Skip directly to site content Skip directly to page options Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
														Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





n-ISOPROPYLAMINE								Related Pages
										*OSHA comments from the January 19, 1989 Final Rule on Air Contaminants Project extracted from 54FR2332 et. seq. This rule was remanded by the U.S. Circuit Court of Appeals and the limits are not currently in force.*
**CAS:** 75-31-0; **Chemical Formula:** (CH3)2CHNH2
OSHA’s previous limit for n-isopropylamine was 5 ppm as an 8-hour TWA. The Agency proposed retaining this TWA limit and adding a 10-ppm 15-minute STEL, based on the ACGIH recommendation. NIOSH (Ex. 8-47, Table N1; Tr. p. 3-86) concurred with this proposal, and these limits are established in the final rule. This substance is a flammable, volatile, colorless liquid that has an odor similar to that of ammonia.
The most serious effect of n-isopropylamine in laboratory animals is respiratory tract irritation, which can be severe enough to cause lung edema (Smyth 1956/Ex. 1-759). Rats survived a four-hour inhalation at 4000 ppm, but an 8000-ppm exposure resulted in fatalities (Smyth, Carpenter, and Weil 1951/Ex. 1-439). Proctor and Hughes (1978/Ex. 1-1136) have reported that the odor of n-isopropylamine becomes strong and unpleasant at the 10- to 20-ppm level; nose and throat irritation is experienced even as a result of brief exposures.
Except for NIOSH, no rulemaking participants commented on OSHA’s proposal to issue a 5-ppm TWA and 15-minute STEL of 10 ppm for this substance. The Agency concludes that both a TWA and STEL are required to protect exposed workers from the significant risk of upper respiratory tract irritation that is known to occur even at brief excursions above the 8-hour PEL. The Agency considers upper respiratory tract irritation resulting from exposure to this substance to be a material impairment of health. Therefore, OSHA is revising the PEL for n-isopropylamine to 5 ppm as an 8-hour TWA and 10 ppm as a 15-minute STEL; these limits are established in the final rule.
										
							
								Page last reviewed:  September 28, 2011						Content source:  	National Institute for Occupational Safety and Health NIOSH
1988 OSHA PEL Project Documentation
Index of Chemical Names
Index of CAS Numbers Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification / Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
				Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
				You will be subject to the destination website's privacy policy when you follow the link.
				CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue