23272 Federal Register / Vol. 75, No. 84 / Monday, May 3, 2010 / Notices 

EXHIBIT 1—ESTIMATED ANNUALIZED BURDEN HOURS

Form name Number of 

organizations 

Number of 

responses per 

responding 

organization 

Hours per 

response 

Total burden 

hours 

Semi-structured interviews .............................................................. 9 1 1 9 

Cognitive interviews ......................................................................... 30 1 1 30 

Total .......................................................................................... 39 NA NA 39 

EXHIBIT 2—ESTIMATED ANNUALIZED COST BURDEN

Form name Number of 

respondents 

Total burden 

hours 

Average hourly 

wage rate * Total cost burden 

Semi-structured interviews .............................................................. 9 9 $42.67 $384 

Cognitive interviews ......................................................................... 30 30 42.67 1,280 

Total .......................................................................................... 39 39 NA 1,664 

* Based upon the mean of the average wages, National Compensation Survey: Occupational wages in the United States 2008, ‘‘U.S. Department of Labor, Bureau of Labor Statistics.’’ 

Estimated Annual Costs to the Federal 

Government 

Exhibit 3 shows the estimated total 

and annualized cost to the Federal 

government to conduct this redesign of 

the Adverse Event Reporting 

Questionnaire and associated sample 

design. Since this project will last for 

one year the total and annualized costs 

are the same. The total cost is estimated 

to be $120,000. 

EXHIBIT 3—ESTIMATED TOTAL AND ANNUALIZED COST

Cost component Total cost Annualized cost 

Project Development ....................................................................................................................................... $24,000 $24,000 

Data Collection Activities ................................................................................................................................. 46,000 46,000 

Data Processing and Analysis ......................................................................................................................... 26,000 26,000 

Project Management ........................................................................................................................................ 24,000 24,000 

Total .......................................................................................................................................................... 120,000 120,000 

Request for Comments 

In accordance with the above-cited 

Paperwork Reduction Act legislation, 

comments on AHRQ’s information 

collection are requested with regard to 

any of the following: (a) Whether the 

proposed collection of information is 

necessary for the proper performance of 

AHRQ healthcare research and 

healthcare information dissemination 

functions, including whether the 

information will have practical utility; 

(b) the accuracy of AHRQ’s estimate of 

burden (including hours and costs) of 

the proposed collection(s) of 

information; (c) ways to enhance the 

quality, utility, and clarity of the 

information to be collected; and (d) 

ways to minimize the burden of the 

collection of information upon the 

respondents, including the use of 

automated collection techniques or 

other forms of in formation technology. 

Comments submitted in response to 

this notice will be summarized and 

included in the Agency’s subsequent 

request for OMB approval of the 

proposed information collection. All 

comments will become a matter of 

public record. 

Dated: April 20, 2010. 

Carolyn M. Clancy, 

Director. 

[FR Doc. 2010–10195 Filed 4–30–10; 8:45 am] 

BILLING CODE 4160–90–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 207 to achieve expeditious 

commercialization of results of 

federally-funded research and 

development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

ADDRESSES: Licensing information and 

copies of the U.S. patent applications 

listed below may be obtained by writing 

to the indicated licensing contact at the 

Office of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301/ 

496–7057; fax: 301/402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

Retroviral Vectors for Selective 

Reversible Immortalization of 

Stimulus-responding Primary Cells 

Description of Invention: Researchers 

at the National Cancer InstituteFrederick, NIH, have developed a novel 

set of retroviral vectors and producer 

cell lines useful for selective reversible 

immortalization of primary cells (i.e. 

lymphocytes) that respond to a 

stimulus, such as a viral antigen (e.g. 


erowe on DSK5CLS3C1PROD with NOTICES
Federal Register / Vol. 75, No. 84 / Monday, May 3, 2010 / Notices 23273 

HIV toxoids), a tumor antigen, or a 

growth factor. 

Derived from the murine leukemia 

virus (MuLV), these retroviral vectors 

will only infect dividing cells. 

Therefore, only primary cells activated 

by the stimulus will be infected and 

immortalized, thereby creating an 

‘‘antigen-specific trap.’’ 

The primary cells to be immortalized 

can be in targeted tissue or in stimulated 

ex vivo culture. The transduced cells 

can be expanded to large numbers 

without differentiating, and returned to 

the primary cell stage by removal of the 

introduced genes using a vector excision 

strategy. 

Applications 

• Isolation/replication of normally 

short-lived primary cells that respond to 

a stimulus. 

• Immortalization of antigen-specific 

T cells for vaccine development or 

adoptive transfer immunotherapy. 

• Production of primary cell lines for 

large-scale production of cell-secreted 

factors, cytokines, and other molecules. 

Advantages 

• System acts as an anti-senescence 

treatment: Cells that are normally shortlived can be kept in culture for years. 

• Vectors with different markers are 

available to identify transduced cells 

and for cell selection. 

• Excision allows for gene/marker 

removal. 

• The MuLV-based system only 

infects dividing (e.g. activated) cells 

Inventors: Eugene V. Barsov and 

David E. Ott (NCI). 

Relevant Publications 

1. E Barsov et al. Capture of antigenspecific T lymphocytes from human 

blood by selective immortalization 

to establish long-term T-cell lines 

maintaining primary cell 

characteristics. Immunol Lett. 2006 

May 15;105(1):26–37. [PubMed: 

16442639] 

2. H Andersen et al. Transduction with 

human telomerase reverse 

transcriptase immortalizes a rhesus 

macaque CD8+ T cell clone with 

maintenance of surface marker 

phenotype and function. AIDS Res 

Hum Retroviruses 2007 

Mar;23(3):456–465. [PubMed: 

17411379] 

Patent Status: HHS Reference No. E– 

140–2010/0—Research Tool. Patent 

protection is not being pursued for this 

technology. 

Licensing Status: Available for 

biological materials licensing only. 

Licensing Contact: Patrick P. McCue, 

PhD; 301–435–5560; 

mccuepat@mail.nih.gov. 

Collaborative Research Opportunity: 

The Center for Cancer Research, AIDS 

and Cancer Virus Program, is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate, or 

commercialize this technology. Please 

contact John Hewes, PhD at 301–435– 

3131 or hewesj@mail.nih.gov. for more 

information. 

A Method of Measuring Ultraviolet A 

(UVA) Protection in Sunscreen 

Products 

Description of Invention: There are 

different types of ultraviolet (UV) rays 

in sunlight. UVB radiation causes 

redness (erythema) or sunburn. While 

UVA radiation, which absorbs deep into 

the skin, causes more long-term effects 

such as wrinkles, skin aging and skin 

cancer. 

Effective sunscreens are expected to 

block both UVA and UVB radiation. The 

Sun Protection Factor (SPF) label found 

on all over-the-counter sunscreen 

products is a better measure for UVB 

protection than UVA protection. 

Currently, there is no standard in vivo 

test to determine the amount of UVA 

protection in sunscreen products, 

despite the fact that many products are 

advertised as effectively blocking both 

UVA and UVB radiation. 

This invention describes sets of genes 

useful for measuring UVA exposure in 

human skin and assessing sunscreen 

products for their ability to block UVA 

radiation. 

Application: A test for measuring 

UVA protection provided by 

sunscreens. 

Development Status: Early stage. 

Market: According to a report by the 

Global Industry Analysts, Inc., the sun 

care market is projected to reach $5.6 

billion by the year 2015. 

Inventors: Atsushi Terunuma and 

Jonathan C. Vogel (NCI). 

Related Publication: In preparation. 

Patent Status: U.S. Provisional 

Application No. 61/309,179 filed 01 Mar 

2010 (HHS Reference No. E–097–2010/ 

0–US–01). 

Licensing Status: Available for 

licensing. 

Licensing Contact: Charlene Sydnor, 

PhD; 301–435–4689; 

sydnorc@mail.nih.gov. 

Collaborative Research Opportunity: 

The Center for Cancer Research, 

Dermatology Branch, is seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate, or 

commercialize this technology. Please 

contact John Hewes, PhD at 301–435– 

3131 or hewesj@mail.nih.gov for more 

information. 

Laser Scanning Microscopy for Three 

Dimensional Motion Tracking for 

Volumetric Data 

Description of Invention: The 

technology offered for licensing and for 

further development is in the field of 

volumetric tissue scanning microscopy. 

More specifically, the invention 

provides for a device, system and 

methods that can acquire and analyze 

volumetric data from a high-speed laserscanning microscope and compute 

motion of the sample under the 

microscope in three dimensions. This 

computed motion is used to adjust 

position of the sample in real time to 

maintain field of view and relative 

location. This motion compensation 

scheme can be used to collect micronscale information over time, which can 

be important in a number of research or 

medical device applications. 

Applications 

• Biomedical research involving in 

vivo microscopy. 

• Real time tracking of cells or 

cellular structures. 

• Tracking tissue during various 

physiological perturbations and 

observation of dynamic physiological 

processes. Physiological perturbations 

include metabolic substrates, drug 

delivery and anoxia. 

• Potential applications in molecular 

diagnostic imaging. 

• Potential applications in medical 

procedures such as biopsy and 

microsurgery where information has to 

be collected from a specific microscope 

location over a period of time. 

Advantages 

• Improved analytical capabilities for 

biological processes. 

• Improved capabilities of accurately 

examining and studying physiological 

perturbations. 

• Potential improvement in medical 

procedures such as biopsy. 

• May readily be adaptable to 

commercial microscopes. 

Development Status: The invention is 

fully developed. Further work needs to 

be done in the following areas: 

• Adaptation to different types of 

microscopes. 

• Further demonstration of utility of 

in-vivo imaging. 

Inventors: James L. Schroeder 

(NHLBI) et al. 

Related Publication: Schroeder JL, 

Luger-Hamer M, Pursley R, Pohida T, 

Chefd’Hotel C, Kellman P, Balaban RS. 

Short communication: Subcellular 

motion compensation for minimally 

invasive microscopy, in vivo: evidence 

for oxygen gradients in resting muscle. 


erowe on DSK5CLS3C1PROD with NOTICES
23274 Federal Register / Vol. 75, No. 84 / Monday, May 3, 2010 / Notices 

Circ Res. 2010 Apr 2;106(6):1129–1133. 

[PubMed: 20167928]. 

Patent Status: U.S. Provisional 

Application No. 61/245,586 filed 24 Sep 

2009 (HHS Reference No. E–290–2009/ 

0–US–01). 

Licensing Status: Available for 

licensing. 

Licensing Contacts: Uri Reichman, 

PhD, MBA; 301–435–4616; 

UR7a@nih.gov, or Michael Shmilovich, 

Esq.; 301–435–5019; 

ShmilovichM@mail.nih.gov. 

Collaborative Research Opportunity: 

The National Heart, Lung, and Blood 

Institute, Laboratory of Cardiac 

Energetics, is seeking statements of 

capability or interest from parties 

interested in collaborative research to 

further develop, evaluate, or 

commercialize automatic 3D volumetric 

motion tracking systems for use during 

in vivo microscopy. Please contact 

Denise Crooks, PhD at 301–435–0103 or 

crooksd@nhlbi.nih.gov for more 

information. 

Dated: April 26, 2010. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2010–10264 Filed 4–30–10; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Office of the Secretary 

[Docket No. DHS–2010–0031] 

Privacy Act of 1974; Department of 

Homeland Security United States 

Immigration Customs and 

Enforcement—011 Immigration and 

Enforcement Operational Records 

System of Records 

AGENCY: Privacy Office, DHS. 

ACTION: Notice of amendment of Privacy 

Act system of records. 

SUMMARY: In accordance with the 

Privacy Act of 1974 the Department of 

Homeland Security U.S. Immigration 

and Customs Enforcement is updating 

an existing system of records titled, 

Department of Homeland Security/U.S. 

Immigration and Customs 

Enforcement—011 Immigration and 

Enforcement Operational Records 

System of Records (ENFORCE). With the 

publication of this updated system of 

records, a new routine use has been 

proposed. The routine use would 

support the deployment of the ICE 

Online Detainee Locator System, which 

provides a searchable online database to 

help members of the public locate 

detainees in ICE custody. This routine 

use would also support the sharing of 

information about ICE detainees for the 

purpose of allowing family members 

and other individuals to deposit money 

in detainee accounts for telephone and 

commissary services within a detention 

facility. A Privacy Impact Assessment 

that describes the Online Detainee 

Locator System is being published 

concurrently with this notice. It can be 

found on the DHS Web site at http:// 

www.dhs.gov/privacy. This updated 

system will continue to be included in 

the Department of Homeland Security’s 

inventory of record systems. 

DATES: Submit comments on or before 

June 2, 2010. This amended system will 

be effective June 2, 2010. 

ADDRESSES: You may submit comments, 

identified by docket number DHS– 

2010–0031 by one of the following 

methods: 

• Federal e-Rulemaking Portal: 

http://www.regulations.gov. Follow the 

instructions for submitting comments. 

• Fax: 703–483–2999. 

• Mail: Mary Ellen Callahan, Chief 

Privacy Officer, Privacy Office, 

Department of Homeland Security, 

Washington, DC 20528. 

• Instructions: All submissions 

received must include the agency name 

and docket number for this rulemaking. 

All comments received will be posted 

without change to http:// 

www.regulations.gov, including any 

personal information provided. 

• Docket: For access to the docket to 

read background documents or 

comments received go to http:// 

www.regulations.gov. 

FOR FURTHER INFORMATION CONTACT: Lyn 

Rahilly (703–732–3300), Privacy Officer, 

U.S. Immigration and Customs 

Enforcement, 500 12th Street, SW., Mail 

Stop 5004, Washington, DC 20536; or 

Mary Ellen Callahan (703–235–0780), 

Chief Privacy Officer, Privacy Office, 

U.S. Department of Homeland Security, 

Washington, DC 20528. 

SUPPLEMENTARY INFORMATION: 

I. Background 

ICE is proposing a new routine use to 

permit sharing of limited information 

about current and former persons in ICE 

custody through the Online Detainee 

Locator System (ODLS). ODLS is a 

publicly accessible, Web-based system 

owned by U.S. Immigration and 

Customs Enforcement (ICE) Office of 

Detention and Removal Operations 

(DRO). 

DRO is responsible for promoting 

public safety and national security by 

arresting, detaining, and removing 

persons from the United States in 

accordance with the Immigration and 

Nationality Act. ICE developed ODLS as 

a service to the public, especially family 

members and legal representatives, to 

help locate individuals arrested for 

administrative immigration violations 

and who are in or have recently left ICE 

custody (‘‘detainees’’). Currently, 

members of the public must contact a 

DRO field office by phone to determine 

the location of a detainee. With the 

deployment of this automated system, 

the public will be able to locate 

detainees more quickly and efficiently 

through an online query. The system 

will ultimately be available in several 

languages to help users whose native 

language is not English. 

ODLS is a Web-based system that is 

accessible from an Internet browser and 

may be used by any member of the 

public. ODLS is scheduled to deploy in 

June 2010, and will be accessible by 

visiting ICE’s public Web site (http:// 

www.ice.gov/locator). Persons using 

ODLS do not need to set up an account 

or get special permission to use the 

system. ODLS provides two ways to 

search for a detainee: (1) Perform a 

query using an Alien Registration 

Number (A–Number) and country of 

birth; or (2) perform a query using a full 

name and country of birth. After 

receiving the query entered by the user, 

ODLS searches for a match among 

current ICE detainees and detainees 

who have been booked out of ICE 

custody (regardless of the reason) within 

the last 60 days. All records that match 

the user’s query are returned to the user 

in a list of one or more search results. 

ODLS only performs exact-match 

searches. This means that the search 

query entered by the user (specifically, 

the name or A–Number) must exactly 

match the information in a detention 

record in order for the record to be 

identified as a match and included in 

the ODLS search results. For example, a 

search for ‘‘Robert Smith’’ will not return 

a detention record for ‘‘Robert Smyth’’ or 

‘‘Bob Smith.’’ When conducting an A– 

Number search, ODLS users will see a 

maximum of one record in the results 

because A–Numbers are assigned to 

individuals uniquely. When conducting 

a name-based search, however, ODLS 

users may see multiple records in the 

results if several detainees share the 

same name and country of birth. Users 

may use the year of birth provided in 

the results to distinguish among 

detainees with the same name. 

ODLS only contains information 

about individuals who are currently in 

ICE custody or were previously detained 

by ICE within the past 60 days. If a 

search is performed for detainees who 


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