provided Globally Harmonized System (GHS) of Classification and Labelling of Chemicals designations for health endpoints evaluated in the criteria document. Please comment on the utility of these classifications for hazard communication. Are these classifications helpful for employers?
 Peer reviewers Professor of Pharmacology & Toxicology, University of GeorgiaAreas of expertise: toxicology, pharmacology
 Associate Dean for Nursing, Worcester State UniversityArea of expertise: occupational medicine
 Faculty of Pharmaceutical Sciences, Tokyo University of ScienceArea of expertise: toxicology
 Professor, Department of Pharmacology, Wayne State University School of MedicineAreas of expertise: toxicology, pharmacology
 Chief, Division of Vascular Neurology, University of Utah NeurologyArea of expertise: neurology
 Assistant Professor, Department of Environmental Health Science, University of GeorgiaAreas of expertise: developmental and reproductive toxicology, toxicogenomics
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  May 29, 2024 Sources Print Share
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NIOSH National Institute for Occupational Safety and Health View All
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