Skip directly to site content Skip directly to page options Skip directly to A-Z link


Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People
														Search
		×
			NIOSH
			NIOSH
				All CDC
				Submit
			For a full list of topics:A-Z Index
			Advanced Search
		Advanced Search


The National Institute for Occupational Safety and Health (NIOSH)


Facebook
        Twitter
        LinkedIn
        Syndicate





N-ISOPROPYLANILINE								Related Pages
										*OSHA comments from the January 19, 1989 Final Rule on Air Contaminants Project extracted from 54FR2332 et. seq. This rule was remanded by the U.S. Circuit Court of Appeals and the limits are not currently in force.*
**CAS:** 768-52-5; **Chemical Formula:** C6H5NHCH(CH3)2
OSHA formerly had no limit for N-isopropylaniline. The ACGIH recommends a TLV-TWA of 2 ppm, with a skin notation, for this liquid. The proposed PEL was 2 ppm, with a skin notation; NIOSH (Ex. 8-47, Table N1) concurs. The final rule establishes an 8-hour TWA PEL of 2 ppm, and a skin notation, for N-isopropylaniline.
The oral LD(50) for rats exposed to N-isopropylaniline is between 0.25 and 0.5 g/kg. Slight irritation of the skin and eyes has been reported in animals as a result of direct contact with this chemical (Dow Chemical Company 1977k, as cited in ACGIH 1986/Ex. 1-3, p. 338). No other data concerning chronic toxicity or human exposure are available (ACGIH 1986/Ex. 1-3, p. 338).
Chemical analysis shows N-isopropylaniline to have toxicologic properties similar to those of its parent compound, aniline. The oral LD(50)s for the two chemicals are approximately equal. The ACGIH has established the 2-ppm TLV-TWA for N-isopropylaniline on the basis of its structural analogy with aniline (which has a 2-ppm TLV-TWA) and N,N-dimethylaniline (which has a 5-ppm TLV-TWA and a 10-ppm STEL); exposure to these substances has been shown to cause hemolytic and central nervous system effects in animals and humans. These substances are also toxic when absorbed through the skin. OSHA received only one comment, from NIOSH, on this substance.
In the final rule, OSHA is establishing an 8-hour PEL of 2 ppm for N-isopropylaniline, with a skin notation. The Agency concludes that this limit will protect exposed workers from the significant risk of irritation and systemic and hemolytic effects, all material health impairments that are caused by inhalation, ingestion, or dermal absorption of N-isopropyl-aniline.
										
							
								Page last reviewed:  September 28, 2011						Content source:  	National Institute for Occupational Safety and Health NIOSH
1988 OSHA PEL Project Documentation
Index of Chemical Names
Index of CAS Numbers Follow NIOSH Facebook
Pinterest
Twitter
YouTube
 NIOSH Homepage NIOSH A-Z
Workplace Safety & Health Topics
Publications and Products
Programs
Contact NIOSH


About CDC
					Contact Us
					800-232-4636
 Facebook Twitter Instagram LinkedIn Youtube Pinterest Snapchat
 CONTACT CDC
				Contact Us
							Call 800-232-4636
							Email Us
			ABOUT CDC
				About CDC
							Jobs
							Funding
			POLICIES
				Accessibility
							External Links
							Privacy
							Policies
							No Fear Act
							FOIA
							OIG
							Nondiscrimination
							Vulnerability Disclosure Policy
			CONNECT WITH US
				Facebook
								Twitter
								Instagram
								LinkedIn
							Youtube
								Pinterest
								Snapchat
								Email
			LANGUAGES
				Español
							繁體中文
							Tiếng Việt
							한국어
							Tagalog
							Русский
							العربية
							Kreyòl Ayisyen
							Français
							Polski
							Português
							Italiano
							Deutsch
							日本語
							فارسی
							English


U.S. Department of Health & Human Services
			Accessibility
			External Links
			Privacy
			Policies
			No Fear Act
			FOIA
			Nondiscrimination
			OIG
			Vulnerability Disclosure Policy
			USA.gov


Exit Notification / Disclaimer Policy Close
 Links with this icon  indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
				Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
				You will be subject to the destination website's privacy policy when you follow the link.
				CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Website Disclaimers
 Cancel Continue