Verification of the NIOSH-IREP 

Computer Code 

Version 5.5.3 

July 2009 

SENES Oak Ridge, Inc. ● 102 Donner Drive ● Oak Ridge, Tennessee ● 37830 ● Tel: (865) 483-6111 
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TABLE OF CONTENTS 

1. Introduction..................................................................................................................1

2. Overview of the Methodology.....................................................................................3 

3. Findings of the Verification Exercises.........................................................................6 

4. Verification of Consistency between the Source Code and Its Documentation ..........9 

5. Deterministic Verification of Mid and Upper Values of ERR and PC .....................11 

5.1. Testing Primary Equations for Each Cancer Type ........................................14 

5.2. Testing Equations for Minimum Latency Period...........................................17 

5.3. Testing Implementation of the Radiation Effectiveness Factor.....................19 

5.4. Testing Implementation of the Dose and Dose Rate Effectiveness Factor....21 

5.5. Testing the Effect of Ethnic Origin on Risk of Skin Cancer .........................23 

5.6. Testing the Effect of Smoking on the Risk of Lung Cancer for non-Radon 

Exposures.......................................................................................................25 

5.7. Testing the Effect of Smoking on the Risk of Lung Cancer for Radon 

Exposures.......................................................................................................26 

5.8. Testing the Implementation of Multiple Exposures Algorithms ....................... 

6. Verification of Monte-Carlo Uncertainty Propagation Algorithms...........................28 

7. Summary and Conclusions ........................................................................................32 

8. References..................................................................................................................35 

APPENDICES

Appendix A Effect of the Findings on PC results produced by NIOSH-IREP 

Appendix B General Verification Calculations 

Appendix C Verification of the Implementation of the Minimum Latency Period for 

Leukemia, Thyroid, and Solid Tumor Cancers 

Appendix D Verification of the Implementation of the Radiation Effectiveness Factors 

(REF) for Exposure to Alpha Radiation, Neutrons, and Low Energy 

Photons and Beta Particles 

Appendix E Verification of the Implementation of the DDREF for Low Dose and High 

Dose Acute and Chronic Exposures 

Appendix F Effect of Ethnic Origin on the ERR per Unit Dose for Skin Cancer 

Appendix G Effect of Cigarette Smoking on the Risk of Lung Cancer (non-Radon 

Exposures) 

Appendix H Effect of Cigarette Smoking on the Risk of Lung Cancer from Radon 

Exposures 

Appendix I Verification of the Implementation of Multiple Exposures Algorithms 

Appendix J Results of Testing the Monte Carlo Uncertainty Propagation Algorithms 
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1. Introduction 

On May 2, 2002, the Department of Health and Human Services published its 

final rule on the guidelines to be used by the Department of Labor (DOL) to determine 

the probability that a cancer included in a claim under the Energy Employees’ 

Occupational Illness Compensation Program Act of 2000 (EEOICPA; U.S. DHHS 2002) 

was caused by the worker’s exposure to radiation during nuclear weapons production. 

DOL makes such a determination by estimating the "probability of causation" for each 

claim using a radiation dose reconstruction completed by the National Institute of 

Occupational Safety and Health (NIOSH). 

To determine probability of causation (PC) for a cancer claim under EEOICPA, 

DOL uses the NIOSH version of the Interactive Radio-Epidemiological Program (IREP), 

referred to as NIOSH-IREP, a computer software application developed in collaboration 

with the National Cancer Institute. This computer software is a science-based tool that 

allows DOL to determine the probability that a cancer was caused by a person's radiation 

dose incurred during employment at facilities that support the development, production 

and testing of nuclear weapons. NIOSH-IREP is tailored to the risks and radiation 

exposures characteristic of nuclear weapons employees. The actual outcome of a claim 

depends on a number of important factors such as estimates of the radiation doses from 

complex exposure histories, the various types of radiation, the age at exposure, gender, 

the type of cancer and the age at which the cancer was diagnosed. 

The methodology for estimation of risk and probability of causation used by 

NIOSH-IREP was initially developed by a working group of the National Cancer 

Institute (NCI) and the Centers for Disease Control and Prevention (CDC). The 

methodology was reviewed internally by NCI and externally by an NCI advisory 

committee. An additional formal external review was performed by a committee of the 

National Academy of Sciences (NAS/NRC 2000). The methodology was further 

reviewed and expanded by the NIOSH Office of Compensation Analysis and Support 

(NIOSH-OCAS) prior to the adoption of NIOSH-IREP as the main computational tool 

for estimating PC for individual cancer claims in the EEOICPA compensation program. 
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The NIOSH-IREP software was adopted and released by NIOSH for use in the 

EEOICPA compensation program in April 2002. This software has been tested 

numerous times, by its developers (SENES Oak Ridge, Inc.), by NIOSH–OCAS staff 

(before and after its official release), and by DOL staff who use the code on a daily basis. 

Comments about the operation of the software have also been received from members of 

the public who have used NIOSH-IREP. The issues found during testing and the 

comments received from different users of the code have led to a number of changes to 

the NIOSH-IREP software. A list of software updates resulting from the comments and 

from issues found during different phases of testing is available on-line at 

(www.niosh-irep.com/irep_niosh/update.asp). 

This report presents the results of a formal verification effort1 organized to ensure 

that the most current version of NIOSH-IREP software (version 5.5.3) calculates risk and 

probability of causation (PC) according to the methodology agreed upon by NCI and 

NIOSH. It is important to note that this effort has not attempted to “validate” or question 

the models and procedures developed by NCI and NIOSH; this effort “verifies” that each 

part of the NIOSH-IREP code operates according to its intended use described in its 

technical documentation (NIOSH 2002; Land et al. 2003; Kocher et al. 2008). 

An overview of the methodology used to verify that NIOSH-IREP is operating as 

intended is presented in Section 2. A discussion of the findings, including 

inconsistencies that were identified, is presented in Section 3. Detailed descriptions of 

the three phases of testing are given in Sections 4, 5, and 6. Section 7 contains the 

summary and conclusions. Results of the detailed testing of NIOSH-IREP are presented 

in the appendices. 

 

1

 The term “verification” refers to the process of determining that the implementation of the methodology 

in the computer software accurately represents the developer’s conceptual description of the models and 

their solution (in this case, the risk and PC models that describe the relationship between exposure to 

ionizing radiation and incidence of cancer) (LANL 2004). 
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2. Overview of the Methodology 

The verification efforts described in this report refer to NIOSH-IREP v.5.5.3, the 

version of the computer code that is currently used by DOL and NIOSH. This 

verification process was performed by individuals of SENES Oak Ridge, Inc. who were 

not involved in the initial development of the code. The purpose of the verification effort 

is to ensure that NIOSH-IREP v.5.5.3 operates within the parameters, equations and 

assumptions of the risk assessment methodology described in the formal documentation 

of the code (NIOSH 2002; Land et al. 2003; Kocher et al. 2008). 

The NIOSH-IREP source code uses the Analytica® programming language and is 

accessed via an Internet-based user interface. NIOSH-IREP estimates the probability of 

causation (PC) as PC = ERR/(1+ ERR) where ERR is the excess relative risk of cancer 

due to previous exposures to radiation. The excess relative risk (ERR) depends on 

personal information about the exposed individual such as gender, race2

, smoking 

history3, and the age at which the cancer was diagnosed. ERR depends also on the 

exposure history of the exposed individual (i.e., age at exposure, magnitude of radiation 

doses received, the rate at which doses were delivered and the radiation types involved). 

The exposure history and personal information are used as input for the risk model 

associated with the diagnosed cancer (Land et al. 2003; Kocher et al. 2008). 

NIOSH-IREP uses Monte-Carlo methods to propagate the uncertainties associated 

with the parameter values of the risk model and with the parameters of the exposure 

history. The ERR and PC are estimated as probability distribution functions described 

numerically by the collection of the ERR and PC values obtained from each Monte-Carlo 

iteration. 

For adjudication of claims in the EEOICPA program, the 99th percentile of PC is 

compared to a value of 50%. The goal of the verification process is to ensure that the 

entire probability distributions of ERR and PC, and especially the 99th percentile of ERR 

and PC, are correctly estimated by the NIOSH-IREP v.5.5.3 computer code. This goal 

was accomplished by verifying that the equations and numerical data used to calculate 

2

 For skin cancer claims only. 

3

 For lung cancer claims only. 
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n. 

 

ERR and PC are correctly implemented in the NIOSH-IREP code, and by comparing the 

ERR and PC produced by NIOSH-IREP with ERR and PC calculated based on the same 

risk models encoded in a programming environment independent from Analytica®. 

The following steps were taken to test and verify the NIOSH-IREP source code: 

1. The mathematical equations of the risk models and any associated numerical 

data implemented in the NIOSH-IREP source code were compared with the 

equations described in the documentation of NIOSH-IREP. 

2. The mathematical equations and numerical data of the risk models used by 

NIOSH-IREP were independently programmed using Microsoft Excel® and 

Crystal Ball®4

, creating a scaled-down version of the code5 that could be 

used for verificatio

2a. Values of the risk model parameters closest to the 50th (midpoint) and 

99th (upper) percentiles of the ERR and PC produced by NIOSH-IREP 

were used as input for deterministic calculations in MS Excel, for all 

cancer types and various selected exposure scenarios. Estimates of 

the midpoint and upper bound results calculated deterministically in 

MS Excel were compared to midpoint and upper bound values 

produced by the NIOSH-IREP code. 

2b. The entire probability distribution functions describing the uncertainty 

in the ERR and PC for selected cancers and exposure histories were 

independently produced using MS Excel/Crystal Ball and were 

compared to the probability distribution functions produced by the 

NIOSH-IREP code. 

4

 Crystal Ball® (Decisioneering 2000) is a specialized software for propagation of uncertainties using 

Monte-Carlo methods and operates as add-on to MS Excel® 

5

 The NIOSH-IREP code is too complex to be easily and completely reprogrammed into a programming 

environment such as Microsoft Excel®. However, the equations programmed in MS Excel cover, step-bystep, all calculations necessary to estimate probability of causation (PC) starting from a radiation dose 

received under any assumed single-exposure scenario. 
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The verification process described above identified three discrepancies between 

the algorithms implemented in NIOSH-IREP v.5.5.3 and the methodology described in 

its documentation that required modifications of the source code. The three discrepancies 

are discussed in detail in Section 3. 

The NIOSH-IREP v.5.5.3 source code has been subsequently modified to correct 

for the three issues identified in Section 3, and the updated version of the software will be 

referred to in this report as NIOSH-IREP v.5.5.3r (revised). Once the three revisions 

were made to NIOSH-IREP, the verification steps described above, including the entire 

set of verification calculations (presented in the appendices), were performed with 

v.5.5.3r to ensure that the corrections were made properly and that additional 

discrepancies do not exist. 
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3.0 Findings of the Verification Exercises 

A thorough check of the computer code was performed, involving a line-by-line 

comparison of the code with the technical documentation that describes how NIOSHIREP should operate, to ensure that all equations, models, and input parameters have 

been properly programmed in NIOSH-IREP. In addition, over 400 independent 

calculations (both deterministic and probabilistic) were performed using a stand-alone, 

scaled-down version of NIOSH-IREP. In general, the independent testing of NIOSHIREP v.5.5.3 confirmed that the code operates as intended. 

However, the verification effort identified three inconsistencies between the 

approach implemented in NIOSH-IREP v.5.5.3 and the approach described in its 

documentation that require modifications of the algorithms implemented in the source 

code. This section summarizes these findings. 

Acute Lymphocytic Leukemia Algorithm 

The verification exercises identified that NIOSH-IREP v.5.5.3 contains an 

algorithm for acute lymphocytic leukemia claims that is programmed incorrectly. For all 

types of leukemia (including acute lymphocytic leukemia), the dose response obtained 

from epidemiological data for cases of acute exposure to low-LET radiation is best 

represented by a linear-quadratic model. A linear dose response should be used for cases 

of exposure to high-LET radiation or low-LET radiation delivered at low-dose rates 

(chronic exposures; Land et al. 2003; page 27). If radiation dose is denoted by D, the 

ERR should be proportional to [D*(1+D)] for acute exposure to low-LET radiation and 

proportional to D for chronic exposures to low-LET radiation or exposures to high-LET 

radiation. 

Due to a misspelling of the word “lymphocytic” in the source code, NIOSH-IREP 

v.5.5.3 calculates ERR for acute lymphocytic leukemia as a linear function of dose D for 

all types of exposure, instead of using the linear-quadratic algorithm for acute exposures 

to low-LET radiation. This error affects only acute lymphocytic leukemia claims that 

involved acute exposures to low LET radiation. 
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The correction of this error has the potential to increase the PC results for acute 

lymphocytic leukemia claims, if the claim included acute exposures to low-LET 

radiation. A detailed discussion of this issue and its impact on acute lymphocytic 

leukemia claims is presented in Appendix A. 

Uncertainty in the Modifier for Age Dependency for Selected Cancers

The verification exercises also identified a difference between the IREP source 

code and its documentation (Land et al. 2003) for the algorithm that describe the 

uncertainty in the adjustment factor for the dependency of risk on age at exposure and 

attained age for all cancer types included in Group 2 (also called Approach 2 in Land et 

al. 2003). Land et al. (2003; page 26) indicate that the uncertainty in the age modifier for 

Group 2 cancers is described by a lognormal probability distribution with a geometric 

standard deviation (GSD) given by: 

GSD=exp{[0.0003261×f(e)2 -2×0.007297×f(e) ×g(a) +0.5648×g(a)2]

1/2} 

where e = age at exposure 

f(e)=-15 for e≤15; =e-30 for 15 ≤ e ≤ 30, and 0 for e>30 

a = attained age 

g(a) = ln(a/50) for 0≤a≤50, and =0 for a>50 

The NIOSH-IREP v.5.5.3 code (which was originally programmed in accordance 

with instructions received from NCI before publication of Land et al. 2003) does not 

include the multiplier 2 in front of the -0.007297×f(e) ×g(a) term of the equation above. 

For exposures at ages less than 30 and for ages at diagnosis ages less than 50, PC 

results obtained with the corrected equation are expected to have a slightly lower 

uncertainty (and thus a slightly lower 99th percentile of PC) than the PC results reported 

by NIOSH-IREP v.5.5.3. This difference does not affect PC results obtained for any 

Group 2 cancers diagnosed at ages 50 or older, or for any radiation exposures that 

occurred at ages 30 or older. A detailed discussion of this issue and its impact on PC 

results is presented in Appendix A. 
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Uncertainty in the Modifier for Age Dependency for the NIH Lung Model

The verification exercises further determined that the programming of the 

algorithm that describes the uncertainty in the adjustment factor for the dependency of 

risk on age at exposure and attained age for the NIH lung model is different from the 

algorithm in the documentation of the code (Land et al. 2003). 

The age modifier applied to the NIH lung model (Land et al. 2003; page 26) is 

described by a lognormal distribution with a GSD given by: 

GSD = exp{[0.06250×s2 

-2×0.0003469×s×f(e) +0.0003301×f(e)2 

+2×0.008295×s×g(a) -2×0.00708×f(e) ×g(a) +0.5620×g(a)2]

1/2} 

where s = -0.5 for males and s = +0.5 for females; and f(e) and g(a) are age at exposure 

(e) and attained age (a) functions described in the previous section: 

For males s is -0.5 and GSD becomes: 

GSD = exp{[0.015625

+2×0.00017345×f(e) +0.0003301×f(e)2

- 2×0.0041475×g(a) -2×0.00708×f(e) ×g(a) +0.5620×g(a)2]

1/2} 

For females s is +0.5 and the equation of GSD is: 

GSD = exp{[0.015625

- 2×0.00017345×f(e) +0.0003301×f(e)2

+2×0.0041475×g(a) -2×0.00708×f(e) ×g(a) +0.5620×g(a)2]

1/2} 

In the NIOSH-IREP v.5.5.3 code, the signs (+/-) associated with the f(e) and g(a) 

terms in the GSD for males are reversed. This has the effect of the expression of GSD 

for females being applied equally to males. This difference is expected to have only a 

minimal effect on PC results. A detailed discussion of this issue and its impact on PC 

results is presented in Appendix A. 
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4. Verification of Consistency between the Source Code and Its Documentation 

A member of the scientific team at SENES Oak Ridge, Inc. who had had no prior 

involvement in the NIOSH-IREP project (Dr. Kathleen Thiessen), served as the 

independent examiner for investigating the implementation of the code. Dr. Thiessen 

conducted a study to verify the consistency of the equations, assumptions, and numerical 

data implemented in the NIOSH-IREP source code, by comparing them with the 

equations, assumptions, and numerical data included in the formal technical 

documentation of the code. The primary description of the methodology for NIOSHIREP is considered to be Land et al. (2003) and Kocher et al. (2005, 2008) with reference 

to NIOSH (2002) for various details. The review was systematic, involving one section 

of material at a time. The review concentrated on the parts of the code involved in actual 

computations (parameter values and distributions, equations, decision points and the main 

parts for reporting results). Parts of the code used for reporting secondary results, 

completing summary pages, performing sensitivity or importance analysis, or checking 

(by the code developers) of sections of the code were not reviewed in detail. 

The verification of consistency between the source code and its documentation 

revealed a number of typographical errors that exist in the published documentation, but 

which are programmed correctly in the code itself: 

a. In the description of the risk model for exposure to radon (Land et al. 2003, 

page 30) the time since last exposure (t) is said to vary from 5 to 30 years. 

The correct range of variation for the time since last exposure is 5 to 25 years, 

as described elsewhere in Land et al. (2003). 

b. In the description of the risk model for lung cancer (Land et al. 2003, page 

26), the term accounting for the interaction between age at exposure (e) and 

age at diagnosis (a) is listed with a positive (+) sign, while the same risk 

model repeated in Table IV.D.3 of Land et al. (2003) has a negative (-) sign 

for that interaction term. The correct risk model is the one listed in Table 

IV.D.3 of Land et al. (2003) with a negative (-) sign for the term accounting 

for the interaction between age at exposure (e) and age at diagnosis (a). 
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c. In Table IV.D.2 of Land et al. (2003), the 50th percentile of the ERR at 1 Gy 

for rectal cancer in males is listed as 0.0812, while the correct value is 0.8196 

(according to original data files). 

d. Kocher et al. (2008, page 136), list the midpoint of the latency period for 

thyroid cancer as a triangular probability distribution with a minimum of 4.0 

years, mode of 4.5 years, and a maximum of 5.5 years [T(4.0, 4.5, 5.5)]. The 

correct triangular distribution for the midpoint of the latency period for 

thyroid cancer is a triangular probability distribution with a minimum of 3.0 

years (not 4 years), and the same mode of 4.5 years and maximum of 5.5 years 

[T(3.0, 4.5, 5,5)]. 

These typographical errors will be corrected by issuing errata statements for each 

of the supporting documents. However, they do not affect the algorithms, operation, or 

results of NIOSH-IREP v.5.5.3. 
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5. Deterministic Verification of Mid and Upper Values of ERR and PC 

NIOSH-IREP estimates ERR and PC as probability distribution functions (PDF) 

which can be interpreted to represent the uncertainty (i.e., the lack of knowledge) about 

the ERR and PC. These distributions are obtained using Monte-Carlo methods for 

propagation of uncertainties in all parameters involved in the calculations. A MonteCarlo method is a numerical approach in which a large number of random samples are 

generated for each uncertain parameter. The first random sample for the first parameter 

is combined with the first random sample of all other uncertain parameters to obtain a 

first estimate of ERR or PC. This process is repeated using a second set of samples, a 

third set of samples, and so on, until all random samples are used. The iterative process 

has a number of iterations6

 equal to the number of random samples generated. The 

collection of all estimates of ERR or PC are summarized as probability distribution 

functions (PDF) for ERR or PC, respectively. The PDFs are used to estimate any desired 

percentiles for ERR and PC (e.g., to obtain estimates of the 99th percentile of PC, which 

is required for the adjudication of individual claims in the EEOICPA program.) 

The purpose of the deterministic calculations presented in this section is to verify 

that the NIOSH-IREP code operates correctly for specific iterations of the Monte-Carlo 

process. Because the computing time for a single-iteration calculation is small, this 

verification step has been applied to every cancer type, for both males and females and 

for a number of selected ages at exposure and ages at diagnosis. For all cases analyzed, 

the verification has been carried out for two selected iterations from the PDFs obtained 

with NIOSH-IREP. One of the selected iterations is that which produces a result closest 

to the 99th percentile (referred to as “upper” throughout this report) of ERR and PC for 

each studied case. The other selected iteration is that which leads to a result closest to the 

50th percentile of ERR and PC (referred to as “mid” throughout this report). 

6

 Normally, NIOSH-IREP is operated by DOL and NIOSH using Monte-Carlo runs of 2000 iterations. 

When the 99th percentile of PC is between 45% and 52%, 30 Monte-Carlo runs of 10,000 iterations each 

are used. 
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A verification of the uncertainty propagation algorithms using probabilistic 

calculations relying on the full Monte-Carlo method was performed for a few selected 

cancer types, as described in Section 6. 

To perform the deterministic verification calculations for ERR and PC, the 

equations and data documented in Land et al. (2003) and Kocher et al. (2008) were 

programmed independently in a spreadsheet-based format (Microsoft Excel®). While 

NIOSH-IREP was not completely re-programmed in a spreadsheet programming 

environment, the equations programmed in MS Excel include all the steps necessary to 

estimate ERR and PC starting from a radiation dose received under any assumed singleexposure scenario. A version of the model was also programmed in MS Excel to allow 

the estimation of ERR and PC from up to 5 exposures (see Section 5.8). 

The primary goal of the calculations that were programmed in MS Excel was to 

assure that the general equations used by NIOSH-IREP were programmed correctly. 

Two sets of calculations have been performed to produce ERR and PC, but also report 

several additional intermediate results. Input parameters (obtained from the relevant 

distributions) used in NIOSH-IREP (v.5.5.3r) to generate results closest to the 50th and 

99th percentile values for selected scenarios (defined by cancer type, age, gender, etc.) 

were used as the input values for the deterministic calculations. 

The calculations have been separated into eight sets, each targeted to verify a 

different aspect of the ERR and PC calculation: 

- testing of primary equations for each cancer type 

- testing of the equations for minimum latency period 

- testing of the implementation of the radiation effectiveness factor 

- testing of the implementation of the dose and dose rate effectiveness factor 

- testing for the effect of ethnic origin on risk of skin cancer 

- testing for the effect of smoking on risk of lung cancer for non-radon exposures 

- testing for the effect of smoking on the risk of lung cancer for radon exposures 

- testing of the implementation of equations used for multiple exposures 
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The following sub-sections are dedicated to each of the eight sets of deterministic 

verification calculations. The results of the deterministic calculations are provided in 

Appendices B through I. For each calculation, results from NIOSH-IREP v.5.5.3r and 

the MS Excel calculator are presented side by side for comparison. 
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5.1 Testing Primary Equations for Each Cancer Type 

This set of verification calculations is the most comprehensive group of deterministic 

calculations, covering all cancer types, both genders and a relevant selection of age at 

exposure and age at diagnosis. 

The cancer types in NIOSH-IREP can be divided into four groups (Kocher et al. 

2008). Cancers in Group 1 and 2 have risk models indicating that, for a given age at 

diagnosis, the risk decreases with increasing age at exposure between ages 15 and 30, 

with risk being constant for exposures at ages greater than 30. For a given age at 

exposure, the risk for Group 1 and 2 cancers decreases linearly with increasing age at 

diagnosis up to age 50, after which risk is constant. The verification calculations for 

Group 1 and 2 cancers include four scenarios which combine ages at exposure 20 and 40 

and ages at diagnosis of 40 and 60, with one scenario for each interval with a specific 

variation of risk with age. 

The combinations of ages at exposure and attained ages for Groups 1 and 2 were also 

applied for Group 3 cancers, for which the risk models indicate that the risk is constant 

for all ages at exposure and all ages at diagnosis. 

The skin cancers (malignant melanoma, basal cell and squamous cell carcinoma) are 

part of Group 4. For a given age at diagnosis, their risk decreases with increasing age at 

exposure between ages 10 and 40, with risk being constant for exposures at ages greater 

than or equal to 40. The risk of skin cancer does not change with age at diagnosis. Thus, 

for skin cancers, exposure scenarios with the same combinations of ages at exposure and 

attained ages used for Groups 1 and 2 have been applied. 

For the other five cancers in Group 4 (thyroid, leukemia, ALL, AML, and CML), 

four exposure scenarios were defined using ages at exposure 20 and 60 and ages at 

diagnosis 40 and 80 (Table 1). The risk of thyroid cancer does not depend on attained 

age, but it decreases with increasing age at exposure up to age 55, beyond which the risk 

is constant. The risk for all leukemia (less CLL), for a fixed time since exposure, 

decreases with increasing age at exposure up to age 55 and is constant afterwards. The 

risk of acute lymphocytic leukemia (ALL) is constant for ages at exposure greater than 
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20, but for ages at exposure less than 20 it decreases exponentially with increasing time 

since exposure between 5 and 50 years after exposure, beyond which it is constant. Other 

than ALL, the risk for any of the leukemia types always decreases with increasing time 

since exposure between 5 and 50 years after exposure, and is constant outside this 

interval. 

All thirty-two cancers listed in NIOSH-IREP were used in this set of verification 

calculations. Twenty-eight of the cancers had four scenarios; four of the cancers had 

three scenarios (three of the cancers specific to females and one to males). 

All calculations assume a single acute radiation exposure to a dose of 20 cSv of high 

energy photons (E >250 keV). The radiation type was set to high energy photons (E > 

250 keV) because the radiation effectiveness factor (REF) for this radiation type is equal 

to 1.0 (i.e., no adjustments due to radiation type are needed). Exposure scenarios which 

include exposures to radiation types with an REF different than 1.0 are addressed in 

detail in Section 5.3. Similarly, a photon dose of 20 cSv delivered acutely was selected 

because the application of a DDREF is not necessary for such a dose. A detailed 

verification of the application of the DDREF is covered in Section 5.4. 

Table 1 presents a list of the scenarios considered for this set of deterministic 

calculations and provides the pages in Appendix B where the results are shown. Table 1 

also includes an indication of whether a particular cancer model is dependent on age at 

exposure, attained age (age at which a cancer was diagnosed), gender, or time since 

exposure (number of years between exposure and diagnosis). A total of 124 calculations 

were performed for this specific verification task. 

The ERR and PC results obtained with MS Excel verify that the mid and upper 

estimates given by NIOSH-IREP v.5.5.3r are correct, for all cancer types, both genders 

and for all exposure scenarios considered. 
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Table 1. Cancer types and exposure scenarios used for general verification calculations. 

Page number in Appendix B 

Run ID Cancer Type 

AAEa

=20

ATAa

=60

Male 

AAE=40

ATA=60

Male 

AAE=20 

ATA=40 

Male 

AAE=20

ATA=60

Female 

1 Oral Cavity and Pharynx B-1 B-2 B-3 B-4 

2 Esophagus B-5 B-6 B-7 B-8 

3 Stomach B-9 B-10 B-11 B-12 

4 Colon B-13 B-14 B-15 B-16 

5 Rectum B-17 B-18 B-19 B-20 

6 All digestive B-21 B-22 B-23 B-24 

7 Liver B-25 B-26 B-27 B-28 

8 Gallbladder B-29 B-30 B-31 B-32 

9 Pancreas B-33 B-34 B-35 B-36 

10 Lungb B-37 B-38 B-39 B-40 

11 Other respiratory B-41 B-42 B-43 B-44 

12 Bone B-45 B-46 B-47 B-48 

13 Connective tissue B-49 B-50 B-51 B-52 

14 Malignant melanomac B-53 B-54 B-55 B-56 

15 Non-melanoma (BCC)c B-57 B-58 B-59 B-60 

16 Non-melanoma (SCC)c B-61 B-62 B-63 B-64 

17 All Male Genitalia B-65 B-66 B-67 --- 

18 Bladder B-68 B-69 B-70 B-71 

19 Urinary organs (less bladder) B-72 B-73 B-74 B-75 

20 Eye B-76 B-77 B-78 B-79 

21 Nervous system B-80 B-81 B-82 B-83 

22 Other endocrine B-84 B-85 B-86 B-87 

23 Other and ill-defined sites B-88 B-89 B-90 B-91 

24 Lymphoma & multiple myeloma B-92 B-93 B-94 B-95 

Run ID Cancer Type 

AAE=20 

ATA=80 

Male 

AAE=60

ATA=80

Male 

AAE=20 

ATA=40 

Male 

AAE=20

ATA=80

Female 

25 Thyroid B-96 B-97 B-98 B-99 

26 Leukemia B-100 B-101 B-102 B-103 

27 Acute Lymphocytic Leukemia B-104 B-105 B-106 B-107 

28 Acute Myeloid Leukemia B-108 B-109 B-110 B-111 

29 Chronic Myeloid Leukemia B-112 B-113 B-114 B-115 

Run ID Cancer Type 

AAE=20 

ATA=60 

Female 

AAE=40

ATA=60

Female 

AAE=20 

ATA=40 

Female 

30 Breast B-116 B-117 B-118 

31 Ovary B-119 B-120 B-121 

32 Female Genitalia (less ovary) B-122 B-123 B-124 

a

 AAE = Age at exposure; ATA = Attained age (age at which cancer was diagnosed) 

b

 Calculations in Appendix B are representative of the NIOSH lung model. Calculations for the combined (NIOSH 

and NIH) lung model are described in Section 5.6, and calculations for the lung model used for radon exposures are 

described in Section 5.7. c Calculations in Appendix B represent White-non-Hispanic; Calculations for other races are described in Section 5.5. 
Verification of NIOSH-IREP July 2009 

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5.2 Testing Equations for Minimum Latency Period 

A specific set of calculations was made to verify that the algorithms describing 

the minimum latency period have been implemented correctly. The minimum latency 

period represents the minimum time required for a cancer to be observed in a population 

following a radiation exposure. 

In NIOSH-IREP, the excess relative risk for a given cancer is multiplied by an 

adjustment factor (an S-shaped function of time) to account for the latency period. This 

function increases from 0 (at the time of exposure) to 1 (after a transition period) and is 

dependent on cancer type. The latency adjustment is applied for exposures that occurred 

(1) within 5 years before a diagnosed leukemia, (2) within 8 years before a diagnosed 

thyroid or bone cancer, and (3) within 11 years before all other solid tumors. 

Calculations were completed for leukemia (representative of all types of 

leukemia), thyroid (also representative of bone cancer), and colon (representative of all 

other solid tumors) to ensure that the minimum latency period adjustment was 

programmed properly for each type of cancer. 

Calculations were performed for males and females receiving an acute dose of 

20 cSv from high energy photons, E > 250 keV. The assumption of an acute exposure to 

high energy photons causes the radiation effectiveness factor (REF) and the dose and 

dose rate effectiveness factor (DDREF) to be equal to 1.0. It should also be noted that 

the level of dose does not affect the minimum latency period adjustment. 

Because the latency adjustment is independent of age at time of exposure (AAE), 

the AAE was kept constant at 20 years. Five different scenarios were considered related 

to the number of years after exposure that the cancer was diagnosed. The times since 

exposure (TSE) used for these calculations are 2, 3, 5, 10, and 15 years. 

A total of 30 calculations was performed for this specific verification task. Table 2 

summarizes the scenarios used in these calculations and presents the page numbers in 

Appendix C where the results are shown. The results obtained with MS Excel verify that 

the mid and upper estimates given by NIOSH-IREP v.5.5.3r are correct, for all cancer 

types, both genders and for all exposure scenarios considered. 
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Table 2. Cancer types and exposure scenariosa used for verification of the 

implementation of the minimum latency period. 

Run Identifier Gender TSEb

 (years) Appendix Page 

Leukemia 

latency_leu_m1 Male 2 C-1 

latency_leu_m2 Male 3 C-2 

latency_leu_m3 Male 5 C-3 

latency_leu_m4 Male 10 C-4 

latency_leu_m5 Male 15 C-5 

latency_leu_f1 Female 2 C-6 

latency_leu_f2 Female 3 C-7 

latency_leu_f3 Female 5 C-8 

latency_leu_f4 Female 10 C-9 

latency_leu_f5 Female 15 C-10 

Thyroid 

latency_thy_m1 Male 2 C-11 

latency_thy_m2 Male 3 C-12 

latency_thy_m3 Male 5 C-13 

latency_thy_m4 Male 10 C-14 

latency_thy_m5 Male 15 C-15 

latency_thy_f1 Female 2 C-16 

latency_thy_f2 Female 3 C-17 

latency_thy_f3 Female 5 C-18 

latency_thy_f4 Female 10 C-19 

latency_thy_f5 Female 15 C-20 

Colon 

latency_col_m1 Male 2 C-21 

latency_col_m2 Male 3 C-22 

latency_col_m3 Male 5 C-23 

latency_col_m4 Male 10 C-24 

latency_col_m5 Male 15 C-25 

latency_col_f1 Female 2 C-26 

latency_col_f2 Female 3 C-27 

latency_col_f3 Female 5 C-28 

latency_col_f4 Female 10 C-29 

latency_col_f5 Female 15 C-30 

a

 All exposure scenarios assume a single acute exposure to high-energy photons at age 20. 

b

 Each cancer is assumed to be diagnosed between 2 and 15 years after exposure, given as time 

since exposure (TSE). 
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5.3 Testing Implementation of the Radiation Effectiveness Factor 

A series of calculations have been made to verify that the radiation effectiveness 

factor (REF) is implemented correctly in NIOSH-IREP. Radiation doses are entered in 

NIOSH-IREP by radiation type, and IREP converts an organ equivalent dose for a given 

radiation type in cSv to an absorbed dose (Gy). The radiation effectiveness factor (REF), 

which represents the biological effectiveness of a given radiation type, is used to modify 

the absorbed dose. 

The equation used to estimate ERR (and thus PC) depends on the radiation and 

cancer type of concern. For solid cancers, a different equation is used in cases of 

exposure to photons, electrons, or alpha particles than is used in cases of exposure to 

neutrons. For leukemia, different equations are used in cases of acute exposure to 

photons or electrons than are used in cases of chronic exposure to photons or electrons or 

any exposures to alpha particles or neutrons. A set of calculations have been made, for 

each of the 11 radiation types defined in NIOSH-IREP, to test the implementation of the 

REF in cases of leukemia from acute or chronic exposures. An additional set of 

calculations was performed to test the equations for solid cancers (represented by colon 

cancer) resulting from acute or chronic exposures. 

The equations related to REF do not depend on gender or on the value of the dose; 

therefore, all calculations were performed for males with an organ equivalent dose of 

20 cSv. The age at time of exposure (AAE) was kept constant at 20 years of age, and the 

age at diagnosis or attained age (ATA) was kept constant at 40 years of age. 

A total of 44 calculations was performed for this specific verification task. Table 3 

summarizes the scenarios used in these calculations and presents the page numbers in 

Appendix D where the results are shown. The results obtained with MS Excel verify that 

the mid and upper estimates given by NIOSH-IREP v.5.5.3r are correct, for all cancer 

types and for all exposure scenarios considered.
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Table 3. Cancer types and exposure scenariosa used for verification of the 

implementation of the radiation effectiveness factor. 

Appendix Page 

Run Leukemia Colon 

Identifier Radiation Type Acute Chronic Acute Chronic

REF_e1 electrons E < 15 keV D-1 D-2 D-3 D-4 

REF_e2 electrons E > 15 keV D-5 D-6 D-7 D-8 

REF_p1 photons E < 30 keV D-9 D-10 D-11 D-12 

REF_p2 photons E = 30 – 250 keV D-13 D-14 D-15 D-16 

REF_p3 photons E > 250 keV D-17 D-18 D-19 D-20 

REF_n1 neutrons E < 10 keV D-21 D-22 D-23 D-24 

REF_n2 neutrons E = 10 – 100 keV D-25 D-26 D-27 D-28 

REF_n3 neutrons E = 100 keV – 2 MeV D-29 D-30 D-31 D-32 

REF_n4 neutrons E = 2 – 20 MeV D-33 D-34 D-35 D-36 

REF_n5 neutrons E > 20 MeV D-37 D-38 D-39 D-40 

REF_a alpha D-41 D-42 D-43 D-44 

a

 All exposure scenarios assume a single acute exposure to high-energy photons (E > 250 keV). 

The exposure is assumed to occur to a male of age 20, with the cancer being diagnosed at 

age 40. 
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5.4 Testing Implementation of the Dose and Dose Rate Effectiveness Factor

 A set of calculations was performed to verify that the dose and dose rate 

effectiveness factor (DDREF) has been implemented correctly in NIOSH-IREP. In 

NIOSH-IREP, the ERR/Sv for all solid cancers (including lymphoma and multiple 

myeloma) resulting from exposure to low-LET radiations is assumed to depend on dose 

and dose rate. The DDREF is applied to estimates of ERR/Sv at high doses and high 

dose rates of high-energy photons in atomic-bomb survivors in order to estimate the 

ERR/Sv at low doses or low dose rates. 

In NIOSH-IREP, the value of the DDREF is applied as a function of the exposure 

rate (acute or chronic). The DDREF is applied to all chronic exposures. For an acute 

exposure, the DDREF is applied differently for doses less than 20 cSv than for doses 

larger than 20 cSv. To test all possible applications of DDREF, a series of calculations 

has been performed for chronic and acute exposures to each radiation type, assuming 

doses of 5 cSv and 30 cSv. 

The probability distribution of the DDREF in NIOSH-IREP is different for 

thyroid and breast cancers than for all other solid tumors. No DDREF is applied for any 

type of leukemia. Thus, separate verification calculations were performed for thyroid 

cancer, breast cancer, and colon cancer. (Colon cancer was selected to represent solid 

tumors other than breast and thyroid). The age at exposure (AAE) was kept constant at 

20 years of age, and the age at diagnosis (attained age, ATA) was kept constant at 40 

years of age. Because the DDREF is independent of gender, males were used for thyroid 

and colon cancer calculations; however females were used for breast cancer calculations. 

A total of 132 calculations was performed for this specific verification task. 

Table 4 summarizes the scenarios used in these calculations and presents the page 

numbers in Appendix E where the results are shown. The results obtained with MS Excel 

verify that the mid and upper estimates given by NIOSH-IREP v.5.5.3r are correct, for all 

cancer types and for all exposure scenarios considered.
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Table 4. Cancer types and exposure scenariosa used for verification of the 

implementation of the dose and dose rate effectiveness factor. 

Appendix Page 

Run Acute dose Chronic dose 

Identifier Radiation Type 5 cSv 30 cSv 5 cSv 30 cSv 

Thyroid 

DDREF_e1 electrons E < 15 keV E-1 E-2 E-3 E-4 

DDREF_e2 electrons E > 15 keV E-13 E-14 E-15 E-16 

DDREF_p1 photons E < 30 keV E-25 E-26 E-27 E-28 

DDREF_p2 photons E = 30 – 250 keV E-37 E-38 E-39 E-40 

DDREF_p3 photons E > 250 keV E-49 E-50 E-51 E-52 

DDREF_n1 neutrons E < 10 keV E-61 E-62 E-63 E-64 

DDREF_n2 neutrons E = 10 – 100 keV E-73 E-74 E-75 E-76 

DDREF_n3 neutrons E = 100 keV – 2 MeV E-85 E-86 E-87 E-88 

DDREF_n4 neutrons E = 2 – 20 MeV E-97 E-98 E-99 E-100 

DDREF_n5 neutrons E > 20 MeV E-109 E-110 E-111 E-112 

DDREF_a alpha E-121 E-122 E-123 E-124 

Colon 

DDREF_e1 electrons E < 15 keV E-5 E-6 E-7 E-8 

DDREF_e2 electrons E > 15 keV E-17 E-18 E-19 E-20 

DDREF_p1 photons E < 30 keV E-29 E-30 E-31 E-32 

DDREF_p2 photons E = 30 – 250 keV E-41 E-42 E-43 E-44 

DDREF_p3 photons E > 250 keV E-53 E-54 E-55 E-56 

DDREF_n1 neutrons E < 10 keV E-65 E-66 E-67 E-68 

DDREF_n2 neutrons E = 10 – 100 keV E-77 E-78 E-79 E-80 

DDREF_n3 neutrons E = 100 keV – 2 MeV E-89 E-90 E-91 E-92 

DDREF_n4 neutrons E = 2 – 20 MeV E-101 E-102 E-103 E-104 

DDREF_n5 neutrons E > 20 MeV E-113 E-114 E-115 E-116 

DDREF_a alpha E-125 E-126 E-127 E-128 

Breast 

DDREF_e1 electrons E < 15 keV E-9 E-10 E-11 E-12 

DDREF_e2 electrons E > 15 keV E-21 E-22 E-23 E-24 

DDREF_p1 photons E < 30 keV E-33 E-34 E-35 E-36 

DDREF_p2 photons E = 30 – 250 keV E-45 E-46 E-47 E-48 

DDREF_p3 photons E > 250 keV E-57 E-58 E-59 E-60 

DDREF_n1 neutrons E < 10 keV D69 E-70 E-71 E-72 

DDREF_n2 neutrons E = 10 – 100 keV E-81 E-82 E-83 E-84 

DDREF_n3 neutrons E = 100 keV – 2 MeV E-93 E-94 E-95 E-96 

DDREF_n4 neutrons E = 2 – 20 MeV E-105 E-106 E-107 E-108 

DDREF_n5 neutrons E > 20 MeV E-117 E-118 E-118 E-120 

DDREF_a alpha E-129 E-130 E-131 E-132 

a

 The exposure is assumed to occur at age 20, with the cancer being diagnosed at age 40. 
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5.5 Testing the Effect of Ethnic Origin on Risk of Skin Cancer 

 Separate independent calculations have been made to verify that the adjustment 

accounting for the interaction between ionizing and UV radiation is implemented 

correctly in NIOSH-IREP. This interaction is modeled in NIOSH-IREP by accounting 

for ethnic differences in baseline risks of skin cancer for applying ERRs in Japanese 

atomic-bomb survivors to the U.S. population. This interaction applies to three types of 

skin cancer: malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. 

The effect of ethnic origin does not depend on age, radiation type, or exposure 

rate (acute or chronic). Thus, the calculations performed for this exercise assume an acute 

exposure to high energy photons (E>250 keV), the age at exposure (AAE) was kept 

constant at 20 years, and the attained age (ATA) was kept constant at 40 years. The 

verification calculations were performed for males only under the assumption of a single 

acute exposure to a dose of 20 cSv. 

A total of 15 calculations was performed for this specific verification task. Table 

5 summarizes the scenarios used in these calculations and presents the page numbers in 

Appendix F where the results are shown. The results obtained with MS Excel verify that 

the mid and upper estimates given by NIOSH-IREP v.5.5.3r are correct, for all cancer 

types and for all exposure scenarios considered.
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Table 5. Cancer types and exposure scenariosa used for verification of the 

implementation of the effect of ethnic origin. 

Run Identifier Ethnic origin Appendix Page # 

Malignant Melanoma 

Ethnic_MM_1 American Indian F-1 

Ethnic_MM_2 Asian F-2 

Ethnic_MM_3 Black F-3 

Ethnic_MM_4 Hispanic F-4 

Ethnic_MM_5 White non-Hispanic F-5 

Non-melanoma Basal Cell Carcinoma 

Ethnic_BCC_1 American Indian F-6 

Ethnic_BCC_2 Asian F-7 

Ethnic_BCC_3 Black F-8 

Ethnic_BCC_4 Hispanic F-9 

Ethnic_BCC_5 White non-Hispanic F-10 

Non-melanoma Squamous Cell Carcinoma 

Ethnic_SCC_1 American Indian F-11 

Ethnic_SCC_2 Asian F-12 

Ethnic_SCC_3 Black F-13 

Ethnic_SCC_4 Hispanic F-14 

Ethnic_SCC_5 White non-Hispanic F-15 

a

 All scenarios are for a male acutely exposed to 20 cSv of high-energy photons 

(E > 250 keV) at age 20, with the cancer being diagnosed at age 40.
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5.6 Testing the Effect of Smoking on the Risk of Lung Cancer for 

non-Radon Exposures 

A set of calculations has been performed to ensure that the interaction effect 

between smoking and radiation exposures (non-radon) has been properly programmed in 

NIOSH-IREP for estimating the risk of lung cancer. NIOSH-IREP incorporates two risk 

models for lung cancer (the NIH lung model and the pre-2006 NIOSH lung model). The 

lung cancer model used by NIOSH-IREP is referred to as a “combined” lung model. 

Both models to estimate risk for lung cancer due to sources of exposure other than 

radon take into account an interaction between radiation and smoking history. The 

calculations have been performed to test the combined lung model and report the 99th

percentile PC value that is the largest of the two methods. 

Calculations were performed separately for males and females and assume an 

acute exposure to 20 cSv of high energy photons, E > 250 keV. The age at exposure 

(AAE) was kept constant at 20 years of age, and the attained age (ATA) was kept 

constant at 40 years of age. A total of 14 calculations was performed for this specific 

verification task. Table 6 summarizes the scenarios used in these calculations and 

presents the page numbers in Appendix G where the results are provided. The results 

obtained with MS Excel verify that the mid and upper estimates given by NIOSH-IREP 

v.5.5.3r are correct for both genders and for all exposure scenarios considered. 

Table 6. Exposure scenariosa

 used to verify the implementation of the smoking 

interaction for non-radon exposures. 

Appendix Page # 

Run Identifier Smoking Category Male Female 

Lung_other_1 Never smoked G-1 G-8 

Lung_other_2 Former smoker G-2 G-9 

Lung_other_3 ?? cigarettes/day G-3 G-10 

Lung_other_4 <10 cigarettes/day G-4 G-11 

Lung_other_5 10-19 cigarettes/day G-5 G-12 

Lung_other_6 20-39 cigarettes/day G-6 G-13 

Lung_other_7 >40 cigarettes/day G-7 G-14 a

 All scenarios are for an acute exposure to 20 cSv of high-energy photons (E > 250 keV) at 

age 20, with the cancer being diagnosed at age 40.
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5.7 Testing the Effect of Smoking on the Risk of Lung Cancer for Radon 

Exposures

A series of calculations has been performed to ensure that the interaction effect 

between smoking and radon exposures has been properly programmed in NIOSH-IREP 

for estimating the risk of lung cancer. The risk for lung cancer due to exposure to radon is 

modeled as a function of the cumulative exposure to short-lived, alpha-emitting decay 

products in units of working level months (WLM). 

Although the radon risk model used in NIOSH-IREP is assumed to be 

independent of gender, calculations were performed separately for males and females, for 

purposes of verification. As in the models for lung cancer due to sources of exposure 

other than radon, ERRs for lung cancer due to exposure to radon are assumed to depend 

on smoking history. However, only two smoking categories are specified in the risk 

methodology—smokers and nonsmokers (Land et al. 2003). 

Smoking history was defined as “never smoked” (to represent a nonsmoker) or 

having a smoking history of between 20 and 39 cigarettes per day (to represent a 

smoker). The age at exposure (AAE) was varied between 20 and 75 years, while the 

attained age (ATA) was varied between 40 and 80 years. 

A total of 36 calculations was performed to verify this specific task. Table 7 

summarizes the scenarios used in these calculations and provides the page numbers in 

Appendix H where the detailed results for this exercise are found. The results obtained 

with MS Excel verify that the mid and upper estimates given by NIOSH-IREP v.5.5.3r 

are correct, for both genders and for all exposure scenarios considered. 
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Table 7. Exposure scenariosa used to verify the implementation of the smoking 

interaction for radon exposures. 

Appendix Page # 

Run Identifier AAEb ATAc Male Female 

Non-Smoker 

Lung_radon_ns_1 20 40 H-1 H-19 

Lung_radon_ns_2 35 40 H-2 H-20 

Lung_radon_ns_3 20 60 H-3 H-21 

Lung_radon_ns_4 40 60 H-4 H-22 

Lung_radon_ns_5 55 60 H-5 H-23 

Lung_radon_ns_6 20 80 H-6 H-24 

Lung_radon_ns_7 40 80 H-7 H-25 

Lung_radon_ns_8 60 80 H-8 H-26 

Lung_radon_ns_9 75 80 H-9 H-27 

Smoker (20-39 cigarettes/day) 

Lung_radon_sm_1 20 40 H-10 H-28 

Lung_radon_sm_2 35 40 H-11 H-29 

Lung_radon_sm_3 20 60 H-12 H-30 

Lung_radon_sm_4 40 60 H-13 H-31 

Lung_radon_sm_5 55 60 H-14 H-32 

Lung_radon_sm_6 20 80 H-15 H-33 

Lung_radon_sm_7 40 80 H-16 H-34 

Lung_radon_sm_8 60 80 H-17 H-35 

Lung_radon_sm_9 75 80 H-18 H-36 

a

 All scenarios are for a radon exposure at a level of 1 WLM 

b

 AAE = Age at exposure 

c

 ATA = Attained age (age at which cancer was diagnosed) 
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5.8 Testing the Implementation of Multiple Exposures Algorithms

NIOSH-IREP has the capability to estimate probability of causation from up to 

1,000 exposures. A series of calculations has been performed to ensure that NIOSHIREP properly estimates PC in cases involving multiple radiation exposures. 

A series of 5 calculations was performed for this verification task. Various 

combinations of gender, cancer type, age at time of exposure, time exposure and 

diagnosis, organ dose, exposure rate, and radiation type were chosen. Five exposures 

were assumed for the first 4 scenarios and three exposures were assumed for the 5th

scenario. The details of each scenario are described in the results tables presented in 

Appendix I. 

Table 8 summarizes the scenarios used in these calculations and provides the page 

numbers where the detailed results for this exercise are found. The results obtained with 

MS Excel verify that the mid and upper estimates given by NIOSH-IREP v.5.5.3r are 

correct for both genders and for all exposure scenarios considered. 

Table 8. Exposure scenarios used to verify the implementation of multiple exposure 

algorithms. 

Cancer No. of 

NIOSH-IREP 

v.5.5.3r 

MS Excel 

Calculation 

Run Identifier Type Exposures Mid Upper Mid Upper 

Mult Exp 1 Colon 5 I-1 I-2 I-3 I-4 

Mult Exp 2 Breast 5 I-5 I-6 I-7 I-8 

Mult Exp 3 Thyroid 5 I-9 I-10 I-11 I-12 

Mult Exp 4 Skin (BCC) 5 I-13 I-14 I-15 I-16 

Mult Exp 5 Liver 3 I-17 I-18 I-19 I-20 
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6. Verification of Monte-Carlo Uncertainty Propagation Algorithms 

The deterministic calculations described in Section 5 of this report verify that 

NIOSH-IREP operates correctly for at least two iterations of the Monte-Carlo method for 

propagation of uncertainties; that is, for the iteration that produces a result closest to the 

50th percentile of ERR and PC and for the iteration that produces a result closest to the 

99th percentile of ERR and PC. 

The purpose of the calculations discussed in this section is to verify that the 

Monte-Carlo uncertainty propagation algorithm used in NIOSH-IREP operates properly. 

In these verification calculations, probability distribution functions for ERR and PC 

produced by NIOSH-IREP are compared to probability distribution functions for ERR 

and PC obtained from the independent programming of the risk models into Microsoft 

Excel® combined with Crystal Ball®. The risk models programmed in MS 

Excel/Crystal Ball contain all parameters defined using the probability distributions listed 

in the technical documentation of NIOSH-IREP (NIOSH 2002; Land et al. 2003; Kocher 

et al. 2008). 

The verification calculations based on Monte-Carlo sampling procedures are 

affected by random noise introduced by this numerical sampling method. For example, 

DOL normally analyzes claims using NIOSH-IREP with Monte-Carlo runs having 

sample size of 2,000 iterations. In these cases, the 99th percentile of PC can vary by 

several percentage points if the random seed of the Monte-Carlo sampling procedure is 

changed. However, for claims in which the 99th percentile of PC from a Monte-Carlo 

sample size of 2,000 is between 45% and 52%, DOL uses the Enterprise Edition7

 of 

NIOSH-IREP to produce 30 Monte-Carlo runs of 10,000 iterations each. In this case, the 

margin of error for the 99th percentile of PC is only about ±0.5 percentage points (i.e., a 

PC99 that is truly equal to 50% may be between a reported PC99 of 49.5% and 50.5%). 

For percentiles closer to the center of the probability distribution, the margin of error is 

much smaller than the margin of error of the 99th percentile. 

7

 The Enterprise Edition of NIOSH-IREP uses the same version of the NIOSH-IREP source code (e.g., 

v.5.5.3r), but allows the user to repeat runs a number of times. The Enterprise Edition is designed to run 

NIOSH-IREP thirty times, each run having a sample size of 10,000, and initiated with a different random 

number seed. The 99th percentile of the combined 30 × 10,000 iterations is obtained as the average of the 

99th percentiles from each of the 30 individual 10,000-iteration runs. 
Verification of NIOSH-IREP July 2009 

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An important aspect of this verification exercise is that the random number 

generators used by Analytica® (the programming language for NIOSH-IREP) and MS 

Excel/Crystal Ball are different. In addition, NIOSH-IREP uses a Median Latin 

Hypercube Sampling (LHS) technique, while Crystal Ball® uses a slightly different 

Random Latin Hypercube Sampling (LHS) technique. This means that, if for a given 

calculation NIOSH-IREP uses one sequence of random numbers, the exact same 

calculation in MS Excel/Crystal Ball, using exactly the same random seed, will produce a 

different set of random numbers. This difference in random numbers has a similar effect 

to the effect introduced by simply changing the random seed in NIOSH-IREP. Thus, two 

Monte-Carlo calculations, one in NIOSH-IREP and one in MS Excel/Crystal Ball are not 

identical, but they should not differ by more than the margin of error for a Monte-Carlo 

operation (as discussed above). 

Verification calculations for this section were performed first using a LHS sample 

size of 2,000 followed by 30 individual runs of 10,000 iterations each. Comparisons 

based on the 30 runs of 10,000 iterations minimize the differences in ERR and PC due to 

differences in the random number generator used by the Analytica® and Crystal Ball® 

software packages. Because the same Monte-Carlo uncertainty propagation algorithm in 

NIOSH-IREP applies to all cancers types and exposure scenarios, verification 

calculations presented in this section were performed only for a few selected cancer types 

(oral cavity, colon, bladder, and nervous system) and for two combinations of ages at 

exposure and ages at diagnosis (Table 9). All scenarios considered for this set of 

verification calculations represent males exposed to an acute dose of 20 cSv of high 

energy photons (E > 250 keV). 

Table 9 summarizes the exposure scenarios and pages in Appendix J where the 

detailed results can be found. The results of the Monte-Carlo calculations are presented 

both in tabular and graphical form (Appendix J). The tables of results show the 1st, 5th, 

50th, 95th and 99th percentiles of the probability distributions obtained by Monte-Carlo 

methods in NIOSH-IREP and in MS Excel/Crystal Ball for each of the 30 runs of 10,000 

iterations and show the average of the 30 runs at each of the five percentiles selected for 

verification testing. The graphs included in Appendix J are probability plots comparing 
Verification of NIOSH-IREP July 2009 

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 31 

the entire probability distributions for ERR and PC produced by NIOSH-IREP and by 

MS Excel/Crystal Ball using a Monte-Carlo LHS sample size of 2,000. 

The results in Appendix J show that the probability distributions for ERR and PC 

produced by NIOSH-IREP were successfully reproduced by independent programming 

of the risk models in MS Excel/Crystal Ball. Any percentile of the probability 

distributions for ERR and PC produced by MS Excel/Crystal Ball was not different from 

the same percentile produced by NIOSH-IREP by more than the margin of error 

introduced by the random noise of the Monte-Carlo method. This was true for either a 

regular 2,000-iteration run, or cases in which 30 runs of 10,000 iterations were used. The 

verification calculations produced for this report indicate that the Monte-Carlo 

uncertainty propagation algorithm in NIOSH-IREP operates properly. 

Table 9. Exposure scenariosa used for verification of Monte-Carlo uncertainty 

propagation algorithms 

Appendix Page 

Tabular Resultsd Graphse

Case Cancer Type AAEb ATAc ERR PC ERR&PC

1 Oral Cavity & Pharynx 40 60 J-1 J-2 J-4 

2 Colon 20 60 J-5 J-6 J-8 

3 Bladder 40 60 J-9 J-10 J-12 

4 Nervous System 20 60 J-13 J-14 J-16 

a

 All scenarios represent males exposed to an acute and constant dose of 20 cSv of high 

energy photons (E > 250 keV). 

b

 AAE = Age at exposure 

c

 ATA = Attained age (age at which cancer was diagnosed) 

d

 Tabular results compare the 1st, 5th, 50th, 95th, and 99th percentiles from 30 runs of 10,000 

iterations each. e

 Graphical results compare the entire probability distribution from a single run of 2,000 

iterations. 
Verification of NIOSH-IREP July 2009 

SENES Oak Ridge, Inc. 

 32 

7. Summary and Conclusions 

This report presents the results of a formal verification exercise designed to 

ensure that the most current version of the NIOSH-IREP software calculates risk and the 

probability of causation (PC) according to the methodology described in its technical 

documentation (NIOSH 2002; Land et al. 2003; Kocher et al. 2008). 

The NIOSH-IREP methodology for estimation of risk and probability of causation 

was developed by a working group of the National Cancer Institute (NCI) and the Centers 

for Disease Control and Prevention (CDC), and it was reviewed internally by NCI and 

externally by an NCI advisory committee, by a committee of the National Academy of 

Sciences (NAS), and by the NIOSH Office of Compensation Analysis and Support 

(NIOSH-OCAS) prior to the adoption of NIOSH-IREP as the main computational tool in 

the EEOICPA compensation program. 

The NIOSH-IREP software itself has been tested numerous times by its 

developers (SENES Oak Ridge, Inc.), by NIOSH–OCAS staff (before and after its official 

release in April 2002), and by DOL staff who use the code on a daily basis. Comments 

about the operation of the software have also been received from members of the public 

who have used NIOSH-IREP. A list of software updates resulting from previous phases 

of testing of NIOSH-IREP is posted at (www.niosh-irep.com/irep_niosh/update.asp). 

The verification of the NIOSH-IREP source code included the following 

operations: 

1. The mathematical equations of the risk models and associated numerical data 

implemented in the NIOSH-IREP source code were compared with the equations 

described in the documentation of NIOSH-IREP. 

2. The mathematical equations and numerical data of the risk models used by 

NIOSH-IREP were independently programmed using MS Excel and Crystal Ball, 

creating a scaled-down version of the code8

 that could be used for verification. 

 

8

 The equations programmed in MS Excel cover all the steps necessary to estimate probability of causation 

(PC) starting from a radiation dose received under any assumed single-exposure scenario. 
Verification of NIOSH-IREP July 2009 

SENES Oak Ridge, Inc. 

 33 

2c. Values of the risk model parameters corresponding to a mid and upper 

estimate of ERR and PC produced by NIOSH-IREP were used as input for 

deterministic calculations in MS Excel, for all cancer types and various 

selected exposure scenarios. Estimates of the mid and upper values 

calculated deterministically in MS Excel were compared to the results 

produced by the NIOSH-IREP code. 

2d. The entire probability distribution functions describing the uncertainty in 

the ERR and PC for selected cancers and exposure histories were 

independently produced using MS Excel/Crystal Ball and were compared 

to the probability distribution functions produced by the NIOSH-IREP 

code. 

The verification process described above identified three discrepancies between 

the algorithms implemented in NIOSH-IREP v.5.5.3 and the methodology described in 

its documentation. NIOSH-IREP v.5.5.3 was subsequently revised to correct for these 

issues. The updated and revised version of the source code is referred to as NIOSH-IREP 

v.5.5.3r. The formal verification procedures, including all deterministic and probabilistic 

calculations, were repeated using NIOSH-IREP v.5.5.3r. All results presented in 

Appendix B through Appendix J of this report refer to testing conducted on NIOSH-IREP 

v.5.5.3r. 

The verification of consistency between the source code and its documentation 

revealed four typographical errors that exist in the published documentation, but are 

programmed correctly in the NIOSH-IREP v.5.5.3 source code itself. These 

typographical errors will be corrected using errata statements. 

More than 400 deterministic verification calculations were performed, covering 

all cancer types for both genders. Special attention was paid to modifiers of risk related 

to the minimum latency period, the radiation effectiveness factor (REF), the dose and 

dose-rate effectiveness factor (DDREF), the effect of ethnic origin on risk of skin cancer, 

and the effect of smoking on risk of lung cancer. Deterministic calculations were 

performed to check ERR and PC for all intervals of variation for these modifiers. 
Verification of NIOSH-IREP July 2009 

SENES Oak Ridge, Inc. 

 34 

The deterministic calculations show that the 50th and 99th percentiles of ERR and 

PC estimated by NIOSH-IREP were successfully reproduced by independent calculations 

setup in MS Excel for all cancer types, both genders and for all exposure scenarios 

considered. This exercise demonstrates that NIOSH-IREP v.5.5.3r operates as intended 

for two of the percentiles from the probability distribution describing the uncertainty in 

the ERR and PC. 

The Monte-Carlo uncertainty propagation algorithms were verified using a 

separate set of probabilistic calculations. Probability distribution functions (PDFs) 

describing the uncertainty in the ERR and PC for selected exposure scenarios were 

generated by means of Monte-Carlo methods, first in NIOSH-IREP v.5.5.3r and then 

using the risk models independently programmed in MS Excel/Crystal Ball. The PDFs 

generated by NIOSH-IREP v.5.5.3r and by MS Excel/Crystal Ball were the same (i.e., 

they were not different by more than the small margin of error introduced by differences 

in the Monte-Carlo methods carried out by Analytica® and MS Excel/Crystal Ball. 

The results of the probabilistic calculations indicate that Monte-Carlo uncertainty 

propagation algorithms in NIOSH-IREP v.5.5.3r operate properly. Thus, it is expected 

that NIOSH-IREP v.5.5.3r produces reliable results not only for the 99th percentile of 

ERR and PC, but for any other percentile from the probability distribution describing the 

uncertainty in the ERR and PC. 
Verification of NIOSH-IREP July 2009 

SENES Oak Ridge, Inc. 

 35 

8. References 

Decisioneering, Inc. Crystal Ball 2000 Standard Edition; www.decisioneering.com; 1515 

Arapahoe St. Suite 1330, Denver, Colorado 2000. 

Kocher, D.C., Apostoaei, A.I., Henshaw, R.W., Hoffman, F.O., Schubauer-Berigan, 

M.K., Stancescu, D.O., Thomas, B.A., Trabalka, J.R., Gilbert, E.S., Land, C.E. 

Interactive Radioepidemiological Program (IREP): A web-based tool for 

estimating probability of causation/assigned share of radiogenic cancers. Health 

Physics 95(1):119-147; 2008. 

Kocher, D.C., Apostoaei, A.I., Hoffman, F.O. Radiation Effectiveness Factors for Use in 

Calculating Probability of Causation of Radiogenic Cancers. Health Physics 

89(1): 3-32; 2005. 

LANL (Los Alamos National Laboratory). Concepts of Model Verification and 

Validation. LA-14167-MS, Los Alamos, NM. 2004. 

Land, C., Gilbert, E., Smith, J., Hoffman, F.O., Apostoaei, I.A., Thomas, B.A., Kocher, 

D.C. Report of the NCI-CDC Working Group to Revise the 1985 NIH 

Radioepidemiological Tables. Bethesda, MD: NIH/NCI. 2003. 

NAS/NRC Committee on an Assessment of Centers for Disease Control and Prevention 

Radiation Studies from DOE Contractor Sites: Subcommittee to Review the 

Radioepidemiological Tables. A Review of the Draft Report of the NCI-CDC 

Working Group to Revise the “1985 Radioepidemiological Tables”. Washington, 

DC: National Research Council, Board on Radiation Effects Research, 2000. 

National Institute for Occupational Safety and Health. NIOSH Interactive 

RadioEpidemological Program (NIOSH-IREP) technical documentation. 

Cincinnati, OH: Office of Compensation Analysis and Support, National Institute 

of Occupational Safety and Health; 2002. Available at: 

http://www.cdc.gov/niosh/ocas/pdfs/irep/irepfnl.pdf. 

U.S. Department of Health and Human Services. 42 CFR Part 81—Guidelines for 

determining the probability of causation under the Energy Employees 

Occupational Illness Compensation Program Act of 2000; final rule. Fed Reg 

67:22296–22314; 2002. 
VERIFICATION OF NIOSH-IREP COMPUTER CODE 

Version 5.5.3 

Appendices 

July 2009 

Deterministic Verification of the 50th and 99th Percentiles of ERR and PC

Appendix A Effects of the Findings on PC results produced by NIOSH-IREP 

Appendix B General Verification Calculations 

Appendix C Verification of the Implementation of the Minimum Latency Period 

for Leukemia, Thyroid, and Solid Tumor Cancers 

Appendix D Verification of the Implementation of the Radiation Effectiveness 

Factors (REF) for Exposure to Alpha Radiation, Neutrons, and Low 

Energy Photons and Beta Particles 

Appendix E Verification of the Implementation of the DDREF for Low Dose and 

High Dose Acute and Chronic Exposures 

Appendix F Effect of Ethnic Origin on the ERR per Unit Dose for Skin Cancer 

Appendix G Effect of Cigarette Smoking on the Risk of Lung Cancer (non-Radon 

Exposures) 

Appendix H Effect of Cigarette Smoking on the Risk of Lung Cancer from Radon 

Exposures 

Appendix I Verification of the Implementation of Multiple Exposures Algorithms 

Probabilistic Verification of Monte-Carlo Uncertainty Propagation

Appendix J Results of Testing the Monte Carlo Uncertainty Propagation 

Algorithms 
Appendix A 

Effects of the Findings on PC results produced by NIOSH-IREP 

This Appendix presents an analysis of the magnitude of changes in PC values 

resulting from the three discrepancies identified during independent testing of NIOSHIREP v.5.5.3. The analysis of PC was performed using the methods described below. 

A revised version of NIOSH-IREP was created that includes all corrections to the 

issues described in Section 3 of this report. The revised version of the code is referred to 

NIOSH-IREP v.5.5.3r. 

The PC was calculated for a number of selected exposure scenarios using both 

NIOSH-IREP v.5.5.3 and NIOSH-IREP v.5.5.3r. The exposure scenarios relevant for 

each of the three findings were selected with the intent of producing the largest possible 

difference in the PC results. The selected scenarios were kept very simple (e.g., a single 

exposure to one radiation type) to minimize calculation time. For more realistic exposure 

histories, such as those in the claims handled by NIOSH and DOL, the differences 

between NIOSH–IREP v.5.5.3 and v.5.5.3r are expected to be much smaller than the 

differences presented in this report. 

The radiation doses for each exposure scenario were selected so that the 99th

percentile of PC produced by NIOSH-IREP v.5.5.3 was near 50%, the level required for 

compensation of a claim. The results of this analysis indicate whether the modification 

implemented in NIOSH-IREP v.5.5.3r produces a 99th percentile of PC larger or smaller 

than that given by NIOSH-IREP v.5.5.3. 

To minimize the random noise effect of Monte-Carlo sampling, all testing 

calculations for v.5.5.3 and v.5.5.3r were performed using 30 runs of 10,000 iterations 

each (i.e., using the Enterprise Edition for each version of the code). Normally, DOL 

analyzes claims using NIOSH-IREP runs of 2000 iterations each. In these cases, the 99th

percentile of PC can vary by up to ± 5 percentage points if the random seed were changed 

(i.e., a PC99 that is truly equal to 50% may be reported anywhere between 45% to 55%.) 

However, the PC99 estimated from a calculation using 30 runs of 10,000 iterations each 

will have a margin of error of only about ±0.5 percentage points if a different set of 30 

random number seeds was used for each run (i.e., a PC99 that is truly equal to 50% may 

be between a reported PC99 of 49.5% and 50.5%). Therefore, the results of this testing 
exercise can be considered to represent actual differences introduced by the corrections to 

the code, and not be due to random noise of the Monte-Carlo calculation. For the 

purposes of this exercise, the same set of 30 random number seed values was used for all 

calculations. 

Throughout this section, we compare the 99th percentiles of PC estimated by 

NIOSH-IREP v.5.5.3 to the 99th percentile of PC estimated by NIOSH-IREP v.5.5.3r. To 

keep the text short and easy to read, we often use an abbreviated language saying that we 

compare “the PC99 estimated by v.5.5.3” to “PC99 estimated by v.5.5.3r.” 

Issue 1: Acute Lymphocytic Leukemia Algorithm

For exposures at age 20 or greater, the risk model for Acute Lymphocytic 

Leukemia (ALL) does not depend on age at exposure, and it does not depend on attained 

age, except during the minimum latency period (i.e., at times since exposure less than 5 

years; Land et al. 2003, Kocher et al. 2008). For exposures at ages less than 20, the risk 

has a strong dependency on time since exposure. The testing calculations for ALL 

(Table A-1) included one set of calculations for ages at exposure 20 and older (two cases 

with exposures occurring within the latency period and one case with exposures 

occurring beyond the latency period), and a second set of calculations for exposures at 

the ages less than 20, with cases being differentiated by the time elapsed until the ALL 

was diagnosed. 

By the nature of the ALL risk model, the difference between v.5.5.3 and v.5.5.3r 

depends on the magnitude of the dose. Version 5.5.3 reports a PCv.5.5.3 = ERR/(1+ERR), 

with PC being equal to 50% when ERR is equal to 1.0. In version 5.5.3r, the ERR for 

ALL in cases of acute exposures to low LET radiation is higher than the ERR in v.5.5.3 

by a factor of 1+D (where D is dose in Sv). This means that ERRv.5.5.3r = ERRv.5.5.3(1+D) 

and one can show that: 

PCv.5.5.3r = PCv.5.5.3*(1+D)/(1+ PCv.5.5.3*D) 

PCv.5.5.3r = (1+D)/(2+D) when PCv.5.5.3 = 0.5. 

The results presented in this report are for doses that would produce a PCv.5.5.3

with a 99th percentile of approximately 50%. For the most common exposure cases 

encountered among the population of nuclear workers (i.e., at ages 20 or older), v.5.5.3r 
produces a PC99 greater than that produced by v.5.5.3 by about 4 percentage points (i.e., a 

PC99 of 54% would be obtained with v.5.5.3r instead of a PC99 of 50% produced by 

v.5.5.3; Table A-1). For lower doses, the difference would be lower than 4 percentage 

points. However, for any dose, the PC99 estimated using v.5.5.3r will be larger than the 

PC99 estimated using v.5.5.3. 

In cases of exposure at ages less than 20, the PC reported by v.5.5.3r can be 

significantly higher than that reported by v.5.5.3, depending on the time elapsed between 

exposure and disease diagnosis. 

Table A-1 Average of 99th percentile PC values (%) for acute lymphocytic leukemia 

from 30 runs of 10,000 iterations each for an acute exposure to high-energy 

gamma rays. 

Age at exposure >=20 

TSE Males Females a

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

3 19 51.24 55.57 50.4 54.73 

5 16 50.56 54.26 49.67 53.38 

>=10 16 50.59 54.29 49.70 53.41 

Age at exposure < 20 

TSE Males Females 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

3 0.28 49.66 49.73 48.74 48.81 

5 0.24 49.44 49.50 48.45 48.51 

10 0.91 49.92 50.15 48.97 49.19 

20 6.5 50.17 51.75 49.24 50.82 

30 24 50.11 55.46 49.11 54.47 

40 64 49.41 61.56 48.32 60.53 

50 160 49.53 71.84 48.59 71.07 

a

 TSE = Time Since Exposure 
Issue 2: Uncertainty in the Modifier for Age Dependency for Selected Cancers

The risk models for all cancers in Group 21 have similar dependencies on age 

exposure and attained age. For a given age at diagnosis of cancer, the risk decreases with 

increasing age at exposure between the ages of 15 and 30 and is constant for ages at 

exposure greater than 30. For a given age at exposure, the risk decreases with increasing 

age at diagnosis up to age 50, after which it remains constant. The risk is reduced for 

cancers that are diagnosed during the minimum latency period of the disease. The effects 

of the reduced risk during the latency period are negligible at times greater than 15 years 

after an exposure (Land et al, 2003; Kocher et al. 2008). 

Testing calculations have been performed for colon cancer in males for a large 

number of combinations of age at exposure and attained age (age at which cancer was 

diagnosed; Table A-2). Testing runs for all Group 2 cancers were performed for a 

representative combination of ages (age 20 at time of exposure and attained age 40; 

Table A-3). 

All calculations assume an acute exposure to high energy gamma radiation. 

These assumptions were chosen to maximize the contribution of the uncertainty in the 

modifier for age dependency by eliminating additional uncertainties introduced by the 

low dose and low dose-rate effectiveness factor (DDREF) or by the relative effectiveness 

factor (REF). 

The testing results show that the PC99 reported by version v.5.5.3r is always lower 

than the PC99 obtained under the current v.5.5.3 (Table A-2 and A-3) by less than 3 

percentage points when PC99 is about 50%. (i.e., if the PC99 reported by v.5.5.3 is 50%, 

then v.5.5.3r would report a PC99 of, at most, 47%). Note that there is no difference in 

PC for exposures at ages 30 or greater or for cancers diagnosed at age 50 of greater. 

This finding affects an age modifier that applies in an identical manner to all 

cancers in Group 2. Thus, it is expected that the PC for all Group 2 cancers would be 

affected in a rather similar manner (i.e., the change in PC would be similar, but not 

exactly the same for all cancer types in this Group, because each cancer type has specific 

parameters with uncertainties that are cancer-specific). Table A-3 presents results of the 

testing exercise for all cancer types in Group 2. The results for males exposed at age 20 

 

1

 A list of Group 2 cancers is presented in Table A-3. 
and diagnosed at age 40 indicate that the PC99 estimated by v.5.5.3r is lower than the 

PC99 estimated by v.5.5.3 by about 1 percentage point (i.e., if v.5.5.3 reports a PC99 of 

50%, v.5.5.3r would report a PC99 of about 49%, with small differences between cancer 

types.) 

Table A-2 Average of 99th percentile PC values (%) for colon cancer in males from 30 

runs of 10,000 iterations each for an acute exposure to high-energy gamma 

rays. 

Time since exposure = 5 yrs 

AAEa 

(yr)

ATAb 

(yr)

Dose 

(cSv) v.5.5.3 v.5.5.3r 

18 23 45 50.62 48.87 

20 25 58 49.24 47.85 

30 35 210 49.56 49.56 

35 40 280 49.95 49.95 

>=40 >=45 330 48.59 48.59 

Time since exposure = 10 yrs 

AAE

(yr)

ATA

(yr)

Dose 

(cSv) v.5.5.3 v.5.5.3r 

18 28 12 50.56 47.96 

20 30 16 50.24 48.19 

30 40 57 50.26 50.26 

35 45 74 50.43 50.43 

>=40 >=50 89 50.24 50.24 

Time since exposure = 20 yrs 

AAE

(yr)

ATA

(yr)

Dose 

(cSv) v.5.5.3 v.5.5.3r 

18 38 24 50.41 48.79 

20 40 31 50.69 49.55 

30 50 85 50.45 50.45 

35 55 85 50.45 50.45 

>=40 >=60 85 50.45 50.45 

Time since exposure = 30 yrs 

AAE

(yr)

ATA

(yr)

Dose 

(cSv) v.5.5.3 v.5.5.3r 

18 48 37 50.32 50.07 

20 50 45 50.11 50.11 

30 60 85 50.45 50.45 

35 65 85 50.45 50.45 

>=40 >=70 85 50.45 50.45 

a

 AAE = Age at exposure 

b

 ATA = Attained age (age at which cancer was diagnosed)
Table A-3 Average of 99th percentile PC values (%) for all Group 2 cancers in males 

(ATAa

=40 yrs) from 30 runs of 10,000 iterations each for an acute exposure 

(AAEb=20 yrs) to high-energy gamma rays. 

Cancer Type Dose (cSv) v.5.5.3 v.5.5.3r 

Oral Cavity and Pharynx 76 49.79 48.88 

Esophagus 28 51.74 50.92 

Stomach 21 50.90 50.14 

Colon 31 50.69 49.55 

Rectum 83 49.77 49.03 

Gallbladder 13 51.89 51.29 

Pancreas 70 49.87 49.08 

Other respiratory 78 50.02 49.37 

Ovary (Female) 32 50.69 49.75 

All Male Genitalia 47 49.76 49.05 

Bladder 38 50.15 49.13 

Urinary organs (less bladder) 36 50.00 48.76 

Nervous system 73 49.58 48.86 

Other and ill-defined sites 39 49.40 48.36 

Lymphoma and multiple myeloma 47 49.49 48.93 

a

 ATA = Attained age (age at which cancer was diagnosed)

b

 AAE = Age at exposure 
Issue 3: Uncertainty in the Modifier for Age Dependency for the NIH Lung Model

For a given age at diagnosis of lung cancer, the NIH risk model for lung cancer 

decreases with increasing age at exposure between ages of 15 and 30 and is constant for 

older ages at exposure. For a given age at exposure, the risk predicted by the NIH model 

decreases with increasing age at diagnosis up to age 50 after which it remains constant. 

The risk is reduced for attained ages that occur during the minimum latency period of the 

disease. The effects of the reduced risk during latency period are negligible at times 

greater than 15 years after an exposure (Land et al. 2003; Kocher et al. 2008). 

The calculations comparing v.5.5.3 and v.5.5.3r are for males and are based on 

various combinations of ages at exposure and ages at diagnosis. No calculations have 

been carried out for females because v.5.5.3 and v.5.5.3r are identical (See Section 3). 

All calculations assume an acute exposure to high energy gamma radiation. This 

assumption is made to eliminate additional uncertainty introduced by the use of a low 

dose and low dose-rate effectiveness factor (DDREF) or of a relative effectiveness factor 

(REF), thus maximizing the contribution of the uncertainty in the modifier for age 

dependency to the uncertainty in PC. 

The testing results (Tables A-4, A-5 and A-6) show that, for exposures occurring 

between ages 15 and 30 and for cancers diagnosed before age 50, the PC99 calculated 

with v.5.5.3r will be ± 0.5 percentage points different than the PC99 obtained using 

v.5.5.3. (i.e., a PC99 of 50% produced by v.5.5.3 would be reported by v.5.5.3r as 

between 49.5% and 50.5%). This type of variation is much lower than the random noise 

for a NIOSH-IREP run with 2000 iterations, and is of the same magnitude with the 

random noise of a NIOSH-IREP calculation based on 30 runs of 10,000 iterations each. 

Version 5.5.3r can produce larger or lower results than v.5.5.3 depending on the 

combination of ages at exposure and at diagnosis. The differences are similar for all 

types of smoking histories (Tables A-4, A-5 and A-6). 

It is important to note that NIOSH-IREP calculates PC for lung cancer using both 

the NIH and NIOSH risk models (Kocher et al. 2008). The larger of the two PC99

estimates is used for adjudication of claims. In some cases (especially for older ages at 

exposure), the PC99 produced by the NIOSH lung model is larger than the PC99 produced 

by the NIH lung model (with either v.5.5.3 or v.5.5.3r). In these cases, the differences 

between v.5.5.3 and v.5.5.3r are irrelevant and will not affect the outcome of a claim. 
Table A-4 Average of 99th percentile PC values (%) for lung cancer in males who 

have never smoked from 30 runs of 10,000 iterations each for an acute 

exposure to high-energy gamma rays. 

Time since exposure = 5 yrs 

AAE NIH lung model NIOSH lung model a

(yr) 

ATAb

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 23 58 47.49 47.63 18.76 18.76 

20 25 76 46.85 46.98 23.23 23.23 

30 35 270 47.50 47.73 51.80 51.80 

35 40 360 47.74 47.88 58.89 58.89 

>=40 >=45 450 47.82 47.90 64.17 64.17 

Time since exposure = 10 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 28 18 49.40 49.48 27.78 27.78 

20 30 14 36.23 36.33 23.01 23.01 

30 40 80 49.10 49.38 63.10 63.10 

35 45 100 48.25 48.41 68.12 68.12 

>=40 >=50 130 50.08 50.08 73.53 73.53 

Time since exposure = 15 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 33 26 49.35 49.26 37.02 37.02 

20 35 33 48.92 48.85 42.73 42.73 

30 45 100 49.53 49.69 69.33 69.33 

35 50 140 53.17 53.17 75.99 75.99 

Time since exposure = 30 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 48 52 49.41 48.87 54.04 54.04 

20 50 76 53.98 53.46 63.21 63.21 

30 60 140 53.17 53.17 75.99 75.99 

a

 AAE = Age at exposure 

b

 ATA = Attained age 
Table A-5 Average of 99th percentile PC values (%) for lung cancer in males who 

are former smokers from 30 runs of 10,000 iterations each for an acute 

exposure to high-energy gamma rays. 

Time since exposure = 5 yrs 

AAE NIH lung model NIOSH lung model a

(yr) 

ATAb

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 23 95 47.47 47.61 13.86 13.86 

20 25 120 46.13 46.25 16.89 16.89 

30 35 420 47.58 47.71 41.57 41.57 

35 40 550 47.79 47.85 48.23 48.23 

>=40 >=45 680 47.81 47.84 53.52 53.52 

Time since exposure = 10 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 28 23 47.43 47.50 14.96 14.96 

20 30 30 47.22 47.29 18.66 18.66 

30 40 95 46.87 47.10 42.08 42.08 

35 45 120 46.64 46.75 47.85 47.85 

>=40 >=50 150 47.58 47.58 53.43 53.43 

Time since exposure = 15 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 33 32 47.41 47.34 20.49 20.49 

20 35 41 47.48 47.44 24.82 24.82 

30 45 120 48.03 48.15 49.14 49.14 

35 50 120 43.43 43.43 49.14 49.14 

Time since exposure = 30 yrs 

AAE NIH lung model NIOSH lung model 

(yr) 

ATA 

(yr) 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

18 48 63 47.53 47.10 33.66 33.66 

20 50 76 47.42 47.01 37.97 37.97 

30 60 140 47.25 47.25 52.99 52.99 

a

 AAE = Age at exposure 

b

 ATA = Attained age 
Table A-6 Average of 99th percentile PC values (%) for males with lung cancer 

(attained age = 50 yrs) from 30 runs of 10,000 iterations each for an acute 

exposure (age at exposure = 20 yrs) to high-energy gamma rays (sources 

other than radon). 

NIH lung model NIOSH lung model 

Smoking History 

Dose 

(cSv) v.5.5.3 v.5.5.3r v.5.5.3 v.5.5.3r 

Never smoked 65 50.08 49.56 59.51 59.51 

Former smoker 88 51.09 50.67 41.48 41.48 

Current smoker (? cig/day) 88 50.57 50.19 37.17 37.17 

<10 cig/day (currently) 90 51.67 51.27 42.27 42.27 

10-19 cig/day (currently) 91 51.45 51.07 38.18 38.18 

20-39 cig/day (currently) 93 51.88 51.50 38.12 38.12 

>40 cig/day (currently) 94 52.10 51.72 38.19 38.19 
This page was intentionally left blank. 
Appendix B 

General Verification Calculations 

The set of verification calculations included in this appendix is the most 

comprehensive group of deterministic calculations, covering all cancer types, both 

genders and a relevant selection of age at exposure and age at diagnosis. All thirty-two 

cancers listed in NIOSH-IREP were used in this set of verification calculations. A total of 

124 calculations were performed for this specific verification task. 

All calculations used a single acute radiation exposure to a dose of 20 cSv of high 

energy photons (E >250 keV). The radiation type was set to high energy photons (E > 

250 keV) because the radiation effectiveness factor (REF) for this radiation type is equal 

to 1.0 (i.e., no adjustments due to radiation type are needed). Similarly, we selected a 

photon dose of 20 cSv delivered acutely because for such a dose the application of a 

DDREF is not necessary. 

Further details about this verification task can be found in Section 5.1 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
This page was intentionally left blank. 

 
Verification Run Identifier 1a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Oral Cavity and Pharynx Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 182 414Original ERR/Sv 0.1720 0.6389 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.6949 1.8264 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0667 0.0590 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1051 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0855 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0480 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8765 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6833 0.6713 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.048 0.178 Excess relative risk (ERR) 

Probability of Causation (PC) 4.54 15.14 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 1b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Oral Cavity and Pharynx Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 724 1547Original ERR/Sv 0.2398 0.4691 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0894 0.0603 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2603 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1178 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9834 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1950 1.0431 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6846 0.6681 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.028 0.097 Excess relative risk (ERR) 

Probability of Causation (PC) 2.74 8.84 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 1c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Oral Cavity and Pharynx Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 7 1757

Original ERR/Sv 0.2463 0.5123 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.1156 3.0873 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0948 0.0739 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1677 1.0430 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0203 1.1100 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9851 1.0245 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0745 0.6620 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6786 0.6466 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.068 0.252 Excess relative risk (ERR) 

Probability of Causation (PC)d 6.39 20.14 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 1d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Oral Cavity and Pharynx Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 892 1045Original ERR/Sv 0.4632 0.9461 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7519 1.9970 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0668 0.0881 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1261 1.0339 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0837 1.0740 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0316 0.9609 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4194 1.0138 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5937 0.6772 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.105 0.387 Excess relative risk (ERR) 

Probability of Causation (PC)d 9.51 27.91 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 2a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Esophagus Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1194 1668Original ERR/Sv 0.1986 0.8105 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5908 1.8055 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0724 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0796 1.0239 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0354 1.2256 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0093 1.0150 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1274 0.1158 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 2.0658 2.0867 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.116 0.508 Excess relative risk (ERR) 

Probability of Causation (PC) 10.39 33.68 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 2b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Esophagus Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1020 1668Original ERR/Sv 0.3747 0.8105 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0707 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2248 1.0239 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1026 1.2256 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0391 1.0150 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7945 0.1158 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 2.0366 2.0867 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.069 0.281 Excess relative risk (ERR) 

Probability of Causation (PC) 6.49 21.95 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 2c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Esophagus Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 959 58Original ERR/Sv 0.2713 0.8702 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.4591 3.2385 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0799 0.0982 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1016 1.1577 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0801 1.0775 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9761 0.9598 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6444 0.6741 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.9778 2.1842 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.167 0.717 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.33 41.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 2d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Esophagus Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1117 414Original ERR/Sv 0.5991 2.4857 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.8300 1.8264 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0821 0.0766 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2331 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1685 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9132 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1774 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0923 1.0099 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.194 0.834 Excess relative risk (ERR) 

Probability of Causation (PC)d 16.25 45.49 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 3a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Stomach Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1839 1323Original ERR/Sv 0.1193 0.1893 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.2035 2.5461 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0963 0.0788 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0828 1.0635 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0754 1.1684 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0105 1.0115 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7956 0.1807 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 9.2761 9.1963 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.072 0.638 Excess relative risk (ERR) 

Probability of Causation (PC) 6.72 38.96 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 3b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Stomach Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1799 503Original ERR/Sv 0.0384 0.2304 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0809 0.1117 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1991 1.2575 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2623 1.1360 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0539 0.9562 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1373 0.0355 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 9.2270 9.5359 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.042 0.346 Excess relative risk (ERR) 

Probability of Causation (PC) 4.04 25.72 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 3c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Stomach Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 277 1932Original ERR/Sv 0.1452 0.2078 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.1086 2.8966 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0667 0.0602 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0719 1.1305 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1461 1.0579 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9968 1.0248 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8836 0.0839 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 9.1930 9.4945 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.104 0.914 Excess relative risk (ERR) 

Probability of Causation (PC)d 9.44 47.76 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 3d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Stomach Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 191 1668Original ERR/Sv 0.5900 1.1958 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3985 1.8055 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1104 0.0917 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1510 1.0239 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1756 1.2256 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9467 1.0150 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6383 0.1158 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 9.0052 8.9963 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.557 2.987 Excess relative risk (ERR) 

Probability of Causation (PC)d 35.78 74.92 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 4a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1200 329Original ERR/Sv 0.5300 1.5885 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7197 1.6400 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0917 0.0927 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2057 1.1850 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1065 1.1734 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9706 0.9848 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4931 0.3925 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0590 1.1286 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.158 0.448 Excess relative risk (ERR) 

Probability of Causation (PC) 13.67 30.95 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 4b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 854 729Original ERR/Sv 0.5317 1.2115 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0876 0.0590 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1403 1.0756 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0903 1.1048 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0164 0.9889 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7164 0.1081 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0888 1.0966 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.094 0.237 Excess relative risk (ERR) 

Probability of Causation (PC) 8.58 19.17 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 4c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 696

Original ERR/Sv 0.3770 1.0795 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.1638 3.0345 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0940 0.1031 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0880 1.1456 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1132 1.0861 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0640 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9232 -0.0929 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1143 1.1538 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.229 0.638 Excess relative risk (ERR) 

Probability of Causation (PC)d 18.61 38.93 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 4d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 160 1692Original ERR/Sv 0.5911 1.0607 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7050 2.6694 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1006 0.0731 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1795 1.1752 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1422 1.1113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9768 1.0247 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8726 0.8033 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8206 0.8488 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.165 0.441 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.14 30.59 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 5a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Rectum Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 186 1393Original ERR/Sv 0.0674 0.4494 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7576 2.1290 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1045 0.0700 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1819 1.2436 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0947 1.2485 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0468 0.9614 multiplicative risk model 

 Model Mixture factor for transfer to US pop -0.0071 0.5701 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.4467 1.4329 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.028 0.163 Excess relative risk (ERR) 

Probability of Causation (PC) 2.72 13.99 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 5b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Rectum Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1181 110Original ERR/Sv 0.0874 0.4291 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0794 0.0818 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1419 1.1075 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1294 1.1916 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9901 1.0102 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7434 0.4145 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.5142 1.4542 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.017 0.088 Excess relative risk (ERR) 

Probability of Causation (PC) 1.65 8.10 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 5c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Rectum Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1338 1393Original ERR/Sv 0.0751 0.4494 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3367 3.0109 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0721 0.0700 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2607 1.2436 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1352 1.2485 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0063 0.9614 multiplicative risk model 

 Model Mixture factor for transfer to US pop -0.0660 0.5701 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.5137 1.4329 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.040 0.230 Excess relative risk (ERR) 

Probability of Causation (PC)d 3.89 18.70 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 5d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Rectum Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 747 912Original ERR/Sv 0.1443 0.7787 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0040 2.1505 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1183 0.0874 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1392 1.0955 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1485 1.1504 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0134 1.0100 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3512 0.4920 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.3400 1.3637 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.060 0.339 Excess relative risk (ERR) 

Probability of Causation (PC)d 5.62 25.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 6a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer All digestive Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 289 512Original ERR/Sv 0.2382 0.5301 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0836 0.0825 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1331 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1915 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9795 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1395 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 2.8432 2.7818 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.101 0.255 Excess relative risk (ERR) 

Probability of Causation (PC) 9.17 20.30 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 6b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer All digestive Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1655 512Original ERR/Sv 0.1887 0.3321 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0564 0.0825 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2971 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2693 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0321 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0740 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 2.8082 2.7818 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.063 0.160 Excess relative risk (ERR) 

Probability of Causation (PC) 5.90 13.76 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 6c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer All digestive Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 839 512Original ERR/Sv 0.5774 0.7683 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0855 0.0825 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2640 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2479 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9754 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5663 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 2.8035 2.7818 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.145 0.369 Excess relative risk (ERR) 

Probability of Causation (PC)d 12.68 26.96 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 6d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer All digestive Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 684 245Original ERR/Sv 0.6698 1.0904 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0896 0.0717 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1843 1.0926 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1767 1.2530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0769 0.9201 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2731 0.1532 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.9286 1.8995 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.163 0.327 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.01 24.63 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 7a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Liver Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1742 512Original ERR/Sv 0.5829 1.0682 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0716 0.0669 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2438 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1077 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9751 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5283 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 8.5053 8.3881 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.422 1.534 Excess relative risk (ERR) 

Probability of Causation (PC) 29.68 60.53 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 7b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Liver Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1556 512Original ERR/Sv 0.3739 0.6505 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0692 0.0669 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2354 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1470 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0021 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5267 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 8.3211 8.3881 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.251 0.934 Excess relative risk (ERR) 

Probability of Causation (PC) 20.09 48.30 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 7c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Liver Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1556 512Original ERR/Sv 0.8948 1.5531 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0692 0.0669 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2354 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1470 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0021 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5267 -0.0226 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 8.3211 8.3881 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.602 2.230 Excess relative risk (ERR) 

Probability of Causation (PC)d 37.56 69.04 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 7d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Liver Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 689 512Original ERR/Sv 0.7312 1.0682 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0881 0.0669 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0640 1.0835 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1016 1.2113 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9635 0.9687 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7533 -0.0226 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 5.6778 5.7787 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.304 1.055 Excess relative risk (ERR) 

Probability of Causation (PC)d 23.29 51.35 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 8a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Gallbladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 210 245Original ERR/Sv 0.1239 0.3551 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3258 1.7081 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0692 0.0705 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1832 1.0926 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2179 1.2530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9737 0.9201 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7373 0.1532 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 12.4170 12.6065 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.100 1.116 Excess relative risk (ERR) 

Probability of Causation (PC) 9.10 52.75 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 8b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Gallbladder Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 732 982Original ERR/Sv 0.0344 0.2962 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1512 0.1187 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0596 1.1383 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2799 1.0913 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0272 1.0339 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1884 -0.0164 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 13.3166 11.7879 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.062 0.617 Excess relative risk (ERR) 

Probability of Causation (PC) 5.88 38.17 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 8c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Gallbladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1020 1668Original ERR/Sv 0.1120 0.3136 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3559 2.5833 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1116 0.0998 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2248 1.0239 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1026 1.2256 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0391 1.0150 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7945 0.1158 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 13.0722 12.5374 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.145 1.567 Excess relative risk (ERR) 

Probability of Causation (PC)d 12.70 61.05 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 8d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Gallbladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 611 245Original ERR/Sv 0.3473 0.7848 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0655 1.7081 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0811 0.0705 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1238 1.0926 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0588 1.2530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9736 0.9201 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8044 0.1532 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 6.5015 6.2619 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.143 1.243 Excess relative risk (ERR) 

Probability of Causation (PC)d 12.54 55.42 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 9a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Pancreas Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1412 679Original ERR/Sv 0.1563 0.5658 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3896 2.0544 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0954 0.0789 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3309 1.1779 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0983 1.2094 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0173 1.0298 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2995 0.3402 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.2098 1.2347 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.037 0.197 Excess relative risk (ERR) 

Probability of Causation (PC) 3.54 16.49 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 9b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Pancreas Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1625 863Original ERR/Sv 0.1443 0.4974 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1037 0.0866 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3737 1.1717 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1127 1.0944 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9683 0.9488 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8902 0.1230 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1395 1.2015 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.022 0.105 Excess relative risk (ERR) 

Probability of Causation (PC) 2.14 9.46 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 9c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Pancreas Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 733 679Original ERR/Sv 0.1158 0.5658 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5397 2.9127 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0881 0.0789 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1592 1.1779 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1055 1.2094 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0308 1.0298 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3743 0.3402 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1606 1.2347 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.053 0.280 Excess relative risk (ERR) 

Probability of Causation (PC)d 5.06 21.87 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 9d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Pancreas Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 576 1151Original ERR/Sv 0.3064 1.2042 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5717 1.9296 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1081 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0919 1.1396 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1260 1.2304 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0812 0.9320 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3721 0.1032 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9333 0.9660 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.077 0.373 Excess relative risk (ERR) 

Probability of Causation (PC)d 7.14 27.17 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 10a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 720 1305Original ERR/Sv 0.6477 0.7451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1168 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0722 1.1818 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1975 1.0316 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0342 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1956 0.7841 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7358 0.7121 Smoking history 1.475203 3.548618 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.127 0.465 Excess relative risk (ERR) 

Probability of Causation (PC) 11.24 31.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 10b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 720 1305Original ERR/Sv 0.6477 0.7451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1168 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0722 1.1818 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1975 1.0316 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0342 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1956 0.7841 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7358 0.7121 Smoking history 1.475203 3.548618 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.127 0.465 Excess relative risk (ERR) 

Probability of Causation (PC) 11.24 31.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 10c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 720 1305Original ERR/Sv 0.6477 0.7451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1168 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0722 1.1818 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1975 1.0316 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0342 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1956 0.7841 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7358 0.7121 Smoking history 1.475203 3.548618 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.127 0.465 Excess relative risk (ERR) 

Probability of Causation (PC)d 11.24 31.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 10d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 485 132Original ERR/Sv 1.6814 2.7666 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0923 0.0715 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1067 1.0356 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1249 1.1335 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9881 0.9714 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5503 1.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3777 0.3659 Smoking history 1.710404 2.426341 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.368 1.276 Excess relative risk (ERR) 

Probability of Causation (PC)d 26.89 56.07 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 11a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other respiratory Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 449 124Original ERR/Sv 0.0617 0.7551 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5143 1.5553 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1048 0.0614 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1937 1.1452 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0650 1.1605 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9391 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3303 0.1378 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9135 0.8934 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.016 0.178 Excess relative risk (ERR) 

Probability of Causation (PC) 1.60 15.10 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 11b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other respiratory Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 22 932Original ERR/Sv 0.0704 0.5523 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0906 0.1103 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2297 1.0932 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1052 1.1202 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9885 1.0206 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0245 0.8413 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8380 1.0377 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.010 0.099 Excess relative risk (ERR) 

Probability of Causation (PC) 0.95 8.98 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 11c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Other respiratory Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1040 11

Original ERR/Sv 0.0751 0.6175 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.8424 2.6641 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1123 0.0920 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1925 1.2804 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1266 1.0432 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9632 0.9935 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7043 0.0553 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9528 0.9342 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.023 0.254 Excess relative risk (ERR) 

Probability of Causation (PC)d 2.29 20.25 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 11d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other respiratory Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 417 389Original ERR/Sv 0.1369 1.2603 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3803 1.6294 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1303 0.0857 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0695 1.0389 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0948 1.0720 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9209 1.0083 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5965 0.8781 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6923 0.7453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.035 0.385 Excess relative risk (ERR) 

Probability of Causation (PC)d 3.35 27.79 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 12a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bone Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 755 414Original ERR/Sv 0.7010 1.2648 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3359 1.8264 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0707 0.1039 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0985 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1960 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0860 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7797 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6943 0.6579 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.131 0.365 Excess relative risk (ERR) 

Probability of Causation (PC) 11.59 26.76 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 12b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bone Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 913 859Original ERR/Sv 0.5431 1.5814 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0739 0.0772 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1857 1.2002 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1532 1.2142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9940 1.0619 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6334 0.7071 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7346 0.6862 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.077 0.200 Excess relative risk (ERR) 

Probability of Causation (PC) 7.19 16.66 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 12c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Bone Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 210 1024Original ERR/Sv 0.6933 0.9663 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.9387 2.8054 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0727 0.1155 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1832 1.0414 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2179 1.1006 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9737 0.9584 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7373 0.8528 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6935 0.5592 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.189 0.515 Excess relative risk (ERR) 

Probability of Causation (PC)d 15.89 33.99 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 12d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bone Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1359 1236Original ERR/Sv 0.9597 1.9063 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7666 2.1927 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0908 0.1548 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0541 1.0517 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0770 1.0921 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0113 0.9735 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9348 0.7621 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8333 0.5817 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.319 0.778 Excess relative risk (ERR) 

Probability of Causation (PC)d 24.16 43.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 13a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Connective tissue Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 140 1609Original ERR/Sv 0.6082 1.1323 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4605 2.0878 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0907 0.0674 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2968 1.2678 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1011 1.2567 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9166 0.9050 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6730 0.9953 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3985 0.4967 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.119 0.349 Excess relative risk (ERR) 

Probability of Causation (PC) 10.63 25.88 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 13b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Connective tissue Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 558 1149Original ERR/Sv 0.7858 1.0882 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1066 0.0726 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2018 1.1357 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1199 1.0782 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9459 1.0024 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1147 1.0293 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4535 0.3993 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.071 0.194 Excess relative risk (ERR) 

Probability of Causation (PC) 6.59 16.22 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 13c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Connective tissue Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 181 1547Original ERR/Sv 0.3393 1.0065 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.3005 2.3518 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0779 0.0730 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1616 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1517 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9763 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8660 1.0431 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4360 0.5664 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.171 0.497 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.60 33.22 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 13d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Connective tissue Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 210 1024Original ERR/Sv 1.5256 2.0368 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.3258 1.9731 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0710 0.0776 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1832 1.0414 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2179 1.1006 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9737 0.9584 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7373 0.8528 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6903 0.7443 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.284 0.759 Excess relative risk (ERR) 

Probability of Causation (PC)d 22.10 43.15 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 14a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Malignant melanoma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 423 1325Original ERR/Sv 4.3731 16.1408 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0727 0.0817 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0643 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1357 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0143 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6251 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0328 0.0382 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.488 2.488 Excess relative risk (ERR) 

Probability of Causation (PC) 32.79 71.33 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 14b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Malignant melanoma Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1410 1945Original ERR/Sv 0.5092 1.5355 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0852 0.1072 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1293 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1194 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0698 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3309 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0352 0.0349 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.029 0.235 Excess relative risk (ERR) 

Probability of Causation (PC) 2.82 19.01 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 14c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 423 1325Original ERR/Sv 4.3731 16.1408 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0727 0.0817 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0643 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1357 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0143 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6251 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0328 0.0382 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.488 2.488 Excess relative risk (ERR) 

Probability of Causation (PC)d 32.79 71.33 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 14d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Malignant melanoma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 423 1325Original ERR/Sv 4.3731 16.1408 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0727 0.0817 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0643 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1357 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0143 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6251 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0403 0.0468 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.490 2.494 Excess relative risk (ERR) 

Probability of Causation (PC)d 32.88 71.38 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 15a

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1914 1430Original ERR/Sv 6.5787 13.4140 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0754 0.0587 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2660 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1412 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0565 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5124 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0205 0.0267 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.484 2.510 Excess relative risk (ERR) 

Probability of Causation (PC) 32.63 71.51 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 15b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1417 1430Original ERR/Sv 0.7437 1.2386 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0917 0.0587 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1690 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1624 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9814 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2214 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0171 0.0203 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.029 0.232 Excess relative risk (ERR) 

Probability of Causation (PC) 2.78 18.82 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 15c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 15 1430

Original ERR/Sv 4.5614 13.4140 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0853 0.0587 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1193 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2012 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9865 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6356 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0215 0.0203 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.480 2.511 Excess relative risk (ERR) 

Probability of Causation (PC)d 32.45 71.52 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 15d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1914 1430Original ERR/Sv 6.5787 13.4140 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0754 0.0587 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2660 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1412 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0565 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5124 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0205 0.0267 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.484 2.510 Excess relative risk (ERR) 

Probability of Causation (PC)d 32.63 71.51 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 16a

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 1945

Original ERR/Sv -0.1915 0.4633 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0250 0.0280 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.069 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 6.46 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 16b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 1945

Original ERR/Sv -0.1915 0.4633 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0189 0.0213 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.069 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 6.45 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 16c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 1945

Original ERR/Sv -0.1915 0.4633 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0189 0.0213 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.069 Excess relative risk (ERR) 

Probability of Causation (PC)d 0.00 6.45 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 16d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 1945

Original ERR/Sv -0.1915 0.4633 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0250 0.0280 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.069 Excess relative risk (ERR) 

Probability of Causation (PC)d 0.00 6.46 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 17a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer All Male Genitalia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1497 1325Original ERR/Sv 0.2753 1.0849 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4422 1.7256 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0843 0.0942 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2382 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0570 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0253 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5762 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0953 0.1002 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.040 0.297 Excess relative risk (ERR) 

Probability of Causation (PC) 3.81 22.91 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 17b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer All Male Genitalia Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 513 1882Original ERR/Sv 0.3645 1.0597 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0720 0.0965 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2243 1.0399 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0799 1.1746 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0029 1.0319 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3386 0.9062 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.1010 0.1020 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.024 0.169 Excess relative risk (ERR) 

Probability of Causation (PC) 2.33 14.45 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 17c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer All Male Genitalia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1026 1325Original ERR/Sv 0.2841 1.0849 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0477 2.4768 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0751 0.0942 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1036 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2473 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0631 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6295 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.1076 0.1002 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.057 0.427 Excess relative risk (ERR) 

Probability of Causation (PC)d 5.41 29.90 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 18a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1413 1281Original ERR/Sv 0.7343 1.3384 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7841 1.9233 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0707 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3323 1.2567 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1227 1.0711 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0214 1.0244 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1593 0.7846 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5645 0.5726 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.117 0.363 Excess relative risk (ERR) 

Probability of Causation (PC) 10.46 26.63 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 18b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bladder Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 722 1149Original ERR/Sv 0.5181 1.1115 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0735 0.0977 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1079 1.1357 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1788 1.0782 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9810 1.0024 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5531 1.0293 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5382 0.5447 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.069 0.201 Excess relative risk (ERR) 

Probability of Causation (PC) 6.45 16.77 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 18c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Bladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 242 1281Original ERR/Sv 0.4724 1.3384 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5364 2.7396 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1193 0.0707 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1372 1.2567 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0675 1.0711 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0474 1.0244 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5173 0.7846 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5817 0.5726 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.168 0.517 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.41 34.08 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 18d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Bladder Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1505 1547Original ERR/Sv 1.8734 2.4374 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.6003 1.6321 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0856 0.0906 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0729 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1976 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0104 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0630 1.0431 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4754 0.5091 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.255 0.852 Excess relative risk (ERR) 

Probability of Causation (PC)d 20.31 45.99 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 19a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Urinary organs (less bladder) Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 100 1325Original ERR/Sv 0.6526 1.1939 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5813 1.7256 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0969 0.0823 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0752 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0854 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0828 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4937 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6981 0.7105 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.152 0.380 Excess relative risk (ERR) 

Probability of Causation (PC) 13.18 27.52 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 19b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Urinary organs (less bladder) Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1488 1010Original ERR/Sv 0.7323 1.4363 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0847 0.0812 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3354 1.2956 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0897 1.1297 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0538 1.0430 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6554 0.9524 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6305 0.7050 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.090 0.201 Excess relative risk (ERR) 

Probability of Causation (PC) 8.29 16.71 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 19c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Urinary organs (less bladder) Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 544 414Original ERR/Sv 0.4660 1.2791 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.9470 2.6110 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.1041 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1012 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1161 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9331 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5245 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6830 0.6923 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.219 0.538 Excess relative risk (ERR) 

Probability of Causation (PC)d 17.94 35.00 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 19d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Urinary organs (less bladder) Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 390 1236Original ERR/Sv 1.3552 2.2882 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5278 2.1927 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0651 0.0901 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0819 1.0517 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0743 1.0921 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9800 0.9735 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6812 0.7621 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5861 0.5579 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.336 0.876 Excess relative risk (ERR) 

Probability of Causation (PC)d 25.16 46.68 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 20a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Eye Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1031 1430Original ERR/Sv 0.7899 1.0247 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.8931 1.8462 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0885 0.0725 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1316 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2026 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9919 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0734 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4642 0.3886 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.121 0.353 Excess relative risk (ERR) 

Probability of Causation (PC) 10.83 26.08 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 20b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Eye Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 682 1820Original ERR/Sv 0.4674 1.0233 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1237 0.0918 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1582 1.0999 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1570 1.0686 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0564 0.9730 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9337 0.9969 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5867 0.2938 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.072 0.195 Excess relative risk (ERR) 

Probability of Causation (PC) 6.73 16.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 20c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Eye Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 485 1430Original ERR/Sv 0.4419 1.0247 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8192 2.6373 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0967 0.0725 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1067 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1249 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9881 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5503 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5281 0.3886 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.175 0.504 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.89 33.51 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 20d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Eye Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 172 1325Original ERR/Sv 1.0400 2.3951 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7185 1.7256 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0844 0.1053 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2903 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1563 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9163 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6218 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3669 0.3073 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.216 0.702 Excess relative risk (ERR) 

Probability of Causation (PC)d 17.74 41.24 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 21a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Nervous system Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 331 414Original ERR/Sv 0.1940 0.7418 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0229 1.8264 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1258 0.0804 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3836 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0678 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0601 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4106 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4240 0.4412 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.037 0.185 Excess relative risk (ERR) 

Probability of Causation (PC) 3.59 15.62 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 21b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Nervous system Attained age 

Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 361 132Original ERR/Sv 0.1962 0.5503 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0561 0.0801 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1860 1.0356 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1295 1.1335 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9725 0.9714 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4376 1.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4641 0.3512 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.022 0.106 Excess relative risk (ERR) 

Probability of Causation (PC) 2.17 9.54 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 21c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Nervous system Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 350 177Original ERR/Sv 0.1593 0.9189 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8914 3.3756 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0964 0.0893 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0859 1.1944 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2557 1.0927 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9551 1.0625 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5228 0.2704 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3473 0.3641 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.053 0.261 Excess relative risk (ERR) 

Probability of Causation (PC)d 5.07 20.71 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 21d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Nervous system Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 881 409Original ERR/Sv 0.4835 1.3278 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7450 1.8890 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0899 0.0692 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0432 1.1418 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1979 1.1142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0847 1.0277 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4519 1.0549 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4222 0.5498 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.093 0.420 Excess relative risk (ERR) 

Probability of Causation (PC)d 8.48 29.60 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 22a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other endocrine Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1002 679Original ERR/Sv 0.5188 1.2902 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4669 2.0544 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1110 0.1080 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1488 1.1779 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1141 1.2094 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9143 1.0298 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9876 0.3402 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9123 0.9700 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.144 0.393 Excess relative risk (ERR) 

Probability of Causation (PC) 12.61 28.19 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 22b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other endocrine Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 327 1281Original ERR/Sv 0.5537 1.2840 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0975 0.1074 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2402 1.2567 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0337 1.0711 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0196 1.0244 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4640 0.7846 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8607 1.0619 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.086 0.209 Excess relative risk (ERR) 

Probability of Causation (PC) 7.92 17.29 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 22c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Other endocrine Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 611 679Original ERR/Sv 0.7476 1.2902 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5823 2.9127 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0735 0.1080 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1238 1.1779 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0588 1.2094 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9736 1.0298 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8044 0.3402 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7242 0.9700 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.207 0.556 Excess relative risk (ERR) 

Probability of Causation (PC)d 17.18 35.75 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 22d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other endocrine Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1343 695Original ERR/Sv 1.2543 2.8296 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.5962 1.6881 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0892 0.0670 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2257 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1151 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9845 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3831 0.4442 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0098 1.1029 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.326 0.819 Excess relative risk (ERR) 

Probability of Causation (PC)d 24.59 45.03 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 23a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other and ill-defined sites Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 491 1547Original ERR/Sv 0.4832 1.0065 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4632 1.6321 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0933 0.0721 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0938 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2209 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0260 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9909 1.0431 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4764 0.4518 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.112 0.347 Excess relative risk (ERR) 

Probability of Causation (PC) 10.10 25.74 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 23b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other and ill-defined sites Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1678 409Original ERR/Sv 0.4124 1.0992 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0928 0.1093 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0095 1.1418 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0844 1.1142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0163 1.0277 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7049 1.0549 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4243 0.4359 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.067 0.192 Excess relative risk (ERR) 

Probability of Causation (PC) 6.30 16.13 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 23c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Other and ill-define Attained age 

Exposure Information

 Exposure year 1920 Exposure rate acute

 Radiation type photons E>250

Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 46 1547

Original ERR/Sv 0.4368 1.0065 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.4084 2.3518 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0773 0.0721 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1142 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1550 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0416 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9315 1.0430 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3472 0.4518 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.162 0.499 Excess relative risk (ERR) 

Probability of Causation (PC)d 13.91 33.30 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 23d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Other and ill-defined sites Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1303 1547Original ERR/Sv 1.3118 2.1087 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2353 1.6321 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1128 0.0721 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0753 1.0530 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1047 1.0267 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0651 0.9623 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2220 1.0431 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3031 0.3986 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.236 0.728 Excess relative risk (ERR) 

Probability of Causation (PC)d 19.10 42.12 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 24a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lymphoma and multiple myeloma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 216 1609Original ERR/Sv 0.1690 0.8990 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.2410 2.0878 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1055 0.1058 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1468 1.2678 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0611 1.2567 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0656 0.9050 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0349 0.9953 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5328 0.5399 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.036 0.287 Excess relative risk (ERR) 

Probability of Causation (PC) 3.51 22.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 24b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lymphoma and multip Attained age 

Exposure Information Exposure year 1940 Exposure rate acute

 Radiation type photons E>250

Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 628 875Original ERR/Sv 0.1676 1.1222 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0822 0.0936 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1640 1.1572 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0924 1.2019 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0586 0.9374 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5740 0.7159 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5433 0.5095 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.022 0.162 Excess relative risk (ERR) 

Probability of Causation (PC) 2.12 13.94 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 24c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lymphoma and multiple myeloma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 501 1325Original ERR/Sv 0.1527 0.9565 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2048 2.4768 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0913 0.0660 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1283 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0970 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9153 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6026 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5202 0.5344 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.052 0.412 Excess relative risk (ERR) 

Probability of Causation (PC)d 4.99 29.16 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 24d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lymphoma and multiple myeloma Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 881 859Original ERR/Sv 0.1841 1.7579 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7450 1.3331 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0779 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0432 1.2002 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1979 1.2142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0847 1.0619 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4519 0.7071 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.4068 0.4814 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.034 0.280 Excess relative risk (ERR) 

Probability of Causation (PC)d 3.33 21.87 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 25a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC) 26.50 71.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 25b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1960 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 0.1507 2.9477 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.030 0.590 Excess relative risk (ERR) 

Probability of Causation (PC) 2.93 37.09 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 25c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC)d 26.50 71.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 25d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.1314 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC)d 26.50 71.32 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 26a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1292 1411Original ERR/Sv 0.0682 0.4845 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0585 0.0464 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0766 1.1861 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1155 1.1347 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0152 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4046 -0.0212 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9107 0.8271 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.013 0.076 Excess relative risk (ERR) 

Probability of Causation (PC) 1.33 7.05 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 26b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1960 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 56 257Original ERR/Sv 2.1359 4.5382 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0502 0.0752 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1565 1.0813 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0837 1.0673 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0137 0.9347 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9343 0.0878 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8379 0.8171 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.419 0.905 Excess relative risk (ERR) 

Probability of Causation (PC) 29.54 47.49 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 26c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1077 1978Original ERR/Sv 3.3058 5.0967 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0709 0.0352 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1105 1.0251 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1839 1.0784 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9956 0.9682 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2170 0.8836 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9630 0.8981 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.630 1.169 Excess relative risk (ERR) 

Probability of Causation (PC)d 38.66 53.90 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 26d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 601 1391Original ERR/Sv 0.0635 0.4963 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0564 0.0458 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0859 1.2755 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1694 1.1278 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0224 1.0034 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8149 0.1180 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6654 0.7314 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.012 0.066 Excess relative risk (ERR) 

Probability of Causation (PC)d 1.15 6.18 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 27a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Lymphocytic Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1555 414Original ERR/Sv 1.7769 8.2421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0516 0.0431 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0581 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2187 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9199 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7659 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7782 0.7352 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.358 1.541 Excess relative risk (ERR) 

Probability of Causation (PC) 26.39 60.64 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 27b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Lymphocytic Leukemia Attained age Exposure Information Exposure year 1960 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1555 414Original ERR/Sv 1.7769 8.2421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0516 0.0431 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0581 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2187 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9199 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7659 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7782 0.7352 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.358 1.541 Excess relative risk (ERR) 

Probability of Causation (PC) 26.39 60.64 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 27c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Acute Lymphocytic Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1555 414Original ERR/Sv 1.7769 8.2421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0516 0.0431 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0581 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2187 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9199 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7659 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7782 0.7352 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.358 1.541 Excess relative risk (ERR) 

Probability of Causation (PC)d 26.39 60.64 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 27d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Lymphocytic Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 521 1391Original ERR/Sv 2.4867 10.3334 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0419 0.0527 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3119 1.2077 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1707 1.2119 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0465 1.0791 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5432 0.5366 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7653 0.7810 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.345 1.485 Excess relative risk (ERR) 

Probability of Causation (PC)d 25.67 59.76 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 28a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Myeloid Leukemia Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 56 684Original ERR/Sv 0.4817 2.8327 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0620 0.0588 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1565 1.2257 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0837 1.2060 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0137 0.9766 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9343 0.3980 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7789 0.8536 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.095 0.455 Excess relative risk (ERR) 

Probability of Causation (PC) 8.70 31.26 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 28b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Myeloid Leukemia Attained age 

Exposure Information Exposure year 1960 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 676 248Original ERR/Sv 3.2358 5.7979 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0693 0.0577 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1937 1.1441 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0738 1.2209 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0744 0.9765 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5558 0.9777 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7978 0.8033 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.549 1.074 Excess relative risk (ERR) 

Probability of Causation (PC) 35.44 51.79 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 28c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Acute Myeloid Leukemia Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 676 248Original ERR/Sv 3.2358 5.7979 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0693 0.0577 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1937 1.1441 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0738 1.2209 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0744 0.9765 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5558 0.9777 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7978 0.8033 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.549 1.074 Excess relative risk (ERR) 

Probability of Causation (PC)d 35.44 51.79 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 28d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Acute Myeloid Leukemia Attained age 

Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 372 1307Original ERR/Sv 0.5266 2.9806 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0396 0.0557 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1178 1.2421 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1356 1.1551 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0617 0.9937 multiplicative risk model 

 Model Mixture factor for transfer to US pop -0.0255 0.1235 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9628 0.8255 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.094 0.449 Excess relative risk (ERR) 

Probability of Causation (PC)d 8.57 30.97 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 29a

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Chronic Myeloid Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 505 1411Original ERR/Sv 0.0005 0.2848 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0389 0.0624 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1584 1.1861 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0952 1.1347 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9712 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5800 -0.0212 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6152 0.5624 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.030 Excess relative risk (ERR) 

Probability of Causation (PC) 0.01 2.95 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 29b

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Chronic Myeloid Leukemia Attained age Exposure Information Exposure year 1960 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 526 348Original ERR/Sv 1.0528 5.3493 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0665 0.0567 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2091 1.2519 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1359 1.1314 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0345 1.0526 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1972 0.9551 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6686 0.6749 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.139 0.897 Excess relative risk (ERR) 

Probability of Causation (PC) 12.22 47.27 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 29c

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Chronic Myeloid Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 526 348Original ERR/Sv 1.0528 5.3493 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0665 0.0567 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2091 1.2519 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1359 1.1314 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0345 1.0526 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1972 0.9551 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6686 0.6749 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.139 0.897 Excess relative risk (ERR) 

Probability of Causation (PC)d 12.22 47.27 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 29d

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Chronic Myeloid Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 378 1411Original ERR/Sv 1.1557 15.8844 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0527 0.0624 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2352 1.1861 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0629 1.1347 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0093 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5096 -0.0212 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7747 0.6760 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.196 2.052 Excess relative risk (ERR) 

Probability of Causation (PC)d 16.39 67.24 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 30a

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 507 1010Original ERR/Sv 1.1868 2.4979 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0949 0.0689 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1618 1.2956 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1715 1.1297 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0239 1.0430 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3193 0.9524 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3371 0.3343 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.102 0.339 Excess relative risk (ERR) 

Probability of Causation (PC) 9.28 25.30 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 30b

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 757 6

Original ERR/Sv 1.1446 1.3419 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0742 0.1071 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1045 1.1609 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1438 1.0821 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9289 1.0038 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0587 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3407 0.3385 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.071 0.245 Excess relative risk (ERR) 

Probability of Causation (PC) 6.66 19.66 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 30c

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 558 6

Original ERR/Sv 2.7245 2.9301 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0966 0.1071 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2018 1.1609 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1199 1.0821 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9459 1.0038 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0587 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3413 0.3385 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.160 0.534 Excess relative risk (ERR) 

Probability of Causation (PC)d 13.81 34.83 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 31a

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Ovary Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 527 1430Original ERR/Sv 0.4168 1.2624 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.9531 1.8462 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0806 0.0811 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0394 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1236 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9616 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4139 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5859 0.5244 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.119 0.435 Excess relative risk (ERR) 

Probability of Causation (PC) 10.61 30.33 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 31b

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Ovary Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1269 487Original ERR/Sv 0.6704 1.4172 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1353 0.0920 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0749 1.1482 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1567 1.1481 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0653 0.9920 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2104 1.0804 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5147 0.4955 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.071 0.246 Excess relative risk (ERR) 

Probability of Causation (PC) 6.62 19.76 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 31c

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Ovary Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 824 1430Original ERR/Sv 0.6518 1.2624 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0613 2.6373 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1058 0.0811 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1978 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0171 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9984 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3600 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5331 0.5244 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.171 0.622 Excess relative risk (ERR) 

Probability of Causation (PC)d 14.62 38.35 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 32a

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Female Genitalia (less ovary) Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 414

Original ERR/Sv -0.2391 0.0858 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0841 0.0963 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6401 0.6730 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 1.34 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 32b

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Female Genitalia (less ovary) Attained age Exposure Information Exposure year 1940 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 414

Original ERR/Sv -0.2391 0.0858 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0841 0.0963 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6401 0.6730 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 1.34 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier 32c

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Female Genitalia (less ovary) Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 414

Original ERR/Sv -0.2391 0.0858 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0841 0.0963 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1584 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1204 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9067 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.5421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6401 0.6730 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREPd Final results calculated in Excel

Excess relative risk (ERR) 0.000 0.014 Excess relative risk (ERR) 

Probability of Causation (PC)d 0.00 1.34 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Refers to errors in doses assigned to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix C 

Verification of the Implementation of the Minimum Latency Period for Leukemia, 

Thyroid, and Solid Tumor Cancers 

The set of calculations documented in this appendix was performed to verify that 

the algorithms describing the minimum latency period have been implemented correctly. 

A series of 30 calculations was performed for this specific verification task. 

Calculations were completed for leukemia (representative of all types of 

leukemia), thyroid (also representative of bone cancer), and colon (representative of all 

other solid tumors) because the minimum latency adjustment is different for each of these 

three groupings of cancer. 

Calculations were performed for males and females receiving an acute dose of 

20 cSv from high energy photons, E > 250 keV. The assumption of an acute exposure to 

high energy photons causes the radiation effectiveness factor (REF) and the dose and 

dose rate effectiveness factor (DDREF) to be equal to 1.0. It should also be noted that 

the level of dose does not affect the minimum latency period adjustment. 

Because the latency adjustment is independent of age at time of exposure (AAE), 

the AAE was kept constant at 20 years. Five different scenarios were considered related 

to the number of years after exposure that the cancer was diagnosed. The times since 

exposure (TSE) used for these calculations are 2, 3, 5, 10, and 15 years. 

Further details about this verification task can be found in Section 5.2 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

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Verification Run Identifier latency_leu_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 3 1237

Original ERR/Sv 19.7233 52.3505 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.3715 0.3832 w/ latency adjustment 

 Random errors in dosesb 0.0685 0.0504 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1069 1.0519 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0720 1.1956 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0378 0.9728 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8099 0.6328 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9068 0.9498 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.499 4.057 Excess relative risk (ERR) 

Probability of Causation (PC) 59.98 80.23 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 467 1068Original ERR/Sv 19.4432 52.5682 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.8537 0.9041 w/ latency adjustment 

 Random errors in dosesb 0.0629 0.0480 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0686 1.1888 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0323 1.0882 adjusted for population transfer  Systematic errors in RBE neutron dosesb 1.0260 0.9595 multiplicative risk model  Model Mixture factor for transfer to US pop 0.6565 0.2599 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.0122 0.9642 Smoking history 1 1 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 3.757 9.376 Excess relative risk (ERR) 

Probability of Causation (PC) 78.98 90.36 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1478 1307Original ERR/Sv 22.5457 64.6187 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.9991 0.9991 w/ latency adjustment 

 Random errors in dosesb 0.0520 0.0582 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1780 1.2421 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0737 1.1551 adjusted for population transfer  Systematic errors in RBE neutron dosesb 0.9905 0.9937 multiplicative risk model  Model Mixture factor for transfer to US pop 0.2407 0.1235 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9401 0.9536 Smoking history 1 1 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 4.334 11.033 Excess relative risk (ERR) 

Probability of Causation (PC) 81.25 91.69 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 835 257Original ERR/Sv 12.7894 23.9340 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0759 0.0752 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1948 1.0813 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0708 1.0673 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0510 0.9347 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1494 0.0878 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9172 0.8171 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 2.283 4.771 Excess relative risk (ERR) 

Probability of Causation (PC) 69.54 82.67 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1466 257Original ERR/Sv 7.1284 11.2723 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0485 0.0752 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1621 1.0813 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2190 1.0673 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0016 0.9347 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4194 0.0878 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9103 0.8171 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.198 2.247 Excess relative risk (ERR) 

Probability of Causation (PC) 54.51 69.20 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1455 1228Original ERR/Sv 19.6164 51.7196 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.3138 0.3534 w/ latency adjustment 

 Random errors in dosesb 0.0548 0.0566 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0563 1.0414 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1513 1.2215 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9968 1.0197 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0537 1.0358 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7024 0.6195 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.306 3.622 Excess relative risk (ERR) 

Probability of Causation (PC) 56.64 78.36 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 676 1174Original ERR/Sv 24.6924 57.0444 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.8351 0.8291 w/ latency adjustment 

 Random errors in dosesb 0.0419 0.0494 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1937 1.1336 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0738 1.0334 adjusted for population transfer  Systematic errors in RBE neutron dosesb 1.0744 1.0245 multiplicative risk model  Model Mixture factor for transfer to US pop 0.5558 0.5960 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.7013 0.6435 Smoking history 1 1 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 3.246 8.496 Excess relative risk (ERR) 

Probability of Causation (PC) 76.45 89.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 497 696Original ERR/Sv 27.8680 48.9323 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.9991 0.9988 w/ latency adjustment 

 Random errors in dosesb 0.0704 0.0654 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3507 1.0995 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0348 1.0579 adjusted for population transfer  Systematic errors in RBE neutron dosesb 0.9409 0.9022 multiplicative risk model  Model Mixture factor for transfer to US pop 0.0657 0.3303 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.6702 0.7432 Smoking history 1 1 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 3.763 9.861 Excess relative risk (ERR) 

Probability of Causation (PC) 79.01 90.79 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1316 355Original ERR/Sv 11.7623 22.3211 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0666 0.0641 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0552 1.2293 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0719 1.0671 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0674 1.0085 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4810 1.0301 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.6011 0.5584 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.978 4.366 Excess relative risk (ERR) 

Probability of Causation (PC) 66.42 81.36 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_leu_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1497 355Original ERR/Sv 4.8961 10.6383 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0516 0.0641 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0658 1.2293 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1082 1.0671 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0072 1.0085 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0008 1.0301 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.5869 0.5584 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.039 2.081 Excess relative risk (ERR) 

Probability of Causation (PC) 50.96 67.54 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 960 615Original ERR/Sv 0.4732 3.5684 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.0534 0.1331 w/ latency adjustment 

 Random errors in dosesb 0.1023 0.0771 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1296 1.3284 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1135 1.1353 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0736 1.0160 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7093 0.4805 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0998 0.8829 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.005 0.095 Excess relative risk (ERR) 

Probability of Causation (PC) 0.50 8.67 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 33 177Original ERR/Sv 1.2389 17.5745 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.1158 0.1132 w/ latency adjustment 

 Random errors in dosesb 0.0711 0.0862 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1007 1.1073 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0791 1.0935 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0171 0.9887 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6482 0.5877 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9051 0.7928 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.029 0.398 Excess relative risk (ERR) 

Probability of Causation (PC) 2.79 28.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 501 110Original ERR/Sv 1.6360 13.1733 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.7816 0.7333 w/ latency adjustment 

 Random errors in dosesb 0.1249 0.0725 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1130 1.2467 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1438 1.1138 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0497 0.9199 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8638 1.0601 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9507 1.0616 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.256 1.932 Excess relative risk (ERR) 

Probability of Causation (PC) 20.37 65.89 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.9999 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC) 26.50 71.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC) 26.50 71.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 960 615Original ERR/Sv 0.4732 3.5684 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.0534 0.1331 w/ latency adjustment 

 Random errors in dosesb 0.1023 0.0771 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1296 1.3284 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1135 1.1353 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0736 1.0160 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7093 0.4805 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0998 0.8829 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.005 0.095 Excess relative risk (ERR) 

Probability of Causation (PC) 0.50 8.67 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 33 177Original ERR/Sv 1.2389 17.5745 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.1158 0.1132 w/ latency adjustment 

 Random errors in dosesb 0.0711 0.0862 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1007 1.1073 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0791 1.0935 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0171 0.9887 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6482 0.5877 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9051 0.7928 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.029 0.398 Excess relative risk (ERR) 

Probability of Causation (PC) 2.79 28.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 501 110Original ERR/Sv 1.6360 13.1733 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.7816 0.7333 w/ latency adjustment 

 Random errors in dosesb 0.1249 0.0725 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1130 1.2467 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1438 1.1138 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0497 0.9199 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8638 1.0601 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.1264 1.1110 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.256 1.932 Excess relative risk (ERR) 

Probability of Causation (PC) 20.37 65.89 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 0.9999 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.1314 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC) 26.50 71.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_thy_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.1314 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.361 2.487 Excess relative risk (ERR) 

Probability of Causation (PC) 26.50 71.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1792 1305Original ERR/Sv 1.0605 0.9368 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 5.9686 7.6236 w/ age adjustment 

 Minimum latency for cancer induction 0.0004 0.0090 w/ latency adjustment 

 Random errors in dosesb 0.0951 0.0791 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2682 1.1818 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1225 1.0316 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9776 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9782 0.7841 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1513 1.1033 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.012 Excess relative risk (ERR) 

Probability of Causation (PC) 0.04 1.20 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 188 1923Original ERR/Sv 0.6274 0.5908 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 8.4962 35.2508 w/ age adjustment 

 Minimum latency for cancer induction 0.0016 0.0104 w/ latency adjustment 

 Random errors in dosesb 0.0772 0.0613 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3327 1.0740 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0737 1.1482 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0262 0.9735 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9788 0.5712 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0889 1.1418 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.001 0.040 Excess relative risk (ERR) 

Probability of Causation (PC) 0.13 3.89 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 449 389Original ERR/Sv 0.5450 1.2675 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.9627 4.7570 w/ age adjustment 

 Minimum latency for cancer induction 0.0364 0.2948 w/ latency adjustment 

 Random errors in dosesb 0.0608 0.1133 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1937 1.0389 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0650 1.0720 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9391 1.0083 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3303 0.8781 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1618 1.0707 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.015 0.355 Excess relative risk (ERR) 

Probability of Causation (PC) 1.53 26.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 100 679Original ERR/Sv 0.5280 1.3131 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.4389 5.5058 w/ age adjustment 

 Minimum latency for cancer induction 0.9807 0.9936 w/ latency adjustment 

 Random errors in dosesb 0.1172 0.0806 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0752 1.1779 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0854 1.2094 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0828 1.0298 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4937 0.3402 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1011 1.1122 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.331 1.137 Excess relative risk (ERR) 

Probability of Causation (PC) 24.87 53.20 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 8 863

Original ERR/Sv 0.7674 1.2030 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.9150 3.6410 w/ age adjustment 

 Minimum latency for cancer induction 0.9994 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1118 0.0980 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1480 1.1717 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1154 1.0944 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9422 0.9488 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5063 0.1230 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0805 1.0680 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.281 0.838 Excess relative risk (ERR) 

Probability of Causation (PC) 21.96 45.58 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1922 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1486 285Original ERR/Sv 0.9995 0.6834 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 6.4592 19.0859 w/ age adjustment 

 Minimum latency for cancer induction 0.0004 0.0060 w/ latency adjustment 

 Random errors in dosesb 0.0850 0.0804 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3053 1.2404 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1119 1.0918 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9955 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3897 0.8759 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8809 0.8251 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.013 Excess relative risk (ERR) 

Probability of Causation (PC) 0.04 1.26 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1923 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 65 1923

Original ERR/Sv 0.4099 0.6986 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 10.4110 35.2508 w/ age adjustment 

 Minimum latency for cancer induction 0.0015 0.0104 w/ latency adjustment 

 Random errors in dosesb 0.0763 0.0613 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0138 1.0740 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0806 1.1482 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9483 0.9735 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9749 0.5712 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8199 0.8180 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.001 0.042 Excess relative risk (ERR) 

Probability of Causation (PC) 0.14 3.99 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1925 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 936 1923Original ERR/Sv 1.0225 0.6986 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 5.0850 25.0307 w/ age adjustment 

 Minimum latency for cancer induction 0.0205 0.1309 w/ latency adjustment 

 Random errors in dosesb 0.1372 0.0613 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1892 1.0740 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0776 1.1482 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9998 0.9735 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0867 0.5712 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8526 0.8180 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.016 0.373 Excess relative risk (ERR) 

Probability of Causation (PC) 1.61 27.18 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1930 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 877 1048Original ERR/Sv 1.0566 0.7934 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5890 8.3950 w/ age adjustment 

 Minimum latency for cancer induction 0.9933 0.9602 w/ latency adjustment 

 Random errors in dosesb 0.0871 0.1301 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3478 1.1156 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1307 1.0635 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9983 0.9614 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2225 0.4904 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8480 0.7949 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.343 1.135 Excess relative risk (ERR) 

Probability of Causation (PC) 25.51 53.16 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier latency_col_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1935 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1068 264Original ERR/Sv 0.7971 1.2210 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2995 4.9568 w/ age adjustment 

 Minimum latency for cancer induction 0.9994 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0947 0.0843 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0315 1.1285 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1507 1.1858 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0170 1.0553 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1444 -0.0481 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8598 0.8858 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.292 0.818 Excess relative risk (ERR) 

Probability of Causation (PC) 22.63 45.00 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix D 

Verification of the Implementation of the Radiation Effectiveness Factors (REF) for 

Exposure to Alpha Radiation, Neutrons, and Low Energy Photons and Beta Particles 

The calculations documented in this appendix were performed to verify that the 

algorithms describing the radiation effectiveness factor (REF) have been implemented 

correctly. A total of 44 calculations was performed for this specific verification task. 

The equations related to REF do not depend on gender or on the value of the dose; 

therefore, all calculations were performed for males with an organ equivalent dose of 

20 cSv. The age at time of exposure (AAE) was kept constant at 20 years of age, and the 

age at diagnosis or attained age (ATA) was kept constant at 40 years of age. 

Further details about this verification task can be found in Section 5.3 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

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Verification Run Identifier REF_e1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 737 1719Original ERR/Sv 3.3313 3.9564 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0509 0.0420 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2158 1.2031 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0891 1.0979 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0236 1.0288 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8490 0.9898 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9251 0.8702 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.45392 5.78338 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.868 7.558 Excess relative risk (ERR) 

Probability of Causation (PC) 65.14 88.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 122 463Original ERR/Sv 4.0647 4.0786 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0515 0.0501 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2085 1.1953 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1858 1.1792 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9589 0.9679 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4469 0.2236 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9424 0.9426 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.11051 6.22876 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.271 3.737 Excess relative risk (ERR) 

Probability of Causation (PC) 55.97 78.89 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 648 742Original ERR/Sv 0.5517 1.5568 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.1502 3.0225 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0778 0.0793 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2410 1.1807 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1699 1.0411 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0205 0.9463 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0768 0.5217 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1072 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.88282 2.41056 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.547 2.210 Excess relative risk (ERR) 

Probability of Causation (PC) 35.35 68.84 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 573 803Original ERR/Sv 0.2982 0.6278 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.7782 2.2604 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1031 0.0861 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1026 1.1119 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0388 1.2424 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9684 0.9452 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9513 0.5630 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1277 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.97823 5.06335 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.328 1.816 Excess relative risk (ERR) 

Probability of Causation (PC) 24.70 64.49 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1077 1978Original ERR/Sv 3.3058 5.0967 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0709 0.0352 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1105 1.0251 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1839 1.0784 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9956 0.9682 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2170 0.8836 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9630 0.8981 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.630 1.169 Excess relative risk (ERR) 

Probability of Causation (PC) 38.66 53.90 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 409 1978Original ERR/Sv 3.3387 5.0967 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0371 0.0352 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1373 1.0251 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0313 1.0784 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0864 0.9682 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4211 0.8836 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9421 0.8981 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.525 0.974 Excess relative risk (ERR) 

Probability of Causation (PC) 34.44 49.35 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 696

Original ERR/Sv 0.3770 1.0795 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.1638 3.0345 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0940 0.1031 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0880 1.1456 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1132 1.0861 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0640 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9232 -0.0929 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1143 1.1538 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.229 0.638 Excess relative risk (ERR) 

Probability of Causation (PC) 18.61 38.93 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_e2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.138 0.623 Excess relative risk (ERR) 

Probability of Causation (PC) 12.11 38.37 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1169 1938Original ERR/Sv 2.9781 3.6460 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0476 0.0596 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0453 1.0848 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0910 1.0775 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9730 0.9269 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2979 0.1708 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9277 0.9357 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.31869 6.56067 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.812 10.242 Excess relative risk (ERR) 

Probability of Causation (PC) 64.43 91.10 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 194 1351Original ERR/Sv 4.0856 3.5182 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0637 0.0469 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0418 1.1737 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2238 1.2482 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9571 1.0363 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5839 0.3287 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9174 1.0169 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.76404 8.98501 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.213 4.409 Excess relative risk (ERR) 

Probability of Causation (PC) 54.82 81.51 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 819 11Original ERR/Sv 0.3887 1.3219 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.4669 2.6641 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0781 0.0767 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1033 1.2804 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1649 1.0432 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0168 0.9935 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3765 0.0553 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1739 1.0601 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.01924 4.27865 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.529 2.584 Excess relative risk (ERR) 

Probability of Causation (PC) 34.62 72.10 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 652 1377Original ERR/Sv 0.8167 0.8327 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0983 2.8883 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0722 0.0703 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1633 1.0857 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1408 1.2234 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0234 1.0486 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2000 0.2792 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0550 1.1675 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.32002 3.77768 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.313 2.236 Excess relative risk (ERR) 

Probability of Causation (PC) 23.82 69.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1044 1611Original ERR/Sv 4.5775 2.9268 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0695 0.0815 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3013 1.0567 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1558 1.1848 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9824 0.9876 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1813 0.8616 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8135 0.8954 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.72976 6.01692 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.307 6.691 Excess relative risk (ERR) 

Probability of Causation (PC) 56.66 87.00 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 237 260Original ERR/Sv 2.8315 4.2577 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0643 0.0636 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2214 1.0534 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0413 1.1018 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9613 0.9425 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4200 0.2803 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8450 0.9478 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.10433 4.20469 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.944 3.350 Excess relative risk (ERR) 

Probability of Causation (PC) 48.56 77.01 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1156 798Original ERR/Sv 0.8940 0.6767 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.7928 3.0582 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1013 0.0956 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2140 1.1105 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1691 1.1341 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0110 0.9501 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4678 0.5927 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1351 1.1392 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 4.78512 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.411 1.916 Excess relative risk (ERR) 

Probability of Causation (PC) 29.12 65.71 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 732 125Original ERR/Sv 0.4447 1.0690 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3892 3.1212 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0754 0.0787 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0596 1.2258 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2799 1.1103 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0272 0.9891 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1884 1.0301 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1271 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.64536 3.17219 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.239 1.691 Excess relative risk (ERR) 

Probability of Causation (PC) 19.31 62.84 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p3_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1077 1978Original ERR/Sv 3.3058 5.0967 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0709 0.0352 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1105 1.0251 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1839 1.0784 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9956 0.9682 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2170 0.8836 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9630 0.8981 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.630 1.169 Excess relative risk (ERR) 

Probability of Causation (PC) 38.66 53.90 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p3_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 409 1978Original ERR/Sv 3.3387 5.0967 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0371 0.0352 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1373 1.0251 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0313 1.0784 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0864 0.9682 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4211 0.8836 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9421 0.8981 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.525 0.974 Excess relative risk (ERR) 

Probability of Causation (PC) 34.44 49.35 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p3_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 696

Original ERR/Sv 0.3770 1.0795 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.1638 3.0345 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0940 0.1031 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0880 1.1456 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1132 1.0861 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0640 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9232 -0.0929 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1143 1.1538 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.229 0.638 Excess relative risk (ERR) 

Probability of Causation (PC) 18.61 38.93 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_p3_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.138 0.623 Excess relative risk (ERR) 

Probability of Causation (PC) 12.11 38.37 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1168 1863Original ERR/Sv 2.9794 4.6321 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0492 0.0768 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0505 1.3579 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1730 1.0876 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9428 0.9552 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8297 0.7434 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9281 1.0099 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.6639 22.6404 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.283 3.210 Excess relative risk (ERR) 

Probability of Causation (PC) 22.07 76.25 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 893 1304Original ERR/Sv 3.1962 4.2474 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0443 0.0535 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1447 1.1349 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1528 1.0862 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9818 1.0232 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0031 0.8253 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9136 0.8827 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.01062 37.3473 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.378 5.191 Excess relative risk (ERR) 

Probability of Causation (PC) 27.41 83.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 598 1860Original ERR/Sv 0.5684 0.9772 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8842 2.8812 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0609 0.0708 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0084 1.1318 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2024 1.1584 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0384 1.0082 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9023 0.1087 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0547 1.1275 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.57945 7.5624 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.088 0.768 Excess relative risk (ERR) 

Probability of Causation (PC) 8.07 43.45 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1841 695Original ERR/Sv 1.0539 1.4381 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5868 2.4267 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1036 0.0711 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1265 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1562 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9531 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7082 0.4442 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1403 1.1330 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.17055 10.5672 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.118 1.290 Excess relative risk (ERR) 

Probability of Causation (PC) 10.56 56.33 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 622 593Original ERR/Sv 2.6089 5.1231 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0398 0.0597 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2127 1.1261 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2244 1.0806 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9883 1.0099 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8413 0.6944 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8503 0.9341 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.833 26.344 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.283 2.281 Excess relative risk (ERR) 

Probability of Causation (PC) 22.04 69.52 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 360 1240Original ERR/Sv 4.2680 3.6240 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0551 0.0516 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2367 1.0589 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0740 1.0536 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0052 0.9136 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4348 0.6218 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8916 0.8410 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 5.849 54.564 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.370 3.835 Excess relative risk (ERR) 

Probability of Causation (PC) 27.03 79.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1544 1522Original ERR/Sv 0.4755 0.9747 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2541 3.0469 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1047 0.0859 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1994 1.0911 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0822 1.0725 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0532 0.9942 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4497 0.2467 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1004 1.0967 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.6205 12.6988 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.084 0.755 Excess relative risk (ERR) 

Probability of Causation (PC) 7.79 43.03 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 836 1983Original ERR/Sv 0.6472 0.6421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3423 2.2287 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1045 0.0785 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0813 1.1324 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0119 1.0973 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0015 1.0345 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0482 0.8187 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0916 1.1006 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.3185 45.2512 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.110 1.107 Excess relative risk (ERR) 

Probability of Causation (PC) 9.93 52.53 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n3_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 544 338Original ERR/Sv 3.7446 4.7970 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0587 0.0495 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1399 1.2731 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1989 1.0970 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0023 0.9664 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8792 0.5602 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8427 0.9557 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 9.73919 64.6956 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.277 2.366 Excess relative risk (ERR) 

Probability of Causation (PC) 21.66 70.29 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n3_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1415 777Original ERR/Sv 5.0816 3.6332 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0562 0.0554 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0425 1.0906 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1652 1.1231 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9861 0.9829 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6224 0.6092 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9760 0.9136 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 8.48347 116.022 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.377 3.571 Excess relative risk (ERR) 

Probability of Causation (PC) 27.36 78.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n3_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 84 1942

Original ERR/Sv 0.3028 0.7333 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2976 3.4879 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0788 0.0840 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1116 1.2736 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1072 1.2174 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9297 1.0778 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0591 -0.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1250 1.0689 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 11.5544 31.4083 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.085 0.558 Excess relative risk (ERR) 

Probability of Causation (PC) 7.81 35.80 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n3_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 1677Original ERR/Sv 0.5755 0.5693 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8218 2.5114 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0822 0.0640 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.3633 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1657 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 0.9583 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.6983 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0458 1.1528 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.20048 84.3799 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.112 0.882 Excess relative risk (ERR) 

Probability of Causation (PC) 10.06 46.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n4_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1330 848Original ERR/Sv 3.9286 3.7270 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0607 0.0814 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0105 1.0466 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1462 1.1090 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0447 1.0196 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9997 0.6125 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8063 0.9474 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.117 39.672 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.284 2.647 Excess relative risk (ERR) 

Probability of Causation (PC) 22.09 72.58 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n4_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1352 212Original ERR/Sv 4.1628 2.4097 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0520 0.0519 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3059 1.0644 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2961 1.0915 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9392 1.0587 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3534 0.5250 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9087 0.8805 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.1775 105 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.372 4.082 Excess relative risk (ERR) 

Probability of Causation (PC) 27.12 80.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n4_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1393 1859Original ERR/Sv 1.3824 0.6075 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.0109 3.3570 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0782 0.0662 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2436 1.0871 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2485 1.2190 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9614 0.9553 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5701 0.2671 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1490 1.0708 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.3075 19.3287 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.084 0.698 Excess relative risk (ERR) 

Probability of Causation (PC) 7.72 41.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n4_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 499 1616Original ERR/Sv 1.0031 0.5636 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0506 2.1769 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0876 0.0979 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2327 1.1245 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0945 1.1433 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0042 1.0494 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5091 0.0993 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1264 1.1090 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.0885 48.6938 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.108 1.068 Excess relative risk (ERR) 

Probability of Causation (PC) 9.77 51.64 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n5_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 370 856Original ERR/Sv 2.8287 3.9754 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0543 0.0410 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1338 1.1938 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0611 1.1015 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9953 0.9459 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0089 0.4552 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9016 1.0162 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.9003 21.8771 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.289 2.937 Excess relative risk (ERR) 

Probability of Causation (PC) 22.43 74.60 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n5_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1009 579Original ERR/Sv 4.8044 2.8521 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0584 0.0438 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1298 1.0203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2266 1.1806 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9622 0.9353 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5927 0.2264 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9283 0.8916 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.5301 49.4733 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.375 4.792 Excess relative risk (ERR) 

Probability of Causation (PC) 27.26 82.73 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n5_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 351 724Original ERR/Sv 0.5076 0.6082 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2086 3.2598 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0830 0.1079 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1474 1.2603 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0988 1.1178 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9136 0.9834 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3820 0.1950 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1041 1.0805 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.0186 11.676 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.091 0.788 Excess relative risk (ERR) 

Probability of Causation (PC) 8.31 44.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n5_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 432 1507Original ERR/Sv 0.4875 0.5911 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2446 2.3776 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0942 0.0824 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0921 1.0788 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1829 1.1847 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9534 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7527 0.8814 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1555 1.1216 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.9871 23.148 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.121 1.140 Excess relative risk (ERR) 

Probability of Causation (PC) 10.76 53.26 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n6_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1962 392Original ERR/Sv 3.7716 3.7433 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0475 0.0399 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1686 1.0834 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1274 1.0940 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9343 0.9412 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0729 0.6906 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9703 0.8852 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 9.0345 66.4965 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.282 2.238 Excess relative risk (ERR) 

Probability of Causation (PC) 22.00 69.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n6_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 397 1634Original ERR/Sv 3.0166 3.4252 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0601 0.0904 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0692 1.2198 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1698 1.2133 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9271 0.9175 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0383 0.3798 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8795 0.9022 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 15.4292 137.73 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.376 3.559 Excess relative risk (ERR) 

Probability of Causation (PC) 27.34 78.06 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n6_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 489 373Original ERR/Sv 0.5552 0.6401 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7826 3.4286 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0622 0.1128 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1836 1.1025 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2389 1.1238 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0387 0.9770 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0361 0.5190 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1376 1.1051 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.5991 27.15 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.083 0.575 Excess relative risk (ERR) 

Probability of Causation (PC) 7.65 36.53 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_n6_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 350 1056Original ERR/Sv 0.4610 1.2579 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8914 1.9648 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0721 0.1035 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0859 1.0797 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2557 1.0394 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9551 1.0406 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5228 0.8622 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0910 1.0618 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 9.49538 36.6631 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.109 0.864 Excess relative risk (ERR) 

Probability of Causation (PC) 9.81 46.34 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_a_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 436 1016Original ERR/Sv 3.0031 4.6532 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0685 0.0664 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2503 1.3301 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1177 1.1065 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0324 0.9486 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1153 0.6015 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7859 0.7885 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 5.86772 55.7569 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.106 1.815 Excess relative risk (ERR) 

Probability of Causation (PC) 9.57 64.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_a_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Leukemia Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 436 1016Original ERR/Sv 3.0031 4.6532 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0685 0.0664 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2503 1.3301 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1177 1.1065 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0324 0.9486 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1153 0.6015 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7859 0.7885 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 5.86772 55.7569 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.106 1.815 Excess relative risk (ERR) 

Probability of Causation (PC) 9.57 64.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_a_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.121 1.492 Excess relative risk (ERR) 

Probability of Causation (PC) 10.80 59.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier REF_a_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.121 1.492 Excess relative risk (ERR) 

Probability of Causation (PC) 10.80 59.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix E 

Verification of the Implementation of the DDREF for Low Dose and High Dose 

Acute and Chronic Exposures 

The calculations documented in this appendix were performed to verify that the 

dose and dose rate effectiveness factor (DDREF) has been implemented correctly. A 

total of 132 calculations was performed for this specific verification task. 

To test all possible applications of DDREF, a series of calculations has been 

performed for chronic and acute exposures to each radiation type, assuming doses of 5 

cSv and 30 cSv. Separate verification calculations were performed for thyroid cancer, 

breast cancer, and colon cancer (colon cancer was selected to represent solid tumors other 

than breast and thyroid), because DDREF is different for each of these cancer groupings. 

The age at exposure (AAE) was kept constant at 20 years of age, and the age at diagnosis 

(attained age, ATA) was kept constant at 40 years of age. Because the DDREF is 

independent of gender, males were used for thyroid and colon cancer calculations; 

however females were used for breast cancer calculations. 

Further details about this verification task can be found in Section 5.4 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

This page was intentionally left blank. 
Verification Run Identifier DDREF_e1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 129 1391Original ERR/Sv 2.3208 16.2426 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1220 0.1065 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1863 1.1565 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1265 1.0677 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9612 0.9794 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4876 0.0245 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.0796 0.8537 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.00377 1.00505 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.86856 2.28727 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.216 1.848 Excess relative risk (ERR) 

Probability of Causation (PC) 17.76 64.89 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 653 518Original ERR/Sv 1.4938 13.4257 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1201 0.0751 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1795 1.2005 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1274 1.1817 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0274 0.9702 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7764 0.0823 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9425 0.9138 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.91823 2.76582 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.308 11.140 Excess relative risk (ERR) 

Probability of Causation (PC) 56.67 91.76 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1531 1549Original ERR/Sv 3.2512 14.5269 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0879 0.0751 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1607 1.1460 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1767 1.0969 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0663 0.9483 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0126 0.0823 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9593 0.8413 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.82871 2.15662 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.149 1.566 Excess relative risk (ERR) 

Probability of Causation (PC) 12.94 61.04 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1531 1549Original ERR/Sv 3.2512 14.5269 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0879 0.0751 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1607 1.1460 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1767 1.0969 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0663 0.9483 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0126 0.0823 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.9593 0.8413 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.82871 2.15662 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.892 9.399 Excess relative risk (ERR) 

Probability of Causation (PC) 47.14 90.38 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 149 742Original ERR/Sv 0.5761 1.5568 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5804 3.0225 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0978 0.0793 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1692 1.1807 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1334 1.0411 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0507 0.9463 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9980 0.5217 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1122 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.30753 2.41056 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.135 0.552 Excess relative risk (ERR) 

Probability of Causation (PC) 11.92 35.58 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 648 742Original ERR/Sv 0.5517 1.5568 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.1502 3.0225 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0778 0.0793 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2410 1.1807 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1699 1.0411 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0205 0.9463 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0768 0.5217 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1072 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.88282 2.41056 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.820 3.314 Excess relative risk (ERR) 

Probability of Causation (PC) 45.06 76.82 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 573 803Original ERR/Sv 0.2982 0.6278 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.7782 2.2604 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1031 0.0861 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1026 1.1119 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0388 1.2424 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9684 0.9452 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9513 0.5630 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1277 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.97823 5.06335 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.082 0.454 Excess relative risk (ERR) 

Probability of Causation (PC) 7.58 31.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 573 803Original ERR/Sv 0.2982 0.6278 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.7782 2.2604 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1031 0.0861 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1026 1.1119 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0388 1.2424 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9684 0.9452 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9513 0.5630 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1277 1.1453 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.97823 5.06335 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.492 2.724 Excess relative risk (ERR) 

Probability of Causation (PC) 32.97 73.15 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 151 963Original ERR/Sv 2.6115 2.3979 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0642 0.0920 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2948 1.1052 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2574 1.0994 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9160 0.9081 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.7247 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3499 0.3395 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.14489 4.66376 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.103 0.453 Excess relative risk (ERR) 

Probability of Causation (PC) 9.30 31.17 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 863 963Original ERR/Sv 3.4742 2.3979 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1033 0.0920 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1717 1.1052 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0944 1.0994 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9488 0.9081 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.7247 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3399 0.3395 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.92951 4.66376 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.620 2.717 Excess relative risk (ERR) 

Probability of Causation (PC) 38.27 73.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 850 613Original ERR/Sv 2.5892 2.2594 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0980 0.0845 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0423 1.1004 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0753 1.1466 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9889 0.9671 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0164 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3294 0.3353 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.5 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.52453 5.74215 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.071 0.389 Excess relative risk (ERR) 

Probability of Causation (PC) 6.64 27.98 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e1_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E<15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 850 613Original ERR/Sv 2.5892 2.2594 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0980 0.0845 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0423 1.1004 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0753 1.1466 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9889 0.9671 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0164 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3294 0.3353 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.5 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.52453 5.74215 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.427 2.332 Excess relative risk (ERR) 

Probability of Causation (PC) 29.90 69.98 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 790 414Original ERR/Sv 1.6054 11.6797 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0674 0.0824 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0591 1.1505 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0960 1.1152 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0738 1.0054 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8314 0.2115 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8237 0.9015 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.080 0.584 Excess relative risk (ERR) 

Probability of Causation (PC) 7.43 36.87 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.541 3.730 Excess relative risk (ERR) 

Probability of Causation (PC) 35.11 78.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 548 605Original ERR/Sv 1.2206 10.6068 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0652 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0207 1.3331 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2289 1.2075 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0048 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8264 0.1246 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8425 0.9005 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.061 0.530 Excess relative risk (ERR) 

Probability of Causation (PC) 5.75 34.66 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 548 605Original ERR/Sv 1.2206 10.6068 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0652 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0207 1.3331 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2289 1.2075 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0048 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8264 0.1246 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8425 0.9005 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.366 3.183 Excess relative risk (ERR) 

Probability of Causation (PC) 26.80 76.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 59 884Original ERR/Sv 0.6618 0.7539 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8088 2.8682 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0988 0.0948 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1571 1.1472 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2106 1.0827 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0112 0.9222 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8495 0.2940 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0934 1.1242 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.45989 0.735022 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.050 0.153 Excess relative risk (ERR) 

Probability of Causation (PC) 4.77 13.26 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 696

Original ERR/Sv 0.3770 1.0795 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.1638 3.0345 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0940 0.1031 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0880 1.1456 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1132 1.0861 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0640 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9232 -0.0929 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1143 1.1538 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.343 0.956 Excess relative risk (ERR) 

Probability of Causation (PC) 25.54 48.88 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.034 0.156 Excess relative risk (ERR) 

Probability of Causation (PC) 3.33 13.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.207 0.934 Excess relative risk (ERR) 

Probability of Causation (PC) 17.13 48.29 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 788 231Original ERR/Sv 2.4376 3.1266 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0993 0.0898 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1376 1.3255 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0768 1.0747 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0039 0.9074 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9518 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3359 0.3294 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.037 0.128 Excess relative risk (ERR) 

Probability of Causation (PC) 3.53 11.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 558 6

Original ERR/Sv 2.7245 2.9301 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0966 0.1071 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2018 1.1609 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1199 1.0821 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9459 1.0038 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0587 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3413 0.3385 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.240 0.802 Excess relative risk (ERR) 

Probability of Causation (PC) 19.37 44.50 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 259 273Original ERR/Sv 1.7740 2.0978 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0806 0.0688 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0444 1.0758 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1114 1.1710 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9150 0.9779 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0205 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3266 0.3388 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.029 0.132 Excess relative risk (ERR) 

Probability of Causation (PC) 2.86 11.64 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_e2_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type electrons E>15keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 259 273Original ERR/Sv 1.7740 2.0978 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0806 0.0688 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0444 1.0758 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1114 1.1710 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9150 0.9779 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0205 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3266 0.3388 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.177 0.791 Excess relative risk (ERR) 

Probability of Causation (PC) 15.03 44.15 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 202 1290Original ERR/Sv 3.3262 7.1230 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0935 0.0776 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2772 1.2338 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1395 1.0999 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0023 0.9466 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2913 0.6636 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9479 1.0830 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.30038 5.36297 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.216 1.910 Excess relative risk (ERR) 

Probability of Causation (PC) 17.78 65.64 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 315 1290Original ERR/Sv 1.0408 7.1230 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0843 0.1406 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2633 1.2594 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1776 1.1597 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0326 1.0321 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6691 0.3160 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9039 0.9300 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.2401 5.36297 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.324 11.460 Excess relative risk (ERR) 

Probability of Causation (PC) 56.97 91.97 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 774 1207Original ERR/Sv 1.8317 4.0535 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0761 0.0798 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3088 1.1142 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0529 1.2417 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0063 1.0192 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0328 0.1835 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1069 0.9320 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.5 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.30175 5.8013 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.141 1.680 Excess relative risk (ERR) 

Probability of Causation (PC) 12.32 62.68 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 774 1207Original ERR/Sv 1.8317 4.0535 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0761 0.0798 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3088 1.1142 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0529 1.2417 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0063 1.0192 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0328 0.1835 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1069 0.9320 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.5 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.30175 5.8013 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.843 10.080 Excess relative risk (ERR) 

Probability of Causation (PC) 45.75 90.97 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1013 11

Original ERR/Sv 0.8745 1.3219 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.6726 2.6641 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1076 0.0767 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1924 1.2804 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0591 1.0432 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0008 0.9935 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8116 0.0553 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0985 1.0601 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.24381 4.27865 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.130 0.646 Excess relative risk (ERR) 

Probability of Causation (PC) 11.4851 39.25 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 819 11Original ERR/Sv 0.3887 1.3219 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.4669 2.6641 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0781 0.0767 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1033 1.2804 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1649 1.0432 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0168 0.9935 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3765 0.0553 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1739 1.0601 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.01924 4.27865 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.794 3.876 Excess relative risk (ERR) 

Probability of Causation (PC) 44.27 79.49 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 652 1377Original ERR/Sv 0.8167 0.8327 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0983 2.8883 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0722 0.0703 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1633 1.0857 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1408 1.2234 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0234 1.0486 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2000 0.2792 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0550 1.1675 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.32002 3.77768 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.078 0.559 Excess relative risk (ERR) 

Probability of Causation (PC) 7.25 35.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 652 1377Original ERR/Sv 0.8167 0.8327 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0983 2.8883 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0722 0.0703 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1633 1.0857 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1408 1.2234 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0234 1.0486 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2000 0.2792 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0550 1.1675 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.32002 3.77768 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.469 3.353 Excess relative risk (ERR) 

Probability of Causation (PC) 31.92 77.03 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 564 1908Original ERR/Sv 2.5345 2.6636 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0575 0.0989 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1241 1.1341 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1631 1.2213 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0455 0.9332 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.6900 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3300 0.3452 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.14463 5.75091 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.102 0.519 Excess relative risk (ERR) 

Probability of Causation (PC) 9.23 34.17 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 168 1908Original ERR/Sv 2.9698 2.6636 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1011 0.0989 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1307 1.1341 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0886 1.2213 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0185 0.9332 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4541 0.6900 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3420 0.3452 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.23821 5.75091 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.621 3.114 Excess relative risk (ERR) 

Probability of Causation (PC) 38.30 75.69 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 256 1995Original ERR/Sv 2.3043 2.3629 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0664 0.1033 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1478 1.3079 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1798 1.0255 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9291 1.0194 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.2830 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3369 0.3324 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.11591 9.71223 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.070 0.483 Excess relative risk (ERR) 

Probability of Causation (PC) 6.51 32.56 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p1_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E<30keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 256 1995Original ERR/Sv 2.3043 2.3629 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0664 0.1033 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1478 1.3079 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1798 1.0255 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9291 1.0194 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.2830 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3369 0.3324 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.11591 9.71223 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.418 2.896 Excess relative risk (ERR) 

Probability of Causation (PC) 29.46 74.33 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1763 1076Original ERR/Sv 1.7082 10.2832 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0912 0.0714 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1999 1.2052 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2055 1.0255 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9858 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9870 0.9458 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8279 0.7518 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.90845 2.85954 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.163 1.470 Excess relative risk (ERR) 

Probability of Causation (PC) 14.02 59.52 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 670 1076Original ERR/Sv 1.4246 10.2832 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1013 0.0797 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2272 1.2901 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0988 1.1920 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0591 1.0205 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8341 -0.0308 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0842 0.9452 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.35844 2.85954 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.008 8.826 Excess relative risk (ERR) 

Probability of Causation (PC) 50.20 89.82 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 30 805Original ERR/Sv 0.9762 10.0752 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0896 0.0785 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1524 1.1510 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1364 1.2396 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9169 1.0611 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7780 0.8946 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8579 0.7953 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.26151 2.53024 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.110 1.275 Excess relative risk (ERR) 

Probability of Causation (PC) 9.94 56.04 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 30 805Original ERR/Sv 0.9762 10.0752 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0896 0.0785 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1524 1.1510 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1364 1.2396 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9169 1.0611 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7780 0.8946 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8579 0.7953 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.26151 2.53024 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.662 7.648 Excess relative risk (ERR) 

Probability of Causation (PC) 39.84 88.44 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 121 798Original ERR/Sv 0.4529 0.6767 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3362 3.0582 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0922 0.0956 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3565 1.1105 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0142 1.1341 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0100 0.9501 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0668 0.5927 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0897 1.1392 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.1386 4.78512 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.096 0.479 Excess relative risk (ERR) 

Probability of Causation (PC) 8.79 32.39 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1156 798Original ERR/Sv 0.8940 0.6767 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.7928 3.0582 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1013 0.0956 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2140 1.1105 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1691 1.1341 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0110 0.9501 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4678 0.5927 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1351 1.1392 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 4.78512 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.616 2.875 Excess relative risk (ERR) 

Probability of Causation (PC) 38.13 74.19 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 732 125Original ERR/Sv 0.4447 1.0690 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3892 3.1212 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0754 0.0787 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0596 1.2258 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2799 1.1103 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0272 0.9891 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1884 1.0301 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1271 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.64536 3.17219 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.060 0.423 Excess relative risk (ERR) 

Probability of Causation (PC) 5.65 29.71 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 732 125Original ERR/Sv 0.4447 1.0690 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3892 3.1212 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0754 0.0787 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0596 1.2258 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2799 1.1103 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0272 0.9891 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1884 1.0301 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1271 1.1039 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.64536 3.17219 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.359 2.536 Excess relative risk (ERR) 

Probability of Causation (PC) 26.42 71.72 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 592 329Original ERR/Sv 2.1697 4.3793 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0876 0.1061 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1699 1.1850 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1080 1.1734 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0159 0.9848 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2165 0.3925 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3320 0.3266 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.83187 3.94574 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.078 0.412 Excess relative risk (ERR) 

Probability of Causation (PC) 7.25 29.20 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 7 329

Original ERR/Sv 2.4729 4.3793 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0797 0.1061 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1677 1.1850 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0203 1.1734 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9851 0.9848 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0745 0.3925 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3459 0.3266 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.79983 3.94574 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.485 2.474 Excess relative risk (ERR) 

Probability of Causation (PC) 32.65 71.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 227 157Original ERR/Sv 1.6410 2.2400 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0756 0.0869 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3685 1.1435 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0853 1.1834 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0566 0.9721 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2451 0.8715 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3296 0.3449 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.85604 3.22499 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.054 0.390 Excess relative risk (ERR) 

Probability of Causation (PC) 5.08 28.08 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p2_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E=30-250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 227 157Original ERR/Sv 1.6410 2.2400 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0756 0.0869 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3685 1.1435 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0853 1.1834 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0566 0.9721 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2451 0.8715 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3296 0.3449 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.85604 3.22499 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.321 2.344 Excess relative risk (ERR) 

Probability of Causation (PC) 24.32 70.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 790 414Original ERR/Sv 1.6054 11.6797 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0674 0.0824 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0591 1.1505 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0960 1.1152 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0738 1.0054 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8314 0.2115 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8237 0.9015 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.080 0.584 Excess relative risk (ERR) 

Probability of Causation (PC) 7.43 36.87 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 679Original ERR/Sv 1.8032 12.4338 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1219 0.1094 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2233 1.2719 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1344 1.1032 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9443 0.9593 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3182 0.9210 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8074 0.8568 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.541 3.730 Excess relative risk (ERR) 

Probability of Causation (PC) 35.11 78.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 548 605Original ERR/Sv 1.2206 10.6068 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0652 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0207 1.3331 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2289 1.2075 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0048 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8264 0.1246 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8425 0.9005 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.061 0.530 Excess relative risk (ERR) 

Probability of Causation (PC) 5.75 34.66 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 548 605Original ERR/Sv 1.2206 10.6068 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0652 0.1271 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0207 1.3331 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2289 1.2075 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0048 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8264 0.1246 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8425 0.9005 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.366 3.183 Excess relative risk (ERR) 

Probability of Causation (PC) 26.80 76.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 59 884Original ERR/Sv 0.6618 0.7539 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8088 2.8682 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0988 0.0948 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1571 1.1472 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2106 1.0827 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0112 0.9222 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8495 0.2940 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0934 1.1242 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1.45989 0.735022 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.050 0.153 Excess relative risk (ERR) 

Probability of Causation (PC) 4.77 13.26 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 696

Original ERR/Sv 0.3770 1.0795 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.1638 3.0345 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0940 0.1031 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0880 1.1456 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1132 1.0861 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9508 1.0640 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9232 -0.0929 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1143 1.1538 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.343 0.956 Excess relative risk (ERR) 

Probability of Causation (PC) 25.54 48.88 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.034 0.156 Excess relative risk (ERR) 

Probability of Causation (PC) 3.33 13.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 965 170Original ERR/Sv 0.5957 0.7732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5536 2.4700 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0882 0.0738 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0737 1.2620 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0794 1.1310 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0961 0.9808 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6108 0.4277 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1488 1.1088 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 0.5 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.207 0.934 Excess relative risk (ERR) 

Probability of Causation (PC) 17.13 48.29 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 788 231Original ERR/Sv 2.4376 3.1266 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0993 0.0898 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1376 1.3255 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0768 1.0747 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0039 0.9074 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9518 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3359 0.3294 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.037 0.128 Excess relative risk (ERR) 

Probability of Causation (PC) 3.53 11.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 558 6

Original ERR/Sv 2.7245 2.9301 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0966 0.1071 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2018 1.1609 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1199 1.0821 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9459 1.0038 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0587 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3413 0.3385 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.240 0.802 Excess relative risk (ERR) 

Probability of Causation (PC) 19.37 44.50 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 259 273Original ERR/Sv 1.7740 2.0978 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0806 0.0688 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0444 1.0758 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1114 1.1710 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9150 0.9779 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0205 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3266 0.3388 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.029 0.132 Excess relative risk (ERR) 

Probability of Causation (PC) 2.86 11.64 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_p3_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 259 273Original ERR/Sv 1.7740 2.0978 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0806 0.0688 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0444 1.0758 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1114 1.1710 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9150 0.9779 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0205 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3266 0.3388 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.177 0.791 Excess relative risk (ERR) 

Probability of Causation (PC) 15.03 44.15 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 394 958Original ERR/Sv 1.8801 5.3485 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0741 0.1021 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1734 1.1686 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1538 1.1533 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0592 1.0643 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0564 0.2346 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8768 0.8952 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.9914 9.7896 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.037 0.524 Excess relative risk (ERR) 

Probability of Causation (PC) 3.61 34.37 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 394 958Original ERR/Sv 1.8801 5.3485 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0741 0.1021 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1734 1.1686 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1538 1.1533 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0592 1.0643 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0564 0.2346 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8768 0.8952 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.9914 9.7896 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.225 3.142 Excess relative risk (ERR) 

Probability of Causation (PC) 18.34 75.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 508 1010Original ERR/Sv 2.7489 16.8661 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0859 0.1109 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1741 1.2603 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1024 1.1297 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0473 1.0579 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4007 0.7406 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8833 0.8759 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.85573 5.2008 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.051 0.877 Excess relative risk (ERR) 

Probability of Causation (PC) 4.85 46.73 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 508 1010Original ERR/Sv 2.7489 16.8661 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0859 0.1109 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1741 1.2603 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1024 1.1297 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0473 1.0579 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4007 0.7406 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8833 0.8759 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.85573 5.2008 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.306 5.263 Excess relative risk (ERR) 

Probability of Causation (PC) 23.43 84.03 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 598 1860Original ERR/Sv 0.5684 0.9772 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8842 2.8812 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0609 0.0708 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0084 1.1318 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2024 1.1584 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0384 1.0082 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9023 0.1087 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0547 1.1275 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.57945 7.5624 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.022 0.192 Excess relative risk (ERR) 

Probability of Causation (PC) 2.15 16.11 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 598 1860Original ERR/Sv 0.5684 0.9772 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8842 2.8812 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0609 0.0708 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0084 1.1318 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2024 1.1584 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0384 1.0082 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9023 0.1087 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0547 1.1275 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.57945 7.5624 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.132 1.152 Excess relative risk (ERR) 

Probability of Causation (PC) 11.63 53.54 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1841 695Original ERR/Sv 1.0539 1.4381 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5868 2.4267 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1036 0.0711 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1265 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1562 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9531 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7082 0.4442 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1403 1.1330 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.17055 10.5672 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.030 0.322 Excess relative risk (ERR) 

Probability of Causation (PC) 2.87 24.38 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1841 695Original ERR/Sv 1.0539 1.4381 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.5868 2.4267 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1036 0.0711 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1265 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1562 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9531 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7082 0.4442 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1403 1.1330 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.17055 10.5672 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.177 1.935 Excess relative risk (ERR) 

Probability of Causation (PC) 15.05 65.93 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 989 734Original ERR/Sv 1.6517 1.7153 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1043 0.1057 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2034 1.0863 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1274 1.1530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0119 0.9371 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9216 1.0421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3362 0.3230 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.34695 9.8568 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.017 0.164 Excess relative risk (ERR) 

Probability of Causation (PC) 1.67 14.08 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1334 734Original ERR/Sv 2.8504 1.7153 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0699 0.1057 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1344 1.0863 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1378 1.1530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9920 0.9371 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3507 1.0421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3517 0.3230 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.22995 9.8568 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.102 0.983 Excess relative risk (ERR) 

Probability of Causation (PC) 9.24 49.57 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 739 1670Original ERR/Sv 2.7804 2.5360 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1015 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3019 1.1308 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1329 1.0792 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9948 1.0382 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.3276 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3357 0.3204 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.3429 21.1536 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.023 0.251 Excess relative risk (ERR) 

Probability of Causation (PC) 2.29 20.08 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n1_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E<10keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1677 1670Original ERR/Sv 2.3761 2.5360 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0671 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3633 1.1308 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1657 1.0792 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9583 1.0382 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.3276 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3421 0.3204 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.1124 21.1536 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.141 1.507 Excess relative risk (ERR) 

Probability of Causation (PC) 12.32 60.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1196 305Original ERR/Sv 1.6565 5.7326 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1043 0.0746 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1498 1.0803 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1741 1.1978 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0434 0.9420 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5465 0.3369 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0307 0.9900 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.2635 16.2687 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.035 0.466 Excess relative risk (ERR) 

Probability of Causation (PC) 3.41 31.80 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1196 305Original ERR/Sv 1.6565 5.7326 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1043 0.0746 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1498 1.0803 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1741 1.1978 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0434 0.9420 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5465 0.3369 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0307 0.9900 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.2635 16.2687 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.212 2.798 Excess relative risk (ERR) 

Probability of Causation (PC) 17.48 73.67 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1118 455Original ERR/Sv 4.4005 4.2668 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0836 0.0853 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1436 1.3378 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1787 1.0701 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9990 0.9984 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0002 0.7478 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8912 0.8499 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.067 33.4075 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.045 0.713 Excess relative risk (ERR) 

Probability of Causation (PC) 4.35 41.61 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1118 455Original ERR/Sv 4.4005 4.2668 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0836 0.0853 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1436 1.3378 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1787 1.0701 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9990 0.9984 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0002 0.7478 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8912 0.8499 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.067 33.4075 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.273 4.277 Excess relative risk (ERR) 

Probability of Causation (PC) 21.44 81.05 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1544 1522Original ERR/Sv 0.4755 0.9747 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2541 3.0469 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1047 0.0859 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1994 1.0911 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0822 1.0725 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0532 0.9942 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4497 0.2467 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1004 1.0967 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.6205 12.6988 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.189 Excess relative risk (ERR) 

Probability of Causation (PC) 2.07 15.88 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1544 1522Original ERR/Sv 0.4755 0.9747 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2541 3.0469 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1047 0.0859 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1994 1.0911 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0822 1.0725 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0532 0.9942 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4497 0.2467 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1004 1.0967 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.6205 12.6988 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.127 1.133 Excess relative risk (ERR) 

Probability of Causation (PC) 11.24 53.11 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 836 1983Original ERR/Sv 0.6472 0.6421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3423 2.2287 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1045 0.0785 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0813 1.1324 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0119 1.0973 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0015 1.0345 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0482 0.8187 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0916 1.1006 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.3185 45.2512 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.028 0.277 Excess relative risk (ERR) 

Probability of Causation (PC) 2.68 21.67 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 836 1983Original ERR/Sv 0.6472 0.6421 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.3423 2.2287 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1045 0.0785 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0813 1.1324 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0119 1.0973 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0015 1.0345 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0482 0.8187 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0916 1.1006 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.3185 45.2512 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.165 1.660 Excess relative risk (ERR) 

Probability of Causation (PC) 14.19 62.40 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 554 61Original ERR/Sv 2.1413 2.6722 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0922 0.1142 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0404 1.1304 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1168 1.1273 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9522 0.9921 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9815 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3440 0.3285 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.3355 13.2088 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.016 0.154 Excess relative risk (ERR) 

Probability of Causation (PC) 1.55 13.32 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 554 61Original ERR/Sv 2.1413 2.6722 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0922 0.1142 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0404 1.1304 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1168 1.1273 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9522 0.9921 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9815 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3440 0.3285 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.3355 13.2088 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.095 0.922 Excess relative risk (ERR) 

Probability of Causation (PC) 8.64 47.96 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 438 1175Original ERR/Sv 2.1238 2.1512 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0747 0.1042 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0549 1.1171 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2076 1.2374 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9823 1.0370 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0145 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3367 0.3245 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.99125 27.6788 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.232 Excess relative risk (ERR) 

Probability of Causation (PC) 2.10 18.80 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n2_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=10-100keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 438 1175Original ERR/Sv 2.1238 2.1512 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0747 0.1042 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0549 1.1171 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2076 1.2374 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9823 1.0370 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0145 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3367 0.3245 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.99125 27.6788 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.129 1.390 Excess relative risk (ERR) 

Probability of Causation (PC) 11.41 58.15 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1008 119Original ERR/Sv 1.2105 5.4016 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1147 0.0753 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1031 1.1543 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0937 1.0162 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9781 1.0738 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7753 0.7725 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0037 0.9566 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 11.6499 28.7627 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.035 0.388 Excess relative risk (ERR) 

Probability of Causation (PC) 3.41 27.98 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1008 119Original ERR/Sv 1.2105 5.4016 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1147 0.0753 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1031 1.1543 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0937 1.0162 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9781 1.0738 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7753 0.7725 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0037 0.9566 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 11.6499 28.7627 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.212 2.330 Excess relative risk (ERR) 

Probability of Causation (PC) 17.46 69.97 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 108 1815Original ERR/Sv 2.9132 10.4975 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1097 0.0844 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2021 1.1996 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0323 1.2298 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0042 1.0159 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0438 0.5267 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9577 0.7656 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.34842 23.801 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.046 0.625 Excess relative risk (ERR) 

Probability of Causation (PC) 4.42 38.45 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 108 1815Original ERR/Sv 2.9132 10.4975 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1097 0.0844 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2021 1.1996 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0323 1.2298 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0042 1.0159 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0438 0.5267 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9577 0.7656 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.34842 23.801 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.277 3.748 Excess relative risk (ERR) 

Probability of Causation (PC) 21.72 78.94 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 84 1942

Original ERR/Sv 0.3028 0.7333 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2976 3.4879 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0788 0.0840 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1116 1.2736 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1072 1.2174 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9297 1.0778 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0591 -0.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1250 1.0689 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 11.5544 31.4083 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.139 Excess relative risk (ERR) 

Probability of Causation (PC) 2.07 12.24 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 84 1942

Original ERR/Sv 0.3028 0.7333 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2976 3.4879 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0788 0.0840 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1116 1.2736 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1072 1.2174 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9297 1.0778 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0591 -0.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1250 1.0689 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 11.5544 31.4083 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.127 0.837 Excess relative risk (ERR) 

Probability of Causation (PC) 11.27 45.55 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 1677Original ERR/Sv 0.5755 0.5693 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8218 2.5114 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0822 0.0640 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.3633 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1657 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 0.9583 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.6983 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0458 1.1528 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.20048 84.3799 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.028 0.220 Excess relative risk (ERR) 

Probability of Causation (PC) 2.72 18.06 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 1677Original ERR/Sv 0.5755 0.5693 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8218 2.5114 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0822 0.0640 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.3633 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1657 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 0.9583 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.6983 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0458 1.1528 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.20048 84.3799 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.168 1.323 Excess relative risk (ERR) 

Probability of Causation (PC) 14.37 56.95 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 144 31Original ERR/Sv 2.2491 2.8302 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1001 0.1009 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1065 1.2501 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2635 1.2044 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9929 0.9850 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0267 0.9628 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3335 0.3463 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.9556 22.0455 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.017 0.113 Excess relative risk (ERR) 

Probability of Causation (PC) 1.69 10.15 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 144 31Original ERR/Sv 2.2491 2.8302 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1001 0.1009 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1065 1.2501 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2635 1.2044 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9929 0.9850 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0267 0.9628 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3335 0.3463 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.9556 22.0455 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.103 0.678 Excess relative risk (ERR) 

Probability of Causation (PC) 9.33 40.40 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 917 1490Original ERR/Sv 1.9716 2.5975 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1065 0.0707 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0972 1.2860 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1569 1.1519 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9861 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8380 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3412 0.3354 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 15.1504 43.5062 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.023 0.190 Excess relative risk (ERR) 

Probability of Causation (PC) 2.20 15.99 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n3_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=100keV-2MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 917 1490Original ERR/Sv 1.9716 2.5975 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1065 0.0707 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0972 1.2860 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1569 1.1519 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9861 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8380 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3412 0.3354 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 15.1504 43.5062 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.135 1.142 Excess relative risk (ERR) 

Probability of Causation (PC) 11.91 53.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1988 329Original ERR/Sv 4.2366 20.9632 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0589 0.1096 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0960 1.1227 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1571 1.1734 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0008 0.9897 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4101 0.6873 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.8280 0.7949 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.6335 4.6615 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.035 0.489 Excess relative risk (ERR) 

Probability of Causation (PC) 3.34 32.82 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1102 329Original ERR/Sv 1.8032 20.9632 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0773 0.1096 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0952 1.1227 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1750 1.1734 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0044 0.9897 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0580 0.6873 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.7727 0.7949 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.8375 4.6615 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.208 2.932 Excess relative risk (ERR) 

Probability of Causation (PC) 17.19 74.57 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 211 1108Original ERR/Sv 2.0690 8.9471 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1235 0.0771 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1421 1.2901 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0907 1.2104 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0225 1.0015 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0894 0.0515 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7332 1.0148 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.4185 15.2787 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.046 0.684 Excess relative risk (ERR) 

Probability of Causation (PC) 4.37 40.60 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 211 1108Original ERR/Sv 2.0690 8.9471 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1235 0.0771 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1421 1.2901 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0907 1.2104 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0225 1.0015 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0894 0.0515 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7332 1.0148 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 4.4185 15.2787 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.274 4.101 Excess relative risk (ERR) 

Probability of Causation (PC) 21.52 80.40 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1393 1859Original ERR/Sv 1.3824 0.6075 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.0109 3.3570 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0782 0.0662 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2436 1.0871 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2485 1.2190 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9614 0.9553 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5701 0.2671 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1490 1.0708 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.3075 19.3287 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.175 Excess relative risk (ERR) 

Probability of Causation (PC) 2.05 14.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1393 1859Original ERR/Sv 1.3824 0.6075 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.0109 3.3570 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0782 0.0662 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2436 1.0871 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2485 1.2190 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9614 0.9553 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5701 0.2671 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1490 1.0708 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.3075 19.3287 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.125 1.048 Excess relative risk (ERR) 

Probability of Causation (PC) 11.15 51.16 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 499 1616Original ERR/Sv 1.0031 0.5636 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0506 2.1769 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0876 0.0979 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2327 1.1245 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0945 1.1433 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0042 1.0494 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5091 0.0993 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1264 1.1090 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.0885 48.6938 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.027 0.267 Excess relative risk (ERR) 

Probability of Causation (PC) 2.64 21.07 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 499 1616Original ERR/Sv 1.0031 0.5636 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.0506 2.1769 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0876 0.0979 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2327 1.1245 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0945 1.1433 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0042 1.0494 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5091 0.0993 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1264 1.1090 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.0885 48.6938 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.162 1.602 Excess relative risk (ERR) 

Probability of Causation (PC) 13.98 61.56 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1913 1322Original ERR/Sv 2.2812 2.5727 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0891 0.0661 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2809 1.1716 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0717 1.1184 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0708 0.9972 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2308 0.7131 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3452 0.3411 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.7595 18.4663 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.016 0.157 Excess relative risk (ERR) 

Probability of Causation (PC) 1.55 13.58 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 612 1322Original ERR/Sv 1.7270 2.5727 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0598 0.0661 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.3726 1.1716 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2627 1.1184 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9528 0.9972 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8512 0.7131 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3472 0.3411 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 3.1515 18.4663 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.095 0.943 Excess relative risk (ERR) 

Probability of Causation (PC) 8.64 48.53 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 80 372Original ERR/Sv 2.6427 2.5303 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0913 0.1166 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1041 1.0421 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0954 1.1004 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9708 0.9972 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9694 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3303 0.3444 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 5.34375 20.5331 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.022 0.249 Excess relative risk (ERR) 

Probability of Causation (PC) 2.12 19.91 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n4_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E=2-20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 80 372Original ERR/Sv 2.6427 2.5303 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0913 0.1166 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1041 1.0421 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0954 1.1004 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9708 0.9972 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9694 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3303 0.3444 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 10 10 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 5.34375 20.5331 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.130 1.492 Excess relative risk (ERR) 

Probability of Causation (PC) 11.51 59.86 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 135 1907Original ERR/Sv 0.4749 6.8768 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1315 0.0665 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0699 1.2111 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1554 1.0841 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9553 0.9332 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9733 0.9793 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0083 0.8779 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 8.0568 7.0344 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.038 0.484 Excess relative risk (ERR) 

Probability of Causation (PC) 3.69 32.60 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 135 1907Original ERR/Sv 0.4749 6.8768 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1315 0.0665 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0699 1.2111 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1554 1.0841 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9553 0.9332 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9733 0.9793 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0083 0.8779 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 8.0568 7.0344 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.230 2.902 Excess relative risk (ERR) 

Probability of Causation (PC) 18.67 74.38 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1250 134Original ERR/Sv 2.3674 14.8539 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0883 0.0899 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0670 1.0716 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2543 1.0273 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9905 0.9517 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3974 0.3991 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.0575 0.7354 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.15137 5.0472 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.051 0.750 Excess relative risk (ERR) 

Probability of Causation (PC) 4.85 42.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1250 134Original ERR/Sv 2.3674 14.8539 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0883 0.0899 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0670 1.0716 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2543 1.0273 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9905 0.9517 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3974 0.3991 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.0575 0.7354 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.15137 5.0472 Linear Quadratic (1=Yes, 0=No) 

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.306 4.498 Excess relative risk (ERR) 

Probability of Causation (PC) 23.41 81.81 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 351 724Original ERR/Sv 0.5076 0.6082 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2086 3.2598 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0830 0.1079 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1474 1.2603 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0988 1.1178 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9136 0.9834 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3820 0.1950 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1041 1.0805 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.0186 11.676 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.023 0.197 Excess relative risk (ERR) 

Probability of Causation (PC) 2.21 16.47 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 351 724Original ERR/Sv 0.5076 0.6082 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2086 3.2598 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0830 0.1079 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1474 1.2603 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0988 1.1178 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9136 0.9834 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3820 0.1950 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1041 1.0805 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.0186 11.676 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.136 1.183 Excess relative risk (ERR) 

Probability of Causation (PC) 11.96 54.18 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 432 1507Original ERR/Sv 0.4875 0.5911 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2446 2.3776 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0942 0.0824 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0921 1.0788 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1829 1.1847 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9534 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7527 0.8814 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1555 1.1216 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.9871 23.148 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.030 0.285 Excess relative risk (ERR) 

Probability of Causation (PC) 2.93 22.17 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 432 1507Original ERR/Sv 0.4875 0.5911 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2446 2.3776 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0942 0.0824 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0921 1.0788 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1829 1.1847 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9534 0.9811 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7527 0.8814 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1555 1.1216 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.9871 23.148 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.181 1.709 Excess relative risk (ERR) 

Probability of Causation (PC) 15.32 63.09 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 120 734Original ERR/Sv 2.2910 1.7153 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1148 0.1057 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0868 1.0863 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2422 1.1530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9654 0.9371 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2324 1.0421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3409 0.3230 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.7526 9.1656 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.017 0.152 Excess relative risk (ERR) 

Probability of Causation (PC) 1.67 13.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 120 734Original ERR/Sv 2.2910 1.7153 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1148 0.1057 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0868 1.0863 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2422 1.1530 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9654 0.9371 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.2324 1.0421 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3409 0.3230 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1.7526 9.1656 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.102 0.914 Excess relative risk (ERR) 

Probability of Causation (PC) 9.24 47.75 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1522 213Original ERR/Sv 3.0732 2.8221 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0877 0.1003 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0911 1.0678 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0725 1.0548 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9942 1.0118 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8088 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3382 0.3381 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.3902 9.0612 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.023 0.216 Excess relative risk (ERR) 

Probability of Causation (PC) 2.27 17.74 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n5_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons E>20MeVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1522 213Original ERR/Sv 3.0732 2.8221 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0877 0.1003 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0911 1.0678 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0725 1.0548 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9942 1.0118 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8088 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3382 0.3381 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 5 5 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 2.3902 9.0612 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.139 1.294 Excess relative risk (ERR) 

Probability of Causation (PC) 12.23 56.41 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1032 663Original ERR/Sv 2.1918 7.4491 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0905 0.0843 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2653 1.1689 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1221 1.0864 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0117 1.0701 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0341 0.6917 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0259 1.0236 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.28537 20.1747 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.034 0.376 Excess relative risk (ERR) 

Probability of Causation (PC) 3.33 27.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1032 663Original ERR/Sv 2.1918 7.4491 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0905 0.0843 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2653 1.1689 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1221 1.0864 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0117 1.0701 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0341 0.6917 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0259 1.0236 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 6.28537 20.1747 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.207 2.254 Excess relative risk (ERR) 

Probability of Causation (PC) 17.13 69.27 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 836 1626Original ERR/Sv 2.5544 6.3428 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0757 0.0808 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1588 1.0814 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0119 1.1014 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9422 0.9921 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3507 0.1554 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9764 0.8376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.04463 37.6875 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.045 0.598 Excess relative risk (ERR) 

Probability of Causation (PC) 4.30 37.41 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 836 1626Original ERR/Sv 2.5544 6.3428 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0757 0.0808 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1588 1.0814 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0119 1.1014 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9422 0.9921 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3507 0.1554 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.9764 0.8376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 7.04463 37.6875 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.270 3.586 Excess relative risk (ERR) 

Probability of Causation (PC) 21.25 78.19 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 489 373Original ERR/Sv 0.5552 0.6401 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7826 3.4286 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0622 0.1128 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1836 1.1025 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2389 1.1238 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0387 0.9770 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0361 0.5190 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1376 1.1051 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.5991 27.15 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.144 Excess relative risk (ERR) 

Probability of Causation (PC) 2.03 12.58 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 489 373Original ERR/Sv 0.5552 0.6401 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7826 3.4286 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0622 0.1128 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1836 1.1025 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2389 1.1238 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0387 0.9770 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0361 0.5190 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1376 1.1051 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.5991 27.15 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.124 0.863 Excess relative risk (ERR) 

Probability of Causation (PC) 11.06 46.33 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 350 1056Original ERR/Sv 0.4610 1.2579 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8914 1.9648 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0721 0.1035 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0859 1.0797 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2557 1.0394 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9551 1.0406 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5228 0.8622 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0910 1.0618 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 9.49538 36.6631 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.027 0.216 Excess relative risk (ERR) 

Probability of Causation (PC) 2.65 17.75 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 350 1056Original ERR/Sv 0.4610 1.2579 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8914 1.9648 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0721 0.1035 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0859 1.0797 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2557 1.0394 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9551 1.0406 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5228 0.8622 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.0910 1.0618 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 9.49538 36.6631 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.163 1.295 Excess relative risk (ERR) 

Probability of Causation (PC) 14.02 56.43 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 205 740Original ERR/Sv 1.9055 2.9033 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0706 0.1097 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2542 1.1928 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2060 1.2065 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9764 0.9599 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8391 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3492 0.3399 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 14.054 23.3554 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.017 0.122 Excess relative risk (ERR) 

Probability of Causation (PC) 1.67 10.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 205 740Original ERR/Sv 1.9055 2.9033 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0706 0.1097 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2542 1.1928 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2060 1.2065 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9764 0.9599 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8391 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3492 0.3399 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 14.054 23.3554 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.102 0.730 Excess relative risk (ERR) 

Probability of Causation (PC) 9.23 42.21 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 666 389Original ERR/Sv 2.8030 3.5858 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1072 0.0661 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0976 1.0389 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1957 1.0720 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9651 1.0083 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8781 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3507 0.3309 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.2037 23.7564 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.022 0.186 Excess relative risk (ERR) 

Probability of Causation (PC) 2.14 15.66 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_n6_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type neutrons (fission)Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 666 389Original ERR/Sv 2.8030 3.5858 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1072 0.0661 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0976 1.0389 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1957 1.0720 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9651 1.0083 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.8781 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3507 0.3309 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 10.2037 23.7564 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.132 1.114 Excess relative risk (ERR) 

Probability of Causation (PC) 11.62 52.70 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 786 1061Original ERR/Sv 1.6708 9.9749 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0999 0.1006 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2358 1.3108 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1451 1.1416 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9996 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0293 0.5228 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8749 0.9554 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 27.0908 43.9488 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.057 1.096 Excess relative risk (ERR) 

Probability of Causation (PC) 5.35 52.29 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 786 1061Original ERR/Sv 1.6708 9.9749 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0999 0.1006 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2358 1.3108 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1451 1.1416 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9996 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0293 0.5228 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8749 0.9554 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 27.0908 43.9488 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.339 6.576 Excess relative risk (ERR) 

Probability of Causation (PC) 25.34 86.80 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 786 1061Original ERR/Sv 1.6708 9.9749 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0999 0.1006 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2358 1.3108 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1451 1.1416 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9996 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0293 0.5228 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8749 0.9554 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 27.0908 43.9488 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.057 1.096 Excess relative risk (ERR) 

Probability of Causation (PC) 5.35 52.29 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Thyroid Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 786 1061Original ERR/Sv 1.6708 9.9749 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0999 0.1006 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2358 1.3108 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1451 1.1416 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9996 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0293 0.5228 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.8749 0.9554 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 2 1 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 27.0908 43.9488 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.339 6.576 Excess relative risk (ERR) 

Probability of Causation (PC) 25.34 86.80 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.030 0.373 Excess relative risk (ERR) 

Probability of Causation (PC) 2.94 27.16 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.182 2.238 Excess relative risk (ERR) 

Probability of Causation (PC) 15.38 69.11 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.030 0.373 Excess relative risk (ERR) 

Probability of Causation (PC) 2.94 27.16 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Colon Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alpha

Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1340 1578Original ERR/Sv 0.6137 0.1953 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.8105 2.3685 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0749 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2032 1.1181 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1500 1.2571 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9499 1.0063 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0248 0.7791 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.1054 1.1194 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 3 0.7 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 25.8258 285.559 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.182 2.238 Excess relative risk (ERR) 

Probability of Causation (PC) 15.38 69.11 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alpha

Parametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 682 1506Original ERR/Sv 2.0608 2.4894 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0847 0.0875 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1582 1.2008 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1570 1.1528 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0564 0.9323 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9337 0.9892 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3254 0.3376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 4 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 29.3727 101.832 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.028 0.354 Excess relative risk (ERR) 

Probability of Causation (PC) 2.69 26.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_10

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate acute Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 682 1506Original ERR/Sv 2.0608 2.4894 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0847 0.0875 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1582 1.2008 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1570 1.1528 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0564 0.9323 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9337 0.9892 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3254 0.3376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 4 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 29.3727 101.832 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.166 2.121 Excess relative risk (ERR) 

Probability of Causation (PC) 14.25 67.96 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_11

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 682 1506Original ERR/Sv 2.0608 2.4894 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0847 0.0875 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1582 1.2008 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1570 1.1528 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0564 0.9323 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9337 0.9892 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3254 0.3376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 4 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 5 5 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 29.3727 101.832 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.028 0.354 Excess relative risk (ERR) 

Probability of Causation (PC) 2.69 26.12 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier DDREF_a_12

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Breast Attained age Exposure Information Exposure year 1920 Exposure rate chronic Radiation type alphaParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 682 1506Original ERR/Sv 2.0608 2.4894 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0847 0.0875 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1582 1.2008 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1570 1.1528 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0564 0.9323 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9337 0.9892 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3254 0.3376 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 4 1.5 adjusted for DDREF Organ equivalent dose (cSv)c 30 30 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 20 20 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 29.3727 101.832 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.166 2.121 Excess relative risk (ERR) 

Probability of Causation (PC) 14.25 67.96 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix F 

Effect of Ethnic Origin on the ERR per Unit Dose for Skin Cancer 

The calculations documented in this appendix were performed to verify that the 

adjustment accounting for the interaction between ionizing and UV radiation for 

individuals of different ethnic origins is implemented correctly in NIOSH-IREP. A total 

of 15 calculations was performed for this specific verification task. 

The calculations performed for this exercise assume an acute exposure to high 

energy photons (E>250 keV), the age at exposure (AAE) was kept constant at 20 years, 

and the attained age (ATA) was kept constant at 40 years. The verification calculations 

were performed for males only under the assumption of a single acute exposure to a dose 

of 20 cSv. 

Further details about this verification task can be found in Section 5.5 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

This page was intentionally left blank. 
Verification Run Identifier Ethnic_MM_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Ethnic Origin American IndianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1765 1049Original ERR/Sv 6.5583 7.7109 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0698 0.0898 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0539 1.3507 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1616 1.1749 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9546 0.9325 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3199 0.5910 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.6958 8.3440 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.952 4.547 Excess relative risk (ERR) 

Probability of Causation (PC) 48.78 81.97 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_MM_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Ethnic Origin AsianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 98 1149

Original ERR/Sv 7.0486 14.5782 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0821 0.0902 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1636 1.1357 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0992 1.0782 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0096 1.0024 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5327 1.0293 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.2600 0.3635 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.773 2.638 Excess relative risk (ERR) 

Probability of Causation (PC) 43.59 72.51 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_MM_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Ethnic Origin BlackExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1025 912Original ERR/Sv 6.4498 16.6240 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1108 0.1214 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0572 1.0955 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1545 1.1504 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0036 1.0100 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5146 0.4920 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 0.4303 0.8584 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.846 2.719 Excess relative risk (ERR) 

Probability of Causation (PC) 45.84 73.11 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_MM_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Ethcni Origin HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1291 409Original ERR/Sv 6.4430 14.7888 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0673 0.0783 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0263 1.1418 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2047 1.1142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9811 1.0277 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.3787 1.0549 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.2472 0.1370 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.604 2.555 Excess relative risk (ERR) 

Probability of Causation (PC) 37.64 71.87 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_MM_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Malignant melanoma Attained age Ethnic Origin White non-HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 423 1325Original ERR/Sv 4.3731 16.1408 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0727 0.0817 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0643 1.0561 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1357 1.0828 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0143 0.9595 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6251 0.7731 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0328 0.0382 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.488 2.488 Excess relative risk (ERR) 

Probability of Causation (PC) 32.79 71.33 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_BCC_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Ethnic Origin American IndianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 695Original ERR/Sv 6.8480 21.5451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0936 0.1004 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.4442 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.7002 1.9241 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.323 5.457 Excess relative risk (ERR) 

Probability of Causation (PC) 56.95 84.51 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_BCC_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Ethnic Origin AsianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 695Original ERR/Sv 6.8480 21.5451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0936 0.1004 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.4442 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.7002 1.9241 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.323 5.457 Excess relative risk (ERR) 

Probability of Causation (PC) 56.95 84.51 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_BCC_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Ethnic Origin BlackExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1342 695Original ERR/Sv 6.8480 21.5451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0936 0.1004 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0515 1.1203 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.1700 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9619 1.0036 multiplicative risk model 

 Model Mixture factor for transfer to US pop 1.0013 0.4442 additive risk model  Ratio of Japanese to U.S. baseline cancer rates 1.7002 1.9241 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 1.323 5.457 Excess relative risk (ERR) 

Probability of Causation (PC) 56.95 84.51 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_BCC_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Ethnic Origin HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1740 371Original ERR/Sv 5.7313 13.2732 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0948 0.0947 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1507 1.0902 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1377 1.0519 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0181 0.9277 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5025 0.9100 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.1204 0.1027 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.529 2.512 Excess relative risk (ERR) 

Probability of Causation (PC) 34.62 71.52 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_BCC_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (BCC) Attained age 

Ethnic Origin While non-HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 15 1430

Original ERR/Sv 4.5614 13.4140 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0853 0.0587 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1193 1.1511 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2012 1.0334 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9865 0.9946 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.6356 1.0471 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0215 0.0203 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF 

Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.480 2.511 Excess relative risk (ERR) 

Probability of Causation (PC) 32.45 71.52 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_SCC_1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Ethnic Origin American IndianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 124

Original ERR/Sv -0.1915 0.8683 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1452 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1605 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.1378 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.7100 0.9269 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.139 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 12.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_SCC_2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Ethnic Origin AsianExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 124

Original ERR/Sv -0.1915 0.8683 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1452 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1605 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.1378 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.7100 0.9269 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.139 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 12.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_SCC_3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Ethnic Origin BlackExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 124

Original ERR/Sv -0.1915 0.8683 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0894 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1452 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1605 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9577 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.1378 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 1.7100 0.9269 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.139 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 12.22 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_SCC_4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Ethnic Origin HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 409

Original ERR/Sv -0.1915 0.3996 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0901 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1418 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.1142 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 1.0277 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 1.0549 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0995 0.0799 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.070 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 6.54 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Ethnic_SCC_5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Non-melanoma (SCC) Attained age 

Ethnic Origin White non-HispanicExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1 1945

Original ERR/Sv -0.1915 0.4633 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0865 0.0821 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1934 1.1230 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0294 1.0286 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9363 0.9589 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7027 0.7560 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.0189 0.0213 Smoking history 1 1 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.000 0.069 Excess relative risk (ERR) 

Probability of Causation (PC) 0.00 6.45 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix G 

Effect of Cigarette Smoking on the Risk of Lung Cancer (Non-radon Exposures) 

The calculations documented in this appendix were performed to ensure that the 

interaction effect between smoking and radiation exposures (non-radon) has been 

properly programmed in NIOSH-IREP for estimating the risk of lung cancer. A total of 

14 calculations was performed for this specific verification task. 

Both models to estimate risk for lung cancer due to sources of exposure other than 

radon (the NIH lung model and the pre-2006 NIOSH lung model) take into account an 

interaction between radiation and smoking history. The calculations have been 

performed to test the combined lung model and report the 99th percentile PC value that is 

the largest. 

Calculations were performed separately for males and females and assume an 

acute exposure to 20 cSv of high energy photons, E > 250 keV. The age at exposure 

(AAE) was kept constant at 20 years of age, and the attained age (ATA) was kept 

constant at 40 years of age. 

Further details about this verification task can be found in Section 5.6 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

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Verification Run Identifier Lung_other_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedLung model used for calculation NIOSH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 720 1305Original ERR/Sv 0.6477 0.7451 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1168 0.0928 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0722 1.1818 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1975 1.0316 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0342 0.9563 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.1956 0.7841 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7358 0.7121 Smoking history 1.475203 3.548618 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.127 0.465 Excess relative risk (ERR) 

Probability of Causation (PC) 11.24 31.74 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Former smokerLung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 280 1591Original ERR/Sv 1.3769 1.1800 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7843 1.8577 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0929 0.1048 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0611 1.2085 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1830 1.0301 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0611 1.0390 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0053 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7018 0.7208 Smoking history 0.2511 0.835326 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.071 0.313 Excess relative risk (ERR) 

Probability of Causation (PC) 6.63 23.85 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Current smoker (? cig/day)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1796 168Original ERR/Sv 1.1319 1.4015 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.2554 1.6119 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1180 0.0944 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2020 1.1366 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1182 1.0434 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0387 1.0168 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.7626 0.2720 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7000 0.7067 Smoking history 0.08861 0.944771 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.021 0.102 Excess relative risk (ERR) 

Probability of Causation (PC) 3.26 23.35 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History <10 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 9 1591

Original ERR/Sv 1.1671 1.1800 Original ERR/Sv 

Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 0.8492 1.8577 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0691 0.1048 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1168 1.2085 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2330 1.0301 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0267 1.0390 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0053 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7459 0.7208 Smoking history 0.643891 0.836711 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.074 0.087 Excess relative risk (ERR) 

Probability of Causation (PC) 6.72 23.88 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 10-19 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 31 488Original ERR/Sv 1.8611 1.4669 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4695 1.7637 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1032 0.0922 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1297 1.1780 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2574 1.0604 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9979 1.0121 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.4123 0.3067 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7368 0.7205 Smoking history 0.1034 0.847862 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.080 0.062 Excess relative risk (ERR) 

Probability of Causation (PC) 3.59 23.41 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1625 525Original ERR/Sv 0.4357 1.3657 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.7414 2.2395 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0630 0.0687 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0860 1.2143 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2007 1.2437 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9875 1.0760 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.6840 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.7318 0.6999 Smoking history 0.258283 0.83471 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.073 0.081 Excess relative risk (ERR) 

Probability of Causation (PC) 2.31 23.31 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_m7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History >40 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 346 525Original ERR/Sv 1.2640 1.3657 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.4803 2.2395 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0994 0.0687 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1566 1.2143 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2016 1.2437 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0047 1.0760 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.6840 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.6941 0.6999 Smoking history 0.08984 0.831744 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.049 0.303 Excess relative risk (ERR) 

Probability of Causation (PC) 1.80 23.25 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedLung model used for calculation NIOSH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 485 132Original ERR/Sv 1.6814 2.7666 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 1.0000 1.0000 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0923 0.0715 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1067 1.0356 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1249 1.1335 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9881 0.9714 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.5503 1.0184 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3777 0.3659 Smoking history 1.710404 2.426341 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.368 1.276 Excess relative risk (ERR) 

Probability of Causation (PC) 26.89 56.07 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Former smokerLung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 270 42Original ERR/Sv 0.5407 0.8124 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 4.4025 4.9982 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1325 0.0791 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2626 1.2347 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.2389 1.0653 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9486 1.0468 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 0.9568 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3638 0.3714 Smoking history 0.785756 1.063091 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.185 0.369 Excess relative risk (ERR) 

Probability of Causation (PC) 9.41 39.69 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Current smoker (? cig/day)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 360 521Original ERR/Sv 0.3161 1.0684 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.9253 6.3926 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0973 0.1061 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.0898 1.3439 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0529 1.0717 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0342 0.9618 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0071 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3610 0.3656 Smoking history 0.657158 0.5805 adjusted for smoking history 

 Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.167 0.636 Excess relative risk (ERR) 

Probability of Causation (PC) 5.16 38.88 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History <10 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 55 42Original ERR/Sv 0.6129 0.8124 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.7965 4.9982 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1112 0.0791 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1558 1.2347 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0572 1.0653 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9282 1.0468 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.8556 0.9568 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3506 0.3714 Smoking history 0.2564 1.062662 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.214 0.658 Excess relative risk (ERR) 

Probability of Causation (PC) 9.58 39.68 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 10-19 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 1003 521Original ERR/Sv 0.7013 1.0684 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 2.9582 6.3926 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.1264 0.1061 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.2365 1.3439 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0555 1.0717 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 1.0428 0.9618 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.0000 1.0071 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3311 0.3656 Smoking history 0.538526 0.587579 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.070 0.145 Excess relative risk (ERR) 

Probability of Causation (PC) 5.77 39.16 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f6

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 896 525Original ERR/Sv 1.1974 1.3657 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 3.5961 5.2653 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0720 0.0687 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1483 1.2143 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.0825 1.2437 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9921 1.0760 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9502 0.6840 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3373 0.3648 Smoking history 0.05897 0.834692 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.157 0.631 Excess relative risk (ERR) 

Probability of Causation (PC) 4.09 38.69 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_other_f7

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History >40 cig/day (currently)Lung model used for calculation NIH-IREPExposure Information Exposure year 1920 Exposure rate acute Radiation type photons E>250keVParametera Midd Upperd Intermediate results calculated in Exce

Monte Carlo iteration number 761 525Original ERR/Sv 1.0654 1.3657 Original ERR/Sv Adjustment Factors ERR/Sv with adjustments Age at exposure, Attained age 4.6183 5.2653 w/ age adjustment 

 Minimum latency for cancer induction 1.0000 1.0000 w/ latency adjustment 

 Random errors in dosesb 0.0935 0.0687 w/ random errors in dosimetry adj 

 Systematic errors in gamma dosesb 1.1760 1.2143 w/ systematic errors in dosimetry adj  Systematic errors in neutron dosesb 1.1878 1.2437 adjusted for population transfer 

 Systematic errors in RBE neutron dosesb 0.9682 1.0760 multiplicative risk model 

 Model Mixture factor for transfer to US pop 0.9986 0.6840 additive risk model 

 Ratio of Japanese to U.S. baseline cancer rates 0.3607 0.3648 Smoking history 0.04103 0.831541 adjusted for smoking history  Dose and dose rate effectiveness factor (DDREF) 1 1 adjusted for DDREF Organ equivalent dose (cSv)c 20 20 Final ERR/Sv 

 Radiation weighting factor (wR - ICRP 60) 1 1 Organ equivalent dose (Sv) 

 Radiation effectiveness factor (REF) 1 1 Linear Quadratic (1=Yes, 0=No) Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.109 0.328 Excess relative risk (ERR) 

Probability of Causation (PC) 3.16 38.60 Probability of Causation (PC) 

a Listed values that produce the 50th and 99th percentiles of PC reported by NIOSH-IREP, respectivelyb Doses to the Japanese atomic bomb survivorsc Dose assigned to the claimantd Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix H 

Effect of Cigarette Smoking on the Risk of Lung Cancer from Radon Exposures 

The calculations documented in this appendix were performed to ensure that the 

interaction effect between smoking and radon exposures has been properly programmed 

in NIOSH-IREP for estimating the risk of lung cancer. A total of 36 calculations was 

performed for this specific verification task. 

Although the radon risk model used in NIOSH-IREP is assumed to be 

independent of gender, calculations were performed separately for males and females, for 

purposes of verification. 

Smoking history was defined as “never smoked” (to represent a nonsmoker) or 

having a smoking history of between 20 and 39 cigarettes per day (to represent a 

smoker). The age at exposure (AAE) was varied between 20 and 75 years, while the 

attained age (ATA) was varied between 40 and 80 years. All calculations assume a radon 

exposure of 1 Working Level Month (WLM). 

Further details about this verification task can be found in Section 5.7 of the 

report. The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
This page was intentionally left blank. 

 
Verification Run Identifier Lung_radon_ns_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 336 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0723 0.6827 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3241 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.287 2.818 Excess relative risk (ERR) 

Probability of Causation (PC) 22.32 73.81 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1935Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 213 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.5800 2.5024 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0246 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.1765 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.098 2.244 Excess relative risk (ERR) 

Probability of Causation (PC) 8.95 69.17 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 1688 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0095 0.0655 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.1607 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.033 0.231 Excess relative risk (ERR) 

Probability of Causation (PC) 3.21 18.75 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 362 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0141 0.1113 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3703 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.058 0.392 Excess relative risk (ERR) 

Probability of Causation (PC) 5.47 28.18 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1955Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 943 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0781 0.3884 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0344 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.3381 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.020 0.348 Excess relative risk (ERR) 

Probability of Causation (PC) 1.94 25.83 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.007 0.052 Excess relative risk (ERR) 

Probability of Causation (PC) 0.67 4.93 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.007 0.052 Excess relative risk (ERR) 

Probability of Causation (PC) 0.67 4.93 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1960Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 698 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0038 0.0217 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.0267 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.012 0.090 Excess relative risk (ERR) 

Probability of Causation (PC) 1.16 8.23 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_ns_m9

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1975Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 779 1948Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0197 0.0447 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0249 0.4385 ERR - nonsmoker 

 Random errors in dosimetry 1.3574 1.1934

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.004 0.081 Excess relative risk (ERR) 

Probability of Causation (PC) 0.39 7.53 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier Lung_radon_sm_m1

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 336 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0723 0.6827 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3241 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.077 0.751 Excess relative risk (ERR) 

Probability of Causation (PC) 7.12 42.91 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m2

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1935Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 213 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.5800 2.5024 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0246 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.1765 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.026 0.598 Excess relative risk (ERR) 

Probability of Causation (PC) 2.55 37.44 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m3

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 1688 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0095 0.0655 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.1607 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.009 0.062 Excess relative risk (ERR) 

Probability of Causation (PC) 0.88 5.80 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m4

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 362 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0141 0.1113 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3703 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.015 0.105 Excess relative risk (ERR) 

Probability of Causation (PC) 1.52 9.47 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m5

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1955Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 943 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0781 0.3884 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0344 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.3381 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.005 0.093 Excess relative risk (ERR) 

Probability of Causation (PC) 0.53 8.50 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m6

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.002 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.18 1.36 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m7

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.002 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.18 1.36 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m8

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1960Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 698 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0038 0.0217 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.0267 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.003 0.024 Excess relative risk (ERR) 

Probability of Causation (PC) 0.31 2.34 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_m9

Personal Information Personal Information

 Gender Male Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1975Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 779 1948Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0197 0.0447 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0249 0.4385 ERR - nonsmoker 

 Random errors in dosimetry 1.3574 1.1934

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.001 0.022 Excess relative risk (ERR) 

Probability of Causation (PC) 0.10 2.12 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 336 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0723 0.6827 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3241 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.287 2.818 Excess relative risk (ERR) 

Probability of Causation (PC) 22.32 73.81 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1935Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 213 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.5800 2.5024 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0246 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.1765 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.098 2.244 Excess relative risk (ERR) 

Probability of Causation (PC) 8.95 69.17 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 1688 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0095 0.0655 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.1607 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.033 0.231 Excess relative risk (ERR) 

Probability of Causation (PC) 3.21 18.75 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 362 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0141 0.1113 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3703 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.058 0.392 Excess relative risk (ERR) 

Probability of Causation (PC) 5.47 28.18 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1955Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 943 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0781 0.3884 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0344 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.3381 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.020 0.348 Excess relative risk (ERR) 

Probability of Causation (PC) 1.94 25.83 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f6

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.007 0.052 Excess relative risk (ERR) 

Probability of Causation (PC) 0.67 4.93 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f7

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.007 0.052 Excess relative risk (ERR) 

Probability of Causation (PC) 0.67 4.93 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f8

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1960Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 698 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0038 0.0217 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.0267 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.012 0.090 Excess relative risk (ERR) 

Probability of Causation (PC) 1.16 8.23 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_ns_f9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History Never smokedExposure Information Exposure year 1975Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 779 1948Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0197 0.0447 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0249 0.4385 ERR - nonsmoker 

 Random errors in dosimetry 1.3574 1.1934

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.004 0.081 Excess relative risk (ERR) 

Probability of Causation (PC) 0.39 7.53 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f1

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 336 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0723 0.6827 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3241 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.077 0.751 Excess relative risk (ERR) 

Probability of Causation (PC) 7.12 42.91 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f2

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1940 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1935Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 213 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.5800 2.5024 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0246 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.1765 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.026 0.598 Excess relative risk (ERR) 

Probability of Causation (PC) 2.55 37.44 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f3

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 1688 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0095 0.0655 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.1607 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.009 0.062 Excess relative risk (ERR) 

Probability of Causation (PC) 0.88 5.80 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f4

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 362 623Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0141 0.1113 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.3703 1.1750

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.015 0.105 Excess relative risk (ERR) 

Probability of Causation (PC) 1.52 9.47 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f5

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1960 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1955Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 943 244Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0781 0.3884 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0344 0.1744 ERR - nonsmoker 

 Random errors in dosimetry 1.3381 1.2502

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.005 0.093 Excess relative risk (ERR) 

Probability of Causation (PC) 0.53 8.50 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f6

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1920Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.002 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.18 1.36 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f7

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1940Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 5 1591

Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) 

ERR at 1 WLM 0.0018 0.0126 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.2676 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.002 0.014 Excess relative risk (ERR) 

Probability of Causation (PC) 0.18 1.36 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f8

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1960Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 698 1591Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0038 0.0217 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 1.0000 1.0000 ERR - nonsmoker 

 Random errors in dosimetry 1.0267 1.3760

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.003 0.024 Excess relative risk (ERR) 

Probability of Causation (PC) 0.31 2.34 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Verification Run Identifier lung_radon_sm_f9

Personal Information Personal Information

 Gender Female Birth year 1900 Diagnosis year 1980 Age at exposure 

 Cancer Lung Attained age Smoking History 20-39 cig/day (currently)Exposure Information Exposure year 1975Parametera Midb Upperb Intermediate results calculated in Exce

Monte Carlo iteration number 779 1948Unadjusted Radon Exposure (WLM) 1.0000 1.0000 Unadjusted Radon Exposure (WLM) ERR at 1 WLM 0.0197 0.0447 WLM with latency adjustment Adjustment Factors ERR - smoker  Minimum latency for cancer induction 0.0249 0.4385 ERR - nonsmoker 

 Random errors in dosimetry 1.3574 1.1934

Final results calculated by NIOSH-IREP Final results calculated in ExcelExcess relative risk (ERR) 0.001 0.022 Excess relative risk (ERR) 

Probability of Causation (PC) 0.10 2.12 Probability of Causation (PC) 

a Listed values of each parameter are for the iteration that is the closest to the 50th and 99th percentiles of PC reported by Nb Mid and upper values are representative of the iteration closest to the 50th and 99th percentile, respectively

Values Reported by NIOSH-IREP v.5.5.3r Verification Calculations u
Appendix I 

Verification of the Implementation of Multiple Exposures Algorithms 

A series of 5 calculations has been performed to ensure that NIOSH-IREP 

properly estimates PC in cases involving multiple radiation exposures. 

Various combinations of gender, cancer type, age at time of exposure, time 

exposure and diagnosis, organ dose, exposure rate, and radiation type were chosen. Five 

exposures were assumed for the first 4 scenarios and three exposures were assumed for 

the 5th scenario. 

The results for ERR and PC obtained with MS Excel verify the mid and upper 

bound values of ERR and PC estimated using NIOSH-IREP v.5.5.3r, for all exposure 

scenarios considered. 

 
 

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Verification Run Identifier Mult Exp 1

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Colon Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1921 1922 1923 

 Age at exposure 20 21 22 23 

 Exposure rate acute chronic acute chronic 

 Radiation type photons E<30keV photons E=30- 250keV electrons E<15keV neutrons E<10keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 50th percentile 320 320 320 320 Original ERR/Sv, correlated w/ age adjustment 0.8082 0.7563 0.7352 0.6965 

Adjustment Factors Age at exposure, Attained age 1.8147 1.5180 1.6626 1.2128 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.0712 0.0712 0.0712 0.0712 

 Systematic errors in gamma dosesa 1.3201 1.3201 1.3201 1.3201  Systematic errors in neutron dosesa 1.1150 1.1150 1.1150 1.1150  Systematic errors in RBE neutron dosesa 1.0064 1.0064 1.0064 1.0064  Model Mixture factor for transfer to US pop 0.1345 0.1345 0.1345 0.1345  Ratio of Japanese to U.S. baseline cancer rates 1.0996 1.0996 1.0996 1.0996  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1 2 1.01633 1 

Organ equivalent dose (cSv)b 5 5 5 5 

 Radiation weighting factor (wR - ICRP 60) 1 1 1 5 

 Radiation effectiveness factor (REF) 4.48112 3.19825 2.10526 2.14823 

Final results calculated by NIOSH-IREP Midpointc

Excess relative risk (ERR) 0.282Probability of Causation (PC) 21.99

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Midpoint values are representative of the iteration closest to the 50th percentile

Midpoint Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 1

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Colon Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1921 1922 1923 

 Age at exposure 20 21 22 23 

 Exposure rate acute chronic acute chronic  Radiation type photons E<30keV photons E=30- 250keV electrons E<15keV neutrons E<10keV Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 0.8082 0.7563 0.7352 0.6965 

 w/ latency adjustment 0.8082 0.7563 0.7352 0.6965 

 w/ random errors in dosimetry adj 0.8657 0.8102 0.7876 0.7461 

 w/ systematic errors in dosimetry adj 0.5845 0.5470 0.5317 0.5037 

 adjusted for population transfer 0.6349 0.5941 0.5776 0.5471 

 multiplicative risk model 0.5845 0.5470 0.5317 0.5037 

 additive risk model 0.6427 0.6015 0.5847 0.5539 

 adjusted for smoking history 0.6349 0.5941 0.5776 0.5471 

 adjusted for DDREF 0.6349 0.2971 0.5683 0.5471 

ERR/Sv 0.6349 0.2971 0.5683 0.5471 

Organ equivalent dose (Sv) 0.224056 0.1599125 0.105263 0.0214823 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.142 0.048 0.060 0.012 

Final results calculated in Excel Midpointc

Total Excess relative risk (ERR) 0.282Probability of Causation (PC) 21.99

c Midpoint values are representative of the iteration closest to the 50th percentile

Verification of Midpoint Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 1

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Colon Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1921 1922 1923 

 Age at exposure 20 21 22 23 

 Exposure rate acute chronic acute chronic 

 Radiation type photons E<30keV photons E=30- 250keV electrons E<15keV neutrons E<10keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 99th percentile 1393 1393 1393 1393 

Original ERR/Sv, correlated w/ age adjustment 2.0772 1.9272 1.7939 1.7047 

Adjustment Factors Age at exposure, Attained age 1.5027 1.4570 1.2892 1.5483 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.1161 0.1161 0.1161 0.1161 

 Systematic errors in gamma dosesa 1.2939 1.2939 1.2939 1.2939  Systematic errors in neutron dosesa 1.1460 1.1460 1.1460 1.1460  Systematic errors in RBE neutron dosesa 0.9256 0.9256 0.9256 0.9256  Model Mixture factor for transfer to US pop 0.0058 0.0058 0.0058 0.0058  Ratio of Japanese to U.S. baseline cancer rates 1.1628 1.1628 1.1628 1.1628  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1 2 1 1 Organ equivalent dose (cSv)b 5 5 5 5 

 Radiation weighting factor (wR - ICRP 60) 1 1 1 5 

 Radiation effectiveness factor (REF) 5.06452 3.71541 2.75385 6.8652 

Final results calculated by NIOSH-IREP Upperc

Excess relative risk (ERR) 1.047Probability of Causation (PC) 51.16

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Upper values are representative of the iteration closest to the 99th percentile

Upper Bound Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 1

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Colon Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1921 1922 1923 

 Age at exposure 20 21 22 23 

 Exposure rate acute chronic acute chronic  Radiation type photons E<30keV photons E=30- 250keV electrons E<15keV neutrons E<10keV Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 2.0772 1.9272 1.7939 1.7047 

 w/ latency adjustment 2.0772 1.9272 1.7939 1.7047 

 w/ random errors in dosimetry adj 2.3183 2.1509 2.0022 1.9026 

 w/ systematic errors in dosimetry adj 1.6891 1.5671 1.4588 1.3862 

 adjusted for population transfer 1.9624 1.8207 1.6948 1.6105 

 multiplicative risk model 1.6891 1.5671 1.4588 1.3862 

 additive risk model 1.9640 1.8222 1.6962 1.6118 

 adjusted for smoking history 1.9624 1.8207 1.6948 1.6105 

 adjusted for DDREF 1.9624 0.9103 1.6948 1.6105 

ERR/Sv 1.9624 0.9103 1.6948 1.6105 

Organ equivalent dose (Sv) 0.253226 0.1857705 0.1376925 0.068652 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.497 0.169 0.233 0.111 

Final results calculated in Excel Upperc

Total Excess relative risk (ERR) 1.047Probability of Causation (PC) 51.16

c Upper values are representative of the iteration closest to the 99th percentile

Verification of Upper Bound Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 2

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1945 Cancer Breast Attained age 45Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1925 1930 1935 

 Age at exposure 20 25 30 35 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV electrons E>15keV alpha neutrons E=10-100keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 50th percentile 551 551 551 551 Original ERR/Sv, correlated w/ age adjustment 1.9495 1.6302 1.3803 1.3803 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 0.9999 0.9211  Random errors in dosesa 0.0910 0.0910 0.0910 0.0910 

 Systematic errors in gamma dosesa 1.2837 1.2837 1.2837 1.2837  Systematic errors in neutron dosesa 1.1098 1.1098 1.1098 1.1098  Systematic errors in RBE neutron dosesa 0.9846 0.9846 0.9846 0.9846  Model Mixture factor for transfer to US pop 0.0476 0.0476 0.0476 0.0476  Ratio of Japanese to U.S. baseline cancer rates 0.3378 0.3378 0.3378 0.3378  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1 1 1 1 Organ equivalent dose (cSv)b 5 2 10 3 

 Radiation weighting factor (wR - ICRP 60) 1 1 20 10 

 Radiation effectiveness factor (REF) 1 1 17.1051 2.24925 

Final results calculated by NIOSH-IREP Midpointc

Excess relative risk (ERR) 0.074Probability of Causation (PC) 6.87

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Midpoint values are representative of the iteration closest to the 50th percentile

Exposure #

Midpoint Values Reported by NIOSH-IREP v.5.5.3r
Verification Run Identifier Mult Exp 2

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1945 Cancer Breast Attained age 45Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1925 1930 1935 

 Age at exposure 20 25 30 35 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV electrons E>15keV alpha neutrons E=10-100keV 

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 1.9495 1.6302 1.3803 1.3803 

 w/ latency adjustment 1.9495 1.6302 1.3802 1.2714 

 w/ random errors in dosimetry adj 2.1269 1.7785 1.5058 1.3871 

 w/ systematic errors in dosimetry adj 1.5163 1.2679 1.0735 0.9889 

 adjusted for population transfer 0.5600 0.4683 0.3964 0.3652 

 multiplicative risk model 1.5163 1.2679 1.0735 0.9889 

 additive risk model 0.5122 0.4283 0.3626 0.3340 

 adjusted for smoking history 0.5600 0.4683 0.3964 0.3652 

 adjusted for DDREF 0.5600 0.4683 0.3964 0.3652 

ERR/Sv 0.5600 0.4683 0.3964 0.3652 

Organ equivalent dose (Sv) 0.05 0.02 0.0855255 0.00674775 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.028 0.009 0.034 0.002 

Final results calculated in Excel Midpointc

Total Excess relative risk (ERR) 0.074Probability of Causation (PC) 6.87

c Midpoint values are representative of the iteration closest to the 50th percentile

Verification of Midpoint Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 2

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1945 Cancer Breast Attained age 45Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1925 1930 1935 

 Age at exposure 20 25 30 35 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV electrons E>15keV alpha neutrons E=10-100keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 99th percentile 1837 1837 1837 1837 

Original ERR/Sv, correlated w/ age adjustment 2.2782 1.9395 1.7244 1.7244 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 0.9642  Random errors in dosesa 0.0943 0.0943 0.0943 0.0943 

 Systematic errors in gamma dosesa 1.1082 1.1082 1.1082 1.1082  Systematic errors in neutron dosesa 1.0990 1.0990 1.0990 1.0990  Systematic errors in RBE neutron dosesa 0.9332 0.9332 0.9332 0.9332  Model Mixture factor for transfer to US pop 0.5943 0.5943 0.5943 0.5943  Ratio of Japanese to U.S. baseline cancer rates 0.3482 0.3482 0.3482 0.3482  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1 1 1 1 Organ equivalent dose (cSv)b 5 2 10 3 

 Radiation weighting factor (wR - ICRP 60) 1 1 20 10 

 Radiation effectiveness factor (REF) 1 1 54.2287 4.9275 

Final results calculated by NIOSH-IREP Upperc

Excess relative risk (ERR) 0.457Probability of Causation (PC) 31.35

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Upper values are representative of the iteration closest to the 99th percentile

Exposure #

Upper Bound Values Reported by NIOSH-IREP v.5.5.3r
Verification Run Identifier Mult Exp 2

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1945 Cancer Breast Attained age 45Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1925 1930 1935 

 Age at exposure 20 25 30 35 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV electrons E>15keV alpha neutrons E=10-100keV 

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 2.2782 1.9395 1.7244 1.7244 

 w/ latency adjustment 2.2782 1.9395 1.7243 1.6627 

 w/ random errors in dosimetry adj 2.4931 2.1224 1.8869 1.8194 

 w/ systematic errors in dosimetry adj 2.1935 1.8673 1.6601 1.6008 

 adjusted for population transfer 1.6135 1.3736 1.2211 1.1775 

 multiplicative risk model 2.1935 1.8673 1.6601 1.6008 

 additive risk model 0.7637 0.6502 0.5780 0.5574 

 adjusted for smoking history 1.6135 1.3736 1.2211 1.1775 

 adjusted for DDREF 1.6135 1.3736 1.2211 1.1775 

ERR/Sv 1.6135 1.3736 1.2211 1.1775 

Organ equivalent dose (Sv) 0.05 0.02 0.2711435 0.0147825 0 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.081 0.027 0.331 0.017 

Final results calculated in Excel Upperc

Total Excess relative risk (ERR) 0.457Probability of Causation (PC) 31.35

c Upper values are representative of the iteration closest to the 99th percentile

Exposure #

Verification of Upper Bound Values using MS Excel
Verification Run Identifier Mult Exp 3

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1950 Cancer Thyroid Attained age 50Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1922 1924 1926 

 Age at exposure 20 22 24 26 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 50th percentile 331 331 331 331 Original ERR/Sv, correlated w/ age adjustment 1.6726 1.4161 1.1989 1.0155 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.0805 0.0805 0.0805 0.0805 

 Systematic errors in gamma dosesa 1.1863 1.1863 1.1863 1.1863  Systematic errors in neutron dosesa 1.0890 1.0890 1.0890 1.0890  Systematic errors in RBE neutron dosesa 1.0209 1.0209 1.0209 1.0209  Model Mixture factor for transfer to US pop 0.9210 0.9210 0.9210 0.9210  Ratio of Japanese to U.S. baseline cancer rates 1.3271 1.3271 1.3271 1.3271  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 2 1 1 2 

Organ equivalent dose (cSv)b 5 6 8 4 

 Radiation weighting factor (wR - ICRP 60) 1 10 5 1 

 Radiation effectiveness factor (REF) 1 17.5362 3.1565 1.27585 

Final results calculated by NIOSH-IREP Midpointc

Excess relative risk (ERR) 0.288Probability of Causation (PC) 22.39

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Midpoint values are representative of the iteration closest to the 50th percentile

Midpoint Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 3

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1950 Cancer Thyroid Attained age 50Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1922 1924 1926 

 Age at exposure 20 22 24 26 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

E

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 1.6726 1.4161 1.1989 1.0155 

 w/ latency adjustment 1.6726 1.4161 1.1989 1.0155 

 w/ random errors in dosimetry adj 1.6726 1.4161 1.1989 1.0155 

 w/ systematic errors in dosimetry adj 1.6726 1.4161 1.1989 1.0155 

 adjusted for population transfer 1.6726 1.4161 1.1989 1.0155 

 multiplicative risk model 1.6726 1.4161 1.1989 1.0155 

 additive risk model 2.2197 1.8793 1.5912 1.3477 

 adjusted for smoking history 1.6726 1.4161 1.1989 1.0155 

 adjusted for DDREF 0.8363 1.4161 1.1989 0.5078 

ERR/Sv 0.8363 1.4161 1.1989 0.5078 

Organ equivalent dose (Sv) 0.05 0.1052172 0.050504 0.051034 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.042 0.149 0.061 0.026 

Final results calculated in Excel Midpointc

Total Excess relative risk (ERR) 0.288Probability of Causation (PC) 22.39

c Midpoint values are representative of the iteration closest to the 50th percentile

Verification of Midpoint Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 3

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1950 Cancer Thyroid Attained age 50Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1922 1924 1926 

 Age at exposure 20 22 24 26 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 99th percentile 414 414 414 414 Original ERR/Sv, correlated w/ age adjustment 11.6797 10.1482 8.8169 7.5643 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.0872 0.0872 0.0872 0.0872 

 Systematic errors in gamma dosesa 1.0633 1.0633 1.0633 1.0633  Systematic errors in neutron dosesa 1.0795 1.0795 1.0795 1.0795  Systematic errors in RBE neutron dosesa 0.9626 0.9626 0.9626 0.9626  Model Mixture factor for transfer to US pop 0.4398 0.4398 0.4398 0.4398  Ratio of Japanese to U.S. baseline cancer rates 1.1651 1.1651 1.1651 1.1651  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1.5 1 1 1.5 

Organ equivalent dose (cSv)b 5 6 8 4 

 Radiation weighting factor (wR - ICRP 60) 1 10 5 1 

 Radiation effectiveness factor (REF) 1 4.2935 4.51 3.9791 

Final results calculated by NIOSH-IREP Upperc

Excess relative risk (ERR) 2.376Probability of Causation (PC) 70.38

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Upper values are representative of the iteration closest to the 99th percentile

Upper Bound Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 3

Personal Information

 Gender Female Birth year 1900 Diagnosis year 1950 Cancer Thyroid Attained age 50Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1920 1922 1924 1926 

 Age at exposure 20 22 24 26 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

E

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 11.6797 10.1482 8.8169 7.5643 

 w/ latency adjustment 11.6797 10.1482 8.8169 7.5643 

 w/ random errors in dosimetry adj 11.6797 10.1482 8.8169 7.5643 

 w/ systematic errors in dosimetry adj 11.6797 10.1482 8.8169 7.5643 

 adjusted for population transfer 11.6797 10.1482 8.8169 7.5643 

 multiplicative risk model 11.6797 10.1482 8.8169 7.5643 

 additive risk model 13.6076 11.8233 10.2722 8.8129 

 adjusted for smoking history 11.6797 10.1482 8.8169 7.5643 

 adjusted for DDREF 7.7865 10.1482 8.8169 5.0429 

ERR/Sv 7.7865 10.1482 8.8169 5.0429 

Organ equivalent dose (Sv) 0.05 0.025761 0.07216 0.159164 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.389 0.261 0.636 0.803 

Final results calculated in Excel Upperc

Total Excess relative risk (ERR) 2.376Probability of Causation (PC) 70.38

c Upper values are representative of the iteration closest to the 99th percentile

Verification of Upper Bound Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 4

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1970 Cancer Non-melanoma (BCC) Ethnic Origin: White-non-Hisp Attained age 70Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1930 1931 1932 1933 

 Age at exposure 30 31 32 33 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 50th percentile 89 89 89 89 

Original ERR/Sv, correlated w/ age adjustment 1.7710 1.5503 1.3571 1.1880 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.0816 0.0816 0.0816 0.0816 

 Systematic errors in gamma dosesa 1.2892 1.2892 1.2892 1.2892  Systematic errors in neutron dosesa 1.1145 1.1145 1.1145 1.1145  Systematic errors in RBE neutron dosesa 0.9545 0.9545 0.9545 0.9545  Model Mixture factor for transfer to US pop 0.5800 0.5800 0.5800 0.5800  Ratio of Japanese to U.S. baseline cancer rates 0.0179 0.0179 0.0179 0.0179  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 2 1 1 2 Organ equivalent dose (cSv)b 5 6 8 4 

 Radiation weighting factor (wR - ICRP 60) 1 10 5 1 

 Radiation effectiveness factor (REF) 1 4.2425 1.6106 2.36288 

Final results calculated by NIOSH-IREP Midpointc

Excess relative risk (ERR) 0.090Probability of Causation (PC) 8.29

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Midpoint values are representative of the iteration closest to the 50th percentile

Exposure #

Midpoint Values Reported by NIOSH-IREP v.5.5.3r
Verification Run Identifier Mult Exp 4

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1970 Cancer Non-melanoma (BCC) Ethnic Origin: White-non-Hispanic

 Attained age 70Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1930 1931 1932 1933 

 Age at exposure 30 31 32 33 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

E

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 1.7710 1.5503 1.3571 1.1880 

 w/ latency adjustment 1.7710 1.5503 1.3571 1.1880 

 w/ random errors in dosimetry adj 1.9154 1.6767 1.4678 1.2849 

 w/ systematic errors in dosimetry adj 1.3966 1.2226 1.0702 0.9369 

 adjusted for population transfer 0.8206 0.7183 0.6288 0.5504 

 multiplicative risk model 1.3966 1.2226 1.0702 0.9369 

 additive risk model 0.0250 0.0218 0.0191 0.0167 

 adjusted for smoking history 0.8206 0.7183 0.6288 0.5504 

 adjusted for DDREF 0.4103 0.7183 0.6288 0.2752 

ERR/Sv 0.4103 0.7183 0.6288 0.2752 

Organ equivalent dose (Sv) 0.05 0.025455 0.0257696 0.0945152 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.021 0.018 0.016 0.026 

Final results calculated in Excel Midpointc

Total Excess relative risk (ERR) 0.090Probability of Causation (PC) 8.29

c Midpoint values are representative of the iteration closest to the 50th percentile

Verification of Midpoint Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 4

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1970 Cancer Non-melanoma (BCC) Ethnic Origin: White-non-Hisp Attained age 70Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1930 1931 1932 1933 

 Age at exposure 30 31 32 33 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

Parameter 1 2 3 4 

Monte Carlo iteration number for 99th percentile 127 127 127 127 Original ERR/Sv, correlated w/ age adjustment 3.0756 2.7551 2.4680 2.2109 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 1.0000 

 Minimum latency for cancer induction 1.0000 1.0000 1.0000 1.0000  Random errors in dosesa 0.0835 0.0835 0.0835 0.0835 

 Systematic errors in gamma dosesa 1.2728 1.2728 1.2728 1.2728  Systematic errors in neutron dosesa 1.0606 1.0606 1.0606 1.0606  Systematic errors in RBE neutron dosesa 1.0136 1.0136 1.0136 1.0136  Model Mixture factor for transfer to US pop 1.0178 1.0178 1.0178 1.0178  Ratio of Japanese to U.S. baseline cancer rates 0.0225 0.0225 0.0225 0.0225  Smoking history 1 1 1 1  Dose and dose rate effectiveness factor (DDREF) 1.5 1 1 1.5 Organ equivalent dose (cSv)b 5 6 8 4 

 Radiation weighting factor (wR - ICRP 60) 1 10 5 1 

 Radiation effectiveness factor (REF) 1 18.5112 4.815 3.43121 

Final results calculated by NIOSH-IREP Upperc

Excess relative risk (ERR) 0.717Probability of Causation (PC) 41.75

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Upper values are representative of the iteration closest to the 99th percentile

Exposure #

Upper Bound Values Reported by NIOSH-IREP v.5.5.3r
Verification Run Identifier Mult Exp 4

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1970 Cancer Non-melanoma (BCC) Ethnic Origin: White-non-Hispanic

 Attained age 70Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1930 1931 1932 1933 

 Age at exposure 30 31 32 33 

 Exposure rate chronic acute chronic chronic  Radiation type photons E>250keV neutrons E=2-20MeV neutrons E>20MeV photons E<30keV 

E

Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 3.0756 2.7551 2.4680 2.2109 

 w/ latency adjustment 3.0756 2.7551 2.4680 2.2109 

 w/ random errors in dosimetry adj 3.3326 2.9853 2.6742 2.3956 

 w/ systematic errors in dosimetry adj 2.4356 2.1818 1.9544 1.7508 

 adjusted for population transfer 2.4779 2.2196 1.9883 1.7812 

 multiplicative risk model 2.4356 2.1818 1.9544 1.7508 

 additive risk model 0.0549 0.0492 0.0440 0.0395 

 adjusted for smoking history 2.4779 2.2196 1.9883 1.7812 

 adjusted for DDREF 1.6519 2.2196 1.9883 1.1874 

ERR/Sv 1.6519 2.2196 1.9883 1.1874 

Organ equivalent dose (Sv) 0.05 0.1110672 0.07704 0.1372484 

 Linear Quadratic (1=Yes, 0=No) 0 0 0 0 Excess relative risk (ERR) 0.083 0.247 0.153 0.163 

Final results calculated in Excel Upperc

Total Excess relative risk (ERR) 0.717Probability of Causation (PC) 41.75

c Upper values are representative of the iteration closest to the 99th percentile

Exposure #

Verification of Upper Bound Values using MS Excel
Verification Run Identifier Mult Exp 5

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Liver Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1925 1930 1935 ---  Age at exposure 25 30 35 ---  Exposure rate chronic acute chronic ---  Radiation type photons E<30keV photons E=30-250keV photons E>250keV --- 

Parameter 1 2 3 4 

Monte Carlo iteration number for 50th percentile 152 152 152 --- Original ERR/Sv, correlated w/ age adjustment 0.4900 0.3791 0.3791 --- 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 ---  Minimum latency for cancer induction 1.0000 1.0000 1.0000 ---  Random errors in dosesa 0.0850 0.0850 0.0850 --- 

 Systematic errors in gamma dosesa 1.2421 1.2421 1.2421 ---  Systematic errors in neutron dosesa 1.1237 1.1237 1.1237 ---  Systematic errors in RBE neutron dosesa 1.0297 1.0297 1.0297 ---  Model Mixture factor for transfer to US pop 0.2764 0.2764 0.2764 ---  Ratio of Japanese to U.S. baseline cancer rates 8.2964 8.2964 8.2964 ---  Smoking history 1 1 1 --- 

 Dose and dose rate effectiveness factor (DDREF) 2 1 2 --- 

Organ equivalent dose (cSv)b 5 6 8 --- 

 Radiation weighting factor (wR - ICRP 60) 1 1 1 --- 

 Radiation effectiveness factor (REF) 1.63787 1.35786 1 --- 

Final results calculated by NIOSH-IREP Midpointc

Excess relative risk (ERR) 0.313Probability of Causation (PC) 23.86

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Midpoint values are representative of the iteration closest to the 50th percentile

Midpoint Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 5

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Liver Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1925 1930 1935 --- 

 Age at exposure 25 30 35 --- 

 Exposure rate chronic acute chronic --- 

 Radiation type photons E<30keV photons E=30-250keV photons E>250keV --- Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 0.4900 0.3791 0.3791 --- 

 w/ latency adjustment 0.4900 0.3791 0.3791 w/ random errors in dosimetry adj 0.5317 0.4113 0.4113 --- 

 w/ systematic errors in dosimetry adj 0.3700 0.2862 0.2862 --- 

 adjusted for population transfer 2.3232 1.7972 1.7972 --- 

 multiplicative risk model 0.3700 0.2862 0.2862 --- 

 additive risk model 3.0694 2.3745 2.3745 --- 

 adjusted for smoking history 2.3232 1.7972 1.7972 --- 

 adjusted for DDREF 1.1616 1.7972 0.8986 --- 

ERR/Sv 1.1616 1.7972 0.8986 --- 

Organ equivalent dose (Sv) 0.0818935 0.0814716 0.08 ---  Linear Quadratic (1=Yes, 0=No) 0 0 0 --- 

Excess relative risk (ERR) 0.095 0.146 0.072 --- 

Final results calculated in Excel Midpointc

Total Excess relative risk (ERR) 0.313Probability of Causation (PC) 23.86

c Midpoint values are representative of the iteration closest to the 50th percentile

Verification of Midpoint Values using MS Excel

Exposure #
Verification Run Identifier Mult Exp 5

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Liver Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1925 1930 1935 ---  Age at exposure 25 30 35 --- 

 Exposure rate chronic acute chronic --- 

 Radiation type photons E<30keV photons E=30-250keV photons E>250keV --- 

Parameter 1 2 3 4 

Monte Carlo iteration number for 99th percentile 1301 1301 1301 --- Original ERR/Sv, correlated w/ age adjustment 0.8327 0.6601 0.6601 --- 

Adjustment Factors Age at exposure, Attained age 1.0000 1.0000 1.0000 ---  Minimum latency for cancer induction 1.0000 1.0000 1.0000 ---  Random errors in dosesa 0.1199 0.1199 0.1199 --- 

 Systematic errors in gamma dosesa 1.2456 1.2456 1.2456 ---  Systematic errors in neutron dosesa 1.0099 1.0099 1.0099 ---  Systematic errors in RBE neutron dosesa 0.9819 0.9819 0.9819 ---  Model Mixture factor for transfer to US pop 0.0515 0.0515 0.0515 ---  Ratio of Japanese to U.S. baseline cancer rates 7.8980 7.8980 7.8980 ---  Smoking history 1 1 1 --- 

 Dose and dose rate effectiveness factor (DDREF) 0.7 1 0.7 --- 

Organ equivalent dose (cSv)b 5 6 8 --- 

 Radiation weighting factor (wR - ICRP 60) 1 1 1 --- 

 Radiation effectiveness factor (REF) 2.52989 1.7265 1 --- 

Final results calculated by NIOSH-IREP Upperc

Excess relative risk (ERR) 2.013Probability of Causation (PC) 66.81

a Doses to the Japanese atomic bomb survivors b Dose assigned to the claimantc Upper values are representative of the iteration closest to the 99th percentile

Upper Bound Values Reported by NIOSH-IREP v.5.5.3r

Exposure #
Verification Run Identifier Mult Exp 5

Personal Information

 Gender Male Birth year 1900 Diagnosis year 1960 Cancer Liver Attained age 60Exposure Information Exposure 1 Exposure 2 Exposure 3 Exposure 4 

 Exposure year 1925 1930 1935 --- 

 Age at exposure 25 30 35 --- 

 Exposure rate chronic acute chronic --- 

 Radiation type photons E<30keV photons E=30-250keV photons E>250keV --- Intermediate results calculated in Excel 1 2 3 4 ERR/Sv correlated w/ age adjustment 0.8327 0.6601 0.6601 --- 

 w/ latency adjustment 0.8327 0.6601 0.6601 w/ random errors in dosimetry adj 0.9326 0.7393 0.7393 --- 

 w/ systematic errors in dosimetry adj 0.7551 0.5986 0.5986 --- 

 adjusted for population transfer 5.6955 4.5152 4.5152 --- 

 multiplicative risk model 0.7551 0.5986 0.5986 --- 

 additive risk model 5.9636 4.7277 4.7277 --- 

 adjusted for smoking history 5.6955 4.5152 4.5152 --- 

 adjusted for DDREF 8.1365 4.5152 6.4503 --- 

ERR/Sv 8.1365 4.5152 6.4503 --- 

Organ equivalent dose (Sv) 0.1264945 0.10359 0.08 ---  Linear Quadratic (1=Yes, 0=No) 0 0 0 --- 

Excess relative risk (ERR) 1.029 0.468 0.516 --- 

Final results calculated in Excel Upperc

Total Excess relative risk (ERR) 2.013Probability of Causation (PC) 66.81

c Upper values are representative of the iteration closest to the 99th percentile

Verification of Upper Bound Values using MS Excel

Exposure #
Appendix J 

Results of Testing the Monte Carlo Uncertainty Propagation Algorithms 

The calculations presented in this appendix verify that the Monte-Carlo 

uncertainty propagation algorithm used in NIOSH-IREP operates properly. In these 

verification calculations, probability distribution functions for ERR and PC produced by 

NIOSH-IREP are compared to probability distribution functions for ERR and PC 

obtained from the independent programming of the risk models into Microsoft Excel® 

combined with Crystal Ball®. The risk models programmed in MS Excel/Crystal Ball 

contain all parameters defined using the probability distributions listed in the technical 

documentation of NIOSH-IREP. Although the two Monte-Carlo calculations, one in 

NIOSH-IREP and one in MS Excel/Crystal Ball, are not identical, they do not differ by 

more than the margin of error for a Monte-Carlo operation (as discussed in Section 6 of 

this report). 

Verification calculations for this section were performed first using a LHS sample 

size of 2,000 followed by 30 individual runs of 10,000 iterations each. Comparisons 

based on the 30 runs of 10,000 iterations minimize the differences in ERR and PC due to 

differences in the random number generator used by the Analytica® and Crystal Ball® 

software packages. Verification calculations were performed for oral cavity, colon, 

bladder, and nervous system and for two combinations of ages at exposure and ages at 

diagnosis. All scenarios considered for this set of verification calculations represent 

males exposed to an acute dose of 20 cSv of high energy photons (E > 250 keV). 

The results of the Monte-Carlo calculations are presented in this appendix both in 

tabular and graphical form. The tables of results show the 1st, 5th, 50th, 95th and 99th

percentiles of the probability distributions obtained by Monte-Carlo methods in NIOSHIREP and in MS Excel/Crystal Ball for each of the 30 runs of 10,000 iterations and show 

the average of the 30 runs at each of the five percentiles selected for verification testing. 

The graphs included in this appendix are probability plots comparing the entire 

probability distributions for ERR and PC produced by NIOSH-IREP and by MS 

Excel/Crystal Ball using a Monte-Carlo LHS sample size of 2,000. 

 
 

This page was intentionally left blank. 
Table J-1. ERR values for a male exposed to high-energy gamma raysa at age 40; diagnosed with an oral cavity cancer at a

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.00 0.0041 0.028 0.071 0.098 0.00 0.0040 0.028 

2 98396 0.00 0.0042 0.028 0.070 0.097 0.00 0.0042 0.028 

3 878134 0.00 0.0042 0.028 0.071 0.096 0.00 0.0042 0.028 

4 273343 0.00 0.0042 0.028 0.071 0.098 0.00 0.0041 0.028 

5 87715 0.00 0.0042 0.028 0.071 0.097 0.00 0.0042 0.028 

6 910178 0.00 0.0041 0.028 0.071 0.096 0.00 0.0042 0.028 

7 177211 0.00 0.0041 0.028 0.071 0.097 0.00 0.0041 0.028 

8 376111 0.00 0.0041 0.028 0.072 0.097 0.00 0.0041 0.028 

9 44990 0.00 0.0042 0.028 0.072 0.097 0.00 0.0042 0.028 

10 38354 0.00 0.0041 0.028 0.071 0.096 0.00 0.0042 0.028 

11 792683 0.00 0.0041 0.028 0.071 0.097 0.00 0.0042 0.028 12 529695 0.00 0.0041 0.028 0.071 0.097 0.00 0.0041 0.028 13 53080 0.00 0.0041 0.028 0.071 0.098 0.00 0.0041 0.028 

14 482924 0.00 0.0041 0.028 0.070 0.097 0.00 0.0042 0.028 15 724550 0.00 0.0040 0.028 0.070 0.096 0.00 0.0041 0.028 16 999673 0.00 0.0041 0.028 0.071 0.098 0.00 0.0041 0.028 17 643144 0.00 0.0041 0.028 0.071 0.098 0.00 0.0041 0.028 18 978311 0.00 0.0042 0.028 0.071 0.097 0.00 0.0042 0.028 19 707232 0.00 0.0041 0.028 0.072 0.095 0.00 0.0041 0.028 20 786047 0.00 0.0041 0.028 0.071 0.098 0.00 0.0041 0.028 21 284024 0.00 0.0043 0.028 0.071 0.098 0.00 0.0041 0.028 22 55671 0.00 0.0042 0.028 0.071 0.099 0.00 0.0041 0.028 

23 6310 0.00 0.0041 0.028 0.071 0.097 0.00 0.0042 0.028 

24 888815 0.00 0.0043 0.028 0.071 0.098 0.00 0.0042 0.028 25 241299 0.00 0.0040 0.028 0.071 0.096 0.00 0.0042 0.028 26 183847 0.00 0.0041 0.028 0.072 0.097 0.00 0.0041 0.028 27 621782 0.00 0.0041 0.028 0.071 0.096 0.00 0.0041 0.028 28 42399 0.00 0.0041 0.028 0.071 0.100 0.00 0.0041 0.028 

29 514968 0.00 0.0041 0.028 0.071 0.097 0.00 0.0042 0.028 30 628418 0.00 0.0042 0.028 0.072 0.095 0.00 0.0040 0.028 

Average of 30 runsb 0.00 0.0042 0.0281 0.0711 0.0970 0.000 0.0041 0.0281 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

ERR values reported by NIOSH-IREP EE (v.5.5.3r) ERR values reported by 

Percentile Percent
Table J-2. PC results for a male exposed to high-energy gamma raysa at age 40; diagnosed with an oral cavity cancer at ag

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.00 0.41 2.73 6.61 8.90 0.00 0.40 2.74 

2 98396 0.00 0.42 2.73 6.57 8.86 0.00 0.42 2.73 

3 878134 0.00 0.42 2.73 6.61 8.76 0.00 0.42 2.72 

4 273343 0.00 0.42 2.74 6.67 8.90 0.00 0.41 2.73 

5 87715 0.00 0.42 2.73 6.64 8.85 0.00 0.41 2.72 

6 910178 0.00 0.41 2.74 6.65 8.75 0.00 0.42 2.73 

7 177211 0.00 0.41 2.74 6.63 8.84 0.00 0.41 2.73 

8 376111 0.00 0.41 2.73 6.68 8.87 0.00 0.41 2.73 

9 44990 0.00 0.42 2.75 6.70 8.81 0.00 0.42 2.75 

10 38354 0.00 0.41 2.74 6.66 8.77 0.00 0.41 2.73 

11 792683 0.00 0.41 2.73 6.66 8.87 0.00 0.42 2.72 

12 529695 0.00 0.41 2.75 6.66 8.82 0.00 0.41 2.74 

13 53080 0.00 0.41 2.73 6.64 8.90 0.00 0.41 2.74 

14 482924 0.00 0.41 2.75 6.58 8.87 0.00 0.42 2.73 

15 724550 0.00 0.40 2.73 6.58 8.74 0.00 0.41 2.73 

16 999673 0.00 0.41 2.73 6.62 8.93 0.00 0.41 2.74 

17 643144 0.00 0.41 2.75 6.62 8.92 0.00 0.41 2.73 

18 978311 0.00 0.42 2.73 6.62 8.86 0.00 0.42 2.75 

19 707232 0.00 0.41 2.73 6.68 8.67 0.00 0.41 2.72 

20 786047 0.00 0.41 2.74 6.66 8.90 0.00 0.41 2.73 

21 284024 0.00 0.43 2.73 6.66 8.92 0.00 0.41 2.74 

22 55671 0.00 0.42 2.72 6.62 8.99 0.00 0.41 2.74 

23 6310 0.00 0.41 2.74 6.59 8.86 0.00 0.42 2.74 

24 888815 0.00 0.43 2.73 6.64 8.89 0.00 0.42 2.73 

25 241299 0.00 0.40 2.73 6.64 8.72 0.00 0.42 2.73 

26 183847 0.00 0.41 2.73 6.74 8.82 0.00 0.41 2.74 

27 621782 0.00 0.41 2.74 6.63 8.74 0.00 0.41 2.75 

28 42399 0.00 0.41 2.73 6.60 9.05 0.00 0.41 2.72 

29 514968 0.00 0.41 2.74 6.67 8.82 0.00 0.42 2.73 

30 628418 0.00 0.42 2.72 6.68 8.68 0.00 0.40 2.73 

Average of 30 runsb 0.00 0.413 2.73 6.64 8.84 0.000 0.413 2.73 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

PC values (%) reported by NIOSH-IREP EE (v.5.5.3r) PC values (%) reported b

Percentile Percent
0

2

4

6

8

10

12

14

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

PC (%)

Percent

ORAL CAVITY AND PHARYNX

 = 8.75%

 = 8.84%

99th percentile of PC

Crystal Ball

NIOSH-IREP v.5.5.3r 

0.00

0.02

0.04

0.06

0.08

0.10

0.12

0.14

0.16

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

ERR

Percent

ORAL CAVITY AND PHARYNX

Fig. J-1 Comparison of the probability distribution functions for ERR and PC 

based on a single run of 2,000 iterations with NIOSH-IREP and MS 

Excel/Crystal Ball. The scenario represents a male with an oral cavity and 

pharynx cancer diagnosed at age 60, and who was exposed at age 40 to 

an acute dose of 20 cSv of high energy photons (E > 250 keV). 
Table J-3. ERR values for a male exposed to high-energy gamma raysa at age 20; diagnosed with a colon cancer at age 60.

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.02 0.05 0.16 0.34 0.45 0.015 0.047 0.158 

2 98396 0.01 0.05 0.16 0.34 0.44 0.015 0.048 0.158 

3 878134 0.01 0.05 0.16 0.34 0.45 0.014 0.048 0.158 

4 273343 0.02 0.05 0.16 0.34 0.45 0.015 0.048 0.158 

5 87715 0.01 0.05 0.16 0.34 0.46 0.015 0.047 0.158 

6 910178 0.01 0.05 0.16 0.34 0.45 0.015 0.048 0.159 

7 177211 0.02 0.05 0.16 0.34 0.44 0.015 0.048 0.157 

8 376111 0.01 0.05 0.16 0.34 0.46 0.015 0.047 0.159 

9 44990 0.01 0.05 0.16 0.34 0.45 0.015 0.048 0.159 

10 38354 0.01 0.05 0.16 0.34 0.45 0.015 0.048 0.158 

11 792683 0.02 0.05 0.16 0.34 0.44 0.015 0.047 0.159 

12 529695 0.02 0.05 0.16 0.34 0.45 0.015 0.048 0.158 

13 53080 0.01 0.05 0.16 0.34 0.45 0.015 0.048 0.158 

14 482924 0.01 0.05 0.16 0.34 0.44 0.014 0.047 0.159 

15 724550 0.02 0.05 0.16 0.34 0.45 0.016 0.047 0.158 

16 999673 0.01 0.05 0.16 0.34 0.44 0.016 0.048 0.158 

17 643144 0.01 0.05 0.16 0.34 0.44 0.015 0.048 0.158 

18 978311 0.02 0.05 0.16 0.34 0.44 0.016 0.048 0.158 

19 707232 0.02 0.05 0.16 0.34 0.46 0.016 0.047 0.158 

20 786047 0.02 0.05 0.16 0.34 0.44 0.016 0.047 0.159 

21 284024 0.02 0.05 0.16 0.34 0.45 0.015 0.047 0.159 

22 55671 0.01 0.05 0.16 0.34 0.44 0.015 0.047 0.157 

23 6310 0.02 0.05 0.16 0.34 0.45 0.015 0.048 0.159 

24 888815 0.02 0.05 0.16 0.34 0.45 0.015 0.048 0.159 

25 241299 0.02 0.05 0.16 0.34 0.44 0.015 0.048 0.158 

26 183847 0.01 0.05 0.16 0.34 0.44 0.016 0.048 0.158 

27 621782 0.01 0.05 0.16 0.34 0.45 0.013 0.048 0.159 

28 42399 0.02 0.05 0.16 0.34 0.45 0.015 0.048 0.159 

29 514968 0.02 0.05 0.16 0.34 0.45 0.015 0.047 0.159 

30 628418 0.02 0.05 0.16 0.34 0.45 0.015 0.047 0.158 

Average of 30 runsb 0.01 0.0476 0.158 0.341 0.447 0.015 0.048 0.158 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

ERR values reported by NIOSH-IREP EE (v.5.5.3r) ERR values reported by 

Percentile Percent
Table J-4. PC results for a male exposed to high-energy gamma raysa at age 20; diagnosed with a colon cancer at age 60.

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 1.50 4.54 13.65 25.55 30.95 1.45 4.52 13.64 

2 98396 1.45 4.58 13.68 25.31 30.56 1.44 4.56 13.67 

3 878134 1.44 4.52 13.64 25.41 31.11 1.42 4.61 13.68 

4 273343 1.52 4.56 13.66 25.43 31.01 1.45 4.59 13.67 

5 87715 1.47 4.58 13.61 25.54 31.35 1.45 4.45 13.66 

6 910178 1.46 4.53 13.72 25.59 31.08 1.46 4.61 13.70 

7 177211 1.49 4.50 13.65 25.28 30.46 1.52 4.54 13.56 

8 376111 1.46 4.51 13.67 25.34 31.29 1.51 4.52 13.69 

9 44990 1.44 4.54 13.67 25.55 30.92 1.52 4.54 13.70 

10 38354 1.37 4.58 13.58 25.37 31.00 1.50 4.57 13.65 

11 792683 1.51 4.50 13.68 25.25 30.78 1.50 4.53 13.69 

12 529695 1.48 4.59 13.66 25.32 31.09 1.47 4.56 13.65 

13 53080 1.46 4.52 13.64 25.47 30.92 1.49 4.54 13.67 

14 482924 1.47 4.52 13.70 25.46 30.76 1.38 4.50 13.69 

15 724550 1.53 4.51 13.62 25.28 30.84 1.55 4.53 13.63 

16 999673 1.42 4.49 13.69 25.47 30.72 1.54 4.56 13.62 

17 643144 1.44 4.55 13.63 25.60 30.53 1.48 4.55 13.65 

18 978311 1.48 4.57 13.59 25.46 30.61 1.53 4.55 13.65 

19 707232 1.53 4.58 13.71 25.42 31.32 1.53 4.49 13.68 

20 786047 1.51 4.49 13.70 25.58 30.67 1.55 4.47 13.71 

21 284024 1.49 4.57 13.59 25.55 31.01 1.51 4.53 13.69 

22 55671 1.37 4.57 13.62 25.42 30.70 1.49 4.49 13.60 

23 6310 1.49 4.53 13.63 25.65 31.05 1.46 4.55 13.69 

24 888815 1.50 4.52 13.65 25.48 31.22 1.46 4.56 13.69 

25 241299 1.49 4.47 13.70 25.40 30.56 1.50 4.56 13.65 

26 183847 1.44 4.58 13.63 25.38 30.68 1.53 4.54 13.64 

27 621782 1.41 4.61 13.63 25.40 30.90 1.31 4.54 13.72 

28 42399 1.51 4.54 13.66 25.44 31.05 1.50 4.58 13.71 

29 514968 1.53 4.56 13.68 25.31 31.05 1.48 4.49 13.68 

30 628418 1.51 4.57 13.60 25.37 31.04 1.44 4.53 13.63 

Average of 30 runs 1.47 4.54 13.65 25.44 30.91 1.48 4.54 13.67 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

PC values (%) reported by NIOSH-IREP EE (v.5.5.3r) PC values (%) reported b

Percentile Percent
0

10

20

30

40

50

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

PC (%)

Percent

COLON

 = 30.31%

 = 30.95%

99th percentile of PC

Crystal Ball

NIOSH-IREP v.5.5.3r

0.00

0.10

0.20

0.30

0.40

0.50

0.60

0.70

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

ERR

Percent

COLON

Fig. J-2 Comparison of the probability distribution functions for ERR and PC 

based on a single run of 2,000 iterations with NIOSH-IREP and 

MS Excel/Crystal Ball. The scenario represents a male with a colon 

cancer diagnosed at age 60, and who was exposed at age 20 to an acute 

dose of 20 cSv of high energy photons (E > 250 keV). 
Table J-5. ERR values for a male exposed to high-energy gamma raysa at age 40; diagnosed with a bladder cancer at age 6

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.068 

2 98396 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

3 878134 0.01 0.02 0.07 0.15 0.19 0.009 0.023 0.069 

4 273343 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

5 87715 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

6 910178 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

7 177211 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

8 376111 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

9 44990 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

10 38354 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

11 792683 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

12 529695 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

13 53080 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

14 482924 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.068 

15 724550 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

16 999673 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

17 643144 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

18 978311 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

19 707232 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

20 786047 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

21 284024 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.070 

22 55671 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

23 6310 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

24 888815 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

25 241299 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

26 183847 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

27 621782 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

28 42399 0.01 0.02 0.07 0.15 0.20 0.010 0.023 0.069 

29 514968 0.01 0.02 0.07 0.15 0.20 0.010 0.024 0.069 

30 628418 0.01 0.02 0.07 0.15 0.19 0.010 0.023 0.069 

Average of 30 runsb 0.01 0.0230 0.069 0.148 0.194 0.010 0.023 0.069 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

ERR values reported by NIOSH-IREP EE (v.5.5.3r) ERR values reported by 

Percentile Percent
Table J-6. PC results for a male exposed to high-energy gamma raysa at age 40; diagnosed with a bladder cancer at age 60

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.98 2.25 6.45 12.86 16.30 0.98 2.25 6.40 

2 98396 0.94 2.25 6.45 12.79 16.27 0.95 2.23 6.44 

3 878134 0.94 2.30 6.44 12.82 16.13 0.93 2.23 6.47 

4 273343 0.97 2.30 6.47 12.95 16.28 0.95 2.23 6.46 

5 87715 0.97 2.24 6.46 12.99 16.28 0.98 2.24 6.45 

6 910178 0.99 2.24 6.42 12.98 16.09 1.01 2.25 6.44 

7 177211 0.96 2.23 6.45 12.95 16.20 0.97 2.21 6.45 

8 376111 0.99 2.23 6.43 12.94 16.34 1.02 2.27 6.45 

9 44990 0.92 2.26 6.46 12.87 16.41 0.99 2.22 6.44 

10 38354 0.97 2.23 6.46 12.96 16.17 0.98 2.25 6.44 

11 792683 0.95 2.25 6.44 12.93 16.43 0.95 2.24 6.46 

12 529695 0.96 2.26 6.50 12.98 16.21 1.01 2.24 6.44 

13 53080 1.01 2.22 6.42 12.87 16.35 0.96 2.22 6.45 

14 482924 0.99 2.24 6.46 12.81 16.34 0.95 2.27 6.41 

15 724550 0.94 2.22 6.46 12.85 16.07 0.97 2.24 6.50 

16 999673 0.97 2.24 6.44 12.87 16.53 0.98 2.24 6.45 

17 643144 1.01 2.25 6.48 12.88 16.41 0.97 2.23 6.48 

18 978311 1.01 2.26 6.48 12.82 16.29 0.96 2.26 6.45 

19 707232 1.04 2.24 6.46 12.90 16.09 0.96 2.27 6.46 

20 786047 0.97 2.26 6.47 12.87 16.10 0.96 2.29 6.44 

21 284024 1.02 2.27 6.44 12.94 16.34 1.01 2.23 6.51 

22 55671 0.97 2.23 6.43 12.84 16.53 1.03 2.23 6.45 

23 6310 1.01 2.23 6.47 12.85 16.30 0.99 2.27 6.46 

24 888815 0.95 2.27 6.43 12.97 16.40 0.99 2.21 6.47 

25 241299 0.96 2.22 6.45 12.89 16.28 0.99 2.23 6.46 

26 183847 0.97 2.21 6.46 13.09 16.17 0.97 2.22 6.46 

27 621782 1.01 2.23 6.43 12.86 16.06 0.99 2.24 6.47 

28 42399 0.99 2.25 6.46 12.90 16.52 0.99 2.24 6.45 

29 514968 0.99 2.23 6.46 12.91 16.39 0.98 2.30 6.44 

30 628418 0.99 2.27 6.46 12.93 15.88 0.99 2.24 6.44 

Average of 30 runs 0.98 2.25 6.45 12.90 16.27 0.98 2.24 6.45 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

PC values (%) reported by NIOSH-IREP EE (v.5.5.3r) PC values (%) reported b

Percentile Percent
0

5

10

15

20

25

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

PC (%)

Percent

BLADDER

 = 16.62%

 = 16.77%

99th percentile of PC

Crystal Ball

NIOSH-IREP v.5.5.3r

0.00

0.05

0.10

0.15

0.20

0.25

0.30

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

ERR

Percent

BLADDER

Fig. J-3 Comparison of the probability distribution functions for ERR and PC 

based on a single run of 2,000 iterations with NIOSH-IREP and 

MS Excel/Crystal Ball. The scenario represents a male with a bladder 

cancer diagnosed at age 60, and who was exposed at age 40 to an acute 

dose of 20 cSv of high energy photons (E > 250 keV). 
Table J-7. ERR values for a male exposed to high-energy gamma raysa at age 20; diagnosed with a cancer of the nervous s

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.00 0.003 0.038 0.123 0.184 0.000 0.003 0.037 

2 98396 0.00 0.003 0.038 0.122 0.185 0.000 0.003 0.037 

3 878134 0.00 0.003 0.037 0.123 0.183 0.000 0.003 0.038 

4 273343 0.00 0.003 0.037 0.122 0.183 0.000 0.003 0.037 

5 87715 0.00 0.003 0.037 0.123 0.188 0.000 0.003 0.037 

6 910178 0.00 0.003 0.037 0.123 0.188 0.000 0.003 0.037 

7 177211 0.00 0.003 0.037 0.122 0.184 0.000 0.003 0.037 

8 376111 0.00 0.003 0.037 0.124 0.186 0.000 0.003 0.037 

9 44990 0.00 0.003 0.038 0.125 0.188 0.000 0.003 0.037 

10 38354 0.00 0.003 0.037 0.122 0.187 0.000 0.003 0.037 

11 792683 0.00 0.003 0.037 0.123 0.182 0.000 0.003 0.037 

12 529695 0.00 0.003 0.038 0.123 0.185 0.000 0.003 0.037 

13 53080 0.00 0.003 0.037 0.120 0.186 0.000 0.003 0.037 

14 482924 0.00 0.003 0.037 0.122 0.181 0.000 0.003 0.037 

15 724550 0.00 0.003 0.038 0.123 0.180 0.000 0.003 0.038 

16 999673 0.00 0.003 0.038 0.122 0.184 0.000 0.003 0.037 

17 643144 0.00 0.003 0.038 0.123 0.182 0.000 0.003 0.038 

18 978311 0.00 0.003 0.037 0.123 0.183 0.000 0.003 0.037 

19 707232 0.00 0.003 0.037 0.122 0.186 0.000 0.003 0.037 

20 786047 0.00 0.003 0.037 0.121 0.185 0.000 0.003 0.038 

21 284024 0.00 0.003 0.037 0.124 0.183 0.000 0.003 0.038 

22 55671 0.00 0.003 0.037 0.122 0.183 0.000 0.003 0.037 

23 6310 0.00 0.003 0.037 0.124 0.186 0.000 0.003 0.037 

24 888815 0.00 0.004 0.037 0.124 0.184 0.000 0.003 0.038 

25 241299 0.00 0.003 0.038 0.121 0.178 0.000 0.003 0.038 

26 183847 0.00 0.003 0.037 0.124 0.184 0.000 0.003 0.038 

27 621782 0.00 0.003 0.037 0.121 0.183 0.000 0.003 0.037 

28 42399 0.00 0.003 0.038 0.123 0.189 0.000 0.003 0.037 

29 514968 0.00 0.003 0.037 0.123 0.187 0.000 0.003 0.037 

30 628418 0.00 0.003 0.037 0.121 0.183 0.000 0.003 0.037 

Average of 30 runsb 0.00 0.0033 0.037 0.123 0.184 0.000 0.003 0.037 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

ERR values reported by NIOSH-IREP EE (v.5.5.3r) ERR values reported by 

Percentile Percent
Table J-8. PC results for a male exposed to high-energy gamma raysa at age 20; diagnosed with a cancer of the nervous sy

Random seed

Run value 1st 5th 50th 95th 99th 1st 5th 50th 

1 181256 0.00 0.33 3.63 10.94 15.56 0.00 0.33 3.59 

2 98396 0.00 0.33 3.62 10.89 15.62 0.00 0.34 3.60 

3 878134 0.00 0.34 3.58 10.96 15.45 0.00 0.33 3.63 

4 273343 0.00 0.34 3.59 10.91 15.45 0.00 0.32 3.60 

5 87715 0.00 0.33 3.58 10.99 15.80 0.00 0.33 3.60 

6 910178 0.00 0.33 3.60 10.92 15.81 0.00 0.33 3.58 

7 177211 0.00 0.33 3.59 10.91 15.52 0.00 0.32 3.60 

8 376111 0.00 0.32 3.58 11.03 15.66 0.00 0.33 3.59 

9 44990 0.00 0.32 3.63 11.09 15.85 0.00 0.34 3.61 

10 38354 0.00 0.32 3.61 10.90 15.77 0.00 0.34 3.59 

11 792683 0.00 0.33 3.59 10.92 15.37 0.00 0.33 3.61 

12 529695 0.00 0.34 3.62 10.97 15.60 0.00 0.33 3.59 

13 53080 0.00 0.32 3.61 10.75 15.67 0.00 0.32 3.60 

14 482924 0.00 0.32 3.61 10.84 15.34 0.00 0.33 3.59 

15 724550 0.00 0.33 3.65 10.96 15.24 0.00 0.35 3.65 

16 999673 0.00 0.32 3.64 10.90 15.54 0.00 0.32 3.60 

17 643144 0.00 0.33 3.62 10.93 15.41 0.00 0.33 3.62 

18 978311 0.00 0.33 3.61 10.94 15.47 0.00 0.33 3.58 

19 707232 0.00 0.33 3.57 10.85 15.71 0.00 0.34 3.61 

20 786047 0.00 0.33 3.61 10.77 15.58 0.00 0.32 3.63 

21 284024 0.00 0.33 3.58 11.04 15.50 0.00 0.32 3.64 

22 55671 0.00 0.33 3.61 10.91 15.47 0.00 0.33 3.61 

23 6310 0.00 0.32 3.59 11.03 15.69 0.00 0.33 3.61 

24 888815 0.00 0.35 3.60 11.06 15.56 0.00 0.31 3.62 

25 241299 0.00 0.32 3.62 10.81 15.14 0.00 0.32 3.62 

26 183847 0.00 0.34 3.61 11.05 15.54 0.00 0.31 3.62 

27 621782 0.00 0.33 3.58 10.78 15.48 0.00 0.33 3.61 

28 42399 0.00 0.33 3.62 10.97 15.91 0.00 0.33 3.61 

29 514968 0.00 0.33 3.61 10.97 15.73 0.00 0.34 3.59 

30 628418 0.00 0.33 3.59 10.81 15.44 0.00 0.33 3.60 

Average of 30 runs 0.00 0.33 3.61 10.93 15.56 0.00 0.33 3.61 

a Organ dose = 20 cSv (constant)b Each run consists of 10,000 Monte Carlo Iterations

PC values (%) reported by NIOSH-IREP EE (v.5.5.3r) PC values (%) reported b

Percentile Percent
0

5

10

15

20

25

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

PC (%)

Percent

NERVOUS SYSTEM

 = 15.72%

 = 15.62%

99th percentile of PC

Crystal Ball

NIOSH-IREP v.5.5.3r

0.00

0.05

0.10

0.15

0.20

0.25

0.30

0.35

0.40

.1 1 5 10 20 30 50 70 80 90 95 99 99.9

Crystal Ball

NIOSH-IREP v.5.5.3r

ERR

Percent

NERVOUS SYSTEM

Fig. J-4 Comparison of the probability distribution functions for ERR and PC 

based on a single run of 2,000 iterations with NIOSH-IREP and 

MS Excel/Crystal Ball. The scenario represents a male with a nervous 

system cancer diagnosed at age 60, and who was exposed at age 20 to 

an acute dose of 20 cSv of high energy photons (E > 250 keV).