CTCA: Multiple Myeloma Treatment Page 2 of 2

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Cancer Treatment Centers of America: Multiple Myeloma Treatment

At CTCA, treatment for multiple myeloma depends on your age, the stage of your
multiple myeloma, your overall health and a variety of other factors. Your multiple
myeloma treatment may include intensity modulated radiation therapy, fractionated
dose chemotherapy, and autologous stem cell rescue with post transplant
immunotherapy. In addition to these traditional treatment forms, your multiple
myeloma treatment may include complementary and alternative therapies.
Multiple Myeloma - More Information

To learn more about multiple myeloma, please visit our Multiple Myeloma Cancer

Center at this link: Multiple Myeloma & CTCA. You can also gain valuable
information about multiple myeloma by visiting our homepage.

Additional Cancer Information And Resources

Don't miss this additional information on » Site
multiple myeloma. Click on the links to the right 6
to learn more about breast cancer or call 1- > h
800-615-3055 to discuss your treatment
options with one of our Oncology Information
Specialists.

URL: http://www.cancercenter.com

Call 800-615-3055 for a free, no-obligation conversation with one of our Oncology Information
Specialists.

Our representatives are available 24 hours a day, every day.

All materials copyright © 2008 International Capital & Management Company, LLLP. All rights
reserved.

http: ://Awww.cancercenter.com/multiple-myeloma.htm 2/20/2008


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@ increducuon a Sereening and dlagnases ahh
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8 a Treatment
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When to seek medical advice w Coping skills

Multiple myeloma isn't contagious. Most people who develop multiple
myeloma have no clearly identifiable risk factors for the disease.

Some factors that may increase your risk of multiple myeloma include:

2. =. Age.,The majority of people who develop multiple myeloma are older
than 50, with most diagnosed around age 70. Few cases occur in
people younger than 40. .

Y Lin Sex. Men are more likely to develop the disease than are women.

MV a Race, Blacks are about twice as likely to develop multiple tnyeloma
‘ as are whites.

y » History ofa monacional gammopathy of undetermined
significance. Every year 1 percent of the people with MGUS in the

United States develop multiple myeloma. Get th e
= Obesity. Your risk of multiple myeloma is increased if you're ' F
wv See ty oo obese wes Jin fo avery ¢ facts about

Other factors that may increase your risk of developing multiple myeloma, wat multiple
include exposure to radiation and working in petroleum-related industries. at- al yelo ma
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Find out more

RELATED
s Monoclonal gammopathy:

s iLcancer?

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sections
Sa) E-mail thus
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hitp://www.mayoclinic.com/health/muitiple-myeloma/DS0041 5/DSECTION=4 1/11/2008



er

Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention
lliness Compensation Act National institute for Occupational Safety and Health

OMB Number; 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Page 5 of 7
F Basis for Proposing that Records and Information are Inadequate for Individual Dose —
Complete Section F.

Complete at least one of the following entries in this section by checking the appropriate box and providing
the required information related to the selection. You are not required to complete more than one entry.

Fit O IMWe have attached either documents or statements provided by affidavit that indicate that
radiation exposures and radiation doses potentially incurred by members of the proposed class,
that relate to this petition, were not monitored, either through personal monitoring or through area

monitoring.
(Attach documents and/or affidavits to the back of the petition form.)

Describe as completely as possible, to the extent it might be unclear, how the attached
documentation and/or affidavit(s) indicate that potential radiation exposures were not monitored.

F.2 ¥ \ We have attached either documents or statements provided by affidavit that indicate that
tadiation monitoring records for members of the proposed class have been lost, falsified, or
destroyed; or that there is no information regarding monitoring, source, source term, or process
from the site where the employees worked.

(Attach documents and/or affidavits to the back of the petition form.)

Describe as completely as possible, to the extent it might be unclear, how the attached
documentation and/or affidavit(s) indicate that radiation monitoring records for members of the
proposed class have been lost, altered illegally, or destroyed.

2. if slates in fhe attyehed  felfer

0). Fisnig y EL WIALS

J _ Lebo as
haye Deen  estroveds
en _attected js, a page from his

Media] —tebocds lading fete LoD

Part F is continued on the following page.

Name or Social Security Number of First Petitioner: _



ACS: Radiation Exposure and Cancer ; rape ouisr

A number of studies over the past 20 years have looked at the impact of
environmental radiation exposure in the dose range of 10 cGy or less.
Careful analysis of this research revealed no significant increase in the
incidence of all cancers combined, or of cancers in specific parts of the
body. Research in this area is continuing.

Types of Cancer Associated With lonizing Radiation

Leukemia was at one time thought to be the major cancer to arise from
high-dose radiation exposure, based on the experience with people
exposed to the atomic blasts in Japan. It is now known that other cancers
can result from radiation exposure, although they may take fonger to
develop (usually at least 10 to 15 years). Leukemias, by contrast, begin
appearing as eatly as 2 years after acute radiation exposure.

Studies of the survivors of the atomic blasts have demonstrated that high-
dose radiation (at least 100cGy) increases the risk of developing several
types of cancer.

« For these survivors, the risk of developing leukemia is five anda
half times greater than in the general public. Children appear to be
twice as sensifive as adults to the leukemia-causing effects of
radiation, and unborn children exposed to radiation in the uterus
are even more sensitive.

» The risk for developing any type of cancer in those highly exposed
to an atomic blast is about 50% higher than the risk in those not
exposed.

= Female breast cancer risk is more than twice as high as normal,
and women who are exposed when under the age of 20 are found a7) ew
to be at higher risk than older women. an pee NS

«The risk of developing lung cancer is 50% higher, and the risk for e fan ey, @
multiple myeloma is more than twice as high as in the general ~ yer ° Z
population. 2

Some people serving in the armed forces were exposed to radiation in
nuclear weapons testing during the Cold War era. Information on this topic
is available in our document, “Cancer Among Military Personnel Exposed
to Nuclear Weapons.”

Cancers Caused by Radiation Therapy

fonizing radiation is an effective way to treat certain kinds of cancer.
During radiation therapy, high doses of ionizing radiation are directed at
the cancer, resulting in the death of the cancer cells. However, this can
lead to DNA mutations in cells that survive the radiation, which can
eventually lead to the development of another cancer (called a second
primary cancer).

An increase in second primary tumors in the area being irradiated has
been observed in patients with several types of cancer following radiation
therapy and/or chemotherapy. Some studies have associated radiation
therapy with an increased incidence of thyroid cancer and early-onset
breast cancer. Overall, however, radiation lone does not appear to be a
very potent cancer-causing agent in second tumors. This is probably due
to the fact that it is often used in a localized area, which means fewer
normal cells are exposed to radiation.

http://www.cancer.org/docroot/PED/content/PED_1_3X_Radiation_Exposure_and_Cancer.. 2/20/2008



’

Ce

Union Carbide Corporation
A Subsidiary of The Dow Chemical Company

February 27, 2008

This is in response to your letter that I received on February 5, 2008 requesting
information regarding retirement benefit. You also requested
information regarding his employment history at Union Carbide Corporation (“UCC”).

Date of Hire was 1952 and his adjusted Continuous
Service Date at UCC was 1953. This adjustment results from a brief period
where he was laid off. employment ended on 1986 as a result

of the Voluntary Severance Program which included a “3 + 3” pension benefit

enhancement. The “3 + 3” enhancement added an additional 3 years to his age and

service for purposes of pension calculation. When employment at UCC ended,

: actual] age was 52 year, 10 months and actual service was 33 years, 6 months.
\pplication for Retirement Benefits” is enclosed.

elected to commence his pension benefit immediately on 1986.
elected the 50% Joint and Survivor option (enclosed) and also elected the Level Income
option (enclosed). received $2,079.55 per month prior to age 62 and was scheduled to
receive $1,477.55 per month after age 62 but passed away before this benefit became
effective. The survivor pension ($905.78) was based on his pension benefit prior to
processing his Level Income election. pension calculation is enclosed.

passed away on 1994 and your survivor pension ($905.78)
commenced on 1994. It was increased to $955.78 on 2007 as

a result of the recent pension adjustment.

According to our records management schedule, personnel files of employees are kept for
6 years plus the current year after an employee leaves employment. Therefore,

personnel file has been destroyed and I am unable to provide great detail of his
employment history with Union Carbide Corporation. However, there was some
information in his pension file that I can share with you (enclosed).

retired from the Carbon Products division at their facility in Clarksville, TN. His
last position was a Staff Analyst in the Information Technology group. It appears that he



Special Exposure Cohort Petition U.S. Department of Health and Human Services
under the Energy Employees Occupational Centers for Disease Control and Prevention
Mness Compensation Act National Institute for Occupational Safety and Health

OMB Number: 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Appendix — Continuation Page

Continuation Page — Photocopy and complete as necessary.

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16 J00 % impo le tp arucatdy tetonstued.

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Attach to Form B if necessary.

Name or Social Security Number of First Petitioner: _



Special Exposure Cohort Petition U.S. Department of Health and Human Services
Centers for Disease Control and Prevention

National Institute for Occupational Safety and Health

under the Energy Employees Occupational
illness Compensation Act

OMB Number: 0920-0639 Expires: 05/31/2007
Form B Appendix — Continuation Page

Special Exposure Cohort Petition —
Continuation Page — Photocopy and complete as necessary.

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Apuv 2 he va.s boskidg ektra , an _dayones __.

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Attach to Form B if necessary.

Name or Social Security Number of First Petitioner: _



CTCA: Multiple Myeloma Treatment

Cancer Treatment
Centers of America®

‘rainnung the fig aga “36 cAnee®, every ay?

Multiple Myeloma Information

MEET our cancer patients and read
their testimonials. :

es Click on’ button d testimonials...

Mo case is typical, You should not expect to experience these results.
Multiple myeloma is a type of cancer that affects the plasma of white blood cells. If
you have been diagnosed with multiple myeloma, you have a powerful ally in Cancer
Treatment Centers of America. CTCA will work with you to find a multiple myeloma
treatment that is most appropriate for you. Please keep reading to learn more about
CTCA and how we can help in your fight against multiple myeloma. To gather more
valuable information on multiple myeloma and other cancers we treat, you may aiso
want to visit our homepage: CancerCenter.com.

Information on Multiple Myeloma

Myeloma cells collect in the bone marrow and in the hard, outer part of bones.
Sometimes they collect in only one bone and form a single mass, or tumor, called a
plasmacytoma. in most cases, however, the myeloma cells collect in many bones,
forming many tumors. When this happens, the disease is called multiple myeloma.

Although multiple myeloma affects the bones, it does not begin in the bones. Multiple
myeloma originates in cells of the immune system. Multiple myeloma is different from
bone cancer, which actually begins in ceils that form the hard, outer part of the bone.
Therefore, diagnosis and treatment of multiple myeloma are different from that of bone
cancer.

Multiple Myeloma Statistics

According to the International Myeloma Foundation, there are over 13,500 new cases
of Myeloma in the U.S. each year. This represents 20% of all blood cancers, and 1%
of all types of cancer. The chances of getting multiple myeloma increase with age.

http://www.cancercenter.com/multiple-myeloma.htm

Page 1 of 2

a

2/20/2008



Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention
liIness Compensation Act National Institute for Occupational Safety and Health

. OMB Number: 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Page 7 of 7

Public Burden Statement

Public reporting burden for this collection of information is estimated to average 300 minutes per response,
including time for reviewing instructions, gathering the information needed, and completing the form. If you
have any comments regarding the burden estimate or any other aspect of this collection of information,
including suggestions for reducing this burden, send them to CDC Reports Clearance Officer, 1600 Clifton
Road, MS-E-11, Atlanta GA, 30333; ATTN:PRA 0920-0639. Do nat send the completed petition form to this
address. Completed petitions are to be submitted to NIOSH at the address provided in these instructions.
Persons are not required to respond to the information collected on this form unless it displays a currently
valid OMB number.

Privacy Act Advisement

In accordance with the Privacy Act of 1974, as amended (6 U.S.C. § 552a), you are hereby notified of the
following:

The Energy Employees Occupational Iliness Compensation Program Act (42 U.S.C. §§ 7384-7385)
(EEOICPA) authorizes the President to designate additional classes of employees to be included in the
Special Exposure Cohort (SEC). EEOICPA authorizes HHS to implement its responsibilities with the
assistance of the National Institute for Occupational Safety (NIOSH), an Institute of the Centers for Disease
Control and Prevention. Information obtained by NIOSH in connection with petitions for including additional
classes of employees in the SEC will be used to evaluate the petition and report findings to the Advisory
Board on Radiation and Worker Health and HHS.

Records containing identifiable information become part of an existing NIOSH system of records under the
Privacy Act, 09-20-147 “Occupational Health Epidemiological Studies and EEOICPA Program Records.
HHS/CDC/NIOSH." These records are treated in a confidential manner, unless otherwise compelled by law.
Disclosures that NIOSH may need to make for the processing of your petition or other purposes are listed
below.

NIOSH may need to disclose personal identifying information to: (a) the Department of Energy, other federal
agencies, other government or private entities and to private sector employers to permit these entities to
retrieve records required by NIOSH; (b) identified witnesses as designated by NIOSH so that these
individuals can provide information to assist with the evaluation of SEC petitions; (c) contractors assisting
NIOSH; (d) collaborating researchers, under certain limited circumstances to conduct further investigations;
(e) Federal, state and local agencies for law enforcement purposes; and (f) a Member of Congress or a
Congressional staff member in response to a verified inquiry.

This notice applies to all forms and informational requests that you may receive from NIOSH in connection
with the evaluation of an SEC petition.

Use of the NIOSH petition forms (A and B) is voluntary but your provision of information required by these
forms is mandatory for the consideration of a petition, as specified under 42 CFR Part 83. Petitions that fail to
provide required information may not be considered by HHS.

Name or Social Security Number of First Petitioner: __



pneeee—————————————————— aa,

Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupationay 8-25-08 A11:25 IN Centers for Disease Control and Prevention
illness Compensation Act National Institute for Occupational Safety and Health

| OMB Number: 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Page 1 of 7

Use of this form and disclosure of Social Security Number are voluntary. Failure to use this form or disclose
this number will not result in the denial of any right, benefit, or privilege to which you may be entitled.

General Instructions on Completing this Form (complete instructions are available in a separate packet):
Except for signatures, please PRINT ail information clearly and neatly on the form.

Please read each of Parts A— G in this form and complete the parts appropriate to you. If there is more
than one petitioner, then each petitioner should complete those sections of parts A—C of the form that apply
to them. Additional copies of the first two pages of this form are provided at the end of the form for this pur-
pose. A maximum of three petitioners is allowed.

If you need more space to provide additional information, use the continuation page provided at the end of
the form and attach the completed continuation page(s) to Form B.

If you have questions about the use of this form, please call the following NIOSH toll-free phone number and
request to speak to someone in the Office of Compensation Analysis and Support about an SEC petition:
1-800-356-4674.

QA Labor Organization, StartatD on Page 3

Ifyou An Energy Employee (current or former), StartatC on Page2
are: A Survivor (of a former Energy Employee), StartatB on Page 2
OA Representative (of a current or former Energy Employee), StartatA on Page 1

A Representative Information — Complete Section A if you are authorized by an Employee or
Survivor(s) to petition on behalf of a class.

A. Are you a contact person for an organization? @ Yes (Go to A.2) Q No (Go to A.3)

AZ Orpanization Information:

Name-ot Crgarizaton

AS

Mr/Mrs./Ms. First Name Middle Initial Last Name
A4 Address:

Street Apt # P.O. Box

City State Sp Code
~

AS Telephone Number: ¢ » :
A6 Email Address:

AZ @ Check the box at left to indicate you have attached to the back of this fo
petition by the survivor(s) or employee(s) indicated in Parts B or C of this for

ritten authorization to
An authorization

~

If you are representing a Survivor, go to Part B; if you are representing an Employee, go to Part C.
’ Z

Name or Social Security Number of First Petitioner: __



to

Ses ere

MOUNT ST. MARY’S HOSPITAL OF NIAGARA FALLS
5300 Military Road
Lewiston, New York 14092-1997
716-297-4800

CONSULTATION REPORT

Name:

Address:

City: Date: 06/11/94
DOB: 11/27/33

Insurance: Aetna, Policy | , patient name thru Union Carbide

Consulting Physician: Norman O. Fiorica, M.D.

Attending Physician: Frank A. Ferraro, M.D.

REASON FOR CONSULTATION: Diffuse interstitial--alveolar infiltrate, fever and mildly
immunocompromised host.

HISTORY OF PRESENT ILLNESS: This 60 year-old was admitted on 6/9/94 with
a history of temperature to 101.2°. The patient noted a cough productive of small amounts
of yellow sputum. In addition, one blood culture from 6/6/94 had grown Staph. coag.
negative organism in one culture medium. A chest x-ray from 6/9/94 revealed diffuse lung
process with left-sided predominance. CT of chest was performed on 6/10/94 which revealed
diffuse pulmonary abnormality, left more than right with interstitial alveolar infiltrates,
predominantly alveolar. No pleural fluid was identified. There was no significant mediastinal
lymphadenopathy. CBC on 6/9/94 revealed white blood count of 4.3 thousand with 74 segs,
2 bands, and 3 eosinophils. Repeat CBC on 6/11/94 revealed white blood count 5,000 with
63 segs, 2 bands, and 11 eosinophils. Hemoglobin 9.1, hematocrit 28, platelet count
225,000.

The patient has had only mild history of tobacco abuse. He states that he smoked one pack
of cigarettes daily for 20 years but quit smoking in 1968. He was a computer operator with
Union Carbide, He worked in an office inside the plant which was quite dusty for a two year ,
period of time. He then was transferred to Tennessee where he remained a computer
operator. He retired from Union Carbide in 1986. He then work in a pencil factory for a short

time.

He has no pets. He does not raise birds. He does not operate a farm. He has no exposure
to silos. He has not purchased any new furniture in his home during the past six months.

He does have a cough productive of small amounts of yellow sputum. He is mildly dyspneic.

PAST MEDICAL HISTORY: The patient has had history of Waldenstrom’s macroglobulinemia.
He was hospitalization from 4/6-9/94. Medical problems at that time included dehydration,
oral candidiasis, pancytopenia secondary to chemcthzrapy, coagulopathy secondary to

Waldenstrom’s macroglobulinemia, and a transfusion reaction associated with hemolysis. Free |
hemoglobin was present in urine on 4/8/94. Coagulation profile on 4/6/94 had revealed
protime 16/11 seconds with PTT 44 seconds, fibrinogen 163. Bone marrow examination in

CONSULTATION REPORT 5
ORIGINAL ;



spent his entire career in the Carbon Products division. Prior to July 1, 1965 he appears
to have worked in clerical positions, e.g., Senior Clerk. Starting on July 1, 1965 and until
he retired he held a variety of positions in the Information Technology group starting as a
Program Analyst until his final position as Staff Analyst. During this time he worked in:

® Niagara Falls, NY: * 1959.

© Clarksburg, WV: 1959 -._., -., 1960

¢ Columbia , TN: “1960 -—__.. --, 1965

« Niagara Falls, NY: . im , 1984

* Clarksville, TN: ~ ~  * 1984—-; , 1986.

If you have any further questions, please call the Retiree Service Center at (800) 334-
0661.

Sincerely,

Gita TE.

Andrew Flood
Authorized Representative of Union Carbide Corporation



Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention
Iliness Compensation Act National Institute for Occupational Safety and Health

OMB Number: 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Page 6 of 7

F.3. Q IWehave attached a report from a health physicist or other individual with expertise in
tadiation dose reconstruction documenting the limitations of existing DOE or AWE records on
radiation exposures at the facility, as relevant to the petition. The report specifies the basis for
believing these documented limitations might prevent the completion of dose reconstructions for
members of the class under 42 CFR Part 82 and related NIOSH technical implementation

guidelines.
(Attach report to the back of the petition form.)

F.4. O INWehave attached a scientific or technical report, issued by a government agency of the
Executive Branch of Government or the General Accounting Office, the Nuclear Regulatory
Commission, or the Defense Nuclear Facilities Safety Board, or published in a peer-reviewed
journal, that identifies dosimetry and related information that are unavailable (due to either a lack
of monitoring or the destruction or loss of records) for estimating the radiation doses of
employees covered by the petition.

(Attach report to the back of the petition form.)
Go to Part G.
on(s) Submitting this Petition — Complete Section G.

Signature of

All Petitioners should-sian and date the petition. A maximum of three persons ma the petition.
£ fab LO€.
¢v signature Dati

#
Signature Date
Signature Date
Notice: Any person who knowingly makes any false statement, misrepresentation, concealment of

fact or any other act of fraud to obtain compensation as provided under EEOICPA or who
knowingly accepts compensation to which that person is not entitled is subject to civil or
administrative remedies as well as felony criminal prosecution and may, under appropriate
criminal provisions, be punished by a fine or imprisonment or both. | affirm that the information
provided on this form is accurate and true.

Send this form to: SEC Petition
Office of Compensation Analysis and Support
NIOSH
4676 Columbia Parkway, MS-C-47
Cincinnati, OH 45226

_— —_ — —
If there are additional petitioners, they must complete the Appendix Forms for additional petitioners.
The Appendix forms are located at the end of this document.

Name or Social Security Number of First Petitioner:



Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention

{llness Compensation Act National Institute for Occupational Safety and Health

OMB Number: 0920-0639 Expires: 05/31/2007

Special Exposure Cohort Petition — Form B Page 4 of 7
Proposed Definition of Employee Class Covered by Petition — Complete Section E.

E.1 Name of DOE or AWE Facility: Lhe.

E.2 Locations at the Facility relevant to this petition:

a
Building He // an a ¥ 30
a)

E.3 List job titles and/or job duties of employees included in the class. In addition, you can list by
name any individuals other than petitioners identified on this form who you believe should be
included in this class: >

Com paper progta paeist Sy, stem. An aye!

E.4 Employment Dates relevant to this petition:
stat {708 end 27H
stat L277 end LLL
Start End

Eé Is the petition based on one or more unmonitored, unrecorded, or inadequately monitored or
recorded exposure incidents?: Yes Q No
If yes, provide the date(s) of the incident(s) and a complete description (attach additional pages
as necessary):

oe — — ~~
Go to Part F.
Name or Social Security Number of First Petitioner: _



R INSTITUTE

Home> PatientCare> Types ofCancer> Hematology> Multiple Myeloma

Multiple Myeloma

Overview

Multiple mycloma is the name given to a group of diseases
called plasma cell neoplasms. Plasma cells are made by white
blood cells called lymphocytes. The plasma cells make
antibodies, the parts of the blood that fight infection and
toxins). When plasma cells become cancerous, they may make
too many antibodies.

os Was -
‘Maltiple myeloma is more common in African-Americans then . ; Kely +0 havr
Caucasians in people over age 45, and in people who have , 50 he wes Less hs a fe
teen expostdtoradiation and industrial chemicals, =, (i asvelly Contaated Mal ty
Incidence

The American Cancer Society estimates that more than 19,900
new cases of multiple myeloma will be diagnosed in 2008.

Signs & Symptoms

Early symptoms may include swollen lymph nodes, liver and
spleen; bone pain; and easy bruising.

Screening & Diagnosis

No screening tests are available. Blood tests, lymph node
biopsy, CT and MRI scans, and bone marrow biopsy are used
to diagnose this cancer.

Treatment

Chemotherapy is the main treatment option, although some
patients may receive immunotherapy or radiation therapy as
well. In some cases, blood and marrow transplantation may be
an option.

© Copyright 2008, Roswell Park Cancer Institute,

http:/Awww.roswellpark.org/Site/Patient_Care/Types_of_Cancer/Hematology_Center/Mult... 6/30/2008



particles given off by radioactive materials such as alpha particles, beta
rays, and protons. These forms of radiation have different energy levels
and can penetrate cells to different extents, but all are capable of causing

ionization.
People may be exposed to 3 main types of ionizing radiation:

» Natural background radiation comes from cosmic rays from our
solar system and radioactive elements normally present in the soil.
This is the major contributor to worldwide radiation exposure.

» Non-medical synthetic radiation occurs as a result of above
ground nuclear weapons testing that took place before 1962 as well
as occupational and commercial sources.

« Medical radiation comes in the form of diagnostic x-rays and other
tests, as well as from radiation therapy. Radiation therapy is
currently used to treat some types of cancer and involves dosages
many thousand times higher than those used in diagnostic x-rays.

Does lonizing Radiation Cause Cancer?

lonizing radiation has been shown to induce (cause) cancer in many
different species of animals and in almost all parts of the body. itis one of
the few scientifically proven carcinogens (cancer-causing agents in
human beings, although it appears to be a relatively weak carcinogen
compared to many chemical agents. Many years may elapse between the
radiation exposure and the appearance of the cancer.

The types of cancer that can be caused by radiation can also occur
naturally (without increased exposure to radiation), but some occur more
frequently as a result of radiation. For example, a higher percentage of
small cell lung cancers occur in uranium miners as a result of exposure to
alpha radiation (a form of highly ionizing radiation).

= > gland ang bone. marrow are. most sensitive {ora on ° the
|. Some forms of

bladder, and ovary seem to be least affecte

—>> type of cancer that arises in the bone marrow, appear to be the most
2 common radiation-induced cancers. :

Evidence that ionizing radiation causes cancer comes from studies of
atomic bomb survivors in Japan, persons exposed to large amounts of x-
rays, and from certain occupational exposures, such as workers with lung
exposure fo alpha radiation. These studies, however, generally involved
relatively high-dose exposure - greater than 10 centigray. (A centigray
(cGy) is a standard unit of radiation dose.) Therefore, the tisk estimates
for lower doses of radiation have to be estimated from the high-dose data,
and may not be accurate.

Dose-Related Radiation Effects

los @ _ fonizing radiation is probably the only carcinogen with evidence that its
on effects are related to dose exposure. The probability that cancer will result
h from radiation exposure increases as the dose increases. However, there
is no evidence to suggest that the grade (tendency to grow and spread) of
the resulting cancer is affected by the dose. In other words, higher doses
of radiation do not cause more aggressive cancers. .
AA ‘Dose Radiation Exposure

hu ner do

awn oo
ttp://www.cancer.org/docroot/PED/content/PED_1_3X_Radiation_Exposure_and_Cancer... 2/20/2008



Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention
Iliness Compensation Act National Institute for Occupational Safety and Health
OMB Number: 0920-0639 Expires: 05/31/2007

ecial Exposure Cohort Petition — Form B Page 3 of 7
Labor Organization Information — Complete Section D ONLY if you are a labor organization.

D.1_ —_ LaBer Organization Information:

Name of oraangaton

S|

D.2

D.3 Address of Petition Representative:

Street Apt # P.O. Box

City State NER Cote
D.4 Telephone Number of Petition Representative: ¢ L -

D.5 Email Address of Petition Representative:

D.6 _ Period during which labor organization represented employees coveted by this petition
(please attach documentation): Stat _ End
D.7__ Identity of other labor organizations that may represent or have represented this class of
employees (if known):
Go to Part E.

Name or Social Security Number of First Petitioner: _



Special Exposure Cohort Petition U.S. Department of Health and Human Services

under the Energy Employees Occupational Centers for Disease Control and Prevention
Iliness Compensation Act National Institute for Occupational Safety and Health

OMB Number: 0920-0639 Expires: 05/31/2007
Special Exposure Cohort Petition — Form B Page 2 of 7

Survivor Information — Complete Section B if you are a Survivor or representing a Survivor.

Bl Name of Survivor: dou
First Name Middle initial Last Name
B.2 Social Security Number of Survivor:
B.3 Address of Survivor: ; al
Street, , SN ca Apt # P.O. Box
a ee .
City State Zip Code

B.4. Telephone Number of Survivor; jo | DL
B.5 Email Address of Survivor:
B.6 Relationship to Employee:

Go to Part C.
Cc Employee Information — Complete Section C UNLESS you are a labor organization.
C.1 Name of Employee: — leat
First Name Middle Initial ““ Last Name

C.2. Former Name of Employee (e.g., maiden name/legal name change/other):

iir/Mrs./Ms. First Name Middle Initial Last Name
C.3 Social Security Number of Employee: = _
C.4 Address of Employee (f living):

Street Apt # P.O. Box

City State Zip Code
C.5 Telephone Number of Employee: ) :
C.6 Email Address of Employee:

C.7_ _ Emptoyment Information Related to Petition:
C.7a Employee Number (if known):

C.7b Dates of Employment: _ Start
C.7c Employer Name: 2.
C.7d Work Site Location: Tone wande , A) y.

C.7e Supervisor's Name:

Go to Part E.

Name or Social Security Number of First Petitioner:



Effective Date: Revision No. Document No. Page No.
July 14, 2006 6 (Draft) 109 of 126
Site Description

The southwest corner of the site was referred to as the Tonawanda Laboratory. This included

Buildings 10, 11, 12, 13,
made up the remainder of

14, 15, 16, 23, 34, 43, 44, 47, 52, 62, 66 and 100. The factory area
the site and included the production facilities used during the MED

project. Table A3.1 below describes the buildings on the Linde site and their current status.

Table A3.1. Descriptions of Select Linde Buildings
Building Description Current Status
A Manhattan Engineering District offices Torn down
B Administrative Torn down
1 Administrative Support Current
2 Factory Manufacturing Area Converted to laboratories;
Current
8 Old Powerhouse Pending tear down.
9 Meter and Generating Room Renovations
10 Laboratory Administration with Labs; Navy Current
Laboratory
Le Instrument Service Department, Silicon Rubber, Remodeled half the
Silicon, Dynamonitor Lab, Navy Project building in the late-1960s_
to create office.area and
\y large computer room;,
» oe Remodeled again to
v remove the computer room
_gxe%ark and addlabs upstairs
14 R&D Laboratory, Uranium Processing; High Fiux ‘In Procdss of being Torn
Tubing; Silicon Production; Experimental Down
Laboratory; Oxygen manufacturing
15 Engineering Laboratory; Cryogenic Laboratory; Renovations several times;
Garages; Krypton-85 gases used Current
16 Engineering Laboratory Renovations several times;
Current
19 Metal Fabrication Building Torn down; New
Powerhouse built where
this building was
previously
23 Guard Shack Torn down
25 Battery House. Torn down.
27 Engineering Department Current
29 Maintenance Department Torn down
30 Ceramics Building; Storage; Offices; wooden Tor Down
building with cinder blocks and dirt floor
31 Molecular Sieves; Research Laboratory; U- Pending tear down;
processing, Renovated in 1957
33 Engineering Department Torn Down.
34 ‘Molecular Sieves Laboratory Building Pending tear down.
37 Storage; High Flux Cooling Area Torn Down
38 Rare Gas Laboratory; U-processing; wooden Torn Down
building with cinder blocks and dirt floor
39 ‘Laboratory Building; wooden building with cinder Torn Down

blocks and dirt floor



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Radiation Exposure and Cancer

Radiation is the emission (sending out) of energy from any source. The
light that comes from the sun is a source of radiation, as is the heat that is
constantly coming off our bodies. When talking about radiation, however,
most people think of specific Kinds of radiation such as that produced by
radioactive materials or nuclear reactions. Most forms of radiation have
not been linked to cancer. Only high frequency radiation (ionizing radiation
and ultraviolet radiation) has been proven to cause genetic damage, which
can lead to cancer.

The hazards of exposure to some kinds of radiation were recognized
shortly after the discovery of the x-ray in 1895. Skin reactions were
observed in many people working with early x-ray generators, and by
4902 the first radiation-caused cancer was reported in a skin sore. Within
a few years, a large number of such skin cancers had been observed. The
first report of leukemia (a cancer of the bone marrow) in radiation workers
appeared in 1911. Marie Curle, the discoverer of radium, and her daughter
are believed to have died of radiation-caused leukemia. Since that time,
many studies have confirmed the cancer-causing effects of some types of
radiation.

lonizing Radiation

Radiation can generally be defined as being ionizing or non-ionizing.
lonizing radiation consists of high-energy waves that are able to penetrate
cells and can cause ionization in different parts of the cell. nization is the
development of a positive charge in a molecule (group of atoms) that is
normally neutral (without a charge). lonized molecules are unstable and
quickly undergo chemical changes. This can lead to the formation of free
radicals that can damage the molecule or other molecules around it.

One type of molecule that is sensitive to ionizing radiation is DNA, the part
of the cell that contains the genes (blueprints) for each person's
characteristics. lonizing radiation can lead to a mutation (change) in a
cell's DNA, which could contribute to cancer, or to the death of the cell. All
cells in the body can be damaged by ionizing radiation. The amount of
damage is related to the dose of radiation received by the cell. While the.
process of cellular change from radiation takes only a fraction of a second, ,
‘other changes such as the beginning of cancer may take years to develop.

Types of ionizing radiation include x-rays, gamma rays, cosmic rays, and

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