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NIOSH Radiation Dose Reconstruction Program








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				NIOSH-IREP Software						Print
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			Access and UseTechnical DocumentationSubject Matter Expert ReviewPrevious VersionsSubmitting CommentsFrequently Asked Questions (FAQs)
		
To determine probability of causation for a cancer case under the Act, the Department of Labor (DOL) uses a computer software application NIOSH has developed in collaboration with the National Cancer Institute, called NIOSH-IREP (Interactive RadioEpidemiological Program).
NIOSH-IREP was adapted from the National Institutes of Health’s (NIH) Interactive RadioEpidemiological Program (NIH-IREP) developed by the National Cancer Institute (NCI) to update the 1985 NIH Radioepidemiological Tables.
NIOSH-IREP is a science-based tool that allows DOL to determine the probability a cancer was caused by a person’s radiation dose from nuclear weapons production work. The actual outcome of a case depends on a number of important factors such as the dose estimates of past exposures and the type of cancer that has been diagnosed. NIOSH is responsible for maintaining and updating this software and the scientific elements (cancer risk models) that it uses.
Access and Use
Online Access
The NIOSH-IREP interactive software program can be found at: https://irep.oraucoc.org. Data can be entered manually or by using a NIOSH-provided input file. Users also have the ability to calculate PC from multiple primary cancers.
User’s Guide
User’s Guide Version 5.9 [902 KB (22 pages)]
            (December 2020)
            Recently, an issue with the Acute Lymphocytic Leukemia cancer model was found, and it is now corrected in the IREP version v.5.9. Here is a complete description with all the changes that were made in NIOSH-IREP v.5.9:
**Fixed issue related to Acute Lymphocytic Leukemia claims**
                        A small issue was identified and fixed related to Acute Lymphocytic Leukemia claims involving exposures to neutrons or alpha particles. Claims evaluated using v.5.9 will result in slight changes in PC values, with a tendency towards larger PC values for claims involving exposures to neutrons and towards lower PC values for claims involving exposures to alpha particles.
**Improved Validation Checks**
                        This version includes additional validation checks on user input to provide friendly warnings or messages when invalid inputs are entered.Example Input Files
Below are example input files that may be uploaded into NIOSH-IREP. The User’s Guide provides instructions for uploading input files. Summaries of the example files are also provided. To work properly, the files must first be saved to a disk or to your computer. From there, they can be uploaded directly into the program.
Example 1a [(Microsoft Excel File; 169 KB)]
Example 1b [(Microsoft Excel File; 169 KB)]
Example 2a [(Microsoft Excel File; 169 KB)]
Example 2b [(Microsoft Excel File; 169 KB)]
Example 3 [(Microsoft Excel File; 169 KB)]
Example 4 [(Microsoft Excel File; 169 KB)]Technical Documentation
NCI-CDC Working Group to Revise the 1985 NIH Radioepidemiological Tables [1.4 MB (126 pages)]
NIOSH-IREP Technical Documentation [2.01 MB (77 pages)]
Pages i-20 [664 KB (24 pages)]
Pages 21-50 [771 KB (30 pages)]
Pages 51-73 [650 KB (23 pages)]
Radiation Effectiveness Factors (REFs) for Use in Calculating Probability of Causation of Radiogenic Cancers [4.41 MB (77 pages)]
Pages 1-15 [896 KB (15 pages)]
Pages 16-30 [814 KB (15 pages)]
Pages 31-45 [996 KB (15 pages)]
Pages 46-60 [944 KB (15 pages)]
Pages 61-77 [883 KB (17 pages)]Subject Matter Expert Review
Comments from David G. Hoel, Ph.D., University Professor, Medical University of South Carolina. [157 KB (6 pages)]
Comments from Richard Hornung, University of Cincinnati. [157 KB (4 pages)]
Comments from David Richardson, Department of Epidemiology, School of Public Health, University of North Carolina. [52 KB (6 pages)]
Comments from Roy E. Shore, Ph.D., Dr. P.H., Professor, Department of Environmental Medicine, Director, Division of Epidemiology and Biostatistics, New York University, School of Medicine. [164 KB (4 pages)]
Comments from Daniel O. Stram, Ph.D., Associate Professor, Keck School of Medicine, Department of Preventive Medicine, Division of Biostatistics, University of Southern California. [439 KB (5 pages)]
Response to Subject Matter Expert Review Comments on NIOSH-IREP [917 KB (27 pages)]Previous Versions
Information on previous updates to the NIOSH-IREP program can be found at https://irep.oraucoc.org/update.asp.
Submitting Comments
The public may comment on NIOSH-IREP at any time. Comments can be sent by e-mail to dcas@cdc.gov.
Comments can be mailed to:
NIOSH-IREP Comments
    National Institute for Occupational Safety and Health
    Division of Compensation Analysis and Support
    1090 Tusculum Avenue, Mailstop C-45
    Cincinnati, Ohio 45226
Frequently Asked Questions (FAQs)
More information on NIOSH-IREP can be found on the FAQs: NIOSH-Interactive RadioEpidemiological Program (NIOSH-IREP) page of our website.
							
					
							Last Reviewed:  June 30, 2022						Source: 	National Institute for Occupational Safety and Health
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        Syndicate homeRadiation Dose ReconstructionAbout DCASThe Act/EEOICPADose Reconstruction (DR)plus iconDataplus iconSourcesFormats & TypesSensitive DataWork History                            Phone CallData Search and Capture EffortsMethodsProductionTechnical Documents Used in Dose ReconstructionsProgram Evaluation Reports and PlansQuality Assurance and Quality ControlSupport ContractorSoftware (IMBA)RECA ClaimsProbability of Causationplus iconCalculating PCNews & UpdatesNIOSH-IREP SoftwareSpecial Exposure Cohortplus iconSubmit a PetitionCheck Petition Statusplus iconSEC Status TableGet HelpResidual ContaminationAdvisory Boardplus iconPublic MeetingsSubcommittee and Work GroupsSEC Petition RecommendationsTechnical Support for the Review of NIOSH Dose Reconstruction ProgramReports from the Advisory Board's Technical Support ContractorTechnical Review Summaries from the Technical Support ContractorProceduresCorrespondenceWork Site InformationPublications & ProductsProgram ReviewsReports to CongressPolicies, Procedures, and GuidelinesNIOSH Public DocketRelated Program LinksContact UsHELPplus iconHelp A – ZAccessibilityAcronymsFrequently Asked Questions (FAQs)plus iconThe ActCase ConcernsClaimant CorrespondenceConflict or BiasDose ReconstructionFreedom of Information Act (FOIA)National Defense Authorization ActNIOSH-IREPProbability of CausationResidual Contamination ReportResponsibilities under Subtitle B of EEOICPA (The Act)Special Exposure CohortTechnical DocumentsWork History Phone CallGlossary Follow NIOSH Facebook
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