Exhibit 12.1

CURAGEN CORPORATION AND SUBSIDIARY

RATIO OF EARNINGS TO FIXED CHARGES

(in thousands, except ratio data)



|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|---------------------------------------------------------------------------- |  | ----------------------- | ------- | - | ---- | - | ------- | ---- |  | - | ------- | - |  | ---- | ------- | - |  | - | ------- | -
|                                                                             |  | Year Ended December 31, |        
|                                                                             |  | 2007                    |         |   | 2006 |   |         | 2005 |  |   | 2004    |   |  | 2003 |        
|Loss:                                                                        |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Loss from continuing operations before income tax benefit                    |  | $                       | (50,148 | ) |      | $ | (57,540 | )    |  | $ | (69,571 | ) |  | $    | (80,770 | ) |  | $ | (65,580 | )
|Add: Fixed charges                                                           |  |                         | 5,617   |   |      |   | 9,778   |      |  |   | 12,396  |   |  |      | 13,653  |   |  |   | 10,578  |  
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total loss                                                                   |  | $                       | (44,531 | ) |      | $ | (47,762 | )    |  | $ | (57,175 | ) |  | $    | (67,117 | ) |  | $ | (55,002 | )
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Fixed charges:                                                               |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Interest expense on indebtedness (including amortization of financing costs) |  | $                       | 5,167   |   |      | $ | 9,351   |      |  | $ | 11,701  |   |  | $    | 12,941  |   |  | $ | 9,845   |  
|Estimated interest portion of rental expense                                 |  |                         | 450     |   |      |   | 427     |      |  |   | 695     |   |  |      | 712     |   |  |   | 733     |  
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Total fixed charges                                                          |  | $                       | 5,617   |   |      | $ | 9,778   |      |  | $ | 12,396  |   |  | $    | 13,653  |   |  | $ | 10,578  |  
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Ratio of Earnings to Fixed Charges                                           |  |                         | (7.93   | ) |      |   | (4.88   | )    |  |   | (4.61   | ) |  |      | (4.92   | ) |  |   | (5.20   | )
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |  
|Deficiency of Earnings Available to Cover Fixed Charges                      |  | $                       | (50,148 | ) |      | $ | (57,540 | )    |  | $ | (69,571 | ) |  | $    | (80,770 | ) |  | $ | (65,580 | )
|                                                                             |  |                         |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |         |