Exhibit 4.1

REGISTRATION RIGHTS AGREEMENT 

dated as of 

September 17, 2014 

among 
 AFFIMED N.V. 

and 
 THE SHAREHOLDERS PARTY
HERETO 







 TABLE OF CONTENTS 

 

							
	 	  	 	  	PAGE	 
	ARTICLE 1	  			
	DEFINITIONS	  			
			
	Section 1.01 .	  	Definitions.	  	 	1	  
	Section 1.02 .	  	Other Definitional and Interpretative Provisions.	  	 	4	  
		
	ARTICLE 2	  			
	REGISTRATION RIGHTS	  			
			
	Section 2.01 .	  	Demand Registration.	  	 	5	  
	Section 2.02 .	  	Piggyback Registration.	  	 	7	  
	Section 2.03 .	  	Shelf Registration.	  	 	8	  
	Section 2.04 .	  	Lock-Up Agreements.	  	 	9	  
	Section 2.05 .	  	Registration Procedures.	  	 	10	  
	Section 2.06 .	  	Participation In Public Offering.	  	 	13	  
	Section 2.07 .	  	Rule 144 Sales; Cooperation By The Company.	  	 	13	  
		
	ARTICLE 3	  			
	INDEMNIFICATION AND CONTRIBUTION	  			
			
	Section 3.01 .	  	Indemnification by the Company.	  	 	14	  
	Section 3.02 .	  	Indemnification by Participating Shareholders.	  	 	14	  
	Section 3.03 .	  	Undertaking.	  	 	15	  
	Section 3.04 .	  	Liability.	  	 	15	  
	Section 3.05 .	  	Conduct of Indemnification Proceedings.	  	 	15	  
	Section 3.06 .	  	Contribution.	  	 	16	  
		
	ARTICLE 4	  			
	MISCELLANEOUS	  			
			
	Section 4.01 .	  	Binding Effect; Assignability; Benefit.	  	 	17	  
	Section 4.02 .	  	Notices.	  	 	17	  
	Section 4.03 .	  	Waiver; Amendment; Termination.	  	 	18	  
	Section 4.04 .	  	Governing Law.	  	 	19	  
	Section 4.05 .	  	Jurisdiction.	  	 	19	  
	Section 4.06 .	  	WAIVER OF JURY TRIAL.	  	 	19	  
	Section 4.07 .	  	Specific Enforcement.	  	 	19	  
	Section 4.08 .	  	Counterparts; Effectiveness.	  	 	19	  
	Section 4.09 .	  	Entire Agreement.	  	 	20	  
	Section 4.10 .	  	Severability.	  	 	20	  
	Section 4.11 .	  	Confidentiality.	  	 	20	  
	 Section 4.12 .
	  	Independent Nature of Shareholders’ Obligations and Rights.	  	 	20	  


  
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	Exhibit A	  	Joinder Agreement


  
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 REGISTRATION RIGHTS AGREEMENT 

THIS REGISTRATION RIGHTS AGREEMENT dated as of September 17, 2014 (this
“Agreement”) by and among Affimed N.V., a Dutch public company with limited liability (the “Company”), and the shareholders listed on the signature pages hereto, as well as any Permitted Transferees (as defined
below). 
 In consideration of the mutual promises made herein and other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows: 
 ARTICLE 1 

DEFINITIONS 

Section 1.01. Definitions. (a) The following terms, as used herein, have the following meanings: 

“Affiliate” means, with respect to any Person, any other Person directly or indirectly controlling, controlled by or under
common control with such Person, provided that no securityholder of the Company shall be deemed an Affiliate of any other securityholder solely by reason of any investment in the Company. For the purpose of this definition, the term
“control” (including, with correlative meanings, the terms “controlling”, “controlled by” and “under common control with”), as used with respect to any Person, means the possession,
directly or indirectly, of the power to direct or cause the direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or otherwise. 

“Business Day” means any day except a Saturday, Sunday or other day on which commercial banks in New York City are authorized
by law to close. 
 “Common Shares” means common shares, nominal value €0.01 per share, of the Company and any
shares into which such Common Shares may thereafter be converted or changed. 
 “Exchange Act” means the Securities
Exchange Act of 1934, as amended. 
 “FINRA” means the Financial Industry Regulatory Authority (formerly, the National
Association of Securities Dealers, Inc.) and any successor thereto. 
 “First Public Offering” means the Company’s
initial Public Offering. 
 “Permitted Transferee” means in the case of any Shareholder, a Person to whom Registrable
Securities are Transferred by such Shareholder in accordance with Section 4.01(b); provided that (i) such Transfer does not violate any agreements between such Shareholder and the Company or any of the Company’s subsidiaries,
(ii) such Transfer is not made in a registered offering or 

  
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pursuant to Rule 144 and (iii) such transferee shall only be a Permitted Transferee if and to the extent the transferor designates the transferee as a Permitted Transferee entitled to rights
hereunder pursuant to Section 4.01(b). 
 “Person” means an individual, corporation, limited liability company,
partnership, association, trust or other entity or organization, including a government or political subdivision or an agency or instrumentality thereof. 

“Public Offering” means an underwritten public offering of Registrable Securities of the Company pursuant to an
effective registration statement under the Securities Act, other than pursuant to a registration statement on Form S-4, Form F-4 or Form S-8 or any similar or successor form. 

“Registrable Securities” means, at any time, any Common Shares and any other securities issued or issuable by the Company or
any of its successors or assigns in respect of any such Common Shares by way of conversion, exchange, exercise, dividend, split, reverse split, combination, recapitalization, reclassification, merger, amalgamation, consolidation, sale of assets,
other reorganization or otherwise until (i) a registration statement covering such Common Shares or such other securities has been declared effective by the SEC and such Common Shares or such other securities have been disposed of pursuant to
such effective registration statement, (ii) such Common Shares or such other securities are sold under circumstances in which all of the applicable conditions of Rule 144 are met or (iii) such Common Shares or such other securities are
eligible for sale by the holder thereof under Rule 144 without any limitation thereunder (including with respect to volume or manner of sale) or need for current public information. 

“Registration Expenses” means any and all expenses incident to the performance of, or compliance with, any
registration or marketing of securities, including all (i) registration and filing fees, and all other fees and expenses payable in connection with the listing of securities on any securities exchange or automated interdealer quotation system,
(ii) fees and expenses of compliance with any securities or “blue sky” laws (including reasonable and documented fees and disbursements of counsel in connection with “blue sky” qualifications of the securities registered),
(iii) expenses in connection with the preparation, printing, mailing and delivery of any registration statements, prospectuses and other documents in connection therewith and any amendments or supplements thereto, (iv) security engraving
and printing expenses, (v) internal expenses of the Company (including all salaries and expenses of its officers and employees performing legal or accounting duties), (vi) reasonable fees and disbursements of counsel for the Company and
customary fees and expenses for independent certified public accountants retained by the Company (including the expenses relating to any comfort letters or costs associated with the delivery by independent certified public accountants of any comfort
letters requested pursuant to Section 2.05(h)), (vii) reasonable fees and expenses of any special experts retained by the Company in connection with such registration, (viii) reasonable and documented 


  
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fees, out-of-pocket costs and expenses of the Shareholders, including the reasonable fees and disbursements of one counsel for all of the Shareholders participating in the offering selected by
the Shareholders holding the majority of the Registrable Securities to be sold for the account of all Shareholders in the offering, (ix) fees and expenses in connection with any review by FINRA of the underwriting arrangements or other terms of
the offering, and all fees and expenses of any “qualified independent underwriter,” including the reasonable and documented fees and expenses of any counsel thereto, (x) fees and disbursements of underwriters customarily paid by
issuers or sellers of securities, but excluding any underwriting fees, discounts and commissions attributable to the sale of Registrable Securities, (xi) costs of printing and producing any agreements among underwriters, underwriting
agreements, any “blue sky” or legal investment memoranda and any selling agreements and other documents in connection with the offering, sale or delivery of the Registrable Securities, (xii) transfer agents’ and registrars’
fees and expenses and the fees and expenses of any other agent or trustee appointed in connection with such offering and (xiii) expenses relating to any analyst or investor presentations or any “road shows” undertaken in connection
with the registration, marketing or selling of the Registrable Securities. Except as set forth in clause (viii) above, Registration Expenses shall not include any out-of-pocket expenses of the Shareholders (or the agents who manage their
accounts). For the avoidance of doubt, Registration Expenses shall not include any underwriting fees, discounts, commissions or taxes attributable to the sale of Registrable Securities. 

“Rule 144” means Rule 144 (or any successor or similar provisions) under the Securities Act. 

“SEC” means the Securities and Exchange Commission. 

“Securities Act” means the Securities Act of 1933, as amended. 

“Shareholder” means at any time, any Person (other than the Company) who shall then be a party to or bound by this Agreement,
so long as such Person shall “beneficially own” (as such term is defined in Rule 13d-3 of the Exchange Act) any Registrable Securities. 

“Transfer” means, with respect to any Registrable Securities, (i) when used as a verb, to sell, assign, dispose of,
exchange, pledge, encumber, hypothecate or otherwise transfer such Registrable Securities or any participation or interest therein, whether directly or indirectly, or agree or commit to do any of the foregoing and (ii) when used as a noun, a
direct or indirect sale, assignment, disposition, exchange, pledge, encumbrance, hypothecation, or other transfer of such Registrable Securities or any participation or interest therein or any agreement or commitment to do any of the foregoing. 

“Warrant Shares” means the Common Shares to be received upon exercise of that certain Warrant for the Subscription of Common Shares between the Company and PCOF 1 LLC dated on or about the date hereof. 


  
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 (b) Each of the following terms is defined in the Section set forth opposite such term: 

 

			
	 Term
	  	Section
	 Agreement
	  	Preamble
	 Company
	  	Preamble
	 Damages
	  	3.01
	 Demand Notice
	  	2.01(a)
	 Demand Registration
	  	2.01(a)
	 Indemnified Party
	  	3.05
	 Indemnifying Party
	  	3.05
	 Initial Requesting Shareholders
	  	2.01(a)
	 Initial Shelf Requesting Shareholders
	  	2.03
	 Inspectors
	  	2.05(g)
	 Joinder Agreement
	  	4.01(b)
	 Lock-Up Period
	  	2.04
	 Maximum Offering Size
	  	2.01(e)
	 Notice
	  	4.02
	 Piggyback Registration
	  	2.02(a)
	 Records
	  	2.05(g)
	 Requesting Shareholder
	  	2.01(a)
	 Shelf Registration
	  	2.03
	 Shelf Requesting Shareholder
	  	2.03
	 Underwritten Takedown
	  	2.03

 Section 1.02. Other Definitional and Interpretative Provisions. The words
“hereof”, “herein” and “hereunder” and words of like import used in this Agreement shall refer to this Agreement as a whole and not to any particular provision of this Agreement. The captions herein are included for
convenience of reference only and shall be ignored in the construction or interpretation hereof. References to Articles, Sections or Exhibits are to Articles, Sections and Exhibits of this Agreement unless otherwise specified. All Exhibits annexed
hereto or referred to herein are hereby incorporated in and made a part of this Agreement as if set forth in full herein. Any capitalized term used in any Exhibit but not otherwise defined therein shall have the meaning as defined in this Agreement.
Any singular term in this Agreement shall be deemed to include the plural, and any plural term the singular. Whenever the words “include”, “includes” or “including” are used in this Agreement, they shall be deemed to be
followed by the words “without limitation”, whether or not they are in fact followed by those words or words of like import. “Writing”, “written” and comparable terms refer to printing, typing and other means of
reproducing words (including electronic media) in a visible form. References to any agreement or contract are to that agreement or contract as amended, modified or supplemented from time to time in accordance with the terms hereof and thereof.
References to any Person include the successors and permitted assigns of that Person. References from or through any date mean, unless otherwise specified, from and including or through and including, respectively. 

  
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 ARTICLE 2 

REGISTRATION RIGHTS 

Section 2.01. Demand Registration. (a) If at any time after 180 days following the completion of the
First Public Offering, the Company shall receive a request from a Shareholder or group of Shareholders, in each case holding at least 40% of the Registrable Securities (the requesting Shareholder(s) shall be referred to herein as the
“Initial Requesting Shareholders”), that the Company effect the registration under the Securities Act of all or any portion of such Initial Requesting Shareholder’s Registrable Securities, and specifying the intended method of
disposition thereof, then the Company shall give notice (a “Demand Notice”) of such requested registration (each such request shall be referred to herein as a “Demand Registration”) to the other Shareholders, which
notice shall be given not later than five Business Days prior to the anticipated filing date of the registration statement relating to such Demand Registration. Such other Shareholders may, upon notice received by the Company no later than two
Business Days after the date of notice of a Demand Registration, request that the Company also effect the registration under the Securities Act of all or any portion of such other Shareholder’s Registrable Securities (such other requesting
Shareholders, together with the Initial Requesting Shareholder(s), shall be referred to herein as the “Requesting Shareholders”). Thereafter, subject to the restrictions in Section 2.01(e), the Company shall use commercially
reasonable efforts to effect the registration under the Securities Act of all Registrable Securities for which the Requesting Shareholders have requested registration under this Section 2.01 to the extent necessary to permit the disposition of the
Registrable Securities so to be registered (in accordance with the intended methods thereof as aforesaid), provided that the Company shall be permitted to effect the registration under the Securities Act of any securities other
than the Registrable Securities (including for the benefit of Persons not party to this Agreement) as part of any Demand Registration; provided further that the Company shall not be obligated to effect a Demand Registration
unless the aggregate gross proceeds expected to be received from the sale of the Registrable Securities requested to be included in such Demand Registration equals or exceeds $20,000,000 or such lesser amount that constitutes all of the Requesting
Shareholder’s Registrable Securities (provided that such lesser amount is at least $10,000,000). In no event shall the Company be required to effect (i) more than one Demand Registration hereunder within any six-month period or
(ii) any Demand Registration if, at the time of such request, four or more Demand Registrations and Underwritten Takedowns (as defined below) have previously been effected ((i) and (ii) hereinafter collectively referred to as the
“Demand Registration Limitations”). 
 (b) At any time prior to the effective date of the registration statement
relating to a Demand Registration, a Shareholder may withdraw from the related registration by providing written notice to the Company. If sufficient Registrable Securities are so withdrawn such that the number of Registrable Securities to be
included in such Demand Registration does not meet the applicable threshold 

  
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required for such Demand Registration pursuant to Section 2.01(a), the Company may cease all efforts to effect such Demand Registration, and upon the Company ceasing all efforts to effect
registration, such Demand Registration shall be deemed revoked. A request, so revoked, shall be considered to be a Demand Registration for purposes of the Demand Registration Limitations unless (i) such revocation arose out of the fault of the
Company or (ii) the Requesting Shareholders reimburse the Company for all Registration Expenses (other than the expenses set forth under clause (v) of the definition of the term Registration Expenses) incurred prior to such revocation, pro
rata among such Requesting Shareholders on the basis of the number of Registrable Securities of such Requesting Shareholders that were to be included in such revoked Demand Registration. 

(c) The Company shall be liable for and shall pay all Registration Expenses in connection with any Demand Registration, regardless of whether
such registration is effected, unless the Requesting Shareholders elect to pay such Registration Expenses as described in the last sentence of Section 2.01(b). 

(d) A Demand Registration shall not be deemed to have occurred (other than as provided in Section 2.01(b)) unless the registration statement
relating thereto (i) has become effective under the Securities Act and (ii) has remained effective for a period of at least 30 days (or such shorter period in which all Registrable Securities of the Requesting Shareholders included in such
registration have actually been sold thereunder). 
 (e) If a Demand Registration involves a Public Offering and the managing underwriter
advises the Company and the Requesting Shareholder that, in its view, the number of shares of Registrable Securities requested to be included in such registration (including any securities that the Company proposes to be included that are not
Registrable Securities) exceeds the largest number of shares that can be sold without having an adverse effect on such offering, including the price at which such shares can be sold (the “Maximum Offering Size”), the Company
shall include in such registration, in the priority listed below, up to the Maximum Offering Size: 
 (i) first, all
Registrable Securities requested to be included in such registration by all Requesting Shareholders (allocated, if necessary for the offering not to exceed the Maximum Offering Size, pro rata among such Shareholders on the basis of the relative
number of Registrable Securities so requested to be included in such registration by each such Shareholder; provided, that Warrant Shares shall be treated as "Registrable Securities" and holders of Warrant Shares shall be treated as "Shareholders" for the purpose of this Section 2.01(e)(i) only); and 
 (ii)
second, any securities proposed to be registered by the Company (including for the benefit of any other Persons not party to this Agreement). 

  
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 (f) Upon notice to the Requesting Shareholders, the Company may postpone effecting a Demand
Registration on two occasions during any period of twelve consecutive months for a reasonable time specified in the notice but not exceeding 90 days in the aggregate in any period of twelve consecutive months, if (i) the Board of Directors of
the Company reasonably determines in good faith that effecting the registration would materially and adversely affect an offering of securities of the Company the preparation of which had then been commenced, or (ii) the Company is in
possession of material non-public information the disclosure of which during the period specified in such notice the Board of Directors of the Company reasonably believes would not be in the best interests of the Company. 

Section 2.02. Piggyback Registration. (a) If the Company proposes to register any Common Shares under
the Securities Act (other than (i) a Shelf Registration, which will be subject to the provisions of Section 2.03; provided that any Underwritten Takedown will be subject to this Section 2.02, or (ii) a registration on Form S-8,
F-4 or S-4, or any successor or similar forms, relating to Common Shares issuable upon exercise of employee stock options or in connection with any employee benefit or similar plan of the Company or in connection with a direct or indirect
acquisition by the Company of another Person), whether or not for sale for its own account, the Company shall each such time give prompt notice at least five Business Days prior to the anticipated filing date of the registration statement relating
to such registration to each Shareholder, which notice shall set forth such Shareholder’s rights under this Section 2.02 and shall offer such Shareholder the opportunity to include in such registration statement the number of Registrable
Securities of the same class or series as those proposed to be registered as each such Shareholder may request (a “Piggyback Registration”). Any such Shareholder may, within two Business Days after the receipt of notice from the
Company, request that the Company also effect the registration under the Securities Act of all or any portion of such Shareholder’s Registrable Securities. Thereafter, subject to the provisions of Section 2.02(b), the Company shall use
commercially reasonable efforts to effect the registration under the Securities Act of all Registrable Securities that the Company has been so requested to register by all such Shareholders, to the extent necessary to permit the disposition of the
Registrable Securities so to be registered, provided that (A) if such registration involves a Public Offering, all such Shareholders requesting to be included in the Company’s registration must sell their Registrable
Securities to the underwriters selected as provided in Section 2.05(f) on the same terms and conditions as apply to the Company, and (B) if, at any time after giving notice of its intention to register any Common Shares pursuant to this
Section 2.02(a) and prior to the effective date of the registration statement filed in connection with such registration, the Company shall determine for any reason not to register such securities, the Company shall give notice to all
such Shareholders and, thereupon, shall be relieved of its obligation to register any Registrable Securities in connection with such registration. No registration effected under this Section 2.02 shall relieve the Company of its obligations to
effect a Demand Registration to the extent required by Section 2.01 or a Shelf Registration to the extent required by Section 2.03. The Company shall pay all Registration Expenses in connection with each Piggyback Registration. 

  
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 (b) If a Piggyback Registration involves a Public Offering and the managing underwriter advises
the Company that, in its view, the number of Shares that the Company and such Shareholders intend to include in such registration exceeds the Maximum Offering Size, the Company shall include in such registration, in the following priority, up to the
Maximum Offering Size: 
 (i) first, so much of the Common Shares proposed to be registered for the account of the Company as
would not cause the offering to exceed the Maximum Offering Size, 
 (ii) second, all Registrable Securities requested to be
included in such registration by any Shareholders pursuant to this Section 2.02 (allocated, if necessary for the offering not to exceed the Maximum Offering Size, pro rata among such Shareholders on the basis of the relative number of shares of
Registrable Securities so requested to be included in such registration by each such Shareholder; provided, that Warrant Shares shall be treated as "Registrable Securities" and holders of Warrant Shares shall be treated as "Shareholders" for the purpose of this Section 2.02(b)(ii) only), and 
 (iii) third, any
securities proposed to be registered for the account of any other Persons with such priorities among them as the Company shall determine; 
 provided,
however, that in no event shall the number of Shareholders’ Registrable Securities included in any such registration be reduced to less than 20% of the Maximum Offering Size if the number of Registrable Securities requested to be included
therein by Shareholders exceeds such amount. 
 Section 2.03. Shelf Registration. (a) At any
time after the first anniversary of the First Public Offering, if the Company is eligible to use Form F-3 or Form S-3, a Shareholder or group of Shareholders, in each case holding at least 10% of the Registrable Securities (the requesting
Shareholder(s) shall be referred to herein as the “Initial Shelf Requesting Shareholders”), may request the Company to effect a registration of some or all of the Registrable Securities held by such Initial Shelf Requesting
Shareholders under a Registration Statement pursuant to Rule 415 under the Securities Act (or any successor or similar rule) (a “Shelf Registration”). The Company shall give notice of such requested Shelf Registration to the other
Shareholders at least five Business Days prior to the anticipated filing date of the registration statement relating to such Shelf Registration. Such other Shareholders may, upon notice received by the Company no later than two Business Days after
the date of the notice of a Shelf Registration, request that the Company also effect a registration of some or all of the Registrable Securities held by such other Shareholders (such other requesting Shareholders, together with the Initial Shelf
Requesting Shareholders, the “Shelf Requesting Shareholders”). Thereafter, subject to the restrictions set forth in Section 2.01(e), the Company shall use commercially reasonable efforts to effect 


  
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the registration under the Securities Act of all Registrable Securities for which the Shelf Requesting Shareholders have requested registration under this Section 2.03 to the extent
necessary to permit the disposition of the Registrable Securities so to be registered on such Shelf Registration, provided that the Company shall be permitted to effect the registration under the Securities Act of any securities
other than the Registrable Securities (including for the benefit of Persons not party to this Agreement) as part of any Shelf Registration. The Company shall only be required to effectuate one Public Offering from such Shelf Registration (an
“Underwritten Takedown”) within any six-month period, which offering shall be deemed a Demand Registration for purposes of the Company’s obligation to effect no more than four Demand Registrations in the aggregate as set forth
in Section 2.01(a).  
 (b) The provisions of Section 2.01 shall apply mutatis mutandis to each Underwritten
Takedown except as otherwise provided in this Section 2.03, with references to “filing of the registration statement” or “effective date” being deemed references to filing of a prospectus or supplement for such offering,
references to “registration” being deemed references to the offering, references to “Demand Registration” being deemed references to “Shelf Registration” or “Underwritten Takedown” as applicable and references
to “Requesting Shareholders” being deemed references to “Shelf Requesting Shareholders”; provided that Shelf Requesting Shareholders shall only include Shareholders whose Registrable Securities are included in such Shelf
Registration or may be included therein without the need for an amendment to such Shelf Registration (other than an automatically effective amendment). So long as the Shelf Registration is effective, no Shareholder may request any Demand
Registration pursuant to Section 2.01 with respect to Registrable Securities that are registered or registrable without the need for an amendment (other than an automatically effective amendment) on such Shelf Registration. 

Section 2.04. Lock-Up Agreements. If any registration of Registrable Securities shall be effected in connection with a
Public Offering or any registration of securities by the Company shall be effected in connection with an underwritten public offering, each Shareholder agrees to not effect any public sale or distribution, including any sale pursuant to Rule 144, of
any Common Shares or other security of the Company (except as part of such Public Offering) during the period beginning 14 days prior to the effective date of the applicable registration statement or, in the case of an Underwritten Takedown, 14 days
prior to launch of the offering or such later date when the Shareholder receives notice thereof until the earlier of (i) such time as the Company and the lead managing underwriter shall agree and (ii) 90 days following the effective date
of the applicable registration statement or, in the case of a Shelf Registration, 90 days following the pricing of the offering, in each case as may be extended for purposes of compliance with NASD Rule 2711(f)(4), or any successor rule thereto
(such period, the “Lock-Up Period” for the applicable registration statement). 

  
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 Section 2.05. Registration Procedures. Whenever Shareholders request that any
Registrable Securities be registered pursuant to Section 2.01, 2.02, or 2.03, subject to the provisions of such Sections, the Company shall use commercially reasonable efforts to effect the registration and the sale of such Registrable Securities in
accordance with the intended method of disposition thereof as promptly as practicable, and, in connection with any such request: 

(a) The Company shall use commercially reasonable efforts to prepare and file with the SEC within 120 days of such request or such later date
as necessary to comply with applicable law, a registration statement on any form for which the Company then qualifies or that counsel for the Company shall deem appropriate and which form shall be available for the sale of the Registrable Securities
to be registered thereunder in accordance with the intended method of distribution thereof, and use commercially reasonable efforts to cause such filed registration statement to become and remain effective for a period of not less than 30 days, or
in the case of a Shelf Registration, three years (or such shorter period in which all of the Registrable Securities of the Shareholders included in such registration statement shall have actually been sold thereunder or cease to be Registrable
Securities). 
 (b) Prior to filing a registration statement or prospectus or any amendment or supplement thereto (other than any report
filed pursuant to the Exchange Act that is incorporated by reference therein), the Company shall, if requested, furnish to each participating Shareholder and each underwriter, if any, of the Registrable Securities covered by a registration statement
or prospectus or any amendments or supplements thereto copies of such registration statement, prospectus, amendment or supplement in the form as proposed to be filed, and thereafter the Company shall furnish to such Shareholder and underwriter, if
any, such number of copies of such registration statement, prospectus, amendment and supplement (in each case excluding all exhibits thereto and documents incorporated by reference therein unless specifically requested), the prospectus included in
such registration statement (including each preliminary prospectus and any summary prospectus) and any other prospectus filed under Rule 424, Rule 430A, Rule 430B or Rule 430C under the Securities Act as such Shareholder or underwriter may
reasonably request in order to facilitate the disposition of the Registrable Securities owned by such Shareholder. 
 (c) After the filing
of the registration statement, the Company shall (i) cause the related prospectus to be supplemented by any required prospectus supplement and, as so supplemented, to be filed pursuant to Rule 424 under the Securities Act, (ii) comply with
the provisions of the Securities Act with respect to the disposition of all Registrable Securities covered by such registration statement during the applicable period in accordance with the intended methods of disposition by the Shareholders thereof
set forth in such registration statement or supplement to such prospectus and (iii) promptly notify each Shareholder holding Registrable Securities covered by such registration statement of any stop order issued or threatened by the SEC or any
state securities commission and take all reasonable actions required to prevent the entry of such stop order or to remove it if entered. 

  
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 (d) The Company shall use commercially reasonable efforts to register or qualify the
Registrable Securities covered by such registration statement under such other securities or “blue sky” laws of such jurisdictions in the United States as any Shareholder holding such Registrable Securities reasonably (in light of such
Shareholder’s intended plan of distribution) requests; provided that the Company shall not be required to (A) qualify generally to do business in any jurisdiction where it would not otherwise be required to qualify but for this
Section 2.05(d), (B) subject itself to taxation in any such jurisdiction or (C) consent to general service of process in any such jurisdiction. 

(e) The Company shall as promptly as practicable notify each Shareholder holding such Registrable Securities covered by such registration
statement, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the occurrence of an event requiring the preparation of a supplement or amendment to such prospectus so that, as thereafter delivered
to the purchasers of such Registrable Securities, such prospectus will not contain an untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading and
promptly prepare and make available to each such Shareholder and file with the SEC any such supplement or amendment. 
 (f) The Company
shall have the right, in its sole discretion, to select an underwriter or underwriters in connection with any Public Offering resulting from any exercise of a Demand Registration or Underwritten Takedown. In connection with any Public Offering, the
Company shall enter into customary agreements (including an underwriting agreement in customary form) and take such all other actions as are reasonably required in order to expedite or facilitate the disposition of such Registrable Securities in any
such Public Offering, including if necessary in the judgment of Company counsel, the engagement of a “qualified independent underwriter” in connection with the qualification of the underwriting arrangements with FINRA. 

(g) Upon execution of confidentiality agreements in form and substance reasonably satisfactory to the Company, the Company shall, in
connection with a Public Offering make available for inspection by any Shareholder and any underwriter participating in such Public Offering and any attorney, accountant or other professional (the retention of which is reasonable under the
circumstances) retained by any such Shareholder or underwriter (collectively, the “Inspectors”), all financial and other records, pertinent corporate documents and properties of the Company (collectively, the
“Records”) as shall be reasonably necessary or desirable to enable any of the Inspectors to exercise its due diligence responsibility, and cause the Company’s officers, directors and employees to supply all information
reasonably requested by any Inspectors in connection with such Public Offering. Records that the Company determines in good faith to be  

  
 11 








 
confidential and that it notifies the Inspectors are confidential shall not be disclosed by the Inspectors unless (i) the disclosure of such Records is necessary to avoid or correct a
material misstatement or omission in the registration statement related to such Public Offering or (ii) the release of such Records is ordered pursuant to a subpoena or other order from a court of competent jurisdiction. Each Shareholder agrees
that information obtained by it as a result of such inspections shall be deemed confidential and shall not be used by it or its Affiliates as the basis for any market transactions in the Common Shares unless and until such information is made
generally available to the public. Each Shareholder further agrees that, upon learning that disclosure of such Records is sought in a court of competent jurisdiction, it shall give notice to the Company and allow the Company, at its expense, to
undertake appropriate action to prevent disclosure of the Records deemed confidential. 
 (h) In connection with any Public Offering, the
Company shall use commercially reasonable efforts to furnish to each underwriter, if any, a signed counterpart, addressed to such underwriter, of (i) an opinion or opinions of counsel to the Company and (ii) a comfort letter or comfort
letters from the Company’s independent public accountants, each in customary form and covering such matters of the kind customarily covered by opinions or comfort letters, as the case may be, as the managing underwriter(s) therefor reasonably
requests. 
 (i) The Company shall use commercially reasonable efforts to comply with all applicable rules and regulations of the SEC and
make available to its security holders, as soon as reasonably practicable, an earnings statement or such other document covering a period of 12 months, beginning within three months after the effective date of the registration statement, which
earnings statement satisfies the requirements of Rule 158 under the Securities Act. 
 (j) The Company may require each Shareholder promptly
to furnish in writing to the Company such information regarding the distribution of the Registrable Securities as the Company may from time to time reasonably request and such other information as may be legally required in connection with such
registration. In connection with a Shelf Registration, any Shareholder that does not provide such information within two Business Days of a request by the Company may have its Registrable Securities excluded from such Shelf Registration. 

(k) Each Shareholder agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in Section
2.05(e), such Shareholder shall forthwith discontinue disposition of Registrable Securities pursuant to the registration statement covering such Registrable Securities until such Shareholder’s receipt of the copies of the supplemented or
amended prospectus contemplated by Section 2.05(e), and, if so directed by the Company, such Shareholder shall deliver to the Company all copies, other than any permanent file copies then in such Shareholder’s possession, of the most recent
prospectus covering such Registrable Securities at the time of receipt of such 

  
 12 








 
notice. If the Company shall give such notice, the Company shall extend the period during which such registration statement shall be maintained effective (including the period referred to in
Section 2.05(a)) by the number of days during the period from and including the date of the giving of notice pursuant to Section 2.05(e) to the date when the Company shall make available to such Shareholder a prospectus supplemented or amended to
conform with the requirements of Section 2.05(e). 
 (l) The Company shall use commercially reasonable efforts to list all Registrable
Securities sold pursuant to an offering conducted pursuant to this Agreement on any securities exchange or quotation system on which the Common Shares are then listed or traded. 

(m) In any Public Offering conducted pursuant to a Demand Registration, the Company shall have appropriate officers of the Company
(i) prepare and make presentations at any “road shows” and before analysts and (ii) otherwise use their reasonable efforts to cooperate as reasonably requested by the underwriters in the offering, marketing or selling of the
Registrable Securities. 
 (n) Each Shareholder agrees that, in connection with any offering conducted pursuant to this Agreement, it will
not prepare or use or refer to, any “free writing prospectus” (as defined in Rule 405 of the Securities Act) without the prior written authorization of the Company (which authorization shall not be unreasonably withheld) and will not
distribute any written materials in connection with the offer or sale of the Registrable Securities pursuant to any Public Offering conducted hereunder other than the prospectus and any such free writing prospectus so authorized. 

Section 2.06. Participation In Public Offering. No Shareholder may participate in any Public Offering hereunder unless such
Shareholder (a) agrees to sell such Shareholder’s Registrable Securities on the basis provided in any underwriting arrangements approved by the Company and (b) completes and executes all questionnaires, powers of attorney,
indemnities, underwriting agreements and other documents reasonably required under the terms of such underwriting arrangements and the provisions of this Agreement in respect of registration rights. 

Section 2.07. Rule 144 Sales; Cooperation By The Company. If any Shareholder shall transfer any Registrable Securities
pursuant to Rule 144, the Company shall cooperate, to the extent commercially reasonable, with such Shareholder and shall provide to such Shareholder such information as such Shareholder shall reasonably request. Without limiting the foregoing, the
Company shall at any time after any of the Company’s Common Shares are registered under the Securities Act or the Exchange Act: (i) make and keep available public information, as those terms are contemplated by Rule 144; (ii) timely
file with the SEC all reports and other documents required to be filed under the Securities Act and the Exchange Act; and (iii) furnish to each  

  
 13 








 
Shareholder forthwith upon request a written statement by the Company as to its compliance with the reporting requirements of the Securities Act and the Exchange Act, a copy of the most recent
annual or quarterly report of the Company, and such other information as such Shareholder may reasonably request in order to avail itself of any rule or regulation of the SEC allowing such Shareholder to sell any Registrable Securities without
registration. 
 ARTICLE 3 

INDEMNIFICATION AND CONTRIBUTION 

Section 3.01. Indemnification by the Company. The Company agrees to indemnify and hold harmless each Shareholder holding
Registrable Securities covered by a registration statement, and all officers, directors and employees of such Shareholder, and each Person, if any, who controls such Shareholder within the meaning of Section 15 of the Securities Act or
Section 20 of the Exchange Act from and against any and all losses, claims, damages, liabilities and expenses (including reasonable and documented expenses of investigation and reasonable and documented attorneys’ fees and expenses)
(collectively, “Damages”) caused by or relating to any untrue statement or alleged untrue statement of a material fact contained in any registration statement or prospectus relating to the Registrable Securities (as
amended or supplemented if the Company shall have furnished any amendments or supplements thereto) or any preliminary prospectus, or caused by or relating to any omission or alleged omission to state therein a material fact required to be stated
therein or necessary to make the statements therein not misleading, except insofar as such Damages are caused by or related to any such untrue statement or omission or alleged untrue statement or omission so made based upon information furnished in
writing to the Company by such Shareholder or on such Shareholder’s behalf expressly for use therein. The Company also agrees to indemnify any underwriters of the Registrable Securities, their officers and directors and each Person who controls
such underwriters within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act on substantially the same basis as that of the indemnification of the Shareholders provided in this Section 3.01. 

Section 3.02. Indemnification by Participating Shareholders. (a) Each Shareholder holding Registrable Securities
covered by a registration statement agrees, severally but not jointly, to indemnify and hold harmless the Company, its officers, directors and agents and each Person, if any, who controls the Company within the meaning of Section 15 of the
Securities Act or Section 20 of the Exchange Act to the same extent as the indemnity from the Company to such Shareholder provided in Section 3.01, but only with respect to information furnished in writing by such Shareholder or on such
Shareholder’s behalf expressly for use in any registration statement or prospectus relating to the Registrable Securities, or any amendment or supplement thereto, or any preliminary prospectus. Each such Shareholder also agrees to indemnify and
hold harmless underwriters of the Registrable Securities, their officers and directors  

  
 14 








 
and each Person who controls such underwriters within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act on substantially the same basis as that of the
indemnification of the Company provided in this Section 3.02. 
 Section 3.03. Undertaking. As a condition to including
Registrable Securities in any registration statement filed in accordance with Article 2, the Company may require that it shall have received an undertaking reasonably satisfactory to it from any underwriter to indemnify and hold it harmless to the
extent customarily provided by underwriters with respect to similar securities 
 Section 3.04. Liability. No
Shareholder shall be liable for indemnification obligations under Section 3.02 for any Damages in excess of the net proceeds realized by such Shareholder in the sale of Registrable Securities of such Shareholder to which such Damages relate.

 Section 3.05. Conduct of Indemnification Proceedings. If any proceeding (including any governmental investigation)
shall be brought or asserted against any Person in respect of which indemnity may be sought pursuant to Section 3.01 or 3.02 such Person (an “Indemnified Party”) shall promptly notify the Person against whom such
indemnity may be sought (the “Indemnifying Party”) in writing and the Indemnifying Party shall assume the defense thereof, including the employment of counsel reasonably satisfactory to such Indemnified Party, and
shall assume the payment of all reasonable and documented fees and expenses, provided that the failure of any Indemnified Party so to notify the Indemnifying Party shall not relieve the Indemnifying Party of its obligations hereunder except
to the extent that the Indemnifying Party is materially prejudiced by such failure to notify. In any such proceeding, any Indemnified Party shall have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the
expense of such Indemnified Party unless (a) the Indemnifying Party and the Indemnified Party shall have mutually agreed to the retention of such counsel or (b) in the reasonable judgment of such Indemnified Party representation of both
parties by the same counsel would be inappropriate due to actual or potential differing interests between them, including one or more defenses or counterclaims that are different from or in addition to those available to the Indemnifying Party. It
is understood that, in connection with any proceeding or related proceedings in the same jurisdiction, the Indemnifying Party shall not be liable for the reasonable and documented fees and expenses of more than one separate firm of attorneys (in
addition to one local counsel per jurisdiction) at any time for all such Indemnified Parties, and that all such fees and expenses shall be reimbursed as they are incurred. In the case of any such separate firm for the Indemnified Parties, such firm
shall be designated in writing by the Indemnified Parties. The Indemnifying Party shall not be liable for any settlement of any proceeding effected without its written consent, but if settled with such consent, or if there be a final judgment for
the plaintiff, the Indemnifying Party shall indemnify and hold harmless such Indemnified Parties from and against any loss or liability (to the extent stated above) by reason of such settlement or judgment. Without the prior written consent of the
Indemnified Party, no Indemnifying Party shall effect any 

  
 15 








 
settlement of any pending or threatened proceeding in respect of which any Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such Indemnified
Party, unless such settlement includes an unconditional release of such Indemnified Party from all liability arising out of such proceeding. 

Section 3.06. Contribution. (a) If the indemnification provided for in Section 3.01 or 3.02 is unavailable to the
Indemnified Parties in respect of any Damages, then each Indemnifying Party, in lieu of indemnifying the Indemnified Parties, shall contribute to the amount paid or payable by such Indemnified Party, in such proportion as is appropriate to reflect
the relative fault of the Indemnifying Party and Indemnified Party in connection with the actions, statements or omissions that resulted in such Damages as well as any other relevant equitable considerations. The relative fault of such Indemnifying
Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact or omission or alleged omission of a material fact, has been
taken or made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such action, statement or omission.
The amount paid or payable by a party as a result of any Damages shall be deemed to include, subject to the limitations set forth in this Agreement, any reasonable attorneys’ or other reasonable fees or expenses incurred by such party in
connection with any proceeding to the extent such party would have been indemnified for such fees or expenses if the indemnification provided for in Sections 3.01 or 3.02 was available to such party in accordance with its terms. 

(b) The parties hereto agree that it would not be just and equitable if contribution pursuant to this Section 3.06 were determined by pro
rata allocation or by any other method of allocation that does not take into account the equitable considerations referred to in the immediately preceding paragraph. Notwithstanding the provisions of this Section 3.06, no Shareholder shall be
required to contribute, in the aggregate, any amount in excess of the amount by which the proceeds actually received by such Shareholder from the sale of the Registrable Securities subject to the proceeding exceeds the amount of any damages that
such Shareholder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission, except in the case of fraud by such Shareholder. Each Shareholder’s obligation to contribute pursuant to
this Section 3.06 is several in the proportion that the proceeds of the offering received by such Shareholder bears to the total proceeds of the offering received by all such Shareholders and not joint. No Person guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. The indemnity and contribution agreements contained in this
Article 3 are in addition to any liability that the Indemnifying Parties may have to the Indemnified Parties. 

  
 16 








 ARTICLE 4 

MISCELLANEOUS 

Section 4.01. Binding Effect; Assignability; Benefit. (a) This Agreement shall inure to the benefit of and be binding
upon the parties hereto and their respective heirs, successors, legal representatives and permitted assigns. Any Shareholder that ceases to own beneficially any Registrable Securities shall cease to be bound by the terms hereof (other than
(i) the provisions of Article 3 applicable to such Shareholder with respect to any offering of Registrable Securities completed before the date such Shareholder ceased to own any Registrable Securities and (ii) this Article 4). 

(b) Neither this Agreement nor any right, remedy, obligation or liability arising hereunder or by reason hereof shall be assignable by
any party hereto pursuant to any Transfer of Registrable Securities or otherwise, except that each Shareholder may assign all or any portion of its rights hereunder to any Permitted Transferee of such Shareholder with respect to not less than 5% of
the outstanding Common Shares at the time of such transfer; provided, however, that no such minimum share assignment requirement shall be necessary for an assignment by a Shareholder which is a
(i) partnership to its partners in accordance with their partnership interests, (ii) a limited liability company to its members in accordance with their interests in the limited liability company, (iii) a corporation to its
stockholders in accordance with their interests in the corporation or (iv) to an Affiliate of such Shareholder. Any such Permitted Transferee must (unless already bound hereby) execute and deliver to the Company an agreement to be bound by this
Agreement in the form of Exhibit A hereto (a “Joinder Agreement”) and shall thenceforth be a “Shareholder.” Any such transfer to a Permitted Transferee must be in compliance with the Securities Act and any other applicable
securities “blue sky” laws. 
 (c) Nothing in this Agreement, expressed or implied, is intended to confer on any Person
other than the parties hereto, and their respective heirs, successors, legal representatives and permitted assigns, any rights, remedies, obligations or liabilities under or by reason of this Agreement. 

Section 4.02. Notices. All notices, requests and other communications (each, a “Notice”) to
any party shall be in writing and shall be delivered in person, mailed by certified or registered mail, return receipt requested, or sent by facsimile transmission or email transmission, 

  
 17 








 if to the Company to: 

Affimed N.V. 

Technologiepark, Im Neuenheimer Feld 582 

69120 Heidelberg, Germany 

Fax: +49 (0) 6221-65307-77 

Attention: Florian Fischer, Chief Financial Officer 

Email: f.fischer@affimed.com 

with a copy to: 

Davis Polk & Wardwell LLP 

450 Lexington Avenue 

New York, New York 10017 

Attention: Richard D. Truesdell, Jr. 

Fax: (212) 701-5674 

Email: richard.truesdell@davispolk.com 

if to any Shareholder, at the address for such Shareholder listed on the signature pages below or otherwise provided to the Company as set
forth below. 
 Any Notice shall be deemed received on the date of receipt by the recipient thereof if received prior to 5:00 p.m. in the
place of receipt and such day is a Business Day in the place of receipt. Otherwise, such Notice shall be deemed not to have been received until the next succeeding Business Day in the place of receipt. Any Person that becomes a Shareholder after the
date hereof shall provide its address, fax number and email address to the Company. 
 Section 4.03. Waiver; Amendment;
Termination. (a) The provisions of this Agreement, including the provisions of this sentence, may not be amended, modified or supplemented, and waivers or consents to departures from the provisions hereof may not be given without the
written consent of the Company and holders of a majority of the Registrable Securities; provided, however, that in no event shall the obligations of any holder of Registrable Securities be materially increased or the rights of any Stockholder be
adversely affected (without similarly adversely affecting the rights of all Stockholders), except upon the written consent of such holder. Notwithstanding the foregoing, a waiver or consent to depart from the provisions hereof with respect to a
matter that relates exclusively to the rights of holders of Registrable Securities whose securities are being sold pursuant to a Registration Statement and that does not directly or indirectly affect the rights of other holders of Registrable
Securities may be given by holders of at least a majority of the Registrable Securities being sold by such holders pursuant to such Registration Statement. 

(b) This Agreement shall terminate upon the earlier to occur of (i) the fifth anniversary of the First Public Offering and (ii) the
date on which there are no Registrable Securities. 

  
 18 








 Section 4.04. Governing Law. This Agreement shall be governed by, and
construed and enforced in accordance with, the laws of the State of New York, without regard to the conflicts of laws rules of such state. 

Section 4.05. Jurisdiction. The parties hereby agree that any suit, action or proceeding seeking to enforce any provision of, or
based on any matter arising out of or in connection with, this Agreement or the transactions contemplated hereby shall be brought in any state or federal court in The City of New York, Borough of Manhattan, so long as one of such courts shall have
subject matter jurisdiction over such suit, action or proceeding, and that any cause of action arising out of this Agreement shall be deemed to have arisen from a transaction of business in the State of New York, and each of the parties hereby
irrevocably consents to the jurisdiction of such courts (and of the appropriate appellate courts therefrom) in any such suit, action or proceeding and irrevocably waives, to the fullest extent permitted by law, any objection that it may now or
hereafter have to the laying of the venue of any such suit, action or proceeding in any such court or that any such suit, action or proceeding which is brought in any such court has been brought in an inconvenient forum. Process in any such suit,
action or proceeding may be served on any party anywhere in the world, whether within or without the jurisdiction of any such court. Without limiting the foregoing, each party agrees that service of process on such party as provided in
Section 4.02 shall be deemed effective service of process on such party. 
 Section 4.06. WAIVER OF JURY TRIAL. EACH
OF THE PARTIES HERETO HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATED TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

Section 4.07. Specific Enforcement. Each party hereto acknowledges that the remedies at law of the other parties for a
breach or threatened breach of this Agreement would be inadequate and, in recognition of this fact, any party to this Agreement, without posting any bond or furnishing other security, and in addition to all other remedies that may be available,
shall be entitled to obtain equitable relief in the form of specific performance, a temporary restraining order, a temporary or permanent injunction or any other equitable remedy that may then be available. 

Section 4.08. Counterparts; Effectiveness. This Agreement may be executed (including by facsimile or other electronic image
scan transmission) with counterpart signature pages or in any number of counterparts, each of which shall be deemed to be an original, and all of which shall, taken together, be considered one and the same agreement, it being understood that each
party need not sign the same counterpart. This Agreement shall become effective when each party hereto shall have executed and delivered this Agreement. Until and unless each party has executed and delivered this Agreement, this Agreement shall have
no effect and no party shall have any right or obligation hereunder (whether by virtue of any other oral or written agreement or other communication). 

  
 19 








 Section 4.09. Entire Agreement. This Agreement constitutes the entire
agreement and understanding among the parties hereto with respect to the subject matter of this Agreement and supersedes all prior and contemporaneous agreements and understandings, both oral and written, among the parties hereto with respect to the
subject matter hereof. 
 Section 4.10. Severability. If any term, provision, covenant or restriction of this
Agreement is held by a court of competent jurisdiction or other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect and shall in
no way be affected, impaired or invalidated so long as the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such a determination, the parties shall negotiate in
good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner so that the transactions contemplated hereby be consummated as originally contemplated to the fullest extent
possible. 
 Section 4.11. Confidentiality. Each Shareholder agrees that any notice received pursuant to this Agreement,
including any notice of a proposed public offering, postponement of an offering or other similar notice regarding the Company’s securities, is confidential information and that any trading in securities of the Company following receipt of such
information may only be done in compliance with all applicable securities laws. 
 Section 4.12. Independent Nature of
Shareholders’ Obligations and Rights. The obligations of each Shareholder hereunder are several and not joint with the obligations of any other Shareholder hereunder, and no Shareholder shall be responsible in any way for the performance of
the obligations of any other Shareholder hereunder. Nothing contained herein or in any other agreement or document delivered at any closing, and no action taken by any Shareholder pursuant hereto or thereto, shall be deemed to constitute the
Shareholders as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Shareholders are in any way acting in concert with respect to such obligations or the transactions contemplated by this
Agreement. Each Shareholder shall be entitled to protect and enforce its rights, including the rights arising out of this Agreement, and it shall not be necessary for any other Shareholder to be joined as an additional party in any proceeding for
such purpose. 
 [Signature pages follow.] 

  
 20 








 IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement or have caused this
Agreement to be duly executed by their respective authorized officers as of the day and year first above written. 
  

			
	AFFIMED N.V.
		
	By:	 	 /s/ Adi Hoess 

		 	Name: Adi Hoess
		 	Title: Chief Executive Officer
		
	By:	 	 /s/ Florian Fischer

		 	Name: Florian Fischer
		 	Title: Chief Financial Officer


 [Signature page to the Registration Rights Agreement] 

  
 1 








 
			
	ORBIMED ASSOCIATES III, LP
		
	 By:
	 	 OrbiMed Advisors LLC,
 its General
Partner

		
	 By:
	 	 /s/ W. Carter Neild

	 Name:
	 	W. Carter Neild
	 Title:
	 	Member


 AND 

 

			
	ORBIMED PRIVATE INVESTMENTS III, LP
		
	 By:
	 	 OrbiMed Capital GP III LLC,
 its General
Partner

		
	 By:
	 	 OrbiMed Advisors LLC,
 its Managing
Member

		
	 By:
	 	 /s/ W. Carter Neild

	 Name:
	 	W. Carter Neild
	 Title:
	 	Member


 Address for Notices: 

Address: 
 Fax number: 

Email address: 

  
 2 








 
			
	SGR SAGITTARIUS HOLDING AG
		
	By:	 	 /s/ Hans Schaefer

	Name:	 	Dr. Hans Schaefer
	Title:	 	Attorney-at-law


 Address for Notices: 

Address: 
 Fax number: 

Email address: 

  
 3 








 
			
	BIOMED INVEST I LIMITED
		
	By:	 	 /s/ Kevin Gilligan

	Name:	 	Kevin Gilligan
	Title:	 	Director


 Address for Notices: 

Address: 
 Fax number: 

Email address: 

  
 4 








 
			
	LSP III OMNI INVESTMENT COÖPERATIEF U.A.
		
	By:	 	 /s/ Martijn Kleijwegt and Rene R. Kuijten

	Name:	 	Martijn Kleijwegt and Rene R. Kuijten
	Title:	 	Directors of LSP III Management B.V., Director of LSP III Omni Investment Coöperatief U.A.


 Address for Notices: 

Address: 
 Fax number: 

Email address: 

  
 5 








 
			
	NOVO NORDISK A/S
		
	By:	 	 /s/ Peter Haahr

	Name:	 	Peter Haahr
	Title:	 	CUP


 Address for Notices: 

Address: 
 Fax number: 

Email address: 

  
 6 








 EXHIBIT A 

JOINDER TO REGISTRATION RIGHTS AGREEMENT 

This Joinder Agreement (this “Joinder Agreement”) is made as of the date written below by the undersigned (the
“Joining Party”) in accordance with the Registration Rights Agreement dated as of [            ], 2014 (as the same may be amended from time to time, the
“Registration Rights Agreement”), by and among Affimed N.V. and the shareholders party thereto listed on the signature pages, as well as any Permitted Transferees. Capitalized terms used, but not defined, herein shall have the
meaning ascribed to such terms in the Registration Rights Agreement. 
 The Joining Party hereby acknowledges, agrees and confirms
that, by its execution of this Joinder Agreement, the Joining Party shall be deemed to be a party to the Registration Rights Agreement as of the date hereof as a Permitted Transferee of a Shareholder thereto, and shall have all of the rights and
obligations of a “Shareholder” thereunder as if it had executed the Registration Rights Agreement. The Joining Party hereby ratifies, as of the date hereof, and agrees to be bound by, all of the terms, provisions and conditions contained
in the Registration Rights Agreement. 
 IN WITNESS WHEREOF, the undersigned has executed this Joinder Agreement as of the date written
below. 
 Date:                     
    ,              
  

			
	 [NAME OF JOINING PARTY]

		
	By:	 	  

	Name:	 	
	Title:	 	


  

			
	Address for Notices:	 	
	[Address]	 	
	[Fax number]	 	
	[Email address]