# Patent

## Title
Compositions and methods for inhibiting expression of GSK-3 genes

## Abstract

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.

## Background
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of U.S. patent application Ser. No. 13/003,740 filed Jun. 13, 20009, which is a 371 national phase of PCT patent application serial number PCT/US2009/050432, filed Jul. 13, 2009, which claims the benefit of U.S. Provisional Application No. 61/080,153, filed Jul. 11, 2008, which are hereby incorporated in their entirety by reference.


STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
None.
FIELD OF THE INVENTION
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 alpha and/or beta (GSK-3 alpha and/or beta), and methods of using the dsRNA to inhibit expression of GSK-3. alpha and/or beta.
BACKGROUND OF THE INVENTION
Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine kinase. It functions as a key regulator of numerous signaling pathways. It phosphorylates and inactivates glycogen synthase, a key enzyme in glycogen metabolism. It has also been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. Two isoforms of GSK-3 have been reported in mammals: an approximately 51 kDa GSK-3 alpha form and an approximately 47 kDa GSK-3 beta form. These two isoforms exhibit about 98% homology in their kinase domains. Other regions share less homology: they share only about 36% identity in the last 76 C-terminal amino acid residues.
Double-stranded RNA molecules (dsRNA) have been shown to block gene expression in a highly conserved regulatory mechanism known as RNA interference (RNAi). WO 99/32619 (Fire et al.) disclosed the use of a dsRNA of at least 25 nucleotides in length to inhibit the expression of genes in C. elegans. dsRNA has also been shown to degrade target RNA in other organisms, including plants (see, e.g., WO 99/53050, Waterhouse et al.; and WO 99/61631, Heifetz et al.), Drosophila (see, e.g., Yang, D., et al., Curr. Biol. (2000) 10:1191-1200), and mammals (see WO 00/44895, Limmer; and DE 101 00 586.5, Kreutzer et al.).
SUMMARY OF THE INVENTION
The invention provides compositions containing double-stranded ribonucleic acid (dsRNA) targeted to a GSK-3 gene and methods for inhibiting the expression of a GSK-3 gene in a cell or mammal. The composition can inhibit GSK-3 alpha and/or GSK-3 beta. A composition that inhibits both can do so, e.g., by including a dsRNA that targets both GSK-3 alpha and GSK-3 beta, or by including a first dsRNA that inhibits GSK-3 alpha and a second dsRNA that inhibits GSK-3 beta. The composition can also include a dsRNA which inhibits both and a second which inhibits only one of the isoforms.
The invention also provides compositions and methods for treating manic depression (bipolar disorder).
Other disorders, e.g., pathological conditions and diseases caused by the expression of a GSK-3 gene, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS and nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, bipolar disorder, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), are also provided. The dsRNAs described herein can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.
In one embodiment the invention provides a double-stranded ribonucleic acid (dsRNA), having a sense strand and an antisense strand, the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to an mRNA encoding a GSK-3 gene, and wherein said region of complementarity is less than 30 nucleotides in length. In some embodiments, the second sequence includes a region complementary to the GSK-3 gene sequences NM—019884, NM—00103166, :NM—002093, or NM—019827. In other embodiments, the second sequence includes a region complementary to at least 15 nucleotides of a target sequence described herein, e.g., in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. The second sequence can include a region complementary to a target sequence described in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The antisense strand of the dsRNA of the invention can include at least 15 nucleotides of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In one embodiment, the antisense strand includes one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In another embodiment, the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The sense strand can include at least 15 nucleotides of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. For example, the sense strand can include or can consist of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
In some embodiments, the dsRNA of the invention consists of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 and the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Further embodiments include the duplexes disclosed herein, e.g., huGSKA-3, huGSKB-11, AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, or AD-18844.
The dsRNA of the invention can include at least one modified nucleotide. Disclosed herein are exemplary modified sequences, but one of skill can readily design duplexes with different set of modifications using the sequences and teachings herein. The modified nucleotides can be, e.g., a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, or a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group. The modified nucleotide(s) can be a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide. In one embodiment the dsRNA of the invention includes at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.
The region of complementarity of the dsRNA of the invention is less than 30 nucleotides, e.g., at least 15 nucleotides in length, or, e.g., between 19 and 21 nucleotides in length, or, e.g., 19 nucleotides in length.
Disclosed and claimed herein are methods for inhibiting expression of a GSK-3 gene. In one embodiment, administration of the dsRNA inhibits expression of GSK3 by more than 40%. In another embodiment the dsRNA exhibits an IC50 of less than or equal to 10 nM in suppressing GSK3. Alternatively, the dsRNA exhibits an IC50 of less than or equal to 1.0 nM in suppressing GSK3.
Also included in the invention are cells and vectors comprising the dsRNA of the invention.
Further contemplated is a pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising a dsRNA of the invention.
Methods of inhibiting GSK-3 expression in a cell are included in the invention. The methods include (a) introducing into the cell the dsRNA of the invention; and (b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.
Also included is a method of treating a disorder mediated by GSK-3 expression comprising administering to a human in need of such treatment a therapeutically effective amount of a dsRNA of the invention, including treatment of manic depression.



BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS
These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:
FIG. 1 is a graph illustrating the results of GSK3α mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.
FIG. 2 is a graph illustrating the results of GSK3β mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.
FIG. 3 is a graph illustrating the dose dependence of GSK3α mRNA suppression after siRNA transfection of HT22 cells.
FIG. 4 is a graph illustrating the dose dependence of GSK3 β mRNA suppression after siRNA transfection of HT22 cells.
FIG. 5 is a western blot illustrating protein levels after siRNA transfection in HT22 cells.
FIG. 6 is a graph illustrating GSK3β mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18844 into the nucleus accumbens.
FIG. 7 is a graph illustrating GSK3α mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18826 into the nucleus accumbens.



DETAILED DESCRIPTION OF THE INVENTION
The invention provides dsRNAs and methods of using the dsRNAs for inhibiting the expression of a GSK-3 gene in a cell or a mammal where the dsRNA targets a GSK-3 gene. The invention also provides compositions and methods for treating pathological conditions and diseases, such as a metabolic disease or a cardiovascular disease, in a mammal caused by the expression of a GSK-3 gene. dsRNA directs the sequence-specific degradation of mRNA through a process known as RNA interference (RNAi).
The dsRNAs of the compositions featured herein include an RNA strand (the antisense strand) having a region which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an mRNA transcript of a GSK-3 gene. The use of these dsRNAs enables the targeted degradation of mRNAs of genes that are implicated in replication and or maintenance of cancer cells in mammals. Very low dosages of GSK-3 dsRNAs in particular can specifically and efficiently mediate RNAi, resulting in significant inhibition of expression of the GSK-3 gene. The methods and compositions of the invention containing the GSK-3 dsRNA are useful for treating pathological processes mediated by GSK-3 expression, e.g., manic depression, or other disorders described herein.
The following detailed description discloses how to make and use the compositions containing dsRNAs to inhibit the expression of a GSK-3 gene, as well as compositions and methods for treating diseases and disorders caused by the expression of these genes, such as manic depression. The pharmaceutical compositions featured in the invention include a dsRNA having an antisense strand comprising a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene, together with a pharmaceutically acceptable carrier. The compositions featured in the invention also include a dsRNA having an antisense strand having a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene.
Accordingly, certain aspects of the invention provide pharmaceutical compositions containing the GSK-3 dsRNA and a pharmaceutically acceptable carrier, methods of using the compositions to inhibit expression of a GSK-3 gene, and methods of using the pharmaceutical compositions to treat diseases caused by expression of the GSK-3 gene.
I. DEFINITIONS
For convenience, the meaning of certain terms and phrases used in the specification, examples, and appended claims, are provided below. If there is an apparent discrepancy between the usage of a term in other parts of this specification and its definition provided in this section, the definition in this section shall prevail.
“G,” “C,” “A” and “U” each generally stand for a nucleotide that contains guanine, cytosine, adenine, and uracil as a base, respectively. “T” and “dT” are used interchangeably herein and refer to a deoxyribonucleotide wherein the nucleobase is thymine, e.g., deoxyribothymine. However, it will be understood that the term “ribonucleotide” or “nucleotide” or “deoxyribonucleotide” can also refer to a modified nucleotide, as further detailed below, or a surrogate replacement moiety. The skilled person is well aware that guanine, cytosine, adenine, and uracil may be replaced by other moieties without substantially altering the base pairing properties of an oligonucleotide comprising a nucleotide bearing such replacement moiety. For example, without limitation, a nucleotide comprising inosine as its base may base pair with nucleotides containing adenine, cytosine, or uracil. Hence, nucleotides containing uracil, guanine, or adenine may be replaced in the nucleotide sequences of the invention by a nucleotide containing, for example, inosine. Sequences comprising such replacement moieties are embodiments of the invention.
As used herein, “GSK-3” refers to Glycogen Synthase Kinase-3, which is also known as DKFZp686D0638, GSK3, C86142, GSK-3beta, 7330414F15Rik, and 8430431H08Rik. GSK-3 alpha sequence can be found as NCBI GeneID:2931 (human) and 606496 (mouse) and RefSeq ID number:NM—019884 (human) and NM—001031667 (mouse). GSK-3 beta sequence can be found as NCBI GeneID:2932 (human) and 56637 (mouse) and RefSeq ID number:NM—002093 (human) and NM—019827 (mouse). A dsRNA featured in the invention can target a specific GSK-3 isoform, e.g. GSK-3 alpha or GSK-3 beta, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript. A dsRNA featured in the invention can target a specific GSK-3 beta isoform, e.g. GSK-3 beta 1 or GSK-3 beta 2, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript.
As used herein, “target sequence” refers to a contiguous portion of the nucleotide sequence of an mRNA molecule formed during the transcription of a GSK-3 gene, including mRNA that is a product of RNA processing of a primary transcription product.
As used herein, the term “strand comprising a sequence” refers to an oligonucleotide comprising a chain of nucleotides that is described by the sequence referred to using the standard nucleotide nomenclature.
As used herein, and unless otherwise indicated, the term “complementary,” when used to describe a first nucleotide sequence in relation to a second nucleotide sequence, refers to the ability of an oligonucleotide or polynucleotide comprising the first nucleotide sequence to hybridize and form a duplex structure under certain conditions with an oligonucleotide or polynucleotide comprising the second nucleotide sequence, as will be understood by the skilled person. Such conditions can, for example, be stringent conditions, where stringent conditions may include: 400 mM NaCl, 40 mM PIPES pH 6.4, 1 mM EDTA, 50° C. or 70° C. for 12-16 hours followed by washing. Other conditions, such as physiologically relevant conditions as may be encountered inside an organism, can apply. The skilled person will be able to determine the set of conditions most appropriate for a test of complementarity of two sequences in accordance with the ultimate application of the hybridized nucleotides.
This includes base-pairing of the oligonucleotide or polynucleotide comprising the first nucleotide sequence to the oligonucleotide or polynucleotide comprising the second nucleotide sequence over the entire length of the first and second nucleotide sequence. Such sequences can be referred to as “fully complementary” with respect to each other herein. However, where a first sequence is referred to as “substantially complementary” with respect to a second sequence herein, the two sequences can be fully complementary, or they may form one or more, but generally not more than 4, 3 or 2 mismatched base pairs upon hybridization, while retaining the ability to hybridize under the conditions most relevant to their ultimate application. However, where two oligonucleotides are designed to form, upon hybridization, one or more single stranded overhangs, such overhangs shall not be regarded as mismatches with regard to the determination of complementarity. For example, a dsRNA comprising one oligonucleotide 21 nucleotides in length and another oligonucleotide 23 nucleotides in length, wherein the longer oligonucleotide comprises a sequence of 21 nucleotides that is fully complementary to the shorter oligonucleotide, may yet be referred to as “fully complementary” for the purposes of the invention.
“Complementary” sequences, as used herein, may also include, or be formed entirely from, non-Watson-Crick base pairs and/or base pairs formed from non-natural and modified nucleotides, in as far as the above requirements with respect to their ability to hybridize are fulfilled. Such non-Watson-Crick base pairs includes, but not limited to, G:U Wobble or Hoogstein base pairing.
The terms “complementary”, “fully complementary” and “substantially complementary” herein may be used with respect to the base matching between the sense strand and the antisense strand of a dsRNA, or between the antisense strand of a dsRNA and a target sequence, as will be understood from the context of their use.
As used herein, a polynucleotide which is “substantially complementary to at least part of” a messenger RNA (mRNA) refers to a polynucleotide which is substantially complementary to a contiguous portion of the mRNA of interest (e.g., encoding a GSK-3) including a 5′ UTR, an open reading frame (ORF), or a 3′ UTR. For example, a polynucleotide is complementary to at least a part of a GSK-3 mRNA if the sequence is substantially complementary to a non-interrupted portion of an mRNA encoding a GSK-3.
The term “double-stranded RNA” or “dsRNA”, as used herein, refers to a complex of ribonucleic acid molecules, having a duplex structure comprising two anti-parallel and substantially complementary, as defined above, nucleic acid strands. In general, the majority of nucleotides of each strand are ribonucleotides, but as described in detail herein, each or both strands can also include at least one non-ribonucleotide, e.g., a deoxyribonucleotide and/or a modified nucleotide. In addition, as used in this specification, “dsRNA” may include chemical modifications to ribonucleotides, including substantial modifications at multiple nucleotides and including all types of modifications disclosed herein or known in the art. Any such modifications, as used in an siRNA type molecule, are encompassed by “dsRNA” for the purposes of this specification and claims. The two strands forming the duplex structure may be different portions of one larger RNA molecule, or they may be separate RNA molecules. Where the two strands are part of one larger molecule, and therefore are connected by an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′ end of the respective other strand forming the duplex structure, the connecting RNA chain is referred to as a “hairpin loop”. Where the two strands are connected covalently by means other than an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′ end of the respective other strand forming the duplex structure, the connecting structure is referred to as a “linker”. The RNA strands may have the same or a different number of nucleotides. The maximum number of base pairs is the number of nucleotides in the shortest strand of the dsRNA minus any overhangs that are present in the duplex. In addition to the duplex structure, a dsRNA may comprise one or more nucleotide overhangs.
As used herein, a “nucleotide overhang” refers to the unpaired nucleotide or nucleotides that protrude from the duplex structure of a dsRNA when a 3′-end of one strand of the dsRNA extends beyond the 5′-end of the other strand, or vice versa. “Blunt” or “blunt end” means that there are no unpaired nucleotides at that end of the dsRNA, i.e., no nucleotide overhang. A “blunt ended” dsRNA is a dsRNA that is double-stranded over its entire length, i.e., no nucleotide overhang at either end of the molecule.
The term “antisense strand” refers to the strand of a dsRNA which includes a region that is substantially complementary to a target sequence. As used herein, the term “region of complementarity” refers to the region on the antisense strand that is substantially complementary to a sequence, for example a target sequence, as defined herein. Where the region of complementarity is not fully complementary to the target sequence, the mismatches are most tolerated in the terminal regions and, if present, are generally in a terminal region or regions, e.g., within 6, 5, 4, 3, or 2 nucleotides of the 5′ and/or 3′ terminus.
The term “sense strand,” as used herein, refers to the strand of a dsRNA that includes a region that is substantially complementary to a region of the antisense strand.
“Introducing into a cell”, when referring to a dsRNA, means facilitating uptake or absorption into the cell, as is understood by those skilled in the art. Absorption or uptake of dsRNA can occur through unaided diffusive or active cellular processes, or by auxiliary agents or devices. The meaning of this term is not limited to cells in vitro; a dsRNA may also be “introduced into a cell”, wherein the cell is part of a living organism. In such instance, introduction into the cell will include the delivery to the organism. For example, for in vivo delivery, dsRNA can be injected into a tissue site or administered systemically. In vitro introduction into a cell includes methods known in the art such as electroporation and lipofection.
The terms “silence” and “inhibit the expression of” “down-regulate the expression of,” “suppress the expression of” and the like in as far as they refer to a GSK-3 gene, herein refer to the at least partial suppression of the expression of a GSK-3 gene, as manifested by a reduction of the amount of mRNA which may be isolated from a first cell or group of cells in which a GSK-3 gene is transcribed and which has or have been treated such that the expression of a GSK-3 gene is inhibited, as compared to a second cell or group of cells substantially identical to the first cell or group of cells but which has or have not been so treated (control cells). The degree of inhibition is usually expressed in terms of




  
    
      
        
          
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Alternatively, the degree of inhibition may be given in terms of a reduction of a parameter that is functionally linked to GSK-3 gene transcription, e.g., the amount of protein encoded by a GSK-3 gene which is secreted by a cell, or the number of cells displaying a certain phenotype, e.g., apoptosis. In principle, GSK-3 gene silencing may be determined in any cell expressing the target, either constitutively or by genomic engineering, and by any appropriate assay. However, when a reference is needed in order to determine whether a given dsRNA inhibits the expression of the GSK-3 gene by a certain degree and therefore is encompassed by the instant invention, the assay provided in the Examples below shall serve as such reference.
For example, in certain instances, expression of a GSK-3 gene is suppressed by at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 60%, 70%, or 80% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 85%, 90%, or 95% by administration of the double-stranded oligonucleotide of the invention.
As used herein in the context of GSK-3 expression, the terms “treat”, “treatment”, and the like, refer to relief from or alleviation of pathological processes mediated by GSK-3 expression. In the context of the present invention insofar as it relates to any of the other conditions recited herein below (other than pathological processes mediated by GSK-3 expression), the terms “treat”, “treatment”, and the like mean to relieve or alleviate at least one symptom associated with such condition, or to slow or reverse the progression of such condition, such as the slowing and progression of manic depression.
As used herein, the phrases “therapeutically effective amount” and “prophylactically effective amount” refer to an amount that provides a therapeutic benefit in the treatment, prevention, or management of pathological processes mediated by GSK-3 expression or an overt symptom of pathological processes mediated by GSK-3 expression. The specific amount that is therapeutically effective can be readily determined by ordinary medical practitioner, and may vary depending on factors known in the art, such as, e.g. the type of pathological processes mediated by GSK-3 expression, the patient's history and age, the stage of pathological processes mediated by GSK-3 expression, and the administration of other anti-pathological processes mediated by GSK-3 expression agents.
As used herein, a “pharmaceutical composition” comprises a pharmacologically effective amount of a dsRNA and a pharmaceutically acceptable carrier. As used herein, “pharmacologically effective amount,” “therapeutically effective amount” or simply “effective amount” refers to that amount of an RNA effective to produce the intended pharmacological, therapeutic or preventive result. For example, if a given clinical treatment is considered effective when there is at least a 25% reduction in a measurable parameter associated with a disease or disorder, a therapeutically effective amount of a drug for the treatment of that disease or disorder is the amount necessary to effect at least a 25% reduction in that parameter.
The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent. Such carriers include, but are not limited to, saline, buffered saline, dextrose, water, glycerol, ethanol, and combinations thereof. The term specifically excludes cell culture medium. For drugs administered orally, pharmaceutically acceptable carriers include, but are not limited to pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavoring agents, coloring agents and preservatives. Suitable inert diluents include sodium and calcium carbonate, sodium and calcium phosphate, and lactose, while corn starch and alginic acid are suitable disintegrating agents. Binding agents may include starch and gelatin, while the lubricating agent, if present, will generally be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate, to delay absorption in the gastrointestinal tract.
As used herein, a “transformed cell” is a cell into which a vector has been introduced from which a dsRNA molecule may be expressed.
II. DOUBLE-STRANDED RIBONUCLEIC ACID (dsRNA)
As described in more detail herein, the invention provides double-stranded ribonucleic acid (dsRNA) molecules for inhibiting the expression of a GSK-3 gene in a cell or mammal, e.g., in a human having manic depression, or another disorder described herein, where the dsRNA includes an antisense strand having a region of complementarity which is complementary to at least a part of an mRNA formed in the expression of a GSK-3 gene, and where the region of complementarity is less than 30 nucleotides in length, and where said dsRNA, upon contact with a cell expressing a GSK-3 gene, inhibits the expression of a GSK-3 gene, e.g., by at least 30% as assayed by, for example, a PCR or branched DNA (bDNA) based method. The dsRNA of the invention may further include one or more single-stranded nucleotide overhangs.
The dsRNA can be synthesized by standard methods known in the art as further discussed below, e.g., by use of an automated DNA synthesizer, such as are commercially available from, for example, Biosearch, Applied Biosystems, Inc.
The dsRNA includes two RNA strands that are sufficiently complementary to hybridize to form a duplex structure. One strand of the dsRNA (the antisense strand) includes a region of complementarity that is substantially complementary, and generally fully complementary, to a target sequence, derived from the sequence of an mRNA formed during the expression of the GSK-3 gene, the other strand (the sense strand) includes a region that is complementary to the antisense strand, such that the two strands hybridize and form a duplex structure when combined under suitable conditions. Generally, the duplex structure is between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the duplex is 19 base pairs in length. In another embodiment the duplex is 21 base pairs in length. When two different siRNAs are used in combination, the duplex lengths can be identical or can differ.
Similarly, the region of complementarity to the target sequence can be between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the region of complementarity is 19 nucleotides in length. In another embodiment the region of complementarity is 21 nucleotides in length. When two different siRNAs are used in combination, the region of complementarity can be identical or can differ.
Each strand of the dsRNA of invention is generally between 15 and 30, or between 18 and 25, or 18, 19, 20, 21, 22, 23, 24, or 25 nucleotides in length. In other embodiments, each is strand is 25-30 nucleotides in length. Each strand of the duplex can be the same length or of different lengths. When two different siRNAs are used in combination, the lengths of each strand of each siRNA can be identical or can differ.
The dsRNA of the invention can include one or more single-stranded overhang(s) of one or more nucleotides. In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. In another embodiment, the antisense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the sense strand. In further embodiments, the sense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the antisense strand.
A dsRNAs having at least one nucleotide overhang can have unexpectedly superior inhibitory properties than the blunt-ended counterpart. In some embodiments the presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. A dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA can also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs can have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.
In one embodiment, the targeted GSK-3 gene is the human GSK-3 gene. In another embodiment, the targeted GSK-3 gene is a mouse gene. In some embodiments, the sense strand of the dsRNA includes a sense sequence from Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and the antisense sequence includes an antisense sequence of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Alternative antisense agents that target elsewhere in the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be determined using the target sequence and the flanking GSK-3 sequence.
The skilled person is well aware that dsRNAs comprising a duplex structure of between 20 and 23, but specifically 21, base pairs have been hailed as particularly effective in inducing RNA interference (Elbashir et al., EMBO 2001, 20:6877-6888). However, others have found that shorter or longer dsRNAs can be effective as well. In the embodiments described above, by virtue of the nature of the oligonucleotide sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, the dsRNAs of the invention can include at least one strand of a length of minimally 21 nt. It can be reasonably expected that shorter dsRNAs having one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 minus only a few nucleotides on one or both ends may be similarly effective as compared to the dsRNAs described above. Hence, dsRNAs having a partial sequence of at least 15, 16, 17, 18, 19, 20, or more contiguous nucleotides from one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and differing in their ability to inhibit the expression of a GSK-3 gene in an assay as described herein below by not more than 5, 10, 15, 20, 25, or 30% inhibition from a dsRNA comprising the full sequence, are contemplated by the invention. Further dsRNAs that cleave within the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be made using the GSK-3 sequence and the target sequence provided.
In addition, the siRNA agents provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 identify a site in a GSK-3 mRNA that is susceptible to siRNA based cleavage. As such the present invention further features siRNA agents that target within the sequence targeted by one of the agents of the present invention. As used herein a second siRNA agent is said to target within the sequence of a first siRNA agent if the second siRNA agent cleaves the message anywhere within the mRNA that is complementary to the antisense strand of the first siRNA agent. Such a second agent will generally consist of at least 15 contiguous nucleotides from one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 coupled to additional nucleotide sequences taken from the region contiguous to the selected sequence in the GSK-3 gene. For example, the last 15 nucleotides of SEQ ID NO:1 combined with the next 6 nucleotides from the target GSK-3 gene produces a single strand agent of 21 nucleotides that is based on one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The dsRNA of the invention can contain one or more mismatches to the target sequence. In a preferred embodiment, the dsRNA of the invention contains no more than 3 mismatches. If the antisense strand of the dsRNA contains mismatches to a target sequence, it is preferable that the area of mismatch not be located in the center of the region of complementarity. If the antisense strand of the dsRNA contains mismatches to the target sequence, it is preferable that the mismatch be restricted to 5 nucleotides from either end, for example 5, 4, 3, 2, or 1 nucleotide from either the 5′ or 3′ end of the region of complementarity. For example, for a 23 nucleotide dsRNA strand which is complementary to a region of the GSK-3 gene, the dsRNA generally does not contain any mismatch within the central 13 nucleotides. The methods described within the invention can be used to determine whether a dsRNA containing a mismatch to a target sequence is effective in inhibiting the expression of a GSK-3 gene. Consideration of the efficacy of dsRNAs with mismatches in inhibiting expression of a GSK-3 gene is important, especially if the particular region of complementarity in a GSK-3 gene is known to have polymorphic sequence variation within the population.
In some embodiments the sense and/or antisense sequences of the dsRNA molecules featured herein can have the primary sequence shown in the tables with or without the modifications shown in the tables. In other embodiments the dsRNA molecule can differ by not more than 1, 2 or 3 bases from that provided in the tables.
In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. dsRNAs having at least one nucleotide overhang have superior inhibitory properties than their blunt-ended counterparts. The presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA may also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.
Modifications
In yet another embodiment, the dsRNA is chemically modified to enhance stability. The nucleic acids of the invention may be synthesized and/or modified by methods well established in the art, such as those described in “Current protocols in nucleic acid chemistry”, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA, which is hereby incorporated herein by reference. Specific examples of preferred dsRNA compounds useful in this invention include dsRNAs containing modified backbones or no natural internucleoside linkages. As defined in this specification, dsRNAs having modified backbones include those that retain a phosphorus atom in the backbone and those that do not have a phosphorus atom in the backbone. For the purposes of this specification, and as sometimes referenced in the art, modified dsRNAs that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleosides.
Preferred modified dsRNA backbones include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those) having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.
Representative U.S. patents that teach the preparation of the above phosphorus-containing linkages include, but are not limited to, U.S. Pat. Nos. 3,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,195; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,316; 5,550,111; 5,563,253; 5,571,799; 5,587,361; and 5,625,050, each of which is herein incorporated by reference
Preferred modified dsRNA backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatoms and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH2 component parts.
Representative U.S. patents that teach the preparation of the above oligonucleosides include, but are not limited to, U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,64,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623,070; 5,663,312; 5,633,360; 5,677,437; and, 5,677,439, each of which is herein incorporated by reference.
In other preferred dsRNA mimetics, both the sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. One such oligomeric compound, an dsRNA mimetic that has been shown to have excellent hybridization properties, is referred to as a peptide nucleic acid (PNA). In PNA compounds, the sugar backbone of an dsRNA is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. Representative U.S. patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Further teaching of PNA compounds can be found in Nielsen et al., Science, 1991, 254, 1497-1500.
Most preferred embodiments of the invention are dsRNAs with phosphorothioate backbones and oligonucleosides with heteroatom backbones, and in particular —CH2—NH—CH2—, —CH2—N(CH3)—O—CH2—[known as a methylene (methylimino) or MMI backbone], —CH2—O—N(CH3)—CH2—, —CH2—N(CH3)—N(CH3)—CH2— and —N(CH3)—CH2—CH2— [wherein the native phosphodiester backbone is represented as —O—P—O—CH2—] of the above-referenced U.S. Pat. No. 5,489,677, and the amide backbones of the above-referenced U.S. Pat. No. 5,602,240. Also preferred are dsRNAs having morpholino backbone structures of the above-referenced U.S. Pat. No. 5,034,506.
Modified dsRNAs may also contain one or more substituted sugar moieties. Preferred dsRNAs comprise one of the following at the 2′ position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; O-, S- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C1 to C10 alkyl or C2 to C10 alkenyl and alkynyl. Particularly preferred are O[(CH2)nO]mCH3, O(CH2)nOCH3, O(CH2)nNH2, O(CH2)nCH3, O(CH2)nONH2, and O(CH2)2ON[(CH2)nCH3)]2, where n and m are from 1 to about 10. Other preferred dsRNAs comprise one of the following at the 2′ position: C1 to C10 lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH3, OCN, Cl, Br, CN, CF3, OCF3, SOCH3, SO2CH3, ONO2, NO2, N3, NH2, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an dsRNA, or a group for improving the pharmacodynamic properties of an dsRNA, and other substituents having similar properties. A preferred modification includes 2′-methoxyethoxy (2′-O—CH2CH2OCH3, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) (Martin et al., Helv. Chim. Acta, 1995, 78, 486-504) i.e., an alkoxy-alkoxy group. A further preferred modification includes 2′-dimethylaminooxyethoxy, i.e., a O(CH2)2ON(CH3)2 group, also known as 2′-DMAOE, as described in examples herein below, and 2′-dimethylaminoethoxyethoxy (also known in the art as 2′-O-dimethylaminoethoxyethyl or 2′-DMAEOE), i.e., 2′-O—CH2—O—CH2—N(CH2)2, also described in examples herein below.
Other preferred modifications include 2′-methoxy (2′-OCH3), 2′-aminopropoxy (2′-OCH2CH2CH2NH2) and 2′-fluoro (2′-F). Similar modifications may also be made at other positions on the dsRNA, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked dsRNAs and the 5′ position of 5′ terminal nucleotide. DsRNAs may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar. Representative U.S. patents that teach the preparation of such modified sugar structures include, but are not limited to, U.S. Pat. Nos. 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878; 5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427; 5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265; 5,658,873; 5,670,633; and 5,700,920, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference in its entirety.
DsRNAs may also include nucleobase (often referred to in the art simply as “base”) modifications or substitutions. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl anal other 8-substituted adenines and guanines, 5-halo, particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-daazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science And Engineering, pages 858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, these disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y S., Chapter 15, DsRNA Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B., Ed., CRC Press, 1993. Certain of these nucleobases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and 0-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. (Sanghvi, Y. S., Crooke, S. T. and Lebleu, B., Eds., DsRNA Research and Applications, CRC Press, Boca Raton, 1993, pp. 276-278) and are presently preferred base substitutions, even more particularly when combined with 2′-O-methoxyethyl sugar modifications.
Representative U.S. patents that teach the preparation of certain of the above noted modified nucleobases as well as other modified nucleobases include, but are not limited to, the above noted U.S. Pat. No. 3,687,808, as well as U.S. Pat. Nos. 4,845,205; 5,130,30; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187; 5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469; 5,594,121, 5,596,091; 5,614,617; and 5,681,941, each of which is herein incorporated by reference, and U.S. Pat. No. 5,750,692, also herein incorporated by reference.
Conjugates
Another modification of the dsRNAs of the invention involves chemically linking to the dsRNA one or more moieties or conjugates which enhance the activity, cellular distribution or cellular uptake of the dsRNA. Such moieties include but are not limited to lipid moieties such as a cholesterol moiety (Letsinger et al., Proc. Natl. Acid. Sci. USA, 199, 86, 6553-6556), cholic acid (Manoharan et al., Biorg. Med. Chem. Let., 1994 4 1053-1060), a thioether, e.g., beryl-S-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Biorg. Med. Chem. Let., 1993, 3, 2765-2770), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J, 1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethyl-ammonium 1,2-di-O-hexadecyl-rac-glycero-3-Hphosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237), or an octadecylamine or hexylamino-carbonyloxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937).
Representative U.S. patents that teach the preparation of such dsRNA conjugates include, but are not limited to, U.S. Pat. Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, each of which is herein incorporated by reference.
It is not necessary for all positions in a given compound to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single compound or even at a single nucleoside within an dsRNA. The present invention also includes dsRNA compounds which are chimeric compounds. “Chimeric” dsRNA compounds or “chimeras,” in the context of this invention, are dsRNA compounds, particularly dsRNAs, which contain two or more chemically distinct regions, each made up of at least one monomer unit, i.e., a nucleotide in the case of an dsRNA compound. These dsRNAs typically contain at least one region wherein the dsRNA is modified so as to confer upon the dsRNA increased resistance to nuclease degradation, increased cellular uptake, and/or increased binding affinity for the target nucleic acid. An additional region of the dsRNA may serve as a substrate for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. By way of example, RNase H is a cellular endonuclease which cleaves the RNA strand of an RNA:DNAduplex. Activation of RNase H, therefore, results in cleavage of the RNA target, thereby greatly enhancing the efficiency of dsRNA inhibition of gene expression. Consequently, comparable results can often be obtained with shorter dsRNAs when chimeric dsRNAs are used, compared to phosphorothioate deoxy dsRNAs hybridizing to the same target region. Cleavage of the RNA target can be routinely detected by gel electrophoresis and, if necessary, associated nucleic acid hybridization techniques known in the art.
In certain instances, the dsRNA may be modified by a non-ligand group. A number of non-ligand molecules have been conjugated to dsRNAs in order to enhance the activity, cellular distribution or cellular uptake of the dsRNA, and procedures for performing such conjugations are available in the scientific literature. Such non-ligand moieties have included lipid moieties, such as cholesterol (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86:6553), cholic acid (Manoharan et al., Bioorg. Med. Chem. Lett., 1994, 4:1053), a thioether, e.g., hexyl-5-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660:306; Manoharan et al., Bioorg. Med. Chem. Let., 1993, 3:2765), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20:533), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J., 1991, 10:111; Kabanov et al., FEBS Lett., 1990, 259:327; Svinarchuk et al., Biochimie, 1993, 75:49), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36:3651; Shea et al., Nucl. Acids Res., 1990, 18:3777), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14:969), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36:3651), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264:229), or an octadecylamine or hexylamino-carbonyl-oxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277:923). Representative United States patents that teach the preparation of such dsRNA conjugates have been listed above. Typical conjugation protocols involve the synthesis of dsRNAs bearing an aminolinker at one or more positions of the sequence. The amino group is then reacted with the molecule being conjugated using appropriate coupling or activating reagents. The conjugation reaction may be performed either with the dsRNA still bound to the solid support or following cleavage of the dsRNA in solution phase. Purification of the dsRNA conjugate by HPLC typically affords the pure conjugate.
Vector Encoded siRNA Agents
In another aspect of the invention, GSK-3 specific dsRNA molecules that are expressed from transcription units inserted into DNA or RNA vectors (see, e.g., Couture, A, et al., TIG. (1996), 12:5-10; Skillern, A., et al., International PCT Publication No. WO 00/22113, Conrad, International PCT Publication No. WO 00/22114, and Conrad, U.S. Pat. No. 6,054,299). These transgenes can be introduced as a linear construct, a circular plasmid, or a viral vector, which can be incorporated and inherited as a transgene integrated into the host genome. The transgene can also be constructed to permit it to be inherited as an extrachromosomal plasmid (Gassmann, et al., Proc. Natl. Acad. Sci. USA (1995) 92:1292).
The individual strands of a dsRNA can be transcribed by promoters on two separate expression vectors and co-transfected into a target cell. Alternatively each individual strand of the dsRNA can be transcribed by promoters both of which are located on the same expression plasmid. In a preferred embodiment, a dsRNA is expressed as an inverted repeat joined by a linker polynucleotide sequence such that the dsRNA has a stem and loop structure.
The recombinant dsRNA expression vectors are generally DNA plasmids or viral vectors. dsRNA expressing viral vectors can be constructed based on, but not limited to, adeno-associated virus (for a review, see Muzyczka, et al., Curr. Topics Micro. Immunol. (1992) 158:97-129)); adenovirus (see, for example, Berkner, et al., BioTechniques (1998) 6:616), Rosenfeld et al. (1991, Science 252:431-434), and Rosenfeld et al. (1992), Cell 68:143-155)); or alphavirus as well as others known in the art. Retroviruses have been used to introduce a variety of genes into many different cell types, including epithelial cells, in vitro and/or in vivo (see, e.g., Eglitis, et al., Science (1985) 230:1395-1398; Danos and Mulligan, Proc. Natl. Acad. Sci. USA (1998) 85:6460-6464; Wilson et al., 1988, Proc. Natl. Acad. Sci. USA 85:3014-3018; Armentano et al., 1990, Proc. Natl. Acad. Sci. USA 87:61416145; Huber et al., 1991, Proc. Natl. Acad. Sci. USA 88:8039-8043; Ferry et al., 1991, Proc. Natl. Acad. Sci. USA 88:8377-8381; Chowdhury et al., 1991, Science 254:1802-1805; van Beusechem. et al., 1992, Proc. Nad. Acad. Sci. USA 89:7640-19; Kay et al., 1992, Human Gene Therapy 3:641-647; Dai et al., 1992, Proc. Natl. Acad. Sci. USA 89:10892-10895; Hwu et al., 1993, J. Immunol. 150:4104-4115; U.S. Pat. No. 4,868,116; U.S. Pat. No. 4,980,286; PCT Application WO 89/07136; PCT Application WO 89/02468; PCT Application WO 89/05345; and PCT Application WO 92/07573). Recombinant retroviral vectors capable of transducing and expressing genes inserted into the genome of a cell can be produced by transfecting the recombinant retroviral genome into suitable packaging cell lines such as PA317 and Psi-CRIP (Comette et al., 1991, Human Gene Therapy 2:5-10; Cone et al., 1984, Proc. Natl. Acad. Sci. USA 81:6349). Recombinant adenoviral vectors can be used to infect a wide variety of cells and tissues in susceptible hosts (e.g., rat, hamster, dog, and chimpanzee) (Hsu et al., 1992, J. Infectious Disease, 166:769), and also have the advantage of not requiring mitotically active cells for infection.
Any viral vector capable of accepting the coding sequences for the dsRNA molecule(s) to be expressed can be used, for example vectors derived from adenovirus (AV); adeno-associated virus (AAV); retroviruses (e.g., lentiviruses (LV), Rhabdoviruses, murine leukemia virus); herpes virus, and the like. The tropism of viral vectors can be modified by pseudotyping the vectors with envelope proteins or other surface antigens from other viruses, or by substituting different viral capsid proteins, as appropriate.
For example, lentiviral vectors of the invention can be pseudotyped with surface proteins from vesicular stomatitis virus (VSV), rabies, Ebola, Mokola, and the like. AAV vectors of the invention can be made to target different cells by engineering the vectors to express different capsid protein serotypes. For example, an AAV vector expressing a serotype 2 capsid on a serotype 2 genome is called AAV 2/2. This serotype 2 capsid gene in the AAV 2/2 vector can be replaced by a serotype 5 capsid gene to produce an AAV 2/5 vector. Techniques for constructing AAV vectors which express different capsid protein serotypes are within the skill in the art; see, e.g., Rabinowitz J E et al. (2002), J Virol 76:791-801, the entire disclosure of which is herein incorporated by reference.
Selection of recombinant viral vectors suitable for use in the invention, methods for inserting nucleic acid sequences for expressing the dsRNA into the vector, and methods of delivering the viral vector to the cells of interest are within the skill in the art. See, for example, Dornburg R (1995), Gene Therap. 2: 301-310; Eglitis M A (1988), Biotechniques 6: 608-614; Miller A D (1990), Hum Gene Therap. 1: 5-14; Anderson W F (1998), Nature 392: 25-30; and Rubinson D A et al., Nat. Genet. 33: 401-406, the entire disclosures of which are herein incorporated by reference.
Preferred viral vectors are those derived from AV and AAV. In a particularly preferred embodiment, the dsRNA of the invention is expressed as two separate, complementary single-stranded RNA molecules from a recombinant AAV vector having, for example, either the U6 or H1 RNA promoters, or the cytomegalovirus (CMV) promoter.
A suitable AV vector for expressing the dsRNA of the invention, a method for constructing the recombinant AV vector, and a method for delivering the vector into target cells, are described in Xia H et al. (2002), Nat. Biotech. 20: 1006-1010.
Suitable AAV vectors for expressing the dsRNA of the invention, methods for constructing the recombinant AV vector, and methods for delivering the vectors into target cells are described in Samulski R et al. (1987), J. Virol. 61: 3096-3101; Fisher K J et al. (1996), J. Virol, 70: 520-532; Samulski R et al. (1989), J. Virol. 63: 3822-3826; U.S. Pat. No. 5,252,479; U.S. Pat. No. 5,139,941; International Patent Application No. WO 94/13788; and International Patent Application No. WO 93/24641, the entire disclosures of which are herein incorporated by reference.
The promoter driving dsRNA expression in either a DNA plasmid or viral vector of the invention may be a eukaryotic RNA polymerase I (e.g. ribosomal RNA promoter), RNA polymerase II (e.g. CMV early promoter or actin promoter or U1 snRNA promoter) or generally RNA polymerase III promoter (e.g. U6 snRNA or 7SK RNA promoter) or a prokaryotic promoter, for example the T7 promoter, provided the expression plasmid also encodes T7 RNA polymerase required for transcription from a T7 promoter. The promoter can also direct transgene expression to the pancreas (see, e.g., the insulin regulatory sequence for pancreas (Bucchini et al., 1986, Proc. Natl. Acad. Sci. USA 83:2511-2515)).
In addition, expression of the transgene can be precisely regulated, for example, by using an inducible regulatory sequence and expression systems such as a regulatory sequence that is sensitive to certain physiological regulators, e.g., circulating glucose levels, or hormones (Docherty et al., 1994, FASEB J. 8:20-24). Such inducible expression systems, suitable for the control of transgene expression in cells or in mammals include regulation by ecdysone, by estrogen, progesterone, tetracycline, chemical inducers of dimerization, and isopropyl-beta-D1-thiogalactopyranoside (EPTG). A person skilled in the art would be able to choose the appropriate regulatory/promoter sequence based on the intended use of the dsRNA transgene.
Generally, recombinant vectors capable of expressing dsRNA molecules are delivered as described below, and persist in target cells. Alternatively, viral vectors can be used that provide for transient expression of dsRNA molecules. Such vectors can be repeatedly administered as necessary. Once expressed, the dsRNAs bind to target RNA and modulate its function or expression. Delivery of dsRNA expressing vectors can be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that allows for introduction into a desired target cell.
dsRNA expression DNA plasmids are typically transfected into target cells as a complex with cationic lipid carriers (e.g. Oligofectamine) or non-cationic lipid-based carriers (e.g. Transit-TKOTM). Multiple lipid transfections for dsRNA-mediated knockdowns targeting different regions of a single GSK-3 gene or two GSK-3 genes over a period of a week or more are also contemplated by the invention. Successful introduction of the vectors of the invention into host cells can be monitored using various known methods. For example, transient transfection. can be signaled with a reporter, such as a fluorescent marker, such as Green Fluorescent Protein (GFP). Stable transfection of ex vivo cells can be ensured using markers that provide the transfected cell with resistance to specific environmental factors (e.g., antibiotics and drugs), such as hygromycin B resistance.
The GSK-3 specific dsRNA molecules can also be inserted into vectors and used as gene therapy vectors for human patients. Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or by stereotactic injection (see e.g., Chen et al. (1994) Proc. Natl. Acad. Sci. USA 91:3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can include a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells which produce the gene delivery system.
III. PHARMACEUTICAL COMPOSITIONS COMPRISING dsRNA
In one embodiment, the invention provides pharmaceutical compositions comprising a dsRNA, as described herein, and a pharmaceutically acceptable carrier. The pharmaceutical composition comprising the dsRNA is useful for treating a disease or disorder associated with the expression or activity of a GSK-3 gene, such as pathological processes mediated by GSK-3 expression. Such pharmaceutical compositions are formulated based on the mode of delivery. One example is compositions that are formulated for systemic administration via parenteral delivery.
The pharmaceutical compositions featured herein are administered in dosages sufficient to inhibit expression of a GSK-3 gene. In general, a suitable dose of dsRNA will be in the range of 0.01 to 200.0 milligrams per kilogram body weight of the recipient per day, generally in the range of 1 to 50 mg per kilogram body weight per day. For example, the dsRNA can be administered at 0.01 mg/kg, 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg, 5.0 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, or 50 mg/kg per single dose.
The pharmaceutical composition may be administered once daily or the dsRNA may be administered as two, three, or more sub-doses at appropriate intervals throughout the day or even using continuous infusion or delivery through a controlled release formulation. In that case, the dsRNA contained in each sub-dose must be correspondingly smaller in order to achieve the total daily dosage. The dosage unit can also be compounded for delivery over several days, e.g., using a conventional sustained release formulation which provides sustained release of the dsRNA over a several day period. Sustained release formulations are well known in the art and are particularly useful for delivery of agents at a particular site, such as could be used with the agents of the present invention. In this embodiment, the dosage unit contains a corresponding multiple of the daily dose.
The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a composition can include a single treatment or a series of treatments. Estimates of effective dosages and in vivo half-lives for the individual dsRNAs encompassed by the invention can be made using conventional methodologies or on the basis of in vivo testing using an appropriate animal model, as described elsewhere herein.
Advances in mouse genetics have generated a number of mouse models for the study of various human diseases, such as pathological processes mediated by GSK-3 expression. Such models are used for in vivo testing of dsRNA, as well as for determining a therapeutically effective dose.
The data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of compositions featured in the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the methods featured in the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.
The dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by target gene expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.
Administration
The present invention also includes pharmaceutical compositions and formulations which include the dsRNA compounds of the invention. The pharmaceutical compositions of the present invention may be administered in a number of ways depending upon whether local or systemic treatment is desired and upon the area to be treated. Administration may be topical, pulmonary, e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal, intranasal, epidermal and transdermal), oral or parenteral. Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration. In one embodiment, the pharmaceutical composition is administered intracranially, directly into the nucleus accumbens.
Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders. Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable. Coated condoms, gloves and the like may also be useful. Preferred topical formulations include those in which the dsRNAs of the invention are in admixture with a topical delivery agent such as lipids, liposomes, fatty acids, fatty acid esters, steroids, chelating agents and surfactants. Preferred lipids and liposomes include neutral (e.g. dioleoylphosphatidyl DOPE ethanolamine, dimyristoylphosphatidyl choline DMPC, distearolyphosphatidyl choline) negative (e.g. dimyristoylphosphatidyl glycerol DMPG) and cationic (e.g. dioleoyltetramethylaminopropyl DOTAP and dioleoylphosphatidyl ethanolamine DOTMA). DsRNAs of the invention may be encapsulated within liposomes or may form complexes thereto, in particular to cationic liposomes. Alternatively, dsRNAs may be complexed to lipids, in particular to cationic lipids. Preferred fatty acids and esters include but are not limited arachidonic acid, oleic acid, eicosanoic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a C1-10 alkyl ester (e.g. isopropylmyristate IPM), monoglyceride, diglyceride or pharmaceutically acceptable salt thereof. Topical formulations are described in detail in U.S. patent application Ser. No. 09/315,298 filed on May 20, 1999 which is incorporated herein by reference in its entirety.
Compositions and formulations for oral administration include powders or granules, microparticulates, nanoparticulates, suspensions or solutions in water or non-aqueous media, capsules, gel capsules, sachets, tablets or minitablets. Thickeners, flavoring agents, diluents, emulsifiers, dispersing aids or binders may be desirable. Preferred oral formulations are those in which dsRNAs of the invention are administered in conjunction with one or more penetration enhancers surfactants and chelators. Preferred surfactants include fatty acids and/or esters or salts thereof, bile acids and/or salts thereof. Preferred bile acids/salts include chenodeoxycholic acid (CDCA) and ursodeoxychenodeoxycholic acid (UDCA), cholic acid, dehydrocholic acid, deoxycholic acid, glucholic acid, glycholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium tauro-24,25-dihydro-fusidate and sodium glycodihydrofusidate. Preferred fatty acids include arachidonic acid, undecanoic acid, oleic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a monoglyceride, a diglyceride or a pharmaceutically acceptable salt thereof (e.g. sodium). Also preferred are combinations of penetration enhancers, for example, fatty acids/salts in combination with bile acids/salts. A particularly preferred combination is the sodium salt of lauric acid, capric acid and UDCA. Further penetration enhancers include polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether. DsRNAs of the invention may be delivered orally, in granular form including sprayed dried particles, or complexed to form micro or nanoparticles. DsRNA complexing agents include poly-amino acids; polyimines; polyacrylates; polyalkylacrylates, polyoxethanes, polyalkylcyanoacrylates; cationized gelatins, albumins, starches, acrylates, polyethyleneglycols (PEG) and starches; polyalkylcyanoacrylates; DEAE-derivatized polyimines, pollulans, celluloses and starches. Particularly preferred complexing agents include chitosan, N-trimethylchitosan, poly-L-lysine, polyhistidine, polyornithine, polyspermines, protamine, polyvinylpyridine, polythiodiethylaminomethylethylene P(TDAE), polyaminostyrene (e.g. p-amino), poly(methylcyanoacrylate), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly(isobutylcyanoacrylate), poly(isohexylcynaoacrylate), DEAE-methacrylate, DEAE-hexylacrylate, DEAE-acrylamide, DEAE-albumin and DEAE-dextran, polymethylacrylate, polyhexylacrylate, poly(D,L-lactic acid), poly(DL-lactic-co-glycolic acid (PLGA), alginate, and polyethyleneglycol (PEG). Oral formulations for dsRNAs and their preparation are described in detail in U.S. application. Ser. No. 08/886,829 (filed Jul. 1, 1997), Ser. No. 09/108,673 (filed Jul. 1, 1998), Ser. No. 09/256,515 (filed Feb. 23, 1999), Ser. No. 09/082,624 (filed May 21, 1998) and Ser. No. 09/315,298 (filed May 20, 1999), each of which is incorporated herein by reference in their entirety.
Compositions and formulations for parenteral, intrathecal, intraventricular or intrahepatic administration may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives such as, but not limited to, penetration enhancers, carrier compounds and other pharmaceutically acceptable carriers or excipients.
Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, and liposome-containing formulations. These compositions may be generated from a variety of components that include, but are not limited to, preformed liquids, self-emulsifying solids and self-emulsifying semisolids. Particularly preferred are formulations that target the liver when treating hepatic disorders such as hepatic carcinoma.
The pharmaceutical formulations of the present invention, which may conveniently be presented in unit dosage form, may be prepared according to conventional techniques well known in the pharmaceutical industry. Such techniques include the step of bringing into association the active ingredients with the pharmaceutical carrier(s) or excipient(s). In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredients with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.
The compositions of the present invention may be formulated into any of many possible dosage forms such as, but not limited to, tablets, capsules, gel capsules, liquid syrups, soft gels, suppositories, and enemas. The compositions of the present invention may also be formulated as suspensions in aqueous, non-aqueous or mixed media. Aqueous suspensions may further contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.
Emulsions
The compositions of the present invention may be prepared and formulated as emulsions. Emulsions are typically heterogenous systems of one liquid dispersed in another in the form of droplets usually exceeding 0.1 μm in diameter (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199; Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., Volume 1, p. 245; Block in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 2, p. 335; Higuchi et al., in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 301). Emulsions are often biphasic systems comprising two immiscible liquid phases intimately mixed and dispersed with each other. In general, emulsions may be of either the water-in-oil (w/o) or the oil-in-water (o/w) variety. When an aqueous phase is finely divided into and dispersed as minute droplets into a bulk oily phase, the resulting composition is called a water-in-oil (w/o) emulsion. Alternatively, when an oily phase is finely divided into and dispersed as minute droplets into a bulk aqueous phase, the resulting composition is called an oil-in-water (o/w) emulsion. Emulsions may contain additional components in addition to the dispersed phases, and the active drug which may be present as a solution in either the aqueous phase, oily phase or itself as a separate phase. Pharmaceutical excipients such as emulsifiers, stabilizers, dyes, and anti-oxidants may also be present in emulsions as needed. Pharmaceutical emulsions may also be multiple emulsions that are comprised of more than two phases such as, for example, in the case of oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w) emulsions. Such complex formulations often provide certain advantages that simple binary emulsions do not. Multiple emulsions in which individual oil droplets of an o/w emulsion enclose small water droplets constitute a w/o/w emulsion. Likewise a system of oil droplets enclosed in globules of water stabilized in an oily continuous phase provides an o/w/o emulsion.
Emulsions are characterized by little or no thermodynamic stability. Often, the dispersed or discontinuous phase of the emulsion is well dispersed into the external or continuous phase and maintained in this form through the means of emulsifiers or the viscosity of the formulation. Either of the phases of the emulsion may be a semisolid or a solid, as is the case of emulsion-style ointment bases and creams. Other means of stabilizing emulsions entail the use of emulsifiers that may be incorporated into either phase of the emulsion. Emulsifiers may broadly be classified into four categories: synthetic surfactants, naturally occurring emulsifiers, absorption bases, and finely dispersed solids (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).
Synthetic surfactants, also known as surface active agents, have found wide applicability in the formulation of emulsions and have been reviewed in the literature (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), Marcel Dekker, Inc., New York, N.Y., 1988, volume 1, p. 199). Surfactants are typically amphiphilic and comprise a hydrophilic and a hydrophobic portion. The ratio of the hydrophilic to the hydrophobic nature of the surfactant has been termed the hydrophile/lipophile balance (HLB) and is a valuable tool in categorizing and selecting surfactants in the preparation of formulations. Surfactants may be classified into different classes based on the nature of the hydrophilic group: nonionic, anionic, cationic and amphoteric (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285).
Naturally occurring emulsifiers used in emulsion formulations include lanolin, beeswax, phosphatides, lecithin and acacia. Absorption bases possess hydrophilic properties such that they can soak up water to form w/o emulsions yet retain their semisolid consistencies, such as anhydrous lanolin and hydrophilic petrolatum. Finely divided solids have also been used as good emulsifiers especially in combination with surfactants and in viscous preparations. These include polar inorganic solids, such as heavy metal hydroxides, nonswelling clays such as bentonite, attapulgite, hectorite, kaolin, montmorillonite, colloidal aluminum silicate and colloidal magnesium aluminum silicate, pigments and nonpolar solids such as carbon or glyceryl tristearate.
A large variety of non-emulsifying materials are also included in emulsion formulations and contribute to the properties of emulsions. These include fats, oils, waxes, fatty acids, fatty alcohols, fatty esters, humectants, hydrophilic colloids, preservatives and antioxidants (Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).
Hydrophilic colloids or hydrocolloids include naturally occurring gums and synthetic polymers such as polysaccharides (for example, acacia, agar, alginic acid, carrageenan, guar gum, karaya gum, and tragacanth), cellulose derivatives (for example, carboxymethylcellulose and carboxypropylcellulose), and synthetic polymers (for example, carbomers, cellulose ethers, and carboxyvinyl polymers). These disperse or swell in water to form colloidal solutions that stabilize emulsions by forming strong interfacial films around the dispersed-phase droplets and by increasing the viscosity of the external phase.
Since emulsions often contain a number of ingredients such as carbohydrates, proteins, sterols and phosphatides that may readily support the growth of microbes, these formulations often incorporate preservatives. Commonly used preservatives included in emulsion formulations include methyl paraben, propyl paraben, quaternary ammonium salts, benzalkonium chloride, esters of p-hydroxybenzoic acid, and boric acid. Antioxidants are also commonly added to emulsion formulations to prevent deterioration of the formulation. Antioxidants used may be free radical scavengers such as tocopherols, alkyl gallates, butylated hydroxyanisole, butylated hydroxytoluene, or reducing agents such as ascorbic acid and sodium metabisulfite, and antioxidant synergists such as citric acid, tartaric acid, and lecithin.
The application of emulsion formulations via dermatological, oral and parenteral routes and methods for their manufacture have been reviewed in the literature (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Emulsion formulations for oral delivery have been very widely used because of ease of formulation, as well as efficacy from an absorption and bioavailability standpoint (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Mineral-oil base laxatives, oil-soluble vitamins and high fat nutritive preparations are among the materials that have commonly been administered orally as o/w emulsions.
In one embodiment of the present invention, the compositions of dsRNAs and nucleic acids are formulated as microemulsions. A microemulsion may be defined as a system of water, oil and amphiphile which is a single optically isotropic and thermodynamically stable liquid solution (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Typically microemulsions are systems that are prepared by first dispersing an oil in an aqueous surfactant solution and then adding a sufficient amount of a fourth component, generally an intermediate chain-length alcohol to form a transparent system. Therefore, microemulsions have also been described as thermodynamically stable, isotropically clear dispersions of two immiscible liquids that are stabilized by interfacial films of surface-active molecules (Leung and Shah, in: Controlled Release of Drugs: Polymers and Aggregate Systems, Rosoff, M., Ed., 1989, VCH Publishers, New York, pages 185-215). Microemulsions commonly are prepared via a combination of three to five components that include oil, water, surfactant, cosurfactant and electrolyte. Whether the microemulsion is of the water-in-oil (w/o) or an oil-in-water (o/w) type is dependent on the properties of the oil and surfactant used and on the structure and geometric packing of the polar heads and hydrocarbon tails of the surfactant molecules (Schott, in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 271).
The phenomenological approach utilizing phase diagrams has been extensively studied and has yielded a comprehensive knowledge, to one skilled in the art, of how to formulate microemulsions (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335). Compared to conventional emulsions, microemulsions offer the advantage of solubilizing water-insoluble drugs in a formulation of thermodynamically stable droplets that are formed spontaneously.
Surfactants used in the preparation of microemulsions include, but are not limited to, ionic surfactants, non-ionic surfactants, Brij 96, polyoxyethylene oleyl ethers, polyglycerol fatty acid esters, tetraglycerol monolaurate (ML310), tetraglycerol monooleate (MO310), hexaglycerol monooleate (PO310), hexaglycerol pentaoleate (PO500), decaglycerol monocaprate (MCA750), decaglycerol monooleate (MO750), decaglycerol sequioleate (SO750), decaglycerol decaoleate (DAO750), alone or in combination with cosurfactants. The cosurfactant, usually a short-chain alcohol such as ethanol, 1-propanol, and 1-butanol, serves to increase the interfacial fluidity by penetrating into the surfactant film and consequently creating a disordered film because of the void space generated among surfactant molecules. Microemulsions may, however, be prepared without the use of cosurfactants and alcohol-free self-emulsifying microemulsion systems are known in the art. The aqueous phase may typically be, but is not limited to, water, an aqueous solution of the drug, glycerol, PEG300, PEG400, polyglycerols, propylene glycols, and derivatives of ethylene glycol. The oil phase may include, but is not limited to, materials such as Captex 300, Captex 355, Capmul MCM, fatty acid esters, medium chain (C8-C12) mono, di, and tri-glycerides, polyoxyethylated glyceryl fatty acid esters, fatty alcohols, polyglycolized glycerides, saturated polyglycolized C8-C10 glycerides, vegetable oils and silicone oil.
Microemulsions are particularly of interest from the standpoint of drug solubilization and the enhanced absorption of drugs. Lipid based microemulsions (both o/w and w/o) have been proposed to enhance the oral bioavailability of drugs, including peptides (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385-1390; Ritschel, Meth. Find. Exp. Clin. Pharmacol., 1993, 13, 205). Microemulsions afford advantages of improved drug solubilization, protection of drug from enzymatic hydrolysis, possible enhancement of drug absorption due to surfactant-induced alterations in membrane fluidity and permeability, ease of preparation, ease of oral administration over solid dosage forms, improved clinical potency, and decreased toxicity (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385; Ho et al., J. Pharm. Sci., 1996, 85, 138-143). Often microemulsions may form spontaneously when their components are brought together at ambient temperature. This may be particularly advantageous when formulating thermolabile drugs, peptides or dsRNAs. Microemulsions have also been effective in the transdermal delivery of active components in both cosmetic and pharmaceutical applications. It is expected that the microemulsion compositions and formulations of the present invention will facilitate the increased systemic absorption of dsRNAs and nucleic acids from the gastrointestinal tract, as well as improve the local cellular uptake of dsRNAs and nucleic acids.
Microemulsions of the present invention may also contain additional components and additives such as sorbitan monostearate (Grill 3), Labrasol, and penetration enhancers to improve the properties of the formulation and to enhance the absorption of the dsRNAs and nucleic acids of the present invention. Penetration enhancers used in the microemulsions of the present invention may be classified as belonging to one of five broad categories—surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of these classes has been discussed above.
Liposomal Formulations
There are many organized surfactant structures besides microemulsions that have been studied and used for the formulation of drugs. These include monolayers, micelles, bilayers and vesicles. Vesicles, such as liposomes, have attracted great interest because of their specificity and the duration of action they offer from the standpoint of drug delivery. As used in the present invention, the term “liposome” means a vesicle composed of amphiphilic lipids arranged in a spherical bilayer or bilayers.
Liposomes are unilamellar or multilamellar vesicles which have a membrane formed from a lipophilic material and an aqueous interior. The aqueous portion contains the composition to be delivered. Cationic liposomes possess the advantage of being able to fuse to the cell wall. Non-cationic liposomes, although not able to fuse as efficiently with the cell wall, are taken up by macrophages in vivo.
In order to cross intact mammalian skin, lipid vesicles must pass through a series of fine pores, each with a diameter less than 50 nm, under the influence of a suitable transdermal gradient. Therefore, it is desirable to use a liposome which is highly deformable and able to pass through such fine pores.
Further advantages of liposomes include; liposomes obtained from natural phospholipids are biocompatible and biodegradable; liposomes can incorporate a wide range of water and lipid soluble drugs; liposomes can protect encapsulated drugs in their internal compartments from metabolism and degradation (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Important considerations in the preparation of liposome formulations are the lipid surface charge, vesicle size and the aqueous volume of the liposomes.
Liposomes are useful for the transfer and delivery of active ingredients to the site of action. Because the liposomal membrane is structurally similar to biological membranes, when liposomes are applied to a tissue, the liposomes start to merge with the cellular membranes and as the merging of the liposome and cell progresses, the liposomal contents are emptied into the cell where the active agent may act.
Liposomal formulations have been the focus of extensive investigation as the mode of delivery for many drugs. There is growing evidence that for topical administration, liposomes present several advantages over other formulations. Such advantages include reduced side-effects related to high systemic absorption of the administered drug, increased accumulation of the administered drug at the desired target, and the ability to administer a wide variety of drugs, both hydrophilic and hydrophobic, into the skin.
Several reports have detailed the ability of liposomes to deliver agents including high-molecular weight DNA into the skin. Compounds including analgesics, antibodies, hormones and high-molecular weight DNAs have been administered to the skin. The majority of applications resulted in the targeting of the upper epidermis
Liposomes fall into two broad classes. Cationic liposomes are positively charged liposomes which interact with the negatively charged DNA molecules to form a stable complex. The positively charged DNA/liposome complex binds to the negatively charged cell surface and is internalized in an endosome. Due to the acidic pH within the endosome, the liposomes are ruptured, releasing their contents into the cell cytoplasm (Wang et al., Biochem. Biophys. Res. Commun, 1987, 147, 980-985).
Liposomes which are pH-sensitive or negatively-charged, entrap DNA rather than complex with it. Since both the DNA and the lipid are similarly charged, repulsion rather than complex formation occurs. Nevertheless, some DNA is entrapped within the aqueous interior of these liposomes. pH-sensitive liposomes have been used to deliver DNA encoding the thymidine kinase gene to cell monolayers in culture. Expression of the exogenous gene was detected in the target cells (Zhou et al., Journal of Controlled Release, 1992, 19, 269-274).
One major type of liposomal composition includes phospholipids other than naturally-derived phosphatidylcholine. Neutral liposome compositions, for example, can be formed from dimyristoyl phosphatidylcholine (DMPC) or dipalmitoyl phosphatidylcholine (DPPC). Anionic liposome compositions generally are formed from dimyristoyl phosphatidylglycerol, while anionic fusogenic liposomes are formed primarily from dioleoyl phosphatidylethanolamine (DOPE). Another type of liposomal composition is formed from phosphatidylcholine (PC) such as, for example, soybean PC, and egg PC. Another type is formed from mixtures of phospholipid and/or phosphatidylcholine and/or cholesterol.
Several studies have assessed the topical delivery of liposomal drug formulations to the skin. Application of liposomes containing interferon to guinea pig skin resulted in a reduction of skin herpes sores while delivery of interferon via other means (e.g., as a solution or as an emulsion) were ineffective (Weiner et al., Journal of Drug Targeting, 1992, 2, 405-410). Further, an additional study tested the efficacy of interferon administered as part of a liposomal formulation to the administration of interferon using an aqueous system, and concluded that the liposomal formulation was superior to aqueous administration (du Plessis et al., Antiviral Research, 1992, 18, 259-265).
Non-ionic liposomal systems have also been examined to determine their utility in the delivery of drugs to the skin, in particular systems comprising non-ionic surfactant and cholesterol. Non-ionic liposomal formulations comprising NovasomeTM I (glyceryl dilaurate/cholesterol/polyoxyethylene-10-stearyl ether) and NovasomeTM II (glyceryl distearate/cholesterol/polyoxyethylene-10-stearyl ether) were used to deliver cyclosporin-A into the dermis of mouse skin. Results indicated that such non-ionic liposomal systems were effective in facilitating the deposition of cyclosporin-A into different layers of the skin (Hu et al. S.T.P.Pharma. Sci., 1994, 4, 6, 466).
Liposomes also include “sterically stabilized” liposomes, a term which, as used herein, refers to liposomes comprising one or more specialized lipids that, when incorporated into liposomes, result in enhanced circulation lifetimes relative to liposomes lacking such specialized lipids. Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome (A) comprises one or more glycolipids, such as monosialoganglioside GM1, or (B) is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety. While not wishing to be bound by any particular theory, it is thought in the art that, at least for sterically stabilized liposomes containing gangliosides, sphingomyelin, or PEG-derivatized lipids, the enhanced circulation half-life of these sterically stabilized liposomes derives from a reduced uptake into cells of the reticuloendothelial system (RES) (Allen et al., FEBS Letters, 1987, 223, 42; Wu et al., Cancer Research, 1993, 53, 3765).
Various liposomes comprising one or more glycolipids are known in the art. Papahadjopoulos et al. (Ann. N.Y. Acad. Sci., 1987, 507, 64) reported the ability of monosialoganglioside GM1, galactocerebroside sulfate and phosphatidylinositol to improve blood half-lives of liposomes. These findings were expounded upon by Gabizon et al. (Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 6949). U.S. Pat. No. 4,837,028 and WO 88/04924, both to Allen et al., disclose liposomes comprising (1) sphingomyelin and (2) the ganglioside GM1 or a galactocerebroside sulfate ester. U.S. Pat. No. 5,543,152 (Webb et al.) discloses liposomes comprising sphingomyelin. Liposomes comprising 1,2-sn-dimyristoylphosphat-idylcholine are disclosed in WO 97/13499 (Lim et al).
Many liposomes comprising lipids derivatized with one or more hydrophilic polymers, and methods of preparation thereof, are known in the art. Sunamoto et al. (Bull. Chem. Soc. Jpn., 1980, 53, 2778) described liposomes comprising a nonionic detergent, 2C1215G, that contains a PEG moiety. Ilium et al. (FEBS Lett., 1984, 167, 79) noted that hydrophilic coating of polystyrene particles with polymeric glycols results in significantly enhanced blood half-lives. Synthetic phospholipids modified by the attachment of carboxylic groups of polyalkylene glycols (e.g., PEG) are described by Sears (U.S. Pat. Nos. 4,426,330 and 4,534,899). Klibanov et al. (FEBS Lett., 1990, 268, 235) described experiments demonstrating that liposomes comprising phosphatidylethanolamine (PE) derivatized with PEG or PEG stearate have significant increases in blood circulation half-lives. Blume et al. (Biochimica et Biophysica Acta, 1990, 1029, 91) extended such observations to other PEG-derivatized phospholipids, e.g., DSPE-PEG, formed from the combination of distearoylphosphatidylethanolamine (DSPE) and PEG. Liposomes having covalently bound PEG moieties on their external surface are described in European Patent No. EP 0 445 131 B1 and WO 90/04384 to Fisher. Liposome compositions containing 1-20 mole percent of PE derivatized with PEG, and methods of use thereof, are described by Woodle et al. (U.S. Pat. Nos. 5,013,556 and 5,356,633) and Martin et al. (U.S. Pat. No. 5,213,804 and European Patent No. EP 0 496 813 B1). Liposomes comprising a number of other lipid-polymer conjugates are disclosed in WO 91/05545 and U.S. Pat. No. 5,225,212 (both to Martin et al.) and in WO 94/20073 (Zalipsky et al.) Liposomes comprising PEG-modified ceramide lipids are described in WO 96/10391 (Choi et al). U.S. Pat. No. 5,540,935 (Miyazaki et al.) and U.S. Pat. No. 5,556,948 (Tagawa et al.) describe PEG-containing liposomes that can be further derivatized with functional moieties on their surfaces.
A number of liposomes comprising nucleic acids are known in the art. WO 96/40062 to Thierry et al. discloses methods for encapsulating high molecular weight nucleic acids in liposomes. U.S. Pat. No. 5,264,221 to Tagawa et al. discloses protein-bonded liposomes and asserts that the contents of such liposomes may include a dsRNA. U.S. Pat. No. 5,665,710 to Rahman et al. describes certain methods of encapsulating oligodeoxynucleotides in liposomes. WO 97/04787 to Love et al. discloses liposomes comprising dsRNAs targeted to the raf gene.
Transfersomes are yet another type of liposomes, and are highly deformable lipid aggregates which are attractive candidates for drug delivery vehicles. Transfersomes may be described as lipid droplets which are so highly deformable that they are easily able to penetrate through pores which are smaller than the droplet. Transfersomes are adaptable to the environment in which they are used, e.g., they are self-optimizing (adaptive to the shape of pores in the skin), self-repairing, frequently reach their targets without fragmenting, and often self-loading. To make transfersomes it is possible to add surface edge-activators, usually surfactants, to a standard liposomal composition. Transfersomes have been used to deliver serum albumin to the skin. The transfersome-mediated delivery of serum albumin has been shown to be as effective as subcutaneous injection of a solution containing serum albumin.
Surfactants find wide application in formulations such as emulsions (including microemulsions) and liposomes. The most common way of classifying and ranking the properties of the many different types of surfactants, both natural and synthetic, is by the use of the hydrophile/lipophile balance (HLB). The nature of the hydrophilic group (also known as the “head”) provides the most useful means for categorizing the different surfactants used in formulations (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N.Y., 1988, p. 285).
If the surfactant molecule is not ionized, it is classified as a nonionic surfactant. Nonionic surfactants find wide application in pharmaceutical and cosmetic products and are usable over a wide range of pH values. In general their HLB values range from 2 to about 18 depending on their structure. Nonionic surfactants include nonionic esters such as ethylene glycol esters, propylene glycol esters, glyceryl esters, polyglyceryl esters, sorbitan esters, sucrose esters, and ethoxylated esters. Nonionic alkanolamides and ethers such as fatty alcohol ethoxylates, propoxylated alcohols, and ethoxylated/propoxylated block polymers are also included in this class. The polyoxyethylene surfactants are the most popular members of the nonionic surfactant class.
If the surfactant molecule carries a negative charge when it is dissolved or dispersed in water, the surfactant is classified as anionic. Anionic surfactants include carboxylates such as soaps, acyl lactylates, acyl amides of amino acids, esters of sulfuric acid such as alkyl sulfates and ethoxylated alkyl sulfates, sulfonates such as alkyl benzene sulfonates, acyl isethionates, acyl taurates and sulfosuccinates, and phosphates. The most important members of the anionic surfactant class are the alkyl sulfates and the soaps.
If the surfactant molecule carries a positive charge when it is dissolved or dispersed in water, the surfactant is classified as cationic. Cationic surfactants include quaternary ammonium salts and ethoxylated amines. The quaternary ammonium salts are the most used members of this class.
If the surfactant molecule has the ability to carry either a positive or negative charge, the surfactant is classified as amphoteric. Amphoteric surfactants include acrylic acid derivatives, substituted alkylamides, N-alkylbetaines and phosphatides.
The use of surfactants in drug products, formulations and in emulsions has been reviewed (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N.Y., 1988, p. 285).
Nucleic Acid Lipid Particles
In one embodiment, a dsRNA featured in the invention is fully encapsulated in the lipid formulation to form a SPLP, pSPLP, SNALP, or other nucleic acid-lipid particle. As used herein, the term “SNALP” refers to a stable nucleic acid-lipid particle, including SPLP. As used herein, the term “SPLP” refers to a nucleic acid-lipid particle comprising plasmid DNA encapsulated within a lipid vesicle. SNALPs and SPLPs typically contain a cationic lipid, a non-cationic lipid, and a lipid that prevents aggregation of the particle (e.g., a PEG-lipid conjugate). SNALPs and SPLPs are extremely useful for systemic applications, as they exhibit extended circulation lifetimes following intravenous (i.v.) injection and accumulate at distal sites (e.g., sites physically separated from the administration site). SPLPs include “pSPLP,” which include an encapsulated condensing agent-nucleic acid complex as set forth in PCT Publication No. WO 00/03683. The particles of the present invention typically have a mean diameter of about 50 nm to about 150 nm, more typically about 60 nm to about 130 nm, more typically about 70 nm to about 110 nm, most typically about 70 to about 90 nm, and are substantially nontoxic. In addition, the nucleic acids when present in the nucleic acid-lipid particles of the present invention are resistant in aqueous solution to degradation with a nuclease. Nucleic acid-lipid particles and their method of preparation are disclosed in, e.g., U.S. Pat. Nos. 5,976,567; 5,981,501; 6,534,484; 6,586,410; 6,815,432; and PCT Publication No. WO 96/40964.
In one embodiment, the lipid to drug ratio (mass/mass ratio) (e.g., lipid to dsRNA ratio) will be in the range of from about 1:1 to about 50:1, from about 1:1 to about 25:1, from about 3:1 to about 15:1, from about 4:1 to about 10:1, from about 5:1 to about 9:1, or about 6:1 to about 9:1.
The cationic lipid may be, for example, N,N-dioleyl-N,N-dimethylammonium chloride (DODAC), N,N-distearyl-N,N-dimethylammonium bromide (DDAB), N-(I-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTAP), N-(I-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTMA), N,N-dimethyl-2,3-dioleyloxy)propylamine (DODMA), 1,2-DiLinoleyloxy-N,N-dimethylaminopropane (DLinDMA), 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA), 1,2-Dilinoleylcarbamoyloxy-3-dimethylaminopropane (DLin-C-DAP), 1,2-Dilinoleyoxy-3-(dimethylamino)acetoxypropane (DLin-DAC), 1,2-Dilinoleyoxy-3-morpholinopropane (DLin-MA), 1,2-Dilinoleoyl-3-dimethylaminopropane (DLinDAP), 1,2-Dilinoleylthio-3-dimethylaminopropane (DLin-S-DMA), 1-Linoleoyl-2-linoleyloxy-3-dimethylaminopropane (DLin-2-DMAP), 1,2-Dilinoleyloxy-3-trimethylaminopropane chloride salt (DLin-TMA.Cl), 1,2-Dilinoleoyl-3-trimethylaminopropane chloride salt (DLin-TAP.Cl), 1,2-Dilinoleyloxy-3-(N-methylpiperazino)propane (DLin-MPZ), or 3-(N,N-Dilinoleylamino)-1,2-propanediol (DLinAP), 3-(N,N-Dioleylamino)-1,2-propanedio (DOAP), 1,2-Dilinoleyloxo-3-(2-N,N-dimethylamino)ethoxypropane (DLin-EG-DMA), 2,2-Dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA) or analogs thereof, or a mixture thereof. The cationic lipid may comprise from about 20 mol % to about 50 mol % or about 40 mol % of the total lipid present in the particle.
In another embodiment, the compound 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane can be used to prepare lipid-siRNA nanoparticles. Synthesis of 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane is described in U.S. provisional patent application No. 61/107,998 filed on Oct. 23, 2008, which is herein incorporated by reference.
In one embodiment, the lipid-siRNA particle includes 40% 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane: 10% DSPC: 40% Cholesterol: 10% PEG-C-DOMG (mole percent) with a particle size of 63.0±20 nm and a 0.027 siRNA/Lipid Ratio.
The non-cationic lipid may be an anionic lipid or a neutral lipid including, but not limited to, distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylglycerol (DOPG), dipalmitoylphosphatidylglycerol (DPPG), dioleoyl-phosphatidylethanolamine (DOPE), palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylethanolamine (POPE), dioleoyl-phosphatidylethanolamine 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (DOPE-mal), dipalmitoyl phosphatidyl ethanolamine (DPPE), dimyristoylphosphoethanolamine (DMPE), distearoyl-phosphatidyl-ethanolamine (DSPE), 16-O-monomethyl PE, 16-O-dimethyl PE, 18-1-trans PE, 1-stearoyl-2-oleoyl-phosphatidyethanolamine (SOPE), cholesterol, or a mixture thereof. The non-cationic lipid may be from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle.
The conjugated lipid that inhibits aggregation of particles may be, for example, a polyethyleneglycol (PEG)-lipid including, without limitation, a PEG-diacylglycerol (DAG), a PEG-dialkyloxypropyl (DAA), a PEG-phospholipid, a PEG-ceramide (Cer), or a mixture thereof. The PEG-DAA conjugate may be, for example, a PEG-dilauryloxypropyl (Ci2), a PEG-dimyristyloxypropyl (Ci4), a PEG-dipalmityloxypropyl (Ci6), or a PEG-distearyloxypropyl (C]8). The conjugated lipid that prevents aggregation of particles may be from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.
In some embodiments, the nucleic acid-lipid particle further includes cholesterol at, e.g., about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle.
LNP01
In one embodiment, the lipidoid ND98.4HCl (MW 1487) (Formula 1), Cholesterol (Sigma-Aldrich), and PEG-Ceramide C16 (Avanti Polar Lipids) can be used to prepare lipid-siRNA nanoparticles (i.e., LNP01 particles). Stock solutions of each in ethanol can be prepared as follows: ND98, 133 mg/ml; Cholesterol, 25 mg/ml, PEG-Ceramide C16, 100 mg/ml. The ND98, Cholesterol, and PEG-Ceramide C16 stock solutions can then be combined in a, e.g., 42:48:10 molar ratio. The combined lipid solution can be mixed with aqueous siRNA (e.g., in sodium acetate pH 5) such that the final ethanol concentration is about 35-45% and the final sodium acetate concentration is about 100-300 mM. Lipid-siRNA nanoparticles typically form spontaneously upon mixing. Depending on the desired particle size distribution, the resultant nanoparticle mixture can be extruded through a polycarbonate membrane (e.g., 100 nm cut-off) using, for example, a thermobarrel extruder, such as Lipex Extruder (Northern Lipids, Inc). In some cases, the extrusion step can be omitted. Ethanol removal and simultaneous buffer exchange can be accomplished by, for example, dialysis or tangential flow filtration. Buffer can be exchanged with, for example, phosphate buffered saline (PBS) at about pH 7, e.g., about pH 6.9, about pH 7.0, about pH 7.1, about pH 7.2, about pH 7.3, or about pH 7.4.




LNP01 formulations are described, e.g., in International Application Publication No. WO 2008/042973, which is hereby incorporated by reference.
As mentioned above, the lipid-dsRNA particle can comprise a cationic lipid, a neutral lipid, a steroid, and optionally a lipid that prevents aggregation of the particle. The relative percentages of these constituents can vary depending on the type of lipids used. However, in general, the cationic lipid comprises from about 20 mol % to about 70 mol % or about 40 mol % to about 60 mol % of the total lipid present in the particle; neutral lipids comprise from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle; the steroid (typically cholesterol) can comprise from about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle; finally, the lipid that prevents aggregation of the particle, typically a conjugated lipid (e.g., a PEG-conjugated lipid) can comprise from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.
In one embodiment, the lipid-dsRNA particle includes 40 mol % 2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane, 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 40 mol % Cholesterol, 10 mol % PEG-C-DOMG with a particle size of 63.0±20 nm and a 0.027 dsRNA/Lipid Ratio.
In another embodiment, the lipid-dsRNA particle includes 40 mol % 1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane (DLinDMA), 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 2 mol % 3-N-[(qmethoxypoly(ethylene glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine (PEG-C-DMA), and 48 mol % cholesterol.
In another embodiment, the lipid-dsRNA particle includes 57.1 mol % 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLinDMA), 7.1 mol % DPPC, 34.4 mol % Cholesterol, 1.4 mol % PEG-cDMA.
In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid DLinDMA (1,2-dilinoleyloxy-3-(N,N-dimethyl)aminopropane).
In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane.
Additional exemplary lipid-siRNA formulations are as follows:
















cationic lipid/non-cationic





lipid//choleseterol/PEG-lipid conjugate



Cationic Lipid
Lipid:siRNA ratio
Process



















LNP05
2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG
Extrusion



dimethylaminoethyl-
57.5/7.5/31.5/3.5



[1,3]-dioxolane (XTC)
lipid:siRNA ~ 6:1


LNP06
2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG
Extrusion



dimethylaminoethyl-
57.5/7.5/31.5/3.5



[1,3]-dioxolane (XTC)
lipid:siRNA ~ 11:1


LNP07
2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG
In-line



dimethylaminoethyl-
60/7.5/31/1.5,
mixing



[1,3]-dioxolane (XTC)
lipid:siRNA ~ 6:1


LNP08
2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG
In-line



dimethylaminoethyl-
60/7.5/31/1.5,
mixing



[1,3]-dioxolane (XTC)
lipid:siRNA ~ 11:1


LNP09
2,2-Dilinoleyl-4-
XTC/DSPC/Cholesterol/PEG-DMG
In-line



dimethylaminoethyl-
50/10/38.5/1.5
mixing



[1,3]-dioxolane (XTC)
Lipid:siRNA 10:1


SNALP
1,2-Dilinolenyloxy-
DLinDMA/DPPC/Cholesterol/PEG-cDMA



N,N-
(57.1/7.1/34.4/1.4)



dimethylaminopropane
lipid:siRNA ~ 7:1



(DLinDMA)


SNALP-
2,2-Dilinoleyl-4-
XTC/DPPC/Cholesterol/PEG-cDMA


XTC
dimethylaminoethyl-
57.1/7.1/34.4/1.4



[1,3]-dioxolane (XTC)
lipid:siRNA ~ 7:1









Characterization of Lipid Formulated dsRNAs
Formulations prepared by either the in-line mixing or extrusion-free method can be characterized in similar manners. For example, formulations are typically characterized by visual inspection. They should be whitish translucent solutions free from aggregates or sediment. Particle size and particle size distribution of lipid-nanoparticles can be measured by light scattering using, for example, a Malvern Zetasizer Nano Z S (Malvern, USA). Particles should be about 20-300 nm, such as 40-100 nm in size. The particle size distribution should be unimodal. The total siRNA concentration in the formulation, as well as the entrapped fraction, is estimated using a dye exclusion assay. A sample of the formulated siRNA can be incubated with an RNA-binding dye, such as Ribogreen (Molecular Probes) in the presence or absence of a formulation disrupting surfactant, e.g., 0.5% Triton-X100. The total siRNA in the formulation can be determined by the signal from the sample containing the surfactant, relative to a standard curve. The entrapped fraction is determined by subtracting the “free” siRNA content (as measured by the signal in the absence of surfactant) from the total siRNA content. Percent entrapped siRNA is typically >85%. For SNALP formulation, the particle size is at least 30 nm, at least 40 nm, at least 50 nm, at least 60 nm, at least 70 nm, at least 80 nm, at least 90 nm, at least 100 nm, at least 110 nm, and at least 120 nm. The suitable range is typically about at least 50 nm to about at least 110 nm, about at least 60 nm to about at least 100 nm, or about at least 80 nm to about at least 90 nm.
Penetration Enhancers
In one embodiment, the present invention employs various penetration enhancers to effect the efficient delivery of nucleic acids, particularly dsRNAs, to the skin of animals. Most drugs are present in solution in both ionized and nonionized forms. However, usually only lipid soluble or lipophilic drugs readily cross cell membranes. It has been discovered that even non-lipophilic drugs may cross cell membranes if the membrane to be crossed is treated with a penetration enhancer. In addition to aiding the diffusion of non-lipophilic drugs across cell membranes, penetration enhancers also enhance the permeability of lipophilic drugs.
Penetration enhancers may be classified as belonging to one of five broad categories, i.e., surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of the above mentioned classes of penetration enhancers are described below in greater detail.
Surfactants:
In connection with the present invention, surfactants (or “surface-active agents”) are chemical entities which, when dissolved in an aqueous solution, reduce the surface tension of the solution or the interfacial tension between the aqueous solution and another liquid, with the result that absorption of dsRNAs through the mucosa is enhanced. In addition to bile salts and fatty acids, these penetration enhancers include, for example, sodium lauryl sulfate, polyoxyethylene-9-lauryl ether and polyoxyethylene-20-cetyl ether) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92); and perfluorochemical emulsions, such as FC-43. Takahashi et al., J. Pharm. Pharmacol., 1988, 40, 252).
Fatty Acids:
Various fatty acids and their derivatives which act as penetration enhancers include, for example, oleic acid, lauric acid, capric acid (n-decanoic acid), myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein (1-monooleoyl-rac-glycerol), dilaurin, caprylic acid, arachidonic acid, glycerol 1-monocaprate, 1-dodecylazacycloheptan-2-one, acylcarnitines, acylcholines, C.sub.1-10 alkyl esters thereof (e.g., methyl, isopropyl and t-butyl), and mono- and di-glycerides thereof (i.e., oleate, laurate, caprate, myristate, palmitate, stearate, linoleate, etc.) (Lee et al., Critical Reviews in Therapeutic Drug Carryier Systems, 1991, p. 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; El Hariri et al., J. Pharm. Pharmacol., 1992, 44, 651-654).
Bile Salts:
The physiological role of bile includes the facilitation of dispersion and absorption of lipids and fat-soluble vitamins (Brunton, Chapter 38 in: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., Hardman et al. Eds., McGraw-Hill, New York, 1996, pp. 934-935). Various natural bile salts, and their synthetic derivatives, act as penetration enhancers. Thus the term “bile salts” includes any of the naturally occurring components of bile as well as any of their synthetic derivatives. The bile salts of the invention include, for example, cholic acid (or its pharmaceutically acceptable sodium salt, sodium cholate), dehydrocholic acid (sodium dehydrocholate), deoxycholic acid (sodium deoxycholate), glucholic acid (sodium glucholate), glycholic acid (sodium glycocholate), glycodeoxycholic acid (sodium glycodeoxycholate), taurocholic acid (sodium taurocholate), taurodeoxycholic acid (sodium taurodeoxycholate), chenodeoxycholic acid (sodium chenodeoxycholate), ursodeoxycholic acid (UDCA), sodium tauro-24,25-dihydro-fusidate (STDHF), sodium glycodihydrofusidate and polyoxyethylene-9-lauryl ether (POE) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Swinyard, Chapter 39 In: Remington's Pharmaceutical Sciences, 18th Ed., Gennaro, ed., Mack Publishing Co., Easton, Pa., 1990, pages 782-783; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Yamamoto et al., J. Pharm. Exp. Ther., 1992, 263, 25; Yamashita et al., J. Pharm. Sci., 1990, 79, 579-583).
Chelating Agents:
Chelating agents, as used in connection with the present invention, can be defined as compounds that remove metallic ions from solution by forming complexes therewith, with the result that absorption of dsRNAs through the mucosa is enhanced. With regards to their use as penetration enhancers in the present invention, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J. Chromatogr., 1993, 618, 315-339). Chelating agents of the invention include but are not limited to disodium ethylenediaminetetraacetate (EDTA), citric acid, salicylates (e.g., sodium salicylate, 5-methoxysalicylate and homovanilate), N-acyl derivatives of collagen, laureth-9 and N-amino acyl derivatives of beta-diketones (enamines)(Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Buur et al., J. Control Rel., 1990, 14, 43-51).
Non-Chelating Non-Surfactants:
As used herein, non-chelating non-surfactant penetration enhancing compounds can be defined as compounds that demonstrate insignificant activity as chelating agents or as surfactants but that nonetheless enhance absorption of dsRNAs through the alimentary mucosa (Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33). This class of penetration enhancers include, for example, unsaturated cyclic ureas, 1-alkyl- and 1-alkenylazacyclo-alkanone derivatives (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92); and non-steroidal anti-inflammatory agents such as diclofenac sodium, indomethacin and phenylbutazone (Yamashita et al., J. Pharm. Pharmacol., 1987, 39, 621-626).
Agents that enhance uptake of dsRNAs at the cellular level may also be added to the pharmaceutical and other compositions of the present invention. For example, cationic lipids, such as lipofectin (Junichi et al, U.S. Pat. No. 5,705,188), cationic glycerol derivatives, and polycationic molecules, such as polylysine (Lollo et al., PCT Application WO 97/30731), are also known to enhance the cellular uptake of dsRNAs.
Other agents may be utilized to enhance the penetration of the administered nucleic acids, including glycols such as ethylene glycol and propylene glycol, pyrrols such as 2-pyrrol, azones, and terpenes such as limonene and menthone.
Carriers
Certain compositions of the present invention also incorporate carrier compounds in the formulation. As used herein, “carrier compound” or “carrier” can refer to a nucleic acid, or analog thereof, which is inert (i.e., does not possess biological activity per se) but is recognized as a nucleic acid by in vivo processes that reduce the bioavailability of a nucleic acid having biological activity by, for example, degrading the biologically active nucleic acid or promoting its removal from circulation. The coadministration of a nucleic acid and a carrier compound, typically with an excess of the latter substance, can result in a substantial reduction of the amount of nucleic acid recovered in the liver, kidney or other extracirculatory reservoirs, presumably due to competition between the carrier compound and the nucleic acid for a common receptor. For example, the recovery of a partially phosphorothioate dsRNA in hepatic tissue can be reduced when it is coadministered with polyinosinic acid, dextran sulfate, polycytidic acid or 4-acetamido-4′ isothiocyano-stilbene-2,2′-disulfonic acid (Miyao et al., DsRNA Res. Dev., 1995, 5, 115-121; Takakura et al., DsRNA & Nucl. Acid Drug Dev., 1996, 6, 177-183.
Excipients
In contrast to a carrier compound, a “pharmaceutical carrier” or “excipient” is a pharmaceutically acceptable solvent, suspending agent or any other pharmacologically inert vehicle for delivering one or more nucleic acids to an animal. The excipient may be liquid or solid and is selected, with the planned manner of administration in mind, so as to provide for the desired bulk, consistency, etc., when combined with a nucleic acid and the other components of a given pharmaceutical composition. Typical pharmaceutical carriers include, but are not limited to, binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose, etc.); fillers (e.g., lactose and other sugars, microcrystalline cellulose, pectin, gelatin, calcium sulfate, ethyl cellulose, polyacrylates or calcium hydrogen phosphate, etc.); lubricants (e.g., magnesium stearate, talc, silica, colloidal silicon dioxide, stearic acid, metallic stearates, hydrogenated vegetable oils, corn starch, polyethylene glycols, sodium benzoate, sodium acetate, etc.); disintegrants (e.g., starch, sodium starch glycolate, etc.); and wetting agents (e.g., sodium lauryl sulphate, etc).
Pharmaceutically acceptable organic or inorganic excipient suitable for non-parenteral administration which do not deleteriously react with nucleic acids can also be used to formulate the compositions of the present invention. Suitable pharmaceutically acceptable carriers include, but are not limited to, water, salt solutions, alcohols, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.
Formulations for topical administration of nucleic acids may include sterile and non-sterile aqueous solutions, non-aqueous solutions in common solvents such as alcohols, or solutions of the nucleic acids in liquid or solid oil bases. The solutions may also contain buffers, diluents and other suitable additives. Pharmaceutically acceptable organic or inorganic excipients suitable for non-parenteral administration which do not deleteriously react with nucleic acids can be used.
Suitable pharmaceutically acceptable excipients include, but are not limited to, water, salt solutions, alcohol, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.
Other Components
The compositions of the present invention may additionally contain other adjunct components conventionally found in pharmaceutical compositions, at their art-established usage levels. Thus, for example, the compositions may contain additional, compatible, pharmaceutically-active materials such as, for example, antipruritics, astringents, local anesthetics or anti-inflammatory agents, or may contain additional materials useful in physically formulating various dosage forms of the compositions of the present invention, such as dyes, flavoring agents, preservatives, antioxidants, opacifiers, thickening agents and stabilizers. However, such materials, when added, should not unduly interfere with the biological activities of the components of the compositions of the present invention. The formulations can be sterilized and, if desired, mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, colorings, flavorings and/or aromatic substances and the like which do not deleteriously interact with the nucleic acid(s) of the formulation.
Aqueous suspensions may contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.
Certain embodiments of the invention provide pharmaceutical compositions containing (a) one or more antisense compounds and (b) one or more other chemotherapeutic agents which function by a non-antisense mechanism. Examples of such chemotherapeutic agents include but are not limited to daunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphor-amide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the compounds of the invention, such chemotherapeutic agents may be used individually (e.g., 5-FU and oligonucleotide), sequentially (e.g., 5-FU and oligonucleotide for a period of time followed by MTX and oligonucleotide), or in combination with one or more other such chemotherapeutic agents (e.g., 5-FU, MTX and oligonucleotide, or 5-FU, radiotherapy and oligonucleotide). Anti-inflammatory drugs, including but not limited to nonsteroidal anti-inflammatory drugs and corticosteroids, and antiviral drugs, including but not limited to ribivirin, vidarabine, acyclovir and ganciclovir, may also be combined in compositions of the invention. See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed., Berkow et al., eds., 1987, Rahway, N.J., pages 2499-2506 and 46-49, respectively). Other non-antisense chemotherapeutic agents are also within the scope of this invention. Two or more combined compounds may be used together or sequentially.
Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds which exhibit high therapeutic indices are preferred.
The data obtained from cell culture assays and animal studies can be used in formulation a range of dosage for use in humans. The dosage of compositions of the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.
In addition to their administration, as discussed above, the dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by GSK-3 expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.
Methods for Treating Diseases Caused by Expression of a GSK-3 Gene
The invention relates in particular to the use of a dsRNA targeting GSK-3 and compositions containing at least one such dsRNA, for the treatment of a GSK-3-mediated disorder or disease. For example, a dsRNA targeting a GSK-3 gene can be useful for the treatment of manic depression.
Other disorders which can be treated with the compounds, compositions and methods described herein include a metabolic disease, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS or nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), and are also provided. The dsRNAs described here can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.
“Metabolic syndrome” is characterized by a group of metabolic risk factors including: abdominal obesity (excessive fat tissue in and around the abdomen), atherogenic dyslipidemia (blood fat disorders (including high triglycerides, low HDL cholesterol and high LDL cholesterol) that foster plaque build-up in artery walls), elevated blood pressure, insulin resistance or glucose intolerance (due to the body's inability to properly use insulin or blood sugar), a prothrombotic state (e.g., high fibrinogen or plasminogen activator inhibitor-1 in the blood), and a proinflammatory state (e.g., elevated C-reactive protein in the blood). People with metabolic syndrome are at increased risk of coronary heart disease and other diseases related to plaque buildups in artery walls (e.g., stroke and peripheral vascular disease), and Type II diabetes. Other metabolic diseases suitable for treatment with a dsRNA targeting GSK-3 include obesity and insulin resistance.
A dsRNA targeting GSK-3 can be also be useful for the treatment of cancer, such as a colorectal cancer.
A composition containing a dsRNA targeting GSK-3 may also be used to treat other tumors and cancers, such as breast cancer, lung cancer, head and neck cancer, brain cancer, abdominal cancer, colon cancer, colorectal cancer, esophagus cancer, gastrointestinal cancer, glioma, tongue cancer, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, retinoblastoma, Wilm's tumor, multiple myeloma and for the treatment of skin cancer, like melanoma, for the treatment of lymphomas and blood cancer.
Owing to the inhibitory effects on GSK-3 expression, a composition according to the invention or a pharmaceutical composition prepared therefrom can enhance the quality of life.
The invention further relates to the use of a dsRNA or a pharmaceutical composition thereof, e.g., for treating manic depression or another disorder described herein, in combination with other pharmaceuticals and/or other therapeutic methods, e.g., with known pharmaceuticals and/or known therapeutic methods, such as, for example, those which are currently employed for treating these disorders.
For example, in the treatment of manic depression, the patient can also be treated with one or more other therapeutic modalities, e.g., lithium salts, anticonvulsant mood stabilizers, antipsychotics, and other adjunctive treatments described herein. In an embodiment the patient is also treated with lithium salts. Lithium salts have been used as a first-line treatment for bipolar disorder. Common lithium salts are lithium carbonate and (probably less commonly) lithium citrate. Lithium orotate is used as an alternative treatment to lithium carbonate by some individuals with bipolar disorder. In an embodiment the patient is also treated with an anticonvulsant mood stabilizer. Anticonvulsant medications, particularly valproate and carbamazepine, have been used as alternatives or adjuncts to lithium in many cases. Valproate (Depakote, Epival) was FDA approved for the treatment of acute mania in 1995, and is now considered by some doctors to be the first line of therapy for bipolar disorder. A similar medication, valproic acid (Depakene) is also used. Anticonvulsants are also used in combination with antipsychotics. Newer anticonvulsant medications, including lamotrigine and oxcarbazepine, are also effective as mood stabilizers in bipolar disorder. Lamotrigine is particularly promising, as it alleviates bipolar depression and prevents recurrence at higher rates. Zonisamide (trade name Zonegran), another anticonvulsant, also may show promise in treating bipolar depression. Topiramate maybe useful for some patients. It appears to be useful in some treatment resistant cases and for anxiety issues when clonazepam cannot be prescribed. Other anticonvulsants effective in some cases and under study include phenyloin, levetiracetam, pregabalin and valnoctamide. In an embodiment the patient is also treated with an “atypical antipsychotic drug.” The newer atypical antipsychotic drugs such as risperidone, quetiapine, and olanzapine are often used in acutely manic patients. In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. Eli Lilly and Company also offers Symbyax, a combination of olanzapine and fluoxetine. Ziprasidone (Geodon) and aripriprazole (Abilify) also show promise. Other newer treatments include Modafinil (Provigil) and Pramipexole (Mirapex), which show promise in treating the cognitive deterioration related to bipolar depression. In addition Riluzole, an ALS treatment, has been shown to be effective treatment. The breast cancer medicine tamoxifen has shown quick response to manic phases. In an embodiment the patient is also treated with electroconvulsive therapy. Electroconvulsive therapy (ECT) is sometimes used to treat severe bipolar depression in cases where other treatments have failed and is 60 to 70 percent effective. In an embodiment the patient is also treated with psychotherapy. Other treatments include omega-3 fatty acids, particularly as a supplement to other medication. There are also reports that medical marijuana can help control the mood swings in some forms of bipolar disorder.
In an embodiment a dsRNA described herein is administered to a patient who has previously been treated with another therapeutic or counseling modality but which has provided less than optimal results.
In the example of a metabolic disorder, e.g., diabetes, the patient can also be provided administration of a dsRNA targeting GSK-3 can be accompanied by a exercise regimen or by dietary restrictions. A dsRNA featured in the invention can also be administered with a drug or combination of drugs for managing Type II diabetes, e.g., a sulfonylurea, a biguanide, an alpha-glucosidase inhibitor, a thiazolidinedione, a meglitinide, a D-phenylalanine derivative, an amylin synthetic derivatives, an incretin mimetic, or an insulin. Exemplary insulins include regular insulins (Humulin®, Novolin®), insulin lispro (Humalog®), insulin aspart (Novolog®), insulin glulisine (Apidra®), prompt insulin zinc (Semilente®, slightly slower acting), inhaled insulin (Exubera®), intermediate-acting insulins, isophane insulin, neutral protamine Hagedorn (NPH), insulin zinc (Lente®), extended insulin zinc insulin (Ultralente®), insulin glargine (Lantus®), and insulin detemir (Levemir®).
In the example of cancerthe patient can also be provided with a chemotherapy agent, such as deoxycoformycin, cisplatin, cyclophosphamide, 5-fluorouracil, adriamycin, daunorubicin, tamoxifen aunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphoramide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the dsRNAs featured in the invention, such chemotherapeutic agents may be used individually (e.g., deoxycoformycin and dsRNA), sequentially (e.g., antiviral and dsRNA for a period of time, followed by deoxycoformycin and dsRNA), or in combination with one or more other such agents (e.g., deoxycoformycin, antiviral and dsRNA, or deoxycoformycin, radiotherapy and dsRNA). Two or more combined compounds may be used together or sequentially.
Generally, the dsRNAs described here can be used in combination with other GSK-3 inhibitors. Examples of such inhibitors described in Meijer et al., Trends in Pharmacological Sciences, 25: 471 (September 2004), incorporated herein by reference include pyrroloazepines, (e.g., hymenialdisine), flavones (e.g., flavopiridol), benzazepinones (e.g., kenpaullone, alsterpaulione, and azakenpaullone), bis-indole indirubin-3′-oximes (e.g., indirubin-3′-oxime, 6-bromoindirubin-3′-oxime (BIO), and 6-bromoindirubin-3′-acetoxime), pyrrolopyrazines (e.g., aloisine A and aloisine B), thiadiazolidinones (e.g., TDZD8), pyridyloxadiazoles (e.g., Compound 12), pyrazolopyridines (e.g., pyrazolopyridine 18 and pyrazolopyridine 34), pyrazolopyridazines (e.g., pyrazolopyridine 9), aminopyrimidines (e.g., CHIR98014 and CHIR99021 (CT99021)), pyrazoloquinoxalines (Compound 1), oxindoles (indolinones) (e.g., SU9516), thiazoles (e.g., ARA014418), bisindolylmaleimides (e.g., staurosporine and Compound 5a), azaindolylmaleimides (e.g., Compound 29 and Compound 46), bisindolylmaleimides (e.g., GF109203x (bisindolylmaleimide I) and Ro318220 (bisindolylmaleimide IX)), arylindolemaleimides (e.g., SB216763), anilinomaleimides (e.g., SB415286), anilinoarylmaleimides (e.g., I5), phenylaminopyrimidines (e.g., CGP60474), triazoles (e.g., Compound 8b), pyrrolopyrimidines (e.g., TWS119), pyrazolopyrimidines (e.g., Compound 1A), chloromethyl thienyl ketone (e.g., Compound 17), atoms in competition with Mg2+ (e.g., lithium), atoms in competition with Mg2+ and ATP (e.g., beryllium), and uncompetitive atoms (e.g., zinc). Structures for some of the inhibitors can be found in FIG. 2 of Meijer et al. and are shown below.
















Methods for Inhibiting Expression of the GSK-3 Gene

In yet another aspect, the invention provides a method for inhibiting the expression of an GSK-3 gene in a mammal. The method includes administering a composition featured in the invention to the mammal such that expression of the target GSK-3 gene is silenced.
When the organism to be treated is a mammal such as a human, the composition may be administered by any means known in the art including, but not limited to oral or parenteral routes, including intravenous, intramuscular, subcutaneous, transdermal, airway (aerosol), nasal, rectal, and topical (including buccal and sublingual) administration. In preferred embodiments, the compositions are administered by intravenous infusion or injection.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.
EXAMPLE
Example 1
Design and Synthesis of siRNA Targeting GSK3
siRNA Design for Mouse Glycogen Synthase Kinase 3 Alpha (GSK3α)
All possible perfect match sense 19mer oligomers were extracted from mouse GSKalpha sequence NM—001031667.1, the sole NCBI reference sequence for the mouse GSK3α gene, and identified as candidate target regions. The sequences are shown in Table 1 below.
In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.
To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8.).
The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

    
    
        1. Number of mismatches in seed region, defined as positions 2-9 of the oligomer
        2. Number of mismatches in cleavage site region, defined as positions 10 and 11
        3. Number of mismatches in non-seed region, non-cleavage region, defined as positions 12-19
        4. Mismatches in position 1 were ignored
    
    


The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:

Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)

The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse GSK3α transcript measured. The sequences are shown in Table 4.
Sense and antisense oligomers complementary to the human GSK3α gene (NM—002093) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 6.
siRNA Design for Mouse Glycogen Synthase Kinase 3 Beta (GSK3β)
All possible perfect match sense 19mer oligomers were extracted from NM—019827.4 the sole NCBI reference sequence for the mouse Gsk3β gene, and identified as candidate target regions. The sequences are shown in Table 2.
In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.
To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8).
The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

    
    
        1. Number of mismatches in seed region, defined as positions 2-9 of the oligomer
        2. Number of mismatches in cleavage site region, defined as positions 10 and 11
        3. Number of mismatches in non-seed region, non-cleavage region, defined as positions 12-19
        4. Mismatches in position 1 were ignored
    
    


The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:

Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)

The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse Gsk3β transcript measured. The sequences are shown in Table 5.
Sense and antisense oligomers complementary to the human GSK3β gene (NM—019884.2) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 7.
Table 3 provides a description of the abbreviations used herein.







TABLE 3







Abbreviations of nucleotide monomers used in nucleic acid sequence


representation. It will be understood that these monomers, when present in


an oligonucleotide, are mutually linked by 5′-3′-phosphodiester bonds.










Abbreviationa
Nucleotide(s)







A
adenosine-5′-phosphate



C
cytidine-5′-phosphate



G
guanosine-5′-phosphate



T, dT
2′-deoxy-thymidine-5′-phosphate



U
uridine-5′-phosphate



N
any nucleotide (G, A, C, or T)



a
2′-O-methyladenosine-5′-phosphate



c
2′-O-methylcytidine-5′-phosphate



g
2′-O-methylguanosine-5′-phosphate



u
2′-O-methyluridine-5′-phosphate



sT, sdT
2′-deoxy-thymidine-5′phosphate-phosphorothioate










Source of Reagents
Where the source of a reagent is not specifically given herein, such reagent may be obtained from any supplier of reagents for molecular biology at a quality/purity standard for application in molecular biology.
siRNA Synthesis
Single-stranded RNAs can be produced by solid phase synthesis on a scale of 1 mmole using an Expedite 8909 synthesizer (Applied Biosystems, Applera Deutschland GmbH, Darmstadt, Germany) and controlled pore glass (CPG, 500 Å, Proligo Biochemie GmbH, Hamburg, Germany) as solid support. RNA and RNA containing 2′-O-methyl nucleotides can be generated by solid phase synthesis employing the corresponding phosphoramidites and 2′-O-methyl phosphoramidites, respectively (Proligo Biochemie GmbH, Hamburg, Germany). These building blocks can be incorporated at selected sites within the sequence of the oligoribonucleotide chain using standard nucleoside phosphoramidite chemistry such as described in Current protocols in nucleic acid chemistry, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA. Phosphorothioate linkages can be introduced by replacement of the iodine oxidizer solution with a solution of the Beaucage reagent (Chruachem Ltd, Glasgow, UK) in acetonitrile (1%). Further ancillary reagents can be obtained from Mallinckrodt Baker (Griesheim, Germany).
Deprotection and purification of the crude oligoribonucleotides by anion exchange HPLC can be carried out according to established procedures. Yields and concentrations can be determined by UV absorption of a solution of the respective RNA at a wavelength of 260 nm using a spectral photometer (DU 640B, Beckman Coulter GmbH, Unterschleiβheim, Germany). Double stranded RNA can be generated by mixing an equimolar solution of complementary strands in annealing buffer (20 mM sodium phosphate, pH 6.8; 100 mM sodium chloride), heated in a water bath at 85-90° C. for 3 minutes and cooled to room temperature over a period of 3-4 hours. The annealed RNA solution can be stored at −20° C. until use.
For the synthesis of 3′-cholesterol-conjugated siRNAs (herein referred to as -Chol-3′), an appropriately modified solid support can be used for RNA synthesis. The modified solid support was prepared as follows:
Diethyl-2-azabutane-1,4-dicarboxylate AA




A 4.7 M aqueous solution of sodium hydroxide (50 mL) can be added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) can be added and the mixture can be stirred at room temperature until completion of the reaction can be ascertained by TLC. After 19 h the solution can be partitioned with dichloromethane (3×100 mL). The organic layer can be dried with anhydrous sodium sulfate, filtered and evaporated. The residue can be distilled to afford AA (28.8 g, 61%).
3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonyl-amino)-hexanoyl]-amino}-propionic acid ethyl ester AB




Fmoc-6-amino-hexanoic acid (9.12 g, 25.83 mmol) can be dissolved in dichloromethane (50 mL) and cooled with ice. Diisopropylcarbodiimde (3.25 g, 3.99 mL, 25.83 mmol) can be added to the solution at 0° C. It can then be followed by the addition of Diethyl-azabutane-1,4-dicarboxylate (5 g, 24.6 mmol) and dimethylamino pyridine (0.305 g, 2.5 mmol). The solution can be brought to room temperature and stirred further for 6 h. Completion of the reaction was ascertained by TLC. The reaction mixture can be concentrated under vacuum and ethyl acetate can be added to precipitate diisopropyl urea. The suspension can be filtered. The filtrate can be washed with 5% aqueous hydrochloric acid, 5% sodium bicarbonate and water. The combined organic layer can be dried over sodium sulfate and concentrated to give the crude product which can be purified by column chromatography (50% EtOAC/Hexanes) to yield 11.87 g (88%) of AB.
3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC




3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) can be dissolved in 20% piperidine in dimethylformamide at 0° C. The solution can be stirred continuously for 1 h. The reaction mixture can be concentrated under vacuum, water can be added to the residue, and the product can be extracted with ethyl acetate. The crude product can be purified by conversion into its hydrochloride salt.
3-({6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}ethoxycarbonylmethyl-amino)-propionic acid ethyl ester AD




The hydrochloride salt of 3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC (4.7 g, 14.8 mmol) can be taken up in dichloromethane. The suspension was cooled to 0° C. on ice. To the suspension diisopropylethylamine (3.87 g, 5.2 mL, 30 mmol) can be added. To the resulting solution cholesteryl chloroformate (6.675 g, 14.8 mmol) can be added. The reaction mixture can be stirred overnight. The reaction mixture can be diluted with dichloromethane and washed with 10% hydrochloric acid. The product can be purified by flash chromatography (10.3 g, 92%).
1-{6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester AE




Potassium t-butoxide (1.1 g, 9.8 mmol) can be slurried in 30 mL of dry toluene. The mixture can be cooled to 0° C. on ice and 5 g (6.6 mmol) of diester AD can be added slowly with stirring within 20 mins. The temperature can be kept below 5° C. during the addition. The stirring can be continued for 30 mins at 0° C. and 1 mL of glacial acetic acid can be added, immediately followed by 4 g of NaH2PO4.H2O in 40 mL of water. The resultant mixture can be extracted twice with 100 mL of dichloromethane each and the combined organic extracts can be washed twice with 10 mL of phosphate buffer each, dried, and evaporated to dryness. The residue can be dissolved in 60 mL of toluene, cooled to 0° C. and extracted with three 50 mL portions of cold pH 9.5 carbonate buffer. The aqueous extracts can be adjusted to pH 3 with phosphoric acid, and extracted with five 40 mL portions of chloroform which can be combined, dried and evaporated to dryness. The residue can be purified by column chromatography using 25% ethylacetate/hexane to afford 1.9 g of b-ketoester (39%).
[6-(3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-yl)-6-oxo-hexyl]-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AF




Methanol (2 mL) can be added dropwise over a period of 1 h to a refluxing mixture of b-ketoester AE (1.5 g, 2.2 mmol) and sodium borohydride (0.226 g, 6 mmol) in tetrahydrofuran (10 mL). Stirring can be continued at reflux temperature for 1 h. After cooling to room temperature, 1 N HCl (12.5 mL) can be added, the mixture was extracted with ethylacetate (3×40 mL). The combined ethylacetate layer can be dried over anhydrous sodium sulfate and concentrated under vacuum to yield the product which can be purified by column chromatography (10% MeOH/CHCl3) (89%).
(6-{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-6-oxo-hexyl)-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AG




Diol AF (1.25 gm 1.994 mmol) can be dried by evaporating with pyridine (2×5 mL) in vacuo. Anhydrous pyridine (10 mL) and 4,4′-dimethoxytritylchloride (0.724 g, 2.13 mmol) can be added with stirring. The reaction can be carried out at room temperature overnight. The reaction can be quenched by the addition of methanol. The reaction mixture can be concentrated under vacuum and to the residue dichloromethane (50 mL) was added. The organic layer can be washed with 1M aqueous sodium bicarbonate. The organic layer can be dried over anhydrous sodium sulfate, filtered and concentrated. The residual pyridine can be removed by evaporating with toluene. The crude product can be purified by column chromatography (2% MeOH/Chloroform, Rf=0.5 in 5% MeOH/CHCl3) (1.75 g, 95%).
Succinic acid mono-(4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-{6-[17-(1,5-dimethyl-hexyl)-10,13-dimethyl 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}-pyrrolidin-3-yl)ester AH




Compound AG (1.0 g, 1.05 mmol) can be mixed with succinic anhydride (0.150 g, 1.5 mmol) and DMAP (0.073 g, 0.6 mmol) and dried in a vacuum at 40° C. overnight. The mixture can be dissolved in anhydrous dichloroethane (3 mL), triethylamine (0.318 g, 0.440 mL, 3.15 mmol) can be added and the solution can be stirred at room temperature under argon atmosphere for 16 h. It can then be diluted with dichloromethane (40 mL) and washed with ice cold aqueous citric acid (5 wt %, 30 mL) and water (2×20 mL). The organic phase can be dried over anhydrous sodium sulfate and concentrated to dryness. The residue can be used as such for the next step.
Cholesterol Derivatised CPG AI




Succinate AH (0.254 g, 0.242 mmol) can be dissolved in a mixture of dichloromethane/acetonitrile (3:2, 3 mL). To that solution DMAP (0.0296 g, 0.242 mmol) in acetonitrile (1.25 mL), 2,2′-Dithio-bis(5-nitropyridine) (0.075 g, 0.242 mmol) in acetonitrile/dichloroethane (3:1, 1.25 mL) can be added successively. To the resulting solution triphenylphosphine (0.064 g, 0.242 mmol) in acetonitrile (0.6 ml) was added. The reaction mixture can turn bright orange in color. The solution can be agitated briefly using a wrist-action shaker (5 mins). Long chain alkyl amine-CPG (LCAA-CPG) (1.5 g, 61 mM) can be added. The suspension can be agitated for 2 h. The CPG was filtered through a sintered funnel and washed with acetonitrile, dichloromethane and ether successively. Unreacted amino groups can be masked using acetic anhydride/pyridine. The achieved loading of the CPG can be measured by taking UV measurement (37 mM/g).
The synthesis of siRNAs bearing a 5′-12-dodecanoic acid bisdecylamide group (herein referred to as “5′-C32-”) or a 5′-cholesteryl derivative group (herein referred to as “5′-Chol-”) can be performed as described in WO 2004/065601, except that, for the cholesteryl derivative, the oxidation step can be performed using the Beaucage reagent in order to introduce a phosphorothioate linkage at the 5′-end of the nucleic acid oligomer.
Example 2
In Vitro Screen of GSK3α and GSK3β siRNAs Against Endogenous GSK3α and GSK3β mRNA Expression in Mouse HT22 Cells
Mouse HT22 cells were a gift from Dr. Marcy MacDonald and cultured in Dulbecco's modified Eagle's medium supplied with 10% fetal bovine serum and differentiated in modified serum-free medium (Dulbecco's modified Eagle's medium, N2 supplement, 50 ng/ml nerve growth factor-β, 100 μM phorbol 12,13-dibutyrate, 100 μM dibutyryl cAMP) for 24-48 h before treatment. All treatments were performed in differentiation medium with reduced nerve growth factor-β content (5 ng/ml) at 37° C. in a humidified incubator with 5% CO2.
Cells were transfected with the modified siRNAtargeting mouse GSK3α or GSK3β described in Table 4 and Table 5. For transfection with siRNA, HT22 cells were seeded at a density of 1.0×105 cells/well in 6-well tissue culture plates and transfected directly. Transfection of siRNA (37.5 nM for single dose screen) was carried out with Lipofectamine-2000 (Invitrogen, Carlsbad, Calif.) as described by the manufacturer. For dose-response curves, siRNA concentrations ranged from 10 nM to 0.1 nM in 10-fold dilutions.
24 hours after transfection, HT22 cells were lysed and cDNA was generated for GSK3α or GSK3β and GAPDH mRNA quantitation. GSK3α or GSK3β mRNA levels were normalized to GAPDH mRNA levels. For each siRNA, 2 individual data points were collected. An siRNA duplex unrelated to the GSK3α or GSK3β gene was used as a control. The activity of a given GSK3α- or GSK3β-specific siRNA duplex was expressed as the fraction of the GSK3α or GSK3β mRNA level in treated cells relative to the GSK3α or GSK3β mRNA level in cells treated with the control siRNA duplex.
Duplex identifier used in the Figures and in Examples 2-5 refer to the modified version of the duplex, e.g., AD-18821 as used in the Figures and Examples 2-5 refers to the modified version of AD-18821, e.g., AD-18821-b1.
FIG. 1 and FIG. 2 provide the results from the in vitro HT22 screen where the siRNAs were tested at a single dose of 37.5 nM. The fraction of GSK3α and GSK3β mRNA remaining in treated cells compared to controls, ±standard deviation, is shown. A number of GSK3α siRNAs (AD-18821, AD-18825 or AD-18832) at 37.5 nM were effective at reducing GSK3α mRNA levels by more than 40%, without affecting GSK3β mRNA levels, in HT22 cells. A number of GSK3β siRNAs (AD-18833, AD-18834, AD-18836, AD-18837, AD-18838, AD-18841, AD-18842, AD-18843 or AD-18844) at 37.5 nM were effective at reducing GSK3 β mRNA levels by more than 40%, without affecting GSK3α mRNA levels, in HT22 cells.
FIG. 3 and FIG. 4 show the dose-dependence of selected siRNAs on mRNA reduction in HT22 cells. Several siRNAs targeting GSK3α (AD-18821, AD-18825 or AD-18826) exhibited IC50 values of less than or equal to 1-10 nM in suppressing GSK3α mRNA after transfection into HT22 cells (FIG. 3). Several siRNAs targeting GSK3β (AD-18838 or AD-18843) exhibited IC50 values of less than 1 nM in suppressing GSK3β mRNA (FIG. 4).
Example 3
GSK3β dsRNAs Reduce Endogenous GSK3β Protein in HT22 Cells
HT22 cells were cultured and transfected as previously described with 75 nM of 11 siRNAs against GSK3β (AD-18833, AD-18834, AD-18835, AD-18836, AD-18837, AD-18838, AD-18839, AD-18841, AD-18842, AD-18843 or AD-18844); one control unrelated siRNA (AD-1955) or Lipofectamine-2000 alone (Control). 48 hours post-transfection, the cells were harvested and lysed. Proteins in the lysates were separated on a denaturing polyacrylamide gel. GSK3β and β-actin were detected by standard western blot protocols using antibodies that bind to the proteins. For GSK3β detection, the membrane was probed with a monoclonal GSK3β antibody produced in rabbit (Cell Signaling, Danvers, Mass.) followed by a secondary antibody donkey anti-rabbit IgG horseradish peroxidase (GE Healthcare, Piscataway, N.J.). β-actin was detected by mouse anti-actin antibody (Sigma, St. Louis, Mo.) followed by a Sheep anti-mouse IgG horseradish peroxidase secondary antibody (GE Healthcare, Piscataway, N.J.).
FIG. 5 provides the results. AD-18838, AD-18843 and AD-18844, all at 75 nM, decreased the level of GSK3β protein relative to the control protein β-actin, whereas the control unrelated siRNA had no effect on the level of GSK3β protein. These results demonstrate that dsRNAs targeting GSK3β effectively reduce not only GSK3β mRNA levels, but also GSK3β protein levels.
Example 4
In Vivo Down-Modulation of Endogenous GSK3α or GSK3β mRNA Levels by CNS Administration of GSK3α or GSK3β dsRNAs in Mice
To assess the biological activity of GSK3 dsRNAs in vivo, dsRNAs targeting GSK3α (AD-18821, AD-18825, and AD-18826) or GSK3β (AD-18838, AD-18843, and AD-18844) were evaluated.
In mice, 1.26 mg AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, AD-18844, or phosphate-buffered saline (PBS, vehicle control) was administered by continuous infusion into the nucleus accumbens over 14 days. Ten week old male C57BL6 mice (Charles River Laboratory) received stereotaxic implantations of 30-gauge infusion cannulae (Plastics One, Roanok, Va.) such that unilateral infusions were targeted to the nucleus accumbens (anteroposterior+1.1 mm, mediolateral+1.3 mm, relative to bregma; dorsoventral 4.5 mm, relative to skull surface). Mini-osmotic pumps (model 1002) were primed overnight according to the manufacturer's specifications, implanted subcutaneously, and connected via catheters, to deliver (6 mice per treatment group) PBS, 1.1 mM (15 mg/mL) of GSK3α siRNAs (AD-18821, AD-18825, or AD-18826) or 1.1 mM (15 mg/mL) of GSK3β siRNAs (AD-18838, AD-18843, or AD-18844) at 0.25 μL/hr over 14 days. At the end of the 14 day infusion period, animals were sacrificed, brains were removed, and 1.2 mm punches from the ipsilateral nucleus accumbens encompassing the infusion site, from 1 mm thick coronal brain slabs, were flash frozen and stored at −80° C. Individual brain punches from each mouse were quantified for GSK3α and GSK3β mRNA. Each brain punch was run in triplicate for RT-qPCR. Approximately 60 ng of total RNA in a 20 μl total reaction volume was used for RT-qPCR. GSK3α and GSK3β primers were custom designed and obtained from IDT (Integrated DNA Technologies, Inc., Coralville, Iowa). RT-qPCR was run with SBYR. GAPDH was used as the internal control for normalization. Relative expression of GSK3α and GSK3β mRNA was quantified by 2ΔCt (where ΔCt=Ctgene−CtGAPDH).
The GSK3β siRNAs, AD-18844, AD-18838 or AD-18843, showed 53% (ANOVA; p=0.012) (FIG. 6), 28% or 25% GSK3β mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3β siRNA, AD-18844, had no effect on GSK3α mRNA levels. The GSK3α siRNAs, AD-18826, AD-18825 or AD-18821, showed 51% (p=0.052; Tukey Post-hoc ANOVA) (FIG. 7), 42% (t-test; p=0.004) or 15% GSK3α mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3α siRNA, AD-18826, had no effect on GSK3β mRNA levels.
These results demonstrate that infusion into the nucleus accumbens of AD-18844 and AD-18826 are efficacious in vivo in specifically down-modulating GSK3β and GSK3α mRNA levels, respectively, in the nucleus accumbens.
Example 5
Inhibition of GSK-3 Expression in Human Cells
A set of siRNA targeting human GSK3α and GSK3β (Table 6 and Table 7) are evaluated for inhibition of GSK-3 expression in human cell lines. Human cell lines expressing endogenouseGSK3 are transfected with at least one of the duplexes in Table 6 or Table 7, e.g., huGSKA-3 (orthologous to AD-18826-b1) and/or huGSKB-11 (orthologous to AD-18826-b1). The human duplexes can be modified in a similar manner to the mouse duplexes. The transfected cells are assayed for effects on mRNA and protein levels using techniques described herein and known to one of skill in the art.
Example 6
Inhibition of GSK-3 Expression in Humans
A human subject is treated with a pharmaceutical composition comprising a pharmaceutical formulation of an siRNA targeting a human GSK-3 gene.
A subject in need of treatment is selected or identified. The subject can be in need of treatment for manic depression, a metabolic disease, a nervous system disorders, or cancer.
At time zero, a suitable first dose of the composition is subcutaneously administered to the subject. The composition is formulated as described herein. After a period of time, the subject's condition is evaluated, e.g., by measurement episodes of mania, episodes of depression, and the like. This measurement can be accompanied by a measurement of GSK-3 expression in said subject, and/or the products of the successful siRNA-targeting of GSK-3. Other relevant criteria can also be measured. The number and strength of doses are adjusted according to the subject's needs.
After treatment, the subject's condition is compared to the condition existing prior to the treatment, or relative to the condition of a similarly afflicted but untreated subject.







TABLE 1







Sequences of duplexes targeting Mouse GSK3-alpha


Sequences of possible duplexes targeting mouse GSK3-alpha.


Target sequence location identifies target sequence in mouse


GSK3-alpha mRNA NM_001031667.1. Unmodified sense


strand is identical to target sequence. Unmodified a antisense


strand is complementary to target sequence.












Target
SEQ

SEQ




sequence
ID
Unmodified sequence
ID
Modified sequence


location
NO:
5′ to 3′
NO:
5′ to 3′
Strand















670-689
1
AACUGCAGAUUAUGCGUAA
2
AAcuGcAGAuuAuGcGuAAdTsdT
sense


 


670-689
3
UUACGCAUAAUCUGCAGUU
4
UuACGcAuAAUCUGcAGUUdTsdT
antis


 


1074-1093
5
ACAGAUUACACCUCGUCCA
6
AcAGAuuAcAccucGuccAdTsdT
sense


 


1074-1093
7
UGGACGAGGUGUAAUCUGU
8
UGGACGAGGUGuAAUCUGUdTsdT
antis


 


330-349
9
GGCGGCGGGAAAGCGUCAG
10
GGcGGcGGGAAAGcGucAGdTsdT
sense


 


330-349
11
CUGACGCUUUCCCGCCGCC
12
CUGACGCUUUCCCGCCGCCdTsdT
antis


 


239-258
13
GGCGCGGACCAGCUCGUUC
14
GGcGcGGAccAGcucGuucdTsdT
sense


 


239-258
15
GAACGAGCUGGUCCGCGCC
16
GAACGAGCUGGUCCGCGCCdTsdT
antis


 


1340-1359
17
CCUACUGGAGUACACGCCA
18
ccuAcuGGAGuAcAcGccAdTsdT
sense


 


1340-1359
19
UGGCGUGUACUCCAGUAGG
20
UGGCGUGuACUCcAGuAGGdTsdT
antis


 


1342-1361
21
UACUGGAGUACACGCCAUC
22
uAcuGGAGuAcAcGccAucdTsdT
sense


 


1342-1361
23
GAUGGCGUGUACUCCAGUA
24
GAUGGCGUGuACUCcAGuAdTsdT
antis


 


1073-1092
25
CACAGAUUACACCUCGUCC
26
cAcAGAuuAcAccucGuccdTsdT
sense


 


1073-1092
27
GGACGAGGUGUAAUCUGUG
28
GGACGAGGUGuAAUCUGUGdTsdT
antis


 


1236-1255
29
CCUAACUAUACGGAGUUCA
30
ccuAAcuAuAcGGAGuucAdTsdT
sense


 


1236-1255
31
UGAACUCCGUAUAGUUAGG
32
UGAACUCCGuAuAGUuAGGdTsdT
antis


 


435-454
33
GCGGGCACUAGCUUCCCGC
34
GcGGGcAcuAGcuucccGcdTsdT
sense


 


435-454
35
GCGGGAAGCUAGUGCCCGC
36
GCGGGAAGCuAGUGCCCGCdTsdT
antis


 


1231-1250
37
UGAACCCUAACUAUACGGA
38
uGAAcccuAAcuAuAcGGAdTsdT
sense


 


1231-1250
39
UCCGUAUAGUUAGGGUUCA
40
UCCGuAuAGUuAGGGUUcAdTsdT
antis


 


1234-1253
41
ACCCUAACUAUACGGAGUU
42
AcccuAAcuAuAcGGAGuudTsdT
sense


 


1234-1253
43
AACUCCGUAUAGUUAGGGU
44
AACUCCGuAuAGUuAGGGUdTsdT
antis


 


1235-1254
45
CCCUAACUAUACGGAGUUC
46
cccuAAcuAuAcGGAGuucdTsdT
sense


 


1235-1254
47
GAACUCCGUAUAGUUAGGG
48
GAACUCCGuAuAGUuAGGGdTsdT
antis


 


1233-1252
49
AACCCUAACUAUACGGAGU
50
AAcccuAAcuAuAcGGAGudTsdT
sense


 


1233-1252
51
ACUCCGUAUAGUUAGGGUU
52
ACUCCGuAuAGUuAGGGUUdTsdT
antis


 


2027-2046
53
GCCCCCUGGGUGUAAAUAG
54
GcccccuGGGuGuAAAuAGdTsdT
sense


 


2027-2046
55
CUAUUUACACCCAGGGGGC
56
CuAUUuAcACCcAGGGGGCdTsdT
antis


 


 5-24
57
UGACAACGAAGCCGACGGC
58
uGAcAAcGAAGccGAcGGcdTsdT
sense


 


 5-24
59
GCCGUCGGCUUCGUUGUCA
60
GCCGUCGGCUUCGUUGUcAdTsdT
antis


 


1071-1090
61
GCCACAGAUUACACCUCGU
62
GccAcAGAuuAcAccucGudTsdT
sense


 


1071-1090
63
ACGAGGUGUAAUCUGUGGC
64
ACGAGGUGuAAUCUGUGGCdTsdT
antis


 


2000-2019
65
AGCCCAUCUCUCGUCUUCC
66
AGcccAucucucGucuuccdTsdT
sense


 


2000-2019
67
GGAAGACGAGAGAUGGGCU
68
GGAAGACGAGAGAUGGGCUdTsdT
antis


 


 4-23
69
GUGACAACGAAGCCGACGG
70
GuGAcAAcGAAGccGAcGGdTsdT
sense


 


 4-23
71
CCGUCGGCUUCGUUGUCAC
72
CCGUCGGCUUCGUUGUcACdTsdT
antis


 


1085-1104
73
CUCGUCCAUCGAUGUGUGG
74
cucGuccAucGAuGuGuGGdTsdT
sense


 


1085-1104
75
CCACACAUCGAUGGACGAG
76
CcAcAcAUCGAUGGACGAGdTsdT
antis


 


2070-2089
77
AAACGUCAAUUCACACCAU
78
AAAcGucAAuucAcAccAudTsdT
sense


 


2070-2089
79
AUGGUGUGAAUUGACGUUU
80
AUGGUGUGAAUUGACGUUUdTsdT
antis


 


2072-2091
81
ACGUCAAUUCACACCAUUC
82
AcGucAAuucAcAccAuucdTsdT
sense


 


2072-2091
83
GAAUGGUGUGAAUUGACGU
84
GAAUGGUGUGAAUUGACGUdTsdT
antis


 


251-270
85
CUCGUUCGCGGAGCCAGGA
86
cucGuucGcGGAGccAGGAdTsdT
sense


 


251-270
87
UCCUGGCUCCGCGAACGAG
88
UCCUGGCUCCGCGAACGAGdTsdT
antis


 


241-260
89
CGCGGACCAGCUCGUUCGC
90
cGcGGAccAGcucGuucGcdTsdT
sense


 


241-260
91
GCGAACGAGCUGGUCCGCG
92
GCGAACGAGCUGGUCCGCGdTsdT
antis


 


581-600
93
CGGAGUAGUAUACCAGGCA
94
cGGAGuAGuAuAccAGGcAdTsdT
sense


 


581-600
95
UGCCUGGUAUACUACUCCG
96
UGCCUGGuAuACuACUCCGdTsdT
antis


 


1076-1095
97
AGAUUACACCUCGUCCAUC
98
AGAuuAcAccucGuccAucdTsdT
sense


 


1076-1095
99
GAUGGACGAGGUGUAAUCU
100
GAUGGACGAGGUGuAAUCUdTsdT
antis


 


2069-2088
101
AAAACGUCAAUUCACACCA
102
AAAAcGucAAuucAcAccAdTsdT
sense


 


2069-2088
103
UGGUGUGAAUUGACGUUUU
104
UGGUGUGAAUUGACGUUUUdTsdT
antis


 


 6-25
105
GACAACGAAGCCGACGGCA
106
GAcAAcGAAGccGAcGGcAdTsdT
sense


 


 6-25
107
UGCCGUCGGCUUCGUUGUC
108
UGCCGUCGGCUUCGUUGUCdTsdT
antis


 


16-35
109
CCGACGGCAGAGGGACUUC
110
ccGAcGGcAGAGGGAcuucdTsdT
sense


 


16-35
111
GAAGUCCCUCUGCCGUCGG
112
GAAGUCCCUCUGCCGUCGGdTsdT
antis


 


243-262
113
CGGACCAGCUCGUUCGCGG
114
cGGAccAGcucGuucGcGGdTsdT
sense


 


243-262
115
CCGCGAACGAGCUGGUCCG
116
CCGCGAACGAGCUGGUCCGdTsdT
antis


 


244-263
117
GGACCAGCUCGUUCGCGGA
118
GGAccAGcucGuucGcGGAdTsdT
sense


 


244-263
119
UCCGCGAACGAGCUGGUCC
120
UCCGCGAACGAGCUGGUCCdTsdT
antis


 


328-347
121
CUGGCGGCGGGAAAGCGUC
122
cuGGcGGcGGGAAAGcGucdTsdT
sense


 


328-347
123
GACGCUUUCCCGCCGCCAG
124
GACGCUUUCCCGCCGCcAGdTsdT
antis


 


331-350
125
GCGGCGGGAAAGCGUCAGU
126
GcGGcGGGAAAGcGucAGudTsdT
sense


 


331-350
127
ACUGACGCUUUCCCGCCGC
128
ACUGACGCUUUCCCGCCGCdTsdT
antis


 


340-359
129
AAGCGUCAGUCGGGGCUAU
130
AAGcGucAGucGGGGcuAudTsdT
sense


 


340-359
131
AUAGCCCCGACUGACGCUU
132
AuAGCCCCGACUGACGCUUdTsdT
antis


 


432-451
133
GGCGCGGGCACUAGCUUCC
134
GGcGcGGGcAcuAGcuuccdTsdT
sense


 


432-451
135
GGAAGCUAGUGCCCGCGCC
136
GGAAGCuAGUGCCCGCGCCdTsdT
antis


 


655-674
137
GGUUCAAGAACCGAGAACU
138
GGuucAAGAAccGAGAAcudTsdT
sense


 


655-674
139
AGUUCUCGGUUCUUGAACC
140
AGUUCUCGGUUCUUGAACCdTsdT
antis


 


1024-1043
141
CCUACAUCUGCUCUCGGUA
142
ccuAcAucuGcucucGGuAdTsdT
sense


 


1024-1043
143
UACCGAGAGCAGAUGUAGG
144
uACCGAGAGcAGAUGuAGGdTsdT
antis


 


1075-1094
145
CAGAUUACACCUCGUCCAU
146
cAGAuuAcAccucGuccAudTsdT
sense


 


1075-1094
147
AUGGACGAGGUGUAAUCUG
148
AUGGACGAGGUGuAAUCUGdTsdT
antis


 


1089-1108
149
UCCAUCGAUGUGUGGUCGG
150
uccAucGAuGuGuGGucGGdTsdT
sense


 


1089-1108
151
CCGACCACACAUCGAUGGA
152
CCGACcAcAcAUCGAUGGAdTsdT
antis


 


1090-1109
153
CCAUCGAUGUGUGGUCGGC
154
ccAucGAuGuGuGGucGGcdTsdT
sense


 


1090-1109
155
GCCGACCACACAUCGAUGG
156
GCCGACcAcAcAUCGAUGGdTsdT
antis


 


1092-1111
157
AUCGAUGUGUGGUCGGCUG
158
AucGAuGuGuGGucGGcuGdTsdT
sense


 


1092-1111
159
CAGCCGACCACACAUCGAU
160
cAGCCGACcAcAcAUCGAUdTsdT
antis


 


1093-1112
161
UCGAUGUGUGGUCGGCUGG
162
ucGAuGuGuGGucGGcuGGdTsdT
sense


 


1093-1112
163
CCAGCCGACCACACAUCGA
164
CcAGCCGACcAcAcAUCGAdTsdT
antis


 


1230-1249
165
AUGAACCCUAACUAUACGG
166
AuGAAcccuAAcuAuAcGGdTsdT
sense


 


1230-1249
167
CCGUAUAGUUAGGGUUCAU
168
CCGuAuAGUuAGGGUUcAUdTsdT
antis


 


1348-1367
169
AGUACACGCCAUCCUCAAG
170
AGuAcAcGccAuccucAAGdTsdT
sense


 


1348-1367
171
CUUGAGGAUGGCGUGUACU
172
CUUGAGGAUGGCGUGuACUdTsdT
antis


 


1401-1420
173
UUCGAUGAACUGCGGAGAC
174
uucGAuGAAcuGcGGAGAcdTsdT
sense


 


1401-1420
175
GUCUCCGCAGUUCAUCGAA
176
GUCUCCGcAGUUcAUCGAAdTsdT
antis


 


1402-1421
177
UCGAUGAACUGCGGAGACU
178
ucGAuGAAcuGcGGAGAcudTsdT
sense


 


1402-1421
179
AGUCUCCGCAGUUCAUCGA
180
AGUCUCCGcAGUUcAUCGAdTsdT
antis


 


1489-1508
181
UCCAACCAUCUCUCAAUGC
182
uccAAccAucucucAAuGcdTsdT
sense


 


1489-1508
183
GCAUUGAGAGAUGGUUGGA
184
GcAUUGAGAGAUGGUUGGAdTsdT
antis


 


1999-2018
185
CAGCCCAUCUCUCGUCUUC
186
cAGcccAucucucGucuucdTsdT
sense


 


1999-2018
187
GAAGACGAGAGAUGGGCUG
188
GAAGACGAGAGAUGGGCUGdTsdT
antis


 


2028-2047
189
CCCCCUGGGUGUAAAUAGA
190
cccccuGGGuGuAAAuAGAdTsdT
sense


 


2028-2047
191
UCUAUUUACACCCAGGGGG
192
UCuAUUuAcACCcAGGGGGdTsdT
antis


 


2068-2087
193
GAAAACGUCAAUUCACACC
194
GAAAAcGucAAuucAcAccdTsdT
sense


 


2068-2087
195
GGUGUGAAUUGACGUUUUC
196
GGUGUGAAUUGACGUUUUCdTsdT
antis


 


2080-2099
197
UCACACCAUUCAACUUGCC
198
ucAcAccAuucAAcuuGccdTsdT
sense


 


2080-2099
199
GGCAAGUUGAAUGGUGUGA
200
GGcAAGUUGAAUGGUGUGAdTsdT
antis


 


2083-2102
201
CACCAUUCAACUUGCCCCC
202
cAccAuucAAcuuGcccccdTsdT
sense


 


2083-2102
203
GGGGGCAAGUUGAAUGGUG
204
GGGGGcAAGUUGAAUGGUGdTsdT
antis


 


2084-2103
205
ACCAUUCAACUUGCCCCCC
206
AccAuucAAcuuGccccccdTsdT
sense


 


2084-2103
207
GGGGGGCAAGUUGAAUGGU
208
GGGGGGcAAGUUGAAUGGUdTsdT
antis


 


2086-2105
209
CAUUCAACUUGCCCCCCCC
210
cAuucAAcuuGccccccccdTsdT
sense


 


2086-2105
211
GGGGGGGGCAAGUUGAAUG
212
GGGGGGGGcAAGUUGAAUGdTsdT
antis


 


2244-2263
213
UUGGCAUGAAACCCUUAAA
214
uuGGcAuGAAAcccuuAAAdTsdT
sense


 


2244-2263
215
UUUAAGGGUUUCAUGCCAA
216
UUuAAGGGUUUcAUGCcAAdTsdT
antis


 


71-90
217
AGCCGGAGCCCGAACGGCG
218
AGccGGAGcccGAAcGGcGdTsdT
sense


 


71-90
219
CGCCGUUCGGGCUCCGGCU
220
CGCCGUUCGGGCUCCGGCUdTsdT
antis


 


177-196
221
CCUGCGCUCGGCGCCAUGA
222
ccuGcGcucGGcGccAuGAdTsdT
sense


 


177-196
223
UCAUGGCGCCGAGCGCAGG
224
UcAUGGCGCCGAGCGcAGGdTsdT
antis


 


836-855
225
CACCCCUAUCAUCUACAUC
226
cAccccuAucAucuAcAucdTsdT
sense


 


836-855
227
GAUGUAGAUGAUAGGGGUG
228
GAUGuAGAUGAuAGGGGUGdTsdT
antis


 


929-948
229
GCCCCAGAAUUUGCUUGUG
230
GccccAGAAuuuGcuuGuGdTsdT
sense


 


929-948
231
CACAAGCAAAUUCUGGGGC
232
cAcAAGcAAAUUCUGGGGCdTsdT
antis


 


1001-1020
233
GGUUCGGGGGGAGCCCAAU
234
GGuucGGGGGGAGcccAAudTsdT
sense


 


1001-1020
235
AUUGGGCUCCCCCCGAACC
236
AUUGGGCUCCCCCCGAACCdTsdT
antis


 


1091-1110
237
CAUCGAUGUGUGGUCGGCU
238
cAucGAuGuGuGGucGGcudTsdT
sense


 


1091-1110
239
AGCCGACCACACAUCGAUG
240
AGCCGACcAcAcAUCGAUGdTsdT
antis


 


1328-1347
241
ACUCUGCUCUAGCCUACUG
242
AcucuGcucuAGccuAcuGdTsdT
sense


 


1328-1347
243
CAGUAGGCUAGAGCAGAGU
244
cAGuAGGCuAGAGcAGAGUdTsdT
antis


 


1338-1357
245
AGCCUACUGGAGUACACGC
246
AGccuAcuGGAGuAcAcGcdTsdT
sense


 


1338-1357
247
GCGUGUACUCCAGUAGGCU
248
GCGUGuACUCcAGuAGGCUdTsdT
antis


 


1339-1358
249
GCCUACUGGAGUACACGCC
250
GccuAcuGGAGuAcAcGccdTsdT
sense


 


1339-1358
251
GGCGUGUACUCCAGUAGGC
252
GGCGUGuACUCcAGuAGGCdTsdT
antis


 


2059-2078
253
UUUCUUAAAGAAAACGUCA
254
uuucuuAAAGAAAAcGucAdTsdT
sense


 


2059-2078
255
UGACGUUUUCUUUAAGAAA
256
UGACGUUUUCUUuAAGAAAdTsdT
antis


 


2067-2086
257
AGAAAACGUCAAUUCACAC
258
AGAAAAcGucAAuucAcAcdTsdT
sense


 


2067-2086
259
GUGUGAAUUGACGUUUUCU
260
GUGUGAAUUGACGUUUUCUdTsdT
antis


 


2076-2095
261
CAAUUCACACCAUUCAACU
262
cAAuucAcAccAuucAAcudTsdT
sense


 


2076-2095
263
AGUUGAAUGGUGUGAAUUG
264
AGUUGAAUGGUGUGAAUUGdTsdT
antis


 


2089-2108
265
UCAACUUGCCCCCCCCAGC
266
ucAAcuuGccccccccAGcdTsdT
sense


 


2089-2108
267
GCUGGGGGGGGCAAGUUGA
268
GCUGGGGGGGGcAAGUUGAdTsdT
antis


 


2231-2250
269
GUUCAAUAAAUUAUUGGCA
270
GuucAAuAAAuuAuuGGcAdTsdT
sense


 


2231-2250
271
UGCCAAUAAUUUAUUGAAC
272
UGCcAAuAAUUuAUUGAACdTsdT
antis


 


207-226
273
CCUUCGGGAGGCGGCCCUG
274
ccuucGGGAGGcGGcccuGdTsdT
sense


 


207-226
275
CAGGGCCGCCUCCCGAAGG
276
cAGGGCCGCCUCCCGAAGGdTsdT
antis


 


240-259
277
GCGCGGACCAGCUCGUUCG
278
GcGcGGAccAGcucGuucGdTsdT
sense


 


240-259
279
CGAACGAGCUGGUCCGCGC
280
CGAACGAGCUGGUCCGCGCdTsdT
antis


 


242-261
281
GCGGACCAGCUCGUUCGCG
282
GcGGAccAGcucGuucGcGdTsdT
sense


 


242-261
283
CGCGAACGAGCUGGUCCGC
284
CGCGAACGAGCUGGUCCGCdTsdT
antis


 


249-268
285
AGCUCGUUCGCGGAGCCAG
286
AGcucGuucGcGGAGccAGdTsdT
sense


 


249-268
287
CUGGCUCCGCGAACGAGCU
288
CUGGCUCCGCGAACGAGCUdTsdT
antis


 


252-271
289
UCGUUCGCGGAGCCAGGAG
290
ucGuucGcGGAGccAGGAGdTsdT
sense


 


252-271
291
CUCCUGGCUCCGCGAACGA
292
CUCCUGGCUCCGCGAACGAdTsdT
antis


 


324-343
293
GGCACUGGCGGCGGGAAAG
294
GGcAcuGGcGGcGGGAAAGdTsdT
sense


 


324-343
295
CUUUCCCGCCGCCAGUGCC
296
CUUUCCCGCCGCcAGUGCCdTsdT
antis


 


329-348
297
UGGCGGCGGGAAAGCGUCA
298
uGGcGGcGGGAAAGcGucAdTsdT
sense


 


329-348
299
UGACGCUUUCCCGCCGCCA
300
UGACGCUUUCCCGCCGCcAdTsdT
antis


 


427-446
301
GCCCCGGCGCGGGCACUAG
302
GccccGGcGcGGGcAcuAGdTsdT
sense


 


427-446
303
CUAGUGCCCGCGCCGGGGC
304
CuAGUGCCCGCGCCGGGGCdTsdT
antis


 


428-447
305
CCCCGGCGCGGGCACUAGC
306
ccccGGcGcGGGcAcuAGcdTsdT
sense


 


428-447
307
GCUAGUGCCCGCGCCGGGG
308
GCuAGUGCCCGCGCCGGGGdTsdT
antis


 


429-448
309
CCCGGCGCGGGCACUAGCU
310
cccGGcGcGGGcAcuAGcudTsdT
sense


 


429-448
311
AGCUAGUGCCCGCGCCGGG
312
AGCuAGUGCCCGCGCCGGGdTsdT
antis


 


430-449
313
CCGGCGCGGGCACUAGCUU
314
ccGGcGcGGGcAcuAGcuudTsdT
sense


 


430-449
315
AAGCUAGUGCCCGCGCCGG
316
AAGCuAGUGCCCGCGCCGGdTsdT
antis


 


438-457
317
GGCACUAGCUUCCCGCCGC
318
GGcAcuAGcuucccGccGcdTsdT
sense


 


438-457
319
GCGGCGGGAAGCUAGUGCC
320
GCGGCGGGAAGCuAGUGCCdTsdT
antis


 


583-602
321
GAGUAGUAUACCAGGCACG
322
GAGuAGuAuAccAGGcAcGdTsdT
sense


 


583-602
323
CGUGCCUGGUAUACUACUC
324
CGUGCCUGGuAuACuACUCdTsdT
antis


 


654-673
325
AGGUUCAAGAACCGAGAAC
326
AGGuucAAGAAccGAGAAcdTsdT
sense


 


654-673
327
GUUCUCGGUUCUUGAACCU
328
GUUCUCGGUUCUUGAACCUdTsdT
antis


 


667-686
329
GAGAACUGCAGAUUAUGCG
330
GAGAAcuGcAGAuuAuGcGdTsdT
sense


 


667-686
331
CGCAUAAUCUGCAGUUCUC
332
CGcAuAAUCUGcAGUUCUCdTsdT
antis


 


928-947
333
AGCCCCAGAAUUUGCUUGU
334
AGccccAGAAuuuGcuuGudTsdT
sense


 


928-947
335
ACAAGCAAAUUCUGGGGCU
336
AcAAGcAAAUUCUGGGGCUdTsdT
antis


 


 994-1013
337
AGCAGCUGGUUCGGGGGGA
338
AGcAGcuGGuucGGGGGGAdTsdT
sense


 


 994-1013
339
UCCCCCCGAACCAGCUGCU
340
UCCCCCCGAACcAGCUGCUdTsdT
antis


 


1005-1024
341
CGGGGGGAGCCCAAUGUGU
342
cGGGGGGAGcccAAuGuGudTsdT
sense


 


1005-1024
343
ACACAUUGGGCUCCCCCCG
344
AcAcAUUGGGCUCCCCCCGdTsdT
antis


 


1008-1027
345
GGGGAGCCCAAUGUGUCCU
346
GGGGAGcccAAuGuGuccudTsdT
sense


 


1008-1027
347
AGGACACAUUGGGCUCCCC
348
AGGAcAcAUUGGGCUCCCCdTsdT
antis


 


1124-1143
349
UGAGCUACUUCUCGGCCAG
350
uGAGcuAcuucucGGccAGdTsdT
sense


 


1124-1143
351
CUGGCCGAGAAGUAGCUCA
352
CUGGCCGAGAAGuAGCUcAdTsdT
antis


 


1303-1322
353
CAAAGACACCACCUGAGGC
354
cAAAGAcAccAccuGAGGcdTsdT
sense


 


1303-1322
355
GCCUCAGGUGGUGUCUUUG
356
GCCUcAGGUGGUGUCUUUGdTsdT
antis


 


1311-1330
357
CCACCUGAGGCCAUUGCAC
358
ccAccuGAGGccAuuGcAcdTsdT
sense


 


1311-1330
359
GUGCAAUGGCCUCAGGUGG
360
GUGcAAUGGCCUcAGGUGGdTsdT
antis


 


1444-1463
361
GCCCGCUUCCCCCCCUGUU
362
GcccGcuucccccccuGuudTsdT
sense


 


1444-1463
363
AACAGGGGGGGAAGCGGGC
364
AAcAGGGGGGGAAGCGGGCdTsdT
antis


 


1488-1507
365
AUCCAACCAUCUCUCAAUG
366
AuccAAccAucucucAAuGdTsdT
sense


 


1488-1507
367
CAUUGAGAGAUGGUUGGAU
368
cAUUGAGAGAUGGUUGGAUdTsdT
antis


 


1851-1870
369
AUUUUAACUGUUUGUAGGG
370
AuuuuAAcuGuuuGuAGGGdTsdT
sense


 


1851-1870
371
CCCUACAAACAGUUAAAAU
372
CCCuAcAAAcAGUuAAAAUdTsdT
antis


 


1852-1871
373
UUUUAACUGUUUGUAGGGG
374
uuuuAAcuGuuuGuAGGGGdTsdT
sense


 


1852-1871
375
CCCCUACAAACAGUUAAAA
376
CCCCuAcAAAcAGUuAAAAdTsdT
antis


 


1935-1954
377
CUCCCCCAGGCUACCACUC
378
cucccccAGGcuAccAcucdTsdT
sense


 


1935-1954
379
GAGUGGUAGCCUGGGGGAG
380
GAGUGGuAGCCUGGGGGAGdTsdT
antis


 


1975-1994
381
GGUCCCUUGUAAAUAGAAC
382
GGucccuuGuAAAuAGAAcdTsdT
sense


 


1975-1994
383
GUUCUAUUUACAAGGGACC
384
GUUCuAUUuAcAAGGGACCdTsdT
antis


 


2029-2048
385
CCCCUGGGUGUAAAUAGAU
386
ccccuGGGuGuAAAuAGAudTsdT
sense


 


2029-2048
387
AUCUAUUUACACCCAGGGG
388
AUCuAUUuAcACCcAGGGGdTsdT
antis


 


2033-2052
389
UGGGUGUAAAUAGAUUGUU
390
uGGGuGuAAAuAGAuuGuudTsdT
sense


 


2033-2052
391
AACAAUCUAUUUACACCCA
392
AAcAAUCuAUUuAcACCcAdTsdT
antis


 


2062-2081
393
CUUAAAGAAAACGUCAAUU
394
cuuAAAGAAAAcGucAAuudTsdT
sense


 


2062-2081
395
AAUUGACGUUUUCUUUAAG
396
AAUUGACGUUUUCUUuAAGdTsdT
antis


 


2063-2082
397
UUAAAGAAAACGUCAAUUC
398
uuAAAGAAAAcGucAAuucdTsdT
sense


 


2063-2082
399
GAAUUGACGUUUUCUUUAA
400
GAAUUGACGUUUUCUUuAAdTsdT
antis


 


2078-2097
401
AUUCACACCAUUCAACUUG
402
AuucAcAccAuucAAcuuGdTsdT
sense


 


2078-2097
403
CAAGUUGAAUGGUGUGAAU
404
cAAGUUGAAUGGUGUGAAUdTsdT
antis


 


2082-2101
405
ACACCAUUCAACUUGCCCC
406
AcAccAuucAAcuuGccccdTsdT
sense


 


2082-2101
407
GGGGCAAGUUGAAUGGUGU
408
GGGGcAAGUUGAAUGGUGUdTsdT
antis


 


2181-2200
409
UCCCUGGUGUCUUAGUUUC
410
ucccuGGuGucuuAGuuucdTsdT
sense


 


2181-2200
411
GAAACUAAGACACCAGGGA
412
GAAACuAAGAcACcAGGGAdTsdT
antis


 


2197-2216
413
UUCCACAGUAAGGUUUGCC
414
uuccAcAGuAAGGuuuGccdTsdT
sense


 


2197-2216
415
GGCAAACCUUACUGUGGAA
416
GGcAAACCUuACUGUGGAAdTsdT
antis


 


2209-2228
417
GUUUGCCUGUGUACAGACC
418
GuuuGccuGuGuAcAGAccdTsdT
sense


 


2209-2228
419
GGUCUGUACACAGGCAAAC
420
GGUCUGuAcAcAGGcAAACdTsdT
antis


 


2232-2251
421
UUCAAUAAAUUAUUGGCAU
422
uucAAuAAAuuAuuGGcAudTsdT
sense


 


2232-2251
423
AUGCCAAUAAUUUAUUGAA
424
AUGCcAAuAAUUuAUUGAAdTsdT
antis


 


2235-2254
425
AAUAAAUUAUUGGCAUGAA
426
AAuAAAuuAuuGGcAuGAAdTsdT
sense


 


2235-2254
427
UUCAUGCCAAUAAUUUAUU
428
UUcAUGCcAAuAAUUuAUUdTsdT
antis


 


2243-2262
429
AUUGGCAUGAAACCCUUAA
430
AuuGGcAuGAAAcccuuAAdTsdT
sense


 


2243-2262
431
UUAAGGGUUUCAUGCCAAU
432
UuAAGGGUUUcAUGCcAAUdTsdT
antis


 


336-355
433
GGGAAAGCGUCAGUCGGGG
434
GGGAAAGcGucAGucGGGGdTsdT
sense


 


336-355
435
CCCCGACUGACGCUUUCCC
436
CCCCGACUGACGCUUUCCCdTsdT
antis


 


894-913
437
AUCCACUCCCAAGGUGUGU
438
AuccAcucccAAGGuGuGudTsdT
sense


 


894-913
439
ACACACCUUGGGAGUGGAU
440
AcAcACCUUGGGAGUGGAUdTsdT
antis


 


1070-1089
441
AGCCACAGAUUACACCUCG
442
AGccAcAGAuuAcAccucGdTsdT
sense


 


1070-1089
443
CGAGGUGUAAUCUGUGGCU
444
CGAGGUGuAAUCUGUGGCUdTsdT
antis


 


1346-1365
445
GGAGUACACGCCAUCCUCA
446
GGAGuAcAcGccAuccucAdTsdT
sense


 


1346-1365
447
UGAGGAUGGCGUGUACUCC
448
UGAGGAUGGCGUGuACUCCdTsdT
antis


 


1976-1995
449
GUCCCUUGUAAAUAGAACC
450
GucccuuGuAAAuAGAAccdTsdT
sense


 


1976-1995
451
GGUUCUAUUUACAAGGGAC
452
GGUUCuAUUuAcAAGGGACdTsdT
antis


 


1977-1996
453
UCCCUUGUAAAUAGAACCA
454
ucccuuGuAAAuAGAAccAdTsdT
sense


 


1977-1996
455
UGGUUCUAUUUACAAGGGA
456
UGGUUCuAUUuAcAAGGGAdTsdT
antis


 


2194-2213
457
AGUUUCCACAGUAAGGUUU
458
AGuuuccAcAGuAAGGuuudTsdT
sense


 


2194-2213
459
AAACCUUACUGUGGAAACU
460
AAACCUuACUGUGGAAACUdTsdT
antis


 


1229-1248
461
GAUGAACCCUAACUAUACG
462
GAuGAAcccuAAcuAuAcGdTsdT
sense


 


1229-1248
463
CGUAUAGUUAGGGUUCAUC
464
CGuAuAGUuAGGGUUcAUCdTsdT
antis


 


341-360
465
AGCGUCAGUCGGGGCUAUG
466
AGcGucAGucGGGGcuAuGdTsdT
sense


 


341-360
467
CAUAGCCCCGACUGACGCU
468
cAuAGCCCCGACUGACGCUdTsdT
antis


 


574-593
469
GCUCAUUCGGAGUAGUAUA
470
GcucAuucGGAGuAGuAuAdTsdT
sense


 


574-593
471
UAUACUACUCCGAAUGAGC
472
uAuACuACUCCGAAUGAGCdTsdT
antis


 


578-597
473
AUUCGGAGUAGUAUACCAG
474
AuucGGAGuAGuAuAccAGdTsdT
sense


 


578-597
475
CUGGUAUACUACUCCGAAU
476
CUGGuAuACuACUCCGAAUdTsdT
antis


 


672-691
477
CUGCAGAUUAUGCGUAAGC
478
cuGcAGAuuAuGcGuAAGcdTsdT
sense


 


672-691
479
GCUUACGCAUAAUCUGCAG
480
GCUuACGcAuAAUCUGcAGdTsdT
antis


 


673-692
481
UGCAGAUUAUGCGUAAGCU
482
uGcAGAuuAuGcGuAAGcudTsdT
sense


 


673-692
483
AGCUUACGCAUAAUCUGCA
484
AGCUuACGcAuAAUCUGcAdTsdT
antis


 


674-693
485
GCAGAUUAUGCGUAAGCUG
486
GcAGAuuAuGcGuAAGcuGdTsdT
sense


 


674-693
487
CAGCUUACGCAUAAUCUGC
488
cAGCUuACGcAuAAUCUGCdTsdT
antis


 


1433-1452
489
CCCCAACGACCGCCCGCUU
490
ccccAAcGAccGcccGcuudTsdT
sense


 


1433-1452
491
AAGCGGGCGGUCGUUGGGG
492
AAGCGGGCGGUCGUUGGGGdTsdT
antis


 


1434-1453
493
CCCAACGACCGCCCGCUUC
494
cccAAcGAccGcccGcuucdTsdT
sense


 


1434-1453
495
GAAGCGGGCGGUCGUUGGG
496
GAAGCGGGCGGUCGUUGGGdTsdT
antis


 


1640-1659
497
UGCUACCCUCGCUAGCUCU
498
uGcuAcccucGcuAGcucudTsdT
sense


 


1640-1659
499
AGAGCUAGCGAGGGUAGCA
500
AGAGCuAGCGAGGGuAGcAdTsdT
antis


 


458-477
501
GGGAGUGAAGCUGGGCCGU
502
GGGAGuGAAGcuGGGccGudTsdT
sense


 


458-477
503
ACGGCCCAGCUUCACUCCC
504
ACGGCCcAGCUUcACUCCCdTsdT
antis


 


459-478
505
GGAGUGAAGCUGGGCCGUG
506
GGAGuGAAGcuGGGccGuGdTsdT
sense


 


459-478
507
CACGGCCCAGCUUCACUCC
508
cACGGCCcAGCUUcACUCCdTsdT
antis


 


573-592
509
GGCUCAUUCGGAGUAGUAU
510
GGcucAuucGGAGuAGuAudTsdT
sense


 


573-592
511
AUACUACUCCGAAUGAGCC
512
AuACuACUCCGAAUGAGCCdTsdT
antis


 


575-594
513
CUCAUUCGGAGUAGUAUAC
514
cucAuucGGAGuAGuAuAcdTsdT
sense


 


575-594
515
GUAUACUACUCCGAAUGAG
516
GuAuACuACUCCGAAUGAGdTsdT
antis


 


576-595
517
UCAUUCGGAGUAGUAUACC
518
ucAuucGGAGuAGuAuAccdTsdT
sense


 


576-595
519
GGUAUACUACUCCGAAUGA
520
GGuAuACuACUCCGAAUGAdTsdT
antis


 


577-596
521
CAUUCGGAGUAGUAUACCA
522
cAuucGGAGuAGuAuAccAdTsdT
sense


 


577-596
523
UGGUAUACUACUCCGAAUG
524
UGGuAuACuACUCCGAAUGdTsdT
antis


 


579-598
525
UUCGGAGUAGUAUACCAGG
526
uucGGAGuAGuAuAccAGGdTsdT
sense


 


579-598
527
CCUGGUAUACUACUCCGAA
528
CCUGGuAuACuACUCCGAAdTsdT
antis


 


671-690
529
ACUGCAGAUUAUGCGUAAG
530
AcuGcAGAuuAuGcGuAAGdTsdT
sense


 


671-690
531
CUUACGCAUAAUCUGCAGU
532
CUuACGcAuAAUCUGcAGUdTsdT
antis


 


786-805
533
CCCGAGACGGUGUACCGAG
534
cccGAGAcGGuGuAccGAGdTsdT
sense


 


786-805
535
CUCGGUACACCGUCUCGGG
536
CUCGGuAcACCGUCUCGGGdTsdT
antis


 


787-806
537
CCGAGACGGUGUACCGAGU
538
ccGAGAcGGuGuAccGAGudTsdT
sense


 


787-806
539
ACUCGGUACACCGUCUCGG
540
ACUCGGuAcACCGUCUCGGdTsdT
antis


 


789-808
541
GAGACGGUGUACCGAGUGG
542
GAGAcGGuGuAccGAGuGGdTsdT
sense


 


789-808
543
CCACUCGGUACACCGUCUC
544
CcACUCGGuAcACCGUCUCdTsdT
antis


 


1065-1084
545
UUUGGAGCCACAGAUUACA
546
uuuGGAGccAcAGAuuAcAdTsdT
sense


 


1065-1084
547
UGUAAUCUGUGGCUCCAAA
548
UGuAAUCUGUGGCUCcAAAdTsdT
antis


 


1226-1245
549
AGAGAUGAACCCUAACUAU
550
AGAGAuGAAcccuAAcuAudTsdT
sense


 


1226-1245
551
AUAGUUAGGGUUCAUCUCU
552
AuAGUuAGGGUUcAUCUCUdTsdT
antis


 


1228-1247
553
AGAUGAACCCUAACUAUAC
554
AGAuGAAcccuAAcuAuAcdTsdT
sense


 


1228-1247
555
GUAUAGUUAGGGUUCAUCU
556
GuAuAGUuAGGGUUcAUCUdTsdT
antis


 


1636-1655
557
CAACUGCUACCCUCGCUAG
558
cAAcuGcuAcccucGcuAGdTsdT
sense


 


1636-1655
559
CUAGCGAGGGUAGCAGUUG
560
CuAGCGAGGGuAGcAGUUGdTsdT
antis


 


1639-1658
561
CUGCUACCCUCGCUAGCUC
562
cuGcuAcccucGcuAGcucdTsdT
sense


 


1639-1658
563
GAGCUAGCGAGGGUAGCAG
564
GAGCuAGCGAGGGuAGcAGdTsdT
antis


 


2036-2055
565
GUGUAAAUAGAUUGUUAUA
566
GuGuAAAuAGAuuGuuAuAdTsdT
sense


 


2036-2055
567
UAUAACAAUCUAUUUACAC
568
uAuAAcAAUCuAUUuAcACdTsdT
antis


 


426-445
569
GGCCCCGGCGCGGGCACUA
570
GGccccGGcGcGGGcAcuAdTsdT
sense


 


426-445
571
UAGUGCCCGCGCCGGGGCC
572
uAGUGCCCGCGCCGGGGCCdTsdT
antis


 


883-902
573
GCUUGGCCUACAUCCACUC
574
GcuuGGccuAcAuccAcucdTsdT
sense


 


883-902
575
GAGUGGAUGUAGGCCAAGC
576
GAGUGGAUGuAGGCcAAGCdTsdT
antis


 


1227-1246
577
GAGAUGAACCCUAACUAUA
578
GAGAuGAAcccuAAcuAuAdTsdT
sense


 


1227-1246
579
UAUAGUUAGGGUUCAUCUC
580
uAuAGUuAGGGUUcAUCUCdTsdT
antis


 


1369-1388
581
UCUCCCCACUCGAGGCUUG
582
ucuccccAcucGAGGcuuGdTsdT
sense


 


1369-1388
583
CAAGCCUCGAGUGGGGAGA
584
cAAGCCUCGAGUGGGGAGAdTsdT
antis


 


1393-1412
585
ACAGCUUCUUCGAUGAACU
586
AcAGcuucuucGAuGAAcudTsdT
sense


 


1393-1412
587
AGUUCAUCGAAGAAGCUGU
588
AGUUcAUCGAAGAAGCUGUdTsdT
antis


 


1431-1450
589
CUCCCCAACGACCGCCCGC
590
cuccccAAcGAccGcccGcdTsdT
sense


 


1431-1450
591
GCGGGCGGUCGUUGGGGAG
592
GCGGGCGGUCGUUGGGGAGdTsdT
antis


 


1436-1455
593
CAACGACCGCCCGCUUCCC
594
cAAcGAccGcccGcuucccdTsdT
sense


 


1436-1455
595
GGGAAGCGGGCGGUCGUUG
596
GGGAAGCGGGCGGUCGUUGdTsdT
antis


 


1437-1456
597
AACGACCGCCCGCUUCCCC
598
AAcGAccGcccGcuuccccdTsdT
sense


 


1437-1456
599
GGGGAAGCGGGCGGUCGUU
600
GGGGAAGCGGGCGGUCGUUdTsdT
antis


 


2176-2195
601
GAGAGUCCCUGGUGUCUUA
602
GAGAGucccuGGuGucuuAdTsdT
sense


 


2176-2195
603
UAAGACACCAGGGACUCUC
604
uAAGAcACcAGGGACUCUCdTsdT
antis


 


599-618
605
ACGGCUGGCAGAGACGAGG
606
AcGGcuGGcAGAGAcGAGGdTsdT
sense


 


599-618
607
CCUCGUCUCUGCCAGCCGU
608
CCUCGUCUCUGCcAGCCGUdTsdT
antis


 


706-725
609
UUGUGAGGCUGCGGUACUU
610
uuGuGAGGcuGcGGuAcuudTsdT
sense


 


706-725
611
AAGUACCGCAGCCUCACAA
612
AAGuACCGcAGCCUcAcAAdTsdT
antis


 


707-726
613
UGUGAGGCUGCGGUACUUU
614
uGuGAGGcuGcGGuAcuuudTsdT
sense


 


707-726
615
AAAGUACCGCAGCCUCACA
616
AAAGuACCGcAGCCUcAcAdTsdT
antis


 


791-810
617
GACGGUGUACCGAGUGGCC
618
GAcGGuGuAccGAGuGGccdTsdT
sense


 


791-810
619
GGCCACUCGGUACACCGUC
620
GGCcACUCGGuAcACCGUCdTsdT
antis


 


899-918
621
CUCCCAAGGUGUGUGUCAC
622
cucccAAGGuGuGuGucAcdTsdT
sense


 


899-918
623
GUGACACACACCUUGGGAG
624
GUGAcAcAcACCUUGGGAGdTsdT
antis


 


 989-1008
625
UGCAAAGCAGCUGGUUCGG
626
uGcAAAGcAGcuGGuucGGdTsdT
sense


 


 989-1008
627
CCGAACCAGCUGCUUUGCA
628
CCGAACcAGCUGCUUUGcAdTsdT
antis


 


1064-1083
629
CUUUGGAGCCACAGAUUAC
630
cuuuGGAGccAcAGAuuAcdTsdT
sense


 


1064-1083
631
GUAAUCUGUGGCUCCAAAG
632
GuAAUCUGUGGCUCcAAAGdTsdT
antis


 


1066-1085
633
UUGGAGCCACAGAUUACAC
634
uuGGAGccAcAGAuuAcAcdTsdT
sense


 


1066-1085
635
GUGUAAUCUGUGGCUCCAA
636
GUGuAAUCUGUGGCUCcAAdTsdT
antis


 


1125-1144
637
GAGCUACUUCUCGGCCAGC
638
GAGcuAcuucucGGccAGcdTsdT
sense


 


1125-1144
639
GCUGGCCGAGAAGUAGCUC
640
GCUGGCCGAGAAGuAGCUCdTsdT
antis


 


1225-1244
641
GAGAGAUGAACCCUAACUA
642
GAGAGAuGAAcccuAAcuAdTsdT
sense


 


1225-1244
643
UAGUUAGGGUUCAUCUCUC
644
uAGUuAGGGUUcAUCUCUCdTsdT
antis


 


1265-1284
645
GAUCAAAGCUCACCCUUGG
646
GAucAAAGcucAcccuuGGdTsdT
sense


 


1265-1284
647
CCAAGGGUGAGCUUUGAUC
648
CcAAGGGUGAGCUUUGAUCdTsdT
antis


 


1269-1288
649
AAAGCUCACCCUUGGACAA
650
AAAGcucAcccuuGGAcAAdTsdT
sense


 


1269-1288
651
UUGUCCAAGGGUGAGCUUU
652
UUGUCcAAGGGUGAGCUUUdTsdT
antis


 


1365-1384
653
AGGCUCUCCCCACUCGAGG
654
AGGcucuccccAcucGAGGdTsdT
sense


 


1365-1384
655
CCUCGAGUGGGGAGAGCCU
656
CCUCGAGUGGGGAGAGCCUdTsdT
antis


 


1481-1500
657
ACUGUCCAUCCAACCAUCU
658
AcuGuccAuccAAccAucudTsdT
sense


 


1481-1500
659
AGAUGGUUGGAUGGACAGU
660
AGAUGGUUGGAUGGAcAGUdTsdT
antis


 


1637-1656
661
AACUGCUACCCUCGCUAGC
662
AAcuGcuAcccucGcuAGcdTsdT
sense


 


1637-1656
663
GCUAGCGAGGGUAGCAGUU
664
GCuAGCGAGGGuAGcAGUUdTsdT
antis


 


1979-1998
665
CCUUGUAAAUAGAACCAGC
666
ccuuGuAAAuAGAAccAGcdTsdT
sense


 


1979-1998
667
GCUGGUUCUAUUUACAAGG
668
GCUGGUUCuAUUuAcAAGGdTsdT
antis


 


2196-2215
669
UUUCCACAGUAAGGUUUGC
670
uuuccAcAGuAAGGuuuGcdTsdT
sense


 


2196-2215
671
GCAAACCUUACUGUGGAAA
672
GcAAACCUuACUGUGGAAAdTsdT
antis


 


1978-1997
673
CCCUUGUAAAUAGAACCAG
674
cccuuGuAAAuAGAAccAGdTsdT
sense


 


1978-1997
675
CUGGUUCUAUUUACAAGGG
676
CUGGUUCuAUUuAcAAGGGdTsdT
antis


 


651-670
677
AAAAGGUUCAAGAACCGAG
678
AAAAGGuucAAGAAccGAGdTsdT
sense


 


651-670
679
CUCGGUUCUUGAACCUUUU
680
CUCGGUUCUUGAACCUUUUdTsdT
antis


 


702-721
681
AAUAUUGUGAGGCUGCGGU
682
AAuAuuGuGAGGcuGcGGudTsdT
sense


 


702-721
683
ACCGCAGCCUCACAAUAUU
684
ACCGcAGCCUcAcAAuAUUdTsdT
antis


 


1363-1382
685
CAAGGCUCUCCCCACUCGA
686
cAAGGcucuccccAcucGAdTsdT
sense


 


1363-1382
687
UCGAGUGGGGAGAGCCUUG
688
UCGAGUGGGGAGAGCCUUGdTsdT
antis


 


701-720
689
CAAUAUUGUGAGGCUGCGG
690
cAAuAuuGuGAGGcuGcGGdTsdT
sense


 


701-720
691
CCGCAGCCUCACAAUAUUG
692
CCGcAGCCUcAcAAuAUUGdTsdT
antis


 


1237-1256
693
CUAACUAUACGGAGUUCAA
694
cuAAcuAuAcGGAGuucAAdTsdT
sense


 


1237-1256
695
UUGAACUCCGUAUAGUUAG
696
UUGAACUCCGuAuAGUuAGdTsdT
antis


 


2064-2083
697
UAAAGAAAACGUCAAUUCA
698
uAAAGAAAAcGucAAuucAdTsdT
sense


 


2064-2083
699
UGAAUUGACGUUUUCUUUA
700
UGAAUUGACGUUUUCUUuAdTsdT
antis


 


828-847
701
AAGCUGAUCACCCCUAUCA
702
AAGcuGAucAccccuAucAdTsdT
sense


 


828-847
703
UGAUAGGGGUGAUCAGCUU
704
UGAuAGGGGUGAUcAGCUUdTsdT
antis


 


930-949
705
CCCCAGAAUUUGCUUGUGG
706
ccccAGAAuuuGcuuGuGGdTsdT
sense


 


930-949
707
CCACAAGCAAAUUCUGGGG
708
CcAcAAGcAAAUUCUGGGGdTsdT
antis


 


 995-1014
709
GCAGCUGGUUCGGGGGGAG
710
GcAGcuGGuucGGGGGGAGdTsdT
sense


 


 995-1014
711
CUCCCCCCGAACCAGCUGC
712
CUCCCCCCGAACcAGCUGCdTsdT
antis


 


1478-1497
713
UGAACUGUCCAUCCAACCA
714
uGAAcuGuccAuccAAccAdTsdT
sense


 


1478-1497
715
UGGUUGGAUGGACAGUUCA
716
UGGUUGGAUGGAcAGUUcAdTsdT
antis


 


1604-1623
717
GACUGGCCAAGAUUGGCAG
718
GAcuGGccAAGAuuGGcAGdTsdT
sense


 


1604-1623
719
CUGCCAAUCUUGGCCAGUC
720
CUGCcAAUCUUGGCcAGUCdTsdT
antis


 


1808-1827
721
CUCCCUCAGCAGCCUAACC
722
cucccucAGcAGccuAAccdTsdT
sense


 


1808-1827
723
GGUUAGGCUGCUGAGGGAG
724
GGUuAGGCUGCUGAGGGAGdTsdT
antis


 


2177-2196
725
AGAGUCCCUGGUGUCUUAG
726
AGAGucccuGGuGucuuAGdTsdT
sense


 


2177-2196
727
CUAAGACACCAGGGACUCU
728
CuAAGAcACcAGGGACUCUdTsdT
antis


 


 82-101
729
GAACGGCGCGGCCUGGAAG
730
GAAcGGcGcGGccuGGAAGdTsdT
sense


 


 82-101
731
CUUCCAGGCCGCGCCGUUC
732
CUUCcAGGCCGCGCCGUUCdTsdT
antis


 


1077-1096
733
GAUUACACCUCGUCCAUCG
734
GAuuAcAccucGuccAucGdTsdT
sense


 


1077-1096
735
CGAUGGACGAGGUGUAAUC
736
CGAUGGACGAGGUGuAAUCdTsdT
antis


 


1238-1257
737
UAACUAUACGGAGUUCAAG
738
uAAcuAuAcGGAGuucAAGdTsdT
sense


 


1238-1257
739
CUUGAACUCCGUAUAGUUA
740
CUUGAACUCCGuAuAGUuAdTsdT
antis


 


248-267
741
CAGCUCGUUCGCGGAGCCA
742
cAGcucGuucGcGGAGccAdTsdT
sense


 


248-267
743
UGGCUCCGCGAACGAGCUG
744
UGGCUCCGCGAACGAGCUGdTsdT
antis


 


250-269
745
GCUCGUUCGCGGAGCCAGG
746
GcucGuucGcGGAGccAGGdTsdT
sense


 


250-269
747
CCUGGCUCCGCGAACGAGC
748
CCUGGCUCCGCGAACGAGCdTsdT
antis


 


327-346
749
ACUGGCGGCGGGAAAGCGU
750
AcuGGcGGcGGGAAAGcGudTsdT
sense


 


327-346
751
ACGCUUUCCCGCCGCCAGU
752
ACGCUUUCCCGCCGCcAGUdTsdT
antis


 


332-351
753
CGGCGGGAAAGCGUCAGUC
754
cGGcGGGAAAGcGucAGucdTsdT
sense


 


332-351
755
GACUGACGCUUUCCCGCCG
756
GACUGACGCUUUCCCGCCGdTsdT
antis


 


376-395
757
CCUCGAGCUCCGGGGGUGG
758
ccucGAGcuccGGGGGuGGdTsdT
sense


 


376-395
759
CCACCCCCGGAGCUCGAGG
760
CcACCCCCGGAGCUCGAGGdTsdT
antis


 


468-487
761
CUGGGCCGUGACAGCGGGA
762
cuGGGccGuGAcAGcGGGAdTsdT
sense


 


468-487
763
UCCCGCUGUCACGGCCCAG
764
UCCCGCUGUcACGGCCcAGdTsdT
antis


 


584-603
765
AGUAGUAUACCAGGCACGG
766
AGuAGuAuAccAGGcAcGGdTsdT
sense


 


584-603
767
CCGUGCCUGGUAUACUACU
768
CCGUGCCUGGuAuACuACUdTsdT
antis


 


785-804
769
GCCCGAGACGGUGUACCGA
770
GcccGAGAcGGuGuAccGAdTsdT
sense


 


785-804
771
UCGGUACACCGUCUCGGGC
772
UCGGuAcACCGUCUCGGGCdTsdT
antis


 


1010-1029
773
GGAGCCCAAUGUGUCCUAC
774
GGAGcccAAuGuGuccuAcdTsdT
sense


 


1010-1029
775
GUAGGACACAUUGGGCUCC
776
GuAGGAcAcAUUGGGCUCCdTsdT
antis


 


1011-1030
777
GAGCCCAAUGUGUCCUACA
778
GAGcccAAuGuGuccuAcAdTsdT
sense


 


1011-1030
779
UGUAGGACACAUUGGGCUC
780
UGuAGGAcAcAUUGGGCUCdTsdT
antis


 


1021-1040
781
UGUCCUACAUCUGCUCUCG
782
uGuccuAcAucuGcucucGdTsdT
sense


 


1021-1040
783
CGAGAGCAGAUGUAGGACA
784
CGAGAGcAGAUGuAGGAcAdTsdT
antis


 


1022-1041
785
GUCCUACAUCUGCUCUCGG
786
GuccuAcAucuGcucucGGdTsdT
sense


 


1022-1041
787
CCGAGAGCAGAUGUAGGAC
788
CCGAGAGcAGAUGuAGGACdTsdT
antis


 


1023-1042
789
UCCUACAUCUGCUCUCGGU
790
uccuAcAucuGcucucGGudTsdT
sense


 


1023-1042
791
ACCGAGAGCAGAUGUAGGA
792
ACCGAGAGcAGAUGuAGGAdTsdT
antis


 


1072-1091
793
CCACAGAUUACACCUCGUC
794
ccAcAGAuuAcAccucGucdTsdT
sense


 


1072-1091
795
GACGAGGUGUAAUCUGUGG
796
GACGAGGUGuAAUCUGUGGdTsdT
antis


 


1127-1146
797
GCUACUUCUCGGCCAGCCC
798
GcuAcuucucGGccAGcccdTsdT
sense


 


1127-1146
799
GGGCUGGCCGAGAAGUAGC
800
GGGCUGGCCGAGAAGuAGCdTsdT
antis


 


1408-1427
801
AACUGCGGAGACUCGGAGC
802
AAcuGcGGAGAcucGGAGcdTsdT
sense


 


1408-1427
803
GCUCCGAGUCUCCGCAGUU
804
GCUCCGAGUCUCCGcAGUUdTsdT
antis


 


1432-1451
805
UCCCCAACGACCGCCCGCU
806
uccccAAcGAccGcccGcudTsdT
sense


 


1432-1451
807
AGCGGGCGGUCGUUGGGGA
808
AGCGGGCGGUCGUUGGGGAdTsdT
antis


 


1982-2001
809
UGUAAAUAGAACCAGCCCA
810
uGuAAAuAGAAccAGcccAdTsdT
sense


 


1982-2001
811
UGGGCUGGUUCUAUUUACA
812
UGGGCUGGUUCuAUUuAcAdTsdT
antis


 


2030-2049
813
CCCUGGGUGUAAAUAGAUU
814
cccuGGGuGuAAAuAGAuudTsdT
sense


 


2030-2049
815
AAUCUAUUUACACCCAGGG
816
AAUCuAUUuAcACCcAGGGdTsdT
antis


 


2073-2092
817
CGUCAAUUCACACCAUUCA
818
cGucAAuucAcAccAuucAdTsdT
sense


 


2073-2092
819
UGAAUGGUGUGAAUUGACG
820
UGAAUGGUGUGAAUUGACGdTsdT
antis


 


2218-2237
821
UGUACAGACCUCUGUUCAA
822
uGuAcAGAccucuGuucAAdTsdT
sense


 


2218-2237
823
UUGAACAGAGGUCUGUACA
824
UUGAAcAGAGGUCUGuAcAdTsdT
antis


 


2229-2248
825
CUGUUCAAUAAAUUAUUGG
826
cuGuucAAuAAAuuAuuGGdTsdT
sense


 


2229-2248
827
CCAAUAAUUUAUUGAACAG
828
CcAAuAAUUuAUUGAAcAGdTsdT
antis


 


 7-26
829
ACAACGAAGCCGACGGCAG
830
AcAAcGAAGccGAcGGcAGdTsdT
sense


 


 7-26
831
CUGCCGUCGGCUUCGUUGU
832
CUGCCGUCGGCUUCGUUGUdTsdT
antis


 


 8-27
833
CAACGAAGCCGACGGCAGA
834
cAAcGAAGccGAcGGcAGAdTsdT
sense


 


 8-27
835
UCUGCCGUCGGCUUCGUUG
836
UCUGCCGUCGGCUUCGUUGdTsdT
antis


 


76-95
837
GAGCCCGAACGGCGCGGCC
838
GAGcccGAAcGGcGcGGccdTsdT
sense


 


76-95
839
GGCCGCGCCGUUCGGGCUC
840
GGCCGCGCCGUUCGGGCUCdTsdT
antis


 


176-195
841
GCCUGCGCUCGGCGCCAUG
842
GccuGcGcucGGcGccAuGdTsdT
sense


 


176-195
843
CAUGGCGCCGAGCGCAGGC
844
cAUGGCGCCGAGCGcAGGCdTsdT
antis


 


434-453
845
CGCGGGCACUAGCUUCCCG
846
cGcGGGcAcuAGcuucccGdTsdT
sense


 


434-453
847
CGGGAAGCUAGUGCCCGCG
848
CGGGAAGCuAGUGCCCGCGdTsdT
antis


 


472-491
849
GCCGUGACAGCGGGAAGGU
850
GccGuGAcAGcGGGAAGGudTsdT
sense


 


472-491
851
ACCUUCCCGCUGUCACGGC
852
ACCUUCCCGCUGUcACGGCdTsdT
antis


 


537-556
853
GAAGUGGCUUACACUGACA
854
GAAGuGGcuuAcAcuGAcAdTsdT
sense


 


537-556
855
UGUCAGUGUAAGCCACUUC
856
UGUcAGUGuAAGCcACUUCdTsdT
antis


 


656-675
857
GUUCAAGAACCGAGAACUG
858
GuucAAGAAccGAGAAcuGdTsdT
sense


 


656-675
859
CAGUUCUCGGUUCUUGAAC
860
cAGUUCUCGGUUCUUGAACdTsdT
antis


 


657-676
861
UUCAAGAACCGAGAACUGC
862
uucAAGAAccGAGAAcuGcdTsdT
sense


 


657-676
863
GCAGUUCUCGGUUCUUGAA
864
GcAGUUCUCGGUUCUUGAAdTsdT
antis


 


784-803
865
UGCCCGAGACGGUGUACCG
866
uGcccGAGAcGGuGuAccGdTsdT
sense


 


784-803
867
CGGUACACCGUCUCGGGCA
868
CGGuAcACCGUCUCGGGcAdTsdT
antis


 


1404-1423
869
GAUGAACUGCGGAGACUCG
870
GAuGAAcuGcGGAGAcucGdTsdT
sense


 


1404-1423
871
CGAGUCUCCGCAGUUCAUC
872
CGAGUCUCCGcAGUUcAUCdTsdT
antis


 


1405-1424
873
AUGAACUGCGGAGACUCGG
874
AuGAAcuGcGGAGAcucGGdTsdT
sense


 


1405-1424
875
CCGAGUCUCCGCAGUUCAU
876
CCGAGUCUCCGcAGUUcAUdTsdT
antis


 


1445-1464
877
CCCGCUUCCCCCCCUGUUC
878
cccGcuucccccccuGuucdTsdT
sense


 


1445-1464
879
GAACAGGGGGGGAAGCGGG
880
GAAcAGGGGGGGAAGCGGGdTsdT
antis


 


1446-1465
881
CCGCUUCCCCCCCUGUUCA
882
ccGcuucccccccuGuucAdTsdT
sense


 


1446-1465
883
UGAACAGGGGGGGAAGCGG
884
UGAAcAGGGGGGGAAGCGGdTsdT
antis


 


1470-1489
885
AGUCCUGGUGAACUGUCCA
886
AGuccuGGuGAAcuGuccAdTsdT
sense


 


1470-1489
887
UGGACAGUUCACCAGGACU
888
UGGAcAGUUcACcAGGACUdTsdT
antis


 


1897-1916
889
GGGGGUGUGAGGACCUUCU
890
GGGGGuGuGAGGAccuucudTsdT
sense


 


1897-1916
891
AGAAGGUCCUCACACCCCC
892
AGAAGGUCCUcAcACCCCCdTsdT
antis


 


1937-1956
893
CCCCCAGGCUACCACUCCU
894
cccccAGGcuAccAcuccudTsdT
sense


 


1937-1956
895
AGGAGUGGUAGCCUGGGGG
896
AGGAGUGGuAGCCUGGGGGdTsdT
antis


 


1981-2000
897
UUGUAAAUAGAACCAGCCC
898
uuGuAAAuAGAAccAGcccdTsdT
sense


 


1981-2000
899
GGGCUGGUUCUAUUUACAA
900
GGGCUGGUUCuAUUuAcAAdTsdT
antis


 


1985-2004
901
AAAUAGAACCAGCCCAGCC
902
AAAuAGAAccAGcccAGccdTsdT
sense


 


1985-2004
903
GGCUGGGCUGGUUCUAUUU
904
GGCUGGGCUGGUUCuAUUUdTsdT
antis


 


2061-2080
905
UCUUAAAGAAAACGUCAAU
906
ucuuAAAGAAAAcGucAAudTsdT
sense


 


2061-2080
907
AUUGACGUUUUCUUUAAGA
908
AUUGACGUUUUCUUuAAGAdTsdT
antis


 


2065-2084
909
AAAGAAAACGUCAAUUCAC
910
AAAGAAAAcGucAAuucAcdTsdT
sense


 


2065-2084
911
GUGAAUUGACGUUUUCUUU
912
GUGAAUUGACGUUUUCUUUdTsdT
antis


 


 1-20
913
GUGGUGACAACGAAGCCGA
914
GuGGuGAcAAcGAAGccGAdTsdT
sense


 


 1-20
915
UCGGCUUCGUUGUCACCAC
916
UCGGCUUCGUUGUcACcACdTsdT
antis


 


11-30
917
CGAAGCCGACGGCAGAGGG
918
cGAAGccGAcGGcAGAGGGdTsdT
sense


 


11-30
919
CCCUCUGCCGUCGGCUUCG
920
CCCUCUGCCGUCGGCUUCGdTsdT
antis


 


70-89
921
GAGCCGGAGCCCGAACGGC
922
GAGccGGAGcccGAAcGGcdTsdT
sense


 


70-89
923
GCCGUUCGGGCUCCGGCUC
924
GCCGUUCGGGCUCCGGCUCdTsdT
antis


 


73-92
925
CCGGAGCCCGAACGGCGCG
926
ccGGAGcccGAAcGGcGcGdTsdT
sense


 


73-92
927
CGCGCCGUUCGGGCUCCGG
928
CGCGCCGUUCGGGCUCCGGdTsdT
antis


 


150-169
929
CAGGCAGCCCGAGCCCCGC
930
cAGGcAGcccGAGccccGcdTsdT
sense


 


150-169
931
GCGGGGCUCGGGCUGCCUG
932
GCGGGGCUCGGGCUGCCUGdTsdT
antis


 


178-197
933
CUGCGCUCGGCGCCAUGAG
934
cuGcGcucGGcGccAuGAGdTsdT
sense


 


178-197
935
CUCAUGGCGCCGAGCGCAG
936
CUcAUGGCGCCGAGCGcAGdTsdT
antis


 


180-199
937
GCGCUCGGCGCCAUGAGCG
938
GcGcucGGcGccAuGAGcGdTsdT
sense


 


180-199
939
CGCUCAUGGCGCCGAGCGC
940
CGCUcAUGGCGCCGAGCGCdTsdT
antis


 


196-215
941
GCGGCGGCGGGCCUUCGGG
942
GcGGcGGcGGGccuucGGGdTsdT
sense


 


196-215
943
CCCGAAGGCCCGCCGCCGC
944
CCCGAAGGCCCGCCGCCGCdTsdT
antis


 


202-221
945
GCGGGCCUUCGGGAGGCGG
946
GcGGGccuucGGGAGGcGGdTsdT
sense


 


202-221
947
CCGCCUCCCGAAGGCCCGC
948
CCGCCUCCCGAAGGCCCGCdTsdT
antis


 


223-242
949
CUGGGGGCUCGGGCCGGGC
950
cuGGGGGcucGGGccGGGcdTsdT
sense


 


223-242
951
GCCCGGCCCGAGCCCCCAG
952
GCCCGGCCCGAGCCCCcAGdTsdT
antis


 


238-257
953
GGGCGCGGACCAGCUCGUU
954
GGGcGcGGAccAGcucGuudTsdT
sense


 


238-257
955
AACGAGCUGGUCCGCGCCC
956
AACGAGCUGGUCCGCGCCCdTsdT
antis


 


317-336
957
CCCAGGAGGCACUGGCGGC
958
cccAGGAGGcAcuGGcGGcdTsdT
sense


 


317-336
959
GCCGCCAGUGCCUCCUGGG
960
GCCGCcAGUGCCUCCUGGGdTsdT
antis


 


337-356
961
GGAAAGCGUCAGUCGGGGC
962
GGAAAGcGucAGucGGGGcdTsdT
sense


 


337-356
963
GCCCCGACUGACGCUUUCC
964
GCCCCGACUGACGCUUUCCdTsdT
antis


 


436-455
965
CGGGCACUAGCUUCCCGCC
966
cGGGcAcuAGcuucccGccdTsdT
sense


 


436-455
967
GGCGGGAAGCUAGUGCCCG
968
GGCGGGAAGCuAGUGCCCGdTsdT
antis


 


449-468
969
CCCGCCGCCGGGAGUGAAG
970
cccGccGccGGGAGuGAAGdTsdT
sense


 


449-468
971
CUUCACUCCCGGCGGCGGG
972
CUUcACUCCCGGCGGCGGGdTsdT
antis


 


464-483
973
GAAGCUGGGCCGUGACAGC
974
GAAGcuGGGccGuGAcAGcdTsdT
sense


 


464-483
975
GCUGUCACGGCCCAGCUUC
976
GCUGUcACGGCCcAGCUUCdTsdT
antis


 


534-553
977
CAAGAAGUGGCUUACACUG
978
cAAGAAGuGGcuuAcAcuGdTsdT
sense


 


534-553
979
CAGUGUAAGCCACUUCUUG
980
cAGUGuAAGCcACUUCUUGdTsdT
antis


 


535-554
981
AAGAAGUGGCUUACACUGA
982
AAGAAGuGGcuuAcAcuGAdTsdT
sense


 


535-554
983
UCAGUGUAAGCCACUUCUU
984
UcAGUGuAAGCcACUUCUUdTsdT
antis


 


536-555
985
AGAAGUGGCUUACACUGAC
986
AGAAGuGGcuuAcAcuGAcdTsdT
sense


 


536-555
987
GUCAGUGUAAGCCACUUCU
988
GUcAGUGuAAGCcACUUCUdTsdT
antis


 


821-840
989
CAAGGCCAAGCUGAUCACC
990
cAAGGccAAGcuGAucAccdTsdT
sense


 


821-840
991
GGUGAUCAGCUUGGCCUUG
992
GGUGAUcAGCUUGGCCUUGdTsdT
antis


 


826-845
993
CCAAGCUGAUCACCCCUAU
994
ccAAGcuGAucAccccuAudTsdT
sense


 


826-845
995
AUAGGGGUGAUCAGCUUGG
996
AuAGGGGUGAUcAGCUUGGdTsdT
antis


 


897-916
997
CACUCCCAAGGUGUGUGUC
998
cAcucccAAGGuGuGuGucdTsdT
sense


 


897-916
999
GACACACACCUUGGGAGUG
1000
GAcAcAcACCUUGGGAGUGdTsdT
antis


 


898-917
1001
ACUCCCAAGGUGUGUGUCA
1002
AcucccAAGGuGuGuGucAdTsdT
sense


 


898-917
1003
UGACACACACCUUGGGAGU
1004
UGAcAcAcACCUUGGGAGUdTsdT
antis


 


 990-1009
1005
GCAAAGCAGCUGGUUCGGG
1006
GcAAAGcAGcuGGuucGGGdTsdT
sense


 


 990-1009
1007
CCCGAACCAGCUGCUUUGC
1008
CCCGAACcAGCUGCUUUGCdTsdT
antis


 


 992-1011
1009
AAAGCAGCUGGUUCGGGGG
1010
AAAGcAGcuGGuucGGGGGdTsdT
sense


 


 992-1011
1011
CCCCCGAACCAGCUGCUUU
1012
CCCCCGAACcAGCUGCUUUdTsdT
antis


 


 996-1015
1013
CAGCUGGUUCGGGGGGAGC
1014
cAGcuGGuucGGGGGGAGcdTsdT
sense


 


 996-1015
1015
GCUCCCCCCGAACCAGCUG
1016
GCUCCCCCCGAACcAGCUGdTsdT
antis


 


1007-1026
1017
GGGGGAGCCCAAUGUGUCC
1018
GGGGGAGcccAAuGuGuccdTsdT
sense


 


1007-1026
1019
GGACACAUUGGGCUCCCCC
1020
GGAcAcAUUGGGCUCCCCCdTsdT
antis


 


1013-1032
1021
GCCCAAUGUGUCCUACAUC
1022
GcccAAuGuGuccuAcAucdTsdT
sense


 


1013-1032
1023
GAUGUAGGACACAUUGGGC
1024
GAUGuAGGAcAcAUUGGGCdTsdT
antis


 


1030-1049
1025
UCUGCUCUCGGUACUACCG
1026
ucuGcucucGGuAcuAccGdTsdT
sense


 


1030-1049
1027
CGGUAGUACCGAGAGCAGA
1028
CGGuAGuACCGAGAGcAGAdTsdT
antis


 


1104-1123
1029
UCGGCUGGCUGUGUACUUG
1030
ucGGcuGGcuGuGuAcuuGdTsdT
sense


 


1104-1123
1031
CAAGUACACAGCCAGCCGA
1032
cAAGuAcAcAGCcAGCCGAdTsdT
antis


 


1109-1128
1033
UGGCUGUGUACUUGCUGAG
1034
uGGcuGuGuAcuuGcuGAGdTsdT
sense


 


1109-1128
1035
CUCAGCAAGUACACAGCCA
1036
CUcAGcAAGuAcAcAGCcAdTsdT
antis


 


1120-1139
1037
UUGCUGAGCUACUUCUCGG
1038
uuGcuGAGcuAcuucucGGdTsdT
sense


 


1120-1139
1039
CCGAGAAGUAGCUCAGCAA
1040
CCGAGAAGuAGCUcAGcAAdTsdT
antis


 


1122-1141
1041
GCUGAGCUACUUCUCGGCC
1042
GcuGAGcuAcuucucGGccdTsdT
sense


 


1122-1141
1043
GGCCGAGAAGUAGCUCAGC
1044
GGCCGAGAAGuAGCUcAGCdTsdT
antis


 


1266-1285
1045
AUCAAAGCUCACCCUUGGA
1046
AucAAAGcucAcccuuGGAdTsdT
sense


 


1266-1285
1047
UCCAAGGGUGAGCUUUGAU
1048
UCcAAGGGUGAGCUUUGAUdTsdT
antis


 


1329-1348
1049
CUCUGCUCUAGCCUACUGG
1050
cucuGcucuAGccuAcuGGdTsdT
sense


 


1329-1348
1051
CCAGUAGGCUAGAGCAGAG
1052
CcAGuAGGCuAGAGcAGAGdTsdT
antis


 


1343-1362
1053
ACUGGAGUACACGCCAUCC
1054
AcuGGAGuAcAcGccAuccdTsdT
sense


 


1343-1362
1055
GGAUGGCGUGUACUCCAGU
1056
GGAUGGCGUGuACUCcAGUdTsdT
antis


 


1364-1383
1057
AAGGCUCUCCCCACUCGAG
1058
AAGGcucuccccAcucGAGdTsdT
sense


 


1364-1383
1059
CUCGAGUGGGGAGAGCCUU
1060
CUCGAGUGGGGAGAGCCUUdTsdT
antis


 


1411-1430
1061
UGCGGAGACUCGGAGCCCA
1062
uGcGGAGAcucGGAGcccAdTsdT
sense


 


1411-1430
1063
UGGGCUCCGAGUCUCCGCA
1064
UGGGCUCCGAGUCUCCGcAdTsdT
antis


 


1570-1589
1065
ACAACCCAUCCUCACAAGC
1066
AcAAcccAuccucAcAAGcdTsdT
sense


 


1570-1589
1067
GCUUGUGAGGAUGGGUUGU
1068
GCUUGUGAGGAUGGGUUGUdTsdT
antis


 


1589-1608
1069
UUUAACUGAAGCUCAGACU
1070
uuuAAcuGAAGcucAGAcudTsdT
sense


 


1589-1608
1071
AGUCUGAGCUUCAGUUAAA
1072
AGUCUGAGCUUcAGUuAAAdTsdT
antis


 


1609-1628
1073
GCCAAGAUUGGCAGCCAUC
1074
GccAAGAuuGGcAGccAucdTsdT
sense


 


1609-1628
1075
GAUGGCUGCCAAUCUUGGC
1076
GAUGGCUGCcAAUCUUGGCdTsdT
antis


 


1613-1632
1077
AGAUUGGCAGCCAUCUGAU
1078
AGAuuGGcAGccAucuGAudTsdT
sense


 


1613-1632
1079
AUCAGAUGGCUGCCAAUCU
1080
AUcAGAUGGCUGCcAAUCUdTsdT
antis


 


1615-1634
1081
AUUGGCAGCCAUCUGAUGC
1082
AuuGGcAGccAucuGAuGcdTsdT
sense


 


1615-1634
1083
GCAUCAGAUGGCUGCCAAU
1084
GcAUcAGAUGGCUGCcAAUdTsdT
antis


 


1809-1828
1085
UCCCUCAGCAGCCUAACCU
1086
ucccucAGcAGccuAAccudTsdT
sense


 


1809-1828
1087
AGGUUAGGCUGCUGAGGGA
1088
AGGUuAGGCUGCUGAGGGAdTsdT
antis


 


1844-1863
1089
AAAGAGGAUUUUAACUGUU
1090
AAAGAGGAuuuuAAcuGuudTsdT
sense


 


1844-1863
1091
AACAGUUAAAAUCCUCUUU
1092
AAcAGUuAAAAUCCUCUUUdTsdT
antis


 


1847-1866
1093
GAGGAUUUUAACUGUUUGU
1094
GAGGAuuuuAAcuGuuuGudTsdT
sense


 


1847-1866
1095
ACAAACAGUUAAAAUCCUC
1096
AcAAAcAGUuAAAAUCCUCdTsdT
antis


 


1853-1872
1097
UUUAACUGUUUGUAGGGGA
1098
uuuAAcuGuuuGuAGGGGAdTsdT
sense


 


1853-1872
1099
UCCCCUACAAACAGUUAAA
1100
UCCCCuAcAAAcAGUuAAAdTsdT
antis


 


1857-1876
1101
ACUGUUUGUAGGGGAGGGG
1102
AcuGuuuGuAGGGGAGGGGdTsdT
sense


 


1857-1876
1103
CCCCUCCCCUACAAACAGU
1104
CCCCUCCCCuAcAAAcAGUdTsdT
antis


 


1896-1915
1105
UGGGGGUGUGAGGACCUUC
1106
uGGGGGuGuGAGGAccuucdTsdT
sense


 


1896-1915
1107
GAAGGUCCUCACACCCCCA
1108
GAAGGUCCUcAcACCCCcAdTsdT
antis


 


1936-1955
1109
UCCCCCAGGCUACCACUCC
1110
ucccccAGGcuAccAcuccdTsdT
sense


 


1936-1955
1111
GGAGUGGUAGCCUGGGGGA
1112
GGAGUGGuAGCCUGGGGGAdTsdT
antis


 


1967-1986
1113
CUCUCCCAGGUCCCUUGUA
1114
cucucccAGGucccuuGuAdTsdT
sense


 


1967-1986
1115
UACAAGGGACCUGGGAGAG
1116
uAcAAGGGACCUGGGAGAGdTsdT
antis


 


1997-2016
1117
CCCAGCCCAUCUCUCGUCU
1118
cccAGcccAucucucGucudTsdT
sense


 


1997-2016
1119
AGACGAGAGAUGGGCUGGG
1120
AGACGAGAGAUGGGCUGGGdTsdT
antis


 


2001-2020
1121
GCCCAUCUCUCGUCUUCCC
1122
GcccAucucucGucuucccdTsdT
sense


 


2001-2020
1123
GGGAAGACGAGAGAUGGGC
1124
GGGAAGACGAGAGAUGGGCdTsdT
antis


 


2074-2093
1125
GUCAAUUCACACCAUUCAA
1126
GucAAuucAcAccAuucAAdTsdT
sense


 


2074-2093
1127
UUGAAUGGUGUGAAUUGAC
1128
UUGAAUGGUGUGAAUUGACdTsdT
antis


 


2093-2112
1129
CUUGCCCCCCCCAGCUGUA
1130
cuuGccccccccAGcuGuAdTsdT
sense


 


2093-2112
1131
UACAGCUGGGGGGGGCAAG
1132
uAcAGCUGGGGGGGGcAAGdTsdT
antis


 


2164-2183
1133
GAGGGGAGUAGAGAGAGUC
1134
GAGGGGAGuAGAGAGAGucdTsdT
sense


 


2164-2183
1135
GACUCUCUCUACUCCCCUC
1136
GACUCUCUCuACUCCCCUCdTsdT
antis


 


2168-2187
1137
GGAGUAGAGAGAGUCCCUG
1138
GGAGuAGAGAGAGucccuGdTsdT
sense


 


2168-2187
1139
CAGGGACUCUCUCUACUCC
1140
cAGGGACUCUCUCuACUCCdTsdT
antis


 


2185-2204
1141
UGGUGUCUUAGUUUCCACA
1142
uGGuGucuuAGuuuccAcAdTsdT
sense


 


2185-2204
1143
UGUGGAAACUAAGACACCA
1144
UGUGGAAACuAAGAcACcAdTsdT
antis


 


2191-2210
1145
CUUAGUUUCCACAGUAAGG
1146
cuuAGuuuccAcAGuAAGGdTsdT
sense


 


2191-2210
1147
CCUUACUGUGGAAACUAAG
1148
CCUuACUGUGGAAACuAAGdTsdT
antis


 


2202-2221
1149
CAGUAAGGUUUGCCUGUGU
1150
cAGuAAGGuuuGccuGuGudTsdT
sense


 


2202-2221
1151
ACACAGGCAAACCUUACUG
1152
AcAcAGGcAAACCUuACUGdTsdT
antis


 


2242-2261
1153
UAUUGGCAUGAAACCCUUA
1154
uAuuGGcAuGAAAcccuuAdTsdT
sense


 


2242-2261
1155
UAAGGGUUUCAUGCCAAUA
1156
uAAGGGUUUcAUGCcAAuAdTsdT
antis


 


388-407
1157
GGGGUGGCCCCAGCGGCAG
1158
GGGGuGGccccAGcGGcAGdTsdT
sense


 


388-407
1159
CUGCCGCUGGGGCCACCCC
1160
CUGCCGCUGGGGCcACCCCdTsdT
antis


 


425-444
1161
UGGCCCCGGCGCGGGCACU
1162
uGGccccGGcGcGGGcAcudTsdT
sense


 


425-444
1163
AGUGCCCGCGCCGGGGCCA
1164
AGUGCCCGCGCCGGGGCcAdTsdT
antis


 


2163-2182
1165
GGAGGGGAGUAGAGAGAGU
1166
GGAGGGGAGuAGAGAGAGudTsdT
sense


 


2163-2182
1167
ACUCUCUCUACUCCCCUCC
1168
ACUCUCUCuACUCCCCUCCdTsdT
antis


 


 3-22
1169
GGUGACAACGAAGCCGACG
1170
GGuGAcAAcGAAGccGAcGdTsdT
sense


 


 3-22
1171
CGUCGGCUUCGUUGUCACC
1172
CGUCGGCUUCGUUGUcACCdTsdT
antis


 


12-31
1173
GAAGCCGACGGCAGAGGGA
1174
GAAGccGAcGGcAGAGGGAdTsdT
sense


 


12-31
1175
UCCCUCUGCCGUCGGCUUC
1176
UCCCUCUGCCGUCGGCUUCdTsdT
antis


 


72-91
1177
GCCGGAGCCCGAACGGCGC
1178
GccGGAGcccGAAcGGcGcdTsdT
sense


 


72-91
1179
GCGCCGUUCGGGCUCCGGC
1180
GCGCCGUUCGGGCUCCGGCdTsdT
antis


 


 90-109
1181
CGGCCUGGAAGAGGCCGGA
1182
cGGccuGGAAGAGGccGGAdTsdT
sense


 


 90-109
1183
UCCGGCCUCUUCCAGGCCG
1184
UCCGGCCUCUUCcAGGCCGdTsdT
antis


 


316-335
1185
GCCCAGGAGGCACUGGCGG
1186
GcccAGGAGGcAcuGGcGGdTsdT
sense


 


316-335
1187
CCGCCAGUGCCUCCUGGGC
1188
CCGCcAGUGCCUCCUGGGCdTsdT
antis


 


335-354
1189
CGGGAAAGCGUCAGUCGGG
1190
cGGGAAAGcGucAGucGGGdTsdT
sense


 


335-354
1191
CCCGACUGACGCUUUCCCG
1192
CCCGACUGACGCUUUCCCGdTsdT
antis


 


466-485
1193
AGCUGGGCCGUGACAGCGG
1194
AGcuGGGccGuGAcAGcGGdTsdT
sense


 


466-485
1195
CCGCUGUCACGGCCCAGCU
1196
CCGCUGUcACGGCCcAGCUdTsdT
antis


 


489-508
1197
GUGACCACAGUGGUAGCCA
1198
GuGAccAcAGuGGuAGccAdTsdT
sense


 


489-508
1199
UGGCUACCACUGUGGUCAC
1200
UGGCuACcACUGUGGUcACdTsdT
antis


 


708-727
1201
GUGAGGCUGCGGUACUUUU
1202
GuGAGGcuGcGGuAcuuuudTsdT
sense


 


708-727
1203
AAAAGUACCGCAGCCUCAC
1204
AAAAGuACCGcAGCCUcACdTsdT
antis


 


1098-1117
1205
GUGUGGUCGGCUGGCUGUG
1206
GuGuGGucGGcuGGcuGuGdTsdT
sense


 


1098-1117
1207
CACAGCCAGCCGACCACAC
1208
cAcAGCcAGCCGACcAcACdTsdT
antis


 


1117-1136
1209
UACUUGCUGAGCUACUUCU
1210
uAcuuGcuGAGcuAcuucudTsdT
sense


 


1117-1136
1211
AGAAGUAGCUCAGCAAGUA
1212
AGAAGuAGCUcAGcAAGuAdTsdT
antis


 


1305-1324
1213
AAGACACCACCUGAGGCCA
1214
AAGAcAccAccuGAGGccAdTsdT
sense


 


1305-1324
1215
UGGCCUCAGGUGGUGUCUU
1216
UGGCCUcAGGUGGUGUCUUdTsdT
antis


 


1341-1360
1217
CUACUGGAGUACACGCCAU
1218
cuAcuGGAGuAcAcGccAudTsdT
sense


 


1341-1360
1219
AUGGCGUGUACUCCAGUAG
1220
AUGGCGUGuACUCcAGuAGdTsdT
antis


 


1345-1364
1221
UGGAGUACACGCCAUCCUC
1222
uGGAGuAcAcGccAuccucdTsdT
sense


 


1345-1364
1223
GAGGAUGGCGUGUACUCCA
1224
GAGGAUGGCGUGuACUCcAdTsdT
antis


 


1811-1830
1225
CCUCAGCAGCCUAACCUCU
1226
ccucAGcAGccuAAccucudTsdT
sense


 


1811-1830
1227
AGAGGUUAGGCUGCUGAGG
1228
AGAGGUuAGGCUGCUGAGGdTsdT
antis


 


1850-1869
1229
GAUUUUAACUGUUUGUAGG
1230
GAuuuuAAcuGuuuGuAGGdTsdT
sense


 


1850-1869
1231
CCUACAAACAGUUAAAAUC
1232
CCuAcAAAcAGUuAAAAUCdTsdT
antis


 


1969-1988
1233
CUCCCAGGUCCCUUGUAAA
1234
cucccAGGucccuuGuAAAdTsdT
sense


 


1969-1988
1235
UUUACAAGGGACCUGGGAG
1236
UUuAcAAGGGACCUGGGAGdTsdT
antis


 


2162-2181
1237
AGGAGGGGAGUAGAGAGAG
1238
AGGAGGGGAGuAGAGAGAGdTsdT
sense


 


2162-2181
1239
CUCUCUCUACUCCCCUCCU
1240
CUCUCUCuACUCCCCUCCUdTsdT
antis


 


2195-2214
1241
GUUUCCACAGUAAGGUUUG
1242
GuuuccAcAGuAAGGuuuGdTsdT
sense


 


2195-2214
1243
CAAACCUUACUGUGGAAAC
1244
cAAACCUuACUGUGGAAACdTsdT
antis


 


1239-1258
1245
AACUAUACGGAGUUCAAGU
1246
AAcuAuAcGGAGuucAAGudTsdT
sense


 


1239-1258
1247
ACUUGAACUCCGUAUAGUU
1248
ACUUGAACUCCGuAuAGUUdTsdT
antis


 


1240-1259
1249
ACUAUACGGAGUUCAAGUU
1250
AcuAuAcGGAGuucAAGuudTsdT
sense


 


1240-1259
1251
AACUUGAACUCCGUAUAGU
1252
AACUUGAACUCCGuAuAGUdTsdT
antis


 


80-99
1253
CCGAACGGCGCGGCCUGGA
1254
ccGAAcGGcGcGGccuGGAdTsdT
sense


 


80-99
1255
UCCAGGCCGCGCCGUUCGG
1256
UCcAGGCCGCGCCGUUCGGdTsdT
antis


 


745-764
1257
AGAAGGACGAGCUGUAUUU
1258
AGAAGGAcGAGcuGuAuuudTsdT
sense


 


745-764
1259
AAAUACAGCUCGUCCUUCU
1260
AAAuAcAGCUCGUCCUUCUdTsdT
antis


 


1078-1097
1261
AUUACACCUCGUCCAUCGA
1262
AuuAcAccucGuccAucGAdTsdT
sense


 


1078-1097
1263
UCGAUGGACGAGGUGUAAU
1264
UCGAUGGACGAGGUGuAAUdTsdT
antis


 


2071-2090
1265
AACGUCAAUUCACACCAUU
1266
AAcGucAAuucAcAccAuudTsdT
sense


 


2071-2090
1267
AAUGGUGUGAAUUGACGUU
1268
AAUGGUGUGAAUUGACGUUdTsdT
antis


 


15-34
1269
GCCGACGGCAGAGGGACUU
1270
GccGAcGGcAGAGGGAcuudTsdT
sense


 


15-34
1271
AAGUCCCUCUGCCGUCGGC
1272
AAGUCCCUCUGCCGUCGGCdTsdT
antis


 


77-96
1273
AGCCCGAACGGCGCGGCCU
1274
AGcccGAAcGGcGcGGccudTsdT
sense


 


77-96
1275
AGGCCGCGCCGUUCGGGCU
1276
AGGCCGCGCCGUUCGGGCUdTsdT
antis


 


182-201
1277
GCUCGGCGCCAUGAGCGGC
1278
GcucGGcGccAuGAGcGGcdTsdT
sense


 


182-201
1279
GCCGCUCAUGGCGCCGAGC
1280
GCCGCUcAUGGCGCCGAGCdTsdT
antis


 


659-678
1281
CAAGAACCGAGAACUGCAG
1282
cAAGAAccGAGAAcuGcAGdTsdT
sense


 


659-678
1283
CUGCAGUUCUCGGUUCUUG
1284
CUGcAGUUCUCGGUUCUUGdTsdT
antis


 


788-807
1285
CGAGACGGUGUACCGAGUG
1286
cGAGAcGGuGuAccGAGuGdTsdT
sense


 


788-807
1287
CACUCGGUACACCGUCUCG
1288
cACUCGGuAcACCGUCUCGdTsdT
antis


 


1002-1021
1289
GUUCGGGGGGAGCCCAAUG
1290
GuucGGGGGGAGcccAAuGdTsdT
sense


 


1002-1021
1291
CAUUGGGCUCCCCCCGAAC
1292
cAUUGGGCUCCCCCCGAACdTsdT
antis


 


1333-1352
1293
GCUCUAGCCUACUGGAGUA
1294
GcucuAGccuAcuGGAGuAdTsdT
sense


 


1333-1352
1295
UACUCCAGUAGGCUAGAGC
1296
uACUCcAGuAGGCuAGAGCdTsdT
antis


 


1435-1454
1297
CCAACGACCGCCCGCUUCC
1298
ccAAcGAccGcccGcuuccdTsdT
sense


 


1435-1454
1299
GGAAGCGGGCGGUCGUUGG
1300
GGAAGCGGGCGGUCGUUGGdTsdT
antis


 


2246-2265
1301
GGCAUGAAACCCUUAAAAA
1302
GGcAuGAAAcccuuAAAAAdTsdT
sense


 


2246-2265
1303
UUUUUAAGGGUUUCAUGCC
1304
UUUUuAAGGGUUUcAUGCCdTsdT
antis


 


14-33
1305
AGCCGACGGCAGAGGGACU
1306
AGccGAcGGcAGAGGGAcudTsdT
sense


 


14-33
1307
AGUCCCUCUGCCGUCGGCU
1308
AGUCCCUCUGCCGUCGGCUdTsdT
antis


 


17-36
1309
CGACGGCAGAGGGACUUCA
1310
cGAcGGcAGAGGGAcuucAdTsdT
sense


 


17-36
1311
UGAAGUCCCUCUGCCGUCG
1312
UGAAGUCCCUCUGCCGUCGdTsdT
antis


 


18-37
1313
GACGGCAGAGGGACUUCAU
1314
GAcGGcAGAGGGAcuucAudTsdT
sense


 


18-37
1315
AUGAAGUCCCUCUGCCGUC
1316
AUGAAGUCCCUCUGCCGUCdTsdT
antis


 


78-97
1317
GCCCGAACGGCGCGGCCUG
1318
GcccGAAcGGcGcGGccuGdTsdT
sense


 


78-97
1319
CAGGCCGCGCCGUUCGGGC
1320
cAGGCCGCGCCGUUCGGGCdTsdT
antis


 


 81-100
1321
CGAACGGCGCGGCCUGGAA
1322
cGAAcGGcGcGGccuGGAAdTsdT
sense


 


 81-100
1323
UUCCAGGCCGCGCCGUUCG
1324
UUCcAGGCCGCGCCGUUCGdTsdT
antis


 


 83-102
1325
AACGGCGCGGCCUGGAAGA
1326
AAcGGcGcGGccuGGAAGAdTsdT
sense


 


 83-102
1327
UCUUCCAGGCCGCGCCGUU
1328
UCUUCcAGGCCGCGCCGUUdTsdT
antis


 


 87-106
1329
GCGCGGCCUGGAAGAGGCC
1330
GcGcGGccuGGAAGAGGccdTsdT
sense


 


 87-106
1331
GGCCUCUUCCAGGCCGCGC
1332
GGCCUCUUCcAGGCCGCGCdTsdT
antis


 


181-200
1333
CGCUCGGCGCCAUGAGCGG
1334
cGcucGGcGccAuGAGcGGdTsdT
sense


 


181-200
1335
CCGCUCAUGGCGCCGAGCG
1336
CCGCUcAUGGCGCCGAGCGdTsdT
antis


 


183-202
1337
CUCGGCGCCAUGAGCGGCG
1338
cucGGcGccAuGAGcGGcGdTsdT
sense


 


183-202
1339
CGCCGCUCAUGGCGCCGAG
1340
CGCCGCUcAUGGCGCCGAGdTsdT
antis


 


189-208
1341
GCCAUGAGCGGCGGCGGGC
1342
GccAuGAGcGGcGGcGGGcdTsdT
sense


 


189-208
1343
GCCCGCCGCCGCUCAUGGC
1344
GCCCGCCGCCGCUcAUGGCdTsdT
antis


 


191-210
1345
CAUGAGCGGCGGCGGGCCU
1346
cAuGAGcGGcGGcGGGccudTsdT
sense


 


191-210
1347
AGGCCCGCCGCCGCUCAUG
1348
AGGCCCGCCGCCGCUcAUGdTsdT
antis


 


254-273
1349
GUUCGCGGAGCCAGGAGGC
1350
GuucGcGGAGccAGGAGGcdTsdT
sense


 


254-273
1351
GCCUCCUGGCUCCGCGAAC
1352
GCCUCCUGGCUCCGCGAACdTsdT
antis


 


255-274
1353
UUCGCGGAGCCAGGAGGCG
1354
uucGcGGAGccAGGAGGcGdTsdT
sense


 


255-274
1355
CGCCUCCUGGCUCCGCGAA
1356
CGCCUCCUGGCUCCGCGAAdTsdT
antis


 


431-450
1357
CGGCGCGGGCACUAGCUUC
1358
cGGcGcGGGcAcuAGcuucdTsdT
sense


 


431-450
1359
GAAGCUAGUGCCCGCGCCG
1360
GAAGCuAGUGCCCGCGCCGdTsdT
antis


 


433-452
1361
GCGCGGGCACUAGCUUCCC
1362
GcGcGGGcAcuAGcuucccdTsdT
sense


 


433-452
1363
GGGAAGCUAGUGCCCGCGC
1364
GGGAAGCuAGUGCCCGCGCdTsdT
antis


 


441-460
1365
ACUAGCUUCCCGCCGCCGG
1366
AcuAGcuucccGccGccGGdTsdT
sense


 


441-460
1367
CCGGCGGCGGGAAGCUAGU
1368
CCGGCGGCGGGAAGCuAGUdTsdT
antis


 


442-461
1369
CUAGCUUCCCGCCGCCGGG
1370
cuAGcuucccGccGccGGGdTsdT
sense


 


442-461
1371
CCCGGCGGCGGGAAGCUAG
1372
CCCGGCGGCGGGAAGCuAGdTsdT
antis


 


446-465
1373
CUUCCCGCCGCCGGGAGUG
1374
cuucccGccGccGGGAGuGdTsdT
sense


 


446-465
1375
CACUCCCGGCGGCGGGAAG
1376
cACUCCCGGCGGCGGGAAGdTsdT
antis


 


473-492
1377
CCGUGACAGCGGGAAGGUG
1378
ccGuGAcAGcGGGAAGGuGdTsdT
sense


 


473-492
1379
CACCUUCCCGCUGUCACGG
1380
cACCUUCCCGCUGUcACGGdTsdT
antis


 


532-551
1381
CCCAAGAAGUGGCUUACAC
1382
cccAAGAAGuGGcuuAcAcdTsdT
sense


 


532-551
1383
GUGUAAGCCACUUCUUGGG
1384
GUGuAAGCcACUUCUUGGGdTsdT
antis


 


580-599
1385
UCGGAGUAGUAUACCAGGC
1386
ucGGAGuAGuAuAccAGGcdTsdT
sense


 


580-599
1387
GCCUGGUAUACUACUCCGA
1388
GCCUGGuAuACuACUCCGAdTsdT
antis


 


589-608
1389
UAUACCAGGCACGGCUGGC
1390
uAuAccAGGcAcGGcuGGcdTsdT
sense


 


589-608
1391
GCCAGCCGUGCCUGGUAUA
1392
GCcAGCCGUGCCUGGuAuAdTsdT
antis


 


598-617
1393
CACGGCUGGCAGAGACGAG
1394
cAcGGcuGGcAGAGAcGAGdTsdT
sense


 


598-617
1395
CUCGUCUCUGCCAGCCGUG
1396
CUCGUCUCUGCcAGCCGUGdTsdT
antis


 


837-856
1397
ACCCCUAUCAUCUACAUCA
1398
AccccuAucAucuAcAucAdTsdT
sense


 


837-856
1399
UGAUGUAGAUGAUAGGGGU
1400
UGAUGuAGAUGAuAGGGGUdTsdT
antis


 


838-857
1401
CCCCUAUCAUCUACAUCAA
1402
ccccuAucAucuAcAucAAdTsdT
sense


 


838-857
1403
UUGAUGUAGAUGAUAGGGG
1404
UUGAUGuAGAUGAuAGGGGdTsdT
antis


 


839-858
1405
CCCUAUCAUCUACAUCAAG
1406
cccuAucAucuAcAucAAGdTsdT
sense


 


839-858
1407
CUUGAUGUAGAUGAUAGGG
1408
CUUGAUGuAGAUGAuAGGGdTsdT
antis


 


922-941
1409
ACAUCAAGCCCCAGAAUUU
1410
AcAucAAGccccAGAAuuudTsdT
sense


 


922-941
1411
AAAUUCUGGGGCUUGAUGU
1412
AAAUUCUGGGGCUUGAUGUdTsdT
antis


 


923-942
1413
CAUCAAGCCCCAGAAUUUG
1414
cAucAAGccccAGAAuuuGdTsdT
sense


 


923-942
1415
CAAAUUCUGGGGCUUGAUG
1416
cAAAUUCUGGGGCUUGAUGdTsdT
antis


 


1012-1031
1417
AGCCCAAUGUGUCCUACAU
1418
AGcccAAuGuGuccuAcAudTsdT
sense


 


1012-1031
1419
AUGUAGGACACAUUGGGCU
1420
AUGuAGGAcAcAUUGGGCUdTsdT
antis


 


1014-1033
1421
CCCAAUGUGUCCUACAUCU
1422
cccAAuGuGuccuAcAucudTsdT
sense


 


1014-1033
1423
AGAUGUAGGACACAUUGGG
1424
AGAUGuAGGAcAcAUUGGGdTsdT
antis


 


1046-1065
1425
CCGUGCUCCAGAACUCAUC
1426
ccGuGcuccAGAAcucAucdTsdT
sense


 


1046-1065
1427
GAUGAGUUCUGGAGCACGG
1428
GAUGAGUUCUGGAGcACGGdTsdT
antis


 


1056-1075
1429
GAACUCAUCUUUGGAGCCA
1430
GAAcucAucuuuGGAGccAdTsdT
sense


 


1056-1075
1431
UGGCUCCAAAGAUGAGUUC
1432
UGGCUCcAAAGAUGAGUUCdTsdT
antis


 


1088-1107
1433
GUCCAUCGAUGUGUGGUCG
1434
GuccAucGAuGuGuGGucGdTsdT
sense


 


1088-1107
1435
CGACCACACAUCGAUGGAC
1436
CGACcAcAcAUCGAUGGACdTsdT
antis


 


1123-1142
1437
CUGAGCUACUUCUCGGCCA
1438
cuGAGcuAcuucucGGccAdTsdT
sense


 


1123-1142
1439
UGGCCGAGAAGUAGCUCAG
1440
UGGCCGAGAAGuAGCUcAGdTsdT
antis


 


1232-1251
1441
GAACCCUAACUAUACGGAG
1442
GAAcccuAAcuAuAcGGAGdTsdT
sense


 


1232-1251
1443
CUCCGUAUAGUUAGGGUUC
1444
CUCCGuAuAGUuAGGGUUCdTsdT
antis


 


1287-1306
1445
AAGGUGUUCAAAUCUUCAA
1446
AAGGuGuucAAAucuucAAdTsdT
sense


 


1287-1306
1447
UUGAAGAUUUGAACACCUU
1448
UUGAAGAUUUGAAcACCUUdTsdT
antis


 


1319-1338
1449
GGCCAUUGCACUCUGCUCU
1450
GGccAuuGcAcucuGcucudTsdT
sense


 


1319-1338
1451
AGAGCAGAGUGCAAUGGCC
1452
AGAGcAGAGUGcAAUGGCCdTsdT
antis


 


1349-1368
1453
GUACACGCCAUCCUCAAGG
1454
GuAcAcGccAuccucAAGGdTsdT
sense


 


1349-1368
1455
CCUUGAGGAUGGCGUGUAC
1456
CCUUGAGGAUGGCGUGuACdTsdT
antis


 


1409-1428
1457
ACUGCGGAGACUCGGAGCC
1458
AcuGcGGAGAcucGGAGccdTsdT
sense


 


1409-1428
1459
GGCUCCGAGUCUCCGCAGU
1460
GGCUCCGAGUCUCCGcAGUdTsdT
antis


 


1410-1429
1461
CUGCGGAGACUCGGAGCCC
1462
cuGcGGAGAcucGGAGcccdTsdT
sense


 


1410-1429
1463
GGGCUCCGAGUCUCCGCAG
1464
GGGCUCCGAGUCUCCGcAGdTsdT
antis


 


1448-1467
1465
GCUUCCCCCCCUGUUCAAC
1466
GcuucccccccuGuucAAcdTsdT
sense


 


1448-1467
1467
GUUGAACAGGGGGGGAAGC
1468
GUUGAAcAGGGGGGGAAGCdTsdT
antis


 


1449-1468
1469
CUUCCCCCCCUGUUCAACU
1470
cuucccccccuGuucAAcudTsdT
sense


 


1449-1468
1471
AGUUGAACAGGGGGGGAAG
1472
AGUUGAAcAGGGGGGGAAGdTsdT
antis


 


1450-1469
1473
UUCCCCCCCUGUUCAACUU
1474
uucccccccuGuucAAcuudTsdT
sense


 


1450-1469
1475
AAGUUGAACAGGGGGGGAA
1476
AAGUUGAAcAGGGGGGGAAdTsdT
antis


 


1567-1586
1477
CCUACAACCCAUCCUCACA
1478
ccuAcAAcccAuccucAcAdTsdT
sense


 


1567-1586
1479
UGUGAGGAUGGGUUGUAGG
1480
UGUGAGGAUGGGUUGuAGGdTsdT
antis


 


1583-1602
1481
ACAAGCUUUAACUGAAGCU
1482
AcAAGcuuuAAcuGAAGcudTsdT
sense


 


1583-1602
1483
AGCUUCAGUUAAAGCUUGU
1484
AGCUUcAGUuAAAGCUUGUdTsdT
antis


 


1596-1615
1485
GAAGCUCAGACUGGCCAAG
1486
GAAGcucAGAcuGGccAAGdTsdT
sense


 


1596-1615
1487
CUUGGCCAGUCUGAGCUUC
1488
CUUGGCcAGUCUGAGCUUCdTsdT
antis


 


1608-1627
1489
GGCCAAGAUUGGCAGCCAU
1490
GGccAAGAuuGGcAGccAudTsdT
sense


 


1608-1627
1491
AUGGCUGCCAAUCUUGGCC
1492
AUGGCUGCcAAUCUUGGCCdTsdT
antis


 


1638-1657
1493
ACUGCUACCCUCGCUAGCU
1494
AcuGcuAcccucGcuAGcudTsdT
sense


 


1638-1657
1495
AGCUAGCGAGGGUAGCAGU
1496
AGCuAGCGAGGGuAGcAGUdTsdT
antis


 


1854-1873
1497
UUAACUGUUUGUAGGGGAG
1498
uuAAcuGuuuGuAGGGGAGdTsdT
sense


 


1854-1873
1499
CUCCCCUACAAACAGUUAA
1500
CUCCCCuAcAAAcAGUuAAdTsdT
antis


 


1980-1999
1501
CUUGUAAAUAGAACCAGCC
1502
cuuGuAAAuAGAAccAGccdTsdT
sense


 


1980-1999
1503
GGCUGGUUCUAUUUACAAG
1504
GGCUGGUUCuAUUuAcAAGdTsdT
antis


 


2034-2053
1505
GGGUGUAAAUAGAUUGUUA
1506
GGGuGuAAAuAGAuuGuuAdTsdT
sense


 


2034-2053
1507
UAACAAUCUAUUUACACCC
1508
uAAcAAUCuAUUuAcACCCdTsdT
antis


 


2037-2056
1509
UGUAAAUAGAUUGUUAUAA
1510
uGuAAAuAGAuuGuuAuAAdTsdT
sense


 


2037-2056
1511
UUAUAACAAUCUAUUUACA
1512
UuAuAAcAAUCuAUUuAcAdTsdT
antis


 


2087-2106
1513
AUUCAACUUGCCCCCCCCA
1514
AuucAAcuuGccccccccAdTsdT
sense


 


2087-2106
1515
UGGGGGGGGCAAGUUGAAU
1516
UGGGGGGGGcAAGUUGAAUdTsdT
antis


 


2088-2107
1517
UUCAACUUGCCCCCCCCAG
1518
uucAAcuuGccccccccAGdTsdT
sense


 


2088-2107
1519
CUGGGGGGGGCAAGUUGAA
1520
CUGGGGGGGGcAAGUUGAAdTsdT
antis


 


2171-2190
1521
GUAGAGAGAGUCCCUGGUG
1522
GuAGAGAGAGucccuGGuGdTsdT
sense


 


2171-2190
1523
CACCAGGGACUCUCUCUAC
1524
cACcAGGGACUCUCUCuACdTsdT
antis


 


2212-2231
1525
UGCCUGUGUACAGACCUCU
1526
uGccuGuGuAcAGAccucudTsdT
sense


 


2212-2231
1527
AGAGGUCUGUACACAGGCA
1528
AGAGGUCUGuAcAcAGGcAdTsdT
antis


 


2221-2240
1529
ACAGACCUCUGUUCAAUAA
1530
AcAGAccucuGuucAAuAAdTsdT
sense


 


2221-2240
1531
UUAUUGAACAGAGGUCUGU
1532
UuAUUGAAcAGAGGUCUGUdTsdT
antis


 


190-209
1533
CCAUGAGCGGCGGCGGGCC
1534
ccAuGAGcGGcGGcGGGccdTsdT
sense


 


190-209
1535
GGCCCGCCGCCGCUCAUGG
1536
GGCCCGCCGCCGCUcAUGGdTsdT
antis


 


377-396
1537
CUCGAGCUCCGGGGGUGGC
1538
cucGAGcuccGGGGGuGGcdTsdT
sense


 


377-396
1539
GCCACCCCCGGAGCUCGAG
1540
GCcACCCCCGGAGCUCGAGdTsdT
antis


 


469-488
1541
UGGGCCGUGACAGCGGGAA
1542
uGGGccGuGAcAGcGGGAAdTsdT
sense


 


469-488
1543
UUCCCGCUGUCACGGCCCA
1544
UUCCCGCUGUcACGGCCcAdTsdT
antis


 


590-609
1545
AUACCAGGCACGGCUGGCA
1546
AuAccAGGcAcGGcuGGcAdTsdT
sense


 


590-609
1547
UGCCAGCCGUGCCUGGUAU
1548
UGCcAGCCGUGCCUGGuAUdTsdT
antis


 


658-677
1549
UCAAGAACCGAGAACUGCA
1550
ucAAGAAccGAGAAcuGcAdTsdT
sense


 


658-677
1551
UGCAGUUCUCGGUUCUUGA
1552
UGcAGUUCUCGGUUCUUGAdTsdT
antis


 


 998-1017
1553
GCUGGUUCGGGGGGAGCCC
1554
GcuGGuucGGGGGGAGcccdTsdT
sense


 


 998-1017
1555
GGGCUCCCCCCGAACCAGC
1556
GGGCUCCCCCCGAACcAGCdTsdT
antis


 


 999-1018
1557
CUGGUUCGGGGGGAGCCCA
1558
cuGGuucGGGGGGAGcccAdTsdT
sense


 


 999-1018
1559
UGGGCUCCCCCCGAACCAG
1560
UGGGCUCCCCCCGAACcAGdTsdT
antis


 


1025-1044
1561
CUACAUCUGCUCUCGGUAC
1562
cuAcAucuGcucucGGuAcdTsdT
sense


 


1025-1044
1563
GUACCGAGAGCAGAUGUAG
1564
GuACCGAGAGcAGAUGuAGdTsdT
antis


 


1327-1346
1565
CACUCUGCUCUAGCCUACU
1566
cAcucuGcucuAGccuAcudTsdT
sense


 


1327-1346
1567
AGUAGGCUAGAGCAGAGUG
1568
AGuAGGCuAGAGcAGAGUGdTsdT
antis


 


1417-1436
1569
GACUCGGAGCCCAGCUCCC
1570
GAcucGGAGcccAGcucccdTsdT
sense


 


1417-1436
1571
GGGAGCUGGGCUCCGAGUC
1572
GGGAGCUGGGCUCCGAGUCdTsdT
antis


 


1594-1613
1573
CUGAAGCUCAGACUGGCCA
1574
cuGAAGcucAGAcuGGccAdTsdT
sense


 


1594-1613
1575
UGGCCAGUCUGAGCUUCAG
1576
UGGCcAGUCUGAGCUUcAGdTsdT
antis


 


2213-2232
1577
GCCUGUGUACAGACCUCUG
1578
GccuGuGuAcAGAccucuGdTsdT
sense


 


2213-2232
1579
CAGAGGUCUGUACACAGGC
1580
cAGAGGUCUGuAcAcAGGCdTsdT
antis


 


1451-1470
1581
UCCCCCCCUGUUCAACUUC
1582
ucccccccuGuucAAcuucdTsdT
sense


 


1451-1470
1583
GAAGUUGAACAGGGGGGGA
1584
GAAGUUGAAcAGGGGGGGAdTsdT
antis


 


1563-1582
1585
ACUUCCUACAACCCAUCCU
1586
AcuuccuAcAAcccAuccudTsdT
sense


 


1563-1582
1587
AGGAUGGGUUGUAGGAAGU
1588
AGGAUGGGUUGuAGGAAGUdTsdT
antis


 


1607-1626
1589
UGGCCAAGAUUGGCAGCCA
1590
uGGccAAGAuuGGcAGccAdTsdT
sense


 


1607-1626
1591
UGGCUGCCAAUCUUGGCCA
1592
UGGCUGCcAAUCUUGGCcAdTsdT
antis


 


1939-1958
1593
CCCAGGCUACCACUCCUUC
1594
cccAGGcuAccAcuccuucdTsdT
sense


 


1939-1958
1595
GAAGGAGUGGUAGCCUGGG
1596
GAAGGAGUGGuAGCCUGGGdTsdT
antis


 


74-93
1597
CGGAGCCCGAACGGCGCGG
1598
cGGAGcccGAAcGGcGcGGdTsdT
sense


 


74-93
1599
CCGCGCCGUUCGGGCUCCG
1600
CCGCGCCGUUCGGGCUCCGdTsdT
antis


 


75-94
1601
GGAGCCCGAACGGCGCGGC
1602
GGAGcccGAAcGGcGcGGcdTsdT
sense


 


75-94
1603
GCCGCGCCGUUCGGGCUCC
1604
GCCGCGCCGUUCGGGCUCCdTsdT
antis


 


 85-104
1605
CGGCGCGGCCUGGAAGAGG
1606
cGGcGcGGccuGGAAGAGGdTsdT
sense


 


 85-104
1607
CCUCUUCCAGGCCGCGCCG
1608
CCUCUUCcAGGCCGCGCCGdTsdT
antis


 


 86-105
1609
GGCGCGGCCUGGAAGAGGC
1610
GGcGcGGccuGGAAGAGGcdTsdT
sense


 


 86-105
1611
GCCUCUUCCAGGCCGCGCC
1612
GCCUCUUCcAGGCCGCGCCdTsdT
antis


 


203-222
1613
CGGGCCUUCGGGAGGCGGC
1614
cGGGccuucGGGAGGcGGcdTsdT
sense


 


203-222
1615
GCCGCCUCCCGAAGGCCCG
1616
GCCGCCUCCCGAAGGCCCGdTsdT
antis


 


206-225
1617
GCCUUCGGGAGGCGGCCCU
1618
GccuucGGGAGGcGGcccudTsdT
sense


 


206-225
1619
AGGGCCGCCUCCCGAAGGC
1620
AGGGCCGCCUCCCGAAGGCdTsdT
antis


 


208-227
1621
CUUCGGGAGGCGGCCCUGG
1622
cuucGGGAGGcGGcccuGGdTsdT
sense


 


208-227
1623
CCAGGGCCGCCUCCCGAAG
1624
CcAGGGCCGCCUCCCGAAGdTsdT
antis


 


245-264
1625
GACCAGCUCGUUCGCGGAG
1626
GAccAGcucGuucGcGGAGdTsdT
sense


 


245-264
1627
CUCCGCGAACGAGCUGGUC
1628
CUCCGCGAACGAGCUGGUCdTsdT
antis


 


448-467
1629
UCCCGCCGCCGGGAGUGAA
1630
ucccGccGccGGGAGuGAAdTsdT
sense


 


448-467
1631
UUCACUCCCGGCGGCGGGA
1632
UUcACUCCCGGCGGCGGGAdTsdT
antis


 


452-471
1633
GCCGCCGGGAGUGAAGCUG
1634
GccGccGGGAGuGAAGcuGdTsdT
sense


 


452-471
1635
CAGCUUCACUCCCGGCGGC
1636
cAGCUUcACUCCCGGCGGCdTsdT
antis


 


453-472
1637
CCGCCGGGAGUGAAGCUGG
1638
ccGccGGGAGuGAAGcuGGdTsdT
sense


 


453-472
1639
CCAGCUUCACUCCCGGCGG
1640
CcAGCUUcACUCCCGGCGGdTsdT
antis


 


470-489
1641
GGGCCGUGACAGCGGGAAG
1642
GGGccGuGAcAGcGGGAAGdTsdT
sense


 


470-489
1643
CUUCCCGCUGUCACGGCCC
1644
CUUCCCGCUGUcACGGCCCdTsdT
antis


 


588-607
1645
GUAUACCAGGCACGGCUGG
1646
GuAuAccAGGcAcGGcuGGdTsdT
sense


 


588-607
1647
CCAGCCGUGCCUGGUAUAC
1648
CcAGCCGUGCCUGGuAuACdTsdT
antis


 


609-628
1649
GAGACGAGGGAACUGGUGG
1650
GAGAcGAGGGAAcuGGuGGdTsdT
sense


 


609-628
1651
CCACCAGUUCCCUCGUCUC
1652
CcACcAGUUCCCUCGUCUCdTsdT
antis


 


611-630
1653
GACGAGGGAACUGGUGGCC
1654
GAcGAGGGAAcuGGuGGccdTsdT
sense


 


611-630
1655
GGCCACCAGUUCCCUCGUC
1656
GGCcACcAGUUCCCUCGUCdTsdT
antis


 


649-668
1657
ACAAAAGGUUCAAGAACCG
1658
AcAAAAGGuucAAGAAccGdTsdT
sense


 


649-668
1659
CGGUUCUUGAACCUUUUGU
1660
CGGUUCUUGAACCUUUUGUdTsdT
antis


 


652-671
1661
AAAGGUUCAAGAACCGAGA
1662
AAAGGuucAAGAAccGAGAdTsdT
sense


 


652-671
1663
UCUCGGUUCUUGAACCUUU
1664
UCUCGGUUCUUGAACCUUUdTsdT
antis


 


653-672
1665
AAGGUUCAAGAACCGAGAA
1666
AAGGuucAAGAAccGAGAAdTsdT
sense


 


653-672
1667
UUCUCGGUUCUUGAACCUU
1668
UUCUCGGUUCUUGAACCUUdTsdT
antis


 


742-761
1669
AGAAGAAGGACGAGCUGUA
1670
AGAAGAAGGAcGAGcuGuAdTsdT
sense


 


742-761
1671
UACAGCUCGUCCUUCUUCU
1672
uAcAGCUCGUCCUUCUUCUdTsdT
antis


 


744-763
1673
AAGAAGGACGAGCUGUAUU
1674
AAGAAGGAcGAGcuGuAuudTsdT
sense


 


744-763
1675
AAUACAGCUCGUCCUUCUU
1676
AAuAcAGCUCGUCCUUCUUdTsdT
antis


 


790-809
1677
AGACGGUGUACCGAGUGGC
1678
AGAcGGuGuAccGAGuGGcdTsdT
sense


 


790-809
1679
GCCACUCGGUACACCGUCU
1680
GCcACUCGGuAcACCGUCUdTsdT
antis


 


840-859
1681
CCUAUCAUCUACAUCAAGG
1682
ccuAucAucuAcAucAAGGdTsdT
sense


 


840-859
1683
CCUUGAUGUAGAUGAUAGG
1684
CCUUGAUGuAGAUGAuAGGdTsdT
antis


 


882-901
1685
AGCUUGGCCUACAUCCACU
1686
AGcuuGGccuAcAuccAcudTsdT
sense


 


882-901
1687
AGUGGAUGUAGGCCAAGCU
1688
AGUGGAUGuAGGCcAAGCUdTsdT
antis


 


912-931
1689
UGUCACCGUGACAUCAAGC
1690
uGucAccGuGAcAucAAGcdTsdT
sense


 


912-931
1691
GCUUGAUGUCACGGUGACA
1692
GCUUGAUGUcACGGUGAcAdTsdT
antis


 


947-966
1693
GGACCCUGACACUGCUGUC
1694
GGAcccuGAcAcuGcuGucdTsdT
sense


 


947-966
1695
GACAGCAGUGUCAGGGUCC
1696
GAcAGcAGUGUcAGGGUCCdTsdT
antis


 


1009-1028
1697
GGGAGCCCAAUGUGUCCUA
1698
GGGAGcccAAuGuGuccuAdTsdT
sense


 


1009-1028
1699
UAGGACACAUUGGGCUCCC
1700
uAGGAcAcAUUGGGCUCCCdTsdT
antis


 


1017-1036
1701
AAUGUGUCCUACAUCUGCU
1702
AAuGuGuccuAcAucuGcudTsdT
sense


 


1017-1036
1703
AGCAGAUGUAGGACACAUU
1704
AGcAGAUGuAGGAcAcAUUdTsdT
antis


 


1113-1132
1705
UGUGUACUUGCUGAGCUAC
1706
uGuGuAcuuGcuGAGcuAcdTsdT
sense


 


1113-1132
1707
GUAGCUCAGCAAGUACACA
1708
GuAGCUcAGcAAGuAcAcAdTsdT
antis


 


1121-1140
1709
UGCUGAGCUACUUCUCGGC
1710
uGcuGAGcuAcuucucGGcdTsdT
sense


 


1121-1140
1711
GCCGAGAAGUAGCUCAGCA
1712
GCCGAGAAGuAGCUcAGcAdTsdT
antis


 


1268-1287
1713
CAAAGCUCACCCUUGGACA
1714
cAAAGcucAcccuuGGAcAdTsdT
sense


 


1268-1287
1715
UGUCCAAGGGUGAGCUUUG
1716
UGUCcAAGGGUGAGCUUUGdTsdT
antis


 


1290-1309
1717
GUGUUCAAAUCUUCAAAGA
1718
GuGuucAAAucuucAAAGAdTsdT
sense


 


1290-1309
1719
UCUUUGAAGAUUUGAACAC
1720
UCUUUGAAGAUUUGAAcACdTsdT
antis


 


1308-1327
1721
ACACCACCUGAGGCCAUUG
1722
AcAccAccuGAGGccAuuGdTsdT
sense


 


1308-1327
1723
CAAUGGCCUCAGGUGGUGU
1724
cAAUGGCCUcAGGUGGUGUdTsdT
antis


 


1312-1331
1725
CACCUGAGGCCAUUGCACU
1726
cAccuGAGGccAuuGcAcudTsdT
sense


 


1312-1331
1727
AGUGCAAUGGCCUCAGGUG
1728
AGUGcAAUGGCCUcAGGUGdTsdT
antis


 


1326-1345
1729
GCACUCUGCUCUAGCCUAC
1730
GcAcucuGcucuAGccuAcdTsdT
sense


 


1326-1345
1731
GUAGGCUAGAGCAGAGUGC
1732
GuAGGCuAGAGcAGAGUGCdTsdT
antis


 


1332-1351
1733
UGCUCUAGCCUACUGGAGU
1734
uGcucuAGccuAcuGGAGudTsdT
sense


 


1332-1351
1735
ACUCCAGUAGGCUAGAGCA
1736
ACUCcAGuAGGCuAGAGcAdTsdT
antis


 


1406-1425
1737
UGAACUGCGGAGACUCGGA
1738
uGAAcuGcGGAGAcucGGAdTsdT
sense


 


1406-1425
1739
UCCGAGUCUCCGCAGUUCA
1740
UCCGAGUCUCCGcAGUUcAdTsdT
antis


 


1407-1426
1741
GAACUGCGGAGACUCGGAG
1742
GAAcuGcGGAGAcucGGAGdTsdT
sense


 


1407-1426
1743
CUCCGAGUCUCCGCAGUUC
1744
CUCCGAGUCUCCGcAGUUCdTsdT
antis


 


1415-1434
1745
GAGACUCGGAGCCCAGCUC
1746
GAGAcucGGAGcccAGcucdTsdT
sense


 


1415-1434
1747
GAGCUGGGCUCCGAGUCUC
1748
GAGCUGGGCUCCGAGUCUCdTsdT
antis


 


1464-1483
1749
AACUUCAGUCCUGGUGAAC
1750
AAcuucAGuccuGGuGAAcdTsdT
sense


 


1464-1483
1751
GUUCACCAGGACUGAAGUU
1752
GUUcACcAGGACUGAAGUUdTsdT
antis


 


1465-1484
1753
ACUUCAGUCCUGGUGAACU
1754
AcuucAGuccuGGuGAAcudTsdT
sense


 


1465-1484
1755
AGUUCACCAGGACUGAAGU
1756
AGUUcACcAGGACUGAAGUdTsdT
antis


 


1479-1498
1757
GAACUGUCCAUCCAACCAU
1758
GAAcuGuccAuccAAccAudTsdT
sense


 


1479-1498
1759
AUGGUUGGAUGGACAGUUC
1760
AUGGUUGGAUGGAcAGUUCdTsdT
antis


 


1566-1585
1761
UCCUACAACCCAUCCUCAC
1762
uccuAcAAcccAuccucAcdTsdT
sense


 


1566-1585
1763
GUGAGGAUGGGUUGUAGGA
1764
GUGAGGAUGGGUUGuAGGAdTsdT
antis


 


1571-1590
1765
CAACCCAUCCUCACAAGCU
1766
cAAcccAuccucAcAAGcudTsdT
sense


 


1571-1590
1767
AGCUUGUGAGGAUGGGUUG
1768
AGCUUGUGAGGAUGGGUUGdTsdT
antis


 


1584-1603
1769
CAAGCUUUAACUGAAGCUC
1770
cAAGcuuuAAcuGAAGcucdTsdT
sense


 


1584-1603
1771
GAGCUUCAGUUAAAGCUUG
1772
GAGCUUcAGUuAAAGCUUGdTsdT
antis


 


1802-1821
1773
CUAGGCCUCCCUCAGCAGC
1774
cuAGGccucccucAGcAGcdTsdT
sense


 


1802-1821
1775
GCUGCUGAGGGAGGCCUAG
1776
GCUGCUGAGGGAGGCCuAGdTsdT
antis


 


1938-1957
1777
CCCCAGGCUACCACUCCUU
1778
ccccAGGcuAccAcuccuudTsdT
sense


 


1938-1957
1779
AAGGAGUGGUAGCCUGGGG
1780
AAGGAGUGGuAGCCUGGGGdTsdT
antis


 


1986-2005
1781
AAUAGAACCAGCCCAGCCC
1782
AAuAGAAccAGcccAGcccdTsdT
sense


 


1986-2005
1783
GGGCUGGGCUGGUUCUAUU
1784
GGGCUGGGCUGGUUCuAUUdTsdT
antis


 


1987-2006
1785
AUAGAACCAGCCCAGCCCA
1786
AuAGAAccAGcccAGcccAdTsdT
sense


 


1987-2006
1787
UGGGCUGGGCUGGUUCUAU
1788
UGGGCUGGGCUGGUUCuAUdTsdT
antis


 


2032-2051
1789
CUGGGUGUAAAUAGAUUGU
1790
cuGGGuGuAAAuAGAuuGudTsdT
sense


 


2032-2051
1791
ACAAUCUAUUUACACCCAG
1792
AcAAUCuAUUuAcACCcAGdTsdT
antis


 


2085-2104
1793
CCAUUCAACUUGCCCCCCC
1794
ccAuucAAcuuGcccccccdTsdT
sense


 


2085-2104
1795
GGGGGGGCAAGUUGAAUGG
1796
GGGGGGGcAAGUUGAAUGGdTsdT
antis


 


2090-2109
1797
CAACUUGCCCCCCCCAGCU
1798
cAAcuuGccccccccAGcudTsdT
sense


 


2090-2109
1799
AGCUGGGGGGGGCAAGUUG
1800
AGCUGGGGGGGGcAAGUUGdTsdT
antis


 


2094-2113
1801
UUGCCCCCCCCAGCUGUAC
1802
uuGccccccccAGcuGuAcdTsdT
sense


 


2094-2113
1803
GUACAGCUGGGGGGGGCAA
1804
GuAcAGCUGGGGGGGGcAAdTsdT
antis


 


2101-2120
1805
CCCCAGCUGUACCCCUUCU
1806
ccccAGcuGuAccccuucudTsdT
sense


 


2101-2120
1807
AGAAGGGGUACAGCUGGGG
1808
AGAAGGGGuAcAGCUGGGGdTsdT
antis


 


2104-2123
1809
CAGCUGUACCCCUUCUUGU
1810
cAGcuGuAccccuucuuGudTsdT
sense


 


2104-2123
1811
ACAAGAAGGGGUACAGCUG
1812
AcAAGAAGGGGuAcAGCUGdTsdT
antis


 


2105-2124
1813
AGCUGUACCCCUUCUUGUC
1814
AGcuGuAccccuucuuGucdTsdT
sense


 


2105-2124
1815
GACAAGAAGGGGUACAGCU
1816
GAcAAGAAGGGGuAcAGCUdTsdT
antis


 


2155-2174
1817
UCCUGGAAGGAGGGGAGUA
1818
uccuGGAAGGAGGGGAGuAdTsdT
sense


 


2155-2174
1819
UACUCCCCUCCUUCCAGGA
1820
uACUCCCCUCCUUCcAGGAdTsdT
antis


 


2167-2186
1821
GGGAGUAGAGAGAGUCCCU
1822
GGGAGuAGAGAGAGucccudTsdT
sense


 


2167-2186
1823
AGGGACUCUCUCUACUCCC
1824
AGGGACUCUCUCuACUCCCdTsdT
antis


 


2174-2193
1825
GAGAGAGUCCCUGGUGUCU
1826
GAGAGAGucccuGGuGucudTsdT
sense


 


2174-2193
1827
AGACACCAGGGACUCUCUC
1828
AGAcACcAGGGACUCUCUCdTsdT
antis


 


2216-2235
1829
UGUGUACAGACCUCUGUUC
1830
uGuGuAcAGAccucuGuucdTsdT
sense


 


2216-2235
1831
GAACAGAGGUCUGUACACA
1832
GAAcAGAGGUCUGuAcAcAdTsdT
antis


 


2217-2236
1833
GUGUACAGACCUCUGUUCA
1834
GuGuAcAGAccucuGuucAdTsdT
sense


 


2217-2236
1835
UGAACAGAGGUCUGUACAC
1836
UGAAcAGAGGUCUGuAcACdTsdT
antis


 


2236-2255
1837
AUAAAUUAUUGGCAUGAAA
1838
AuAAAuuAuuGGcAuGAAAdTsdT
sense


 


2236-2255
1839
UUUCAUGCCAAUAAUUUAU
1840
UUUcAUGCcAAuAAUUuAUdTsdT
antis


 


2237-2256
1841
UAAAUUAUUGGCAUGAAAC
1842
uAAAuuAuuGGcAuGAAAcdTsdT
sense


 


2237-2256
1843
GUUUCAUGCCAAUAAUUUA
1844
GUUUcAUGCcAAuAAUUuAdTsdT
antis


 


2245-2264
1845
UGGCAUGAAACCCUUAAAA
1846
uGGcAuGAAAcccuuAAAAdTsdT
sense


 


2245-2264
1847
UUUUAAGGGUUUCAUGCCA
1848
UUUuAAGGGUUUcAUGCcAdTsdT
antis


 


13-32
1849
AAGCCGACGGCAGAGGGAC
1850
AAGccGAcGGcAGAGGGAcdTsdT
sense


 


13-32
1851
GUCCCUCUGCCGUCGGCUU
1852
GUCCCUCUGCCGUCGGCUUdTsdT
antis


 


21-40
1853
GGCAGAGGGACUUCAUCUC
1854
GGcAGAGGGAcuucAucucdTsdT
sense


 


21-40
1855
GAGAUGAAGUCCCUCUGCC
1856
GAGAUGAAGUCCCUCUGCCdTsdT
antis


 


22-41
1857
GCAGAGGGACUUCAUCUCC
1858
GcAGAGGGAcuucAucuccdTsdT
sense


 


22-41
1859
GGAGAUGAAGUCCCUCUGC
1860
GGAGAUGAAGUCCCUCUGCdTsdT
antis


 


23-42
1861
CAGAGGGACUUCAUCUCCC
1862
cAGAGGGAcuucAucucccdTsdT
sense


 


23-42
1863
GGGAGAUGAAGUCCCUCUG
1864
GGGAGAUGAAGUCCCUCUGdTsdT
antis


 


25-44
1865
GAGGGACUUCAUCUCCCGG
1866
GAGGGAcuucAucucccGGdTsdT
sense


 


25-44
1867
CCGGGAGAUGAAGUCCCUC
1868
CCGGGAGAUGAAGUCCCUCdTsdT
antis


 


30-49
1869
ACUUCAUCUCCCGGCGUGC
1870
AcuucAucucccGGcGuGcdTsdT
sense


 


30-49
1871
GCACGCCGGGAGAUGAAGU
1872
GcACGCCGGGAGAUGAAGUdTsdT
antis


 


31-50
1873
CUUCAUCUCCCGGCGUGCC
1874
cuucAucucccGGcGuGccdTsdT
sense


 


31-50
1875
GGCACGCCGGGAGAUGAAG
1876
GGcACGCCGGGAGAUGAAGdTsdT
antis


 


32-51
1877
UUCAUCUCCCGGCGUGCCC
1878
uucAucucccGGcGuGcccdTsdT
sense


 


32-51
1879
GGGCACGCCGGGAGAUGAA
1880
GGGcACGCCGGGAGAUGAAdTsdT
antis


 


36-55
1881
UCUCCCGGCGUGCCCCGCG
1882
ucucccGGcGuGccccGcGdTsdT
sense


 


36-55
1883
CGCGGGGCACGCCGGGAGA
1884
CGCGGGGcACGCCGGGAGAdTsdT
antis


 


41-60
1885
CGGCGUGCCCCGCGGCGGG
1886
cGGcGuGccccGcGGcGGGdTsdT
sense


 


41-60
1887
CCCGCCGCGGGGCACGCCG
1888
CCCGCCGCGGGGcACGCCGdTsdT
antis


 


44-63
1889
CGUGCCCCGCGGCGGGCGC
1890
cGuGccccGcGGcGGGcGcdTsdT
sense


 


44-63
1891
GCGCCCGCCGCGGGGCACG
1892
GCGCCCGCCGCGGGGcACGdTsdT
antis


 


45-64
1893
GUGCCCCGCGGCGGGCGCU
1894
GuGccccGcGGcGGGcGcudTsdT
sense


 


45-64
1895
AGCGCCCGCCGCGGGGCAC
1896
AGCGCCCGCCGCGGGGcACdTsdT
antis


 


52-71
1897
GCGGCGGGCGCUGGGCCGG
1898
GcGGcGGGcGcuGGGccGGdTsdT
sense


 


52-71
1899
CCGGCCCAGCGCCCGCCGC
1900
CCGGCCcAGCGCCCGCCGCdTsdT
antis


 


58-77
1901
GGCGCUGGGCCGGAGCCGG
1902
GGcGcuGGGccGGAGccGGdTsdT
sense


 


58-77
1903
CCGGCUCCGGCCCAGCGCC
1904
CCGGCUCCGGCCcAGCGCCdTsdT
antis


 


 84-103
1905
ACGGCGCGGCCUGGAAGAG
1906
AcGGcGcGGccuGGAAGAGdTsdT
sense


 


 84-103
1907
CUCUUCCAGGCCGCGCCGU
1908
CUCUUCcAGGCCGCGCCGUdTsdT
antis


 


 88-107
1909
CGCGGCCUGGAAGAGGCCG
1910
cGcGGccuGGAAGAGGccGdTsdT
sense


 


 88-107
1911
CGGCCUCUUCCAGGCCGCG
1912
CGGCCUCUUCcAGGCCGCGdTsdT
antis


 


 94-113
1913
CUGGAAGAGGCCGGAGCCC
1914
cuGGAAGAGGccGGAGcccdTsdT
sense


 


 94-113
1915
GGGCUCCGGCCUCUUCCAG
1916
GGGCUCCGGCCUCUUCcAGdTsdT
antis


 


 98-117
1917
AAGAGGCCGGAGCCCAGGG
1918
AAGAGGccGGAGcccAGGGdTsdT
sense


 


 98-117
1919
CCCUGGGCUCCGGCCUCUU
1920
CCCUGGGCUCCGGCCUCUUdTsdT
antis


 


100-119
1921
GAGGCCGGAGCCCAGGGGA
1922
GAGGccGGAGcccAGGGGAdTsdT
sense


 


100-119
1923
UCCCCUGGGCUCCGGCCUC
1924
UCCCCUGGGCUCCGGCCUCdTsdT
antis


 


144-163
1925
GCAGCCCAGGCAGCCCGAG
1926
GcAGcccAGGcAGcccGAGdTsdT
sense


 


144-163
1927
CUCGGGCUGCCUGGGCUGC
1928
CUCGGGCUGCCUGGGCUGCdTsdT
antis


 


145-164
1929
CAGCCCAGGCAGCCCGAGC
1930
cAGcccAGGcAGcccGAGcdTsdT
sense


 


145-164
1931
GCUCGGGCUGCCUGGGCUG
1932
GCUCGGGCUGCCUGGGCUGdTsdT
antis


 


148-167
1933
CCCAGGCAGCCCGAGCCCC
1934
cccAGGcAGcccGAGccccdTsdT
sense


 


148-167
1935
GGGGCUCGGGCUGCCUGGG
1936
GGGGCUCGGGCUGCCUGGGdTsdT
antis


 


149-168
1937
CCAGGCAGCCCGAGCCCCG
1938
ccAGGcAGcccGAGccccGdTsdT
sense


 


149-168
1939
CGGGGCUCGGGCUGCCUGG
1940
CGGGGCUCGGGCUGCCUGGdTsdT
antis


 


157-176
1941
CCCGAGCCCCGCGGCCUGG
1942
cccGAGccccGcGGccuGGdTsdT
sense


 


157-176
1943
CCAGGCCGCGGGGCUCGGG
1944
CcAGGCCGCGGGGCUCGGGdTsdT
antis


 


168-187
1945
CGGCCUGGGCCUGCGCUCG
1946
cGGccuGGGccuGcGcucGdTsdT
sense


 


168-187
1947
CGAGCGCAGGCCCAGGCCG
1948
CGAGCGcAGGCCcAGGCCGdTsdT
antis


 


169-188
1949
GGCCUGGGCCUGCGCUCGG
1950
GGccuGGGccuGcGcucGGdTsdT
sense


 


169-188
1951
CCGAGCGCAGGCCCAGGCC
1952
CCGAGCGcAGGCCcAGGCCdTsdT
antis


 


175-194
1953
GGCCUGCGCUCGGCGCCAU
1954
GGccuGcGcucGGcGccAudTsdT
sense


 


175-194
1955
AUGGCGCCGAGCGCAGGCC
1956
AUGGCGCCGAGCGcAGGCCdTsdT
antis


 


179-198
1957
UGCGCUCGGCGCCAUGAGC
1958
uGcGcucGGcGccAuGAGcdTsdT
sense


 


179-198
1959
GCUCAUGGCGCCGAGCGCA
1960
GCUcAUGGCGCCGAGCGcAdTsdT
antis


 


192-211
1961
AUGAGCGGCGGCGGGCCUU
1962
AuGAGcGGcGGcGGGccuudTsdT
sense


 


192-211
1963
AAGGCCCGCCGCCGCUCAU
1964
AAGGCCCGCCGCCGCUcAUdTsdT
antis


 


193-212
1965
UGAGCGGCGGCGGGCCUUC
1966
uGAGcGGcGGcGGGccuucdTsdT
sense


 


193-212
1967
GAAGGCCCGCCGCCGCUCA
1968
GAAGGCCCGCCGCCGCUcAdTsdT
antis


 


194-213
1969
GAGCGGCGGCGGGCCUUCG
1970
GAGcGGcGGcGGGccuucGdTsdT
sense


 


194-213
1971
CGAAGGCCCGCCGCCGCUC
1972
CGAAGGCCCGCCGCCGCUCdTsdT
antis


 


195-214
1973
AGCGGCGGCGGGCCUUCGG
1974
AGcGGcGGcGGGccuucGGdTsdT
sense


 


195-214
1975
CCGAAGGCCCGCCGCCGCU
1976
CCGAAGGCCCGCCGCCGCUdTsdT
antis


 


197-216
1977
CGGCGGCGGGCCUUCGGGA
1978
cGGcGGcGGGccuucGGGAdTsdT
sense


 


197-216
1979
UCCCGAAGGCCCGCCGCCG
1980
UCCCGAAGGCCCGCCGCCGdTsdT
antis


 


200-219
1981
CGGCGGGCCUUCGGGAGGC
1982
cGGcGGGccuucGGGAGGcdTsdT
sense


 


200-219
1983
GCCUCCCGAAGGCCCGCCG
1984
GCCUCCCGAAGGCCCGCCGdTsdT
antis


 


246-265
1985
ACCAGCUCGUUCGCGGAGC
1986
AccAGcucGuucGcGGAGcdTsdT
sense


 


246-265
1987
GCUCCGCGAACGAGCUGGU
1988
GCUCCGCGAACGAGCUGGUdTsdT
antis


 


253-272
1989
CGUUCGCGGAGCCAGGAGG
1990
cGuucGcGGAGccAGGAGGdTsdT
sense


 


253-272
1991
CCUCCUGGCUCCGCGAACG
1992
CCUCCUGGCUCCGCGAACGdTsdT
antis


 


257-276
1993
CGCGGAGCCAGGAGGCGGA
1994
cGcGGAGccAGGAGGcGGAdTsdT
sense


 


257-276
1995
UCCGCCUCCUGGCUCCGCG
1996
UCCGCCUCCUGGCUCCGCGdTsdT
antis


 


258-277
1997
GCGGAGCCAGGAGGCGGAG
1998
GcGGAGccAGGAGGcGGAGdTsdT
sense


 


258-277
1999
CUCCGCCUCCUGGCUCCGC
2000
CUCCGCCUCCUGGCUCCGCdTsdT
antis


 


297-316
2001
CCCGGGGGCUCGGCCUCUG
2002
cccGGGGGcucGGccucuGdTsdT
sense


 


297-316
2003
CAGAGGCCGAGCCCCCGGG
2004
cAGAGGCCGAGCCCCCGGGdTsdT
antis


 


298-317
2005
CCGGGGGCUCGGCCUCUGG
2006
ccGGGGGcucGGccucuGGdTsdT
sense


 


298-317
2007
CCAGAGGCCGAGCCCCCGG
2008
CcAGAGGCCGAGCCCCCGGdTsdT
antis


 


321-340
2009
GGAGGCACUGGCGGCGGGA
2010
GGAGGcAcuGGcGGcGGGAdTsdT
sense


 


321-340
2011
UCCCGCCGCCAGUGCCUCC
2012
UCCCGCCGCcAGUGCCUCCdTsdT
antis


 


323-342
2013
AGGCACUGGCGGCGGGAAA
2014
AGGcAcuGGcGGcGGGAAAdTsdT
sense


 


323-342
2015
UUUCCCGCCGCCAGUGCCU
2016
UUUCCCGCCGCcAGUGCCUdTsdT
antis


 


325-344
2017
GCACUGGCGGCGGGAAAGC
2018
GcAcuGGcGGcGGGAAAGcdTsdT
sense


 


325-344
2019
GCUUUCCCGCCGCCAGUGC
2020
GCUUUCCCGCCGCcAGUGCdTsdT
antis


 


326-345
2021
CACUGGCGGCGGGAAAGCG
2022
cAcuGGcGGcGGGAAAGcGdTsdT
sense


 


326-345
2023
CGCUUUCCCGCCGCCAGUG
2024
CGCUUUCCCGCCGCcAGUGdTsdT
antis


 


338-357
2025
GAAAGCGUCAGUCGGGGCU
2026
GAAAGcGucAGucGGGGcudTsdT
sense


 


338-357
2027
AGCCCCGACUGACGCUUUC
2028
AGCCCCGACUGACGCUUUCdTsdT
antis


 


370-389
2029
UGGGAGCCUCGAGCUCCGG
2030
uGGGAGccucGAGcuccGGdTsdT
sense


 


370-389
2031
CCGGAGCUCGAGGCUCCCA
2032
CCGGAGCUCGAGGCUCCcAdTsdT
antis


 


371-390
2033
GGGAGCCUCGAGCUCCGGG
2034
GGGAGccucGAGcuccGGGdTsdT
sense


 


371-390
2035
CCCGGAGCUCGAGGCUCCC
2036
CCCGGAGCUCGAGGCUCCCdTsdT
antis


 


372-391
2037
GGAGCCUCGAGCUCCGGGG
2038
GGAGccucGAGcuccGGGGdTsdT
sense


 


372-391
2039
CCCCGGAGCUCGAGGCUCC
2040
CCCCGGAGCUCGAGGCUCCdTsdT
antis


 


373-392
2041
GAGCCUCGAGCUCCGGGGG
2042
GAGccucGAGcuccGGGGGdTsdT
sense


 


373-392
2043
CCCCCGGAGCUCGAGGCUC
2044
CCCCCGGAGCUCGAGGCUCdTsdT
antis


 


375-394
2045
GCCUCGAGCUCCGGGGGUG
2046
GccucGAGcuccGGGGGuGdTsdT
sense


 


375-394
2047
CACCCCCGGAGCUCGAGGC
2048
cACCCCCGGAGCUCGAGGCdTsdT
antis


 


380-399
2049
GAGCUCCGGGGGUGGCCCC
2050
GAGcuccGGGGGuGGccccdTsdT
sense


 


380-399
2051
GGGGCCACCCCCGGAGCUC
2052
GGGGCcACCCCCGGAGCUCdTsdT
antis


 


385-404
2053
CCGGGGGUGGCCCCAGCGG
2054
ccGGGGGuGGccccAGcGGdTsdT
sense


 


385-404
2055
CCGCUGGGGCCACCCCCGG
2056
CCGCUGGGGCcACCCCCGGdTsdT
antis


 


389-408
2057
GGGUGGCCCCAGCGGCAGC
2058
GGGuGGccccAGcGGcAGcdTsdT
sense


 


389-408
2059
GCUGCCGCUGGGGCCACCC
2060
GCUGCCGCUGGGGCcACCCdTsdT
antis


 


439-458
2061
GCACUAGCUUCCCGCCGCC
2062
GcAcuAGcuucccGccGccdTsdT
sense


 


439-458
2063
GGCGGCGGGAAGCUAGUGC
2064
GGCGGCGGGAAGCuAGUGCdTsdT
antis


 


440-459
2065
CACUAGCUUCCCGCCGCCG
2066
cAcuAGcuucccGccGccGdTsdT
sense


 


440-459
2067
CGGCGGCGGGAAGCUAGUG
2068
CGGCGGCGGGAAGCuAGUGdTsdT
antis


 


445-464
2069
GCUUCCCGCCGCCGGGAGU
2070
GcuucccGccGccGGGAGudTsdT
sense


 


445-464
2071
ACUCCCGGCGGCGGGAAGC
2072
ACUCCCGGCGGCGGGAAGCdTsdT
antis


 


447-466
2073
UUCCCGCCGCCGGGAGUGA
2074
uucccGccGccGGGAGuGAdTsdT
sense


 


447-466
2075
UCACUCCCGGCGGCGGGAA
2076
UcACUCCCGGCGGCGGGAAdTsdT
antis


 


463-482
2077
UGAAGCUGGGCCGUGACAG
2078
uGAAGcuGGGccGuGAcAGdTsdT
sense


 


463-482
2079
CUGUCACGGCCCAGCUUCA
2080
CUGUcACGGCCcAGCUUcAdTsdT
antis


 


471-490
2081
GGCCGUGACAGCGGGAAGG
2082
GGccGuGAcAGcGGGAAGGdTsdT
sense


 


471-490
2083
CCUUCCCGCUGUCACGGCC
2084
CCUUCCCGCUGUcACGGCCdTsdT
antis


 


474-493
2085
CGUGACAGCGGGAAGGUGA
2086
cGuGAcAGcGGGAAGGuGAdTsdT
sense


 


474-493
2087
UCACCUUCCCGCUGUCACG
2088
UcACCUUCCCGCUGUcACGdTsdT
antis


 


492-511
2089
ACCACAGUGGUAGCCACUG
2090
AccAcAGuGGuAGccAcuGdTsdT
sense


 


492-511
2091
CAGUGGCUACCACUGUGGU
2092
cAGUGGCuACcACUGUGGUdTsdT
antis


 


495-514
2093
ACAGUGGUAGCCACUGUAG
2094
AcAGuGGuAGccAcuGuAGdTsdT
sense


 


495-514
2095
CUACAGUGGCUACCACUGU
2096
CuAcAGUGGCuACcACUGUdTsdT
antis


 


496-515
2097
CAGUGGUAGCCACUGUAGG
2098
cAGuGGuAGccAcuGuAGGdTsdT
sense


 


496-515
2099
CCUACAGUGGCUACCACUG
2100
CCuAcAGUGGCuACcACUGdTsdT
antis


 


506-525
2101
CACUGUAGGCCAAGGCCCA
2102
cAcuGuAGGccAAGGcccAdTsdT
sense


 


506-525
2103
UGGGCCUUGGCCUACAGUG
2104
UGGGCCUUGGCCuAcAGUGdTsdT
antis


 


507-526
2105
ACUGUAGGCCAAGGCCCAG
2106
AcuGuAGGccAAGGcccAGdTsdT
sense


 


507-526
2107
CUGGGCCUUGGCCUACAGU
2108
CUGGGCCUUGGCCuAcAGUdTsdT
antis


 


509-528
2109
UGUAGGCCAAGGCCCAGAG
2110
uGuAGGccAAGGcccAGAGdTsdT
sense


 


509-528
2111
CUCUGGGCCUUGGCCUACA
2112
CUCUGGGCCUUGGCCuAcAdTsdT
antis


 


510-529
2113
GUAGGCCAAGGCCCAGAGC
2114
GuAGGccAAGGcccAGAGcdTsdT
sense


 


510-529
2115
GCUCUGGGCCUUGGCCUAC
2116
GCUCUGGGCCUUGGCCuACdTsdT
antis


 


582-601
2117
GGAGUAGUAUACCAGGCAC
2118
GGAGuAGuAuAccAGGcAcdTsdT
sense


 


582-601
2119
GUGCCUGGUAUACUACUCC
2120
GUGCCUGGuAuACuACUCCdTsdT
antis


 


585-604
2121
GUAGUAUACCAGGCACGGC
2122
GuAGuAuAccAGGcAcGGcdTsdT
sense


 


585-604
2123
GCCGUGCCUGGUAUACUAC
2124
GCCGUGCCUGGuAuACuACdTsdT
antis


 


595-614
2125
AGGCACGGCUGGCAGAGAC
2126
AGGcAcGGcuGGcAGAGAcdTsdT
sense


 


595-614
2127
GUCUCUGCCAGCCGUGCCU
2128
GUCUCUGCcAGCCGUGCCUdTsdT
antis


 


596-615
2129
GGCACGGCUGGCAGAGACG
2130
GGcAcGGcuGGcAGAGAcGdTsdT
sense


 


596-615
2131
CGUCUCUGCCAGCCGUGCC
2132
CGUCUCUGCcAGCCGUGCCdTsdT
antis


 


597-616
2133
GCACGGCUGGCAGAGACGA
2134
GcAcGGcuGGcAGAGAcGAdTsdT
sense


 


597-616
2135
UCGUCUCUGCCAGCCGUGC
2136
UCGUCUCUGCcAGCCGUGCdTsdT
antis


 


610-629
2137
AGACGAGGGAACUGGUGGC
2138
AGAcGAGGGAAcuGGuGGcdTsdT
sense


 


610-629
2139
GCCACCAGUUCCCUCGUCU
2140
GCcACcAGUUCCCUCGUCUdTsdT
antis


 


612-631
2141
ACGAGGGAACUGGUGGCCA
2142
AcGAGGGAAcuGGuGGccAdTsdT
sense


 


612-631
2143
UGGCCACCAGUUCCCUCGU
2144
UGGCcACcAGUUCCCUCGUdTsdT
antis


 


614-633
2145
GAGGGAACUGGUGGCCAUC
2146
GAGGGAAcuGGuGGccAucdTsdT
sense


 


614-633
2147
GAUGGCCACCAGUUCCCUC
2148
GAUGGCcACcAGUUCCCUCdTsdT
antis


 


646-665
2149
AGGACAAAAGGUUCAAGAA
2150
AGGAcAAAAGGuucAAGAAdTsdT
sense


 


646-665
2151
UUCUUGAACCUUUUGUCCU
2152
UUCUUGAACCUUUUGUCCUdTsdT
antis


 


661-680
2153
AGAACCGAGAACUGCAGAU
2154
AGAAccGAGAAcuGcAGAudTsdT
sense


 


661-680
2155
AUCUGCAGUUCUCGGUUCU
2156
AUCUGcAGUUCUCGGUUCUdTsdT
antis


 


668-687
2157
AGAACUGCAGAUUAUGCGU
2158
AGAAcuGcAGAuuAuGcGudTsdT
sense


 


668-687
2159
ACGCAUAAUCUGCAGUUCU
2160
ACGcAuAAUCUGcAGUUCUdTsdT
antis


 


669-688
2161
GAACUGCAGAUUAUGCGUA
2162
GAAcuGcAGAuuAuGcGuAdTsdT
sense


 


669-688
2163
UACGCAUAAUCUGCAGUUC
2164
uACGcAuAAUCUGcAGUUCdTsdT
antis


 


703-722
2165
AUAUUGUGAGGCUGCGGUA
2166
AuAuuGuGAGGcuGcGGuAdTsdT
sense


 


703-722
2167
UACCGCAGCCUCACAAUAU
2168
uACCGcAGCCUcAcAAuAUdTsdT
antis


 


704-723
2169
UAUUGUGAGGCUGCGGUAC
2170
uAuuGuGAGGcuGcGGuAcdTsdT
sense


 


704-723
2171
GUACCGCAGCCUCACAAUA
2172
GuACCGcAGCCUcAcAAuAdTsdT
antis


 


705-724
2173
AUUGUGAGGCUGCGGUACU
2174
AuuGuGAGGcuGcGGuAcudTsdT
sense


 


705-724
2175
AGUACCGCAGCCUCACAAU
2176
AGuACCGcAGCCUcAcAAUdTsdT
antis


 


738-757
2177
GGGGAGAAGAAGGACGAGC
2178
GGGGAGAAGAAGGAcGAGcdTsdT
sense


 


738-757
2179
GCUCGUCCUUCUUCUCCCC
2180
GCUCGUCCUUCUUCUCCCCdTsdT
antis


 


824-843
2181
GGCCAAGCUGAUCACCCCU
2182
GGccAAGcuGAucAccccudTsdT
sense


 


824-843
2183
AGGGGUGAUCAGCUUGGCC
2184
AGGGGUGAUcAGCUUGGCCdTsdT
antis


 


827-846
2185
CAAGCUGAUCACCCCUAUC
2186
cAAGcuGAucAccccuAucdTsdT
sense


 


827-846
2187
GAUAGGGGUGAUCAGCUUG
2188
GAuAGGGGUGAUcAGCUUGdTsdT
antis


 


879-898
2189
CGGAGCUUGGCCUACAUCC
2190
cGGAGcuuGGccuAcAuccdTsdT
sense


 


879-898
2191
GGAUGUAGGCCAAGCUCCG
2192
GGAUGuAGGCcAAGCUCCGdTsdT
antis


 


880-899
2193
GGAGCUUGGCCUACAUCCA
2194
GGAGcuuGGccuAcAuccAdTsdT
sense


 


880-899
2195
UGGAUGUAGGCCAAGCUCC
2196
UGGAUGuAGGCcAAGCUCCdTsdT
antis


 


881-900
2197
GAGCUUGGCCUACAUCCAC
2198
GAGcuuGGccuAcAuccAcdTsdT
sense


 


881-900
2199
GUGGAUGUAGGCCAAGCUC
2200
GUGGAUGuAGGCcAAGCUCdTsdT
antis


 


884-903
2201
CUUGGCCUACAUCCACUCC
2202
cuuGGccuAcAuccAcuccdTsdT
sense


 


884-903
2203
GGAGUGGAUGUAGGCCAAG
2204
GGAGUGGAUGuAGGCcAAGdTsdT
antis


 


886-905
2205
UGGCCUACAUCCACUCCCA
2206
uGGccuAcAuccAcucccAdTsdT
sense


 


886-905
2207
UGGGAGUGGAUGUAGGCCA
2208
UGGGAGUGGAUGuAGGCcAdTsdT
antis


 


896-915
2209
CCACUCCCAAGGUGUGUGU
2210
ccAcucccAAGGuGuGuGudTsdT
sense


 


896-915
2211
ACACACACCUUGGGAGUGG
2212
AcAcAcACCUUGGGAGUGGdTsdT
antis


 


916-935
2213
ACCGUGACAUCAAGCCCCA
2214
AccGuGAcAucAAGccccAdTsdT
sense


 


916-935
2215
UGGGGCUUGAUGUCACGGU
2216
UGGGGCUUGAUGUcACGGUdTsdT
antis


 


917-936
2217
CCGUGACAUCAAGCCCCAG
2218
ccGuGAcAucAAGccccAGdTsdT
sense


 


917-936
2219
CUGGGGCUUGAUGUCACGG
2220
CUGGGGCUUGAUGUcACGGdTsdT
antis


 


931-950
2221
CCCAGAAUUUGCUUGUGGA
2222
cccAGAAuuuGcuuGuGGAdTsdT
sense


 


931-950
2223
UCCACAAGCAAAUUCUGGG
2224
UCcAcAAGcAAAUUCUGGGdTsdT
antis


 


933-952
2225
CAGAAUUUGCUUGUGGACC
2226
cAGAAuuuGcuuGuGGAccdTsdT
sense


 


933-952
2227
GGUCCACAAGCAAAUUCUG
2228
GGUCcAcAAGcAAAUUCUGdTsdT
antis


 


 991-1010
2229
CAAAGCAGCUGGUUCGGGG
2230
cAAAGcAGcuGGuucGGGGdTsdT
sense


 


 991-1010
2231
CCCCGAACCAGCUGCUUUG
2232
CCCCGAACcAGCUGCUUUGdTsdT
antis


 


 993-1012
2233
AAGCAGCUGGUUCGGGGGG
2234
AAGcAGcuGGuucGGGGGGdTsdT
sense


 


 993-1012
2235
CCCCCCGAACCAGCUGCUU
2236
CCCCCCGAACcAGCUGCUUdTsdT
antis


 


1000-1019
2237
UGGUUCGGGGGGAGCCCAA
2238
uGGuucGGGGGGAGcccAAdTsdT
sense


 


1000-1019
2239
UUGGGCUCCCCCCGAACCA
2240
UUGGGCUCCCCCCGAACcAdTsdT
antis


 


1003-1022
2241
UUCGGGGGGAGCCCAAUGU
2242
uucGGGGGGAGcccAAuGudTsdT
sense


 


1003-1022
2243
ACAUUGGGCUCCCCCCGAA
2244
AcAUUGGGCUCCCCCCGAAdTsdT
antis


 


1004-1023
2245
UCGGGGGGAGCCCAAUGUG
2246
ucGGGGGGAGcccAAuGuGdTsdT
sense


 


1004-1023
2247
CACAUUGGGCUCCCCCCGA
2248
cAcAUUGGGCUCCCCCCGAdTsdT
antis


 


1006-1025
2249
GGGGGGAGCCCAAUGUGUC
2250
GGGGGGAGcccAAuGuGucdTsdT
sense


 


1006-1025
2251
GACACAUUGGGCUCCCCCC
2252
GAcAcAUUGGGCUCCCCCCdTsdT
antis


 


1015-1034
2253
CCAAUGUGUCCUACAUCUG
2254
ccAAuGuGuccuAcAucuGdTsdT
sense


 


1015-1034
2255
CAGAUGUAGGACACAUUGG
2256
cAGAUGuAGGAcAcAUUGGdTsdT
antis


 


1016-1035
2257
CAAUGUGUCCUACAUCUGC
2258
cAAuGuGuccuAcAucuGcdTsdT
sense


 


1016-1035
2259
GCAGAUGUAGGACACAUUG
2260
GcAGAUGuAGGAcAcAUUGdTsdT
antis


 


1031-1050
2261
CUGCUCUCGGUACUACCGU
2262
cuGcucucGGuAcuAccGudTsdT
sense


 


1031-1050
2263
ACGGUAGUACCGAGAGCAG
2264
ACGGuAGuACCGAGAGcAGdTsdT
antis


 


1045-1064
2265
ACCGUGCUCCAGAACUCAU
2266
AccGuGcuccAGAAcucAudTsdT
sense


 


1045-1064
2267
AUGAGUUCUGGAGCACGGU
2268
AUGAGUUCUGGAGcACGGUdTsdT
antis


 


1047-1066
2269
CGUGCUCCAGAACUCAUCU
2270
cGuGcuccAGAAcucAucudTsdT
sense


 


1047-1066
2271
AGAUGAGUUCUGGAGCACG
2272
AGAUGAGUUCUGGAGcACGdTsdT
antis


 


1051-1070
2273
CUCCAGAACUCAUCUUUGG
2274
cuccAGAAcucAucuuuGGdTsdT
sense


 


1051-1070
2275
CCAAAGAUGAGUUCUGGAG
2276
CcAAAGAUGAGUUCUGGAGdTsdT
antis


 


1055-1074
2277
AGAACUCAUCUUUGGAGCC
2278
AGAAcucAucuuuGGAGccdTsdT
sense


 


1055-1074
2279
GGCUCCAAAGAUGAGUUCU
2280
GGCUCcAAAGAUGAGUUCUdTsdT
antis


 


1058-1077
2281
ACUCAUCUUUGGAGCCACA
2282
AcucAucuuuGGAGccAcAdTsdT
sense


 


1058-1077
2283
UGUGGCUCCAAAGAUGAGU
2284
UGUGGCUCcAAAGAUGAGUdTsdT
antis


 


1061-1080
2285
CAUCUUUGGAGCCACAGAU
2286
cAucuuuGGAGccAcAGAudTsdT
sense


 


1061-1080
2287
AUCUGUGGCUCCAAAGAUG
2288
AUCUGUGGCUCcAAAGAUGdTsdT
antis


 


1062-1081
2289
AUCUUUGGAGCCACAGAUU
2290
AucuuuGGAGccAcAGAuudTsdT
sense


 


1062-1081
2291
AAUCUGUGGCUCCAAAGAU
2292
AAUCUGUGGCUCcAAAGAUdTsdT
antis


 


1086-1105
2293
UCGUCCAUCGAUGUGUGGU
2294
ucGuccAucGAuGuGuGGudTsdT
sense


 


1086-1105
2295
ACCACACAUCGAUGGACGA
2296
ACcAcAcAUCGAUGGACGAdTsdT
antis


 


1099-1118
2297
UGUGGUCGGCUGGCUGUGU
2298
uGuGGucGGcuGGcuGuGudTsdT
sense


 


1099-1118
2299
ACACAGCCAGCCGACCACA
2300
AcAcAGCcAGCCGACcAcAdTsdT
antis


 


1100-1119
2301
GUGGUCGGCUGGCUGUGUA
2302
GuGGucGGcuGGcuGuGuAdTsdT
sense


 


1100-1119
2303
UACACAGCCAGCCGACCAC
2304
uAcAcAGCcAGCCGACcACdTsdT
antis


 


1101-1120
2305
UGGUCGGCUGGCUGUGUAC
2306
uGGucGGcuGGcuGuGuAcdTsdT
sense


 


1101-1120
2307
GUACACAGCCAGCCGACCA
2308
GuAcAcAGCcAGCCGACcAdTsdT
antis


 


1112-1131
2309
CUGUGUACUUGCUGAGCUA
2310
cuGuGuAcuuGcuGAGcuAdTsdT
sense


 


1112-1131
2311
UAGCUCAGCAAGUACACAG
2312
uAGCUcAGcAAGuAcAcAGdTsdT
antis


 


1114-1133
2313
GUGUACUUGCUGAGCUACU
2314
GuGuAcuuGcuGAGcuAcudTsdT
sense


 


1114-1133
2315
AGUAGCUCAGCAAGUACAC
2316
AGuAGCUcAGcAAGuAcACdTsdT
antis


 


1115-1134
2317
UGUACUUGCUGAGCUACUU
2318
uGuAcuuGcuGAGcuAcuudTsdT
sense


 


1115-1134
2319
AAGUAGCUCAGCAAGUACA
2320
AAGuAGCUcAGcAAGuAcAdTsdT
antis


 


1119-1138
2321
CUUGCUGAGCUACUUCUCG
2322
cuuGcuGAGcuAcuucucGdTsdT
sense


 


1119-1138
2323
CGAGAAGUAGCUCAGCAAG
2324
CGAGAAGuAGCUcAGcAAGdTsdT
antis


 


1126-1145
2325
AGCUACUUCUCGGCCAGCC
2326
AGcuAcuucucGGccAGccdTsdT
sense


 


1126-1145
2327
GGCUGGCCGAGAAGUAGCU
2328
GGCUGGCCGAGAAGuAGCUdTsdT
antis


 


1139-1158
2329
CCAGCCCAUCUUCCCUGGG
2330
ccAGcccAucuucccuGGGdTsdT
sense


 


1139-1158
2331
CCCAGGGAAGAUGGGCUGG
2332
CCcAGGGAAGAUGGGCUGGdTsdT
antis


 


1146-1165
2333
AUCUUCCCUGGGGACAGUG
2334
AucuucccuGGGGAcAGuGdTsdT
sense


 


1146-1165
2335
CACUGUCCCCAGGGAAGAU
2336
cACUGUCCCcAGGGAAGAUdTsdT
antis


 


1224-1243
2337
CGAGAGAUGAACCCUAACU
2338
cGAGAGAuGAAcccuAAcudTsdT
sense


 


1224-1243
2339
AGUUAGGGUUCAUCUCUCG
2340
AGUuAGGGUUcAUCUCUCGdTsdT
antis


 


1263-1282
2341
CAGAUCAAAGCUCACCCUU
2342
cAGAucAAAGcucAcccuudTsdT
sense


 


1263-1282
2343
AAGGGUGAGCUUUGAUCUG
2344
AAGGGUGAGCUUUGAUCUGdTsdT
antis


 


1264-1283
2345
AGAUCAAAGCUCACCCUUG
2346
AGAucAAAGcucAcccuuGdTsdT
sense


 


1264-1283
2347
CAAGGGUGAGCUUUGAUCU
2348
cAAGGGUGAGCUUUGAUCUdTsdT
antis


 


1267-1286
2349
UCAAAGCUCACCCUUGGAC
2350
ucAAAGcucAcccuuGGAcdTsdT
sense


 


1267-1286
2351
GUCCAAGGGUGAGCUUUGA
2352
GUCcAAGGGUGAGCUUUGAdTsdT
antis


 


1285-1304
2353
CAAAGGUGUUCAAAUCUUC
2354
cAAAGGuGuucAAAucuucdTsdT
sense


 


1285-1304
2355
GAAGAUUUGAACACCUUUG
2356
GAAGAUUUGAAcACCUUUGdTsdT
antis


 


1286-1305
2357
AAAGGUGUUCAAAUCUUCA
2358
AAAGGuGuucAAAucuucAdTsdT
sense


 


1286-1305
2359
UGAAGAUUUGAACACCUUU
2360
UGAAGAUUUGAAcACCUUUdTsdT
antis


 


1295-1314
2361
CAAAUCUUCAAAGACACCA
2362
cAAAucuucAAAGAcAccAdTsdT
sense


 


1295-1314
2363
UGGUGUCUUUGAAGAUUUG
2364
UGGUGUCUUUGAAGAUUUGdTsdT
antis


 


1304-1323
2365
AAAGACACCACCUGAGGCC
2366
AAAGAcAccAccuGAGGccdTsdT
sense


 


1304-1323
2367
GGCCUCAGGUGGUGUCUUU
2368
GGCCUcAGGUGGUGUCUUUdTsdT
antis


 


1306-1325
2369
AGACACCACCUGAGGCCAU
2370
AGAcAccAccuGAGGccAudTsdT
sense


 


1306-1325
2371
AUGGCCUCAGGUGGUGUCU
2372
AUGGCCUcAGGUGGUGUCUdTsdT
antis


 


1307-1326
2373
GACACCACCUGAGGCCAUU
2374
GAcAccAccuGAGGccAuudTsdT
sense


 


1307-1326
2375
AAUGGCCUCAGGUGGUGUC
2376
AAUGGCCUcAGGUGGUGUCdTsdT
antis


 


1310-1329
2377
ACCACCUGAGGCCAUUGCA
2378
AccAccuGAGGccAuuGcAdTsdT
sense


 


1310-1329
2379
UGCAAUGGCCUCAGGUGGU
2380
UGcAAUGGCCUcAGGUGGUdTsdT
antis


 


1313-1332
2381
ACCUGAGGCCAUUGCACUC
2382
AccuGAGGccAuuGcAcucdTsdT
sense


 


1313-1332
2383
GAGUGCAAUGGCCUCAGGU
2384
GAGUGcAAUGGCCUcAGGUdTsdT
antis


 


1315-1334
2385
CUGAGGCCAUUGCACUCUG
2386
cuGAGGccAuuGcAcucuGdTsdT
sense


 


1315-1334
2387
CAGAGUGCAAUGGCCUCAG
2388
cAGAGUGcAAUGGCCUcAGdTsdT
antis


 


1322-1341
2389
CAUUGCACUCUGCUCUAGC
2390
cAuuGcAcucuGcucuAGcdTsdT
sense


 


1322-1341
2391
GCUAGAGCAGAGUGCAAUG
2392
GCuAGAGcAGAGUGcAAUGdTsdT
antis


 


1330-1349
2393
UCUGCUCUAGCCUACUGGA
2394
ucuGcucuAGccuAcuGGAdTsdT
sense


 


1330-1349
2395
UCCAGUAGGCUAGAGCAGA
2396
UCcAGuAGGCuAGAGcAGAdTsdT
antis


 


1344-1363
2397
CUGGAGUACACGCCAUCCU
2398
cuGGAGuAcAcGccAuccudTsdT
sense


 


1344-1363
2399
AGGAUGGCGUGUACUCCAG
2400
AGGAUGGCGUGuACUCcAGdTsdT
antis


 


1347-1366
2401
GAGUACACGCCAUCCUCAA
2402
GAGuAcAcGccAuccucAAdTsdT
sense


 


1347-1366
2403
UUGAGGAUGGCGUGUACUC
2404
UUGAGGAUGGCGUGuACUCdTsdT
antis


 


1350-1369
2405
UACACGCCAUCCUCAAGGC
2406
uAcAcGccAuccucAAGGcdTsdT
sense


 


1350-1369
2407
GCCUUGAGGAUGGCGUGUA
2408
GCCUUGAGGAUGGCGUGuAdTsdT
antis


 


1366-1385
2409
GGCUCUCCCCACUCGAGGC
2410
GGcucuccccAcucGAGGcdTsdT
sense


 


1366-1385
2411
GCCUCGAGUGGGGAGAGCC
2412
GCCUCGAGUGGGGAGAGCCdTsdT
antis


 


1367-1386
2413
GCUCUCCCCACUCGAGGCU
2414
GcucuccccAcucGAGGcudTsdT
sense


 


1367-1386
2415
AGCCUCGAGUGGGGAGAGC
2416
AGCCUCGAGUGGGGAGAGCdTsdT
antis


 


1368-1387
2417
CUCUCCCCACUCGAGGCUU
2418
cucuccccAcucGAGGcuudTsdT
sense


 


1368-1387
2419
AAGCCUCGAGUGGGGAGAG
2420
AAGCCUCGAGUGGGGAGAGdTsdT
antis


 


1403-1422
2421
CGAUGAACUGCGGAGACUC
2422
cGAuGAAcuGcGGAGAcucdTsdT
sense


 


1403-1422
2423
GAGUCUCCGCAGUUCAUCG
2424
GAGUCUCCGcAGUUcAUCGdTsdT
antis


 


1412-1431
2425
GCGGAGACUCGGAGCCCAG
2426
GcGGAGAcucGGAGcccAGdTsdT
sense


 


1412-1431
2427
CUGGGCUCCGAGUCUCCGC
2428
CUGGGCUCCGAGUCUCCGCdTsdT
antis


 


1413-1432
2429
CGGAGACUCGGAGCCCAGC
2430
cGGAGAcucGGAGcccAGcdTsdT
sense


 


1413-1432
2431
GCUGGGCUCCGAGUCUCCG
2432
GCUGGGCUCCGAGUCUCCGdTsdT
antis


 


1414-1433
2433
GGAGACUCGGAGCCCAGCU
2434
GGAGAcucGGAGcccAGcudTsdT
sense


 


1414-1433
2435
AGCUGGGCUCCGAGUCUCC
2436
AGCUGGGCUCCGAGUCUCCdTsdT
antis


 


1416-1435
2437
AGACUCGGAGCCCAGCUCC
2438
AGAcucGGAGcccAGcuccdTsdT
sense


 


1416-1435
2439
GGAGCUGGGCUCCGAGUCU
2440
GGAGCUGGGCUCCGAGUCUdTsdT
antis


 


1418-1437
2441
ACUCGGAGCCCAGCUCCCC
2442
AcucGGAGcccAGcuccccdTsdT
sense


 


1418-1437
2443
GGGGAGCUGGGCUCCGAGU
2444
GGGGAGCUGGGCUCCGAGUdTsdT
antis


 


1420-1439
2445
UCGGAGCCCAGCUCCCCAA
2446
ucGGAGcccAGcuccccAAdTsdT
sense


 


1420-1439
2447
UUGGGGAGCUGGGCUCCGA
2448
UUGGGGAGCUGGGCUCCGAdTsdT
antis


 


1438-1457
2449
ACGACCGCCCGCUUCCCCC
2450
AcGAccGcccGcuucccccdTsdT
sense


 


1438-1457
2451
GGGGGAAGCGGGCGGUCGU
2452
GGGGGAAGCGGGCGGUCGUdTsdT
antis


 


1447-1466
2453
CGCUUCCCCCCCUGUUCAA
2454
cGcuucccccccuGuucAAdTsdT
sense


 


1447-1466
2455
UUGAACAGGGGGGGAAGCG
2456
UUGAAcAGGGGGGGAAGCGdTsdT
antis


 


1471-1490
2457
GUCCUGGUGAACUGUCCAU
2458
GuccuGGuGAAcuGuccAudTsdT
sense


 


1471-1490
2459
AUGGACAGUUCACCAGGAC
2460
AUGGAcAGUUcACcAGGACdTsdT
antis


 


1476-1495
2461
GGUGAACUGUCCAUCCAAC
2462
GGuGAAcuGuccAuccAAcdTsdT
sense


 


1476-1495
2463
GUUGGAUGGACAGUUCACC
2464
GUUGGAUGGAcAGUUcACCdTsdT
antis


 


1477-1496
2465
GUGAACUGUCCAUCCAACC
2466
GuGAAcuGuccAuccAAccdTsdT
sense


 


1477-1496
2467
GGUUGGAUGGACAGUUCAC
2468
GGUUGGAUGGAcAGUUcACdTsdT
antis


 


1486-1505
2469
CCAUCCAACCAUCUCUCAA
2470
ccAuccAAccAucucucAAdTsdT
sense


 


1486-1505
2471
UUGAGAGAUGGUUGGAUGG
2472
UUGAGAGAUGGUUGGAUGGdTsdT
antis


 


1487-1506
2473
CAUCCAACCAUCUCUCAAU
2474
cAuccAAccAucucucAAudTsdT
sense


 


1487-1506
2475
AUUGAGAGAUGGUUGGAUG
2476
AUUGAGAGAUGGUUGGAUGdTsdT
antis


 


1491-1510
2477
CAACCAUCUCUCAAUGCCA
2478
cAAccAucucucAAuGccAdTsdT
sense


 


1491-1510
2479
UGGCAUUGAGAGAUGGUUG
2480
UGGcAUUGAGAGAUGGUUGdTsdT
antis


 


1492-1511
2481
AACCAUCUCUCAAUGCCAU
2482
AAccAucucucAAuGccAudTsdT
sense


 


1492-1511
2483
AUGGCAUUGAGAGAUGGUU
2484
AUGGcAUUGAGAGAUGGUUdTsdT
antis


 


1493-1512
2485
ACCAUCUCUCAAUGCCAUU
2486
AccAucucucAAuGccAuudTsdT
sense


 


1493-1512
2487
AAUGGCAUUGAGAGAUGGU
2488
AAUGGcAUUGAGAGAUGGUdTsdT
antis


 


1551-1570
2489
UCUCCCCUCACCACUUCCU
2490
ucuccccucAccAcuuccudTsdT
sense


 


1551-1570
2491
AGGAAGUGGUGAGGGGAGA
2492
AGGAAGUGGUGAGGGGAGAdTsdT
antis


 


1553-1572
2493
UCCCCUCACCACUUCCUAC
2494
uccccucAccAcuuccuAcdTsdT
sense


 


1553-1572
2495
GUAGGAAGUGGUGAGGGGA
2496
GuAGGAAGUGGUGAGGGGAdTsdT
antis


 


1556-1575
2497
CCUCACCACUUCCUACAAC
2498
ccucAccAcuuccuAcAAcdTsdT
sense


 


1556-1575
2499
GUUGUAGGAAGUGGUGAGG
2500
GUUGuAGGAAGUGGUGAGGdTsdT
antis


 


1560-1579
2501
ACCACUUCCUACAACCCAU
2502
AccAcuuccuAcAAcccAudTsdT
sense


 


1560-1579
2503
AUGGGUUGUAGGAAGUGGU
2504
AUGGGUUGuAGGAAGUGGUdTsdT
antis


 


1561-1580
2505
CCACUUCCUACAACCCAUC
2506
ccAcuuccuAcAAcccAucdTsdT
sense


 


1561-1580
2507
GAUGGGUUGUAGGAAGUGG
2508
GAUGGGUUGuAGGAAGUGGdTsdT
antis


 


1562-1581
2509
CACUUCCUACAACCCAUCC
2510
cAcuuccuAcAAcccAuccdTsdT
sense


 


1562-1581
2511
GGAUGGGUUGUAGGAAGUG
2512
GGAUGGGUUGuAGGAAGUGdTsdT
antis


 


1564-1583
2513
CUUCCUACAACCCAUCCUC
2514
cuuccuAcAAcccAuccucdTsdT
sense


 


1564-1583
2515
GAGGAUGGGUUGUAGGAAG
2516
GAGGAUGGGUUGuAGGAAGdTsdT
antis


 


1565-1584
2517
UUCCUACAACCCAUCCUCA
2518
uuccuAcAAcccAuccucAdTsdT
sense


 


1565-1584
2519
UGAGGAUGGGUUGUAGGAA
2520
UGAGGAUGGGUUGuAGGAAdTsdT
antis


 


1568-1587
2521
CUACAACCCAUCCUCACAA
2522
cuAcAAcccAuccucAcAAdTsdT
sense


 


1568-1587
2523
UUGUGAGGAUGGGUUGUAG
2524
UUGUGAGGAUGGGUUGuAGdTsdT
antis


 


1569-1588
2525
UACAACCCAUCCUCACAAG
2526
uAcAAcccAuccucAcAAGdTsdT
sense


 


1569-1588
2527
CUUGUGAGGAUGGGUUGUA
2528
CUUGUGAGGAUGGGUUGuAdTsdT
antis


 


1572-1591
2529
AACCCAUCCUCACAAGCUU
2530
AAcccAuccucAcAAGcuudTsdT
sense


 


1572-1591
2531
AAGCUUGUGAGGAUGGGUU
2532
AAGCUUGUGAGGAUGGGUUdTsdT
antis


 


1573-1592
2533
ACCCAUCCUCACAAGCUUU
2534
AcccAuccucAcAAGcuuudTsdT
sense


 


1573-1592
2535
AAAGCUUGUGAGGAUGGGU
2536
AAAGCUUGUGAGGAUGGGUdTsdT
antis


 


1590-1609
2537
UUAACUGAAGCUCAGACUG
2538
uuAAcuGAAGcucAGAcuGdTsdT
sense


 


1590-1609
2539
CAGUCUGAGCUUCAGUUAA
2540
cAGUCUGAGCUUcAGUuAAdTsdT
antis


 


1591-1610
2541
UAACUGAAGCUCAGACUGG
2542
uAAcuGAAGcucAGAcuGGdTsdT
sense


 


1591-1610
2543
CCAGUCUGAGCUUCAGUUA
2544
CcAGUCUGAGCUUcAGUuAdTsdT
antis


 


1592-1611
2545
AACUGAAGCUCAGACUGGC
2546
AAcuGAAGcucAGAcuGGcdTsdT
sense


 


1592-1611
2547
GCCAGUCUGAGCUUCAGUU
2548
GCcAGUCUGAGCUUcAGUUdTsdT
antis


 


1593-1612
2549
ACUGAAGCUCAGACUGGCC
2550
AcuGAAGcucAGAcuGGccdTsdT
sense


 


1593-1612
2551
GGCCAGUCUGAGCUUCAGU
2552
GGCcAGUCUGAGCUUcAGUdTsdT
antis


 


1595-1614
2553
UGAAGCUCAGACUGGCCAA
2554
uGAAGcucAGAcuGGccAAdTsdT
sense


 


1595-1614
2555
UUGGCCAGUCUGAGCUUCA
2556
UUGGCcAGUCUGAGCUUcAdTsdT
antis


 


1601-1620
2557
UCAGACUGGCCAAGAUUGG
2558
ucAGAcuGGccAAGAuuGGdTsdT
sense


 


1601-1620
2559
CCAAUCUUGGCCAGUCUGA
2560
CcAAUCUUGGCcAGUCUGAdTsdT
antis


 


1606-1625
2561
CUGGCCAAGAUUGGCAGCC
2562
cuGGccAAGAuuGGcAGccdTsdT
sense


 


1606-1625
2563
GGCUGCCAAUCUUGGCCAG
2564
GGCUGCcAAUCUUGGCcAGdTsdT
antis


 


1610-1629
2565
CCAAGAUUGGCAGCCAUCU
2566
ccAAGAuuGGcAGccAucudTsdT
sense


 


1610-1629
2567
AGAUGGCUGCCAAUCUUGG
2568
AGAUGGCUGCcAAUCUUGGdTsdT
antis


 


1614-1633
2569
GAUUGGCAGCCAUCUGAUG
2570
GAuuGGcAGccAucuGAuGdTsdT
sense


 


1614-1633
2571
CAUCAGAUGGCUGCCAAUC
2572
cAUcAGAUGGCUGCcAAUCdTsdT
antis


 


1650-1669
2573
GCUAGCUCUUCCUGAGGGC
2574
GcuAGcucuuccuGAGGGcdTsdT
sense


 


1650-1669
2575
GCCCUCAGGAAGAGCUAGC
2576
GCCCUcAGGAAGAGCuAGCdTsdT
antis


 


1654-1673
2577
GCUCUUCCUGAGGGCCCCA
2578
GcucuuccuGAGGGccccAdTsdT
sense


 


1654-1673
2579
UGGGGCCCUCAGGAAGAGC
2580
UGGGGCCCUcAGGAAGAGCdTsdT
antis


 


1657-1676
2581
CUUCCUGAGGGCCCCACCG
2582
cuuccuGAGGGccccAccGdTsdT
sense


 


1657-1676
2583
CGGUGGGGCCCUCAGGAAG
2584
CGGUGGGGCCCUcAGGAAGdTsdT
antis


 


1799-1818
2585
CAUCUAGGCCUCCCUCAGC
2586
cAucuAGGccucccucAGcdTsdT
sense


 


1799-1818
2587
GCUGAGGGAGGCCUAGAUG
2588
GCUGAGGGAGGCCuAGAUGdTsdT
antis


 


1801-1820
2589
UCUAGGCCUCCCUCAGCAG
2590
ucuAGGccucccucAGcAGdTsdT
sense


 


1801-1820
2591
CUGCUGAGGGAGGCCUAGA
2592
CUGCUGAGGGAGGCCuAGAdTsdT
antis


 


1839-1858
2593
UUUUUAAAGAGGAUUUUAA
2594
uuuuuAAAGAGGAuuuuAAdTsdT
sense


 


1839-1858
2595
UUAAAAUCCUCUUUAAAAA
2596
UuAAAAUCCUCUUuAAAAAdTsdT
antis


 


1840-1859
2597
UUUUAAAGAGGAUUUUAAC
2598
uuuuAAAGAGGAuuuuAAcdTsdT
sense


 


1840-1859
2599
GUUAAAAUCCUCUUUAAAA
2600
GUuAAAAUCCUCUUuAAAAdTsdT
antis


 


1841-1860
2601
UUUAAAGAGGAUUUUAACU
2602
uuuAAAGAGGAuuuuAAcudTsdT
sense


 


1841-1860
2603
AGUUAAAAUCCUCUUUAAA
2604
AGUuAAAAUCCUCUUuAAAdTsdT
antis


 


1842-1861
2605
UUAAAGAGGAUUUUAACUG
2606
uuAAAGAGGAuuuuAAcuGdTsdT
sense


 


1842-1861
2607
CAGUUAAAAUCCUCUUUAA
2608
cAGUuAAAAUCCUCUUuAAdTsdT
antis


 


1843-1862
2609
UAAAGAGGAUUUUAACUGU
2610
uAAAGAGGAuuuuAAcuGudTsdT
sense


 


1843-1862
2611
ACAGUUAAAAUCCUCUUUA
2612
AcAGUuAAAAUCCUCUUuAdTsdT
antis


 


1845-1864
2613
AAGAGGAUUUUAACUGUUU
2614
AAGAGGAuuuuAAcuGuuudTsdT
sense


 


1845-1864
2615
AAACAGUUAAAAUCCUCUU
2616
AAAcAGUuAAAAUCCUCUUdTsdT
antis


 


1849-1868
2617
GGAUUUUAACUGUUUGUAG
2618
GGAuuuuAAcuGuuuGuAGdTsdT
sense


 


1849-1868
2619
CUACAAACAGUUAAAAUCC
2620
CuAcAAAcAGUuAAAAUCCdTsdT
antis


 


1858-1877
2621
CUGUUUGUAGGGGAGGGGA
2622
cuGuuuGuAGGGGAGGGGAdTsdT
sense


 


1858-1877
2623
UCCCCUCCCCUACAAACAG
2624
UCCCCUCCCCuAcAAAcAGdTsdT
antis


 


1859-1878
2625
UGUUUGUAGGGGAGGGGAG
2626
uGuuuGuAGGGGAGGGGAGdTsdT
sense


 


1859-1878
2627
CUCCCCUCCCCUACAAACA
2628
CUCCCCUCCCCuAcAAAcAdTsdT
antis


 


1862-1881
2629
UUGUAGGGGAGGGGAGAAA
2630
uuGuAGGGGAGGGGAGAAAdTsdT
sense


 


1862-1881
2631
UUUCUCCCCUCCCCUACAA
2632
UUUCUCCCCUCCCCuAcAAdTsdT
antis


 


1863-1882
2633
UGUAGGGGAGGGGAGAAAA
2634
uGuAGGGGAGGGGAGAAAAdTsdT
sense


 


1863-1882
2635
UUUUCUCCCCUCCCCUACA
2636
UUUUCUCCCCUCCCCuAcAdTsdT
antis


 


1874-1893
2637
GGAGAAAAGGAAGGACGGG
2638
GGAGAAAAGGAAGGAcGGGdTsdT
sense


 


1874-1893
2639
CCCGUCCUUCCUUUUCUCC
2640
CCCGUCCUUCCUUUUCUCCdTsdT
antis


 


1875-1894
2641
GAGAAAAGGAAGGACGGGG
2642
GAGAAAAGGAAGGAcGGGGdTsdT
sense


 


1875-1894
2643
CCCCGUCCUUCCUUUUCUC
2644
CCCCGUCCUUCCUUUUCUCdTsdT
antis


 


1876-1895
2645
AGAAAAGGAAGGACGGGGU
2646
AGAAAAGGAAGGAcGGGGudTsdT
sense


 


1876-1895
2647
ACCCCGUCCUUCCUUUUCU
2648
ACCCCGUCCUUCCUUUUCUdTsdT
antis


 


1878-1897
2649
AAAAGGAAGGACGGGGUUU
2650
AAAAGGAAGGAcGGGGuuudTsdT
sense


 


1878-1897
2651
AAACCCCGUCCUUCCUUUU
2652
AAACCCCGUCCUUCCUUUUdTsdT
antis


 


1898-1917
2653
GGGGUGUGAGGACCUUCUA
2654
GGGGuGuGAGGAccuucuAdTsdT
sense


 


1898-1917
2655
UAGAAGGUCCUCACACCCC
2656
uAGAAGGUCCUcAcACCCCdTsdT
antis


 


1899-1918
2657
GGGUGUGAGGACCUUCUAC
2658
GGGuGuGAGGAccuucuAcdTsdT
sense


 


1899-1918
2659
GUAGAAGGUCCUCACACCC
2660
GuAGAAGGUCCUcAcACCCdTsdT
antis


 


1900-1919
2661
GGUGUGAGGACCUUCUACC
2662
GGuGuGAGGAccuucuAccdTsdT
sense


 


1900-1919
2663
GGUAGAAGGUCCUCACACC
2664
GGuAGAAGGUCCUcAcACCdTsdT
antis


 


1902-1921
2665
UGUGAGGACCUUCUACCCC
2666
uGuGAGGAccuucuAccccdTsdT
sense


 


1902-1921
2667
GGGGUAGAAGGUCCUCACA
2668
GGGGuAGAAGGUCCUcAcAdTsdT
antis


 


1903-1922
2669
GUGAGGACCUUCUACCCCC
2670
GuGAGGAccuucuAcccccdTsdT
sense


 


1903-1922
2671
GGGGGUAGAAGGUCCUCAC
2672
GGGGGuAGAAGGUCCUcACdTsdT
antis


 


1959-1978
2673
CUCCCCCCCUCUCCCAGGU
2674
cucccccccucucccAGGudTsdT
sense


 


1959-1978
2675
ACCUGGGAGAGGGGGGGAG
2676
ACCUGGGAGAGGGGGGGAGdTsdT
antis


 


1964-1983
2677
CCCCUCUCCCAGGUCCCUU
2678
ccccucucccAGGucccuudTsdT
sense


 


1964-1983
2679
AAGGGACCUGGGAGAGGGG
2680
AAGGGACCUGGGAGAGGGGdTsdT
antis


 


1970-1989
2681
UCCCAGGUCCCUUGUAAAU
2682
ucccAGGucccuuGuAAAudTsdT
sense


 


1970-1989
2683
AUUUACAAGGGACCUGGGA
2684
AUUuAcAAGGGACCUGGGAdTsdT
antis


 


1974-1993
2685
AGGUCCCUUGUAAAUAGAA
2686
AGGucccuuGuAAAuAGAAdTsdT
sense


 


1974-1993
2687
UUCUAUUUACAAGGGACCU
2688
UUCuAUUuAcAAGGGACCUdTsdT
antis


 


1983-2002
2689
GUAAAUAGAACCAGCCCAG
2690
GuAAAuAGAAccAGcccAGdTsdT
sense


 


1983-2002
2691
CUGGGCUGGUUCUAUUUAC
2692
CUGGGCUGGUUCuAUUuACdTsdT
antis


 


1984-2003
2693
UAAAUAGAACCAGCCCAGC
2694
uAAAuAGAAccAGcccAGcdTsdT
sense


 


1984-2003
2695
GCUGGGCUGGUUCUAUUUA
2696
GCUGGGCUGGUUCuAUUuAdTsdT
antis


 


1994-2013
2697
CAGCCCAGCCCAUCUCUCG
2698
cAGcccAGcccAucucucGdTsdT
sense


 


1994-2013
2699
CGAGAGAUGGGCUGGGCUG
2700
CGAGAGAUGGGCUGGGCUGdTsdT
antis


 


1995-2014
2701
AGCCCAGCCCAUCUCUCGU
2702
AGcccAGcccAucucucGudTsdT
sense


 


1995-2014
2703
ACGAGAGAUGGGCUGGGCU
2704
ACGAGAGAUGGGCUGGGCUdTsdT
antis


 


1996-2015
2705
GCCCAGCCCAUCUCUCGUC
2706
GcccAGcccAucucucGucdTsdT
sense


 


1996-2015
2707
GACGAGAGAUGGGCUGGGC
2708
GACGAGAGAUGGGCUGGGCdTsdT
antis


 


1998-2017
2709
CCAGCCCAUCUCUCGUCUU
2710
ccAGcccAucucucGucuudTsdT
sense


 


1998-2017
2711
AAGACGAGAGAUGGGCUGG
2712
AAGACGAGAGAUGGGCUGGdTsdT
antis


 


2016-2035
2713
UCCCUUCCCUGGCCCCCUG
2714
ucccuucccuGGcccccuGdTsdT
sense


 


2016-2035
2715
CAGGGGGCCAGGGAAGGGA
2716
cAGGGGGCcAGGGAAGGGAdTsdT
antis


 


2022-2041
2717
CCCUGGCCCCCUGGGUGUA
2718
cccuGGcccccuGGGuGuAdTsdT
sense


 


2022-2041
2719
UACACCCAGGGGGCCAGGG
2720
uAcACCcAGGGGGCcAGGGdTsdT
antis


 


2025-2044
2721
UGGCCCCCUGGGUGUAAAU
2722
uGGcccccuGGGuGuAAAudTsdT
sense


 


2025-2044
2723
AUUUACACCCAGGGGGCCA
2724
AUUuAcACCcAGGGGGCcAdTsdT
antis


 


2026-2045
2725
GGCCCCCUGGGUGUAAAUA
2726
GGcccccuGGGuGuAAAuAdTsdT
sense


 


2026-2045
2727
UAUUUACACCCAGGGGGCC
2728
uAUUuAcACCcAGGGGGCCdTsdT
antis


 


2035-2054
2729
GGUGUAAAUAGAUUGUUAU
2730
GGuGuAAAuAGAuuGuuAudTsdT
sense


 


2035-2054
2731
AUAACAAUCUAUUUACACC
2732
AuAAcAAUCuAUUuAcACCdTsdT
antis


 


2041-2060
2733
AAUAGAUUGUUAUAAUUUU
2734
AAuAGAuuGuuAuAAuuuudTsdT
sense


 


2041-2060
2735
AAAAUUAUAACAAUCUAUU
2736
AAAAUuAuAAcAAUCuAUUdTsdT
antis


 


2047-2066
2737
UUGUUAUAAUUUUUUCUUA
2738
uuGuuAuAAuuuuuucuuAdTsdT
sense


 


2047-2066
2739
UAAGAAAAAAUUAUAACAA
2740
uAAGAAAAAAUuAuAAcAAdTsdT
antis


 


2057-2076
2741
UUUUUCUUAAAGAAAACGU
2742
uuuuucuuAAAGAAAAcGudTsdT
sense


 


2057-2076
2743
ACGUUUUCUUUAAGAAAAA
2744
ACGUUUUCUUuAAGAAAAAdTsdT
antis


 


2058-2077
2745
UUUUCUUAAAGAAAACGUC
2746
uuuucuuAAAGAAAAcGucdTsdT
sense


 


2058-2077
2747
GACGUUUUCUUUAAGAAAA
2748
GACGUUUUCUUuAAGAAAAdTsdT
antis


 


2060-2079
2749
UUCUUAAAGAAAACGUCAA
2750
uucuuAAAGAAAAcGucAAdTsdT
sense


 


2060-2079
2751
UUGACGUUUUCUUUAAGAA
2752
UUGACGUUUUCUUuAAGAAdTsdT
antis


 


2066-2085
2753
AAGAAAACGUCAAUUCACA
2754
AAGAAAAcGucAAuucAcAdTsdT
sense


 


2066-2085
2755
UGUGAAUUGACGUUUUCUU
2756
UGUGAAUUGACGUUUUCUUdTsdT
antis


 


2075-2094
2757
UCAAUUCACACCAUUCAAC
2758
ucAAuucAcAccAuucAAcdTsdT
sense


 


2075-2094
2759
GUUGAAUGGUGUGAAUUGA
2760
GUUGAAUGGUGUGAAUUGAdTsdT
antis


 


2077-2096
2761
AAUUCACACCAUUCAACUU
2762
AAuucAcAccAuucAAcuudTsdT
sense


 


2077-2096
2763
AAGUUGAAUGGUGUGAAUU
2764
AAGUUGAAUGGUGUGAAUUdTsdT
antis


 


2079-2098
2765
UUCACACCAUUCAACUUGC
2766
uucAcAccAuucAAcuuGcdTsdT
sense


 


2079-2098
2767
GCAAGUUGAAUGGUGUGAA
2768
GcAAGUUGAAUGGUGUGAAdTsdT
antis


 


2081-2100
2769
CACACCAUUCAACUUGCCC
2770
cAcAccAuucAAcuuGcccdTsdT
sense


 


2081-2100
2771
GGGCAAGUUGAAUGGUGUG
2772
GGGcAAGUUGAAUGGUGUGdTsdT
antis


 


2091-2110
2773
AACUUGCCCCCCCCAGCUG
2774
AAcuuGccccccccAGcuGdTsdT
sense


 


2091-2110
2775
CAGCUGGGGGGGGCAAGUU
2776
cAGCUGGGGGGGGcAAGUUdTsdT
antis


 


2092-2111
2777
ACUUGCCCCCCCCAGCUGU
2778
AcuuGccccccccAGcuGudTsdT
sense


 


2092-2111
2779
ACAGCUGGGGGGGGCAAGU
2780
AcAGCUGGGGGGGGcAAGUdTsdT
antis


 


2096-2115
2781
GCCCCCCCCAGCUGUACCC
2782
GccccccccAGcuGuAcccdTsdT
sense


 


2096-2115
2783
GGGUACAGCUGGGGGGGGC
2784
GGGuAcAGCUGGGGGGGGCdTsdT
antis


 


2097-2116
2785
CCCCCCCCAGCUGUACCCC
2786
ccccccccAGcuGuAccccdTsdT
sense


 


2097-2116
2787
GGGGUACAGCUGGGGGGGG
2788
GGGGuAcAGCUGGGGGGGGdTsdT
antis


 


2098-2117
2789
CCCCCCCAGCUGUACCCCU
2790
cccccccAGcuGuAccccudTsdT
sense


 


2098-2117
2791
AGGGGUACAGCUGGGGGGG
2792
AGGGGuAcAGCUGGGGGGGdTsdT
antis


 


2099-2118
2793
CCCCCCAGCUGUACCCCUU
2794
ccccccAGcuGuAccccuudTsdT
sense


 


2099-2118
2795
AAGGGGUACAGCUGGGGGG
2796
AAGGGGuAcAGCUGGGGGGdTsdT
antis


 


2100-2119
2797
CCCCCAGCUGUACCCCUUC
2798
cccccAGcuGuAccccuucdTsdT
sense


 


2100-2119
2799
GAAGGGGUACAGCUGGGGG
2800
GAAGGGGuAcAGCUGGGGGdTsdT
antis


 


2107-2126
2801
CUGUACCCCUUCUUGUCCU
2802
cuGuAccccuucuuGuccudTsdT
sense


 


2107-2126
2803
AGGACAAGAAGGGGUACAG
2804
AGGAcAAGAAGGGGuAcAGdTsdT
antis


 


2108-2127
2805
UGUACCCCUUCUUGUCCUC
2806
uGuAccccuucuuGuccucdTsdT
sense


 


2108-2127
2807
GAGGACAAGAAGGGGUACA
2808
GAGGAcAAGAAGGGGuAcAdTsdT
antis


 


2123-2142
2809
CCUCUGCUCCCAAGGCUUC
2810
ccucuGcucccAAGGcuucdTsdT
sense


 


2123-2142
2811
GAAGCCUUGGGAGCAGAGG
2812
GAAGCCUUGGGAGcAGAGGdTsdT
antis


 


2124-2143
2813
CUCUGCUCCCAAGGCUUCC
2814
cucuGcucccAAGGcuuccdTsdT
sense


 


2124-2143
2815
GGAAGCCUUGGGAGCAGAG
2816
GGAAGCCUUGGGAGcAGAGdTsdT
antis


 


2151-2170
2817
CCCAUCCUGGAAGGAGGGG
2818
cccAuccuGGAAGGAGGGGdTsdT
sense


 


2151-2170
2819
CCCCUCCUUCCAGGAUGGG
2820
CCCCUCCUUCcAGGAUGGGdTsdT
antis


 


2157-2176
2821
CUGGAAGGAGGGGAGUAGA
2822
cuGGAAGGAGGGGAGuAGAdTsdT
sense


 


2157-2176
2823
UCUACUCCCCUCCUUCCAG
2824
UCuACUCCCCUCCUUCcAGdTsdT
antis


 


2158-2177
2825
UGGAAGGAGGGGAGUAGAG
2826
uGGAAGGAGGGGAGuAGAGdTsdT
sense


 


2158-2177
2827
CUCUACUCCCCUCCUUCCA
2828
CUCuACUCCCCUCCUUCcAdTsdT
antis


 


2159-2178
2829
GGAAGGAGGGGAGUAGAGA
2830
GGAAGGAGGGGAGuAGAGAdTsdT
sense


 


2159-2178
2831
UCUCUACUCCCCUCCUUCC
2832
UCUCuACUCCCCUCCUUCCdTsdT
antis


 


2160-2179
2833
GAAGGAGGGGAGUAGAGAG
2834
GAAGGAGGGGAGuAGAGAGdTsdT
sense


 


2160-2179
2835
CUCUCUACUCCCCUCCUUC
2836
CUCUCuACUCCCCUCCUUCdTsdT
antis


 


2165-2184
2837
AGGGGAGUAGAGAGAGUCC
2838
AGGGGAGuAGAGAGAGuccdTsdT
sense


 


2165-2184
2839
GGACUCUCUCUACUCCCCU
2840
GGACUCUCUCuACUCCCCUdTsdT
antis


 


2166-2185
2841
GGGGAGUAGAGAGAGUCCC
2842
GGGGAGuAGAGAGAGucccdTsdT
sense


 


2166-2185
2843
GGGACUCUCUCUACUCCCC
2844
GGGACUCUCUCuACUCCCCdTsdT
antis


 


2169-2188
2845
GAGUAGAGAGAGUCCCUGG
2846
GAGuAGAGAGAGucccuGGdTsdT
sense


 


2169-2188
2847
CCAGGGACUCUCUCUACUC
2848
CcAGGGACUCUCUCuACUCdTsdT
antis


 


2173-2192
2849
AGAGAGAGUCCCUGGUGUC
2850
AGAGAGAGucccuGGuGucdTsdT
sense


 


2173-2192
2851
GACACCAGGGACUCUCUCU
2852
GAcACcAGGGACUCUCUCUdTsdT
antis


 


2178-2197
2853
GAGUCCCUGGUGUCUUAGU
2854
GAGucccuGGuGucuuAGudTsdT
sense


 


2178-2197
2855
ACUAAGACACCAGGGACUC
2856
ACuAAGAcACcAGGGACUCdTsdT
antis


 


2179-2198
2857
AGUCCCUGGUGUCUUAGUU
2858
AGucccuGGuGucuuAGuudTsdT
sense


 


2179-2198
2859
AACUAAGACACCAGGGACU
2860
AACuAAGAcACcAGGGACUdTsdT
antis


 


2182-2201
2861
CCCUGGUGUCUUAGUUUCC
2862
cccuGGuGucuuAGuuuccdTsdT
sense


 


2182-2201
2863
GGAAACUAAGACACCAGGG
2864
GGAAACuAAGAcACcAGGGdTsdT
antis


 


2183-2202
2865
CCUGGUGUCUUAGUUUCCA
2866
ccuGGuGucuuAGuuuccAdTsdT
sense


 


2183-2202
2867
UGGAAACUAAGACACCAGG
2868
UGGAAACuAAGAcACcAGGdTsdT
antis


 


2188-2207
2869
UGUCUUAGUUUCCACAGUA
2870
uGucuuAGuuuccAcAGuAdTsdT
sense


 


2188-2207
2871
UACUGUGGAAACUAAGACA
2872
uACUGUGGAAACuAAGAcAdTsdT
antis


 


2198-2217
2873
UCCACAGUAAGGUUUGCCU
2874
uccAcAGuAAGGuuuGccudTsdT
sense


 


2198-2217
2875
AGGCAAACCUUACUGUGGA
2876
AGGcAAACCUuACUGUGGAdTsdT
antis


 


2199-2218
2877
CCACAGUAAGGUUUGCCUG
2878
ccAcAGuAAGGuuuGccuGdTsdT
sense


 


2199-2218
2879
CAGGCAAACCUUACUGUGG
2880
cAGGcAAACCUuACUGUGGdTsdT
antis


 


2200-2219
2881
CACAGUAAGGUUUGCCUGU
2882
cAcAGuAAGGuuuGccuGudTsdT
sense


 


2200-2219
2883
ACAGGCAAACCUUACUGUG
2884
AcAGGcAAACCUuACUGUGdTsdT
antis


 


2201-2220
2885
ACAGUAAGGUUUGCCUGUG
2886
AcAGuAAGGuuuGccuGuGdTsdT
sense


 


2201-2220
2887
CACAGGCAAACCUUACUGU
2888
cAcAGGcAAACCUuACUGUdTsdT
antis


 


2203-2222
2889
AGUAAGGUUUGCCUGUGUA
2890
AGuAAGGuuuGccuGuGuAdTsdT
sense


 


2203-2222
2891
UACACAGGCAAACCUUACU
2892
uAcAcAGGcAAACCUuACUdTsdT
antis


 


2204-2223
2893
GUAAGGUUUGCCUGUGUAC
2894
GuAAGGuuuGccuGuGuAcdTsdT
sense


 


2204-2223
2895
GUACACAGGCAAACCUUAC
2896
GuAcAcAGGcAAACCUuACdTsdT
antis


 


2205-2224
2897
UAAGGUUUGCCUGUGUACA
2898
uAAGGuuuGccuGuGuAcAdTsdT
sense


 


2205-2224
2899
UGUACACAGGCAAACCUUA
2900
UGuAcAcAGGcAAACCUuAdTsdT
antis


 


2210-2229
2901
UUUGCCUGUGUACAGACCU
2902
uuuGccuGuGuAcAGAccudTsdT
sense


 


2210-2229
2903
AGGUCUGUACACAGGCAAA
2904
AGGUCUGuAcAcAGGcAAAdTsdT
antis


 


2211-2230
2905
UUGCCUGUGUACAGACCUC
2906
uuGccuGuGuAcAGAccucdTsdT
sense


 


2211-2230
2907
GAGGUCUGUACACAGGCAA
2908
GAGGUCUGuAcAcAGGcAAdTsdT
antis


 


2214-2233
2909
CCUGUGUACAGACCUCUGU
2910
ccuGuGuAcAGAccucuGudTsdT
sense


 


2214-2233
2911
ACAGAGGUCUGUACACAGG
2912
AcAGAGGUCUGuAcAcAGGdTsdT
antis


 


2215-2234
2913
CUGUGUACAGACCUCUGUU
2914
cuGuGuAcAGAccucuGuudTsdT
sense


 


2215-2234
2915
AACAGAGGUCUGUACACAG
2916
AAcAGAGGUCUGuAcAcAGdTsdT
antis


 


2220-2239
2917
UACAGACCUCUGUUCAAUA
2918
uAcAGAccucuGuucAAuAdTsdT
sense


 


2220-2239
2919
UAUUGAACAGAGGUCUGUA
2920
uAUUGAAcAGAGGUCUGuAdTsdT
antis


 


2224-2243
2921
GACCUCUGUUCAAUAAAUU
2922
GAccucuGuucAAuAAAuudTsdT
sense


 


2224-2243
2923
AAUUUAUUGAACAGAGGUC
2924
AAUUuAUUGAAcAGAGGUCdTsdT
antis


 


2234-2253
2925
CAAUAAAUUAUUGGCAUGA
2926
cAAuAAAuuAuuGGcAuGAdTsdT
sense


 


2234-2253
2927
UCAUGCCAAUAAUUUAUUG
2928
UcAUGCcAAuAAUUuAUUGdTsdT
antis


 


51-70
2929
CGCGGCGGGCGCUGGGCCG
2930
cGcGGcGGGcGcuGGGccGdTsdT
sense


 


51-70
2931
CGGCCCAGCGCCCGCCGCG
2932
CGGCCcAGCGCCCGCCGCGdTsdT
antis


 


173-192
2933
UGGGCCUGCGCUCGGCGCC
2934
uGGGccuGcGcucGGcGccdTsdT
sense


 


173-192
2935
GGCGCCGAGCGCAGGCCCA
2936
GGCGCCGAGCGcAGGCCcAdTsdT
antis


 


205-224
2937
GGCCUUCGGGAGGCGGCCC
2938
GGccuucGGGAGGcGGcccdTsdT
sense


 


205-224
2939
GGGCCGCCUCCCGAAGGCC
2940
GGGCCGCCUCCCGAAGGCCdTsdT
antis


 


221-240
2941
CCCUGGGGGCUCGGGCCGG
2942
cccuGGGGGcucGGGccGGdTsdT
sense


 


221-240
2943
CCGGCCCGAGCCCCCAGGG
2944
CCGGCCCGAGCCCCcAGGGdTsdT
antis


 


224-243
2945
UGGGGGCUCGGGCCGGGCG
2946
uGGGGGcucGGGccGGGcGdTsdT
sense


 


224-243
2947
CGCCCGGCCCGAGCCCCCA
2948
CGCCCGGCCCGAGCCCCcAdTsdT
antis


 


387-406
2949
GGGGGUGGCCCCAGCGGCA
2950
GGGGGuGGccccAGcGGcAdTsdT
sense


 


387-406
2951
UGCCGCUGGGGCCACCCCC
2952
UGCCGCUGGGGCcACCCCCdTsdT
antis


 


392-411
2953
UGGCCCCAGCGGCAGCGGC
2954
uGGccccAGcGGcAGcGGcdTsdT
sense


 


392-411
2955
GCCGCUGCCGCUGGGGCCA
2956
GCCGCUGCCGCUGGGGCcAdTsdT
antis


 


465-484
2957
AAGCUGGGCCGUGACAGCG
2958
AAGcuGGGccGuGAcAGcGdTsdT
sense


 


465-484
2959
CGCUGUCACGGCCCAGCUU
2960
CGCUGUcACGGCCcAGCUUdTsdT
antis


 


505-524
2961
CCACUGUAGGCCAAGGCCC
2962
ccAcuGuAGGccAAGGcccdTsdT
sense


 


505-524
2963
GGGCCUUGGCCUACAGUGG
2964
GGGCCUUGGCCuAcAGUGGdTsdT
antis


 


587-606
2965
AGUAUACCAGGCACGGCUG
2966
AGuAuAccAGGcAcGGcuGdTsdT
sense


 


587-606
2967
CAGCCGUGCCUGGUAUACU
2968
cAGCCGUGCCUGGuAuACUdTsdT
antis


 


601-620
2969
GGCUGGCAGAGACGAGGGA
2970
GGcuGGcAGAGAcGAGGGAdTsdT
sense


 


601-620
2971
UCCCUCGUCUCUGCCAGCC
2972
UCCCUCGUCUCUGCcAGCCdTsdT
antis


 


743-762
2973
GAAGAAGGACGAGCUGUAU
2974
GAAGAAGGAcGAGcuGuAudTsdT
sense


 


743-762
2975
AUACAGCUCGUCCUUCUUC
2976
AuAcAGCUCGUCCUUCUUCdTsdT
antis


 


927-946
2977
AAGCCCCAGAAUUUGCUUG
2978
AAGccccAGAAuuuGcuuGdTsdT
sense


 


927-946
2979
CAAGCAAAUUCUGGGGCUU
2980
cAAGcAAAUUCUGGGGCUUdTsdT
antis


 


932-951
2981
CCAGAAUUUGCUUGUGGAC
2982
ccAGAAuuuGcuuGuGGAcdTsdT
sense


 


932-951
2983
GUCCACAAGCAAAUUCUGG
2984
GUCcAcAAGcAAAUUCUGGdTsdT
antis


 


1054-1073
2985
CAGAACUCAUCUUUGGAGC
2986
cAGAAcucAucuuuGGAGcdTsdT
sense


 


1054-1073
2987
GCUCCAAAGAUGAGUUCUG
2988
GCUCcAAAGAUGAGUUCUGdTsdT
antis


 


1060-1079
2989
UCAUCUUUGGAGCCACAGA
2990
ucAucuuuGGAGccAcAGAdTsdT
sense


 


1060-1079
2991
UCUGUGGCUCCAAAGAUGA
2992
UCUGUGGCUCcAAAGAUGAdTsdT
antis


 


1068-1087
2993
GGAGCCACAGAUUACACCU
2994
GGAGccAcAGAuuAcAccudTsdT
sense


 


1068-1087
2995
AGGUGUAAUCUGUGGCUCC
2996
AGGUGuAAUCUGUGGCUCCdTsdT
antis


 


1094-1113
2997
CGAUGUGUGGUCGGCUGGC
2998
cGAuGuGuGGucGGcuGGcdTsdT
sense


 


1094-1113
2999
GCCAGCCGACCACACAUCG
3000
GCcAGCCGACcAcAcAUCGdTsdT
antis


 


1107-1126
3001
GCUGGCUGUGUACUUGCUG
3002
GcuGGcuGuGuAcuuGcuGdTsdT
sense


 


1107-1126
3003
CAGCAAGUACACAGCCAGC
3004
cAGcAAGuAcAcAGCcAGCdTsdT
antis


 


1108-1127
3005
CUGGCUGUGUACUUGCUGA
3006
cuGGcuGuGuAcuuGcuGAdTsdT
sense


 


1108-1127
3007
UCAGCAAGUACACAGCCAG
3008
UcAGcAAGuAcAcAGCcAGdTsdT
antis


 


1138-1157
3009
GCCAGCCCAUCUUCCCUGG
3010
GccAGcccAucuucccuGGdTsdT
sense


 


1138-1157
3011
CCAGGGAAGAUGGGCUGGC
3012
CcAGGGAAGAUGGGCUGGCdTsdT
antis


 


1149-1168
3013
UUCCCUGGGGACAGUGGGG
3014
uucccuGGGGAcAGuGGGGdTsdT
sense


 


1149-1168
3015
CCCCACUGUCCCCAGGGAA
3016
CCCcACUGUCCCcAGGGAAdTsdT
antis


 


1474-1493
3017
CUGGUGAACUGUCCAUCCA
3018
cuGGuGAAcuGuccAuccAdTsdT
sense


 


1474-1493
3019
UGGAUGGACAGUUCACCAG
3020
UGGAUGGAcAGUUcACcAGdTsdT
antis


 


1480-1499
3021
AACUGUCCAUCCAACCAUC
3022
AAcuGuccAuccAAccAucdTsdT
sense


 


1480-1499
3023
GAUGGUUGGAUGGACAGUU
3024
GAUGGUUGGAUGGAcAGUUdTsdT
antis


 


1555-1574
3025
CCCUCACCACUUCCUACAA
3026
cccucAccAcuuccuAcAAdTsdT
sense


 


1555-1574
3027
UUGUAGGAAGUGGUGAGGG
3028
UUGuAGGAAGUGGUGAGGGdTsdT
antis


 


1848-1867
3029
AGGAUUUUAACUGUUUGUA
3030
AGGAuuuuAAcuGuuuGuAdTsdT
sense


 


1848-1867
3031
UACAAACAGUUAAAAUCCU
3032
uAcAAAcAGUuAAAAUCCUdTsdT
antis


 


2031-2050
3033
CCUGGGUGUAAAUAGAUUG
3034
ccuGGGuGuAAAuAGAuuGdTsdT
sense


 


2031-2050
3035
CAAUCUAUUUACACCCAGG
3036
cAAUCuAUUuAcACCcAGGdTsdT
antis


 


2042-2061
3037
AUAGAUUGUUAUAAUUUUU
3038
AuAGAuuGuuAuAAuuuuudTsdT
sense


 


2042-2061
3039
AAAAAUUAUAACAAUCUAU
3040
AAAAAUuAuAAcAAUCuAUdTsdT
antis


 


2127-2146
3041
UGCUCCCAAGGCUUCCUCC
3042
uGcucccAAGGcuuccuccdTsdT
sense


 


2127-2146
3043
GGAGGAAGCCUUGGGAGCA
3044
GGAGGAAGCCUUGGGAGcAdTsdT
antis


 


2230-2249
3045
UGUUCAAUAAAUUAUUGGC
3046
uGuucAAuAAAuuAuuGGcdTsdT
sense


 


2230-2249
3047
GCCAAUAAUUUAUUGAACA
3048
GCcAAuAAUUuAUUGAAcAdTsdT
antis


 


48-67
3049
CCCCGCGGCGGGCGCUGGG
3050
ccccGcGGcGGGcGcuGGGdTsdT
sense


 


48-67
3051
CCCAGCGCCCGCCGCGGGG
3052
CCcAGCGCCCGCCGCGGGGdTsdT
antis


 


50-69
3053
CCGCGGCGGGCGCUGGGCC
3054
ccGcGGcGGGcGcuGGGccdTsdT
sense


 


50-69
3055
GGCCCAGCGCCCGCCGCGG
3056
GGCCcAGCGCCCGCCGCGGdTsdT
antis


 


56-75
3057
CGGGCGCUGGGCCGGAGCC
3058
cGGGcGcuGGGccGGAGccdTsdT
sense


 


56-75
3059
GGCUCCGGCCCAGCGCCCG
3060
GGCUCCGGCCcAGCGCCCGdTsdT
antis


 


 89-108
3061
GCGGCCUGGAAGAGGCCGG
3062
GcGGccuGGAAGAGGccGGdTsdT
sense


 


 89-108
3063
CCGGCCUCUUCCAGGCCGC
3064
CCGGCCUCUUCcAGGCCGCdTsdT
antis


 


 91-110
3065
GGCCUGGAAGAGGCCGGAG
3066
GGccuGGAAGAGGccGGAGdTsdT
sense


 


 91-110
3067
CUCCGGCCUCUUCCAGGCC
3068
CUCCGGCCUCUUCcAGGCCdTsdT
antis


 


 95-114
3069
UGGAAGAGGCCGGAGCCCA
3070
uGGAAGAGGccGGAGcccAdTsdT
sense


 


 95-114
3071
UGGGCUCCGGCCUCUUCCA
3072
UGGGCUCCGGCCUCUUCcAdTsdT
antis


 


 96-115
3073
GGAAGAGGCCGGAGCCCAG
3074
GGAAGAGGccGGAGcccAGdTsdT
sense


 


 96-115
3075
CUGGGCUCCGGCCUCUUCC
3076
CUGGGCUCCGGCCUCUUCCdTsdT
antis


 


103-122
3077
GCCGGAGCCCAGGGGAGGC
3078
GccGGAGcccAGGGGAGGcdTsdT
sense


 


103-122
3079
GCCUCCCCUGGGCUCCGGC
3080
GCCUCCCCUGGGCUCCGGCdTsdT
antis


 


104-123
3081
CCGGAGCCCAGGGGAGGCG
3082
ccGGAGcccAGGGGAGGcGdTsdT
sense


 


104-123
3083
CGCCUCCCCUGGGCUCCGG
3084
CGCCUCCCCUGGGCUCCGGdTsdT
antis


 


105-124
3085
CGGAGCCCAGGGGAGGCGG
3086
cGGAGcccAGGGGAGGcGGdTsdT
sense


 


105-124
3087
CCGCCUCCCCUGGGCUCCG
3088
CCGCCUCCCCUGGGCUCCGdTsdT
antis


 


134-153
3089
AGCGGCGGGGGCAGCCCAG
3090
AGcGGcGGGGGcAGcccAGdTsdT
sense


 


134-153
3091
CUGGGCUGCCCCCGCCGCU
3092
CUGGGCUGCCCCCGCCGCUdTsdT
antis


 


147-166
3093
GCCCAGGCAGCCCGAGCCC
3094
GcccAGGcAGcccGAGcccdTsdT
sense


 


147-166
3095
GGGCUCGGGCUGCCUGGGC
3096
GGGCUCGGGCUGCCUGGGCdTsdT
antis


 


158-177
3097
CCGAGCCCCGCGGCCUGGG
3098
ccGAGccccGcGGccuGGGdTsdT
sense


 


158-177
3099
CCCAGGCCGCGGGGCUCGG
3100
CCcAGGCCGCGGGGCUCGGdTsdT
antis


 


167-186
3101
GCGGCCUGGGCCUGCGCUC
3102
GcGGccuGGGccuGcGcucdTsdT
sense


 


167-186
3103
GAGCGCAGGCCCAGGCCGC
3104
GAGCGcAGGCCcAGGCCGCdTsdT
antis


 


172-191
3105
CUGGGCCUGCGCUCGGCGC
3106
cuGGGccuGcGcucGGcGcdTsdT
sense


 


172-191
3107
GCGCCGAGCGCAGGCCCAG
3108
GCGCCGAGCGcAGGCCcAGdTsdT
antis


 


204-223
3109
GGGCCUUCGGGAGGCGGCC
3110
GGGccuucGGGAGGcGGccdTsdT
sense


 


204-223
3111
GGCCGCCUCCCGAAGGCCC
3112
GGCCGCCUCCCGAAGGCCCdTsdT
antis


 


209-228
3113
UUCGGGAGGCGGCCCUGGG
3114
uucGGGAGGcGGcccuGGGdTsdT
sense


 


209-228
3115
CCCAGGGCCGCCUCCCGAA
3116
CCcAGGGCCGCCUCCCGAAdTsdT
antis


 


231-250
3117
UCGGGCCGGGCGCGGACCA
3118
ucGGGccGGGcGcGGAccAdTsdT
sense


 


231-250
3119
UGGUCCGCGCCCGGCCCGA
3120
UGGUCCGCGCCCGGCCCGAdTsdT
antis


 


256-275
3121
UCGCGGAGCCAGGAGGCGG
3122
ucGcGGAGccAGGAGGcGGdTsdT
sense


 


256-275
3123
CCGCCUCCUGGCUCCGCGA
3124
CCGCCUCCUGGCUCCGCGAdTsdT
antis


 


294-313
3125
GGCCCCGGGGGCUCGGCCU
3126
GGccccGGGGGcucGGccudTsdT
sense


 


294-313
3127
AGGCCGAGCCCCCGGGGCC
3128
AGGCCGAGCCCCCGGGGCCdTsdT
antis


 


295-314
3129
GCCCCGGGGGCUCGGCCUC
3130
GccccGGGGGcucGGccucdTsdT
sense


 


295-314
3131
GAGGCCGAGCCCCCGGGGC
3132
GAGGCCGAGCCCCCGGGGCdTsdT
antis


 


318-337
3133
CCAGGAGGCACUGGCGGCG
3134
ccAGGAGGcAcuGGcGGcGdTsdT
sense


 


318-337
3135
CGCCGCCAGUGCCUCCUGG
3136
CGCCGCcAGUGCCUCCUGGdTsdT
antis


 


369-388
3137
GUGGGAGCCUCGAGCUCCG
3138
GuGGGAGccucGAGcuccGdTsdT
sense


 


369-388
3139
CGGAGCUCGAGGCUCCCAC
3140
CGGAGCUCGAGGCUCCcACdTsdT
antis


 


386-405
3141
CGGGGGUGGCCCCAGCGGC
3142
cGGGGGuGGccccAGcGGcdTsdT
sense


 


386-405
3143
GCCGCUGGGGCCACCCCCG
3144
GCCGCUGGGGCcACCCCCGdTsdT
antis


 


390-409
3145
GGUGGCCCCAGCGGCAGCG
3146
GGuGGccccAGcGGcAGcGdTsdT
sense


 


390-409
3147
CGCUGCCGCUGGGGCCACC
3148
CGCUGCCGCUGGGGCcACCdTsdT
antis


 


391-410
3149
GUGGCCCCAGCGGCAGCGG
3150
GuGGccccAGcGGcAGcGGdTsdT
sense


 


391-410
3151
CCGCUGCCGCUGGGGCCAC
3152
CCGCUGCCGCUGGGGCcACdTsdT
antis


 


460-479
3153
GAGUGAAGCUGGGCCGUGA
3154
GAGuGAAGcuGGGccGuGAdTsdT
sense


 


460-479
3155
UCACGGCCCAGCUUCACUC
3156
UcACGGCCcAGCUUcACUCdTsdT
antis


 


491-510
3157
GACCACAGUGGUAGCCACU
3158
GAccAcAGuGGuAGccAcudTsdT
sense


 


491-510
3159
AGUGGCUACCACUGUGGUC
3160
AGUGGCuACcACUGUGGUCdTsdT
antis


 


494-513
3161
CACAGUGGUAGCCACUGUA
3162
cAcAGuGGuAGccAcuGuAdTsdT
sense


 


494-513
3163
UACAGUGGCUACCACUGUG
3164
uAcAGUGGCuACcACUGUGdTsdT
antis


 


504-523
3165
GCCACUGUAGGCCAAGGCC
3166
GccAcuGuAGGccAAGGccdTsdT
sense


 


504-523
3167
GGCCUUGGCCUACAGUGGC
3168
GGCCUUGGCCuAcAGUGGCdTsdT
antis


 


593-612
3169
CCAGGCACGGCUGGCAGAG
3170
ccAGGcAcGGcuGGcAGAGdTsdT
sense


 


593-612
3171
CUCUGCCAGCCGUGCCUGG
3172
CUCUGCcAGCCGUGCCUGGdTsdT
antis


 


600-619
3173
CGGCUGGCAGAGACGAGGG
3174
cGGcuGGcAGAGAcGAGGGdTsdT
sense


 


600-619
3175
CCCUCGUCUCUGCCAGCCG
3176
CCCUCGUCUCUGCcAGCCGdTsdT
antis


 


613-632
3177
CGAGGGAACUGGUGGCCAU
3178
cGAGGGAAcuGGuGGccAudTsdT
sense


 


613-632
3179
AUGGCCACCAGUUCCCUCG
3180
AUGGCcACcAGUUCCCUCGdTsdT
antis


 


650-669
3181
CAAAAGGUUCAAGAACCGA
3182
cAAAAGGuucAAGAAccGAdTsdT
sense


 


650-669
3183
UCGGUUCUUGAACCUUUUG
3184
UCGGUUCUUGAACCUUUUGdTsdT
antis


 


841-860
3185
CUAUCAUCUACAUCAAGGU
3186
cuAucAucuAcAucAAGGudTsdT
sense


 


841-860
3187
ACCUUGAUGUAGAUGAUAG
3188
ACCUUGAUGuAGAUGAuAGdTsdT
antis


 


842-861
3189
UAUCAUCUACAUCAAGGUG
3190
uAucAucuAcAucAAGGuGdTsdT
sense


 


842-861
3191
CACCUUGAUGUAGAUGAUA
3192
cACCUUGAUGuAGAUGAuAdTsdT
antis


 


895-914
3193
UCCACUCCCAAGGUGUGUG
3194
uccAcucccAAGGuGuGuGdTsdT
sense


 


895-914
3195
CACACACCUUGGGAGUGGA
3196
cAcAcACCUUGGGAGUGGAdTsdT
antis


 


900-919
3197
UCCCAAGGUGUGUGUCACC
3198
ucccAAGGuGuGuGucAccdTsdT
sense


 


900-919
3199
GGUGACACACACCUUGGGA
3200
GGUGAcAcAcACCUUGGGAdTsdT
antis


 


901-920
3201
CCCAAGGUGUGUGUCACCG
3202
cccAAGGuGuGuGucAccGdTsdT
sense


 


901-920
3203
CGGUGACACACACCUUGGG
3204
CGGUGAcAcAcACCUUGGGdTsdT
antis


 


924-943
3205
AUCAAGCCCCAGAAUUUGC
3206
AucAAGccccAGAAuuuGcdTsdT
sense


 


924-943
3207
GCAAAUUCUGGGGCUUGAU
3208
GcAAAUUCUGGGGCUUGAUdTsdT
antis


 


925-944
3209
UCAAGCCCCAGAAUUUGCU
3210
ucAAGccccAGAAuuuGcudTsdT
sense


 


925-944
3211
AGCAAAUUCUGGGGCUUGA
3212
AGcAAAUUCUGGGGCUUGAdTsdT
antis


 


926-945
3213
CAAGCCCCAGAAUUUGCUU
3214
cAAGccccAGAAuuuGcuudTsdT
sense


 


926-945
3215
AAGCAAAUUCUGGGGCUUG
3216
AAGcAAAUUCUGGGGCUUGdTsdT
antis


 


953-972
3217
UGACACUGCUGUCCUCAAG
3218
uGAcAcuGcuGuccucAAGdTsdT
sense


 


953-972
3219
CUUGAGGACAGCAGUGUCA
3220
CUUGAGGAcAGcAGUGUcAdTsdT
antis


 


1053-1072
3221
CCAGAACUCAUCUUUGGAG
3222
ccAGAAcucAucuuuGGAGdTsdT
sense


 


1053-1072
3223
CUCCAAAGAUGAGUUCUGG
3224
CUCcAAAGAUGAGUUCUGGdTsdT
antis


 


1057-1076
3225
AACUCAUCUUUGGAGCCAC
3226
AAcucAucuuuGGAGccAcdTsdT
sense


 


1057-1076
3227
GUGGCUCCAAAGAUGAGUU
3228
GUGGCUCcAAAGAUGAGUUdTsdT
antis


 


1063-1082
3229
UCUUUGGAGCCACAGAUUA
3230
ucuuuGGAGccAcAGAuuAdTsdT
sense


 


1063-1082
3231
UAAUCUGUGGCUCCAAAGA
3232
uAAUCUGUGGCUCcAAAGAdTsdT
antis


 


1069-1088
3233
GAGCCACAGAUUACACCUC
3234
GAGccAcAGAuuAcAccucdTsdT
sense


 


1069-1088
3235
GAGGUGUAAUCUGUGGCUC
3236
GAGGUGuAAUCUGUGGCUCdTsdT
antis


 


1106-1125
3237
GGCUGGCUGUGUACUUGCU
3238
GGcuGGcuGuGuAcuuGcudTsdT
sense


 


1106-1125
3239
AGCAAGUACACAGCCAGCC
3240
AGcAAGuAcAcAGCcAGCCdTsdT
antis


 


1118-1137
3241
ACUUGCUGAGCUACUUCUC
3242
AcuuGcuGAGcuAcuucucdTsdT
sense


 


1118-1137
3243
GAGAAGUAGCUCAGCAAGU
3244
GAGAAGuAGCUcAGcAAGUdTsdT
antis


 


1135-1154
3245
UCGGCCAGCCCAUCUUCCC
3246
ucGGccAGcccAucuucccdTsdT
sense


 


1135-1154
3247
GGGAAGAUGGGCUGGCCGA
3248
GGGAAGAUGGGCUGGCCGAdTsdT
antis


 


1137-1156
3249
GGCCAGCCCAUCUUCCCUG
3250
GGccAGcccAucuucccuGdTsdT
sense


 


1137-1156
3251
CAGGGAAGAUGGGCUGGCC
3252
cAGGGAAGAUGGGCUGGCCdTsdT
antis


 


1140-1159
3253
CAGCCCAUCUUCCCUGGGG
3254
cAGcccAucuucccuGGGGdTsdT
sense


 


1140-1159
3255
CCCCAGGGAAGAUGGGCUG
3256
CCCcAGGGAAGAUGGGCUGdTsdT
antis


 


1145-1164
3257
CAUCUUCCCUGGGGACAGU
3258
cAucuucccuGGGGAcAGudTsdT
sense


 


1145-1164
3259
ACUGUCCCCAGGGAAGAUG
3260
ACUGUCCCcAGGGAAGAUGdTsdT
antis


 


1150-1169
3261
UCCCUGGGGACAGUGGGGU
3262
ucccuGGGGAcAGuGGGGudTsdT
sense


 


1150-1169
3263
ACCCCACUGUCCCCAGGGA
3264
ACCCcACUGUCCCcAGGGAdTsdT
antis


 


1270-1289
3265
AAGCUCACCCUUGGACAAA
3266
AAGcucAcccuuGGAcAAAdTsdT
sense


 


1270-1289
3267
UUUGUCCAAGGGUGAGCUU
3268
UUUGUCcAAGGGUGAGCUUdTsdT
antis


 


1296-1315
3269
AAAUCUUCAAAGACACCAC
3270
AAAucuucAAAGAcAccAcdTsdT
sense


 


1296-1315
3271
GUGGUGUCUUUGAAGAUUU
3272
GUGGUGUCUUUGAAGAUUUdTsdT
antis


 


1297-1316
3273
AAUCUUCAAAGACACCACC
3274
AAucuucAAAGAcAccAccdTsdT
sense


 


1297-1316
3275
GGUGGUGUCUUUGAAGAUU
3276
GGUGGUGUCUUUGAAGAUUdTsdT
antis


 


1302-1321
3277
UCAAAGACACCACCUGAGG
3278
ucAAAGAcAccAccuGAGGdTsdT
sense


 


1302-1321
3279
CCUCAGGUGGUGUCUUUGA
3280
CCUcAGGUGGUGUCUUUGAdTsdT
antis


 


1309-1328
3281
CACCACCUGAGGCCAUUGC
3282
cAccAccuGAGGccAuuGcdTsdT
sense


 


1309-1328
3283
GCAAUGGCCUCAGGUGGUG
3284
GcAAUGGCCUcAGGUGGUGdTsdT
antis


 


1331-1350
3285
CUGCUCUAGCCUACUGGAG
3286
cuGcucuAGccuAcuGGAGdTsdT
sense


 


1331-1350
3287
CUCCAGUAGGCUAGAGCAG
3288
CUCcAGuAGGCuAGAGcAGdTsdT
antis


 


1422-1441
3289
GGAGCCCAGCUCCCCAACG
3290
GGAGcccAGcuccccAAcGdTsdT
sense


 


1422-1441
3291
CGUUGGGGAGCUGGGCUCC
3292
CGUUGGGGAGCUGGGCUCCdTsdT
antis


 


1441-1460
3293
ACCGCCCGCUUCCCCCCCU
3294
AccGcccGcuucccccccudTsdT
sense


 


1441-1460
3295
AGGGGGGGAAGCGGGCGGU
3296
AGGGGGGGAAGCGGGCGGUdTsdT
antis


 


1475-1494
3297
UGGUGAACUGUCCAUCCAA
3298
uGGuGAAcuGuccAuccAAdTsdT
sense


 


1475-1494
3299
UUGGAUGGACAGUUCACCA
3300
UUGGAUGGAcAGUUcACcAdTsdT
antis


 


1490-1509
3301
CCAACCAUCUCUCAAUGCC
3302
ccAAccAucucucAAuGccdTsdT
sense


 


1490-1509
3303
GGCAUUGAGAGAUGGUUGG
3304
GGcAUUGAGAGAUGGUUGGdTsdT
antis


 


1543-1562
3305
GCCCUGCUUCUCCCCUCAC
3306
GcccuGcuucuccccucAcdTsdT
sense


 


1543-1562
3307
GUGAGGGGAGAAGCAGGGC
3308
GUGAGGGGAGAAGcAGGGCdTsdT
antis


 


1544-1563
3309
CCCUGCUUCUCCCCUCACC
3310
cccuGcuucuccccucAccdTsdT
sense


 


1544-1563
3311
GGUGAGGGGAGAAGCAGGG
3312
GGUGAGGGGAGAAGcAGGGdTsdT
antis


 


1545-1564
3313
CCUGCUUCUCCCCUCACCA
3314
ccuGcuucuccccucAccAdTsdT
sense


 


1545-1564
3315
UGGUGAGGGGAGAAGCAGG
3316
UGGUGAGGGGAGAAGcAGGdTsdT
antis


 


1546-1565
3317
CUGCUUCUCCCCUCACCAC
3318
cuGcuucuccccucAccAcdTsdT
sense


 


1546-1565
3319
GUGGUGAGGGGAGAAGCAG
3320
GUGGUGAGGGGAGAAGcAGdTsdT
antis


 


1550-1569
3321
UUCUCCCCUCACCACUUCC
3322
uucuccccucAccAcuuccdTsdT
sense


 


1550-1569
3323
GGAAGUGGUGAGGGGAGAA
3324
GGAAGUGGUGAGGGGAGAAdTsdT
antis


 


1559-1578
3325
CACCACUUCCUACAACCCA
3326
cAccAcuuccuAcAAcccAdTsdT
sense


 


1559-1578
3327
UGGGUUGUAGGAAGUGGUG
3328
UGGGUUGuAGGAAGUGGUGdTsdT
antis


 


1574-1593
3329
CCCAUCCUCACAAGCUUUA
3330
cccAuccucAcAAGcuuuAdTsdT
sense


 


1574-1593
3331
UAAAGCUUGUGAGGAUGGG
3332
uAAAGCUUGUGAGGAUGGGdTsdT
antis


 


1585-1604
3333
AAGCUUUAACUGAAGCUCA
3334
AAGcuuuAAcuGAAGcucAdTsdT
sense


 


1585-1604
3335
UGAGCUUCAGUUAAAGCUU
3336
UGAGCUUcAGUuAAAGCUUdTsdT
antis


 


1598-1617
3337
AGCUCAGACUGGCCAAGAU
3338
AGcucAGAcuGGccAAGAudTsdT
sense


 


1598-1617
3339
AUCUUGGCCAGUCUGAGCU
3340
AUCUUGGCcAGUCUGAGCUdTsdT
antis


 


1599-1618
3341
GCUCAGACUGGCCAAGAUU
3342
GcucAGAcuGGccAAGAuudTsdT
sense


 


1599-1618
3343
AAUCUUGGCCAGUCUGAGC
3344
AAUCUUGGCcAGUCUGAGCdTsdT
antis


 


1605-1624
3345
ACUGGCCAAGAUUGGCAGC
3346
AcuGGccAAGAuuGGcAGcdTsdT
sense


 


1605-1624
3347
GCUGCCAAUCUUGGCCAGU
3348
GCUGCcAAUCUUGGCcAGUdTsdT
antis


 


1611-1630
3349
CAAGAUUGGCAGCCAUCUG
3350
cAAGAuuGGcAGccAucuGdTsdT
sense


 


1611-1630
3351
CAGAUGGCUGCCAAUCUUG
3352
cAGAUGGCUGCcAAUCUUGdTsdT
antis


 


1612-1631
3353
AAGAUUGGCAGCCAUCUGA
3354
AAGAuuGGcAGccAucuGAdTsdT
sense


 


1612-1631
3355
UCAGAUGGCUGCCAAUCUU
3356
UcAGAUGGCUGCcAAUCUUdTsdT
antis


 


1651-1670
3357
CUAGCUCUUCCUGAGGGCC
3358
cuAGcucuuccuGAGGGccdTsdT
sense


 


1651-1670
3359
GGCCCUCAGGAAGAGCUAG
3360
GGCCCUcAGGAAGAGCuAGdTsdT
antis


 


1655-1674
3361
CUCUUCCUGAGGGCCCCAC
3362
cucuuccuGAGGGccccAcdTsdT
sense


 


1655-1674
3363
GUGGGGCCCUCAGGAAGAG
3364
GUGGGGCCCUcAGGAAGAGdTsdT
antis


 


1656-1675
3365
UCUUCCUGAGGGCCCCACC
3366
ucuuccuGAGGGccccAccdTsdT
sense


 


1656-1675
3367
GGUGGGGCCCUCAGGAAGA
3368
GGUGGGGCCCUcAGGAAGAdTsdT
antis


 


1803-1822
3369
UAGGCCUCCCUCAGCAGCC
3370
uAGGccucccucAGcAGccdTsdT
sense


 


1803-1822
3371
GGCUGCUGAGGGAGGCCUA
3372
GGCUGCUGAGGGAGGCCuAdTsdT
antis


 


1804-1823
3373
AGGCCUCCCUCAGCAGCCU
3374
AGGccucccucAGcAGccudTsdT
sense


 


1804-1823
3375
AGGCUGCUGAGGGAGGCCU
3376
AGGCUGCUGAGGGAGGCCUdTsdT
antis


 


1805-1824
3377
GGCCUCCCUCAGCAGCCUA
3378
GGccucccucAGcAGccuAdTsdT
sense


 


1805-1824
3379
UAGGCUGCUGAGGGAGGCC
3380
uAGGCUGCUGAGGGAGGCCdTsdT
antis


 


1806-1825
3381
GCCUCCCUCAGCAGCCUAA
3382
GccucccucAGcAGccuAAdTsdT
sense


 


1806-1825
3383
UUAGGCUGCUGAGGGAGGC
3384
UuAGGCUGCUGAGGGAGGCdTsdT
antis


 


1810-1829
3385
CCCUCAGCAGCCUAACCUC
3386
cccucAGcAGccuAAccucdTsdT
sense


 


1810-1829
3387
GAGGUUAGGCUGCUGAGGG
3388
GAGGUuAGGCUGCUGAGGGdTsdT
antis


 


1846-1865
3389
AGAGGAUUUUAACUGUUUG
3390
AGAGGAuuuuAAcuGuuuGdTsdT
sense


 


1846-1865
3391
CAAACAGUUAAAAUCCUCU
3392
cAAAcAGUuAAAAUCCUCUdTsdT
antis


 


1871-1890
3393
AGGGGAGAAAAGGAAGGAC
3394
AGGGGAGAAAAGGAAGGAcdTsdT
sense


 


1871-1890
3395
GUCCUUCCUUUUCUCCCCU
3396
GUCCUUCCUUUUCUCCCCUdTsdT
antis


 


1873-1892
3397
GGGAGAAAAGGAAGGACGG
3398
GGGAGAAAAGGAAGGAcGGdTsdT
sense


 


1873-1892
3399
CCGUCCUUCCUUUUCUCCC
3400
CCGUCCUUCCUUUUCUCCCdTsdT
antis


 


1877-1896
3401
GAAAAGGAAGGACGGGGUU
3402
GAAAAGGAAGGAcGGGGuudTsdT
sense


 


1877-1896
3403
AACCCCGUCCUUCCUUUUC
3404
AACCCCGUCCUUCCUUUUCdTsdT
antis


 


1933-1952
3405
CCCUCCCCCAGGCUACCAC
3406
cccucccccAGGcuAccAcdTsdT
sense


 


1933-1952
3407
GUGGUAGCCUGGGGGAGGG
3408
GUGGuAGCCUGGGGGAGGGdTsdT
antis


 


1934-1953
3409
CCUCCCCCAGGCUACCACU
3410
ccucccccAGGcuAccAcudTsdT
sense


 


1934-1953
3411
AGUGGUAGCCUGGGGGAGG
3412
AGUGGuAGCCUGGGGGAGGdTsdT
antis


 


1940-1959
3413
CCAGGCUACCACUCCUUCC
3414
ccAGGcuAccAcuccuuccdTsdT
sense


 


1940-1959
3415
GGAAGGAGUGGUAGCCUGG
3416
GGAAGGAGUGGuAGCCUGGdTsdT
antis


 


1941-1960
3417
CAGGCUACCACUCCUUCCC
3418
cAGGcuAccAcuccuucccdTsdT
sense


 


1941-1960
3419
GGGAAGGAGUGGUAGCCUG
3420
GGGAAGGAGUGGuAGCCUGdTsdT
antis


 


1945-1964
3421
CUACCACUCCUUCCCUCCC
3422
cuAccAcuccuucccucccdTsdT
sense


 


1945-1964
3423
GGGAGGGAAGGAGUGGUAG
3424
GGGAGGGAAGGAGUGGuAGdTsdT
antis


 


1946-1965
3425
UACCACUCCUUCCCUCCCC
3426
uAccAcuccuucccuccccdTsdT
sense


 


1946-1965
3427
GGGGAGGGAAGGAGUGGUA
3428
GGGGAGGGAAGGAGUGGuAdTsdT
antis


 


1953-1972
3429
CCUUCCCUCCCCCCCUCUC
3430
ccuucccucccccccucucdTsdT
sense


 


1953-1972
3431
GAGAGGGGGGGAGGGAAGG
3432
GAGAGGGGGGGAGGGAAGGdTsdT
antis


 


2023-2042
3433
CCUGGCCCCCUGGGUGUAA
3434
ccuGGcccccuGGGuGuAAdTsdT
sense


 


2023-2042
3435
UUACACCCAGGGGGCCAGG
3436
UuAcACCcAGGGGGCcAGGdTsdT
antis


 


2024-2043
3437
CUGGCCCCCUGGGUGUAAA
3438
cuGGcccccuGGGuGuAAAdTsdT
sense


 


2024-2043
3439
UUUACACCCAGGGGGCCAG
3440
UUuAcACCcAGGGGGCcAGdTsdT
antis


 


2040-2059
3441
AAAUAGAUUGUUAUAAUUU
3442
AAAuAGAuuGuuAuAAuuudTsdT
sense


 


2040-2059
3443
AAAUUAUAACAAUCUAUUU
3444
AAAUuAuAAcAAUCuAUUUdTsdT
antis


 


2043-2062
3445
UAGAUUGUUAUAAUUUUUU
3446
uAGAuuGuuAuAAuuuuuudTsdT
sense


 


2043-2062
3447
AAAAAAUUAUAACAAUCUA
3448
AAAAAAUuAuAAcAAUCuAdTsdT
antis


 


2044-2063
3449
AGAUUGUUAUAAUUUUUUC
3450
AGAuuGuuAuAAuuuuuucdTsdT
sense


 


2044-2063
3451
GAAAAAAUUAUAACAAUCU
3452
GAAAAAAUuAuAAcAAUCUdTsdT
antis


 


2045-2064
3453
GAUUGUUAUAAUUUUUUCU
3454
GAuuGuuAuAAuuuuuucudTsdT
sense


 


2045-2064
3455
AGAAAAAAUUAUAACAAUC
3456
AGAAAAAAUuAuAAcAAUCdTsdT
antis


 


2046-2065
3457
AUUGUUAUAAUUUUUUCUU
3458
AuuGuuAuAAuuuuuucuudTsdT
sense


 


2046-2065
3459
AAGAAAAAAUUAUAACAAU
3460
AAGAAAAAAUuAuAAcAAUdTsdT
antis


 


2049-2068
3461
GUUAUAAUUUUUUCUUAAA
3462
GuuAuAAuuuuuucuuAAAdTsdT
sense


 


2049-2068
3463
UUUAAGAAAAAAUUAUAAC
3464
UUuAAGAAAAAAUuAuAACdTsdT
antis


 


2117-2136
3465
UCUUGUCCUCUGCUCCCAA
3466
ucuuGuccucuGcucccAAdTsdT
sense


 


2117-2136
3467
UUGGGAGCAGAGGACAAGA
3468
UUGGGAGcAGAGGAcAAGAdTsdT
antis


 


2118-2137
3469
CUUGUCCUCUGCUCCCAAG
3470
cuuGuccucuGcucccAAGdTsdT
sense


 


2118-2137
3471
CUUGGGAGCAGAGGACAAG
3472
CUUGGGAGcAGAGGAcAAGdTsdT
antis


 


2129-2148
3473
CUCCCAAGGCUUCCUCCCU
3474
cucccAAGGcuuccucccudTsdT
sense


 


2129-2148
3475
AGGGAGGAAGCCUUGGGAG
3476
AGGGAGGAAGCCUUGGGAGdTsdT
antis


 


2130-2149
3477
UCCCAAGGCUUCCUCCCUC
3478
ucccAAGGcuuccucccucdTsdT
sense


 


2130-2149
3479
GAGGGAGGAAGCCUUGGGA
3480
GAGGGAGGAAGCCUUGGGAdTsdT
antis


 


2133-2152
3481
CAAGGCUUCCUCCCUCUCC
3482
cAAGGcuuccucccucuccdTsdT
sense


 


2133-2152
3483
GGAGAGGGAGGAAGCCUUG
3484
GGAGAGGGAGGAAGCCUUGdTsdT
antis


 


2134-2153
3485
AAGGCUUCCUCCCUCUCCC
3486
AAGGcuuccucccucucccdTsdT
sense


 


2134-2153
3487
GGGAGAGGGAGGAAGCCUU
3488
GGGAGAGGGAGGAAGCCUUdTsdT
antis


 


2146-2165
3489
CUCUCCCCAUCCUGGAAGG
3490
cucuccccAuccuGGAAGGdTsdT
sense


 


2146-2165
3491
CCUUCCAGGAUGGGGAGAG
3492
CCUUCcAGGAUGGGGAGAGdTsdT
antis


 


2150-2169
3493
CCCCAUCCUGGAAGGAGGG
3494
ccccAuccuGGAAGGAGGGdTsdT
sense


 


2150-2169
3495
CCCUCCUUCCAGGAUGGGG
3496
CCCUCCUUCcAGGAUGGGGdTsdT
antis


 


2152-2171
3497
CCAUCCUGGAAGGAGGGGA
3498
ccAuccuGGAAGGAGGGGAdTsdT
sense


 


2152-2171
3499
UCCCCUCCUUCCAGGAUGG
3500
UCCCCUCCUUCcAGGAUGGdTsdT
antis


 


2156-2175
3501
CCUGGAAGGAGGGGAGUAG
3502
ccuGGAAGGAGGGGAGuAGdTsdT
sense


 


2156-2175
3503
CUACUCCCCUCCUUCCAGG
3504
CuACUCCCCUCCUUCcAGGdTsdT
antis


 


2161-2180
3505
AAGGAGGGGAGUAGAGAGA
3506
AAGGAGGGGAGuAGAGAGAdTsdT
sense


 


2161-2180
3507
UCUCUCUACUCCCCUCCUU
3508
UCUCUCuACUCCCCUCCUUdTsdT
antis


 


2208-2227
3509
GGUUUGCCUGUGUACAGAC
3510
GGuuuGccuGuGuAcAGAcdTsdT
sense


 


2208-2227
3511
GUCUGUACACAGGCAAACC
3512
GUCUGuAcAcAGGcAAACCdTsdT
antis


 


2219-2238
3513
GUACAGACCUCUGUUCAAU
3514
GuAcAGAccucuGuucAAudTsdT
sense


 


2219-2238
3515
AUUGAACAGAGGUCUGUAC
3516
AUUGAAcAGAGGUCUGuACdTsdT
antis


 


2233-2252
3517
UCAAUAAAUUAUUGGCAUG
3518
ucAAuAAAuuAuuGGcAuGdTsdT
sense


 


2233-2252
3519
CAUGCCAAUAAUUUAUUGA
3520
cAUGCcAAuAAUUuAUUGAdTsdT
antis


 


 2-21
3521
UGGUGACAACGAAGCCGAC
3522
uGGuGAcAAcGAAGccGAcdTsdT
sense


 


 2-21
3523
GUCGGCUUCGUUGUCACCA
3524
GUCGGCUUCGUUGUcACcAdTsdT
antis


 


138-157
3525
GCGGGGGCAGCCCAGGCAG
3526
GcGGGGGcAGcccAGGcAGdTsdT
sense


 


138-157
3527
CUGCCUGGGCUGCCCCCGC
3528
CUGCCUGGGCUGCCCCCGCdTsdT
antis


 


381-400
3529
AGCUCCGGGGGUGGCCCCA
3530
AGcuccGGGGGuGGccccAdTsdT
sense


 


381-400
3531
UGGGGCCACCCCCGGAGCU
3532
UGGGGCcACCCCCGGAGCUdTsdT
antis


 


592-611
3533
ACCAGGCACGGCUGGCAGA
3534
AccAGGcAcGGcuGGcAGAdTsdT
sense


 


592-611
3535
UCUGCCAGCCGUGCCUGGU
3536
UCUGCcAGCCGUGCCUGGUdTsdT
antis


 


615-634
3537
AGGGAACUGGUGGCCAUCA
3538
AGGGAAcuGGuGGccAucAdTsdT
sense


 


615-634
3539
UGAUGGCCACCAGUUCCCU
3540
UGAUGGCcACcAGUUCCCUdTsdT
antis


 


1026-1045
3541
UACAUCUGCUCUCGGUACU
3542
uAcAucuGcucucGGuAcudTsdT
sense


 


1026-1045
3543
AGUACCGAGAGCAGAUGUA
3544
AGuACCGAGAGcAGAUGuAdTsdT
antis


 


1027-1046
3545
ACAUCUGCUCUCGGUACUA
3546
AcAucuGcucucGGuAcuAdTsdT
sense


 


1027-1046
3547
UAGUACCGAGAGCAGAUGU
3548
uAGuACCGAGAGcAGAUGUdTsdT
antis


 


1105-1124
3549
CGGCUGGCUGUGUACUUGC
3550
cGGcuGGcuGuGuAcuuGcdTsdT
sense


 


1105-1124
3551
GCAAGUACACAGCCAGCCG
3552
GcAAGuAcAcAGCcAGCCGdTsdT
antis


 


1362-1381
3553
UCAAGGCUCUCCCCACUCG
3554
ucAAGGcucuccccAcucGdTsdT
sense


 


1362-1381
3555
CGAGUGGGGAGAGCCUUGA
3556
CGAGUGGGGAGAGCCUUGAdTsdT
antis


 


1440-1459
3557
GACCGCCCGCUUCCCCCCC
3558
GAccGcccGcuucccccccdTsdT
sense


 


1440-1459
3559
GGGGGGGAAGCGGGCGGUC
3560
GGGGGGGAAGCGGGCGGUCdTsdT
antis


 


2017-2036
3561
CCCUUCCCUGGCCCCCUGG
3562
cccuucccuGGcccccuGGdTsdT
sense


 


2017-2036
3563
CCAGGGGGCCAGGGAAGGG
3564
CcAGGGGGCcAGGGAAGGGdTsdT
antis


 


2018-2037
3565
CCUUCCCUGGCCCCCUGGG
3566
ccuucccuGGcccccuGGGdTsdT
sense


 


2018-2037
3567
CCCAGGGGGCCAGGGAAGG
3568
CCcAGGGGGCcAGGGAAGGdTsdT
antis


 


2019-2038
3569
CUUCCCUGGCCCCCUGGGU
3570
cuucccuGGcccccuGGGudTsdT
sense


 


2019-2038
3571
ACCCAGGGGGCCAGGGAAG
3572
ACCcAGGGGGCcAGGGAAGdTsdT
antis


 


2148-2167
3573
CUCCCCAUCCUGGAAGGAG
3574
cuccccAuccuGGAAGGAGdTsdT
sense


 


2148-2167
3575
CUCCUUCCAGGAUGGGGAG
3576
CUCCUUCcAGGAUGGGGAGdTsdT
antis


 


2149-2168
3577
UCCCCAUCCUGGAAGGAGG
3578
uccccAuccuGGAAGGAGGdTsdT
sense


 


2149-2168
3579
CCUCCUUCCAGGAUGGGGA
3580
CCUCCUUCcAGGAUGGGGAdTsdT
antis


 


1335-1354
3581
UCUAGCCUACUGGAGUACA
3582
ucuAGccuAcuGGAGuAcAdTsdT
sense


 


1335-1354
3583
UGUACUCCAGUAGGCUAGA
3584
UGuACUCcAGuAGGCuAGAdTsdT
antis


 


342-361
3585
GCGUCAGUCGGGGCUAUGG
3586
GcGucAGucGGGGcuAuGGdTsdT
sense


 


342-361
3587
CCAUAGCCCCGACUGACGC
3588
CcAuAGCCCCGACUGACGCdTsdT
antis


 


675-694
3589
CAGAUUAUGCGUAAGCUGG
3590
cAGAuuAuGcGuAAGcuGGdTsdT
sense


 


675-694
3591
CCAGCUUACGCAUAAUCUG
3592
CcAGCUuACGcAuAAUCUGdTsdT
antis


 


1080-1099
3593
UACACCUCGUCCAUCGAUG
3594
uAcAccucGuccAucGAuGdTsdT
sense


 


1080-1099
3595
CAUCGAUGGACGAGGUGUA
3596
cAUCGAUGGACGAGGUGuAdTsdT
antis


 


333-352
3597
GGCGGGAAAGCGUCAGUCG
3598
GGcGGGAAAGcGucAGucGdTsdT
sense


 


333-352
3599
CGACUGACGCUUUCCCGCC
3600
CGACUGACGCUUUCCCGCCdTsdT
antis


 


475-494
3601
GUGACAGCGGGAAGGUGAC
3602
GuGAcAGcGGGAAGGuGAcdTsdT
sense


 


475-494
3603
GUCACCUUCCCGCUGUCAC
3604
GUcACCUUCCCGCUGUcACdTsdT
antis


 


533-552
3605
CCAAGAAGUGGCUUACACU
3606
ccAAGAAGuGGcuuAcAcudTsdT
sense


 


533-552
3607
AGUGUAAGCCACUUCUUGG
3608
AGUGuAAGCcACUUCUUGGdTsdT
antis


 


746-765
3609
GAAGGACGAGCUGUAUUUG
3610
GAAGGAcGAGcuGuAuuuGdTsdT
sense


 


746-765
3611
CAAAUACAGCUCGUCCUUC
3612
cAAAuAcAGCUCGUCCUUCdTsdT
antis


 


747-766
3613
AAGGACGAGCUGUAUUUGA
3614
AAGGAcGAGcuGuAuuuGAdTsdT
sense


 


747-766
3615
UCAAAUACAGCUCGUCCUU
3616
UcAAAuAcAGCUCGUCCUUdTsdT
antis


 


830-849
3617
GCUGAUCACCCCUAUCAUC
3618
GcuGAucAccccuAucAucdTsdT
sense


 


830-849
3619
GAUGAUAGGGGUGAUCAGC
3620
GAUGAuAGGGGUGAUcAGCdTsdT
antis


 


1334-1353
3621
CUCUAGCCUACUGGAGUAC
3622
cucuAGccuAcuGGAGuAcdTsdT
sense


 


1334-1353
3623
GUACUCCAGUAGGCUAGAG
3624
GuACUCcAGuAGGCuAGAGdTsdT
antis


 


497-516
3625
AGUGGUAGCCACUGUAGGC
3626
AGuGGuAGccAcuGuAGGcdTsdT
sense


 


497-516
3627
GCCUACAGUGGCUACCACU
3628
GCCuAcAGUGGCuACcACUdTsdT
antis


 


1641-1660
3629
GCUACCCUCGCUAGCUCUU
3630
GcuAcccucGcuAGcucuudTsdT
sense


 


1641-1660
3631
AAGAGCUAGCGAGGGUAGC
3632
AAGAGCuAGCGAGGGuAGCdTsdT
antis


 


1642-1661
3633
CUACCCUCGCUAGCUCUUC
3634
cuAcccucGcuAGcucuucdTsdT
sense


 


1642-1661
3635
GAAGAGCUAGCGAGGGUAG
3636
GAAGAGCuAGCGAGGGuAGdTsdT
antis


 


676-695
3637
AGAUUAUGCGUAAGCUGGA
3638
AGAuuAuGcGuAAGcuGGAdTsdT
sense


 


676-695
3639
UCCAGCUUACGCAUAAUCU
3640
UCcAGCUuACGcAuAAUCUdTsdT
antis


 


1128-1147
3641
CUACUUCUCGGCCAGCCCA
3642
cuAcuucucGGccAGcccAdTsdT
sense


 


1128-1147
3643
UGGGCUGGCCGAGAAGUAG
3644
UGGGCUGGCCGAGAAGuAGdTsdT
antis


 


40-59
3645
CCGGCGUGCCCCGCGGCGG
3646
ccGGcGuGccccGcGGcGGdTsdT
sense


 


40-59
3647
CCGCCGCGGGGCACGCCGG
3648
CCGCCGCGGGGcACGCCGGdTsdT
antis


 


199-218
3649
GCGGCGGGCCUUCGGGAGG
3650
GcGGcGGGccuucGGGAGGdTsdT
sense


 


199-218
3651
CCUCCCGAAGGCCCGCCGC
3652
CCUCCCGAAGGCCCGCCGCdTsdT
antis


 


222-241
3653
CCUGGGGGCUCGGGCCGGG
3654
ccuGGGGGcucGGGccGGGdTsdT
sense


 


222-241
3655
CCCGGCCCGAGCCCCCAGG
3656
CCCGGCCCGAGCCCCcAGGdTsdT
antis


 


343-362
3657
CGUCAGUCGGGGCUAUGGG
3658
cGucAGucGGGGcuAuGGGdTsdT
sense


 


343-362
3659
CCCAUAGCCCCGACUGACG
3660
CCcAuAGCCCCGACUGACGdTsdT
antis


 


437-456
3661
GGGCACUAGCUUCCCGCCG
3662
GGGcAcuAGcuucccGccGdTsdT
sense


 


437-456
3663
CGGCGGGAAGCUAGUGCCC
3664
CGGCGGGAAGCuAGUGCCCdTsdT
antis


 


538-557
3665
AAGUGGCUUACACUGACAU
3666
AAGuGGcuuAcAcuGAcAudTsdT
sense


 


538-557
3667
AUGUCAGUGUAAGCCACUU
3668
AUGUcAGUGuAAGCcACUUdTsdT
antis


 


663-682
3669
AACCGAGAACUGCAGAUUA
3670
AAccGAGAAcuGcAGAuuAdTsdT
sense


 


663-682
3671
UAAUCUGCAGUUCUCGGUU
3672
uAAUCUGcAGUUCUCGGUUdTsdT
antis


 


887-906
3673
GGCCUACAUCCACUCCCAA
3674
GGccuAcAuccAcucccAAdTsdT
sense


 


887-906
3675
UUGGGAGUGGAUGUAGGCC
3676
UUGGGAGUGGAUGuAGGCCdTsdT
antis


 


 997-1016
3677
AGCUGGUUCGGGGGGAGCC
3678
AGcuGGuucGGGGGGAGccdTsdT
sense


 


 997-1016
3679
GGCUCCCCCCGAACCAGCU
3680
GGCUCCCCCCGAACcAGCUdTsdT
antis


 


1079-1098
3681
UUACACCUCGUCCAUCGAU
3682
uuAcAccucGuccAucGAudTsdT
sense


 


1079-1098
3683
AUCGAUGGACGAGGUGUAA
3684
AUCGAUGGACGAGGUGuAAdTsdT
antis


 


1323-1342
3685
AUUGCACUCUGCUCUAGCC
3686
AuuGcAcucuGcucuAGccdTsdT
sense


 


1323-1342
3687
GGCUAGAGCAGAGUGCAAU
3688
GGCuAGAGcAGAGUGcAAUdTsdT
antis


 


1370-1389
3689
CUCCCCACUCGAGGCUUGU
3690
cuccccAcucGAGGcuuGudTsdT
sense


 


1370-1389
3691
ACAAGCCUCGAGUGGGGAG
3692
AcAAGCCUCGAGUGGGGAGdTsdT
antis


 


1494-1513
3693
CCAUCUCUCAAUGCCAUUC
3694
ccAucucucAAuGccAuucdTsdT
sense


 


1494-1513
3695
GAAUGGCAUUGAGAGAUGG
3696
GAAUGGcAUUGAGAGAUGGdTsdT
antis


 


57-76
3697
GGGCGCUGGGCCGGAGCCG
3698
GGGcGcuGGGccGGAGccGdTsdT
sense


 


57-76
3699
CGGCUCCGGCCCAGCGCCC
3700
CGGCUCCGGCCcAGCGCCCdTsdT
antis


 


137-156
3701
GGCGGGGGCAGCCCAGGCA
3702
GGcGGGGGcAGcccAGGcAdTsdT
sense


 


137-156
3703
UGCCUGGGCUGCCCCCGCC
3704
UGCCUGGGCUGCCCCCGCCdTsdT
antis


 


141-160
3705
GGGGCAGCCCAGGCAGCCC
3706
GGGGcAGcccAGGcAGcccdTsdT
sense


 


141-160
3707
GGGCUGCCUGGGCUGCCCC
3708
GGGCUGCCUGGGCUGCCCCdTsdT
antis


 


198-217
3709
GGCGGCGGGCCUUCGGGAG
3710
GGcGGcGGGccuucGGGAGdTsdT
sense


 


198-217
3711
CUCCCGAAGGCCCGCCGCC
3712
CUCCCGAAGGCCCGCCGCCdTsdT
antis


 


319-338
3713
CAGGAGGCACUGGCGGCGG
3714
cAGGAGGcAcuGGcGGcGGdTsdT
sense


 


319-338
3715
CCGCCGCCAGUGCCUCCUG
3716
CCGCCGCcAGUGCCUCCUGdTsdT
antis


 


417-436
3717
GGCAGCGGUGGCCCCGGCG
3718
GGcAGcGGuGGccccGGcGdTsdT
sense


 


417-436
3719
CGCCGGGGCCACCGCUGCC
3720
CGCCGGGGCcACCGCUGCCdTsdT
antis


 


490-509
3721
UGACCACAGUGGUAGCCAC
3722
uGAccAcAGuGGuAGccAcdTsdT
sense


 


490-509
3723
GUGGCUACCACUGUGGUCA
3724
GUGGCuACcACUGUGGUcAdTsdT
antis


 


503-522
3725
AGCCACUGUAGGCCAAGGC
3726
AGccAcuGuAGGccAAGGcdTsdT
sense


 


503-522
3727
GCCUUGGCCUACAGUGGCU
3728
GCCUUGGCCuAcAGUGGCUdTsdT
antis


 


539-558
3729
AGUGGCUUACACUGACAUC
3730
AGuGGcuuAcAcuGAcAucdTsdT
sense


 


539-558
3731
GAUGUCAGUGUAAGCCACU
3732
GAUGUcAGUGuAAGCcACUdTsdT
antis


 


602-621
3733
GCUGGCAGAGACGAGGGAA
3734
GcuGGcAGAGAcGAGGGAAdTsdT
sense


 


602-621
3735
UUCCCUCGUCUCUGCCAGC
3736
UUCCCUCGUCUCUGCcAGCdTsdT
antis


 


793-812
3737
CGGUGUACCGAGUGGCCCG
3738
cGGuGuAccGAGuGGcccGdTsdT
sense


 


793-812
3739
CGGGCCACUCGGUACACCG
3740
CGGGCcACUCGGuAcACCGdTsdT
antis


 


825-844
3741
GCCAAGCUGAUCACCCCUA
3742
GccAAGcuGAucAccccuAdTsdT
sense


 


825-844
3743
UAGGGGUGAUCAGCUUGGC
3744
uAGGGGUGAUcAGCUUGGCdTsdT
antis


 


829-848
3745
AGCUGAUCACCCCUAUCAU
3746
AGcuGAucAccccuAucAudTsdT
sense


 


829-848
3747
AUGAUAGGGGUGAUCAGCU
3748
AUGAuAGGGGUGAUcAGCUdTsdT
antis


 


843-862
3749
AUCAUCUACAUCAAGGUGU
3750
AucAucuAcAucAAGGuGudTsdT
sense


 


843-862
3751
ACACCUUGAUGUAGAUGAU
3752
AcACCUUGAUGuAGAUGAUdTsdT
antis


 


844-863
3753
UCAUCUACAUCAAGGUGUA
3754
ucAucuAcAucAAGGuGuAdTsdT
sense


 


844-863
3755
UACACCUUGAUGUAGAUGA
3756
uAcACCUUGAUGuAGAUGAdTsdT
antis


 


888-907
3757
GCCUACAUCCACUCCCAAG
3758
GccuAcAuccAcucccAAGdTsdT
sense


 


888-907
3759
CUUGGGAGUGGAUGUAGGC
3760
CUUGGGAGUGGAUGuAGGCdTsdT
antis


 


902-921
3761
CCAAGGUGUGUGUCACCGU
3762
ccAAGGuGuGuGucAccGudTsdT
sense


 


902-921
3763
ACGGUGACACACACCUUGG
3764
ACGGUGAcAcAcACCUUGGdTsdT
antis


 


1067-1086
3765
UGGAGCCACAGAUUACACC
3766
uGGAGccAcAGAuuAcAccdTsdT
sense


 


1067-1086
3767
GGUGUAAUCUGUGGCUCCA
3768
GGUGuAAUCUGUGGCUCcAdTsdT
antis


 


1095-1114
3769
GAUGUGUGGUCGGCUGGCU
3770
GAuGuGuGGucGGcuGGcudTsdT
sense


 


1095-1114
3771
AGCCAGCCGACCACACAUC
3772
AGCcAGCCGACcAcAcAUCdTsdT
antis


 


1154-1173
3773
UGGGGACAGUGGGGUGGAC
3774
uGGGGAcAGuGGGGuGGAcdTsdT
sense


 


1154-1173
3775
GUCCACCCCACUGUCCCCA
3776
GUCcACCCcACUGUCCCcAdTsdT
antis


 


1271-1290
3777
AGCUCACCCUUGGACAAAG
3778
AGcucAcccuuGGAcAAAGdTsdT
sense


 


1271-1290
3779
CUUUGUCCAAGGGUGAGCU
3780
CUUUGUCcAAGGGUGAGCUdTsdT
antis


 


1272-1291
3781
GCUCACCCUUGGACAAAGG
3782
GcucAcccuuGGAcAAAGGdTsdT
sense


 


1272-1291
3783
CCUUUGUCCAAGGGUGAGC
3784
CCUUUGUCcAAGGGUGAGCdTsdT
antis


 


1289-1308
3785
GGUGUUCAAAUCUUCAAAG
3786
GGuGuucAAAucuucAAAGdTsdT
sense


 


1289-1308
3787
CUUUGAAGAUUUGAACACC
3788
CUUUGAAGAUUUGAAcACCdTsdT
antis


 


1324-1343
3789
UUGCACUCUGCUCUAGCCU
3790
uuGcAcucuGcucuAGccudTsdT
sense


 


1324-1343
3791
AGGCUAGAGCAGAGUGCAA
3792
AGGCuAGAGcAGAGUGcAAdTsdT
antis


 


1351-1370
3793
ACACGCCAUCCUCAAGGCU
3794
AcAcGccAuccucAAGGcudTsdT
sense


 


1351-1370
3795
AGCCUUGAGGAUGGCGUGU
3796
AGCCUUGAGGAUGGCGUGUdTsdT
antis


 


1371-1390
3797
UCCCCACUCGAGGCUUGUG
3798
uccccAcucGAGGcuuGuGdTsdT
sense


 


1371-1390
3799
CACAAGCCUCGAGUGGGGA
3800
cAcAAGCCUCGAGUGGGGAdTsdT
antis


 


1392-1411
3801
CACAGCUUCUUCGAUGAAC
3802
cAcAGcuucuucGAuGAAcdTsdT
sense


 


1392-1411
3803
GUUCAUCGAAGAAGCUGUG
3804
GUUcAUCGAAGAAGCUGUGdTsdT
antis


 


1395-1414
3805
AGCUUCUUCGAUGAACUGC
3806
AGcuucuucGAuGAAcuGcdTsdT
sense


 


1395-1414
3807
GCAGUUCAUCGAAGAAGCU
3808
GcAGUUcAUCGAAGAAGCUdTsdT
antis


 


1439-1458
3809
CGACCGCCCGCUUCCCCCC
3810
cGAccGcccGcuuccccccdTsdT
sense


 


1439-1458
3811
GGGGGGAAGCGGGCGGUCG
3812
GGGGGGAAGCGGGCGGUCGdTsdT
antis


 


1442-1461
3813
CCGCCCGCUUCCCCCCCUG
3814
ccGcccGcuucccccccuGdTsdT
sense


 


1442-1461
3815
CAGGGGGGGAAGCGGGCGG
3816
cAGGGGGGGAAGCGGGCGGdTsdT
antis


 


1467-1486
3817
UUCAGUCCUGGUGAACUGU
3818
uucAGuccuGGuGAAcuGudTsdT
sense


 


1467-1486
3819
ACAGUUCACCAGGACUGAA
3820
AcAGUUcACcAGGACUGAAdTsdT
antis


 


1468-1487
3821
UCAGUCCUGGUGAACUGUC
3822
ucAGuccuGGuGAAcuGucdTsdT
sense


 


1468-1487
3823
GACAGUUCACCAGGACUGA
3824
GAcAGUUcACcAGGACUGAdTsdT
antis


 


1482-1501
3825
CUGUCCAUCCAACCAUCUC
3826
cuGuccAuccAAccAucucdTsdT
sense


 


1482-1501
3827
GAGAUGGUUGGAUGGACAG
3828
GAGAUGGUUGGAUGGAcAGdTsdT
antis


 


1483-1502
3829
UGUCCAUCCAACCAUCUCU
3830
uGuccAuccAAccAucucudTsdT
sense


 


1483-1502
3831
AGAGAUGGUUGGAUGGACA
3832
AGAGAUGGUUGGAUGGAcAdTsdT
antis


 


1495-1514
3833
CAUCUCUCAAUGCCAUUCU
3834
cAucucucAAuGccAuucudTsdT
sense


 


1495-1514
3835
AGAAUGGCAUUGAGAGAUG
3836
AGAAUGGcAUUGAGAGAUGdTsdT
antis


 


1554-1573
3837
CCCCUCACCACUUCCUACA
3838
ccccucAccAcuuccuAcAdTsdT
sense


 


1554-1573
3839
UGUAGGAAGUGGUGAGGGG
3840
UGuAGGAAGUGGUGAGGGGdTsdT
antis


 


1597-1616
3841
AAGCUCAGACUGGCCAAGA
3842
AAGcucAGAcuGGccAAGAdTsdT
sense


 


1597-1616
3843
UCUUGGCCAGUCUGAGCUU
3844
UCUUGGCcAGUCUGAGCUUdTsdT
antis


 


1659-1678
3845
UCCUGAGGGCCCCACCGAC
3846
uccuGAGGGccccAccGAcdTsdT
sense


 


1659-1678
3847
GUCGGUGGGGCCCUCAGGA
3848
GUCGGUGGGGCCCUcAGGAdTsdT
antis


 


1814-1833
3849
CAGCAGCCUAACCUCUGUG
3850
cAGcAGccuAAccucuGuGdTsdT
sense


 


1814-1833
3851
CACAGAGGUUAGGCUGCUG
3852
cAcAGAGGUuAGGCUGCUGdTsdT
antis


 


1815-1834
3853
AGCAGCCUAACCUCUGUGG
3854
AGcAGccuAAccucuGuGGdTsdT
sense


 


1815-1834
3855
CCACAGAGGUUAGGCUGCU
3856
CcAcAGAGGUuAGGCUGCUdTsdT
antis


 


1904-1923
3857
UGAGGACCUUCUACCCCCU
3858
uGAGGAccuucuAcccccudTsdT
sense


 


1904-1923
3859
AGGGGGUAGAAGGUCCUCA
3860
AGGGGGuAGAAGGUCCUcAdTsdT
antis


 


1905-1924
3861
GAGGACCUUCUACCCCCUU
3862
GAGGAccuucuAcccccuudTsdT
sense


 


1905-1924
3863
AAGGGGGUAGAAGGUCCUC
3864
AAGGGGGuAGAAGGUCCUCdTsdT
antis


 


2012-2031
3865
GUCUUCCCUUCCCUGGCCC
3866
GucuucccuucccuGGcccdTsdT
sense


 


2012-2031
3867
GGGCCAGGGAAGGGAAGAC
3868
GGGCcAGGGAAGGGAAGACdTsdT
antis


 


2095-2114
3869
UGCCCCCCCCAGCUGUACC
3870
uGccccccccAGcuGuAccdTsdT
sense


 


2095-2114
3871
GGUACAGCUGGGGGGGGCA
3872
GGuAcAGCUGGGGGGGGcAdTsdT
antis


 


2102-2121
3873
CCCAGCUGUACCCCUUCUU
3874
cccAGcuGuAccccuucuudTsdT
sense


 


2102-2121
3875
AAGAAGGGGUACAGCUGGG
3876
AAGAAGGGGuAcAGCUGGGdTsdT
antis


 


2184-2203
3877
CUGGUGUCUUAGUUUCCAC
3878
cuGGuGucuuAGuuuccAcdTsdT
sense


 


2184-2203
3879
GUGGAAACUAAGACACCAG
3880
GUGGAAACuAAGAcACcAGdTsdT
antis


 


2192-2211
3881
UUAGUUUCCACAGUAAGGU
3882
uuAGuuuccAcAGuAAGGudTsdT
sense


 


2192-2211
3883
ACCUUACUGUGGAAACUAA
3884
ACCUuACUGUGGAAACuAAdTsdT
antis


 


2227-2246
3885
CUCUGUUCAAUAAAUUAUU
3886
cucuGuucAAuAAAuuAuudTsdT
sense


 


2227-2246
3887
AAUAAUUUAUUGAACAGAG
3888
AAuAAUUuAUUGAAcAGAGdTsdT
antis


 


151-170
3889
AGGCAGCCCGAGCCCCGCG
3890
AGGcAGcccGAGccccGcGdTsdT
sense


 


151-170
3891
CGCGGGGCUCGGGCUGCCU
3892
CGCGGGGCUCGGGCUGCCUdTsdT
antis


 


404-423
3893
CAGCGGCGGAGGAGGCAGC
3894
cAGcGGcGGAGGAGGcAGcdTsdT
sense


 


404-423
3895
GCUGCCUCCUCCGCCGCUG
3896
GCUGCCUCCUCCGCCGCUGdTsdT
antis


 


530-549
3897
UUCCCAAGAAGUGGCUUAC
3898
uucccAAGAAGuGGcuuAcdTsdT
sense


 


530-549
3899
GUAAGCCACUUCUUGGGAA
3900
GuAAGCcACUUCUUGGGAAdTsdT
antis


 


954-973
3901
GACACUGCUGUCCUCAAGC
3902
GAcAcuGcuGuccucAAGcdTsdT
sense


 


954-973
3903
GCUUGAGGACAGCAGUGUC
3904
GCUUGAGGAcAGcAGUGUCdTsdT
antis


 


1394-1413
3905
CAGCUUCUUCGAUGAACUG
3906
cAGcuucuucGAuGAAcuGdTsdT
sense


 


1394-1413
3907
CAGUUCAUCGAAGAAGCUG
3908
cAGUUcAUCGAAGAAGCUGdTsdT
antis


 


2002-2021
3909
CCCAUCUCUCGUCUUCCCU
3910
cccAucucucGucuucccudTsdT
sense


 


2002-2021
3911
AGGGAAGACGAGAGAUGGG
3912
AGGGAAGACGAGAGAUGGGdTsdT
antis


 


2003-2022
3913
CCAUCUCUCGUCUUCCCUU
3914
ccAucucucGucuucccuudTsdT
sense


 


2003-2022
3915
AAGGGAAGACGAGAGAUGG
3916
AAGGGAAGACGAGAGAUGGdTsdT
antis


 


2121-2140
3917
GUCCUCUGCUCCCAAGGCU
3918
GuccucuGcucccAAGGcudTsdT
sense


 


2121-2140
3919
AGCCUUGGGAGCAGAGGAC
3920
AGCCUUGGGAGcAGAGGACdTsdT
antis


 


24-43
3921
AGAGGGACUUCAUCUCCCG
3922
AGAGGGAcuucAucucccGdTsdT
sense


 


24-43
3923
CGGGAGAUGAAGUCCCUCU
3924
CGGGAGAUGAAGUCCCUCUdTsdT
antis


 


49-68
3925
CCCGCGGCGGGCGCUGGGC
3926
cccGcGGcGGGcGcuGGGcdTsdT
sense


 


49-68
3927
GCCCAGCGCCCGCCGCGGG
3928
GCCcAGCGCCCGCCGCGGGdTsdT
antis


 


107-126
3929
GAGCCCAGGGGAGGCGGCG
3930
GAGcccAGGGGAGGcGGcGdTsdT
sense


 


107-126
3931
CGCCGCCUCCCCUGGGCUC
3932
CGCCGCCUCCCCUGGGCUCdTsdT
antis


 


126-145
3933
GCAGAGGCAGCGGCGGGGG
3934
GcAGAGGcAGcGGcGGGGGdTsdT
sense


 


126-145
3935
CCCCCGCCGCUGCCUCUGC
3936
CCCCCGCCGCUGCCUCUGCdTsdT
antis


 


153-172
3937
GCAGCCCGAGCCCCGCGGC
3938
GcAGcccGAGccccGcGGcdTsdT
sense


 


153-172
3939
GCCGCGGGGCUCGGGCUGC
3940
GCCGCGGGGCUCGGGCUGCdTsdT
antis


 


259-278
3941
CGGAGCCAGGAGGCGGAGG
3942
cGGAGccAGGAGGcGGAGGdTsdT
sense


 


259-278
3943
CCUCCGCCUCCUGGCUCCG
3944
CCUCCGCCUCCUGGCUCCGdTsdT
antis


 


261-280
3945
GAGCCAGGAGGCGGAGGCG
3946
GAGccAGGAGGcGGAGGcGdTsdT
sense


 


261-280
3947
CGCCUCCGCCUCCUGGCUC
3948
CGCCUCCGCCUCCUGGCUCdTsdT
antis


 


512-531
3949
AGGCCAAGGCCCAGAGCGU
3950
AGGccAAGGcccAGAGcGudTsdT
sense


 


512-531
3951
ACGCUCUGGGCCUUGGCCU
3952
ACGCUCUGGGCCUUGGCCUdTsdT
antis


 


660-679
3953
AAGAACCGAGAACUGCAGA
3954
AAGAAccGAGAAcuGcAGAdTsdT
sense


 


660-679
3955
UCUGCAGUUCUCGGUUCUU
3956
UCUGcAGUUCUCGGUUCUUdTsdT
antis


 


709-728
3957
UGAGGCUGCGGUACUUUUU
3958
uGAGGcuGcGGuAcuuuuudTsdT
sense


 


709-728
3959
AAAAAGUACCGCAGCCUCA
3960
AAAAAGuACCGcAGCCUcAdTsdT
antis


 


710-729
3961
GAGGCUGCGGUACUUUUUC
3962
GAGGcuGcGGuAcuuuuucdTsdT
sense


 


710-729
3963
GAAAAAGUACCGCAGCCUC
3964
GAAAAAGuACCGcAGCCUCdTsdT
antis


 


792-811
3965
ACGGUGUACCGAGUGGCCC
3966
AcGGuGuAccGAGuGGcccdTsdT
sense


 


792-811
3967
GGGCCACUCGGUACACCGU
3968
GGGCcACUCGGuAcACCGUdTsdT
antis


 


903-922
3969
CAAGGUGUGUGUCACCGUG
3970
cAAGGuGuGuGucAccGuGdTsdT
sense


 


903-922
3971
CACGGUGACACACACCUUG
3972
cACGGUGAcAcAcACCUUGdTsdT
antis


 


1110-1129
3973
GGCUGUGUACUUGCUGAGC
3974
GGcuGuGuAcuuGcuGAGcdTsdT
sense


 


1110-1129
3975
GCUCAGCAAGUACACAGCC
3976
GCUcAGcAAGuAcAcAGCCdTsdT
antis


 


1129-1148
3977
UACUUCUCGGCCAGCCCAU
3978
uAcuucucGGccAGcccAudTsdT
sense


 


1129-1148
3979
AUGGGCUGGCCGAGAAGUA
3980
AUGGGCUGGCCGAGAAGuAdTsdT
antis


 


1142-1161
3981
GCCCAUCUUCCCUGGGGAC
3982
GcccAucuucccuGGGGAcdTsdT
sense


 


1142-1161
3983
GUCCCCAGGGAAGAUGGGC
3984
GUCCCcAGGGAAGAUGGGCdTsdT
antis


 


1153-1172
3985
CUGGGGACAGUGGGGUGGA
3986
cuGGGGAcAGuGGGGuGGAdTsdT
sense


 


1153-1172
3987
UCCACCCCACUGUCCCCAG
3988
UCcACCCcACUGUCCCcAGdTsdT
antis


 


1472-1491
3989
UCCUGGUGAACUGUCCAUC
3990
uccuGGuGAAcuGuccAucdTsdT
sense


 


1472-1491
3991
GAUGGACAGUUCACCAGGA
3992
GAUGGAcAGUUcACcAGGAdTsdT
antis


 


1473-1492
3993
CCUGGUGAACUGUCCAUCC
3994
ccuGGuGAAcuGuccAuccdTsdT
sense


 


1473-1492
3995
GGAUGGACAGUUCACCAGG
3996
GGAUGGAcAGUUcACcAGGdTsdT
antis


 


1652-1671
3997
UAGCUCUUCCUGAGGGCCC
3998
uAGcucuuccuGAGGGcccdTsdT
sense


 


1652-1671
3999
GGGCCCUCAGGAAGAGCUA
4000
GGGCCCUcAGGAAGAGCuAdTsdT
antis


 


1653-1672
4001
AGCUCUUCCUGAGGGCCCC
4002
AGcucuuccuGAGGGccccdTsdT
sense


 


1653-1672
4003
GGGGCCCUCAGGAAGAGCU
4004
GGGGCCCUcAGGAAGAGCUdTsdT
antis


 


1812-1831
4005
CUCAGCAGCCUAACCUCUG
4006
cucAGcAGccuAAccucuGdTsdT
sense


 


1812-1831
4007
CAGAGGUUAGGCUGCUGAG
4008
cAGAGGUuAGGCUGCUGAGdTsdT
antis


 


1952-1971
4009
UCCUUCCCUCCCCCCCUCU
4010
uccuucccucccccccucudTsdT
sense


 


1952-1971
4011
AGAGGGGGGGAGGGAAGGA
4012
AGAGGGGGGGAGGGAAGGAdTsdT
antis


 


1968-1987
4013
UCUCCCAGGUCCCUUGUAA
4014
ucucccAGGucccuuGuAAdTsdT
sense


 


1968-1987
4015
UUACAAGGGACCUGGGAGA
4016
UuAcAAGGGACCUGGGAGAdTsdT
antis


 


2051-2070
4017
UAUAAUUUUUUCUUAAAGA
4018
uAuAAuuuuuucuuAAAGAdTsdT
sense


 


2051-2070
4019
UCUUUAAGAAAAAAUUAUA
4020
UCUUuAAGAAAAAAUuAuAdTsdT
antis


 


2056-2075
4021
UUUUUUCUUAAAGAAAACG
4022
uuuuuucuuAAAGAAAAcGdTsdT
sense


 


2056-2075
4023
CGUUUUCUUUAAGAAAAAA
4024
CGUUUUCUUuAAGAAAAAAdTsdT
antis


 


2128-2147
4025
GCUCCCAAGGCUUCCUCCC
4026
GcucccAAGGcuuccucccdTsdT
sense


 


2128-2147
4027
GGGAGGAAGCCUUGGGAGC
4028
GGGAGGAAGCCUUGGGAGCdTsdT
antis


 


2135-2154
4029
AGGCUUCCUCCCUCUCCCC
4030
AGGcuuccucccucuccccdTsdT
sense


 


2135-2154
4031
GGGGAGAGGGAGGAAGCCU
4032
GGGGAGAGGGAGGAAGCCUdTsdT
antis


 


2136-2155
4033
GGCUUCCUCCCUCUCCCCA
4034
GGcuuccucccucuccccAdTsdT
sense


 


2136-2155
4035
UGGGGAGAGGGAGGAAGCC
4036
UGGGGAGAGGGAGGAAGCCdTsdT
antis


 


2147-2166
4037
UCUCCCCAUCCUGGAAGGA
4038
ucuccccAuccuGGAAGGAdTsdT
sense


 


2147-2166
4039
UCCUUCCAGGAUGGGGAGA
4040
UCCUUCcAGGAUGGGGAGAdTsdT
antis


 


511-530
4041
UAGGCCAAGGCCCAGAGCG
4042
uAGGccAAGGcccAGAGcGdTsdT
sense


 


511-530
4043
CGCUCUGGGCCUUGGCCUA
4044
CGCUCUGGGCCUUGGCCuAdTsdT
antis


 


677-696
4045
GAUUAUGCGUAAGCUGGAC
4046
GAuuAuGcGuAAGcuGGAcdTsdT
sense


 


677-696
4047
GUCCAGCUUACGCAUAAUC
4048
GUCcAGCUuACGcAuAAUCdTsdT
antis


 


682-701
4049
UGCGUAAGCUGGACCACUG
4050
uGcGuAAGcuGGAccAcuGdTsdT
sense


 


682-701
4051
CAGUGGUCCAGCUUACGCA
4052
cAGUGGUCcAGCUuACGcAdTsdT
antis


 


796-815
4053
UGUACCGAGUGGCCCGCCA
4054
uGuAccGAGuGGcccGccAdTsdT
sense


 


796-815
4055
UGGCGGGCCACUCGGUACA
4056
UGGCGGGCcACUCGGuAcAdTsdT
antis


 


750-769
4057
GACGAGCUGUAUUUGAAUC
4058
GAcGAGcuGuAuuuGAAucdTsdT
sense


 


750-769
4059
GAUUCAAAUACAGCUCGUC
4060
GAUUcAAAuAcAGCUCGUCdTsdT
antis


 


1646-1665
4061
CCUCGCUAGCUCUUCCUGA
4062
ccucGcuAGcucuuccuGAdTsdT
sense


 


1646-1665
4063
UCAGGAAGAGCUAGCGAGG
4064
UcAGGAAGAGCuAGCGAGGdTsdT
antis


 


664-683
4065
ACCGAGAACUGCAGAUUAU
4066
AccGAGAAcuGcAGAuuAudTsdT
sense


 


664-683
4067
AUAAUCUGCAGUUCUCGGU
4068
AuAAUCUGcAGUUCUCGGUdTsdT
antis


 


751-770
4069
ACGAGCUGUAUUUGAAUCU
4070
AcGAGcuGuAuuuGAAucudTsdT
sense


 


751-770
4071
AGAUUCAAAUACAGCUCGU
4072
AGAUUcAAAuAcAGCUCGUdTsdT
antis


 


835-854
4073
UCACCCCUAUCAUCUACAU
4074
ucAccccuAucAucuAcAudTsdT
sense


 


835-854
4075
AUGUAGAUGAUAGGGGUGA
4076
AUGuAGAUGAuAGGGGUGAdTsdT
antis


 


1399-1418
4077
UCUUCGAUGAACUGCGGAG
4078
ucuucGAuGAAcuGcGGAGdTsdT
sense


 


1399-1418
4079
CUCCGCAGUUCAUCGAAGA
4080
CUCCGcAGUUcAUCGAAGAdTsdT
antis


 


2175-2194
4081
AGAGAGUCCCUGGUGUCUU
4082
AGAGAGucccuGGuGucuudTsdT
sense


 


2175-2194
4083
AAGACACCAGGGACUCUCU
4084
AAGAcACcAGGGACUCUCUdTsdT
antis


 


19-38
4085
ACGGCAGAGGGACUUCAUC
4086
AcGGcAGAGGGAcuucAucdTsdT
sense


 


19-38
4087
GAUGAAGUCCCUCUGCCGU
4088
GAUGAAGUCCCUCUGCCGUdTsdT
antis


 


79-98
4089
CCCGAACGGCGCGGCCUGG
4090
cccGAAcGGcGcGGccuGGdTsdT
sense


 


79-98
4091
CCAGGCCGCGCCGUUCGGG
4092
CcAGGCCGCGCCGUUCGGGdTsdT
antis


 


186-205
4093
GGCGCCAUGAGCGGCGGCG
4094
GGcGccAuGAGcGGcGGcGdTsdT
sense


 


186-205
4095
CGCCGCCGCUCAUGGCGCC
4096
CGCCGCCGCUcAUGGCGCCdTsdT
antis


 


187-206
4097
GCGCCAUGAGCGGCGGCGG
4098
GcGccAuGAGcGGcGGcGGdTsdT
sense


 


187-206
4099
CCGCCGCCGCUCAUGGCGC
4100
CCGCCGCCGCUcAUGGCGCdTsdT
antis


 


334-353
4101
GCGGGAAAGCGUCAGUCGG
4102
GcGGGAAAGcGucAGucGGdTsdT
sense


 


334-353
4103
CCGACUGACGCUUUCCCGC
4104
CCGACUGACGCUUUCCCGCdTsdT
antis


 


349-368
4105
UCGGGGCUAUGGGUGGGGG
4106
ucGGGGcuAuGGGuGGGGGdTsdT
sense


 


349-368
4107
CCCCCACCCAUAGCCCCGA
4108
CCCCcACCcAuAGCCCCGAdTsdT
antis


 


451-470
4109
CGCCGCCGGGAGUGAAGCU
4110
cGccGccGGGAGuGAAGcudTsdT
sense


 


451-470
4111
AGCUUCACUCCCGGCGGCG
4112
AGCUUcACUCCCGGCGGCGdTsdT
antis


 


476-495
4113
UGACAGCGGGAAGGUGACC
4114
uGAcAGcGGGAAGGuGAccdTsdT
sense


 


476-495
4115
GGUCACCUUCCCGCUGUCA
4116
GGUcACCUUCCCGCUGUcAdTsdT
antis


 


480-499
4117
AGCGGGAAGGUGACCACAG
4118
AGcGGGAAGGuGAccAcAGdTsdT
sense


 


480-499
4119
CUGUGGUCACCUUCCCGCU
4120
CUGUGGUcACCUUCCCGCUdTsdT
antis


 


481-500
4121
GCGGGAAGGUGACCACAGU
4122
GcGGGAAGGuGAccAcAGudTsdT
sense


 


481-500
4123
ACUGUGGUCACCUUCCCGC
4124
ACUGUGGUcACCUUCCCGCdTsdT
antis


 


516-535
4125
CAAGGCCCAGAGCGUUCCC
4126
cAAGGcccAGAGcGuucccdTsdT
sense


 


516-535
4127
GGGAACGCUCUGGGCCUUG
4128
GGGAACGCUCUGGGCCUUGdTsdT
antis


 


586-605
4129
UAGUAUACCAGGCACGGCU
4130
uAGuAuAccAGGcAcGGcudTsdT
sense


 


586-605
4131
AGCCGUGCCUGGUAUACUA
4132
AGCCGUGCCUGGuAuACuAdTsdT
antis


 


608-627
4133
AGAGACGAGGGAACUGGUG
4134
AGAGAcGAGGGAAcuGGuGdTsdT
sense


 


608-627
4135
CACCAGUUCCCUCGUCUCU
4136
cACcAGUUCCCUCGUCUCUdTsdT
antis


 


662-681
4137
GAACCGAGAACUGCAGAUU
4138
GAAccGAGAAcuGcAGAuudTsdT
sense


 


662-681
4139
AAUCUGCAGUUCUCGGUUC
4140
AAUCUGcAGUUCUCGGUUCdTsdT
antis


 


678-697
4141
AUUAUGCGUAAGCUGGACC
4142
AuuAuGcGuAAGcuGGAccdTsdT
sense


 


678-697
4143
GGUCCAGCUUACGCAUAAU
4144
GGUCcAGCUuACGcAuAAUdTsdT
antis


 


679-698
4145
UUAUGCGUAAGCUGGACCA
4146
uuAuGcGuAAGcuGGAccAdTsdT
sense


 


679-698
4147
UGGUCCAGCUUACGCAUAA
4148
UGGUCcAGCUuACGcAuAAdTsdT
antis


 


680-699
4149
UAUGCGUAAGCUGGACCAC
4150
uAuGcGuAAGcuGGAccAcdTsdT
sense


 


680-699
4151
GUGGUCCAGCUUACGCAUA
4152
GUGGUCcAGCUuACGcAuAdTsdT
antis


 


683-702
4153
GCGUAAGCUGGACCACUGC
4154
GcGuAAGcuGGAccAcuGcdTsdT
sense


 


683-702
4155
GCAGUGGUCCAGCUUACGC
4156
GcAGUGGUCcAGCUuACGCdTsdT
antis


 


714-733
4157
CUGCGGUACUUUUUCUACU
4158
cuGcGGuAcuuuuucuAcudTsdT
sense


 


714-733
4159
AGUAGAAAAAGUACCGCAG
4160
AGuAGAAAAAGuACCGcAGdTsdT
antis


 


715-734
4161
UGCGGUACUUUUUCUACUC
4162
uGcGGuAcuuuuucuAcucdTsdT
sense


 


715-734
4163
GAGUAGAAAAAGUACCGCA
4164
GAGuAGAAAAAGuACCGcAdTsdT
antis


 


754-773
4165
AGCUGUAUUUGAAUCUGGU
4166
AGcuGuAuuuGAAucuGGudTsdT
sense


 


754-773
4167
ACCAGAUUCAAAUACAGCU
4168
ACcAGAUUcAAAuAcAGCUdTsdT
antis


 


795-814
4169
GUGUACCGAGUGGCCCGCC
4170
GuGuAccGAGuGGcccGccdTsdT
sense


 


795-814
4171
GGCGGGCCACUCGGUACAC
4172
GGCGGGCcACUCGGuAcACdTsdT
antis


 


797-816
4173
GUACCGAGUGGCCCGCCAC
4174
GuAccGAGuGGcccGccAcdTsdT
sense


 


797-816
4175
GUGGCGGGCCACUCGGUAC
4176
GUGGCGGGCcACUCGGuACdTsdT
antis


 


799-818
4177
ACCGAGUGGCCCGCCACUU
4178
AccGAGuGGcccGccAcuudTsdT
sense


 


799-818
4179
AAGUGGCGGGCCACUCGGU
4180
AAGUGGCGGGCcACUCGGUdTsdT
antis


 


800-819
4181
CCGAGUGGCCCGCCACUUC
4182
ccGAGuGGcccGccAcuucdTsdT
sense


 


800-819
4183
GAAGUGGCGGGCCACUCGG
4184
GAAGUGGCGGGCcACUCGGdTsdT
antis


 


834-853
4185
AUCACCCCUAUCAUCUACA
4186
AucAccccuAucAucuAcAdTsdT
sense


 


834-853
4187
UGUAGAUGAUAGGGGUGAU
4188
UGuAGAUGAuAGGGGUGAUdTsdT
antis


 


845-864
4189
CAUCUACAUCAAGGUGUAC
4190
cAucuAcAucAAGGuGuAcdTsdT
sense


 


845-864
4191
GUACACCUUGAUGUAGAUG
4192
GuAcACCUUGAUGuAGAUGdTsdT
antis


 


850-869
4193
ACAUCAAGGUGUACAUGUA
4194
AcAucAAGGuGuAcAuGuAdTsdT
sense


 


850-869
4195
UACAUGUACACCUUGAUGU
4196
uAcAUGuAcACCUUGAUGUdTsdT
antis


 


885-904
4197
UUGGCCUACAUCCACUCCC
4198
uuGGccuAcAuccAcucccdTsdT
sense


 


885-904
4199
GGGAGUGGAUGUAGGCCAA
4200
GGGAGUGGAUGuAGGCcAAdTsdT
antis


 


890-909
4201
CUACAUCCACUCCCAAGGU
4202
cuAcAuccAcucccAAGGudTsdT
sense


 


890-909
4203
ACCUUGGGAGUGGAUGUAG
4204
ACCUUGGGAGUGGAUGuAGdTsdT
antis


 


921-940
4205
GACAUCAAGCCCCAGAAUU
4206
GAcAucAAGccccAGAAuudTsdT
sense


 


921-940
4207
AAUUCUGGGGCUUGAUGUC
4208
AAUUCUGGGGCUUGAUGUCdTsdT
antis


 


934-953
4209
AGAAUUUGCUUGUGGACCC
4210
AGAAuuuGcuuGuGGAcccdTsdT
sense


 


934-953
4211
GGGUCCACAAGCAAAUUCU
4212
GGGUCcAcAAGcAAAUUCUdTsdT
antis


 


1032-1051
4213
UGCUCUCGGUACUACCGUG
4214
uGcucucGGuAcuAccGuGdTsdT
sense


 


1032-1051
4215
CACGGUAGUACCGAGAGCA
4216
cACGGuAGuACCGAGAGcAdTsdT
antis


 


1033-1052
4217
GCUCUCGGUACUACCGUGC
4218
GcucucGGuAcuAccGuGcdTsdT
sense


 


1033-1052
4219
GCACGGUAGUACCGAGAGC
4220
GcACGGuAGuACCGAGAGCdTsdT
antis


 


1081-1100
4221
ACACCUCGUCCAUCGAUGU
4222
AcAccucGuccAucGAuGudTsdT
sense


 


1081-1100
4223
ACAUCGAUGGACGAGGUGU
4224
AcAUCGAUGGACGAGGUGUdTsdT
antis


 


1082-1101
4225
CACCUCGUCCAUCGAUGUG
4226
cAccucGuccAucGAuGuGdTsdT
sense


 


1082-1101
4227
CACAUCGAUGGACGAGGUG
4228
cAcAUCGAUGGACGAGGUGdTsdT
antis


 


1083-1102
4229
ACCUCGUCCAUCGAUGUGU
4230
AccucGuccAucGAuGuGudTsdT
sense


 


1083-1102
4231
ACACAUCGAUGGACGAGGU
4232
AcAcAUCGAUGGACGAGGUdTsdT
antis


 


1241-1260
4233
CUAUACGGAGUUCAAGUUC
4234
cuAuAcGGAGuucAAGuucdTsdT
sense


 


1241-1260
4235
GAACUUGAACUCCGUAUAG
4236
GAACUUGAACUCCGuAuAGdTsdT
antis


 


1242-1261
4237
UAUACGGAGUUCAAGUUCC
4238
uAuAcGGAGuucAAGuuccdTsdT
sense


 


1242-1261
4239
GGAACUUGAACUCCGUAUA
4240
GGAACUUGAACUCCGuAuAdTsdT
antis


 


1243-1262
4241
AUACGGAGUUCAAGUUCCC
4242
AuAcGGAGuucAAGuucccdTsdT
sense


 


1243-1262
4243
GGGAACUUGAACUCCGUAU
4244
GGGAACUUGAACUCCGuAUdTsdT
antis


 


1396-1415
4245
GCUUCUUCGAUGAACUGCG
4246
GcuucuucGAuGAAcuGcGdTsdT
sense


 


1396-1415
4247
CGCAGUUCAUCGAAGAAGC
4248
CGcAGUUcAUCGAAGAAGCdTsdT
antis


 


1397-1416
4249
CUUCUUCGAUGAACUGCGG
4250
cuucuucGAuGAAcuGcGGdTsdT
sense


 


1397-1416
4251
CCGCAGUUCAUCGAAGAAG
4252
CCGcAGUUcAUCGAAGAAGdTsdT
antis


 


1398-1417
4253
UUCUUCGAUGAACUGCGGA
4254
uucuucGAuGAAcuGcGGAdTsdT
sense


 


1398-1417
4255
UCCGCAGUUCAUCGAAGAA
4256
UCCGcAGUUcAUCGAAGAAdTsdT
antis


 


1400-1419
4257
CUUCGAUGAACUGCGGAGA
4258
cuucGAuGAAcuGcGGAGAdTsdT
sense


 


1400-1419
4259
UCUCCGCAGUUCAUCGAAG
4260
UCUCCGcAGUUcAUCGAAGdTsdT
antis


 


1452-1471
4261
CCCCCCCUGUUCAACUUCA
4262
cccccccuGuucAAcuucAdTsdT
sense


 


1452-1471
4263
UGAAGUUGAACAGGGGGGG
4264
UGAAGUUGAAcAGGGGGGGdTsdT
antis


 


1576-1595
4265
CAUCCUCACAAGCUUUAAC
4266
cAuccucAcAAGcuuuAAcdTsdT
sense


 


1576-1595
4267
GUUAAAGCUUGUGAGGAUG
4268
GUuAAAGCUUGUGAGGAUGdTsdT
antis


 


1634-1653
4269
CACAACUGCUACCCUCGCU
4270
cAcAAcuGcuAcccucGcudTsdT
sense


 


1634-1653
4271
AGCGAGGGUAGCAGUUGUG
4272
AGCGAGGGuAGcAGUUGUGdTsdT
antis


 


1635-1654
4273
ACAACUGCUACCCUCGCUA
4274
AcAAcuGcuAcccucGcuAdTsdT
sense


 


1635-1654
4275
UAGCGAGGGUAGCAGUUGU
4276
uAGCGAGGGuAGcAGUUGUdTsdT
antis


 


1643-1662
4277
UACCCUCGCUAGCUCUUCC
4278
uAcccucGcuAGcucuuccdTsdT
sense


 


1643-1662
4279
GGAAGAGCUAGCGAGGGUA
4280
GGAAGAGCuAGCGAGGGuAdTsdT
antis


 


1645-1664
4281
CCCUCGCUAGCUCUUCCUG
4282
cccucGcuAGcucuuccuGdTsdT
sense


 


1645-1664
4283
CAGGAAGAGCUAGCGAGGG
4284
cAGGAAGAGCuAGCGAGGGdTsdT
antis


 


1660-1679
4285
CCUGAGGGCCCCACCGACU
4286
ccuGAGGGccccAccGAcudTsdT
sense


 


1660-1679
4287
AGUCGGUGGGGCCCUCAGG
4288
AGUCGGUGGGGCCCUcAGGdTsdT
antis


 


1664-1683
4289
AGGGCCCCACCGACUACCC
4290
AGGGccccAccGAcuAcccdTsdT
sense


 


1664-1683
4291
GGGUAGUCGGUGGGGCCCU
4292
GGGuAGUCGGUGGGGCCCUdTsdT
antis


 


1665-1684
4293
GGGCCCCACCGACUACCCC
4294
GGGccccAccGAcuAccccdTsdT
sense


 


1665-1684
4295
GGGGUAGUCGGUGGGGCCC
4296
GGGGuAGUCGGUGGGGCCCdTsdT
antis


 


1816-1835
4297
GCAGCCUAACCUCUGUGGU
4298
GcAGccuAAccucuGuGGudTsdT
sense


 


1816-1835
4299
ACCACAGAGGUUAGGCUGC
4300
ACcAcAGAGGUuAGGCUGCdTsdT
antis


 


1817-1836
4301
CAGCCUAACCUCUGUGGUG
4302
cAGccuAAccucuGuGGuGdTsdT
sense


 


1817-1836
4303
CACCACAGAGGUUAGGCUG
4304
cACcAcAGAGGUuAGGCUGdTsdT
antis


 


1973-1992
4305
CAGGUCCCUUGUAAAUAGA
4306
cAGGucccuuGuAAAuAGAdTsdT
sense


 


1973-1992
4307
UCUAUUUACAAGGGACCUG
4308
UCuAUUuAcAAGGGACCUGdTsdT
antis


 


2206-2225
4309
AAGGUUUGCCUGUGUACAG
4310
AAGGuuuGccuGuGuAcAGdTsdT
sense


 


2206-2225
4311
CUGUACACAGGCAAACCUU
4312
CUGuAcAcAGGcAAACCUUdTsdT
antis


 


2207-2226
4313
AGGUUUGCCUGUGUACAGA
4314
AGGuuuGccuGuGuAcAGAdTsdT
sense


 


2207-2226
4315
UCUGUACACAGGCAAACCU
4316
UCUGuAcAcAGGcAAACCUdTsdT
antis


 


2222-2241
4317
CAGACCUCUGUUCAAUAAA
4318
cAGAccucuGuucAAuAAAdTsdT
sense


 


2222-2241
4319
UUUAUUGAACAGAGGUCUG
4320
UUuAUUGAAcAGAGGUCUGdTsdT
antis


 


542-561
4321
GGCUUACACUGACAUCAAA
4322
GGcuuAcAcuGAcAucAAAdTsdT
sense


 


542-561
4323
UUUGAUGUCAGUGUAAGCC
4324
UUUGAUGUcAGUGuAAGCCdTsdT
antis


 


681-700
4325
AUGCGUAAGCUGGACCACU
4326
AuGcGuAAGcuGGAccAcudTsdT
sense


 


681-700
4327
AGUGGUCCAGCUUACGCAU
4328
AGUGGUCcAGCUuACGcAUdTsdT
antis


 


748-767
4329
AGGACGAGCUGUAUUUGAA
4330
AGGAcGAGcuGuAuuuGAAdTsdT
sense


 


748-767
4331
UUCAAAUACAGCUCGUCCU
4332
UUcAAAuAcAGCUCGUCCUdTsdT
antis


 


749-768
4333
GGACGAGCUGUAUUUGAAU
4334
GGAcGAGcuGuAuuuGAAudTsdT
sense


 


749-768
4335
AUUCAAAUACAGCUCGUCC
4336
AUUcAAAuAcAGCUCGUCCdTsdT
antis


 


1352-1371
4337
CACGCCAUCCUCAAGGCUC
4338
cAcGccAuccucAAGGcucdTsdT
sense


 


1352-1371
4339
GAGCCUUGAGGAUGGCGUG
4340
GAGCCUUGAGGAUGGCGUGdTsdT
antis


 


1944-1963
4341
GCUACCACUCCUUCCCUCC
4342
GcuAccAcuccuucccuccdTsdT
sense


 


1944-1963
4343
GGAGGGAAGGAGUGGUAGC
4344
GGAGGGAAGGAGUGGuAGCdTsdT
antis


 


2004-2023
4345
CAUCUCUCGUCUUCCCUUC
4346
cAucucucGucuucccuucdTsdT
sense


 


2004-2023
4347
GAAGGGAAGACGAGAGAUG
4348
GAAGGGAAGACGAGAGAUGdTsdT
antis


 


348-367
4349
GUCGGGGCUAUGGGUGGGG
4350
GucGGGGcuAuGGGuGGGGdTsdT
sense


 


348-367
4351
CCCCACCCAUAGCCCCGAC
4352
CCCcACCcAuAGCCCCGACdTsdT
antis


 


39-58
4353
CCCGGCGUGCCCCGCGGCG
4354
cccGGcGuGccccGcGGcGdTsdT
sense


 


39-58
4355
CGCCGCGGGGCACGCCGGG
4356
CGCCGCGGGGcACGCCGGGdTsdT
antis


 


184-203
4357
UCGGCGCCAUGAGCGGCGG
4358
ucGGcGccAuGAGcGGcGGdTsdT
sense


 


184-203
4359
CCGCCGCUCAUGGCGCCGA
4360
CCGCCGCUcAUGGCGCCGAdTsdT
antis


 


344-363
4361
GUCAGUCGGGGCUAUGGGU
4362
GucAGucGGGGcuAuGGGudTsdT
sense


 


344-363
4363
ACCCAUAGCCCCGACUGAC
4364
ACCcAuAGCCCCGACUGACdTsdT
antis


 


347-366
4365
AGUCGGGGCUAUGGGUGGG
4366
AGucGGGGcuAuGGGuGGGdTsdT
sense


 


347-366
4367
CCCACCCAUAGCCCCGACU
4368
CCcACCcAuAGCCCCGACUdTsdT
antis


 


454-473
4369
CGCCGGGAGUGAAGCUGGG
4370
cGccGGGAGuGAAGcuGGGdTsdT
sense


 


454-473
4371
CCCAGCUUCACUCCCGGCG
4372
CCcAGCUUcACUCCCGGCGdTsdT
antis


 


456-475
4373
CCGGGAGUGAAGCUGGGCC
4374
ccGGGAGuGAAGcuGGGccdTsdT
sense


 


456-475
4375
GGCCCAGCUUCACUCCCGG
4376
GGCCcAGCUUcACUCCCGGdTsdT
antis


 


477-496
4377
GACAGCGGGAAGGUGACCA
4378
GAcAGcGGGAAGGuGAccAdTsdT
sense


 


477-496
4379
UGGUCACCUUCCCGCUGUC
4380
UGGUcACCUUCCCGCUGUCdTsdT
antis


 


479-498
4381
CAGCGGGAAGGUGACCACA
4382
cAGcGGGAAGGuGAccAcAdTsdT
sense


 


479-498
4383
UGUGGUCACCUUCCCGCUG
4384
UGUGGUcACCUUCCCGCUGdTsdT
antis


 


517-536
4385
AAGGCCCAGAGCGUUCCCA
4386
AAGGcccAGAGcGuucccAdTsdT
sense


 


517-536
4387
UGGGAACGCUCUGGGCCUU
4388
UGGGAACGCUCUGGGCCUUdTsdT
antis


 


518-537
4389
AGGCCCAGAGCGUUCCCAA
4390
AGGcccAGAGcGuucccAAdTsdT
sense


 


518-537
4391
UUGGGAACGCUCUGGGCCU
4392
UUGGGAACGCUCUGGGCCUdTsdT
antis


 


519-538
4393
GGCCCAGAGCGUUCCCAAG
4394
GGcccAGAGcGuucccAAGdTsdT
sense


 


519-538
4395
CUUGGGAACGCUCUGGGCC
4396
CUUGGGAACGCUCUGGGCCdTsdT
antis


 


544-563
4397
CUUACACUGACAUCAAAGU
4398
cuuAcAcuGAcAucAAAGudTsdT
sense


 


544-563
4399
ACUUUGAUGUCAGUGUAAG
4400
ACUUUGAUGUcAGUGuAAGdTsdT
antis


 


545-564
4401
UUACACUGACAUCAAAGUG
4402
uuAcAcuGAcAucAAAGuGdTsdT
sense


 


545-564
4403
CACUUUGAUGUCAGUGUAA
4404
cACUUUGAUGUcAGUGuAAdTsdT
antis


 


603-622
4405
CUGGCAGAGACGAGGGAAC
4406
cuGGcAGAGAcGAGGGAAcdTsdT
sense


 


603-622
4407
GUUCCCUCGUCUCUGCCAG
4408
GUUCCCUCGUCUCUGCcAGdTsdT
antis


 


604-623
4409
UGGCAGAGACGAGGGAACU
4410
uGGcAGAGAcGAGGGAAcudTsdT
sense


 


604-623
4411
AGUUCCCUCGUCUCUGCCA
4412
AGUUCCCUCGUCUCUGCcAdTsdT
antis


 


741-760
4413
GAGAAGAAGGACGAGCUGU
4414
GAGAAGAAGGAcGAGcuGudTsdT
sense


 


741-760
4415
ACAGCUCGUCCUUCUUCUC
4416
AcAGCUCGUCCUUCUUCUCdTsdT
antis


 


752-771
4417
CGAGCUGUAUUUGAAUCUG
4418
cGAGcuGuAuuuGAAucuGdTsdT
sense


 


752-771
4419
CAGAUUCAAAUACAGCUCG
4420
cAGAUUcAAAuAcAGCUCGdTsdT
antis


 


753-772
4421
GAGCUGUAUUUGAAUCUGG
4422
GAGcuGuAuuuGAAucuGGdTsdT
sense


 


753-772
4423
CCAGAUUCAAAUACAGCUC
4424
CcAGAUUcAAAuAcAGCUCdTsdT
antis


 


831-850
4425
CUGAUCACCCCUAUCAUCU
4426
cuGAucAccccuAucAucudTsdT
sense


 


831-850
4427
AGAUGAUAGGGGUGAUCAG
4428
AGAUGAuAGGGGUGAUcAGdTsdT
antis


 


832-851
4429
UGAUCACCCCUAUCAUCUA
4430
uGAucAccccuAucAucuAdTsdT
sense


 


832-851
4431
UAGAUGAUAGGGGUGAUCA
4432
uAGAUGAuAGGGGUGAUcAdTsdT
antis


 


833-852
4433
GAUCACCCCUAUCAUCUAC
4434
GAucAccccuAucAucuAcdTsdT
sense


 


833-852
4435
GUAGAUGAUAGGGGUGAUC
4436
GuAGAUGAuAGGGGUGAUCdTsdT
antis


 


913-932
4437
GUCACCGUGACAUCAAGCC
4438
GucAccGuGAcAucAAGccdTsdT
sense


 


913-932
4439
GGCUUGAUGUCACGGUGAC
4440
GGCUUGAUGUcACGGUGACdTsdT
antis


 


918-937
4441
CGUGACAUCAAGCCCCAGA
4442
cGuGAcAucAAGccccAGAdTsdT
sense


 


918-937
4443
UCUGGGGCUUGAUGUCACG
4444
UCUGGGGCUUGAUGUcACGdTsdT
antis


 


920-939
4445
UGACAUCAAGCCCCAGAAU
4446
uGAcAucAAGccccAGAAudTsdT
sense


 


920-939
4447
AUUCUGGGGCUUGAUGUCA
4448
AUUCUGGGGCUUGAUGUcAdTsdT
antis


 


1018-1037
4449
AUGUGUCCUACAUCUGCUC
4450
AuGuGuccuAcAucuGcucdTsdT
sense


 


1018-1037
4451
GAGCAGAUGUAGGACACAU
4452
GAGcAGAUGuAGGAcAcAUdTsdT
antis


 


1019-1038
4453
UGUGUCCUACAUCUGCUCU
4454
uGuGuccuAcAucuGcucudTsdT
sense


 


1019-1038
4455
AGAGCAGAUGUAGGACACA
4456
AGAGcAGAUGuAGGAcAcAdTsdT
antis


 


1097-1116
4457
UGUGUGGUCGGCUGGCUGU
4458
uGuGuGGucGGcuGGcuGudTsdT
sense


 


1097-1116
4459
ACAGCCAGCCGACCACACA
4460
AcAGCcAGCCGACcAcAcAdTsdT
antis


 


1102-1121
4461
GGUCGGCUGGCUGUGUACU
4462
GGucGGcuGGcuGuGuAcudTsdT
sense


 


1102-1121
4463
AGUACACAGCCAGCCGACC
4464
AGuAcAcAGCcAGCCGACCdTsdT
antis


 


1155-1174
4465
GGGGACAGUGGGGUGGACC
4466
GGGGAcAGuGGGGuGGAccdTsdT
sense


 


1155-1174
4467
GGUCCACCCCACUGUCCCC
4468
GGUCcACCCcACUGUCCCCdTsdT
antis


 


1245-1264
4469
ACGGAGUUCAAGUUCCCCC
4470
AcGGAGuucAAGuucccccdTsdT
sense


 


1245-1264
4471
GGGGGAACUUGAACUCCGU
4472
GGGGGAACUUGAACUCCGUdTsdT
antis


 


1274-1293
4473
UCACCCUUGGACAAAGGUG
4474
ucAcccuuGGAcAAAGGuGdTsdT
sense


 


1274-1293
4475
CACCUUUGUCCAAGGGUGA
4476
cACCUUUGUCcAAGGGUGAdTsdT
antis


 


1276-1295
4477
ACCCUUGGACAAAGGUGUU
4478
AcccuuGGAcAAAGGuGuudTsdT
sense


 


1276-1295
4479
AACACCUUUGUCCAAGGGU
4480
AAcACCUUUGUCcAAGGGUdTsdT
antis


 


1316-1335
4481
UGAGGCCAUUGCACUCUGC
4482
uGAGGccAuuGcAcucuGcdTsdT
sense


 


1316-1335
4483
GCAGAGUGCAAUGGCCUCA
4484
GcAGAGUGcAAUGGCCUcAdTsdT
antis


 


1318-1337
4485
AGGCCAUUGCACUCUGCUC
4486
AGGccAuuGcAcucuGcucdTsdT
sense


 


1318-1337
4487
GAGCAGAGUGCAAUGGCCU
4488
GAGcAGAGUGcAAUGGCCUdTsdT
antis


 


1321-1340
4489
CCAUUGCACUCUGCUCUAG
4490
ccAuuGcAcucuGcucuAGdTsdT
sense


 


1321-1340
4491
CUAGAGCAGAGUGCAAUGG
4492
CuAGAGcAGAGUGcAAUGGdTsdT
antis


 


1325-1344
4493
UGCACUCUGCUCUAGCCUA
4494
uGcAcucuGcucuAGccuAdTsdT
sense


 


1325-1344
4495
UAGGCUAGAGCAGAGUGCA
4496
uAGGCuAGAGcAGAGUGcAdTsdT
antis


 


1337-1356
4497
UAGCCUACUGGAGUACACG
4498
uAGccuAcuGGAGuAcAcGdTsdT
sense


 


1337-1356
4499
CGUGUACUCCAGUAGGCUA
4500
CGUGuACUCcAGuAGGCuAdTsdT
antis


 


1375-1394
4501
CACUCGAGGCUUGUGCCCA
4502
cAcucGAGGcuuGuGcccAdTsdT
sense


 


1375-1394
4503
UGGGCACAAGCCUCGAGUG
4504
UGGGcAcAAGCCUCGAGUGdTsdT
antis


 


1443-1462
4505
CGCCCGCUUCCCCCCCUGU
4506
cGcccGcuucccccccuGudTsdT
sense


 


1443-1462
4507
ACAGGGGGGGAAGCGGGCG
4508
AcAGGGGGGGAAGCGGGCGdTsdT
antis


 


1466-1485
4509
CUUCAGUCCUGGUGAACUG
4510
cuucAGuccuGGuGAAcuGdTsdT
sense


 


1466-1485
4511
CAGUUCACCAGGACUGAAG
4512
cAGUUcACcAGGACUGAAGdTsdT
antis


 


1581-1600
4513
UCACAAGCUUUAACUGAAG
4514
ucAcAAGcuuuAAcuGAAGdTsdT
sense


 


1581-1600
4515
CUUCAGUUAAAGCUUGUGA
4516
CUUcAGUuAAAGCUUGUGAdTsdT
antis


 


1602-1621
4517
CAGACUGGCCAAGAUUGGC
4518
cAGAcuGGccAAGAuuGGcdTsdT
sense


 


1602-1621
4519
GCCAAUCUUGGCCAGUCUG
4520
GCcAAUCUUGGCcAGUCUGdTsdT
antis


 


1603-1622
4521
AGACUGGCCAAGAUUGGCA
4522
AGAcuGGccAAGAuuGGcAdTsdT
sense


 


1603-1622
4523
UGCCAAUCUUGGCCAGUCU
4524
UGCcAAUCUUGGCcAGUCUdTsdT
antis


 


1644-1663
4525
ACCCUCGCUAGCUCUUCCU
4526
AcccucGcuAGcucuuccudTsdT
sense


 


1644-1663
4527
AGGAAGAGCUAGCGAGGGU
4528
AGGAAGAGCuAGCGAGGGUdTsdT
antis


 


1666-1685
4529
GGCCCCACCGACUACCCCU
4530
GGccccAccGAcuAccccudTsdT
sense


 


1666-1685
4531
AGGGGUAGUCGGUGGGGCC
4532
AGGGGuAGUCGGUGGGGCCdTsdT
antis


 


1820-1839
4533
CCUAACCUCUGUGGUGGGC
4534
ccuAAccucuGuGGuGGGcdTsdT
sense


 


1820-1839
4535
GCCCACCACAGAGGUUAGG
4536
GCCcACcAcAGAGGUuAGGdTsdT
antis


 


1821-1840
4537
CUAACCUCUGUGGUGGGCU
4538
cuAAccucuGuGGuGGGcudTsdT
sense


 


1821-1840
4539
AGCCCACCACAGAGGUUAG
4540
AGCCcACcAcAGAGGUuAGdTsdT
antis


 


1855-1874
4541
UAACUGUUUGUAGGGGAGG
4542
uAAcuGuuuGuAGGGGAGGdTsdT
sense


 


1855-1874
4543
CCUCCCCUACAAACAGUUA
4544
CCUCCCCuAcAAAcAGUuAdTsdT
antis


 


1861-1880
4545
UUUGUAGGGGAGGGGAGAA
4546
uuuGuAGGGGAGGGGAGAAdTsdT
sense


 


1861-1880
4547
UUCUCCCCUCCCCUACAAA
4548
UUCUCCCCUCCCCuAcAAAdTsdT
antis


 


1912-1931
4549
UUCUACCCCCUUGGUCCCC
4550
uucuAcccccuuGGuccccdTsdT
sense


 


1912-1931
4551
GGGGACCAAGGGGGUAGAA
4552
GGGGACcAAGGGGGuAGAAdTsdT
antis


 


1960-1979
4553
UCCCCCCCUCUCCCAGGUC
4554
ucccccccucucccAGGucdTsdT
sense


 


1960-1979
4555
GACCUGGGAGAGGGGGGGA
4556
GACCUGGGAGAGGGGGGGAdTsdT
antis


 


2009-2028
4557
CUCGUCUUCCCUUCCCUGG
4558
cucGucuucccuucccuGGdTsdT
sense


 


2009-2028
4559
CCAGGGAAGGGAAGACGAG
4560
CcAGGGAAGGGAAGACGAGdTsdT
antis


 


2010-2029
4561
UCGUCUUCCCUUCCCUGGC
4562
ucGucuucccuucccuGGcdTsdT
sense


 


2010-2029
4563
GCCAGGGAAGGGAAGACGA
4564
GCcAGGGAAGGGAAGACGAdTsdT
antis


 


2011-2030
4565
CGUCUUCCCUUCCCUGGCC
4566
cGucuucccuucccuGGccdTsdT
sense


 


2011-2030
4567
GGCCAGGGAAGGGAAGACG
4568
GGCcAGGGAAGGGAAGACGdTsdT
antis


 


2223-2242
4569
AGACCUCUGUUCAAUAAAU
4570
AGAccucuGuucAAuAAAudTsdT
sense


 


2223-2242
4571
AUUUAUUGAACAGAGGUCU
4572
AUUuAUUGAAcAGAGGUCUdTsdT
antis


 


2226-2245
4573
CCUCUGUUCAAUAAAUUAU
4574
ccucuGuucAAuAAAuuAudTsdT
sense


 


2226-2245
4575
AUAAUUUAUUGAACAGAGG
4576
AuAAUUuAUUGAAcAGAGGdTsdT
antis


 


2228-2247
4577
UCUGUUCAAUAAAUUAUUG
4578
ucuGuucAAuAAAuuAuuGdTsdT
sense


 


2228-2247
4579
CAAUAAUUUAUUGAACAGA
4580
cAAuAAUUuAUUGAAcAGAdTsdT
antis


 


 9-28
4581
AACGAAGCCGACGGCAGAG
4582
AAcGAAGccGAcGGcAGAGdTsdT
sense


 


 9-28
4583
CUCUGCCGUCGGCUUCGUU
4584
CUCUGCCGUCGGCUUCGUUdTsdT
antis


 


10-29
4585
ACGAAGCCGACGGCAGAGG
4586
AcGAAGccGAcGGcAGAGGdTsdT
sense


 


10-29
4587
CCUCUGCCGUCGGCUUCGU
4588
CCUCUGCCGUCGGCUUCGUdTsdT
antis


 


20-39
4589
CGGCAGAGGGACUUCAUCU
4590
cGGcAGAGGGAcuucAucudTsdT
sense


 


20-39
4591
AGAUGAAGUCCCUCUGCCG
4592
AGAUGAAGUCCCUCUGCCGdTsdT
antis


 


26-45
4593
AGGGACUUCAUCUCCCGGC
4594
AGGGAcuucAucucccGGcdTsdT
sense


 


26-45
4595
GCCGGGAGAUGAAGUCCCU
4596
GCCGGGAGAUGAAGUCCCUdTsdT
antis


 


27-46
4597
GGGACUUCAUCUCCCGGCG
4598
GGGAcuucAucucccGGcGdTsdT
sense


 


27-46
4599
CGCCGGGAGAUGAAGUCCC
4600
CGCCGGGAGAUGAAGUCCCdTsdT
antis


 


28-47
4601
GGACUUCAUCUCCCGGCGU
4602
GGAcuucAucucccGGcGudTsdT
sense


 


28-47
4603
ACGCCGGGAGAUGAAGUCC
4604
ACGCCGGGAGAUGAAGUCCdTsdT
antis


 


29-48
4605
GACUUCAUCUCCCGGCGUG
4606
GAcuucAucucccGGcGuGdTsdT
sense


 


29-48
4607
CACGCCGGGAGAUGAAGUC
4608
cACGCCGGGAGAUGAAGUCdTsdT
antis


 


37-56
4609
CUCCCGGCGUGCCCCGCGG
4610
cucccGGcGuGccccGcGGdTsdT
sense


 


37-56
4611
CCGCGGGGCACGCCGGGAG
4612
CCGCGGGGcACGCCGGGAGdTsdT
antis


 


38-57
4613
UCCCGGCGUGCCCCGCGGC
4614
ucccGGcGuGccccGcGGcdTsdT
sense


 


38-57
4615
GCCGCGGGGCACGCCGGGA
4616
GCCGCGGGGcACGCCGGGAdTsdT
antis


 


42-61
4617
GGCGUGCCCCGCGGCGGGC
4618
GGcGuGccccGcGGcGGGcdTsdT
sense


 


42-61
4619
GCCCGCCGCGGGGCACGCC
4620
GCCCGCCGCGGGGcACGCCdTsdT
antis


 


43-62
4621
GCGUGCCCCGCGGCGGGCG
4622
GcGuGccccGcGGcGGGcGdTsdT
sense


 


43-62
4623
CGCCCGCCGCGGGGCACGC
4624
CGCCCGCCGCGGGGcACGCdTsdT
antis


 


59-78
4625
GCGCUGGGCCGGAGCCGGA
4626
GcGcuGGGccGGAGccGGAdTsdT
sense


 


59-78
4627
UCCGGCUCCGGCCCAGCGC
4628
UCCGGCUCCGGCCcAGCGCdTsdT
antis


 


60-79
4629
CGCUGGGCCGGAGCCGGAG
4630
cGcuGGGccGGAGccGGAGdTsdT
sense


 


60-79
4631
CUCCGGCUCCGGCCCAGCG
4632
CUCCGGCUCCGGCCcAGCGdTsdT
antis


 


 99-118
4633
AGAGGCCGGAGCCCAGGGG
4634
AGAGGccGGAGcccAGGGGdTsdT
sense


 


 99-118
4635
CCCCUGGGCUCCGGCCUCU
4636
CCCCUGGGCUCCGGCCUCUdTsdT
antis


 


108-127
4637
AGCCCAGGGGAGGCGGCGG
4638
AGcccAGGGGAGGcGGcGGdTsdT
sense


 


108-127
4639
CCGCCGCCUCCCCUGGGCU
4640
CCGCCGCCUCCCCUGGGCUdTsdT
antis


 


109-128
4641
GCCCAGGGGAGGCGGCGGC
4642
GcccAGGGGAGGcGGcGGcdTsdT
sense


 


109-128
4643
GCCGCCGCCUCCCCUGGGC
4644
GCCGCCGCCUCCCCUGGGCdTsdT
antis


 


133-152
4645
CAGCGGCGGGGGCAGCCCA
4646
cAGcGGcGGGGGcAGcccAdTsdT
sense


 


133-152
4647
UGGGCUGCCCCCGCCGCUG
4648
UGGGCUGCCCCCGCCGCUGdTsdT
antis


 


135-154
4649
GCGGCGGGGGCAGCCCAGG
4650
GcGGcGGGGGcAGcccAGGdTsdT
sense


 


135-154
4651
CCUGGGCUGCCCCCGCCGC
4652
CCUGGGCUGCCCCCGCCGCdTsdT
antis


 


136-155
4653
CGGCGGGGGCAGCCCAGGC
4654
cGGcGGGGGcAGcccAGGcdTsdT
sense


 


136-155
4655
GCCUGGGCUGCCCCCGCCG
4656
GCCUGGGCUGCCCCCGCCGdTsdT
antis


 


140-159
4657
GGGGGCAGCCCAGGCAGCC
4658
GGGGGcAGcccAGGcAGccdTsdT
sense


 


140-159
4659
GGCUGCCUGGGCUGCCCCC
4660
GGCUGCCUGGGCUGCCCCCdTsdT
antis


 


165-184
4661
CCGCGGCCUGGGCCUGCGC
4662
ccGcGGccuGGGccuGcGcdTsdT
sense


 


165-184
4663
GCGCAGGCCCAGGCCGCGG
4664
GCGcAGGCCcAGGCCGCGGdTsdT
antis


 


170-189
4665
GCCUGGGCCUGCGCUCGGC
4666
GccuGGGccuGcGcucGGcdTsdT
sense


 


170-189
4667
GCCGAGCGCAGGCCCAGGC
4668
GCCGAGCGcAGGCCcAGGCdTsdT
antis


 


171-190
4669
CCUGGGCCUGCGCUCGGCG
4670
ccuGGGccuGcGcucGGcGdTsdT
sense


 


171-190
4671
CGCCGAGCGCAGGCCCAGG
4672
CGCCGAGCGcAGGCCcAGGdTsdT
antis


 


185-204
4673
CGGCGCCAUGAGCGGCGGC
4674
cGGcGccAuGAGcGGcGGcdTsdT
sense


 


185-204
4675
GCCGCCGCUCAUGGCGCCG
4676
GCCGCCGCUcAUGGCGCCGdTsdT
antis


 


201-220
4677
GGCGGGCCUUCGGGAGGCG
4678
GGcGGGccuucGGGAGGcGdTsdT
sense


 


201-220
4679
CGCCUCCCGAAGGCCCGCC
4680
CGCCUCCCGAAGGCCCGCCdTsdT
antis


 


214-233
4681
GAGGCGGCCCUGGGGGCUC
4682
GAGGcGGcccuGGGGGcucdTsdT
sense


 


214-233
4683
GAGCCCCCAGGGCCGCCUC
4684
GAGCCCCcAGGGCCGCCUCdTsdT
antis


 


215-234
4685
AGGCGGCCCUGGGGGCUCG
4686
AGGcGGcccuGGGGGcucGdTsdT
sense


 


215-234
4687
CGAGCCCCCAGGGCCGCCU
4688
CGAGCCCCcAGGGCCGCCUdTsdT
antis


 


216-235
4689
GGCGGCCCUGGGGGCUCGG
4690
GGcGGcccuGGGGGcucGGdTsdT
sense


 


216-235
4691
CCGAGCCCCCAGGGCCGCC
4692
CCGAGCCCCcAGGGCCGCCdTsdT
antis


 


227-246
4693
GGGCUCGGGCCGGGCGCGG
4694
GGGcucGGGccGGGcGcGGdTsdT
sense


 


227-246
4695
CCGCGCCCGGCCCGAGCCC
4696
CCGCGCCCGGCCCGAGCCCdTsdT
antis


 


229-248
4697
GCUCGGGCCGGGCGCGGAC
4698
GcucGGGccGGGcGcGGAcdTsdT
sense


 


229-248
4699
GUCCGCGCCCGGCCCGAGC
4700
GUCCGCGCCCGGCCCGAGCdTsdT
antis


 


230-249
4701
CUCGGGCCGGGCGCGGACC
4702
cucGGGccGGGcGcGGAccdTsdT
sense


 


230-249
4703
GGUCCGCGCCCGGCCCGAG
4704
GGUCCGCGCCCGGCCCGAGdTsdT
antis


 


290-309
4705
CGGCGGCCCCGGGGGCUCG
4706
cGGcGGccccGGGGGcucGdTsdT
sense


 


290-309
4707
CGAGCCCCCGGGGCCGCCG
4708
CGAGCCCCCGGGGCCGCCGdTsdT
antis


 


292-311
4709
GCGGCCCCGGGGGCUCGGC
4710
GcGGccccGGGGGcucGGcdTsdT
sense


 


292-311
4711
GCCGAGCCCCCGGGGCCGC
4712
GCCGAGCCCCCGGGGCCGCdTsdT
antis


 


293-312
4713
CGGCCCCGGGGGCUCGGCC
4714
cGGccccGGGGGcucGGccdTsdT
sense


 


293-312
4715
GGCCGAGCCCCCGGGGCCG
4716
GGCCGAGCCCCCGGGGCCGdTsdT
antis


 


299-318
4717
CGGGGGCUCGGCCUCUGGC
4718
cGGGGGcucGGccucuGGcdTsdT
sense


 


299-318
4719
GCCAGAGGCCGAGCCCCCG
4720
GCcAGAGGCCGAGCCCCCGdTsdT
antis


 


300-319
4721
GGGGGCUCGGCCUCUGGCC
4722
GGGGGcucGGccucuGGccdTsdT
sense


 


300-319
4723
GGCCAGAGGCCGAGCCCCC
4724
GGCcAGAGGCCGAGCCCCCdTsdT
antis


 


302-321
4725
GGGCUCGGCCUCUGGCCCA
4726
GGGcucGGccucuGGcccAdTsdT
sense


 


302-321
4727
UGGGCCAGAGGCCGAGCCC
4728
UGGGCcAGAGGCCGAGCCCdTsdT
antis


 


304-323
4729
GCUCGGCCUCUGGCCCAGG
4730
GcucGGccucuGGcccAGGdTsdT
sense


 


304-323
4731
CCUGGGCCAGAGGCCGAGC
4732
CCUGGGCcAGAGGCCGAGCdTsdT
antis


 


305-324
4733
CUCGGCCUCUGGCCCAGGA
4734
cucGGccucuGGcccAGGAdTsdT
sense


 


305-324
4735
UCCUGGGCCAGAGGCCGAG
4736
UCCUGGGCcAGAGGCCGAGdTsdT
antis


 


306-325
4737
UCGGCCUCUGGCCCAGGAG
4738
ucGGccucuGGcccAGGAGdTsdT
sense


 


306-325
4739
CUCCUGGGCCAGAGGCCGA
4740
CUCCUGGGCcAGAGGCCGAdTsdT
antis


 


307-326
4741
CGGCCUCUGGCCCAGGAGG
4742
cGGccucuGGcccAGGAGGdTsdT
sense


 


307-326
4743
CCUCCUGGGCCAGAGGCCG
4744
CCUCCUGGGCcAGAGGCCGdTsdT
antis


 


322-341
4745
GAGGCACUGGCGGCGGGAA
4746
GAGGcAcuGGcGGcGGGAAdTsdT
sense


 


322-341
4747
UUCCCGCCGCCAGUGCCUC
4748
UUCCCGCCGCcAGUGCCUCdTsdT
antis


 


339-358
4749
AAAGCGUCAGUCGGGGCUA
4750
AAAGcGucAGucGGGGcuAdTsdT
sense


 


339-358
4751
UAGCCCCGACUGACGCUUU
4752
uAGCCCCGACUGACGCUUUdTsdT
antis


 


345-364
4753
UCAGUCGGGGCUAUGGGUG
4754
ucAGucGGGGcuAuGGGuGdTsdT
sense


 


345-364
4755
CACCCAUAGCCCCGACUGA
4756
cACCcAuAGCCCCGACUGAdTsdT
antis


 


346-365
4757
CAGUCGGGGCUAUGGGUGG
4758
cAGucGGGGcuAuGGGuGGdTsdT
sense


 


346-365
4759
CCACCCAUAGCCCCGACUG
4760
CcACCcAuAGCCCCGACUGdTsdT
antis


 


350-369
4761
CGGGGCUAUGGGUGGGGGC
4762
cGGGGcuAuGGGuGGGGGcdTsdT
sense


 


350-369
4763
GCCCCCACCCAUAGCCCCG
4764
GCCCCcACCcAuAGCCCCGdTsdT
antis


 


374-393
4765
AGCCUCGAGCUCCGGGGGU
4766
AGccucGAGcuccGGGGGudTsdT
sense


 


374-393
4767
ACCCCCGGAGCUCGAGGCU
4768
ACCCCCGGAGCUCGAGGCUdTsdT
antis


 


378-397
4769
UCGAGCUCCGGGGGUGGCC
4770
ucGAGcuccGGGGGuGGccdTsdT
sense


 


378-397
4771
GGCCACCCCCGGAGCUCGA
4772
GGCcACCCCCGGAGCUCGAdTsdT
antis


 


379-398
4773
CGAGCUCCGGGGGUGGCCC
4774
cGAGcuccGGGGGuGGcccdTsdT
sense


 


379-398
4775
GGGCCACCCCCGGAGCUCG
4776
GGGCcACCCCCGGAGCUCGdTsdT
antis


 


384-403
4777
UCCGGGGGUGGCCCCAGCG
4778
uccGGGGGuGGccccAGcGdTsdT
sense


 


384-403
4779
CGCUGGGGCCACCCCCGGA
4780
CGCUGGGGCcACCCCCGGAdTsdT
antis


 


394-413
4781
GCCCCAGCGGCAGCGGCGG
4782
GccccAGcGGcAGcGGcGGdTsdT
sense


 


394-413
4783
CCGCCGCUGCCGCUGGGGC
4784
CCGCCGCUGCCGCUGGGGCdTsdT
antis


 


418-437
4785
GCAGCGGUGGCCCCGGCGC
4786
GcAGcGGuGGccccGGcGcdTsdT
sense


 


418-437
4787
GCGCCGGGGCCACCGCUGC
4788
GCGCCGGGGCcACCGCUGCdTsdT
antis


 


419-438
4789
CAGCGGUGGCCCCGGCGCG
4790
cAGcGGuGGccccGGcGcGdTsdT
sense


 


419-438
4791
CGCGCCGGGGCCACCGCUG
4792
CGCGCCGGGGCcACCGCUGdTsdT
antis


 


421-440
4793
GCGGUGGCCCCGGCGCGGG
4794
GcGGuGGccccGGcGcGGGdTsdT
sense


 


421-440
4795
CCCGCGCCGGGGCCACCGC
4796
CCCGCGCCGGGGCcACCGCdTsdT
antis


 


422-441
4797
CGGUGGCCCCGGCGCGGGC
4798
cGGuGGccccGGcGcGGGcdTsdT
sense


 


422-441
4799
GCCCGCGCCGGGGCCACCG
4800
GCCCGCGCCGGGGCcACCGdTsdT
antis


 


423-442
4801
GGUGGCCCCGGCGCGGGCA
4802
GGuGGccccGGcGcGGGcAdTsdT
sense


 


423-442
4803
UGCCCGCGCCGGGGCCACC
4804
UGCCCGCGCCGGGGCcACCdTsdT
antis


 


424-443
4805
GUGGCCCCGGCGCGGGCAC
4806
GuGGccccGGcGcGGGcAcdTsdT
sense


 


424-443
4807
GUGCCCGCGCCGGGGCCAC
4808
GUGCCCGCGCCGGGGCcACdTsdT
antis


 


443-462
4809
UAGCUUCCCGCCGCCGGGA
4810
uAGcuucccGccGccGGGAdTsdT
sense


 


443-462
4811
UCCCGGCGGCGGGAAGCUA
4812
UCCCGGCGGCGGGAAGCuAdTsdT
antis


 


450-469
4813
CCGCCGCCGGGAGUGAAGC
4814
ccGccGccGGGAGuGAAGcdTsdT
sense


 


450-469
4815
GCUUCACUCCCGGCGGCGG
4816
GCUUcACUCCCGGCGGCGGdTsdT
antis


 


455-474
4817
GCCGGGAGUGAAGCUGGGC
4818
GccGGGAGuGAAGcuGGGcdTsdT
sense


 


455-474
4819
GCCCAGCUUCACUCCCGGC
4820
GCCcAGCUUcACUCCCGGCdTsdT
antis


 


457-476
4821
CGGGAGUGAAGCUGGGCCG
4822
cGGGAGuGAAGcuGGGccGdTsdT
sense


 


457-476
4823
CGGCCCAGCUUCACUCCCG
4824
CGGCCcAGCUUcACUCCCGdTsdT
antis


 


462-481
4825
GUGAAGCUGGGCCGUGACA
4826
GuGAAGcuGGGccGuGAcAdTsdT
sense


 


462-481
4827
UGUCACGGCCCAGCUUCAC
4828
UGUcACGGCCcAGCUUcACdTsdT
antis


 


467-486
4829
GCUGGGCCGUGACAGCGGG
4830
GcuGGGccGuGAcAGcGGGdTsdT
sense


 


467-486
4831
CCCGCUGUCACGGCCCAGC
4832
CCCGCUGUcACGGCCcAGCdTsdT
antis


 


478-497
4833
ACAGCGGGAAGGUGACCAC
4834
AcAGcGGGAAGGuGAccAcdTsdT
sense


 


478-497
4835
GUGGUCACCUUCCCGCUGU
4836
GUGGUcACCUUCCCGCUGUdTsdT
antis


 


482-501
4837
CGGGAAGGUGACCACAGUG
4838
cGGGAAGGuGAccAcAGuGdTsdT
sense


 


482-501
4839
CACUGUGGUCACCUUCCCG
4840
cACUGUGGUcACCUUCCCGdTsdT
antis


 


498-517
4841
GUGGUAGCCACUGUAGGCC
4842
GuGGuAGccAcuGuAGGccdTsdT
sense


 


498-517
4843
GGCCUACAGUGGCUACCAC
4844
GGCCuAcAGUGGCuACcACdTsdT
antis


 


499-518
4845
UGGUAGCCACUGUAGGCCA
4846
uGGuAGccAcuGuAGGccAdTsdT
sense


 


499-518
4847
UGGCCUACAGUGGCUACCA
4848
UGGCCuAcAGUGGCuACcAdTsdT
antis


 


500-519
4849
GGUAGCCACUGUAGGCCAA
4850
GGuAGccAcuGuAGGccAAdTsdT
sense


 


500-519
4851
UUGGCCUACAGUGGCUACC
4852
UUGGCCuAcAGUGGCuACCdTsdT
antis


 


501-520
4853
GUAGCCACUGUAGGCCAAG
4854
GuAGccAcuGuAGGccAAGdTsdT
sense


 


501-520
4855
CUUGGCCUACAGUGGCUAC
4856
CUUGGCCuAcAGUGGCuACdTsdT
antis


 


508-527
4857
CUGUAGGCCAAGGCCCAGA
4858
cuGuAGGccAAGGcccAGAdTsdT
sense


 


508-527
4859
UCUGGGCCUUGGCCUACAG
4860
UCUGGGCCUUGGCCuAcAGdTsdT
antis


 


514-533
4861
GCCAAGGCCCAGAGCGUUC
4862
GccAAGGcccAGAGcGuucdTsdT
sense


 


514-533
4863
GAACGCUCUGGGCCUUGGC
4864
GAACGCUCUGGGCCUUGGCdTsdT
antis


 


515-534
4865
CCAAGGCCCAGAGCGUUCC
4866
ccAAGGcccAGAGcGuuccdTsdT
sense


 


515-534
4867
GGAACGCUCUGGGCCUUGG
4868
GGAACGCUCUGGGCCUUGGdTsdT
antis


 


540-559
4869
GUGGCUUACACUGACAUCA
4870
GuGGcuuAcAcuGAcAucAdTsdT
sense


 


540-559
4871
UGAUGUCAGUGUAAGCCAC
4872
UGAUGUcAGUGuAAGCcACdTsdT
antis


 


541-560
4873
UGGCUUACACUGACAUCAA
4874
uGGcuuAcAcuGAcAucAAdTsdT
sense


 


541-560
4875
UUGAUGUCAGUGUAAGCCA
4876
UUGAUGUcAGUGuAAGCcAdTsdT
antis


 


543-562
4877
GCUUACACUGACAUCAAAG
4878
GcuuAcAcuGAcAucAAAGdTsdT
sense


 


543-562
4879
CUUUGAUGUCAGUGUAAGC
4880
CUUUGAUGUcAGUGuAAGCdTsdT
antis


 


546-565
4881
UACACUGACAUCAAAGUGA
4882
uAcAcuGAcAucAAAGuGAdTsdT
sense


 


546-565
4883
UCACUUUGAUGUCAGUGUA
4884
UcACUUUGAUGUcAGUGuAdTsdT
antis


 


594-613
4885
CAGGCACGGCUGGCAGAGA
4886
cAGGcAcGGcuGGcAGAGAdTsdT
sense


 


594-613
4887
UCUCUGCCAGCCGUGCCUG
4888
UCUCUGCcAGCCGUGCCUGdTsdT
antis


 


605-624
4889
GGCAGAGACGAGGGAACUG
4890
GGcAGAGAcGAGGGAAcuGdTsdT
sense


 


605-624
4891
CAGUUCCCUCGUCUCUGCC
4892
cAGUUCCCUCGUCUCUGCCdTsdT
antis


 


607-626
4893
CAGAGACGAGGGAACUGGU
4894
cAGAGAcGAGGGAAcuGGudTsdT
sense


 


607-626
4895
ACCAGUUCCCUCGUCUCUG
4896
ACcAGUUCCCUCGUCUCUGdTsdT
antis


 


617-636
4897
GGAACUGGUGGCCAUCAAG
4898
GGAAcuGGuGGccAucAAGdTsdT
sense


 


617-636
4899
CUUGAUGGCCACCAGUUCC
4900
CUUGAUGGCcACcAGUUCCdTsdT
antis


 


618-637
4901
GAACUGGUGGCCAUCAAGA
4902
GAAcuGGuGGccAucAAGAdTsdT
sense


 


618-637
4903
UCUUGAUGGCCACCAGUUC
4904
UCUUGAUGGCcACcAGUUCdTsdT
antis


 


619-638
4905
AACUGGUGGCCAUCAAGAA
4906
AAcuGGuGGccAucAAGAAdTsdT
sense


 


619-638
4907
UUCUUGAUGGCCACCAGUU
4908
UUCUUGAUGGCcACcAGUUdTsdT
antis


 


624-643
4909
GUGGCCAUCAAGAAGGUUC
4910
GuGGccAucAAGAAGGuucdTsdT
sense


 


624-643
4911
GAACCUUCUUGAUGGCCAC
4912
GAACCUUCUUGAUGGCcACdTsdT
antis


 


625-644
4913
UGGCCAUCAAGAAGGUUCU
4914
uGGccAucAAGAAGGuucudTsdT
sense


 


625-644
4915
AGAACCUUCUUGAUGGCCA
4916
AGAACCUUCUUGAUGGCcAdTsdT
antis


 


647-666
4917
GGACAAAAGGUUCAAGAAC
4918
GGAcAAAAGGuucAAGAAcdTsdT
sense


 


647-666
4919
GUUCUUGAACCUUUUGUCC
4920
GUUCUUGAACCUUUUGUCCdTsdT
antis


 


648-667
4921
GACAAAAGGUUCAAGAACC
4922
GAcAAAAGGuucAAGAAccdTsdT
sense


 


648-667
4923
GGUUCUUGAACCUUUUGUC
4924
GGUUCUUGAACCUUUUGUCdTsdT
antis


 


666-685
4925
CGAGAACUGCAGAUUAUGC
4926
cGAGAAcuGcAGAuuAuGcdTsdT
sense


 


666-685
4927
GCAUAAUCUGCAGUUCUCG
4928
GcAuAAUCUGcAGUUCUCGdTsdT
antis


 


713-732
4929
GCUGCGGUACUUUUUCUAC
4930
GcuGcGGuAcuuuuucuAcdTsdT
sense


 


713-732
4931
GUAGAAAAAGUACCGCAGC
4932
GuAGAAAAAGuACCGcAGCdTsdT
antis


 


717-736
4933
CGGUACUUUUUCUACUCCA
4934
cGGuAcuuuuucuAcuccAdTsdT
sense


 


717-736
4935
UGGAGUAGAAAAAGUACCG
4936
UGGAGuAGAAAAAGuACCGdTsdT
antis


 


739-758
4937
GGGAGAAGAAGGACGAGCU
4938
GGGAGAAGAAGGAcGAGcudTsdT
sense


 


739-758
4939
AGCUCGUCCUUCUUCUCCC
4940
AGCUCGUCCUUCUUCUCCCdTsdT
antis


 


740-759
4941
GGAGAAGAAGGACGAGCUG
4942
GGAGAAGAAGGAcGAGcuGdTsdT
sense


 


740-759
4943
CAGCUCGUCCUUCUUCUCC
4944
cAGCUCGUCCUUCUUCUCCdTsdT
antis


 


794-813
4945
GGUGUACCGAGUGGCCCGC
4946
GGuGuAccGAGuGGcccGcdTsdT
sense


 


794-813
4947
GCGGGCCACUCGGUACACC
4948
GCGGGCcACUCGGuAcACCdTsdT
antis


 


798-817
4949
UACCGAGUGGCCCGCCACU
4950
uAccGAGuGGcccGccAcudTsdT
sense


 


798-817
4951
AGUGGCGGGCCACUCGGUA
4952
AGUGGCGGGCcACUCGGuAdTsdT
antis


 


822-841
4953
AAGGCCAAGCUGAUCACCC
4954
AAGGccAAGcuGAucAcccdTsdT
sense


 


822-841
4955
GGGUGAUCAGCUUGGCCUU
4956
GGGUGAUcAGCUUGGCCUUdTsdT
antis


 


823-842
4957
AGGCCAAGCUGAUCACCCC
4958
AGGccAAGcuGAucAccccdTsdT
sense


 


823-842
4959
GGGGUGAUCAGCUUGGCCU
4960
GGGGUGAUcAGCUUGGCCUdTsdT
antis


 


846-865
4961
AUCUACAUCAAGGUGUACA
4962
AucuAcAucAAGGuGuAcAdTsdT
sense


 


846-865
4963
UGUACACCUUGAUGUAGAU
4964
UGuAcACCUUGAUGuAGAUdTsdT
antis


 


847-866
4965
UCUACAUCAAGGUGUACAU
4966
ucuAcAucAAGGuGuAcAudTsdT
sense


 


847-866
4967
AUGUACACCUUGAUGUAGA
4968
AUGuAcACCUUGAUGuAGAdTsdT
antis


 


848-867
4969
CUACAUCAAGGUGUACAUG
4970
cuAcAucAAGGuGuAcAuGdTsdT
sense


 


848-867
4971
CAUGUACACCUUGAUGUAG
4972
cAUGuAcACCUUGAUGuAGdTsdT
antis


 


849-868
4973
UACAUCAAGGUGUACAUGU
4974
uAcAucAAGGuGuAcAuGudTsdT
sense


 


849-868
4975
ACAUGUACACCUUGAUGUA
4976
AcAUGuAcACCUUGAUGuAdTsdT
antis


 


889-908
4977
CCUACAUCCACUCCCAAGG
4978
ccuAcAuccAcucccAAGGdTsdT
sense


 


889-908
4979
CCUUGGGAGUGGAUGUAGG
4980
CCUUGGGAGUGGAUGuAGGdTsdT
antis


 


892-911
4981
ACAUCCACUCCCAAGGUGU
4982
AcAuccAcucccAAGGuGudTsdT
sense


 


892-911
4983
ACACCUUGGGAGUGGAUGU
4984
AcACCUUGGGAGUGGAUGUdTsdT
antis


 


893-912
4985
CAUCCACUCCCAAGGUGUG
4986
cAuccAcucccAAGGuGuGdTsdT
sense


 


893-912
4987
CACACCUUGGGAGUGGAUG
4988
cAcACCUUGGGAGUGGAUGdTsdT
antis


 


904-923
4989
AAGGUGUGUGUCACCGUGA
4990
AAGGuGuGuGucAccGuGAdTsdT
sense


 


904-923
4991
UCACGGUGACACACACCUU
4992
UcACGGUGAcAcAcACCUUdTsdT
antis


 


905-924
4993
AGGUGUGUGUCACCGUGAC
4994
AGGuGuGuGucAccGuGAcdTsdT
sense


 


905-924
4995
GUCACGGUGACACACACCU
4996
GUcACGGUGAcAcAcACCUdTsdT
antis


 


906-925
4997
GGUGUGUGUCACCGUGACA
4998
GGuGuGuGucAccGuGAcAdTsdT
sense


 


906-925
4999
UGUCACGGUGACACACACC
5000
UGUcACGGUGAcAcAcACCdTsdT
antis


 


907-926
5001
GUGUGUGUCACCGUGACAU
5002
GuGuGuGucAccGuGAcAudTsdT
sense


 


907-926
5003
AUGUCACGGUGACACACAC
5004
AUGUcACGGUGAcAcAcACdTsdT
antis


 


908-927
5005
UGUGUGUCACCGUGACAUC
5006
uGuGuGucAccGuGAcAucdTsdT
sense


 


908-927
5007
GAUGUCACGGUGACACACA
5008
GAUGUcACGGUGAcAcAcAdTsdT
antis


 


909-928
5009
GUGUGUCACCGUGACAUCA
5010
GuGuGucAccGuGAcAucAdTsdT
sense


 


909-928
5011
UGAUGUCACGGUGACACAC
5012
UGAUGUcACGGUGAcAcACdTsdT
antis


 


910-929
5013
UGUGUCACCGUGACAUCAA
5014
uGuGucAccGuGAcAucAAdTsdT
sense


 


910-929
5015
UUGAUGUCACGGUGACACA
5016
UUGAUGUcACGGUGAcAcAdTsdT
antis


 


919-938
5017
GUGACAUCAAGCCCCAGAA
5018
GuGAcAucAAGccccAGAAdTsdT
sense


 


919-938
5019
UUCUGGGGCUUGAUGUCAC
5020
UUCUGGGGCUUGAUGUcACdTsdT
antis


 


946-965
5021
UGGACCCUGACACUGCUGU
5022
uGGAcccuGAcAcuGcuGudTsdT
sense


 


946-965
5023
ACAGCAGUGUCAGGGUCCA
5024
AcAGcAGUGUcAGGGUCcAdTsdT
antis


 


950-969
5025
CCCUGACACUGCUGUCCUC
5026
cccuGAcAcuGcuGuccucdTsdT
sense


 


950-969
5027
GAGGACAGCAGUGUCAGGG
5028
GAGGAcAGcAGUGUcAGGGdTsdT
antis


 


957-976
5029
ACUGCUGUCCUCAAGCUCU
5030
AcuGcuGuccucAAGcucudTsdT
sense


 


957-976
5031
AGAGCUUGAGGACAGCAGU
5032
AGAGCUUGAGGAcAGcAGUdTsdT
antis


 


961-980
5033
CUGUCCUCAAGCUCUGCGA
5034
cuGuccucAAGcucuGcGAdTsdT
sense


 


961-980
5035
UCGCAGAGCUUGAGGACAG
5036
UCGcAGAGCUUGAGGAcAGdTsdT
antis


 


962-981
5037
UGUCCUCAAGCUCUGCGAU
5038
uGuccucAAGcucuGcGAudTsdT
sense


 


962-981
5039
AUCGCAGAGCUUGAGGACA
5040
AUCGcAGAGCUUGAGGAcAdTsdT
antis


 


1020-1039
5041
GUGUCCUACAUCUGCUCUC
5042
GuGuccuAcAucuGcucucdTsdT
sense


 


1020-1039
5043
GAGAGCAGAUGUAGGACAC
5044
GAGAGcAGAUGuAGGAcACdTsdT
antis


 


1029-1048
5045
AUCUGCUCUCGGUACUACC
5046
AucuGcucucGGuAcuAccdTsdT
sense


 


1029-1048
5047
GGUAGUACCGAGAGCAGAU
5048
GGuAGuACCGAGAGcAGAUdTsdT
antis


 


1048-1067
5049
GUGCUCCAGAACUCAUCUU
5050
GuGcuccAGAAcucAucuudTsdT
sense


 


1048-1067
5051
AAGAUGAGUUCUGGAGCAC
5052
AAGAUGAGUUCUGGAGcACdTsdT
antis


 


1049-1068
5053
UGCUCCAGAACUCAUCUUU
5054
uGcuccAGAAcucAucuuudTsdT
sense


 


1049-1068
5055
AAAGAUGAGUUCUGGAGCA
5056
AAAGAUGAGUUCUGGAGcAdTsdT
antis


 


1050-1069
5057
GCUCCAGAACUCAUCUUUG
5058
GcuccAGAAcucAucuuuGdTsdT
sense


 


1050-1069
5059
CAAAGAUGAGUUCUGGAGC
5060
cAAAGAUGAGUUCUGGAGCdTsdT
antis


 


1059-1078
5061
CUCAUCUUUGGAGCCACAG
5062
cucAucuuuGGAGccAcAGdTsdT
sense


 


1059-1078
5063
CUGUGGCUCCAAAGAUGAG
5064
CUGUGGCUCcAAAGAUGAGdTsdT
antis


 


1087-1106
5065
CGUCCAUCGAUGUGUGGUC
5066
cGuccAucGAuGuGuGGucdTsdT
sense


 


1087-1106
5067
GACCACACAUCGAUGGACG
5068
GACcAcAcAUCGAUGGACGdTsdT
antis


 


1096-1115
5069
AUGUGUGGUCGGCUGGCUG
5070
AuGuGuGGucGGcuGGcuGdTsdT
sense


 


1096-1115
5071
CAGCCAGCCGACCACACAU
5072
cAGCcAGCCGACcAcAcAUdTsdT
antis


 


1130-1149
5073
ACUUCUCGGCCAGCCCAUC
5074
AcuucucGGccAGcccAucdTsdT
sense


 


1130-1149
5075
GAUGGGCUGGCCGAGAAGU
5076
GAUGGGCUGGCCGAGAAGUdTsdT
antis


 


1134-1153
5077
CUCGGCCAGCCCAUCUUCC
5078
cucGGccAGcccAucuuccdTsdT
sense


 


1134-1153
5079
GGAAGAUGGGCUGGCCGAG
5080
GGAAGAUGGGCUGGCCGAGdTsdT
antis


 


1141-1160
5081
AGCCCAUCUUCCCUGGGGA
5082
AGcccAucuucccuGGGGAdTsdT
sense


 


1141-1160
5083
UCCCCAGGGAAGAUGGGCU
5084
UCCCcAGGGAAGAUGGGCUdTsdT
antis


 


1144-1163
5085
CCAUCUUCCCUGGGGACAG
5086
ccAucuucccuGGGGAcAGdTsdT
sense


 


1144-1163
5087
CUGUCCCCAGGGAAGAUGG
5088
CUGUCCCcAGGGAAGAUGGdTsdT
antis


 


1151-1170
5089
CCCUGGGGACAGUGGGGUG
5090
cccuGGGGAcAGuGGGGuGdTsdT
sense


 


1151-1170
5091
CACCCCACUGUCCCCAGGG
5092
cACCCcACUGUCCCcAGGGdTsdT
antis


 


1156-1175
5093
GGGACAGUGGGGUGGACCA
5094
GGGAcAGuGGGGuGGAccAdTsdT
sense


 


1156-1175
5095
UGGUCCACCCCACUGUCCC
5096
UGGUCcACCCcACUGUCCCdTsdT
antis


 


1157-1176
5097
GGACAGUGGGGUGGACCAG
5098
GGAcAGuGGGGuGGAccAGdTsdT
sense


 


1157-1176
5099
CUGGUCCACCCCACUGUCC
5100
CUGGUCcACCCcACUGUCCdTsdT
antis


 


1158-1177
5101
GACAGUGGGGUGGACCAGC
5102
GAcAGuGGGGuGGAccAGcdTsdT
sense


 


1158-1177
5103
GCUGGUCCACCCCACUGUC
5104
GCUGGUCcACCCcACUGUCdTsdT
antis


 


1159-1178
5105
ACAGUGGGGUGGACCAGCU
5106
AcAGuGGGGuGGAccAGcudTsdT
sense


 


1159-1178
5107
AGCUGGUCCACCCCACUGU
5108
AGCUGGUCcACCCcACUGUdTsdT
antis


 


1160-1179
5109
CAGUGGGGUGGACCAGCUU
5110
cAGuGGGGuGGAccAGcuudTsdT
sense


 


1160-1179
5111
AAGCUGGUCCACCCCACUG
5112
AAGCUGGUCcACCCcACUGdTsdT
antis


 


1244-1263
5113
UACGGAGUUCAAGUUCCCC
5114
uAcGGAGuucAAGuuccccdTsdT
sense


 


1244-1263
5115
GGGGAACUUGAACUCCGUA
5116
GGGGAACUUGAACUCCGuAdTsdT
antis


 


1246-1265
5117
CGGAGUUCAAGUUCCCCCA
5118
cGGAGuucAAGuucccccAdTsdT
sense


 


1246-1265
5119
UGGGGGAACUUGAACUCCG
5120
UGGGGGAACUUGAACUCCGdTsdT
antis


 


1273-1292
5121
CUCACCCUUGGACAAAGGU
5122
cucAcccuuGGAcAAAGGudTsdT
sense


 


1273-1292
5123
ACCUUUGUCCAAGGGUGAG
5124
ACCUUUGUCcAAGGGUGAGdTsdT
antis


 


1275-1294
5125
CACCCUUGGACAAAGGUGU
5126
cAcccuuGGAcAAAGGuGudTsdT
sense


 


1275-1294
5127
ACACCUUUGUCCAAGGGUG
5128
AcACCUUUGUCcAAGGGUGdTsdT
antis


 


1278-1297
5129
CCUUGGACAAAGGUGUUCA
5130
ccuuGGAcAAAGGuGuucAdTsdT
sense


 


1278-1297
5131
UGAACACCUUUGUCCAAGG
5132
UGAAcACCUUUGUCcAAGGdTsdT
antis


 


1279-1298
5133
CUUGGACAAAGGUGUUCAA
5134
cuuGGAcAAAGGuGuucAAdTsdT
sense


 


1279-1298
5135
UUGAACACCUUUGUCCAAG
5136
UUGAAcACCUUUGUCcAAGdTsdT
antis


 


1288-1307
5137
AGGUGUUCAAAUCUUCAAA
5138
AGGuGuucAAAucuucAAAdTsdT
sense


 


1288-1307
5139
UUUGAAGAUUUGAACACCU
5140
UUUGAAGAUUUGAAcACCUdTsdT
antis


 


1291-1310
5141
UGUUCAAAUCUUCAAAGAC
5142
uGuucAAAucuucAAAGAcdTsdT
sense


 


1291-1310
5143
GUCUUUGAAGAUUUGAACA
5144
GUCUUUGAAGAUUUGAAcAdTsdT
antis


 


1292-1311
5145
GUUCAAAUCUUCAAAGACA
5146
GuucAAAucuucAAAGAcAdTsdT
sense


 


1292-1311
5147
UGUCUUUGAAGAUUUGAAC
5148
UGUCUUUGAAGAUUUGAACdTsdT
antis


 


1293-1312
5149
UUCAAAUCUUCAAAGACAC
5150
uucAAAucuucAAAGAcAcdTsdT
sense


 


1293-1312
5151
GUGUCUUUGAAGAUUUGAA
5152
GUGUCUUUGAAGAUUUGAAdTsdT
antis


 


1294-1313
5153
UCAAAUCUUCAAAGACACC
5154
ucAAAucuucAAAGAcAccdTsdT
sense


 


1294-1313
5155
GGUGUCUUUGAAGAUUUGA
5156
GGUGUCUUUGAAGAUUUGAdTsdT
antis


 


1314-1333
5157
CCUGAGGCCAUUGCACUCU
5158
ccuGAGGccAuuGcAcucudTsdT
sense


 


1314-1333
5159
AGAGUGCAAUGGCCUCAGG
5160
AGAGUGcAAUGGCCUcAGGdTsdT
antis


 


1320-1339
5161
GCCAUUGCACUCUGCUCUA
5162
GccAuuGcAcucuGcucuAdTsdT
sense


 


1320-1339
5163
UAGAGCAGAGUGCAAUGGC
5164
uAGAGcAGAGUGcAAUGGCdTsdT
antis


 


1336-1355
5165
CUAGCCUACUGGAGUACAC
5166
cuAGccuAcuGGAGuAcAcdTsdT
sense


 


1336-1355
5167
GUGUACUCCAGUAGGCUAG
5168
GUGuACUCcAGuAGGCuAGdTsdT
antis


 


1353-1372
5169
ACGCCAUCCUCAAGGCUCU
5170
AcGccAuccucAAGGcucudTsdT
sense


 


1353-1372
5171
AGAGCCUUGAGGAUGGCGU
5172
AGAGCCUUGAGGAUGGCGUdTsdT
antis


 


1355-1374
5173
GCCAUCCUCAAGGCUCUCC
5174
GccAuccucAAGGcucuccdTsdT
sense


 


1355-1374
5175
GGAGAGCCUUGAGGAUGGC
5176
GGAGAGCCUUGAGGAUGGCdTsdT
antis


 


1359-1378
5177
UCCUCAAGGCUCUCCCCAC
5178
uccucAAGGcucuccccAcdTsdT
sense


 


1359-1378
5179
GUGGGGAGAGCCUUGAGGA
5180
GUGGGGAGAGCCUUGAGGAdTsdT
antis


 


1372-1391
5181
CCCCACUCGAGGCUUGUGC
5182
ccccAcucGAGGcuuGuGcdTsdT
sense


 


1372-1391
5183
GCACAAGCCUCGAGUGGGG
5184
GcAcAAGCCUCGAGUGGGGdTsdT
antis


 


1373-1392
5185
CCCACUCGAGGCUUGUGCC
5186
cccAcucGAGGcuuGuGccdTsdT
sense


 


1373-1392
5187
GGCACAAGCCUCGAGUGGG
5188
GGcAcAAGCCUCGAGUGGGdTsdT
antis


 


1374-1393
5189
CCACUCGAGGCUUGUGCCC
5190
ccAcucGAGGcuuGuGcccdTsdT
sense


 


1374-1393
5191
GGGCACAAGCCUCGAGUGG
5192
GGGcAcAAGCCUCGAGUGGdTsdT
antis


 


1376-1395
5193
ACUCGAGGCUUGUGCCCAC
5194
AcucGAGGcuuGuGcccAcdTsdT
sense


 


1376-1395
5195
GUGGGCACAAGCCUCGAGU
5196
GUGGGcAcAAGCCUCGAGUdTsdT
antis


 


1377-1396
5197
CUCGAGGCUUGUGCCCACA
5198
cucGAGGcuuGuGcccAcAdTsdT
sense


 


1377-1396
5199
UGUGGGCACAAGCCUCGAG
5200
UGUGGGcAcAAGCCUCGAGdTsdT
antis


 


1378-1397
5201
UCGAGGCUUGUGCCCACAG
5202
ucGAGGcuuGuGcccAcAGdTsdT
sense


 


1378-1397
5203
CUGUGGGCACAAGCCUCGA
5204
CUGUGGGcAcAAGCCUCGAdTsdT
antis


 


1389-1408
5205
GCCCACAGCUUCUUCGAUG
5206
GcccAcAGcuucuucGAuGdTsdT
sense


 


1389-1408
5207
CAUCGAAGAAGCUGUGGGC
5208
cAUCGAAGAAGCUGUGGGCdTsdT
antis


 


1391-1410
5209
CCACAGCUUCUUCGAUGAA
5210
ccAcAGcuucuucGAuGAAdTsdT
sense


 


1391-1410
5211
UUCAUCGAAGAAGCUGUGG
5212
UUcAUCGAAGAAGCUGUGGdTsdT
antis


 


1423-1442
5213
GAGCCCAGCUCCCCAACGA
5214
GAGcccAGcuccccAAcGAdTsdT
sense


 


1423-1442
5215
UCGUUGGGGAGCUGGGCUC
5216
UCGUUGGGGAGCUGGGCUCdTsdT
antis


 


1469-1488
5217
CAGUCCUGGUGAACUGUCC
5218
cAGuccuGGuGAAcuGuccdTsdT
sense


 


1469-1488
5219
GGACAGUUCACCAGGACUG
5220
GGAcAGUUcACcAGGACUGdTsdT
antis


 


1484-1503
5221
GUCCAUCCAACCAUCUCUC
5222
GuccAuccAAccAucucucdTsdT
sense


 


1484-1503
5223
GAGAGAUGGUUGGAUGGAC
5224
GAGAGAUGGUUGGAUGGACdTsdT
antis


 


1496-1515
5225
AUCUCUCAAUGCCAUUCUC
5226
AucucucAAuGccAuucucdTsdT
sense


 


1496-1515
5227
GAGAAUGGCAUUGAGAGAU
5228
GAGAAUGGcAUUGAGAGAUdTsdT
antis


 


1498-1517
5229
CUCUCAAUGCCAUUCUCAU
5230
cucucAAuGccAuucucAudTsdT
sense


 


1498-1517
5231
AUGAGAAUGGCAUUGAGAG
5232
AUGAGAAUGGcAUUGAGAGdTsdT
antis


 


1499-1518
5233
UCUCAAUGCCAUUCUCAUC
5234
ucucAAuGccAuucucAucdTsdT
sense


 


1499-1518
5235
GAUGAGAAUGGCAUUGAGA
5236
GAUGAGAAUGGcAUUGAGAdTsdT
antis


 


1502-1521
5237
CAAUGCCAUUCUCAUCCCU
5238
cAAuGccAuucucAucccudTsdT
sense


 


1502-1521
5239
AGGGAUGAGAAUGGCAUUG
5240
AGGGAUGAGAAUGGcAUUGdTsdT
antis


 


1541-1560
5241
AGGCCCUGCUUCUCCCCUC
5242
AGGcccuGcuucuccccucdTsdT
sense


 


1541-1560
5243
GAGGGGAGAAGCAGGGCCU
5244
GAGGGGAGAAGcAGGGCCUdTsdT
antis


 


1542-1561
5245
GGCCCUGCUUCUCCCCUCA
5246
GGcccuGcuucuccccucAdTsdT
sense


 


1542-1561
5247
UGAGGGGAGAAGCAGGGCC
5248
UGAGGGGAGAAGcAGGGCCdTsdT
antis


 


1548-1567
5249
GCUUCUCCCCUCACCACUU
5250
GcuucuccccucAccAcuudTsdT
sense


 


1548-1567
5251
AAGUGGUGAGGGGAGAAGC
5252
AAGUGGUGAGGGGAGAAGCdTsdT
antis


 


1549-1568
5253
CUUCUCCCCUCACCACUUC
5254
cuucuccccucAccAcuucdTsdT
sense


 


1549-1568
5255
GAAGUGGUGAGGGGAGAAG
5256
GAAGUGGUGAGGGGAGAAGdTsdT
antis


 


1552-1571
5257
CUCCCCUCACCACUUCCUA
5258
cuccccucAccAcuuccuAdTsdT
sense


 


1552-1571
5259
UAGGAAGUGGUGAGGGGAG
5260
uAGGAAGUGGUGAGGGGAGdTsdT
antis


 


1557-1576
5261
CUCACCACUUCCUACAACC
5262
cucAccAcuuccuAcAAccdTsdT
sense


 


1557-1576
5263
GGUUGUAGGAAGUGGUGAG
5264
GGUUGuAGGAAGUGGUGAGdTsdT
antis


 


1575-1594
5265
CCAUCCUCACAAGCUUUAA
5266
ccAuccucAcAAGcuuuAAdTsdT
sense


 


1575-1594
5267
UUAAAGCUUGUGAGGAUGG
5268
UuAAAGCUUGUGAGGAUGGdTsdT
antis


 


1600-1619
5269
CUCAGACUGGCCAAGAUUG
5270
cucAGAcuGGccAAGAuuGdTsdT
sense


 


1600-1619
5271
CAAUCUUGGCCAGUCUGAG
5272
cAAUCUUGGCcAGUCUGAGdTsdT
antis


 


1616-1635
5273
UUGGCAGCCAUCUGAUGCC
5274
uuGGcAGccAucuGAuGccdTsdT
sense


 


1616-1635
5275
GGCAUCAGAUGGCUGCCAA
5276
GGcAUcAGAUGGCUGCcAAdTsdT
antis


 


1617-1636
5277
UGGCAGCCAUCUGAUGCCA
5278
uGGcAGccAucuGAuGccAdTsdT
sense


 


1617-1636
5279
UGGCAUCAGAUGGCUGCCA
5280
UGGcAUcAGAUGGCUGCcAdTsdT
antis


 


1618-1637
5281
GGCAGCCAUCUGAUGCCAC
5282
GGcAGccAucuGAuGccAcdTsdT
sense


 


1618-1637
5283
GUGGCAUCAGAUGGCUGCC
5284
GUGGcAUcAGAUGGCUGCCdTsdT
antis


 


1619-1638
5285
GCAGCCAUCUGAUGCCACA
5286
GcAGccAucuGAuGccAcAdTsdT
sense


 


1619-1638
5287
UGUGGCAUCAGAUGGCUGC
5288
UGUGGcAUcAGAUGGCUGCdTsdT
antis


 


1622-1641
5289
GCCAUCUGAUGCCACAACU
5290
GccAucuGAuGccAcAAcudTsdT
sense


 


1622-1641
5291
AGUUGUGGCAUCAGAUGGC
5292
AGUUGUGGcAUcAGAUGGCdTsdT
antis


 


1647-1666
5293
CUCGCUAGCUCUUCCUGAG
5294
cucGcuAGcucuuccuGAGdTsdT
sense


 


1647-1666
5295
CUCAGGAAGAGCUAGCGAG
5296
CUcAGGAAGAGCuAGCGAGdTsdT
antis


 


1648-1667
5297
UCGCUAGCUCUUCCUGAGG
5298
ucGcuAGcucuuccuGAGGdTsdT
sense


 


1648-1667
5299
CCUCAGGAAGAGCUAGCGA
5300
CCUcAGGAAGAGCuAGCGAdTsdT
antis


 


1649-1668
5301
CGCUAGCUCUUCCUGAGGG
5302
cGcuAGcucuuccuGAGGGdTsdT
sense


 


1649-1668
5303
CCCUCAGGAAGAGCUAGCG
5304
CCCUcAGGAAGAGCuAGCGdTsdT
antis


 


1658-1677
5305
UUCCUGAGGGCCCCACCGA
5306
uuccuGAGGGccccAccGAdTsdT
sense


 


1658-1677
5307
UCGGUGGGGCCCUCAGGAA
5308
UCGGUGGGGCCCUcAGGAAdTsdT
antis


 


1661-1680
5309
CUGAGGGCCCCACCGACUA
5310
cuGAGGGccccAccGAcuAdTsdT
sense


 


1661-1680
5311
UAGUCGGUGGGGCCCUCAG
5312
uAGUCGGUGGGGCCCUcAGdTsdT
antis


 


1662-1681
5313
UGAGGGCCCCACCGACUAC
5314
uGAGGGccccAccGAcuAcdTsdT
sense


 


1662-1681
5315
GUAGUCGGUGGGGCCCUCA
5316
GuAGUCGGUGGGGCCCUcAdTsdT
antis


 


1663-1682
5317
GAGGGCCCCACCGACUACC
5318
GAGGGccccAccGAcuAccdTsdT
sense


 


1663-1682
5319
GGUAGUCGGUGGGGCCCUC
5320
GGuAGUCGGUGGGGCCCUCdTsdT
antis


 


1800-1819
5321
AUCUAGGCCUCCCUCAGCA
5322
AucuAGGccucccucAGcAdTsdT
sense


 


1800-1819
5323
UGCUGAGGGAGGCCUAGAU
5324
UGCUGAGGGAGGCCuAGAUdTsdT
antis


 


1807-1826
5325
CCUCCCUCAGCAGCCUAAC
5326
ccucccucAGcAGccuAAcdTsdT
sense


 


1807-1826
5327
GUUAGGCUGCUGAGGGAGG
5328
GUuAGGCUGCUGAGGGAGGdTsdT
antis


 


1819-1838
5329
GCCUAACCUCUGUGGUGGG
5330
GccuAAccucuGuGGuGGGdTsdT
sense


 


1819-1838
5331
CCCACCACAGAGGUUAGGC
5332
CCcACcAcAGAGGUuAGGCdTsdT
antis


 


1856-1875
5333
AACUGUUUGUAGGGGAGGG
5334
AAcuGuuuGuAGGGGAGGGdTsdT
sense


 


1856-1875
5335
CCCUCCCCUACAAACAGUU
5336
CCCUCCCCuAcAAAcAGUUdTsdT
antis


 


1860-1879
5337
GUUUGUAGGGGAGGGGAGA
5338
GuuuGuAGGGGAGGGGAGAdTsdT
sense


 


1860-1879
5339
UCUCCCCUCCCCUACAAAC
5340
UCUCCCCUCCCCuAcAAACdTsdT
antis


 


1864-1883
5341
GUAGGGGAGGGGAGAAAAG
5342
GuAGGGGAGGGGAGAAAAGdTsdT
sense


 


1864-1883
5343
CUUUUCUCCCCUCCCCUAC
5344
CUUUUCUCCCCUCCCCuACdTsdT
antis


 


1879-1898
5345
AAAGGAAGGACGGGGUUUG
5346
AAAGGAAGGAcGGGGuuuGdTsdT
sense


 


1879-1898
5347
CAAACCCCGUCCUUCCUUU
5348
cAAACCCCGUCCUUCCUUUdTsdT
antis


 


1880-1899
5349
AAGGAAGGACGGGGUUUGG
5350
AAGGAAGGAcGGGGuuuGGdTsdT
sense


 


1880-1899
5351
CCAAACCCCGUCCUUCCUU
5352
CcAAACCCCGUCCUUCCUUdTsdT
antis


 


1881-1900
5353
AGGAAGGACGGGGUUUGGG
5354
AGGAAGGAcGGGGuuuGGGdTsdT
sense


 


1881-1900
5355
CCCAAACCCCGUCCUUCCU
5356
CCcAAACCCCGUCCUUCCUdTsdT
antis


 


1906-1925
5357
AGGACCUUCUACCCCCUUG
5358
AGGAccuucuAcccccuuGdTsdT
sense


 


1906-1925
5359
CAAGGGGGUAGAAGGUCCU
5360
cAAGGGGGuAGAAGGUCCUdTsdT
antis


 


1907-1926
5361
GGACCUUCUACCCCCUUGG
5362
GGAccuucuAcccccuuGGdTsdT
sense


 


1907-1926
5363
CCAAGGGGGUAGAAGGUCC
5364
CcAAGGGGGuAGAAGGUCCdTsdT
antis


 


1908-1927
5365
GACCUUCUACCCCCUUGGU
5366
GAccuucuAcccccuuGGudTsdT
sense


 


1908-1927
5367
ACCAAGGGGGUAGAAGGUC
5368
ACcAAGGGGGuAGAAGGUCdTsdT
antis


 


1909-1928
5369
ACCUUCUACCCCCUUGGUC
5370
AccuucuAcccccuuGGucdTsdT
sense


 


1909-1928
5371
GACCAAGGGGGUAGAAGGU
5372
GACcAAGGGGGuAGAAGGUdTsdT
antis


 


1910-1929
5373
CCUUCUACCCCCUUGGUCC
5374
ccuucuAcccccuuGGuccdTsdT
sense


 


1910-1929
5375
GGACCAAGGGGGUAGAAGG
5376
GGACcAAGGGGGuAGAAGGdTsdT
antis


 


1911-1930
5377
CUUCUACCCCCUUGGUCCC
5378
cuucuAcccccuuGGucccdTsdT
sense


 


1911-1930
5379
GGGACCAAGGGGGUAGAAG
5380
GGGACcAAGGGGGuAGAAGdTsdT
antis


 


1932-1951
5381
CCCCUCCCCCAGGCUACCA
5382
ccccucccccAGGcuAccAdTsdT
sense


 


1932-1951
5383
UGGUAGCCUGGGGGAGGGG
5384
UGGuAGCCUGGGGGAGGGGdTsdT
antis


 


1942-1961
5385
AGGCUACCACUCCUUCCCU
5386
AGGcuAccAcuccuucccudTsdT
sense


 


1942-1961
5387
AGGGAAGGAGUGGUAGCCU
5388
AGGGAAGGAGUGGuAGCCUdTsdT
antis


 


1943-1962
5389
GGCUACCACUCCUUCCCUC
5390
GGcuAccAcuccuucccucdTsdT
sense


 


1943-1962
5391
GAGGGAAGGAGUGGUAGCC
5392
GAGGGAAGGAGUGGuAGCCdTsdT
antis


 


1958-1977
5393
CCUCCCCCCCUCUCCCAGG
5394
ccucccccccucucccAGGdTsdT
sense


 


1958-1977
5395
CCUGGGAGAGGGGGGGAGG
5396
CCUGGGAGAGGGGGGGAGGdTsdT
antis


 


1961-1980
5397
CCCCCCCUCUCCCAGGUCC
5398
cccccccucucccAGGuccdTsdT
sense


 


1961-1980
5399
GGACCUGGGAGAGGGGGGG
5400
GGACCUGGGAGAGGGGGGGdTsdT
antis


 


1966-1985
5401
CCUCUCCCAGGUCCCUUGU
5402
ccucucccAGGucccuuGudTsdT
sense


 


1966-1985
5403
ACAAGGGACCUGGGAGAGG
5404
AcAAGGGACCUGGGAGAGGdTsdT
antis


 


1972-1991
5405
CCAGGUCCCUUGUAAAUAG
5406
ccAGGucccuuGuAAAuAGdTsdT
sense


 


1972-1991
5407
CUAUUUACAAGGGACCUGG
5408
CuAUUuAcAAGGGACCUGGdTsdT
antis


 


1989-2008
5409
AGAACCAGCCCAGCCCAUC
5410
AGAAccAGcccAGcccAucdTsdT
sense


 


1989-2008
5411
GAUGGGCUGGGCUGGUUCU
5412
GAUGGGCUGGGCUGGUUCUdTsdT
antis


 


1990-2009
5413
GAACCAGCCCAGCCCAUCU
5414
GAAccAGcccAGcccAucudTsdT
sense


 


1990-2009
5415
AGAUGGGCUGGGCUGGUUC
5416
AGAUGGGCUGGGCUGGUUCdTsdT
antis


 


1991-2010
5417
AACCAGCCCAGCCCAUCUC
5418
AAccAGcccAGcccAucucdTsdT
sense


 


1991-2010
5419
GAGAUGGGCUGGGCUGGUU
5420
GAGAUGGGCUGGGCUGGUUdTsdT
antis


 


1992-2011
5421
ACCAGCCCAGCCCAUCUCU
5422
AccAGcccAGcccAucucudTsdT
sense


 


1992-2011
5423
AGAGAUGGGCUGGGCUGGU
5424
AGAGAUGGGCUGGGCUGGUdTsdT
antis


 


1993-2012
5425
CCAGCCCAGCCCAUCUCUC
5426
ccAGcccAGcccAucucucdTsdT
sense


 


1993-2012
5427
GAGAGAUGGGCUGGGCUGG
5428
GAGAGAUGGGCUGGGCUGGdTsdT
antis


 


2007-2026
5429
CUCUCGUCUUCCCUUCCCU
5430
cucucGucuucccuucccudTsdT
sense


 


2007-2026
5431
AGGGAAGGGAAGACGAGAG
5432
AGGGAAGGGAAGACGAGAGdTsdT
antis


 


2008-2027
5433
UCUCGUCUUCCCUUCCCUG
5434
ucucGucuucccuucccuGdTsdT
sense


 


2008-2027
5435
CAGGGAAGGGAAGACGAGA
5436
cAGGGAAGGGAAGACGAGAdTsdT
antis


 


2013-2032
5437
UCUUCCCUUCCCUGGCCCC
5438
ucuucccuucccuGGccccdTsdT
sense


 


2013-2032
5439
GGGGCCAGGGAAGGGAAGA
5440
GGGGCcAGGGAAGGGAAGAdTsdT
antis


 


2014-2033
5441
CUUCCCUUCCCUGGCCCCC
5442
cuucccuucccuGGcccccdTsdT
sense


 


2014-2033
5443
GGGGGCCAGGGAAGGGAAG
5444
GGGGGCcAGGGAAGGGAAGdTsdT
antis


 


2021-2040
5445
UCCCUGGCCCCCUGGGUGU
5446
ucccuGGcccccuGGGuGudTsdT
sense


 


2021-2040
5447
ACACCCAGGGGGCCAGGGA
5448
AcACCcAGGGGGCcAGGGAdTsdT
antis


 


2038-2057
5449
GUAAAUAGAUUGUUAUAAU
5450
GuAAAuAGAuuGuuAuAAudTsdT
sense


 


2038-2057
5451
AUUAUAACAAUCUAUUUAC
5452
AUuAuAAcAAUCuAUUuACdTsdT
antis


 


2048-2067
5453
UGUUAUAAUUUUUUCUUAA
5454
uGuuAuAAuuuuuucuuAAdTsdT
sense


 


2048-2067
5455
UUAAGAAAAAAUUAUAACA
5456
UuAAGAAAAAAUuAuAAcAdTsdT
antis


 


2106-2125
5457
GCUGUACCCCUUCUUGUCC
5458
GcuGuAccccuucuuGuccdTsdT
sense


 


2106-2125
5459
GGACAAGAAGGGGUACAGC
5460
GGAcAAGAAGGGGuAcAGCdTsdT
antis


 


2109-2128
5461
GUACCCCUUCUUGUCCUCU
5462
GuAccccuucuuGuccucudTsdT
sense


 


2109-2128
5463
AGAGGACAAGAAGGGGUAC
5464
AGAGGAcAAGAAGGGGuACdTsdT
antis


 


2120-2139
5465
UGUCCUCUGCUCCCAAGGC
5466
uGuccucuGcucccAAGGcdTsdT
sense


 


2120-2139
5467
GCCUUGGGAGCAGAGGACA
5468
GCCUUGGGAGcAGAGGAcAdTsdT
antis


 


2170-2189
5469
AGUAGAGAGAGUCCCUGGU
5470
AGuAGAGAGAGucccuGGudTsdT
sense


 


2170-2189
5471
ACCAGGGACUCUCUCUACU
5472
ACcAGGGACUCUCUCuACUdTsdT
antis


 


2180-2199
5473
GUCCCUGGUGUCUUAGUUU
5474
GucccuGGuGucuuAGuuudTsdT
sense


 


2180-2199
5475
AAACUAAGACACCAGGGAC
5476
AAACuAAGAcACcAGGGACdTsdT
antis


 


2187-2206
5477
GUGUCUUAGUUUCCACAGU
5478
GuGucuuAGuuuccAcAGudTsdT
sense


 


2187-2206
5479
ACUGUGGAAACUAAGACAC
5480
ACUGUGGAAACuAAGAcACdTsdT
antis


 


2189-2208
5481
GUCUUAGUUUCCACAGUAA
5482
GucuuAGuuuccAcAGuAAdTsdT
sense


 


2189-2208
5483
UUACUGUGGAAACUAAGAC
5484
UuACUGUGGAAACuAAGACdTsdT
antis


 


2190-2209
5485
UCUUAGUUUCCACAGUAAG
5486
ucuuAGuuuccAcAGuAAGdTsdT
sense


 


2190-2209
5487
CUUACUGUGGAAACUAAGA
5488
CUuACUGUGGAAACuAAGAdTsdT
antis


 


2225-2244
5489
ACCUCUGUUCAAUAAAUUA
5490
AccucuGuucAAuAAAuuAdTsdT
sense


 


2225-2244
5491
UAAUUUAUUGAACAGAGGU
5492
uAAUUuAUUGAAcAGAGGUdTsdT
antis


 


2238-2257
5493
AAAUUAUUGGCAUGAAACC
5494
AAAuuAuuGGcAuGAAAccdTsdT
sense


 


2238-2257
5495
GGUUUCAUGCCAAUAAUUU
5496
GGUUUcAUGCcAAuAAUUUdTsdT
antis


 


2239-2258
5497
AAUUAUUGGCAUGAAACCC
5498
AAuuAuuGGcAuGAAAcccdTsdT
sense


 


2239-2258
5499
GGGUUUCAUGCCAAUAAUU
5500
GGGUUUcAUGCcAAuAAUUdTsdT
antis


 


2241-2260
5501
UUAUUGGCAUGAAACCCUU
5502
uuAuuGGcAuGAAAcccuudTsdT
sense


 


2241-2260
5503
AAGGGUUUCAUGCCAAUAA
5504
AAGGGUUUcAUGCcAAuAAdTsdT
antis


 


34-53
5505
CAUCUCCCGGCGUGCCCCG
5506
cAucucccGGcGuGccccGdTsdT
sense


 


34-53
5507
CGGGGCACGCCGGGAGAUG
5508
CGGGGcACGCCGGGAGAUGdTsdT
antis


 


35-54
5509
AUCUCCCGGCGUGCCCCGC
5510
AucucccGGcGuGccccGcdTsdT
sense


 


35-54
5511
GCGGGGCACGCCGGGAGAU
5512
GCGGGGcACGCCGGGAGAUdTsdT
antis


 


 97-116
5513
GAAGAGGCCGGAGCCCAGG
5514
GAAGAGGccGGAGcccAGGdTsdT
sense


 


 97-116
5515
CCUGGGCUCCGGCCUCUUC
5516
CCUGGGCUCCGGCCUCUUCdTsdT
antis


 


163-182
5517
CCCCGCGGCCUGGGCCUGC
5518
ccccGcGGccuGGGccuGcdTsdT
sense


 


163-182
5519
GCAGGCCCAGGCCGCGGGG
5520
GcAGGCCcAGGCCGCGGGGdTsdT
antis


 


164-183
5521
CCCGCGGCCUGGGCCUGCG
5522
cccGcGGccuGGGccuGcGdTsdT
sense


 


164-183
5523
CGCAGGCCCAGGCCGCGGG
5524
CGcAGGCCcAGGCCGCGGGdTsdT
antis


 


228-247
5525
GGCUCGGGCCGGGCGCGGA
5526
GGcucGGGccGGGcGcGGAdTsdT
sense


 


228-247
5527
UCCGCGCCCGGCCCGAGCC
5528
UCCGCGCCCGGCCCGAGCCdTsdT
antis


 


235-254
5529
GCCGGGCGCGGACCAGCUC
5530
GccGGGcGcGGAccAGcucdTsdT
sense


 


235-254
5531
GAGCUGGUCCGCGCCCGGC
5532
GAGCUGGUCCGCGCCCGGCdTsdT
antis


 


247-266
5533
CCAGCUCGUUCGCGGAGCC
5534
ccAGcucGuucGcGGAGccdTsdT
sense


 


247-266
5535
GGCUCCGCGAACGAGCUGG
5536
GGCUCCGCGAACGAGCUGGdTsdT
antis


 


262-281
5537
AGCCAGGAGGCGGAGGCGG
5538
AGccAGGAGGcGGAGGcGGdTsdT
sense


 


262-281
5539
CCGCCUCCGCCUCCUGGCU
5540
CCGCCUCCGCCUCCUGGCUdTsdT
antis


 


301-320
5541
GGGGCUCGGCCUCUGGCCC
5542
GGGGcucGGccucuGGcccdTsdT
sense


 


301-320
5543
GGGCCAGAGGCCGAGCCCC
5544
GGGCcAGAGGCCGAGCCCCdTsdT
antis


 


393-412
5545
GGCCCCAGCGGCAGCGGCG
5546
GGccccAGcGGcAGcGGcGdTsdT
sense


 


393-412
5547
CGCCGCUGCCGCUGGGGCC
5548
CGCCGCUGCCGCUGGGGCCdTsdT
antis


 


403-422
5549
GCAGCGGCGGAGGAGGCAG
5550
GcAGcGGcGGAGGAGGcAGdTsdT
sense


 


403-422
5551
CUGCCUCCUCCGCCGCUGC
5552
CUGCCUCCUCCGCCGCUGCdTsdT
antis


 


420-439
5553
AGCGGUGGCCCCGGCGCGG
5554
AGcGGuGGccccGGcGcGGdTsdT
sense


 


420-439
5555
CCGCGCCGGGGCCACCGCU
5556
CCGCGCCGGGGCcACCGCUdTsdT
antis


 


502-521
5557
UAGCCACUGUAGGCCAAGG
5558
uAGccAcuGuAGGccAAGGdTsdT
sense


 


502-521
5559
CCUUGGCCUACAGUGGCUA
5560
CCUUGGCCuAcAGUGGCuAdTsdT
antis


 


531-550
5561
UCCCAAGAAGUGGCUUACA
5562
ucccAAGAAGuGGcuuAcAdTsdT
sense


 


531-550
5563
UGUAAGCCACUUCUUGGGA
5564
UGuAAGCcACUUCUUGGGAdTsdT
antis


 


665-684
5565
CCGAGAACUGCAGAUUAUG
5566
ccGAGAAcuGcAGAuuAuGdTsdT
sense


 


665-684
5567
CAUAAUCUGCAGUUCUCGG
5568
cAuAAUCUGcAGUUCUCGGdTsdT
antis


 


1148-1167
5569
CUUCCCUGGGGACAGUGGG
5570
cuucccuGGGGAcAGuGGGdTsdT
sense


 


1148-1167
5571
CCCACUGUCCCCAGGGAAG
5572
CCcACUGUCCCcAGGGAAGdTsdT
antis


 


1356-1375
5573
CCAUCCUCAAGGCUCUCCC
5574
ccAuccucAAGGcucucccdTsdT
sense


 


1356-1375
5575
GGGAGAGCCUUGAGGAUGG
5576
GGGAGAGCCUUGAGGAUGGdTsdT
antis


 


1358-1377
5577
AUCCUCAAGGCUCUCCCCA
5578
AuccucAAGGcucuccccAdTsdT
sense


 


1358-1377
5579
UGGGGAGAGCCUUGAGGAU
5580
UGGGGAGAGCCUUGAGGAUdTsdT
antis


 


1485-1504
5581
UCCAUCCAACCAUCUCUCA
5582
uccAuccAAccAucucucAdTsdT
sense


 


1485-1504
5583
UGAGAGAUGGUUGGAUGGA
5584
UGAGAGAUGGUUGGAUGGAdTsdT
antis


 


1620-1639
5585
CAGCCAUCUGAUGCCACAA
5586
cAGccAucuGAuGccAcAAdTsdT
sense


 


1620-1639
5587
UUGUGGCAUCAGAUGGCUG
5588
UUGUGGcAUcAGAUGGCUGdTsdT
antis


 


1813-1832
5589
UCAGCAGCCUAACCUCUGU
5590
ucAGcAGccuAAccucuGudTsdT
sense


 


1813-1832
5591
ACAGAGGUUAGGCUGCUGA
5592
AcAGAGGUuAGGCUGCUGAdTsdT
antis


 


1954-1973
5593
CUUCCCUCCCCCCCUCUCC
5594
cuucccucccccccucuccdTsdT
sense


 


1954-1973
5595
GGAGAGGGGGGGAGGGAAG
5596
GGAGAGGGGGGGAGGGAAGdTsdT
antis


 


1957-1976
5597
CCCUCCCCCCCUCUCCCAG
5598
cccucccccccucucccAGdTsdT
sense


 


1957-1976
5599
CUGGGAGAGGGGGGGAGGG
5600
CUGGGAGAGGGGGGGAGGGdTsdT
antis


 


2103-2122
5601
CCAGCUGUACCCCUUCUUG
5602
ccAGcuGuAccccuucuuGdTsdT
sense


 


2103-2122
5603
CAAGAAGGGGUACAGCUGG
5604
cAAGAAGGGGuAcAGCUGGdTsdT
antis


 


2119-2138
5605
UUGUCCUCUGCUCCCAAGG
5606
uuGuccucuGcucccAAGGdTsdT
sense


 


2119-2138
5607
CCUUGGGAGCAGAGGACAA
5608
CCUUGGGAGcAGAGGAcAAdTsdT
antis


 


2122-2141
5609
UCCUCUGCUCCCAAGGCUU
5610
uccucuGcucccAAGGcuudTsdT
sense


 


2122-2141
5611
AAGCCUUGGGAGCAGAGGA
5612
AAGCCUUGGGAGcAGAGGAdTsdT
antis


 


2125-2144
5613
UCUGCUCCCAAGGCUUCCU
5614
ucuGcucccAAGGcuuccudTsdT
sense


 


2125-2144
5615
AGGAAGCCUUGGGAGCAGA
5616
AGGAAGCCUUGGGAGcAGAdTsdT
antis


 


2154-2173
5617
AUCCUGGAAGGAGGGGAGU
5618
AuccuGGAAGGAGGGGAGudTsdT
sense


 


2154-2173
5619
ACUCCCCUCCUUCCAGGAU
5620
ACUCCCCUCCUUCcAGGAUdTsdT
antis


 


33-52
5621
UCAUCUCCCGGCGUGCCCC
5622
ucAucucccGGcGuGccccdTsdT
sense


 


33-52
5623
GGGGCACGCCGGGAGAUGA
5624
GGGGcACGCCGGGAGAUGAdTsdT
antis


 


46-65
5625
UGCCCCGCGGCGGGCGCUG
5626
uGccccGcGGcGGGcGcuGdTsdT
sense


 


46-65
5627
CAGCGCCCGCCGCGGGGCA
5628
cAGCGCCCGCCGCGGGGcAdTsdT
antis


 


47-66
5629
GCCCCGCGGCGGGCGCUGG
5630
GccccGcGGcGGGcGcuGGdTsdT
sense


 


47-66
5631
CCAGCGCCCGCCGCGGGGC
5632
CcAGCGCCCGCCGCGGGGCdTsdT
antis


 


53-72
5633
CGGCGGGCGCUGGGCCGGA
5634
cGGcGGGcGcuGGGccGGAdTsdT
sense


 


53-72
5635
UCCGGCCCAGCGCCCGCCG
5636
UCCGGCCcAGCGCCCGCCGdTsdT
antis


 


54-73
5637
GGCGGGCGCUGGGCCGGAG
5638
GGcGGGcGcuGGGccGGAGdTsdT
sense


 


54-73
5639
CUCCGGCCCAGCGCCCGCC
5640
CUCCGGCCcAGCGCCCGCCdTsdT
antis


 


55-74
5641
GCGGGCGCUGGGCCGGAGC
5642
GcGGGcGcuGGGccGGAGcdTsdT
sense


 


55-74
5643
GCUCCGGCCCAGCGCCCGC
5644
GCUCCGGCCcAGCGCCCGCdTsdT
antis


 


61-80
5645
GCUGGGCCGGAGCCGGAGC
5646
GcuGGGccGGAGccGGAGcdTsdT
sense


 


61-80
5647
GCUCCGGCUCCGGCCCAGC
5648
GCUCCGGCUCCGGCCcAGCdTsdT
antis


 


64-83
5649
GGGCCGGAGCCGGAGCCCG
5650
GGGccGGAGccGGAGcccGdTsdT
sense


 


64-83
5651
CGGGCUCCGGCUCCGGCCC
5652
CGGGCUCCGGCUCCGGCCCdTsdT
antis


 


67-86
5653
CCGGAGCCGGAGCCCGAAC
5654
ccGGAGccGGAGcccGAAcdTsdT
sense


 


67-86
5655
GUUCGGGCUCCGGCUCCGG
5656
GUUCGGGCUCCGGCUCCGGdTsdT
antis


 


 92-111
5657
GCCUGGAAGAGGCCGGAGC
5658
GccuGGAAGAGGccGGAGcdTsdT
sense


 


 92-111
5659
GCUCCGGCCUCUUCCAGGC
5660
GCUCCGGCCUCUUCcAGGCdTsdT
antis


 


 93-112
5661
CCUGGAAGAGGCCGGAGCC
5662
ccuGGAAGAGGccGGAGccdTsdT
sense


 


 93-112
5663
GGCUCCGGCCUCUUCCAGG
5664
GGCUCCGGCCUCUUCcAGGdTsdT
antis


 


101-120
5665
AGGCCGGAGCCCAGGGGAG
5666
AGGccGGAGcccAGGGGAGdTsdT
sense


 


101-120
5667
CUCCCCUGGGCUCCGGCCU
5668
CUCCCCUGGGCUCCGGCCUdTsdT
antis


 


102-121
5669
GGCCGGAGCCCAGGGGAGG
5670
GGccGGAGcccAGGGGAGGdTsdT
sense


 


102-121
5671
CCUCCCCUGGGCUCCGGCC
5672
CCUCCCCUGGGCUCCGGCCdTsdT
antis


 


106-125
5673
GGAGCCCAGGGGAGGCGGC
5674
GGAGcccAGGGGAGGcGGcdTsdT
sense


 


106-125
5675
GCCGCCUCCCCUGGGCUCC
5676
GCCGCCUCCCCUGGGCUCCdTsdT
antis


 


110-129
5677
CCCAGGGGAGGCGGCGGCA
5678
cccAGGGGAGGcGGcGGcAdTsdT
sense


 


110-129
5679
UGCCGCCGCCUCCCCUGGG
5680
UGCCGCCGCCUCCCCUGGGdTsdT
antis


 


111-130
5681
CCAGGGGAGGCGGCGGCAG
5682
ccAGGGGAGGcGGcGGcAGdTsdT
sense


 


111-130
5683
CUGCCGCCGCCUCCCCUGG
5684
CUGCCGCCGCCUCCCCUGGdTsdT
antis


 


122-141
5685
GGCGGCAGAGGCAGCGGCG
5686
GGcGGcAGAGGcAGcGGcGdTsdT
sense


 


122-141
5687
CGCCGCUGCCUCUGCCGCC
5688
CGCCGCUGCCUCUGCCGCCdTsdT
antis


 


123-142
5689
GCGGCAGAGGCAGCGGCGG
5690
GcGGcAGAGGcAGcGGcGGdTsdT
sense


 


123-142
5691
CCGCCGCUGCCUCUGCCGC
5692
CCGCCGCUGCCUCUGCCGCdTsdT
antis


 


124-143
5693
CGGCAGAGGCAGCGGCGGG
5694
cGGcAGAGGcAGcGGcGGGdTsdT
sense


 


124-143
5695
CCCGCCGCUGCCUCUGCCG
5696
CCCGCCGCUGCCUCUGCCGdTsdT
antis


 


125-144
5697
GGCAGAGGCAGCGGCGGGG
5698
GGcAGAGGcAGcGGcGGGGdTsdT
sense


 


125-144
5699
CCCCGCCGCUGCCUCUGCC
5700
CCCCGCCGCUGCCUCUGCCdTsdT
antis


 


132-151
5701
GCAGCGGCGGGGGCAGCCC
5702
GcAGcGGcGGGGGcAGcccdTsdT
sense


 


132-151
5703
GGGCUGCCCCCGCCGCUGC
5704
GGGCUGCCCCCGCCGCUGCdTsdT
antis


 


139-158
5705
CGGGGGCAGCCCAGGCAGC
5706
cGGGGGcAGcccAGGcAGcdTsdT
sense


 


139-158
5707
GCUGCCUGGGCUGCCCCCG
5708
GCUGCCUGGGCUGCCCCCGdTsdT
antis


 


143-162
5709
GGCAGCCCAGGCAGCCCGA
5710
GGcAGcccAGGcAGcccGAdTsdT
sense


 


143-162
5711
UCGGGCUGCCUGGGCUGCC
5712
UCGGGCUGCCUGGGCUGCCdTsdT
antis


 


146-165
5713
AGCCCAGGCAGCCCGAGCC
5714
AGcccAGGcAGcccGAGccdTsdT
sense


 


146-165
5715
GGCUCGGGCUGCCUGGGCU
5716
GGCUCGGGCUGCCUGGGCUdTsdT
antis


 


152-171
5717
GGCAGCCCGAGCCCCGCGG
5718
GGcAGcccGAGccccGcGGdTsdT
sense


 


152-171
5719
CCGCGGGGCUCGGGCUGCC
5720
CCGCGGGGCUCGGGCUGCCdTsdT
antis


 


154-173
5721
CAGCCCGAGCCCCGCGGCC
5722
cAGcccGAGccccGcGGccdTsdT
sense


 


154-173
5723
GGCCGCGGGGCUCGGGCUG
5724
GGCCGCGGGGCUCGGGCUGdTsdT
antis


 


155-174
5725
AGCCCGAGCCCCGCGGCCU
5726
AGcccGAGccccGcGGccudTsdT
sense


 


155-174
5727
AGGCCGCGGGGCUCGGGCU
5728
AGGCCGCGGGGCUCGGGCUdTsdT
antis


 


156-175
5729
GCCCGAGCCCCGCGGCCUG
5730
GcccGAGccccGcGGccuGdTsdT
sense


 


156-175
5731
CAGGCCGCGGGGCUCGGGC
5732
cAGGCCGCGGGGCUCGGGCdTsdT
antis


 


159-178
5733
CGAGCCCCGCGGCCUGGGC
5734
cGAGccccGcGGccuGGGcdTsdT
sense


 


159-178
5735
GCCCAGGCCGCGGGGCUCG
5736
GCCcAGGCCGCGGGGCUCGdTsdT
antis


 


160-179
5737
GAGCCCCGCGGCCUGGGCC
5738
GAGccccGcGGccuGGGccdTsdT
sense


 


160-179
5739
GGCCCAGGCCGCGGGGCUC
5740
GGCCcAGGCCGCGGGGCUCdTsdT
antis


 


161-180
5741
AGCCCCGCGGCCUGGGCCU
5742
AGccccGcGGccuGGGccudTsdT
sense


 


161-180
5743
AGGCCCAGGCCGCGGGGCU
5744
AGGCCcAGGCCGCGGGGCUdTsdT
antis


 


162-181
5745
GCCCCGCGGCCUGGGCCUG
5746
GccccGcGGccuGGGccuGdTsdT
sense


 


162-181
5747
CAGGCCCAGGCCGCGGGGC
5748
cAGGCCcAGGCCGCGGGGCdTsdT
antis


 


174-193
5749
GGGCCUGCGCUCGGCGCCA
5750
GGGccuGcGcucGGcGccAdTsdT
sense


 


174-193
5751
UGGCGCCGAGCGCAGGCCC
5752
UGGCGCCGAGCGcAGGCCCdTsdT
antis


 


210-229
5753
UCGGGAGGCGGCCCUGGGG
5754
ucGGGAGGcGGcccuGGGGdTsdT
sense


 


210-229
5755
CCCCAGGGCCGCCUCCCGA
5756
CCCcAGGGCCGCCUCCCGAdTsdT
antis


 


211-230
5757
CGGGAGGCGGCCCUGGGGG
5758
cGGGAGGcGGcccuGGGGGdTsdT
sense


 


211-230
5759
CCCCCAGGGCCGCCUCCCG
5760
CCCCcAGGGCCGCCUCCCGdTsdT
antis


 


212-231
5761
GGGAGGCGGCCCUGGGGGC
5762
GGGAGGcGGcccuGGGGGcdTsdT
sense


 


212-231
5763
GCCCCCAGGGCCGCCUCCC
5764
GCCCCcAGGGCCGCCUCCCdTsdT
antis


 


217-236
5765
GCGGCCCUGGGGGCUCGGG
5766
GcGGcccuGGGGGcucGGGdTsdT
sense


 


217-236
5767
CCCGAGCCCCCAGGGCCGC
5768
CCCGAGCCCCcAGGGCCGCdTsdT
antis


 


218-237
5769
CGGCCCUGGGGGCUCGGGC
5770
cGGcccuGGGGGcucGGGcdTsdT
sense


 


218-237
5771
GCCCGAGCCCCCAGGGCCG
5772
GCCCGAGCCCCcAGGGCCGdTsdT
antis


 


225-244
5773
GGGGGCUCGGGCCGGGCGC
5774
GGGGGcucGGGccGGGcGcdTsdT
sense


 


225-244
5775
GCGCCCGGCCCGAGCCCCC
5776
GCGCCCGGCCCGAGCCCCCdTsdT
antis


 


226-245
5777
GGGGCUCGGGCCGGGCGCG
5778
GGGGcucGGGccGGGcGcGdTsdT
sense


 


226-245
5779
CGCGCCCGGCCCGAGCCCC
5780
CGCGCCCGGCCCGAGCCCCdTsdT
antis


 


232-251
5781
CGGGCCGGGCGCGGACCAG
5782
cGGGccGGGcGcGGAccAGdTsdT
sense


 


232-251
5783
CUGGUCCGCGCCCGGCCCG
5784
CUGGUCCGCGCCCGGCCCGdTsdT
antis


 


260-279
5785
GGAGCCAGGAGGCGGAGGC
5786
GGAGccAGGAGGcGGAGGcdTsdT
sense


 


260-279
5787
GCCUCCGCCUCCUGGCUCC
5788
GCCUCCGCCUCCUGGCUCCdTsdT
antis


 


263-282
5789
GCCAGGAGGCGGAGGCGGA
5790
GccAGGAGGcGGAGGcGGAdTsdT
sense


 


263-282
5791
UCCGCCUCCGCCUCCUGGC
5792
UCCGCCUCCGCCUCCUGGCdTsdT
antis


 


264-283
5793
CCAGGAGGCGGAGGCGGAG
5794
ccAGGAGGcGGAGGcGGAGdTsdT
sense


 


264-283
5795
CUCCGCCUCCGCCUCCUGG
5796
CUCCGCCUCCGCCUCCUGGdTsdT
antis


 


270-289
5797
GGCGGAGGCGGAGGUGGUG
5798
GGcGGAGGcGGAGGuGGuGdTsdT
sense


 


270-289
5799
CACCACCUCCGCCUCCGCC
5800
cACcACCUCCGCCUCCGCCdTsdT
antis


 


280-299
5801
GAGGUGGUGGCGGCGGCCC
5802
GAGGuGGuGGcGGcGGcccdTsdT
sense


 


280-299
5803
GGGCCGCCGCCACCACCUC
5804
GGGCCGCCGCcACcACCUCdTsdT
antis


 


281-300
5805
AGGUGGUGGCGGCGGCCCC
5806
AGGuGGuGGcGGcGGccccdTsdT
sense


 


281-300
5807
GGGGCCGCCGCCACCACCU
5808
GGGGCCGCCGCcACcACCUdTsdT
antis


 


282-301
5809
GGUGGUGGCGGCGGCCCCG
5810
GGuGGuGGcGGcGGccccGdTsdT
sense


 


282-301
5811
CGGGGCCGCCGCCACCACC
5812
CGGGGCCGCCGCcACcACCdTsdT
antis


 


283-302
5813
GUGGUGGCGGCGGCCCCGG
5814
GuGGuGGcGGcGGccccGGdTsdT
sense


 


283-302
5815
CCGGGGCCGCCGCCACCAC
5816
CCGGGGCCGCCGCcACcACdTsdT
antis


 


289-308
5817
GCGGCGGCCCCGGGGGCUC
5818
GcGGcGGccccGGGGGcucdTsdT
sense


 


289-308
5819
GAGCCCCCGGGGCCGCCGC
5820
GAGCCCCCGGGGCCGCCGCdTsdT
antis


 


291-310
5821
GGCGGCCCCGGGGGCUCGG
5822
GGcGGccccGGGGGcucGGdTsdT
sense


 


291-310
5823
CCGAGCCCCCGGGGCCGCC
5824
CCGAGCCCCCGGGGCCGCCdTsdT
antis


 


296-315
5825
CCCCGGGGGCUCGGCCUCU
5826
ccccGGGGGcucGGccucudTsdT
sense


 


296-315
5827
AGAGGCCGAGCCCCCGGGG
5828
AGAGGCCGAGCCCCCGGGGdTsdT
antis


 


303-322
5829
GGCUCGGCCUCUGGCCCAG
5830
GGcucGGccucuGGcccAGdTsdT
sense


 


303-322
5831
CUGGGCCAGAGGCCGAGCC
5832
CUGGGCcAGAGGCCGAGCCdTsdT
antis


 


320-339
5833
AGGAGGCACUGGCGGCGGG
5834
AGGAGGcAcuGGcGGcGGGdTsdT
sense


 


320-339
5835
CCCGCCGCCAGUGCCUCCU
5836
CCCGCCGCcAGUGCCUCCUdTsdT
antis


 


382-401
5837
GCUCCGGGGGUGGCCCCAG
5838
GcuccGGGGGuGGccccAGdTsdT
sense


 


382-401
5839
CUGGGGCCACCCCCGGAGC
5840
CUGGGGCcACCCCCGGAGCdTsdT
antis


 


383-402
5841
CUCCGGGGGUGGCCCCAGC
5842
cuccGGGGGuGGccccAGcdTsdT
sense


 


383-402
5843
GCUGGGGCCACCCCCGGAG
5844
GCUGGGGCcACCCCCGGAGdTsdT
antis


 


395-414
5845
CCCCAGCGGCAGCGGCGGA
5846
ccccAGcGGcAGcGGcGGAdTsdT
sense


 


395-414
5847
UCCGCCGCUGCCGCUGGGG
5848
UCCGCCGCUGCCGCUGGGGdTsdT
antis


 


396-415
5849
CCCAGCGGCAGCGGCGGAG
5850
cccAGcGGcAGcGGcGGAGdTsdT
sense


 


396-415
5851
CUCCGCCGCUGCCGCUGGG
5852
CUCCGCCGCUGCCGCUGGGdTsdT
antis


 


397-416
5853
CCAGCGGCAGCGGCGGAGG
5854
ccAGcGGcAGcGGcGGAGGdTsdT
sense


 


397-416
5855
CCUCCGCCGCUGCCGCUGG
5856
CCUCCGCCGCUGCCGCUGGdTsdT
antis


 


398-417
5857
CAGCGGCAGCGGCGGAGGA
5858
cAGcGGcAGcGGcGGAGGAdTsdT
sense


 


398-417
5859
UCCUCCGCCGCUGCCGCUG
5860
UCCUCCGCCGCUGCCGCUGdTsdT
antis


 


400-419
5861
GCGGCAGCGGCGGAGGAGG
5862
GcGGcAGcGGcGGAGGAGGdTsdT
sense


 


400-419
5863
CCUCCUCCGCCGCUGCCGC
5864
CCUCCUCCGCCGCUGCCGCdTsdT
antis


 


405-424
5865
AGCGGCGGAGGAGGCAGCG
5866
AGcGGcGGAGGAGGcAGcGdTsdT
sense


 


405-424
5867
CGCUGCCUCCUCCGCCGCU
5868
CGCUGCCUCCUCCGCCGCUdTsdT
antis


 


406-425
5869
GCGGCGGAGGAGGCAGCGG
5870
GcGGcGGAGGAGGcAGcGGdTsdT
sense


 


406-425
5871
CCGCUGCCUCCUCCGCCGC
5872
CCGCUGCCUCCUCCGCCGCdTsdT
antis


 


407-426
5873
CGGCGGAGGAGGCAGCGGU
5874
cGGcGGAGGAGGcAGcGGudTsdT
sense


 


407-426
5875
ACCGCUGCCUCCUCCGCCG
5876
ACCGCUGCCUCCUCCGCCGdTsdT
antis


 


408-427
5877
GGCGGAGGAGGCAGCGGUG
5878
GGcGGAGGAGGcAGcGGuGdTsdT
sense


 


408-427
5879
CACCGCUGCCUCCUCCGCC
5880
cACCGCUGCCUCCUCCGCCdTsdT
antis


 


444-463
5881
AGCUUCCCGCCGCCGGGAG
5882
AGcuucccGccGccGGGAGdTsdT
sense


 


444-463
5883
CUCCCGGCGGCGGGAAGCU
5884
CUCCCGGCGGCGGGAAGCUdTsdT
antis


 


461-480
5885
AGUGAAGCUGGGCCGUGAC
5886
AGuGAAGcuGGGccGuGAcdTsdT
sense


 


461-480
5887
GUCACGGCCCAGCUUCACU
5888
GUcACGGCCcAGCUUcACUdTsdT
antis


 


493-512
5889
CCACAGUGGUAGCCACUGU
5890
ccAcAGuGGuAGccAcuGudTsdT
sense


 


493-512
5891
ACAGUGGCUACCACUGUGG
5892
AcAGUGGCuACcACUGUGGdTsdT
antis


 


513-532
5893
GGCCAAGGCCCAGAGCGUU
5894
GGccAAGGcccAGAGcGuudTsdT
sense


 


513-532
5895
AACGCUCUGGGCCUUGGCC
5896
AACGCUCUGGGCCUUGGCCdTsdT
antis


 


606-625
5897
GCAGAGACGAGGGAACUGG
5898
GcAGAGAcGAGGGAAcuGGdTsdT
sense


 


606-625
5899
CCAGUUCCCUCGUCUCUGC
5900
CcAGUUCCCUCGUCUCUGCdTsdT
antis


 


616-635
5901
GGGAACUGGUGGCCAUCAA
5902
GGGAAcuGGuGGccAucAAdTsdT
sense


 


616-635
5903
UUGAUGGCCACCAGUUCCC
5904
UUGAUGGCcACcAGUUCCCdTsdT
antis


 


620-639
5905
ACUGGUGGCCAUCAAGAAG
5906
AcuGGuGGccAucAAGAAGdTsdT
sense


 


620-639
5907
CUUCUUGAUGGCCACCAGU
5908
CUUCUUGAUGGCcACcAGUdTsdT
antis


 


621-640
5909
CUGGUGGCCAUCAAGAAGG
5910
cuGGuGGccAucAAGAAGGdTsdT
sense


 


621-640
5911
CCUUCUUGAUGGCCACCAG
5912
CCUUCUUGAUGGCcACcAGdTsdT
antis


 


711-730
5913
AGGCUGCGGUACUUUUUCU
5914
AGGcuGcGGuAcuuuuucudTsdT
sense


 


711-730
5915
AGAAAAAGUACCGCAGCCU
5916
AGAAAAAGuACCGcAGCCUdTsdT
antis


 


712-731
5917
GGCUGCGGUACUUUUUCUA
5918
GGcuGcGGuAcuuuuucuAdTsdT
sense


 


712-731
5919
UAGAAAAAGUACCGCAGCC
5920
uAGAAAAAGuACCGcAGCCdTsdT
antis


 


716-735
5921
GCGGUACUUUUUCUACUCC
5922
GcGGuAcuuuuucuAcuccdTsdT
sense


 


716-735
5923
GGAGUAGAAAAAGUACCGC
5924
GGAGuAGAAAAAGuACCGCdTsdT
antis


 


851-870
5925
CAUCAAGGUGUACAUGUAC
5926
cAucAAGGuGuAcAuGuAcdTsdT
sense


 


851-870
5927
GUACAUGUACACCUUGAUG
5928
GuAcAUGuAcACCUUGAUGdTsdT
antis


 


891-910
5929
UACAUCCACUCCCAAGGUG
5930
uAcAuccAcucccAAGGuGdTsdT
sense


 


891-910
5931
CACCUUGGGAGUGGAUGUA
5932
cACCUUGGGAGUGGAUGuAdTsdT
antis


 


948-967
5933
GACCCUGACACUGCUGUCC
5934
GAcccuGAcAcuGcuGuccdTsdT
sense


 


948-967
5935
GGACAGCAGUGUCAGGGUC
5936
GGAcAGcAGUGUcAGGGUCdTsdT
antis


 


951-970
5937
CCUGACACUGCUGUCCUCA
5938
ccuGAcAcuGcuGuccucAdTsdT
sense


 


951-970
5939
UGAGGACAGCAGUGUCAGG
5940
UGAGGAcAGcAGUGUcAGGdTsdT
antis


 


955-974
5941
ACACUGCUGUCCUCAAGCU
5942
AcAcuGcuGuccucAAGcudTsdT
sense


 


955-974
5943
AGCUUGAGGACAGCAGUGU
5944
AGCUUGAGGAcAGcAGUGUdTsdT
antis


 


956-975
5945
CACUGCUGUCCUCAAGCUC
5946
cAcuGcuGuccucAAGcucdTsdT
sense


 


956-975
5947
GAGCUUGAGGACAGCAGUG
5948
GAGCUUGAGGAcAGcAGUGdTsdT
antis


 


958-977
5949
CUGCUGUCCUCAAGCUCUG
5950
cuGcuGuccucAAGcucuGdTsdT
sense


 


958-977
5951
CAGAGCUUGAGGACAGCAG
5952
cAGAGCUUGAGGAcAGcAGdTsdT
antis


 


959-978
5953
UGCUGUCCUCAAGCUCUGC
5954
uGcuGuccucAAGcucuGcdTsdT
sense


 


959-978
5955
GCAGAGCUUGAGGACAGCA
5956
GcAGAGCUUGAGGAcAGcAdTsdT
antis


 


1028-1047
5957
CAUCUGCUCUCGGUACUAC
5958
cAucuGcucucGGuAcuAcdTsdT
sense


 


1028-1047
5959
GUAGUACCGAGAGCAGAUG
5960
GuAGuACCGAGAGcAGAUGdTsdT
antis


 


1052-1071
5961
UCCAGAACUCAUCUUUGGA
5962
uccAGAAcucAucuuuGGAdTsdT
sense


 


1052-1071
5963
UCCAAAGAUGAGUUCUGGA
5964
UCcAAAGAUGAGUUCUGGAdTsdT
antis


 


1084-1103
5965
CCUCGUCCAUCGAUGUGUG
5966
ccucGuccAucGAuGuGuGdTsdT
sense


 


1084-1103
5967
CACACAUCGAUGGACGAGG
5968
cAcAcAUCGAUGGACGAGGdTsdT
antis


 


1103-1122
5969
GUCGGCUGGCUGUGUACUU
5970
GucGGcuGGcuGuGuAcuudTsdT
sense


 


1103-1122
5971
AAGUACACAGCCAGCCGAC
5972
AAGuAcAcAGCcAGCCGACdTsdT
antis


 


1111-1130
5973
GCUGUGUACUUGCUGAGCU
5974
GcuGuGuAcuuGcuGAGcudTsdT
sense


 


1111-1130
5975
AGCUCAGCAAGUACACAGC
5976
AGCUcAGcAAGuAcAcAGCdTsdT
antis


 


1116-1135
5977
GUACUUGCUGAGCUACUUC
5978
GuAcuuGcuGAGcuAcuucdTsdT
sense


 


1116-1135
5979
GAAGUAGCUCAGCAAGUAC
5980
GAAGuAGCUcAGcAAGuACdTsdT
antis


 


1132-1151
5981
UUCUCGGCCAGCCCAUCUU
5982
uucucGGccAGcccAucuudTsdT
sense


 


1132-1151
5983
AAGAUGGGCUGGCCGAGAA
5984
AAGAUGGGCUGGCCGAGAAdTsdT
antis


 


1133-1152
5985
UCUCGGCCAGCCCAUCUUC
5986
ucucGGccAGcccAucuucdTsdT
sense


 


1133-1152
5987
GAAGAUGGGCUGGCCGAGA
5988
GAAGAUGGGCUGGCCGAGAdTsdT
antis


 


1136-1155
5989
CGGCCAGCCCAUCUUCCCU
5990
cGGccAGcccAucuucccudTsdT
sense


 


1136-1155
5991
AGGGAAGAUGGGCUGGCCG
5992
AGGGAAGAUGGGCUGGCCGdTsdT
antis


 


1143-1162
5993
CCCAUCUUCCCUGGGGACA
5994
cccAucuucccuGGGGAcAdTsdT
sense


 


1143-1162
5995
UGUCCCCAGGGAAGAUGGG
5996
UGUCCCcAGGGAAGAUGGGdTsdT
antis


 


1147-1166
5997
UCUUCCCUGGGGACAGUGG
5998
ucuucccuGGGGAcAGuGGdTsdT
sense


 


1147-1166
5999
CCACUGUCCCCAGGGAAGA
6000
CcACUGUCCCcAGGGAAGAdTsdT
antis


 


1152-1171
6001
CCUGGGGACAGUGGGGUGG
6002
ccuGGGGAcAGuGGGGuGGdTsdT
sense


 


1152-1171
6003
CCACCCCACUGUCCCCAGG
6004
CcACCCcACUGUCCCcAGGdTsdT
antis


 


1161-1180
6005
AGUGGGGUGGACCAGCUUG
6006
AGuGGGGuGGAccAGcuuGdTsdT
sense


 


1161-1180
6007
CAAGCUGGUCCACCCCACU
6008
cAAGCUGGUCcACCCcACUdTsdT
antis


 


1277-1296
6009
CCCUUGGACAAAGGUGUUC
6010
cccuuGGAcAAAGGuGuucdTsdT
sense


 


1277-1296
6011
GAACACCUUUGUCCAAGGG
6012
GAAcACCUUUGUCcAAGGGdTsdT
antis


 


1298-1317
6013
AUCUUCAAAGACACCACCU
6014
AucuucAAAGAcAccAccudTsdT
sense


 


1298-1317
6015
AGGUGGUGUCUUUGAAGAU
6016
AGGUGGUGUCUUUGAAGAUdTsdT
antis


 


1300-1319
6017
CUUCAAAGACACCACCUGA
6018
cuucAAAGAcAccAccuGAdTsdT
sense


 


1300-1319
6019
UCAGGUGGUGUCUUUGAAG
6020
UcAGGUGGUGUCUUUGAAGdTsdT
antis


 


1301-1320
6021
UUCAAAGACACCACCUGAG
6022
uucAAAGAcAccAccuGAGdTsdT
sense


 


1301-1320
6023
CUCAGGUGGUGUCUUUGAA
6024
CUcAGGUGGUGUCUUUGAAdTsdT
antis


 


1357-1376
6025
CAUCCUCAAGGCUCUCCCC
6026
cAuccucAAGGcucuccccdTsdT
sense


 


1357-1376
6027
GGGGAGAGCCUUGAGGAUG
6028
GGGGAGAGCCUUGAGGAUGdTsdT
antis


 


1390-1409
6029
CCCACAGCUUCUUCGAUGA
6030
cccAcAGcuucuucGAuGAdTsdT
sense


 


1390-1409
6031
UCAUCGAAGAAGCUGUGGG
6032
UcAUCGAAGAAGCUGUGGGdTsdT
antis


 


1419-1438
6033
CUCGGAGCCCAGCUCCCCA
6034
cucGGAGcccAGcuccccAdTsdT
sense


 


1419-1438
6035
UGGGGAGCUGGGCUCCGAG
6036
UGGGGAGCUGGGCUCCGAGdTsdT
antis


 


1421-1440
6037
CGGAGCCCAGCUCCCCAAC
6038
cGGAGcccAGcuccccAAcdTsdT
sense


 


1421-1440
6039
GUUGGGGAGCUGGGCUCCG
6040
GUUGGGGAGCUGGGCUCCGdTsdT
antis


 


1497-1516
6041
UCUCUCAAUGCCAUUCUCA
6042
ucucucAAuGccAuucucAdTsdT
sense


 


1497-1516
6043
UGAGAAUGGCAUUGAGAGA
6044
UGAGAAUGGcAUUGAGAGAdTsdT
antis


 


1500-1519
6045
CUCAAUGCCAUUCUCAUCC
6046
cucAAuGccAuucucAuccdTsdT
sense


 


1500-1519
6047
GGAUGAGAAUGGCAUUGAG
6048
GGAUGAGAAUGGcAUUGAGdTsdT
antis


 


1501-1520
6049
UCAAUGCCAUUCUCAUCCC
6050
ucAAuGccAuucucAucccdTsdT
sense


 


1501-1520
6051
GGGAUGAGAAUGGCAUUGA
6052
GGGAUGAGAAUGGcAUUGAdTsdT
antis


 


1540-1559
6053
CAGGCCCUGCUUCUCCCCU
6054
cAGGcccuGcuucuccccudTsdT
sense


 


1540-1559
6055
AGGGGAGAAGCAGGGCCUG
6056
AGGGGAGAAGcAGGGCCUGdTsdT
antis


 


1547-1566
6057
UGCUUCUCCCCUCACCACU
6058
uGcuucuccccucAccAcudTsdT
sense


 


1547-1566
6059
AGUGGUGAGGGGAGAAGCA
6060
AGUGGUGAGGGGAGAAGcAdTsdT
antis


 


1586-1605
6061
AGCUUUAACUGAAGCUCAG
6062
AGcuuuAAcuGAAGcucAGdTsdT
sense


 


1586-1605
6063
CUGAGCUUCAGUUAAAGCU
6064
CUGAGCUUcAGUuAAAGCUdTsdT
antis


 


1621-1640
6065
AGCCAUCUGAUGCCACAAC
6066
AGccAucuGAuGccAcAAcdTsdT
sense


 


1621-1640
6067
GUUGUGGCAUCAGAUGGCU
6068
GUUGUGGcAUcAGAUGGCUdTsdT
antis


 


1818-1837
6069
AGCCUAACCUCUGUGGUGG
6070
AGccuAAccucuGuGGuGGdTsdT
sense


 


1818-1837
6071
CCACCACAGAGGUUAGGCU
6072
CcACcAcAGAGGUuAGGCUdTsdT
antis


 


1865-1884
6073
UAGGGGAGGGGAGAAAAGG
6074
uAGGGGAGGGGAGAAAAGGdTsdT
sense


 


1865-1884
6075
CCUUUUCUCCCCUCCCCUA
6076
CCUUUUCUCCCCUCCCCuAdTsdT
antis


 


1866-1885
6077
AGGGGAGGGGAGAAAAGGA
6078
AGGGGAGGGGAGAAAAGGAdTsdT
sense


 


1866-1885
6079
UCCUUUUCUCCCCUCCCCU
6080
UCCUUUUCUCCCCUCCCCUdTsdT
antis


 


1867-1886
6081
GGGGAGGGGAGAAAAGGAA
6082
GGGGAGGGGAGAAAAGGAAdTsdT
sense


 


1867-1886
6083
UUCCUUUUCUCCCCUCCCC
6084
UUCCUUUUCUCCCCUCCCCdTsdT
antis


 


1868-1887
6085
GGGAGGGGAGAAAAGGAAG
6086
GGGAGGGGAGAAAAGGAAGdTsdT
sense


 


1868-1887
6087
CUUCCUUUUCUCCCCUCCC
6088
CUUCCUUUUCUCCCCUCCCdTsdT
antis


 


1872-1891
6089
GGGGAGAAAAGGAAGGACG
6090
GGGGAGAAAAGGAAGGAcGdTsdT
sense


 


1872-1891
6091
CGUCCUUCCUUUUCUCCCC
6092
CGUCCUUCCUUUUCUCCCCdTsdT
antis


 


1901-1920
6093
GUGUGAGGACCUUCUACCC
6094
GuGuGAGGAccuucuAcccdTsdT
sense


 


1901-1920
6095
GGGUAGAAGGUCCUCACAC
6096
GGGuAGAAGGUCCUcAcACdTsdT
antis


 


1929-1948
6097
CCUCCCCUCCCCCAGGCUA
6098
ccuccccucccccAGGcuAdTsdT
sense


 


1929-1948
6099
UAGCCUGGGGGAGGGGAGG
6100
uAGCCUGGGGGAGGGGAGGdTsdT
antis


 


1930-1949
6101
CUCCCCUCCCCCAGGCUAC
6102
cuccccucccccAGGcuAcdTsdT
sense


 


1930-1949
6103
GUAGCCUGGGGGAGGGGAG
6104
GuAGCCUGGGGGAGGGGAGdTsdT
antis


 


1947-1966
6105
ACCACUCCUUCCCUCCCCC
6106
AccAcuccuucccucccccdTsdT
sense


 


1947-1966
6107
GGGGGAGGGAAGGAGUGGU
6108
GGGGGAGGGAAGGAGUGGUdTsdT
antis


 


1948-1967
6109
CCACUCCUUCCCUCCCCCC
6110
ccAcuccuucccuccccccdTsdT
sense


 


1948-1967
6111
GGGGGGAGGGAAGGAGUGG
6112
GGGGGGAGGGAAGGAGUGGdTsdT
antis


 


1949-1968
6113
CACUCCUUCCCUCCCCCCC
6114
cAcuccuucccucccccccdTsdT
sense


 


1949-1968
6115
GGGGGGGAGGGAAGGAGUG
6116
GGGGGGGAGGGAAGGAGUGdTsdT
antis


 


1950-1969
6117
ACUCCUUCCCUCCCCCCCU
6118
AcuccuucccucccccccudTsdT
sense


 


1950-1969
6119
AGGGGGGGAGGGAAGGAGU
6120
AGGGGGGGAGGGAAGGAGUdTsdT
antis


 


1951-1970
6121
CUCCUUCCCUCCCCCCCUC
6122
cuccuucccucccccccucdTsdT
sense


 


1951-1970
6123
GAGGGGGGGAGGGAAGGAG
6124
GAGGGGGGGAGGGAAGGAGdTsdT
antis


 


1955-1974
6125
UUCCCUCCCCCCCUCUCCC
6126
uucccucccccccucucccdTsdT
sense


 


1955-1974
6127
GGGAGAGGGGGGGAGGGAA
6128
GGGAGAGGGGGGGAGGGAAdTsdT
antis


 


1956-1975
6129
UCCCUCCCCCCCUCUCCCA
6130
ucccucccccccucucccAdTsdT
sense


 


1956-1975
6131
UGGGAGAGGGGGGGAGGGA
6132
UGGGAGAGGGGGGGAGGGAdTsdT
antis


 


1965-1984
6133
CCCUCUCCCAGGUCCCUUG
6134
cccucucccAGGucccuuGdTsdT
sense


 


1965-1984
6135
CAAGGGACCUGGGAGAGGG
6136
cAAGGGACCUGGGAGAGGGdTsdT
antis


 


1971-1990
6137
CCCAGGUCCCUUGUAAAUA
6138
cccAGGucccuuGuAAAuAdTsdT
sense


 


1971-1990
6139
UAUUUACAAGGGACCUGGG
6140
uAUUuAcAAGGGACCUGGGdTsdT
antis


 


1988-2007
6141
UAGAACCAGCCCAGCCCAU
6142
uAGAAccAGcccAGcccAudTsdT
sense


 


1988-2007
6143
AUGGGCUGGGCUGGUUCUA
6144
AUGGGCUGGGCUGGUUCuAdTsdT
antis


 


2005-2024
6145
AUCUCUCGUCUUCCCUUCC
6146
AucucucGucuucccuuccdTsdT
sense


 


2005-2024
6147
GGAAGGGAAGACGAGAGAU
6148
GGAAGGGAAGACGAGAGAUdTsdT
antis


 


2006-2025
6149
UCUCUCGUCUUCCCUUCCC
6150
ucucucGucuucccuucccdTsdT
sense


 


2006-2025
6151
GGGAAGGGAAGACGAGAGA
6152
GGGAAGGGAAGACGAGAGAdTsdT
antis


 


2020-2039
6153
UUCCCUGGCCCCCUGGGUG
6154
uucccuGGcccccuGGGuGdTsdT
sense


 


2020-2039
6155
CACCCAGGGGGCCAGGGAA
6156
cACCcAGGGGGCcAGGGAAdTsdT
antis


 


2039-2058
6157
UAAAUAGAUUGUUAUAAUU
6158
uAAAuAGAuuGuuAuAAuudTsdT
sense


 


2039-2058
6159
AAUUAUAACAAUCUAUUUA
6160
AAUuAuAAcAAUCuAUUuAdTsdT
antis


 


2050-2069
6161
UUAUAAUUUUUUCUUAAAG
6162
uuAuAAuuuuuucuuAAAGdTsdT
sense


 


2050-2069
6163
CUUUAAGAAAAAAUUAUAA
6164
CUUuAAGAAAAAAUuAuAAdTsdT
antis


 


2052-2071
6165
AUAAUUUUUUCUUAAAGAA
6166
AuAAuuuuuucuuAAAGAAdTsdT
sense


 


2052-2071
6167
UUCUUUAAGAAAAAAUUAU
6168
UUCUUuAAGAAAAAAUuAUdTsdT
antis


 


2053-2072
6169
UAAUUUUUUCUUAAAGAAA
6170
uAAuuuuuucuuAAAGAAAdTsdT
sense


 


2053-2072
6171
UUUCUUUAAGAAAAAAUUA
6172
UUUCUUuAAGAAAAAAUuAdTsdT
antis


 


2054-2073
6173
AAUUUUUUCUUAAAGAAAA
6174
AAuuuuuucuuAAAGAAAAdTsdT
sense


 


2054-2073
6175
UUUUCUUUAAGAAAAAAUU
6176
UUUUCUUuAAGAAAAAAUUdTsdT
antis


 


2110-2129
6177
UACCCCUUCUUGUCCUCUG
6178
uAccccuucuuGuccucuGdTsdT
sense


 


2110-2129
6179
CAGAGGACAAGAAGGGGUA
6180
cAGAGGAcAAGAAGGGGuAdTsdT
antis


 


2112-2131
6181
CCCCUUCUUGUCCUCUGCU
6182
ccccuucuuGuccucuGcudTsdT
sense


 


2112-2131
6183
AGCAGAGGACAAGAAGGGG
6184
AGcAGAGGAcAAGAAGGGGdTsdT
antis


 


2113-2132
6185
CCCUUCUUGUCCUCUGCUC
6186
cccuucuuGuccucuGcucdTsdT
sense


 


2113-2132
6187
GAGCAGAGGACAAGAAGGG
6188
GAGcAGAGGAcAAGAAGGGdTsdT
antis


 


2114-2133
6189
CCUUCUUGUCCUCUGCUCC
6190
ccuucuuGuccucuGcuccdTsdT
sense


 


2114-2133
6191
GGAGCAGAGGACAAGAAGG
6192
GGAGcAGAGGAcAAGAAGGdTsdT
antis


 


2115-2134
6193
CUUCUUGUCCUCUGCUCCC
6194
cuucuuGuccucuGcucccdTsdT
sense


 


2115-2134
6195
GGGAGCAGAGGACAAGAAG
6196
GGGAGcAGAGGAcAAGAAGdTsdT
antis


 


2126-2145
6197
CUGCUCCCAAGGCUUCCUC
6198
cuGcucccAAGGcuuccucdTsdT
sense


 


2126-2145
6199
GAGGAAGCCUUGGGAGCAG
6200
GAGGAAGCCUUGGGAGcAGdTsdT
antis


 


2131-2150
6201
CCCAAGGCUUCCUCCCUCU
6202
cccAAGGcuuccucccucudTsdT
sense


 


2131-2150
6203
AGAGGGAGGAAGCCUUGGG
6204
AGAGGGAGGAAGCCUUGGGdTsdT
antis


 


2137-2156
6205
GCUUCCUCCCUCUCCCCAU
6206
GcuuccucccucuccccAudTsdT
sense


 


2137-2156
6207
AUGGGGAGAGGGAGGAAGC
6208
AUGGGGAGAGGGAGGAAGCdTsdT
antis


 


2138-2157
6209
CUUCCUCCCUCUCCCCAUC
6210
cuuccucccucuccccAucdTsdT
sense


 


2138-2157
6211
GAUGGGGAGAGGGAGGAAG
6212
GAUGGGGAGAGGGAGGAAGdTsdT
antis


 


2140-2159
6213
UCCUCCCUCUCCCCAUCCU
6214
uccucccucuccccAuccudTsdT
sense


 


2140-2159
6215
AGGAUGGGGAGAGGGAGGA
6216
AGGAUGGGGAGAGGGAGGAdTsdT
antis


 


2141-2160
6217
CCUCCCUCUCCCCAUCCUG
6218
ccucccucuccccAuccuGdTsdT
sense


 


2141-2160
6219
CAGGAUGGGGAGAGGGAGG
6220
cAGGAUGGGGAGAGGGAGGdTsdT
antis


 


2145-2164
6221
CCUCUCCCCAUCCUGGAAG
6222
ccucuccccAuccuGGAAGdTsdT
sense


 


2145-2164
6223
CUUCCAGGAUGGGGAGAGG
6224
CUUCcAGGAUGGGGAGAGGdTsdT
antis


 


2153-2172
6225
CAUCCUGGAAGGAGGGGAG
6226
cAuccuGGAAGGAGGGGAGdTsdT
sense


 


2153-2172
6227
CUCCCCUCCUUCCAGGAUG
6228
CUCCCCUCCUUCcAGGAUGdTsdT
antis


 


2172-2191
6229
UAGAGAGAGUCCCUGGUGU
6230
uAGAGAGAGucccuGGuGudTsdT
sense


 


2172-2191
6231
ACACCAGGGACUCUCUCUA
6232
AcACcAGGGACUCUCUCuAdTsdT
antis


 


2186-2205
6233
GGUGUCUUAGUUUCCACAG
6234
GGuGucuuAGuuuccAcAGdTsdT
sense


 


2186-2205
6235
CUGUGGAAACUAAGACACC
6236
CUGUGGAAACuAAGAcACCdTsdT
antis


 


2193-2212
6237
UAGUUUCCACAGUAAGGUU
6238
uAGuuuccAcAGuAAGGuudTsdT
sense


 


2193-2212
6239
AACCUUACUGUGGAAACUA
6240
AACCUuACUGUGGAAACuAdTsdT
antis


 


2240-2259
6241
AUUAUUGGCAUGAAACCCU
6242
AuuAuuGGcAuGAAAcccudTsdT
sense


 


2240-2259
6243
AGGGUUUCAUGCCAAUAAU
6244
AGGGUUUcAUGCcAAuAAUdTsdT
antis


 


62-81
6245
CUGGGCCGGAGCCGGAGCC
6246
cuGGGccGGAGccGGAGccdTsdT
sense


 


62-81
6247
GGCUCCGGCUCCGGCCCAG
6248
GGCUCCGGCUCCGGCCcAGdTsdT
antis


 


120-139
6249
GCGGCGGCAGAGGCAGCGG
6250
GcGGcGGcAGAGGcAGcGGdTsdT
sense


 


120-139
6251
CCGCUGCCUCUGCCGCCGC
6252
CCGCUGCCUCUGCCGCCGCdTsdT
antis


 


121-140
6253
CGGCGGCAGAGGCAGCGGC
6254
cGGcGGcAGAGGcAGcGGcdTsdT
sense


 


121-140
6255
GCCGCUGCCUCUGCCGCCG
6256
GCCGCUGCCUCUGCCGCCGdTsdT
antis


 


127-146
6257
CAGAGGCAGCGGCGGGGGC
6258
cAGAGGcAGcGGcGGGGGcdTsdT
sense


 


127-146
6259
GCCCCCGCCGCUGCCUCUG
6260
GCCCCCGCCGCUGCCUCUGdTsdT
antis


 


142-161
6261
GGGCAGCCCAGGCAGCCCG
6262
GGGcAGcccAGGcAGcccGdTsdT
sense


 


142-161
6263
CGGGCUGCCUGGGCUGCCC
6264
CGGGCUGCCUGGGCUGCCCdTsdT
antis


 


267-286
6265
GGAGGCGGAGGCGGAGGUG
6266
GGAGGcGGAGGcGGAGGuGdTsdT
sense


 


267-286
6267
CACCUCCGCCUCCGCCUCC
6268
cACCUCCGCCUCCGCCUCCdTsdT
antis


 


268-287
6269
GAGGCGGAGGCGGAGGUGG
6270
GAGGcGGAGGcGGAGGuGGdTsdT
sense


 


268-287
6271
CCACCUCCGCCUCCGCCUC
6272
CcACCUCCGCCUCCGCCUCdTsdT
antis


 


271-290
6273
GCGGAGGCGGAGGUGGUGG
6274
GcGGAGGcGGAGGuGGuGGdTsdT
sense


 


271-290
6275
CCACCACCUCCGCCUCCGC
6276
CcACcACCUCCGCCUCCGCdTsdT
antis


 


284-303
6277
UGGUGGCGGCGGCCCCGGG
6278
uGGuGGcGGcGGccccGGGdTsdT
sense


 


284-303
6279
CCCGGGGCCGCCGCCACCA
6280
CCCGGGGCCGCCGCcACcAdTsdT
antis


 


591-610
6281
UACCAGGCACGGCUGGCAG
6282
uAccAGGcAcGGcuGGcAGdTsdT
sense


 


591-610
6283
CUGCCAGCCGUGCCUGGUA
6284
CUGCcAGCCGUGCCUGGuAdTsdT
antis


 


1131-1150
6285
CUUCUCGGCCAGCCCAUCU
6286
cuucucGGccAGcccAucudTsdT
sense


 


1131-1150
6287
AGAUGGGCUGGCCGAGAAG
6288
AGAUGGGCUGGCCGAGAAGdTsdT
antis


 


1299-1318
6289
UCUUCAAAGACACCACCUG
6290
ucuucAAAGAcAccAccuGdTsdT
sense


 


1299-1318
6291
CAGGUGGUGUCUUUGAAGA
6292
cAGGUGGUGUCUUUGAAGAdTsdT
antis


 


1558-1577
6293
UCACCACUUCCUACAACCC
6294
ucAccAcuuccuAcAAcccdTsdT
sense


 


1558-1577
6295
GGGUUGUAGGAAGUGGUGA
6296
GGGUUGuAGGAAGUGGUGAdTsdT
antis


 


1927-1946
6297
CCCCUCCCCUCCCCCAGGC
6298
ccccuccccucccccAGGcdTsdT
sense


 


1927-1946
6299
GCCUGGGGGAGGGGAGGGG
6300
GCCUGGGGGAGGGGAGGGGdTsdT
antis


 


1928-1947
6301
CCCUCCCCUCCCCCAGGCU
6302
cccuccccucccccAGGcudTsdT
sense


 


1928-1947
6303
AGCCUGGGGGAGGGGAGGG
6304
AGCCUGGGGGAGGGGAGGGdTsdT
antis


 


2111-2130
6305
ACCCCUUCUUGUCCUCUGC
6306
AccccuucuuGuccucuGcdTsdT
sense


 


2111-2130
6307
GCAGAGGACAAGAAGGGGU
6308
GcAGAGGAcAAGAAGGGGUdTsdT
antis


 


2142-2161
6309
CUCCCUCUCCCCAUCCUGG
6310
cucccucuccccAuccuGGdTsdT
sense


 


2142-2161
6311
CCAGGAUGGGGAGAGGGAG
6312
CcAGGAUGGGGAGAGGGAGdTsdT
antis


 


2144-2163
6313
CCCUCUCCCCAUCCUGGAA
6314
cccucuccccAuccuGGAAdTsdT
sense


 


2144-2163
6315
UUCCAGGAUGGGGAGAGGG
6316
UUCcAGGAUGGGGAGAGGGdTsdT
antis


 


1671-1690
6317
CACCGACUACCCCUCCACG
6318
cAccGAcuAccccuccAcGdTsdT
sense


 


1671-1690
6319
CGUGGAGGGGUAGUCGGUG
6320
CGUGGAGGGGuAGUCGGUGdTsdT
antis


 


1673-1692
6321
CCGACUACCCCUCCACGUC
6322
ccGAcuAccccuccAcGucdTsdT
sense


 


1673-1692
6323
GACGUGGAGGGGUAGUCGG
6324
GACGUGGAGGGGuAGUCGGdTsdT
antis


 


1036-1055
6325
CUCGGUACUACCGUGCUCC
6326
cucGGuAcuAccGuGcuccdTsdT
sense


 


1036-1055
6327
GGAGCACGGUAGUACCGAG
6328
GGAGcACGGuAGuACCGAGdTsdT
antis


 


1035-1054
6329
UCUCGGUACUACCGUGCUC
6330
ucucGGuAcuAccGuGcucdTsdT
sense


 


1035-1054
6331
GAGCACGGUAGUACCGAGA
6332
GAGcACGGuAGuACCGAGAdTsdT
antis


 


1042-1061
6333
ACUACCGUGCUCCAGAACU
6334
AcuAccGuGcuccAGAAcudTsdT
sense


 


1042-1061
6335
AGUUCUGGAGCACGGUAGU
6336
AGUUCUGGAGcACGGuAGUdTsdT
antis


 


1674-1693
6337
CGACUACCCCUCCACGUCC
6338
cGAcuAccccuccAcGuccdTsdT
sense


 


1674-1693
6339
GGACGUGGAGGGGUAGUCG
6340
GGACGUGGAGGGGuAGUCGdTsdT
antis


 


1787-1806
6341
AACUACCCCCAGCAUCUAG
6342
AAcuAcccccAGcAucuAGdTsdT
sense


 


1787-1806
6343
CUAGAUGCUGGGGGUAGUU
6344
CuAGAUGCUGGGGGuAGUUdTsdT
antis


 


1034-1053
6345
CUCUCGGUACUACCGUGCU
6346
cucucGGuAcuAccGuGcudTsdT
sense


 


1034-1053
6347
AGCACGGUAGUACCGAGAG
6348
AGcACGGuAGuACCGAGAGdTsdT
antis


 


1202-1221
6349
AACGCCAACCAGGGAACAA
6350
AAcGccAAccAGGGAAcAAdTsdT
sense


 


1202-1221
6351
UUGUUCCCUGGUUGGCGUU
6352
UUGUUCCCUGGUUGGCGUUdTsdT
antis


 


776-795
6353
GGAGUAUGUGCCCGAGACG
6354
GGAGuAuGuGcccGAGAcGdTsdT
sense


 


776-795
6355
CGUCUCGGGCACAUACUCC
6356
CGUCUCGGGcAcAuACUCCdTsdT
antis


 


779-798
6357
GUAUGUGCCCGAGACGGUG
6358
GuAuGuGcccGAGAcGGuGdTsdT
sense


 


779-798
6359
CACCGUCUCGGGCACAUAC
6360
cACCGUCUCGGGcAcAuACdTsdT
antis


 


780-799
6361
UAUGUGCCCGAGACGGUGU
6362
uAuGuGcccGAGAcGGuGudTsdT
sense


 


780-799
6363
ACACCGUCUCGGGCACAUA
6364
AcACCGUCUCGGGcAcAuAdTsdT
antis


 


973-992
6365
UCUGCGAUUUUGGCAGUGC
6366
ucuGcGAuuuuGGcAGuGcdTsdT
sense


 


973-992
6367
GCACUGCCAAAAUCGCAGA
6368
GcACUGCcAAAAUCGcAGAdTsdT
antis


 


1038-1057
6369
CGGUACUACCGUGCUCCAG
6370
cGGuAcuAccGuGcuccAGdTsdT
sense


 


1038-1057
6371
CUGGAGCACGGUAGUACCG
6372
CUGGAGcACGGuAGuACCGdTsdT
antis


 


1041-1060
6373
UACUACCGUGCUCCAGAAC
6374
uAcuAccGuGcuccAGAAcdTsdT
sense


 


1041-1060
6375
GUUCUGGAGCACGGUAGUA
6376
GUUCUGGAGcACGGuAGuAdTsdT
antis


 


1043-1062
6377
CUACCGUGCUCCAGAACUC
6378
cuAccGuGcuccAGAAcucdTsdT
sense


 


1043-1062
6379
GAGUUCUGGAGCACGGUAG
6380
GAGUUCUGGAGcACGGuAGdTsdT
antis


 


1189-1208
6381
UCAAGGUACUAGGAACGCC
6382
ucAAGGuAcuAGGAAcGccdTsdT
sense


 


1189-1208
6383
GGCGUUCCUAGUACCUUGA
6384
GGCGUUCCuAGuACCUUGAdTsdT
antis


 


1190-1209
6385
CAAGGUACUAGGAACGCCA
6386
cAAGGuAcuAGGAAcGccAdTsdT
sense


 


1190-1209
6387
UGGCGUUCCUAGUACCUUG
6388
UGGCGUUCCuAGuACCUUGdTsdT
antis


 


1191-1210
6389
AAGGUACUAGGAACGCCAA
6390
AAGGuAcuAGGAAcGccAAdTsdT
sense


 


1191-1210
6391
UUGGCGUUCCUAGUACCUU
6392
UUGGCGUUCCuAGuACCUUdTsdT
antis


 


1192-1211
6393
AGGUACUAGGAACGCCAAC
6394
AGGuAcuAGGAAcGccAAcdTsdT
sense


 


1192-1211
6395
GUUGGCGUUCCUAGUACCU
6396
GUUGGCGUUCCuAGuACCUdTsdT
antis


 


1197-1216
6397
CUAGGAACGCCAACCAGGG
6398
cuAGGAAcGccAAccAGGGdTsdT
sense


 


1197-1216
6399
CCCUGGUUGGCGUUCCUAG
6400
CCCUGGUUGGCGUUCCuAGdTsdT
antis


 


1203-1222
6401
ACGCCAACCAGGGAACAAA
6402
AcGccAAccAGGGAAcAAAdTsdT
sense


 


1203-1222
6403
UUUGUUCCCUGGUUGGCGU
6404
UUUGUUCCCUGGUUGGCGUdTsdT
antis


 


1670-1689
6405
CCACCGACUACCCCUCCAC
6406
ccAccGAcuAccccuccAcdTsdT
sense


 


1670-1689
6407
GUGGAGGGGUAGUCGGUGG
6408
GUGGAGGGGuAGUCGGUGGdTsdT
antis


 


1672-1691
6409
ACCGACUACCCCUCCACGU
6410
AccGAcuAccccuccAcGudTsdT
sense


 


1672-1691
6411
ACGUGGAGGGGUAGUCGGU
6412
ACGUGGAGGGGuAGUCGGUdTsdT
antis


 


1780-1799
6413
GUAAAUGAACUACCCCCAG
6414
GuAAAuGAAcuAcccccAGdTsdT
sense


 


1780-1799
6415
CUGGGGGUAGUUCAUUUAC
6416
CUGGGGGuAGUUcAUUuACdTsdT
antis


 


1786-1805
6417
GAACUACCCCCAGCAUCUA
6418
GAAcuAcccccAGcAucuAdTsdT
sense


 


1786-1805
6419
UAGAUGCUGGGGGUAGUUC
6420
uAGAUGCUGGGGGuAGUUCdTsdT
antis


 


352-371
6421
GGGCUAUGGGUGGGGGCGU
6422
GGGcuAuGGGuGGGGGcGudTsdT
sense


 


352-371
6423
ACGCCCCCACCCAUAGCCC
6424
ACGCCCCcACCcAuAGCCCdTsdT
antis


 


354-373
6425
GCUAUGGGUGGGGGCGUGG
6426
GcuAuGGGuGGGGGcGuGGdTsdT
sense


 


354-373
6427
CCACGCCCCCACCCAUAGC
6428
CcACGCCCCcACCcAuAGCdTsdT
antis


 


521-540
6429
CCCAGAGCGUUCCCAAGAA
6430
cccAGAGcGuucccAAGAAdTsdT
sense


 


521-540
6431
UUCUUGGGAACGCUCUGGG
6432
UUCUUGGGAACGCUCUGGGdTsdT
antis


 


523-542
6433
CAGAGCGUUCCCAAGAAGU
6434
cAGAGcGuucccAAGAAGudTsdT
sense


 


523-542
6435
ACUUCUUGGGAACGCUCUG
6436
ACUUCUUGGGAACGCUCUGdTsdT
antis


 


524-543
6437
AGAGCGUUCCCAAGAAGUG
6438
AGAGcGuucccAAGAAGuGdTsdT
sense


 


524-543
6439
CACUUCUUGGGAACGCUCU
6440
cACUUCUUGGGAACGCUCUdTsdT
antis


 


527-546
6441
GCGUUCCCAAGAAGUGGCU
6442
GcGuucccAAGAAGuGGcudTsdT
sense


 


527-546
6443
AGCCACUUCUUGGGAACGC
6444
AGCcACUUCUUGGGAACGCdTsdT
antis


 


550-569
6445
CUGACAUCAAAGUGAUUGG
6446
cuGAcAucAAAGuGAuuGGdTsdT
sense


 


550-569
6447
CCAAUCACUUUGAUGUCAG
6448
CcAAUcACUUUGAUGUcAGdTsdT
antis


 


568-587
6449
GUAAUGGCUCAUUCGGAGU
6450
GuAAuGGcucAuucGGAGudTsdT
sense


 


568-587
6451
ACUCCGAAUGAGCCAUUAC
6452
ACUCCGAAUGAGCcAUuACdTsdT
antis


 


569-588
6453
UAAUGGCUCAUUCGGAGUA
6454
uAAuGGcucAuucGGAGuAdTsdT
sense


 


569-588
6455
UACUCCGAAUGAGCCAUUA
6456
uACUCCGAAUGAGCcAUuAdTsdT
antis


 


570-589
6457
AAUGGCUCAUUCGGAGUAG
6458
AAuGGcucAuucGGAGuAGdTsdT
sense


 


570-589
6459
CUACUCCGAAUGAGCCAUU
6460
CuACUCCGAAUGAGCcAUUdTsdT
antis


 


572-591
6461
UGGCUCAUUCGGAGUAGUA
6462
uGGcucAuucGGAGuAGuAdTsdT
sense


 


572-591
6463
UACUACUCCGAAUGAGCCA
6464
uACuACUCCGAAUGAGCcAdTsdT
antis


 


626-645
6465
GGCCAUCAAGAAGGUUCUU
6466
GGccAucAAGAAGGuucuudTsdT
sense


 


626-645
6467
AAGAACCUUCUUGAUGGCC
6468
AAGAACCUUCUUGAUGGCCdTsdT
antis


 


688-707
6469
AGCUGGACCACUGCAAUAU
6470
AGcuGGAccAcuGcAAuAudTsdT
sense


 


688-707
6471
AUAUUGCAGUGGUCCAGCU
6472
AuAUUGcAGUGGUCcAGCUdTsdT
antis


 


693-712
6473
GACCACUGCAAUAUUGUGA
6474
GAccAcuGcAAuAuuGuGAdTsdT
sense


 


693-712
6475
UCACAAUAUUGCAGUGGUC
6476
UcAcAAuAUUGcAGUGGUCdTsdT
antis


 


697-716
6477
ACUGCAAUAUUGUGAGGCU
6478
AcuGcAAuAuuGuGAGGcudTsdT
sense


 


697-716
6479
AGCCUCACAAUAUUGCAGU
6480
AGCCUcAcAAuAUUGcAGUdTsdT
antis


 


724-743
6481
UUUUCUACUCCAGUGGGGA
6482
uuuucuAcuccAGuGGGGAdTsdT
sense


 


724-743
6483
UCCCCACUGGAGUAGAAAA
6484
UCCCcACUGGAGuAGAAAAdTsdT
antis


 


725-744
6485
UUUCUACUCCAGUGGGGAG
6486
uuucuAcuccAGuGGGGAGdTsdT
sense


 


725-744
6487
CUCCCCACUGGAGUAGAAA
6488
CUCCCcACUGGAGuAGAAAdTsdT
antis


 


726-745
6489
UUCUACUCCAGUGGGGAGA
6490
uucuAcuccAGuGGGGAGAdTsdT
sense


 


726-745
6491
UCUCCCCACUGGAGUAGAA
6492
UCUCCCcACUGGAGuAGAAdTsdT
antis


 


727-746
6493
UCUACUCCAGUGGGGAGAA
6494
ucuAcuccAGuGGGGAGAAdTsdT
sense


 


727-746
6495
UUCUCCCCACUGGAGUAGA
6496
UUCUCCCcACUGGAGuAGAdTsdT
antis


 


757-776
6497
UGUAUUUGAAUCUGGUGCU
6498
uGuAuuuGAAucuGGuGcudTsdT
sense


 


757-776
6499
AGCACCAGAUUCAAAUACA
6500
AGcACcAGAUUcAAAuAcAdTsdT
antis


 


759-778
6501
UAUUUGAAUCUGGUGCUGG
6502
uAuuuGAAucuGGuGcuGGdTsdT
sense


 


759-778
6503
CCAGCACCAGAUUCAAAUA
6504
CcAGcACcAGAUUcAAAuAdTsdT
antis


 


760-779
6505
AUUUGAAUCUGGUGCUGGA
6506
AuuuGAAucuGGuGcuGGAdTsdT
sense


 


760-779
6507
UCCAGCACCAGAUUCAAAU
6508
UCcAGcACcAGAUUcAAAUdTsdT
antis


 


762-781
6509
UUGAAUCUGGUGCUGGAGU
6510
uuGAAucuGGuGcuGGAGudTsdT
sense


 


762-781
6511
ACUCCAGCACCAGAUUCAA
6512
ACUCcAGcACcAGAUUcAAdTsdT
antis


 


763-782
6513
UGAAUCUGGUGCUGGAGUA
6514
uGAAucuGGuGcuGGAGuAdTsdT
sense


 


763-782
6515
UACUCCAGCACCAGAUUCA
6516
uACUCcAGcACcAGAUUcAdTsdT
antis


 


775-794
6517
UGGAGUAUGUGCCCGAGAC
6518
uGGAGuAuGuGcccGAGAcdTsdT
sense


 


775-794
6519
GUCUCGGGCACAUACUCCA
6520
GUCUCGGGcAcAuACUCcAdTsdT
antis


 


778-797
6521
AGUAUGUGCCCGAGACGGU
6522
AGuAuGuGcccGAGAcGGudTsdT
sense


 


778-797
6523
ACCGUCUCGGGCACAUACU
6524
ACCGUCUCGGGcAcAuACUdTsdT
antis


 


854-873
6525
CAAGGUGUACAUGUACCAG
6526
cAAGGuGuAcAuGuAccAGdTsdT
sense


 


854-873
6527
CUGGUACAUGUACACCUUG
6528
CUGGuAcAUGuAcACCUUGdTsdT
antis


 


855-874
6529
AAGGUGUACAUGUACCAGC
6530
AAGGuGuAcAuGuAccAGcdTsdT
sense


 


855-874
6531
GCUGGUACAUGUACACCUU
6532
GCUGGuAcAUGuAcACCUUdTsdT
antis


 


856-875
6533
AGGUGUACAUGUACCAGCU
6534
AGGuGuAcAuGuAccAGcudTsdT
sense


 


856-875
6535
AGCUGGUACAUGUACACCU
6536
AGCUGGuAcAUGuAcACCUdTsdT
antis


 


857-876
6537
GGUGUACAUGUACCAGCUC
6538
GGuGuAcAuGuAccAGcucdTsdT
sense


 


857-876
6539
GAGCUGGUACAUGUACACC
6540
GAGCUGGuAcAUGuAcACCdTsdT
antis


 


915-934
6541
CACCGUGACAUCAAGCCCC
6542
cAccGuGAcAucAAGccccdTsdT
sense


 


915-934
6543
GGGGCUUGAUGUCACGGUG
6544
GGGGCUUGAUGUcACGGUGdTsdT
antis


 


938-957
6545
UUUGCUUGUGGACCCUGAC
6546
uuuGcuuGuGGAcccuGAcdTsdT
sense


 


938-957
6547
GUCAGGGUCCACAAGCAAA
6548
GUcAGGGUCcAcAAGcAAAdTsdT
antis


 


945-964
6549
GUGGACCCUGACACUGCUG
6550
GuGGAcccuGAcAcuGcuGdTsdT
sense


 


945-964
6551
CAGCAGUGUCAGGGUCCAC
6552
cAGcAGUGUcAGGGUCcACdTsdT
antis


 


971-990
6553
GCUCUGCGAUUUUGGCAGU
6554
GcucuGcGAuuuuGGcAGudTsdT
sense


 


971-990
6555
ACUGCCAAAAUCGCAGAGC
6556
ACUGCcAAAAUCGcAGAGCdTsdT
antis


 


972-991
6557
CUCUGCGAUUUUGGCAGUG
6558
cucuGcGAuuuuGGcAGuGdTsdT
sense


 


972-991
6559
CACUGCCAAAAUCGCAGAG
6560
cACUGCcAAAAUCGcAGAGdTsdT
antis


 


975-994
6561
UGCGAUUUUGGCAGUGCAA
6562
uGcGAuuuuGGcAGuGcAAdTsdT
sense


 


975-994
6563
UUGCACUGCCAAAAUCGCA
6564
UUGcACUGCcAAAAUCGcAdTsdT
antis


 


979-998
6565
AUUUUGGCAGUGCAAAGCA
6566
AuuuuGGcAGuGcAAAGcAdTsdT
sense


 


979-998
6567
UGCUUUGCACUGCCAAAAU
6568
UGCUUUGcACUGCcAAAAUdTsdT
antis


 


1037-1056
6569
UCGGUACUACCGUGCUCCA
6570
ucGGuAcuAccGuGcuccAdTsdT
sense


 


1037-1056
6571
UGGAGCACGGUAGUACCGA
6572
UGGAGcACGGuAGuACCGAdTsdT
antis


 


1040-1059
6573
GUACUACCGUGCUCCAGAA
6574
GuAcuAccGuGcuccAGAAdTsdT
sense


 


1040-1059
6575
UUCUGGAGCACGGUAGUAC
6576
UUCUGGAGcACGGuAGuACdTsdT
antis


 


1169-1188
6577
GGACCAGCUUGUGGAGAUC
6578
GGAccAGcuuGuGGAGAucdTsdT
sense


 


1169-1188
6579
GAUCUCCACAAGCUGGUCC
6580
GAUCUCcAcAAGCUGGUCCdTsdT
antis


 


1174-1193
6581
AGCUUGUGGAGAUCAUCAA
6582
AGcuuGuGGAGAucAucAAdTsdT
sense


 


1174-1193
6583
UUGAUGAUCUCCACAAGCU
6584
UUGAUGAUCUCcAcAAGCUdTsdT
antis


 


1178-1197
6585
UGUGGAGAUCAUCAAGGUA
6586
uGuGGAGAucAucAAGGuAdTsdT
sense


 


1178-1197
6587
UACCUUGAUGAUCUCCACA
6588
uACCUUGAUGAUCUCcAcAdTsdT
antis


 


1183-1202
6589
AGAUCAUCAAGGUACUAGG
6590
AGAucAucAAGGuAcuAGGdTsdT
sense


 


1183-1202
6591
CCUAGUACCUUGAUGAUCU
6592
CCuAGuACCUUGAUGAUCUdTsdT
antis


 


1193-1212
6593
GGUACUAGGAACGCCAACC
6594
GGuAcuAGGAAcGccAAccdTsdT
sense


 


1193-1212
6595
GGUUGGCGUUCCUAGUACC
6596
GGUUGGCGUUCCuAGuACCdTsdT
antis


 


1194-1213
6597
GUACUAGGAACGCCAACCA
6598
GuAcuAGGAAcGccAAccAdTsdT
sense


 


1194-1213
6599
UGGUUGGCGUUCCUAGUAC
6600
UGGUUGGCGUUCCuAGuACdTsdT
antis


 


1195-1214
6601
UACUAGGAACGCCAACCAG
6602
uAcuAGGAAcGccAAccAGdTsdT
sense


 


1195-1214
6603
CUGGUUGGCGUUCCUAGUA
6604
CUGGUUGGCGUUCCuAGuAdTsdT
antis


 


1198-1217
6605
UAGGAACGCCAACCAGGGA
6606
uAGGAAcGccAAccAGGGAdTsdT
sense


 


1198-1217
6607
UCCCUGGUUGGCGUUCCUA
6608
UCCCUGGUUGGCGUUCCuAdTsdT
antis


 


1199-1218
6609
AGGAACGCCAACCAGGGAA
6610
AGGAAcGccAAccAGGGAAdTsdT
sense


 


1199-1218
6611
UUCCCUGGUUGGCGUUCCU
6612
UUCCCUGGUUGGCGUUCCUdTsdT
antis


 


1200-1219
6613
GGAACGCCAACCAGGGAAC
6614
GGAAcGccAAccAGGGAAcdTsdT
sense


 


1200-1219
6615
GUUCCCUGGUUGGCGUUCC
6616
GUUCCCUGGUUGGCGUUCCdTsdT
antis


 


1201-1220
6617
GAACGCCAACCAGGGAACA
6618
GAAcGccAAccAGGGAAcAdTsdT
sense


 


1201-1220
6619
UGUUCCCUGGUUGGCGUUC
6620
UGUUCCCUGGUUGGCGUUCdTsdT
antis


 


1206-1225
6621
CCAACCAGGGAACAAAUCC
6622
ccAAccAGGGAAcAAAuccdTsdT
sense


 


1206-1225
6623
GGAUUUGUUCCCUGGUUGG
6624
GGAUUUGUUCCCUGGUUGGdTsdT
antis


 


1208-1227
6625
AACCAGGGAACAAAUCCGA
6626
AAccAGGGAAcAAAuccGAdTsdT
sense


 


1208-1227
6627
UCGGAUUUGUUCCCUGGUU
6628
UCGGAUUUGUUCCCUGGUUdTsdT
antis


 


1218-1237
6629
CAAAUCCGAGAGAUGAACC
6630
cAAAuccGAGAGAuGAAccdTsdT
sense


 


1218-1237
6631
GGUUCAUCUCUCGGAUUUG
6632
GGUUcAUCUCUCGGAUUUGdTsdT
antis


 


1220-1239
6633
AAUCCGAGAGAUGAACCCU
6634
AAuccGAGAGAuGAAcccudTsdT
sense


 


1220-1239
6635
AGGGUUCAUCUCUCGGAUU
6636
AGGGUUcAUCUCUCGGAUUdTsdT
antis


 


1221-1240
6637
AUCCGAGAGAUGAACCCUA
6638
AuccGAGAGAuGAAcccuAdTsdT
sense


 


1221-1240
6639
UAGGGUUCAUCUCUCGGAU
6640
uAGGGUUcAUCUCUCGGAUdTsdT
antis


 


1453-1472
6641
CCCCCCUGUUCAACUUCAG
6642
ccccccuGuucAAcuucAGdTsdT
sense


 


1453-1472
6643
CUGAAGUUGAACAGGGGGG
6644
CUGAAGUUGAAcAGGGGGGdTsdT
antis


 


1675-1694
6645
GACUACCCCUCCACGUCCA
6646
GAcuAccccuccAcGuccAdTsdT
sense


 


1675-1694
6647
UGGACGUGGAGGGGUAGUC
6648
UGGACGUGGAGGGGuAGUCdTsdT
antis


 


1676-1695
6649
ACUACCCCUCCACGUCCAU
6650
AcuAccccuccAcGuccAudTsdT
sense


 


1676-1695
6651
AUGGACGUGGAGGGGUAGU
6652
AUGGACGUGGAGGGGuAGUdTsdT
antis


 


1677-1696
6653
CUACCCCUCCACGUCCAUC
6654
cuAccccuccAcGuccAucdTsdT
sense


 


1677-1696
6655
GAUGGACGUGGAGGGGUAG
6656
GAUGGACGUGGAGGGGuAGdTsdT
antis


 


1703-1722
6657
GCCCAAGUGGCGCUGGGAA
6658
GcccAAGuGGcGcuGGGAAdTsdT
sense


 


1703-1722
6659
UUCCCAGCGCCACUUGGGC
6660
UUCCcAGCGCcACUUGGGCdTsdT
antis


 


1706-1725
6661
CAAGUGGCGCUGGGAAGGG
6662
cAAGuGGcGcuGGGAAGGGdTsdT
sense


 


1706-1725
6663
CCCUUCCCAGCGCCACUUG
6664
CCCUUCCcAGCGCcACUUGdTsdT
antis


 


1752-1771
6665
GGCUGGGCCCCUAGACUAG
6666
GGcuGGGccccuAGAcuAGdTsdT
sense


 


1752-1771
6667
CUAGUCUAGGGGCCCAGCC
6668
CuAGUCuAGGGGCCcAGCCdTsdT
antis


 


1755-1774
6669
UGGGCCCCUAGACUAGAGG
6670
uGGGccccuAGAcuAGAGGdTsdT
sense


 


1755-1774
6671
CCUCUAGUCUAGGGGCCCA
6672
CCUCuAGUCuAGGGGCCcAdTsdT
antis


 


1758-1777
6673
GCCCCUAGACUAGAGGGCA
6674
GccccuAGAcuAGAGGGcAdTsdT
sense


 


1758-1777
6675
UGCCCUCUAGUCUAGGGGC
6676
UGCCCUCuAGUCuAGGGGCdTsdT
antis


 


1761-1780
6677
CCUAGACUAGAGGGCAGAG
6678
ccuAGAcuAGAGGGcAGAGdTsdT
sense


 


1761-1780
6679
CUCUGCCCUCUAGUCUAGG
6680
CUCUGCCCUCuAGUCuAGGdTsdT
antis


 


1765-1784
6681
GACUAGAGGGCAGAGGUAA
6682
GAcuAGAGGGcAGAGGuAAdTsdT
sense


 


1765-1784
6683
UUACCUCUGCCCUCUAGUC
6684
UuACCUCUGCCCUCuAGUCdTsdT
antis


 


1777-1796
6685
GAGGUAAAUGAACUACCCC
6686
GAGGuAAAuGAAcuAccccdTsdT
sense


 


1777-1796
6687
GGGGUAGUUCAUUUACCUC
6688
GGGGuAGUUcAUUuACCUCdTsdT
antis


 


1778-1797
6689
AGGUAAAUGAACUACCCCC
6690
AGGuAAAuGAAcuAcccccdTsdT
sense


 


1778-1797
6691
GGGGGUAGUUCAUUUACCU
6692
GGGGGuAGUUcAUUuACCUdTsdT
antis


 


1779-1798
6693
GGUAAAUGAACUACCCCCA
6694
GGuAAAuGAAcuAcccccAdTsdT
sense


 


1779-1798
6695
UGGGGGUAGUUCAUUUACC
6696
UGGGGGuAGUUcAUUuACCdTsdT
antis


 


1781-1800
6697
UAAAUGAACUACCCCCAGC
6698
uAAAuGAAcuAcccccAGcdTsdT
sense


 


1781-1800
6699
GCUGGGGGUAGUUCAUUUA
6700
GCUGGGGGuAGUUcAUUuAdTsdT
antis


 


1792-1811
6701
CCCCCAGCAUCUAGGCCUC
6702
cccccAGcAucuAGGccucdTsdT
sense


 


1792-1811
6703
GAGGCCUAGAUGCUGGGGG
6704
GAGGCCuAGAUGCUGGGGGdTsdT
antis


 


1796-1815
6705
CAGCAUCUAGGCCUCCCUC
6706
cAGcAucuAGGccucccucdTsdT
sense


 


1796-1815
6707
GAGGGAGGCCUAGAUGCUG
6708
GAGGGAGGCCuAGAUGCUGdTsdT
antis


 


1885-1904
6709
AGGACGGGGUUUGGGGGUG
6710
AGGAcGGGGuuuGGGGGuGdTsdT
sense


 


1885-1904
6711
CACCCCCAAACCCCGUCCU
6712
cACCCCcAAACCCCGUCCUdTsdT
antis


 


522-541
6713
CCAGAGCGUUCCCAAGAAG
6714
ccAGAGcGuucccAAGAAGdTsdT
sense


 


522-541
6715
CUUCUUGGGAACGCUCUGG
6716
CUUCUUGGGAACGCUCUGGdTsdT
antis


 


526-545
6717
AGCGUUCCCAAGAAGUGGC
6718
AGcGuucccAAGAAGuGGcdTsdT
sense


 


526-545
6719
GCCACUUCUUGGGAACGCU
6720
GCcACUUCUUGGGAACGCUdTsdT
antis


 


700-719
6721
GCAAUAUUGUGAGGCUGCG
6722
GcAAuAuuGuGAGGcuGcGdTsdT
sense


 


700-719
6723
CGCAGCCUCACAAUAUUGC
6724
CGcAGCCUcAcAAuAUUGCdTsdT
antis


 


873-892
6725
CUCUUCCGGAGCUUGGCCU
6726
cucuuccGGAGcuuGGccudTsdT
sense


 


873-892
6727
AGGCCAAGCUCCGGAAGAG
6728
AGGCcAAGCUCCGGAAGAGdTsdT
antis


 


1256-1275
6729
GUUCCCCCAGAUCAAAGCU
6730
GuucccccAGAucAAAGcudTsdT
sense


 


1256-1275
6731
AGCUUUGAUCUGGGGGAAC
6732
AGCUUUGAUCUGGGGGAACdTsdT
antis


 


1317-1336
6733
GAGGCCAUUGCACUCUGCU
6734
GAGGccAuuGcAcucuGcudTsdT
sense


 


1317-1336
6735
AGCAGAGUGCAAUGGCCUC
6736
AGcAGAGUGcAAUGGCCUCdTsdT
antis


 


1512-1531
6737
CUCAUCCCUCCUCACUUGA
6738
cucAucccuccucAcuuGAdTsdT
sense


 


1512-1531
6739
UCAAGUGAGGAGGGAUGAG
6740
UcAAGUGAGGAGGGAUGAGdTsdT
antis


 


1764-1783
6741
AGACUAGAGGGCAGAGGUA
6742
AGAcuAGAGGGcAGAGGuAdTsdT
sense


 


1764-1783
6743
UACCUCUGCCCUCUAGUCU
6744
uACCUCUGCCCUCuAGUCUdTsdT
antis


 


236-255
6745
CCGGGCGCGGACCAGCUCG
6746
ccGGGcGcGGAccAGcucGdTsdT
sense


 


236-255
6747
CGAGCUGGUCCGCGCCCGG
6748
CGAGCUGGUCCGCGCCCGGdTsdT
antis


 


914-933
6749
UCACCGUGACAUCAAGCCC
6750
ucAccGuGAcAucAAGcccdTsdT
sense


 


914-933
6751
GGGCUUGAUGUCACGGUGA
6752
GGGCUUGAUGUcACGGUGAdTsdT
antis


 


234-253
6753
GGCCGGGCGCGGACCAGCU
6754
GGccGGGcGcGGAccAGcudTsdT
sense


 


234-253
6755
AGCUGGUCCGCGCCCGGCC
6756
AGCUGGUCCGCGCCCGGCCdTsdT
antis


 


520-539
6757
GCCCAGAGCGUUCCCAAGA
6758
GcccAGAGcGuucccAAGAdTsdT
sense


 


520-539
6759
UCUUGGGAACGCUCUGGGC
6760
UCUUGGGAACGCUCUGGGCdTsdT
antis


 


525-544
6761
GAGCGUUCCCAAGAAGUGG
6762
GAGcGuucccAAGAAGuGGdTsdT
sense


 


525-544
6763
CCACUUCUUGGGAACGCUC
6764
CcACUUCUUGGGAACGCUCdTsdT
antis


 


549-568
6765
ACUGACAUCAAAGUGAUUG
6766
AcuGAcAucAAAGuGAuuGdTsdT
sense


 


549-568
6767
CAAUCACUUUGAUGUCAGU
6768
cAAUcACUUUGAUGUcAGUdTsdT
antis


 


555-574
6769
AUCAAAGUGAUUGGUAAUG
6770
AucAAAGuGAuuGGuAAuGdTsdT
sense


 


555-574
6771
CAUUACCAAUCACUUUGAU
6772
cAUuACcAAUcACUUUGAUdTsdT
antis


 


558-577
6773
AAAGUGAUUGGUAAUGGCU
6774
AAAGuGAuuGGuAAuGGcudTsdT
sense


 


558-577
6775
AGCCAUUACCAAUCACUUU
6776
AGCcAUuACcAAUcACUUUdTsdT
antis


 


567-586
6777
GGUAAUGGCUCAUUCGGAG
6778
GGuAAuGGcucAuucGGAGdTsdT
sense


 


567-586
6779
CUCCGAAUGAGCCAUUACC
6780
CUCCGAAUGAGCcAUuACCdTsdT
antis


 


571-590
6781
AUGGCUCAUUCGGAGUAGU
6782
AuGGcucAuucGGAGuAGudTsdT
sense


 


571-590
6783
ACUACUCCGAAUGAGCCAU
6784
ACuACUCCGAAUGAGCcAUdTsdT
antis


 


685-704
6785
GUAAGCUGGACCACUGCAA
6786
GuAAGcuGGAccAcuGcAAdTsdT
sense


 


685-704
6787
UUGCAGUGGUCCAGCUUAC
6788
UUGcAGUGGUCcAGCUuACdTsdT
antis


 


764-783
6789
GAAUCUGGUGCUGGAGUAU
6790
GAAucuGGuGcuGGAGuAudTsdT
sense


 


764-783
6791
AUACUCCAGCACCAGAUUC
6792
AuACUCcAGcACcAGAUUCdTsdT
antis


 


777-796
6793
GAGUAUGUGCCCGAGACGG
6794
GAGuAuGuGcccGAGAcGGdTsdT
sense


 


777-796
6795
CCGUCUCGGGCACAUACUC
6796
CCGUCUCGGGcAcAuACUCdTsdT
antis


 


783-802
6797
GUGCCCGAGACGGUGUACC
6798
GuGcccGAGAcGGuGuAccdTsdT
sense


 


783-802
6799
GGUACACCGUCUCGGGCAC
6800
GGuAcACCGUCUCGGGcACdTsdT
antis


 


802-821
6801
GAGUGGCCCGCCACUUCAC
6802
GAGuGGcccGccAcuucAcdTsdT
sense


 


802-821
6803
GUGAAGUGGCGGGCCACUC
6804
GUGAAGUGGCGGGCcACUCdTsdT
antis


 


818-837
6805
CACCAAGGCCAAGCUGAUC
6806
cAccAAGGccAAGcuGAucdTsdT
sense


 


818-837
6807
GAUCAGCUUGGCCUUGGUG
6808
GAUcAGCUUGGCCUUGGUGdTsdT
antis


 


852-871
6809
AUCAAGGUGUACAUGUACC
6810
AucAAGGuGuAcAuGuAccdTsdT
sense


 


852-871
6811
GGUACAUGUACACCUUGAU
6812
GGuAcAUGuAcACCUUGAUdTsdT
antis


 


853-872
6813
UCAAGGUGUACAUGUACCA
6814
ucAAGGuGuAcAuGuAccAdTsdT
sense


 


853-872
6815
UGGUACAUGUACACCUUGA
6816
UGGuAcAUGuAcACCUUGAdTsdT
antis


 


937-956
6817
AUUUGCUUGUGGACCCUGA
6818
AuuuGcuuGuGGAcccuGAdTsdT
sense


 


937-956
6819
UCAGGGUCCACAAGCAAAU
6820
UcAGGGUCcAcAAGcAAAUdTsdT
antis


 


942-961
6821
CUUGUGGACCCUGACACUG
6822
cuuGuGGAcccuGAcAcuGdTsdT
sense


 


942-961
6823
CAGUGUCAGGGUCCACAAG
6824
cAGUGUcAGGGUCcAcAAGdTsdT
antis


 


967-986
6825
UCAAGCUCUGCGAUUUUGG
6826
ucAAGcucuGcGAuuuuGGdTsdT
sense


 


967-986
6827
CCAAAAUCGCAGAGCUUGA
6828
CcAAAAUCGcAGAGCUUGAdTsdT
antis


 


968-987
6829
CAAGCUCUGCGAUUUUGGC
6830
cAAGcucuGcGAuuuuGGcdTsdT
sense


 


968-987
6831
GCCAAAAUCGCAGAGCUUG
6832
GCcAAAAUCGcAGAGCUUGdTsdT
antis


 


976-995
6833
GCGAUUUUGGCAGUGCAAA
6834
GcGAuuuuGGcAGuGcAAAdTsdT
sense


 


976-995
6835
UUUGCACUGCCAAAAUCGC
6836
UUUGcACUGCcAAAAUCGCdTsdT
antis


 


 984-1003
6837
GGCAGUGCAAAGCAGCUGG
6838
GGcAGuGcAAAGcAGcuGGdTsdT
sense


 


 984-1003
6839
CCAGCUGCUUUGCACUGCC
6840
CcAGCUGCUUUGcACUGCCdTsdT
antis


 


1039-1058
6841
GGUACUACCGUGCUCCAGA
6842
GGuAcuAccGuGcuccAGAdTsdT
sense


 


1039-1058
6843
UCUGGAGCACGGUAGUACC
6844
UCUGGAGcACGGuAGuACCdTsdT
antis


 


1044-1063
6845
UACCGUGCUCCAGAACUCA
6846
uAccGuGcuccAGAAcucAdTsdT
sense


 


1044-1063
6847
UGAGUUCUGGAGCACGGUA
6848
UGAGUUCUGGAGcACGGuAdTsdT
antis


 


1185-1204
6849
AUCAUCAAGGUACUAGGAA
6850
AucAucAAGGuAcuAGGAAdTsdT
sense


 


1185-1204
6851
UUCCUAGUACCUUGAUGAU
6852
UUCCuAGuACCUUGAUGAUdTsdT
antis


 


1188-1207
6853
AUCAAGGUACUAGGAACGC
6854
AucAAGGuAcuAGGAAcGcdTsdT
sense


 


1188-1207
6855
GCGUUCCUAGUACCUUGAU
6856
GCGUUCCuAGuACCUUGAUdTsdT
antis


 


1196-1215
6857
ACUAGGAACGCCAACCAGG
6858
AcuAGGAAcGccAAccAGGdTsdT
sense


 


1196-1215
6859
CCUGGUUGGCGUUCCUAGU
6860
CCUGGUUGGCGUUCCuAGUdTsdT
antis


 


1204-1223
6861
CGCCAACCAGGGAACAAAU
6862
cGccAAccAGGGAAcAAAudTsdT
sense


 


1204-1223
6863
AUUUGUUCCCUGGUUGGCG
6864
AUUUGUUCCCUGGUUGGCGdTsdT
antis


 


1213-1232
6865
GGGAACAAAUCCGAGAGAU
6866
GGGAAcAAAuccGAGAGAudTsdT
sense


 


1213-1232
6867
AUCUCUCGGAUUUGUUCCC
6868
AUCUCUCGGAUUUGUUCCCdTsdT
antis


 


1215-1234
6869
GAACAAAUCCGAGAGAUGA
6870
GAAcAAAuccGAGAGAuGAdTsdT
sense


 


1215-1234
6871
UCAUCUCUCGGAUUUGUUC
6872
UcAUCUCUCGGAUUUGUUCdTsdT
antis


 


1216-1235
6873
AACAAAUCCGAGAGAUGAA
6874
AAcAAAuccGAGAGAuGAAdTsdT
sense


 


1216-1235
6875
UUCAUCUCUCGGAUUUGUU
6876
UUcAUCUCUCGGAUUUGUUdTsdT
antis


 


1217-1236
6877
ACAAAUCCGAGAGAUGAAC
6878
AcAAAuccGAGAGAuGAAcdTsdT
sense


 


1217-1236
6879
GUUCAUCUCUCGGAUUUGU
6880
GUUcAUCUCUCGGAUUUGUdTsdT
antis


 


1429-1448
6881
AGCUCCCCAACGACCGCCC
6882
AGcuccccAAcGAccGcccdTsdT
sense


 


1429-1448
6883
GGGCGGUCGUUGGGGAGCU
6884
GGGCGGUCGUUGGGGAGCUdTsdT
antis


 


1430-1449
6885
GCUCCCCAACGACCGCCCG
6886
GcuccccAAcGAccGcccGdTsdT
sense


 


1430-1449
6887
CGGGCGGUCGUUGGGGAGC
6888
CGGGCGGUCGUUGGGGAGCdTsdT
antis


 


1580-1599
6889
CUCACAAGCUUUAACUGAA
6890
cucAcAAGcuuuAAcuGAAdTsdT
sense


 


1580-1599
6891
UUCAGUUAAAGCUUGUGAG
6892
UUcAGUuAAAGCUUGUGAGdTsdT
antis


 


1667-1686
6893
GCCCCACCGACUACCCCUC
6894
GccccAccGAcuAccccucdTsdT
sense


 


1667-1686
6895
GAGGGGUAGUCGGUGGGGC
6896
GAGGGGuAGUCGGUGGGGCdTsdT
antis


 


1669-1688
6897
CCCACCGACUACCCCUCCA
6898
cccAccGAcuAccccuccAdTsdT
sense


 


1669-1688
6899
UGGAGGGGUAGUCGGUGGG
6900
UGGAGGGGuAGUCGGUGGGdTsdT
antis


 


1682-1701
6901
CCUCCACGUCCAUCUGGGA
6902
ccuccAcGuccAucuGGGAdTsdT
sense


 


1682-1701
6903
UCCCAGAUGGACGUGGAGG
6904
UCCcAGAUGGACGUGGAGGdTsdT
antis


 


1685-1704
6905
CCACGUCCAUCUGGGAAGG
6906
ccAcGuccAucuGGGAAGGdTsdT
sense


 


1685-1704
6907
CCUUCCCAGAUGGACGUGG
6908
CCUUCCcAGAUGGACGUGGdTsdT
antis


 


1704-1723
6909
CCCAAGUGGCGCUGGGAAG
6910
cccAAGuGGcGcuGGGAAGdTsdT
sense


 


1704-1723
6911
CUUCCCAGCGCCACUUGGG
6912
CUUCCcAGCGCcACUUGGGdTsdT
antis


 


1705-1724
6913
CCAAGUGGCGCUGGGAAGG
6914
ccAAGuGGcGcuGGGAAGGdTsdT
sense


 


1705-1724
6915
CCUUCCCAGCGCCACUUGG
6916
CCUUCCcAGCGCcACUUGGdTsdT
antis


 


1730-1749
6917
CAGCCCAUCAAGCUCCUGC
6918
cAGcccAucAAGcuccuGcdTsdT
sense


 


1730-1749
6919
GCAGGAGCUUGAUGGGCUG
6920
GcAGGAGCUUGAUGGGCUGdTsdT
antis


 


1753-1772
6921
GCUGGGCCCCUAGACUAGA
6922
GcuGGGccccuAGAcuAGAdTsdT
sense


 


1753-1772
6923
UCUAGUCUAGGGGCCCAGC
6924
UCuAGUCuAGGGGCCcAGCdTsdT
antis


 


1759-1778
6925
CCCCUAGACUAGAGGGCAG
6926
ccccuAGAcuAGAGGGcAGdTsdT
sense


 


1759-1778
6927
CUGCCCUCUAGUCUAGGGG
6928
CUGCCCUCuAGUCuAGGGGdTsdT
antis


 


1760-1779
6929
CCCUAGACUAGAGGGCAGA
6930
cccuAGAcuAGAGGGcAGAdTsdT
sense


 


1760-1779
6931
UCUGCCCUCUAGUCUAGGG
6932
UCUGCCCUCuAGUCuAGGGdTsdT
antis


 


1763-1782
6933
UAGACUAGAGGGCAGAGGU
6934
uAGAcuAGAGGGcAGAGGudTsdT
sense


 


1763-1782
6935
ACCUCUGCCCUCUAGUCUA
6936
ACCUCUGCCCUCuAGUCuAdTsdT
antis


 


1773-1792
6937
GGCAGAGGUAAAUGAACUA
6938
GGcAGAGGuAAAuGAAcuAdTsdT
sense


 


1773-1792
6939
UAGUUCAUUUACCUCUGCC
6940
uAGUUcAUUuACCUCUGCCdTsdT
antis


 


1774-1793
6941
GCAGAGGUAAAUGAACUAC
6942
GcAGAGGuAAAuGAAcuAcdTsdT
sense


 


1774-1793
6943
GUAGUUCAUUUACCUCUGC
6944
GuAGUUcAUUuACCUCUGCdTsdT
antis


 


1782-1801
6945
AAAUGAACUACCCCCAGCA
6946
AAAuGAAcuAcccccAGcAdTsdT
sense


 


1782-1801
6947
UGCUGGGGGUAGUUCAUUU
6948
UGCUGGGGGuAGUUcAUUUdTsdT
antis


 


1784-1803
6949
AUGAACUACCCCCAGCAUC
6950
AuGAAcuAcccccAGcAucdTsdT
sense


 


1784-1803
6951
GAUGCUGGGGGUAGUUCAU
6952
GAUGCUGGGGGuAGUUcAUdTsdT
antis


 


1785-1804
6953
UGAACUACCCCCAGCAUCU
6954
uGAAcuAcccccAGcAucudTsdT
sense


 


1785-1804
6955
AGAUGCUGGGGGUAGUUCA
6956
AGAUGCUGGGGGuAGUUcAdTsdT
antis


 


1790-1809
6957
UACCCCCAGCAUCUAGGCC
6958
uAcccccAGcAucuAGGccdTsdT
sense


 


1790-1809
6959
GGCCUAGAUGCUGGGGGUA
6960
GGCCuAGAUGCUGGGGGuAdTsdT
antis


 


1794-1813
6961
CCCAGCAUCUAGGCCUCCC
6962
cccAGcAucuAGGccucccdTsdT
sense


 


1794-1813
6963
GGGAGGCCUAGAUGCUGGG
6964
GGGAGGCCuAGAUGCUGGGdTsdT
antis


 


1795-1814
6965
CCAGCAUCUAGGCCUCCCU
6966
ccAGcAucuAGGccucccudTsdT
sense


 


1795-1814
6967
AGGGAGGCCUAGAUGCUGG
6968
AGGGAGGCCuAGAUGCUGGdTsdT
antis


 


1882-1901
6969
GGAAGGACGGGGUUUGGGG
6970
GGAAGGAcGGGGuuuGGGGdTsdT
sense


 


1882-1901
6971
CCCCAAACCCCGUCCUUCC
6972
CCCcAAACCCCGUCCUUCCdTsdT
antis


 


1883-1902
6973
GAAGGACGGGGUUUGGGGG
6974
GAAGGAcGGGGuuuGGGGGdTsdT
sense


 


1883-1902
6975
CCCCCAAACCCCGUCCUUC
6976
CCCCcAAACCCCGUCCUUCdTsdT
antis


 


1913-1932
6977
UCUACCCCCUUGGUCCCCU
6978
ucuAcccccuuGGuccccudTsdT
sense


 


1913-1932
6979
AGGGGACCAAGGGGGUAGA
6980
AGGGGACcAAGGGGGuAGAdTsdT
antis


 


68-87
6981
CGGAGCCGGAGCCCGAACG
6982
cGGAGccGGAGcccGAAcGdTsdT
sense


 


68-87
6983
CGUUCGGGCUCCGGCUCCG
6984
CGUUCGGGCUCCGGCUCCGdTsdT
antis


 


117-136
6985
GAGGCGGCGGCAGAGGCAG
6986
GAGGcGGcGGcAGAGGcAGdTsdT
sense


 


117-136
6987
CUGCCUCUGCCGCCGCCUC
6988
CUGCCUCUGCCGCCGCCUCdTsdT
antis


 


188-207
6989
CGCCAUGAGCGGCGGCGGG
6990
cGccAuGAGcGGcGGcGGGdTsdT
sense


 


188-207
6991
CCCGCCGCCGCUCAUGGCG
6992
CCCGCCGCCGCUcAUGGCGdTsdT
antis


 


219-238
6993
GGCCCUGGGGGCUCGGGCC
6994
GGcccuGGGGGcucGGGccdTsdT
sense


 


219-238
6995
GGCCCGAGCCCCCAGGGCC
6996
GGCCCGAGCCCCcAGGGCCdTsdT
antis


 


220-239
6997
GCCCUGGGGGCUCGGGCCG
6998
GcccuGGGGGcucGGGccGdTsdT
sense


 


220-239
6999
CGGCCCGAGCCCCCAGGGC
7000
CGGCCCGAGCCCCcAGGGCdTsdT
antis


 


233-252
7001
GGGCCGGGCGCGGACCAGC
7002
GGGccGGGcGcGGAccAGcdTsdT
sense


 


233-252
7003
GCUGGUCCGCGCCCGGCCC
7004
GCUGGUCCGCGCCCGGCCCdTsdT
antis


 


237-256
7005
CGGGCGCGGACCAGCUCGU
7006
cGGGcGcGGAccAGcucGudTsdT
sense


 


237-256
7007
ACGAGCUGGUCCGCGCCCG
7008
ACGAGCUGGUCCGCGCCCGdTsdT
antis


 


308-327
7009
GGCCUCUGGCCCAGGAGGC
7010
GGccucuGGcccAGGAGGcdTsdT
sense


 


308-327
7011
GCCUCCUGGGCCAGAGGCC
7012
GCCUCCUGGGCcAGAGGCCdTsdT
antis


 


311-330
7013
CUCUGGCCCAGGAGGCACU
7014
cucuGGcccAGGAGGcAcudTsdT
sense


 


311-330
7015
AGUGCCUCCUGGGCCAGAG
7016
AGUGCCUCCUGGGCcAGAGdTsdT
antis


 


351-370
7017
GGGGCUAUGGGUGGGGGCG
7018
GGGGcuAuGGGuGGGGGcGdTsdT
sense


 


351-370
7019
CGCCCCCACCCAUAGCCCC
7020
CGCCCCcACCcAuAGCCCCdTsdT
antis


 


353-372
7021
GGCUAUGGGUGGGGGCGUG
7022
GGcuAuGGGuGGGGGcGuGdTsdT
sense


 


353-372
7023
CACGCCCCCACCCAUAGCC
7024
cACGCCCCcACCcAuAGCCdTsdT
antis


 


355-374
7025
CUAUGGGUGGGGGCGUGGG
7026
cuAuGGGuGGGGGcGuGGGdTsdT
sense


 


355-374
7027
CCCACGCCCCCACCCAUAG
7028
CCcACGCCCCcACCcAuAGdTsdT
antis


 


357-376
7029
AUGGGUGGGGGCGUGGGAG
7030
AuGGGuGGGGGcGuGGGAGdTsdT
sense


 


357-376
7031
CUCCCACGCCCCCACCCAU
7032
CUCCcACGCCCCcACCcAUdTsdT
antis


 


361-380
7033
GUGGGGGCGUGGGAGCCUC
7034
GuGGGGGcGuGGGAGccucdTsdT
sense


 


361-380
7035
GAGGCUCCCACGCCCCCAC
7036
GAGGCUCCcACGCCCCcACdTsdT
antis


 


363-382
7037
GGGGGCGUGGGAGCCUCGA
7038
GGGGGcGuGGGAGccucGAdTsdT
sense


 


363-382
7039
UCGAGGCUCCCACGCCCCC
7040
UCGAGGCUCCcACGCCCCCdTsdT
antis


 


364-383
7041
GGGGCGUGGGAGCCUCGAG
7042
GGGGcGuGGGAGccucGAGdTsdT
sense


 


364-383
7043
CUCGAGGCUCCCACGCCCC
7044
CUCGAGGCUCCcACGCCCCdTsdT
antis


 


365-384
7045
GGGCGUGGGAGCCUCGAGC
7046
GGGcGuGGGAGccucGAGcdTsdT
sense


 


365-384
7047
GCUCGAGGCUCCCACGCCC
7048
GCUCGAGGCUCCcACGCCCdTsdT
antis


 


366-385
7049
GGCGUGGGAGCCUCGAGCU
7050
GGcGuGGGAGccucGAGcudTsdT
sense


 


366-385
7051
AGCUCGAGGCUCCCACGCC
7052
AGCUCGAGGCUCCcACGCCdTsdT
antis


 


368-387
7053
CGUGGGAGCCUCGAGCUCC
7054
cGuGGGAGccucGAGcuccdTsdT
sense


 


368-387
7055
GGAGCUCGAGGCUCCCACG
7056
GGAGCUCGAGGCUCCcACGdTsdT
antis


 


485-504
7057
GAAGGUGACCACAGUGGUA
7058
GAAGGuGAccAcAGuGGuAdTsdT
sense


 


485-504
7059
UACCACUGUGGUCACCUUC
7060
uACcACUGUGGUcACCUUCdTsdT
antis


 


487-506
7061
AGGUGACCACAGUGGUAGC
7062
AGGuGAccAcAGuGGuAGcdTsdT
sense


 


487-506
7063
GCUACCACUGUGGUCACCU
7064
GCuACcACUGUGGUcACCUdTsdT
antis


 


488-507
7065
GGUGACCACAGUGGUAGCC
7066
GGuGAccAcAGuGGuAGccdTsdT
sense


 


488-507
7067
GGCUACCACUGUGGUCACC
7068
GGCuACcACUGUGGUcACCdTsdT
antis


 


547-566
7069
ACACUGACAUCAAAGUGAU
7070
AcAcuGAcAucAAAGuGAudTsdT
sense


 


547-566
7071
AUCACUUUGAUGUCAGUGU
7072
AUcACUUUGAUGUcAGUGUdTsdT
antis


 


548-567
7073
CACUGACAUCAAAGUGAUU
7074
cAcuGAcAucAAAGuGAuudTsdT
sense


 


548-567
7075
AAUCACUUUGAUGUCAGUG
7076
AAUcACUUUGAUGUcAGUGdTsdT
antis


 


551-570
7077
UGACAUCAAAGUGAUUGGU
7078
uGAcAucAAAGuGAuuGGudTsdT
sense


 


551-570
7079
ACCAAUCACUUUGAUGUCA
7080
ACcAAUcACUUUGAUGUcAdTsdT
antis


 


552-571
7081
GACAUCAAAGUGAUUGGUA
7082
GAcAucAAAGuGAuuGGuAdTsdT
sense


 


552-571
7083
UACCAAUCACUUUGAUGUC
7084
uACcAAUcACUUUGAUGUCdTsdT
antis


 


553-572
7085
ACAUCAAAGUGAUUGGUAA
7086
AcAucAAAGuGAuuGGuAAdTsdT
sense


 


553-572
7087
UUACCAAUCACUUUGAUGU
7088
UuACcAAUcACUUUGAUGUdTsdT
antis


 


554-573
7089
CAUCAAAGUGAUUGGUAAU
7090
cAucAAAGuGAuuGGuAAudTsdT
sense


 


554-573
7091
AUUACCAAUCACUUUGAUG
7092
AUuACcAAUcACUUUGAUGdTsdT
antis


 


556-575
7093
UCAAAGUGAUUGGUAAUGG
7094
ucAAAGuGAuuGGuAAuGGdTsdT
sense


 


556-575
7095
CCAUUACCAAUCACUUUGA
7096
CcAUuACcAAUcACUUUGAdTsdT
antis


 


557-576
7097
CAAAGUGAUUGGUAAUGGC
7098
cAAAGuGAuuGGuAAuGGcdTsdT
sense


 


557-576
7099
GCCAUUACCAAUCACUUUG
7100
GCcAUuACcAAUcACUUUGdTsdT
antis


 


562-581
7101
UGAUUGGUAAUGGCUCAUU
7102
uGAuuGGuAAuGGcucAuudTsdT
sense


 


562-581
7103
AAUGAGCCAUUACCAAUCA
7104
AAUGAGCcAUuACcAAUcAdTsdT
antis


 


563-582
7105
GAUUGGUAAUGGCUCAUUC
7106
GAuuGGuAAuGGcucAuucdTsdT
sense


 


563-582
7107
GAAUGAGCCAUUACCAAUC
7108
GAAUGAGCcAUuACcAAUCdTsdT
antis


 


564-583
7109
AUUGGUAAUGGCUCAUUCG
7110
AuuGGuAAuGGcucAuucGdTsdT
sense


 


564-583
7111
CGAAUGAGCCAUUACCAAU
7112
CGAAUGAGCcAUuACcAAUdTsdT
antis


 


565-584
7113
UUGGUAAUGGCUCAUUCGG
7114
uuGGuAAuGGcucAuucGGdTsdT
sense


 


565-584
7115
CCGAAUGAGCCAUUACCAA
7116
CCGAAUGAGCcAUuACcAAdTsdT
antis


 


566-585
7117
UGGUAAUGGCUCAUUCGGA
7118
uGGuAAuGGcucAuucGGAdTsdT
sense


 


566-585
7119
UCCGAAUGAGCCAUUACCA
7120
UCCGAAUGAGCcAUuACcAdTsdT
antis


 


627-646
7121
GCCAUCAAGAAGGUUCUUC
7122
GccAucAAGAAGGuucuucdTsdT
sense


 


627-646
7123
GAAGAACCUUCUUGAUGGC
7124
GAAGAACCUUCUUGAUGGCdTsdT
antis


 


631-650
7125
UCAAGAAGGUUCUUCAGGA
7126
ucAAGAAGGuucuucAGGAdTsdT
sense


 


631-650
7127
UCCUGAAGAACCUUCUUGA
7128
UCCUGAAGAACCUUCUUGAdTsdT
antis


 


632-651
7129
CAAGAAGGUUCUUCAGGAC
7130
cAAGAAGGuucuucAGGAcdTsdT
sense


 


632-651
7131
GUCCUGAAGAACCUUCUUG
7132
GUCCUGAAGAACCUUCUUGdTsdT
antis


 


634-653
7133
AGAAGGUUCUUCAGGACAA
7134
AGAAGGuucuucAGGAcAAdTsdT
sense


 


634-653
7135
UUGUCCUGAAGAACCUUCU
7136
UUGUCCUGAAGAACCUUCUdTsdT
antis


 


635-654
7137
GAAGGUUCUUCAGGACAAA
7138
GAAGGuucuucAGGAcAAAdTsdT
sense


 


635-654
7139
UUUGUCCUGAAGAACCUUC
7140
UUUGUCCUGAAGAACCUUCdTsdT
antis


 


638-657
7141
GGUUCUUCAGGACAAAAGG
7142
GGuucuucAGGAcAAAAGGdTsdT
sense


 


638-657
7143
CCUUUUGUCCUGAAGAACC
7144
CCUUUUGUCCUGAAGAACCdTsdT
antis


 


639-658
7145
GUUCUUCAGGACAAAAGGU
7146
GuucuucAGGAcAAAAGGudTsdT
sense


 


639-658
7147
ACCUUUUGUCCUGAAGAAC
7148
ACCUUUUGUCCUGAAGAACdTsdT
antis


 


640-659
7149
UUCUUCAGGACAAAAGGUU
7150
uucuucAGGAcAAAAGGuudTsdT
sense


 


640-659
7151
AACCUUUUGUCCUGAAGAA
7152
AACCUUUUGUCCUGAAGAAdTsdT
antis


 


641-660
7153
UCUUCAGGACAAAAGGUUC
7154
ucuucAGGAcAAAAGGuucdTsdT
sense


 


641-660
7155
GAACCUUUUGUCCUGAAGA
7156
GAACCUUUUGUCCUGAAGAdTsdT
antis


 


642-661
7157
CUUCAGGACAAAAGGUUCA
7158
cuucAGGAcAAAAGGuucAdTsdT
sense


 


642-661
7159
UGAACCUUUUGUCCUGAAG
7160
UGAACCUUUUGUCCUGAAGdTsdT
antis


 


643-662
7161
UUCAGGACAAAAGGUUCAA
7162
uucAGGAcAAAAGGuucAAdTsdT
sense


 


643-662
7163
UUGAACCUUUUGUCCUGAA
7164
UUGAACCUUUUGUCCUGAAdTsdT
antis


 


644-663
7165
UCAGGACAAAAGGUUCAAG
7166
ucAGGAcAAAAGGuucAAGdTsdT
sense


 


644-663
7167
CUUGAACCUUUUGUCCUGA
7168
CUUGAACCUUUUGUCCUGAdTsdT
antis


 


645-664
7169
CAGGACAAAAGGUUCAAGA
7170
cAGGAcAAAAGGuucAAGAdTsdT
sense


 


645-664
7171
UCUUGAACCUUUUGUCCUG
7172
UCUUGAACCUUUUGUCCUGdTsdT
antis


 


686-705
7173
UAAGCUGGACCACUGCAAU
7174
uAAGcuGGAccAcuGcAAudTsdT
sense


 


686-705
7175
AUUGCAGUGGUCCAGCUUA
7176
AUUGcAGUGGUCcAGCUuAdTsdT
antis


 


687-706
7177
AAGCUGGACCACUGCAAUA
7178
AAGcuGGAccAcuGcAAuAdTsdT
sense


 


687-706
7179
UAUUGCAGUGGUCCAGCUU
7180
uAUUGcAGUGGUCcAGCUUdTsdT
antis


 


689-708
7181
GCUGGACCACUGCAAUAUU
7182
GcuGGAccAcuGcAAuAuudTsdT
sense


 


689-708
7183
AAUAUUGCAGUGGUCCAGC
7184
AAuAUUGcAGUGGUCcAGCdTsdT
antis


 


690-709
7185
CUGGACCACUGCAAUAUUG
7186
cuGGAccAcuGcAAuAuuGdTsdT
sense


 


690-709
7187
CAAUAUUGCAGUGGUCCAG
7188
cAAuAUUGcAGUGGUCcAGdTsdT
antis


 


691-710
7189
UGGACCACUGCAAUAUUGU
7190
uGGAccAcuGcAAuAuuGudTsdT
sense


 


691-710
7191
ACAAUAUUGCAGUGGUCCA
7192
AcAAuAUUGcAGUGGUCcAdTsdT
antis


 


692-711
7193
GGACCACUGCAAUAUUGUG
7194
GGAccAcuGcAAuAuuGuGdTsdT
sense


 


692-711
7195
CACAAUAUUGCAGUGGUCC
7196
cAcAAuAUUGcAGUGGUCCdTsdT
antis


 


694-713
7197
ACCACUGCAAUAUUGUGAG
7198
AccAcuGcAAuAuuGuGAGdTsdT
sense


 


694-713
7199
CUCACAAUAUUGCAGUGGU
7200
CUcAcAAuAUUGcAGUGGUdTsdT
antis


 


696-715
7201
CACUGCAAUAUUGUGAGGC
7202
cAcuGcAAuAuuGuGAGGcdTsdT
sense


 


696-715
7203
GCCUCACAAUAUUGCAGUG
7204
GCCUcAcAAuAUUGcAGUGdTsdT
antis


 


698-717
7205
CUGCAAUAUUGUGAGGCUG
7206
cuGcAAuAuuGuGAGGcuGdTsdT
sense


 


698-717
7207
CAGCCUCACAAUAUUGCAG
7208
cAGCCUcAcAAuAUUGcAGdTsdT
antis


 


699-718
7209
UGCAAUAUUGUGAGGCUGC
7210
uGcAAuAuuGuGAGGcuGcdTsdT
sense


 


699-718
7211
GCAGCCUCACAAUAUUGCA
7212
GcAGCCUcAcAAuAUUGcAdTsdT
antis


 


718-737
7213
GGUACUUUUUCUACUCCAG
7214
GGuAcuuuuucuAcuccAGdTsdT
sense


 


718-737
7215
CUGGAGUAGAAAAAGUACC
7216
CUGGAGuAGAAAAAGuACCdTsdT
antis


 


720-739
7217
UACUUUUUCUACUCCAGUG
7218
uAcuuuuucuAcuccAGuGdTsdT
sense


 


720-739
7219
CACUGGAGUAGAAAAAGUA
7220
cACUGGAGuAGAAAAAGuAdTsdT
antis


 


721-740
7221
ACUUUUUCUACUCCAGUGG
7222
AcuuuuucuAcuccAGuGGdTsdT
sense


 


721-740
7223
CCACUGGAGUAGAAAAAGU
7224
CcACUGGAGuAGAAAAAGUdTsdT
antis


 


723-742
7225
UUUUUCUACUCCAGUGGGG
7226
uuuuucuAcuccAGuGGGGdTsdT
sense


 


723-742
7227
CCCCACUGGAGUAGAAAAA
7228
CCCcACUGGAGuAGAAAAAdTsdT
antis


 


729-748
7229
UACUCCAGUGGGGAGAAGA
7230
uAcuccAGuGGGGAGAAGAdTsdT
sense


 


729-748
7231
UCUUCUCCCCACUGGAGUA
7232
UCUUCUCCCcACUGGAGuAdTsdT
antis


 


730-749
7233
ACUCCAGUGGGGAGAAGAA
7234
AcuccAGuGGGGAGAAGAAdTsdT
sense


 


730-749
7235
UUCUUCUCCCCACUGGAGU
7236
UUCUUCUCCCcACUGGAGUdTsdT
antis


 


736-755
7237
GUGGGGAGAAGAAGGACGA
7238
GuGGGGAGAAGAAGGAcGAdTsdT
sense


 


736-755
7239
UCGUCCUUCUUCUCCCCAC
7240
UCGUCCUUCUUCUCCCcACdTsdT
antis


 


737-756
7241
UGGGGAGAAGAAGGACGAG
7242
uGGGGAGAAGAAGGAcGAGdTsdT
sense


 


737-756
7243
CUCGUCCUUCUUCUCCCCA
7244
CUCGUCCUUCUUCUCCCcAdTsdT
antis


 


755-774
7245
GCUGUAUUUGAAUCUGGUG
7246
GcuGuAuuuGAAucuGGuGdTsdT
sense


 


755-774
7247
CACCAGAUUCAAAUACAGC
7248
cACcAGAUUcAAAuAcAGCdTsdT
antis


 


756-775
7249
CUGUAUUUGAAUCUGGUGC
7250
cuGuAuuuGAAucuGGuGcdTsdT
sense


 


756-775
7251
GCACCAGAUUCAAAUACAG
7252
GcACcAGAUUcAAAuAcAGdTsdT
antis


 


758-777
7253
GUAUUUGAAUCUGGUGCUG
7254
GuAuuuGAAucuGGuGcuGdTsdT
sense


 


758-777
7255
CAGCACCAGAUUCAAAUAC
7256
cAGcACcAGAUUcAAAuACdTsdT
antis


 


761-780
7257
UUUGAAUCUGGUGCUGGAG
7258
uuuGAAucuGGuGcuGGAGdTsdT
sense


 


761-780
7259
CUCCAGCACCAGAUUCAAA
7260
CUCcAGcACcAGAUUcAAAdTsdT
antis


 


765-784
7261
AAUCUGGUGCUGGAGUAUG
7262
AAucuGGuGcuGGAGuAuGdTsdT
sense


 


765-784
7263
CAUACUCCAGCACCAGAUU
7264
cAuACUCcAGcACcAGAUUdTsdT
antis


 


769-788
7265
UGGUGCUGGAGUAUGUGCC
7266
uGGuGcuGGAGuAuGuGccdTsdT
sense


 


769-788
7267
GGCACAUACUCCAGCACCA
7268
GGcAcAuACUCcAGcACcAdTsdT
antis


 


770-789
7269
GGUGCUGGAGUAUGUGCCC
7270
GGuGcuGGAGuAuGuGcccdTsdT
sense


 


770-789
7271
GGGCACAUACUCCAGCACC
7272
GGGcAcAuACUCcAGcACCdTsdT
antis


 


771-790
7273
GUGCUGGAGUAUGUGCCCG
7274
GuGcuGGAGuAuGuGcccGdTsdT
sense


 


771-790
7275
CGGGCACAUACUCCAGCAC
7276
CGGGcAcAuACUCcAGcACdTsdT
antis


 


772-791
7277
UGCUGGAGUAUGUGCCCGA
7278
uGcuGGAGuAuGuGcccGAdTsdT
sense


 


772-791
7279
UCGGGCACAUACUCCAGCA
7280
UCGGGcAcAuACUCcAGcAdTsdT
antis


 


773-792
7281
GCUGGAGUAUGUGCCCGAG
7282
GcuGGAGuAuGuGcccGAGdTsdT
sense


 


773-792
7283
CUCGGGCACAUACUCCAGC
7284
CUCGGGcAcAuACUCcAGCdTsdT
antis


 


774-793
7285
CUGGAGUAUGUGCCCGAGA
7286
cuGGAGuAuGuGcccGAGAdTsdT
sense


 


774-793
7287
UCUCGGGCACAUACUCCAG
7288
UCUCGGGcAcAuACUCcAGdTsdT
antis


 


781-800
7289
AUGUGCCCGAGACGGUGUA
7290
AuGuGcccGAGAcGGuGuAdTsdT
sense


 


781-800
7291
UACACCGUCUCGGGCACAU
7292
uAcACCGUCUCGGGcAcAUdTsdT
antis


 


782-801
7293
UGUGCCCGAGACGGUGUAC
7294
uGuGcccGAGAcGGuGuAcdTsdT
sense


 


782-801
7295
GUACACCGUCUCGGGCACA
7296
GuAcACCGUCUCGGGcAcAdTsdT
antis


 


803-822
7297
AGUGGCCCGCCACUUCACC
7298
AGuGGcccGccAcuucAccdTsdT
sense


 


803-822
7299
GGUGAAGUGGCGGGCCACU
7300
GGUGAAGUGGCGGGCcACUdTsdT
antis


 


804-823
7301
GUGGCCCGCCACUUCACCA
7302
GuGGcccGccAcuucAccAdTsdT
sense


 


804-823
7303
UGGUGAAGUGGCGGGCCAC
7304
UGGUGAAGUGGCGGGCcACdTsdT
antis


 


805-824
7305
UGGCCCGCCACUUCACCAA
7306
uGGcccGccAcuucAccAAdTsdT
sense


 


805-824
7307
UUGGUGAAGUGGCGGGCCA
7308
UUGGUGAAGUGGCGGGCcAdTsdT
antis


 


806-825
7309
GGCCCGCCACUUCACCAAG
7310
GGcccGccAcuucAccAAGdTsdT
sense


 


806-825
7311
CUUGGUGAAGUGGCGGGCC
7312
CUUGGUGAAGUGGCGGGCCdTsdT
antis


 


807-826
7313
GCCCGCCACUUCACCAAGG
7314
GcccGccAcuucAccAAGGdTsdT
sense


 


807-826
7315
CCUUGGUGAAGUGGCGGGC
7316
CCUUGGUGAAGUGGCGGGCdTsdT
antis


 


808-827
7317
CCCGCCACUUCACCAAGGC
7318
cccGccAcuucAccAAGGcdTsdT
sense


 


808-827
7319
GCCUUGGUGAAGUGGCGGG
7320
GCCUUGGUGAAGUGGCGGGdTsdT
antis


 


809-828
7321
CCGCCACUUCACCAAGGCC
7322
ccGccAcuucAccAAGGccdTsdT
sense


 


809-828
7323
GGCCUUGGUGAAGUGGCGG
7324
GGCCUUGGUGAAGUGGCGGdTsdT
antis


 


810-829
7325
CGCCACUUCACCAAGGCCA
7326
cGccAcuucAccAAGGccAdTsdT
sense


 


810-829
7327
UGGCCUUGGUGAAGUGGCG
7328
UGGCCUUGGUGAAGUGGCGdTsdT
antis


 


811-830
7329
GCCACUUCACCAAGGCCAA
7330
GccAcuucAccAAGGccAAdTsdT
sense


 


811-830
7331
UUGGCCUUGGUGAAGUGGC
7332
UUGGCCUUGGUGAAGUGGCdTsdT
antis


 


813-832
7333
CACUUCACCAAGGCCAAGC
7334
cAcuucAccAAGGccAAGcdTsdT
sense


 


813-832
7335
GCUUGGCCUUGGUGAAGUG
7336
GCUUGGCCUUGGUGAAGUGdTsdT
antis


 


815-834
7337
CUUCACCAAGGCCAAGCUG
7338
cuucAccAAGGccAAGcuGdTsdT
sense


 


815-834
7339
CAGCUUGGCCUUGGUGAAG
7340
cAGCUUGGCCUUGGUGAAGdTsdT
antis


 


817-836
7341
UCACCAAGGCCAAGCUGAU
7342
ucAccAAGGccAAGcuGAudTsdT
sense


 


817-836
7343
AUCAGCUUGGCCUUGGUGA
7344
AUcAGCUUGGCCUUGGUGAdTsdT
antis


 


858-877
7345
GUGUACAUGUACCAGCUCU
7346
GuGuAcAuGuAccAGcucudTsdT
sense


 


858-877
7347
AGAGCUGGUACAUGUACAC
7348
AGAGCUGGuAcAUGuAcACdTsdT
antis


 


860-879
7349
GUACAUGUACCAGCUCUUC
7350
GuAcAuGuAccAGcucuucdTsdT
sense


 


860-879
7351
GAAGAGCUGGUACAUGUAC
7352
GAAGAGCUGGuAcAUGuACdTsdT
antis


 


861-880
7353
UACAUGUACCAGCUCUUCC
7354
uAcAuGuAccAGcucuuccdTsdT
sense


 


861-880
7355
GGAAGAGCUGGUACAUGUA
7356
GGAAGAGCUGGuAcAUGuAdTsdT
antis


 


862-881
7357
ACAUGUACCAGCUCUUCCG
7358
AcAuGuAccAGcucuuccGdTsdT
sense


 


862-881
7359
CGGAAGAGCUGGUACAUGU
7360
CGGAAGAGCUGGuAcAUGUdTsdT
antis


 


863-882
7361
CAUGUACCAGCUCUUCCGG
7362
cAuGuAccAGcucuuccGGdTsdT
sense


 


863-882
7363
CCGGAAGAGCUGGUACAUG
7364
CCGGAAGAGCUGGuAcAUGdTsdT
antis


 


865-884
7365
UGUACCAGCUCUUCCGGAG
7366
uGuAccAGcucuuccGGAGdTsdT
sense


 


865-884
7367
CUCCGGAAGAGCUGGUACA
7368
CUCCGGAAGAGCUGGuAcAdTsdT
antis


 


866-885
7369
GUACCAGCUCUUCCGGAGC
7370
GuAccAGcucuuccGGAGcdTsdT
sense


 


866-885
7371
GCUCCGGAAGAGCUGGUAC
7372
GCUCCGGAAGAGCUGGuACdTsdT
antis


 


867-886
7373
UACCAGCUCUUCCGGAGCU
7374
uAccAGcucuuccGGAGcudTsdT
sense


 


867-886
7375
AGCUCCGGAAGAGCUGGUA
7376
AGCUCCGGAAGAGCUGGuAdTsdT
antis


 


868-887
7377
ACCAGCUCUUCCGGAGCUU
7378
AccAGcucuuccGGAGcuudTsdT
sense


 


868-887
7379
AAGCUCCGGAAGAGCUGGU
7380
AAGCUCCGGAAGAGCUGGUdTsdT
antis


 


869-888
7381
CCAGCUCUUCCGGAGCUUG
7382
ccAGcucuuccGGAGcuuGdTsdT
sense


 


869-888
7383
CAAGCUCCGGAAGAGCUGG
7384
cAAGCUCCGGAAGAGCUGGdTsdT
antis


 


870-889
7385
CAGCUCUUCCGGAGCUUGG
7386
cAGcucuuccGGAGcuuGGdTsdT
sense


 


870-889
7387
CCAAGCUCCGGAAGAGCUG
7388
CcAAGCUCCGGAAGAGCUGdTsdT
antis


 


871-890
7389
AGCUCUUCCGGAGCUUGGC
7390
AGcucuuccGGAGcuuGGcdTsdT
sense


 


871-890
7391
GCCAAGCUCCGGAAGAGCU
7392
GCcAAGCUCCGGAAGAGCUdTsdT
antis


 


872-891
7393
GCUCUUCCGGAGCUUGGCC
7394
GcucuuccGGAGcuuGGccdTsdT
sense


 


872-891
7395
GGCCAAGCUCCGGAAGAGC
7396
GGCcAAGCUCCGGAAGAGCdTsdT
antis


 


874-893
7397
UCUUCCGGAGCUUGGCCUA
7398
ucuuccGGAGcuuGGccuAdTsdT
sense


 


874-893
7399
UAGGCCAAGCUCCGGAAGA
7400
uAGGCcAAGCUCCGGAAGAdTsdT
antis


 


876-895
7401
UUCCGGAGCUUGGCCUACA
7402
uuccGGAGcuuGGccuAcAdTsdT
sense


 


876-895
7403
UGUAGGCCAAGCUCCGGAA
7404
UGuAGGCcAAGCUCCGGAAdTsdT
antis


 


877-896
7405
UCCGGAGCUUGGCCUACAU
7406
uccGGAGcuuGGccuAcAudTsdT
sense


 


877-896
7407
AUGUAGGCCAAGCUCCGGA
7408
AUGuAGGCcAAGCUCCGGAdTsdT
antis


 


878-897
7409
CCGGAGCUUGGCCUACAUC
7410
ccGGAGcuuGGccuAcAucdTsdT
sense


 


878-897
7411
GAUGUAGGCCAAGCUCCGG
7412
GAUGuAGGCcAAGCUCCGGdTsdT
antis


 


911-930
7413
GUGUCACCGUGACAUCAAG
7414
GuGucAccGuGAcAucAAGdTsdT
sense


 


911-930
7415
CUUGAUGUCACGGUGACAC
7416
CUUGAUGUcACGGUGAcACdTsdT
antis


 


935-954
7417
GAAUUUGCUUGUGGACCCU
7418
GAAuuuGcuuGuGGAcccudTsdT
sense


 


935-954
7419
AGGGUCCACAAGCAAAUUC
7420
AGGGUCcAcAAGcAAAUUCdTsdT
antis


 


939-958
7421
UUGCUUGUGGACCCUGACA
7422
uuGcuuGuGGAcccuGAcAdTsdT
sense


 


939-958
7423
UGUCAGGGUCCACAAGCAA
7424
UGUcAGGGUCcAcAAGcAAdTsdT
antis


 


940-959
7425
UGCUUGUGGACCCUGACAC
7426
uGcuuGuGGAcccuGAcAcdTsdT
sense


 


940-959
7427
GUGUCAGGGUCCACAAGCA
7428
GUGUcAGGGUCcAcAAGcAdTsdT
antis


 


941-960
7429
GCUUGUGGACCCUGACACU
7430
GcuuGuGGAcccuGAcAcudTsdT
sense


 


941-960
7431
AGUGUCAGGGUCCACAAGC
7432
AGUGUcAGGGUCcAcAAGCdTsdT
antis


 


943-962
7433
UUGUGGACCCUGACACUGC
7434
uuGuGGAcccuGAcAcuGcdTsdT
sense


 


943-962
7435
GCAGUGUCAGGGUCCACAA
7436
GcAGUGUcAGGGUCcAcAAdTsdT
antis


 


949-968
7437
ACCCUGACACUGCUGUCCU
7438
AcccuGAcAcuGcuGuccudTsdT
sense


 


949-968
7439
AGGACAGCAGUGUCAGGGU
7440
AGGAcAGcAGUGUcAGGGUdTsdT
antis


 


952-971
7441
CUGACACUGCUGUCCUCAA
7442
cuGAcAcuGcuGuccucAAdTsdT
sense


 


952-971
7443
UUGAGGACAGCAGUGUCAG
7444
UUGAGGAcAGcAGUGUcAGdTsdT
antis


 


970-989
7445
AGCUCUGCGAUUUUGGCAG
7446
AGcucuGcGAuuuuGGcAGdTsdT
sense


 


970-989
7447
CUGCCAAAAUCGCAGAGCU
7448
CUGCcAAAAUCGcAGAGCUdTsdT
antis


 


974-993
7449
CUGCGAUUUUGGCAGUGCA
7450
cuGcGAuuuuGGcAGuGcAdTsdT
sense


 


974-993
7451
UGCACUGCCAAAAUCGCAG
7452
UGcACUGCcAAAAUCGcAGdTsdT
antis


 


977-996
7453
CGAUUUUGGCAGUGCAAAG
7454
cGAuuuuGGcAGuGcAAAGdTsdT
sense


 


977-996
7455
CUUUGCACUGCCAAAAUCG
7456
CUUUGcACUGCcAAAAUCGdTsdT
antis


 


978-997
7457
GAUUUUGGCAGUGCAAAGC
7458
GAuuuuGGcAGuGcAAAGcdTsdT
sense


 


978-997
7459
GCUUUGCACUGCCAAAAUC
7460
GCUUUGcACUGCcAAAAUCdTsdT
antis


 


 986-1005
7461
CAGUGCAAAGCAGCUGGUU
7462
cAGuGcAAAGcAGcuGGuudTsdT
sense


 


 986-1005
7463
AACCAGCUGCUUUGCACUG
7464
AACcAGCUGCUUUGcACUGdTsdT
antis


 


 987-1006
7465
AGUGCAAAGCAGCUGGUUC
7466
AGuGcAAAGcAGcuGGuucdTsdT
sense


 


 987-1006
7467
GAACCAGCUGCUUUGCACU
7468
GAACcAGCUGCUUUGcACUdTsdT
antis


 


 988-1007
7469
GUGCAAAGCAGCUGGUUCG
7470
GuGcAAAGcAGcuGGuucGdTsdT
sense


 


 988-1007
7471
CGAACCAGCUGCUUUGCAC
7472
CGAACcAGCUGCUUUGcACdTsdT
antis


 


1162-1181
7473
GUGGGGUGGACCAGCUUGU
7474
GuGGGGuGGAccAGcuuGudTsdT
sense


 


1162-1181
7475
ACAAGCUGGUCCACCCCAC
7476
AcAAGCUGGUCcACCCcACdTsdT
antis


 


1163-1182
7477
UGGGGUGGACCAGCUUGUG
7478
uGGGGuGGAccAGcuuGuGdTsdT
sense


 


1163-1182
7479
CACAAGCUGGUCCACCCCA
7480
cAcAAGCUGGUCcACCCcAdTsdT
antis


 


1164-1183
7481
GGGGUGGACCAGCUUGUGG
7482
GGGGuGGAccAGcuuGuGGdTsdT
sense


 


1164-1183
7483
CCACAAGCUGGUCCACCCC
7484
CcAcAAGCUGGUCcACCCCdTsdT
antis


 


1165-1184
7485
GGGUGGACCAGCUUGUGGA
7486
GGGuGGAccAGcuuGuGGAdTsdT
sense


 


1165-1184
7487
UCCACAAGCUGGUCCACCC
7488
UCcAcAAGCUGGUCcACCCdTsdT
antis


 


1168-1187
7489
UGGACCAGCUUGUGGAGAU
7490
uGGAccAGcuuGuGGAGAudTsdT
sense


 


1168-1187
7491
AUCUCCACAAGCUGGUCCA
7492
AUCUCcAcAAGCUGGUCcAdTsdT
antis


 


1172-1191
7493
CCAGCUUGUGGAGAUCAUC
7494
ccAGcuuGuGGAGAucAucdTsdT
sense


 


1172-1191
7495
GAUGAUCUCCACAAGCUGG
7496
GAUGAUCUCcAcAAGCUGGdTsdT
antis


 


1173-1192
7497
CAGCUUGUGGAGAUCAUCA
7498
cAGcuuGuGGAGAucAucAdTsdT
sense


 


1173-1192
7499
UGAUGAUCUCCACAAGCUG
7500
UGAUGAUCUCcAcAAGCUGdTsdT
antis


 


1175-1194
7501
GCUUGUGGAGAUCAUCAAG
7502
GcuuGuGGAGAucAucAAGdTsdT
sense


 


1175-1194
7503
CUUGAUGAUCUCCACAAGC
7504
CUUGAUGAUCUCcAcAAGCdTsdT
antis


 


1176-1195
7505
CUUGUGGAGAUCAUCAAGG
7506
cuuGuGGAGAucAucAAGGdTsdT
sense


 


1176-1195
7507
CCUUGAUGAUCUCCACAAG
7508
CCUUGAUGAUCUCcAcAAGdTsdT
antis


 


1177-1196
7509
UUGUGGAGAUCAUCAAGGU
7510
uuGuGGAGAucAucAAGGudTsdT
sense


 


1177-1196
7511
ACCUUGAUGAUCUCCACAA
7512
ACCUUGAUGAUCUCcAcAAdTsdT
antis


 


1179-1198
7513
GUGGAGAUCAUCAAGGUAC
7514
GuGGAGAucAucAAGGuAcdTsdT
sense


 


1179-1198
7515
GUACCUUGAUGAUCUCCAC
7516
GuACCUUGAUGAUCUCcACdTsdT
antis


 


1180-1199
7517
UGGAGAUCAUCAAGGUACU
7518
uGGAGAucAucAAGGuAcudTsdT
sense


 


1180-1199
7519
AGUACCUUGAUGAUCUCCA
7520
AGuACCUUGAUGAUCUCcAdTsdT
antis


 


1181-1200
7521
GGAGAUCAUCAAGGUACUA
7522
GGAGAucAucAAGGuAcuAdTsdT
sense


 


1181-1200
7523
UAGUACCUUGAUGAUCUCC
7524
uAGuACCUUGAUGAUCUCCdTsdT
antis


 


1182-1201
7525
GAGAUCAUCAAGGUACUAG
7526
GAGAucAucAAGGuAcuAGdTsdT
sense


 


1182-1201
7527
CUAGUACCUUGAUGAUCUC
7528
CuAGuACCUUGAUGAUCUCdTsdT
antis


 


1184-1203
7529
GAUCAUCAAGGUACUAGGA
7530
GAucAucAAGGuAcuAGGAdTsdT
sense


 


1184-1203
7531
UCCUAGUACCUUGAUGAUC
7532
UCCuAGuACCUUGAUGAUCdTsdT
antis


 


1186-1205
7533
UCAUCAAGGUACUAGGAAC
7534
ucAucAAGGuAcuAGGAAcdTsdT
sense


 


1186-1205
7535
GUUCCUAGUACCUUGAUGA
7536
GUUCCuAGuACCUUGAUGAdTsdT
antis


 


1187-1206
7537
CAUCAAGGUACUAGGAACG
7538
cAucAAGGuAcuAGGAAcGdTsdT
sense


 


1187-1206
7539
CGUUCCUAGUACCUUGAUG
7540
CGUUCCuAGuACCUUGAUGdTsdT
antis


 


1205-1224
7541
GCCAACCAGGGAACAAAUC
7542
GccAAccAGGGAAcAAAucdTsdT
sense


 


1205-1224
7543
GAUUUGUUCCCUGGUUGGC
7544
GAUUUGUUCCCUGGUUGGCdTsdT
antis


 


1207-1226
7545
CAACCAGGGAACAAAUCCG
7546
cAAccAGGGAAcAAAuccGdTsdT
sense


 


1207-1226
7547
CGGAUUUGUUCCCUGGUUG
7548
CGGAUUUGUUCCCUGGUUGdTsdT
antis


 


1209-1228
7549
ACCAGGGAACAAAUCCGAG
7550
AccAGGGAAcAAAuccGAGdTsdT
sense


 


1209-1228
7551
CUCGGAUUUGUUCCCUGGU
7552
CUCGGAUUUGUUCCCUGGUdTsdT
antis


 


1212-1231
7553
AGGGAACAAAUCCGAGAGA
7554
AGGGAAcAAAuccGAGAGAdTsdT
sense


 


1212-1231
7555
UCUCUCGGAUUUGUUCCCU
7556
UCUCUCGGAUUUGUUCCCUdTsdT
antis


 


1214-1233
7557
GGAACAAAUCCGAGAGAUG
7558
GGAAcAAAuccGAGAGAuGdTsdT
sense


 


1214-1233
7559
CAUCUCUCGGAUUUGUUCC
7560
cAUCUCUCGGAUUUGUUCCdTsdT
antis


 


1219-1238
7561
AAAUCCGAGAGAUGAACCC
7562
AAAuccGAGAGAuGAAcccdTsdT
sense


 


1219-1238
7563
GGGUUCAUCUCUCGGAUUU
7564
GGGUUcAUCUCUCGGAUUUdTsdT
antis


 


1222-1241
7565
UCCGAGAGAUGAACCCUAA
7566
uccGAGAGAuGAAcccuAAdTsdT
sense


 


1222-1241
7567
UUAGGGUUCAUCUCUCGGA
7568
UuAGGGUUcAUCUCUCGGAdTsdT
antis


 


1223-1242
7569
CCGAGAGAUGAACCCUAAC
7570
ccGAGAGAuGAAcccuAAcdTsdT
sense


 


1223-1242
7571
GUUAGGGUUCAUCUCUCGG
7572
GUuAGGGUUcAUCUCUCGGdTsdT
antis


 


1247-1266
7573
GGAGUUCAAGUUCCCCCAG
7574
GGAGuucAAGuucccccAGdTsdT
sense


 


1247-1266
7575
CUGGGGGAACUUGAACUCC
7576
CUGGGGGAACUUGAACUCCdTsdT
antis


 


1248-1267
7577
GAGUUCAAGUUCCCCCAGA
7578
GAGuucAAGuucccccAGAdTsdT
sense


 


1248-1267
7579
UCUGGGGGAACUUGAACUC
7580
UCUGGGGGAACUUGAACUCdTsdT
antis


 


1249-1268
7581
AGUUCAAGUUCCCCCAGAU
7582
AGuucAAGuucccccAGAudTsdT
sense


 


1249-1268
7583
AUCUGGGGGAACUUGAACU
7584
AUCUGGGGGAACUUGAACUdTsdT
antis


 


1250-1269
7585
GUUCAAGUUCCCCCAGAUC
7586
GuucAAGuucccccAGAucdTsdT
sense


 


1250-1269
7587
GAUCUGGGGGAACUUGAAC
7588
GAUCUGGGGGAACUUGAACdTsdT
antis


 


1251-1270
7589
UUCAAGUUCCCCCAGAUCA
7590
uucAAGuucccccAGAucAdTsdT
sense


 


1251-1270
7591
UGAUCUGGGGGAACUUGAA
7592
UGAUCUGGGGGAACUUGAAdTsdT
antis


 


1252-1271
7593
UCAAGUUCCCCCAGAUCAA
7594
ucAAGuucccccAGAucAAdTsdT
sense


 


1252-1271
7595
UUGAUCUGGGGGAACUUGA
7596
UUGAUCUGGGGGAACUUGAdTsdT
antis


 


1253-1272
7597
CAAGUUCCCCCAGAUCAAA
7598
cAAGuucccccAGAucAAAdTsdT
sense


 


1253-1272
7599
UUUGAUCUGGGGGAACUUG
7600
UUUGAUCUGGGGGAACUUGdTsdT
antis


 


1255-1274
7601
AGUUCCCCCAGAUCAAAGC
7602
AGuucccccAGAucAAAGcdTsdT
sense


 


1255-1274
7603
GCUUUGAUCUGGGGGAACU
7604
GCUUUGAUCUGGGGGAACUdTsdT
antis


 


1257-1276
7605
UUCCCCCAGAUCAAAGCUC
7606
uucccccAGAucAAAGcucdTsdT
sense


 


1257-1276
7607
GAGCUUUGAUCUGGGGGAA
7608
GAGCUUUGAUCUGGGGGAAdTsdT
antis


 


1258-1277
7609
UCCCCCAGAUCAAAGCUCA
7610
ucccccAGAucAAAGcucAdTsdT
sense


 


1258-1277
7611
UGAGCUUUGAUCUGGGGGA
7612
UGAGCUUUGAUCUGGGGGAdTsdT
antis


 


1261-1280
7613
CCCAGAUCAAAGCUCACCC
7614
cccAGAucAAAGcucAcccdTsdT
sense


 


1261-1280
7615
GGGUGAGCUUUGAUCUGGG
7616
GGGUGAGCUUUGAUCUGGGdTsdT
antis


 


1262-1281
7617
CCAGAUCAAAGCUCACCCU
7618
ccAGAucAAAGcucAcccudTsdT
sense


 


1262-1281
7619
AGGGUGAGCUUUGAUCUGG
7620
AGGGUGAGCUUUGAUCUGGdTsdT
antis


 


1280-1299
7621
UUGGACAAAGGUGUUCAAA
7622
uuGGAcAAAGGuGuucAAAdTsdT
sense


 


1280-1299
7623
UUUGAACACCUUUGUCCAA
7624
UUUGAAcACCUUUGUCcAAdTsdT
antis


 


1282-1301
7625
GGACAAAGGUGUUCAAAUC
7626
GGAcAAAGGuGuucAAAucdTsdT
sense


 


1282-1301
7627
GAUUUGAACACCUUUGUCC
7628
GAUUUGAAcACCUUUGUCCdTsdT
antis


 


1283-1302
7629
GACAAAGGUGUUCAAAUCU
7630
GAcAAAGGuGuucAAAucudTsdT
sense


 


1283-1302
7631
AGAUUUGAACACCUUUGUC
7632
AGAUUUGAAcACCUUUGUCdTsdT
antis


 


1284-1303
7633
ACAAAGGUGUUCAAAUCUU
7634
AcAAAGGuGuucAAAucuudTsdT
sense


 


1284-1303
7635
AAGAUUUGAACACCUUUGU
7636
AAGAUUUGAAcACCUUUGUdTsdT
antis


 


1354-1373
7637
CGCCAUCCUCAAGGCUCUC
7638
cGccAuccucAAGGcucucdTsdT
sense


 


1354-1373
7639
GAGAGCCUUGAGGAUGGCG
7640
GAGAGCCUUGAGGAUGGCGdTsdT
antis


 


1361-1380
7641
CUCAAGGCUCUCCCCACUC
7642
cucAAGGcucuccccAcucdTsdT
sense


 


1361-1380
7643
GAGUGGGGAGAGCCUUGAG
7644
GAGUGGGGAGAGCCUUGAGdTsdT
antis


 


1379-1398
7645
CGAGGCUUGUGCCCACAGC
7646
cGAGGcuuGuGcccAcAGcdTsdT
sense


 


1379-1398
7647
GCUGUGGGCACAAGCCUCG
7648
GCUGUGGGcAcAAGCCUCGdTsdT
antis


 


1380-1399
7649
GAGGCUUGUGCCCACAGCU
7650
GAGGcuuGuGcccAcAGcudTsdT
sense


 


1380-1399
7651
AGCUGUGGGCACAAGCCUC
7652
AGCUGUGGGcAcAAGCCUCdTsdT
antis


 


1382-1401
7653
GGCUUGUGCCCACAGCUUC
7654
GGcuuGuGcccAcAGcuucdTsdT
sense


 


1382-1401
7655
GAAGCUGUGGGCACAAGCC
7656
GAAGCUGUGGGcAcAAGCCdTsdT
antis


 


1383-1402
7657
GCUUGUGCCCACAGCUUCU
7658
GcuuGuGcccAcAGcuucudTsdT
sense


 


1383-1402
7659
AGAAGCUGUGGGCACAAGC
7660
AGAAGCUGUGGGcAcAAGCdTsdT
antis


 


1384-1403
7661
CUUGUGCCCACAGCUUCUU
7662
cuuGuGcccAcAGcuucuudTsdT
sense


 


1384-1403
7663
AAGAAGCUGUGGGCACAAG
7664
AAGAAGCUGUGGGcAcAAGdTsdT
antis


 


1386-1405
7665
UGUGCCCACAGCUUCUUCG
7666
uGuGcccAcAGcuucuucGdTsdT
sense


 


1386-1405
7667
CGAAGAAGCUGUGGGCACA
7668
CGAAGAAGCUGUGGGcAcAdTsdT
antis


 


1424-1443
7669
AGCCCAGCUCCCCAACGAC
7670
AGcccAGcuccccAAcGAcdTsdT
sense


 


1424-1443
7671
GUCGUUGGGGAGCUGGGCU
7672
GUCGUUGGGGAGCUGGGCUdTsdT
antis


 


1425-1444
7673
GCCCAGCUCCCCAACGACC
7674
GcccAGcuccccAAcGAccdTsdT
sense


 


1425-1444
7675
GGUCGUUGGGGAGCUGGGC
7676
GGUCGUUGGGGAGCUGGGCdTsdT
antis


 


1426-1445
7677
CCCAGCUCCCCAACGACCG
7678
cccAGcuccccAAcGAccGdTsdT
sense


 


1426-1445
7679
CGGUCGUUGGGGAGCUGGG
7680
CGGUCGUUGGGGAGCUGGGdTsdT
antis


 


1427-1446
7681
CCAGCUCCCCAACGACCGC
7682
ccAGcuccccAAcGAccGcdTsdT
sense


 


1427-1446
7683
GCGGUCGUUGGGGAGCUGG
7684
GCGGUCGUUGGGGAGCUGGdTsdT
antis


 


1428-1447
7685
CAGCUCCCCAACGACCGCC
7686
cAGcuccccAAcGAccGccdTsdT
sense


 


1428-1447
7687
GGCGGUCGUUGGGGAGCUG
7688
GGCGGUCGUUGGGGAGCUGdTsdT
antis


 


1454-1473
7689
CCCCCUGUUCAACUUCAGU
7690
cccccuGuucAAcuucAGudTsdT
sense


 


1454-1473
7691
ACUGAAGUUGAACAGGGGG
7692
ACUGAAGUUGAAcAGGGGGdTsdT
antis


 


1459-1478
7693
UGUUCAACUUCAGUCCUGG
7694
uGuucAAcuucAGuccuGGdTsdT
sense


 


1459-1478
7695
CCAGGACUGAAGUUGAACA
7696
CcAGGACUGAAGUUGAAcAdTsdT
antis


 


1460-1479
7697
GUUCAACUUCAGUCCUGGU
7698
GuucAAcuucAGuccuGGudTsdT
sense


 


1460-1479
7699
ACCAGGACUGAAGUUGAAC
7700
ACcAGGACUGAAGUUGAACdTsdT
antis


 


1461-1480
7701
UUCAACUUCAGUCCUGGUG
7702
uucAAcuucAGuccuGGuGdTsdT
sense


 


1461-1480
7703
CACCAGGACUGAAGUUGAA
7704
cACcAGGACUGAAGUUGAAdTsdT
antis


 


1462-1481
7705
UCAACUUCAGUCCUGGUGA
7706
ucAAcuucAGuccuGGuGAdTsdT
sense


 


1462-1481
7707
UCACCAGGACUGAAGUUGA
7708
UcACcAGGACUGAAGUUGAdTsdT
antis


 


1463-1482
7709
CAACUUCAGUCCUGGUGAA
7710
cAAcuucAGuccuGGuGAAdTsdT
sense


 


1463-1482
7711
UUCACCAGGACUGAAGUUG
7712
UUcACcAGGACUGAAGUUGdTsdT
antis


 


1503-1522
7713
AAUGCCAUUCUCAUCCCUC
7714
AAuGccAuucucAucccucdTsdT
sense


 


1503-1522
7715
GAGGGAUGAGAAUGGCAUU
7716
GAGGGAUGAGAAUGGcAUUdTsdT
antis


 


1504-1523
7717
AUGCCAUUCUCAUCCCUCC
7718
AuGccAuucucAucccuccdTsdT
sense


 


1504-1523
7719
GGAGGGAUGAGAAUGGCAU
7720
GGAGGGAUGAGAAUGGcAUdTsdT
antis


 


1505-1524
7721
UGCCAUUCUCAUCCCUCCU
7722
uGccAuucucAucccuccudTsdT
sense


 


1505-1524
7723
AGGAGGGAUGAGAAUGGCA
7724
AGGAGGGAUGAGAAUGGcAdTsdT
antis


 


1506-1525
7725
GCCAUUCUCAUCCCUCCUC
7726
GccAuucucAucccuccucdTsdT
sense


 


1506-1525
7727
GAGGAGGGAUGAGAAUGGC
7728
GAGGAGGGAUGAGAAUGGCdTsdT
antis


 


1507-1526
7729
CCAUUCUCAUCCCUCCUCA
7730
ccAuucucAucccuccucAdTsdT
sense


 


1507-1526
7731
UGAGGAGGGAUGAGAAUGG
7732
UGAGGAGGGAUGAGAAUGGdTsdT
antis


 


1508-1527
7733
CAUUCUCAUCCCUCCUCAC
7734
cAuucucAucccuccucAcdTsdT
sense


 


1508-1527
7735
GUGAGGAGGGAUGAGAAUG
7736
GUGAGGAGGGAUGAGAAUGdTsdT
antis


 


1509-1528
7737
AUUCUCAUCCCUCCUCACU
7738
AuucucAucccuccucAcudTsdT
sense


 


1509-1528
7739
AGUGAGGAGGGAUGAGAAU
7740
AGUGAGGAGGGAUGAGAAUdTsdT
antis


 


1510-1529
7741
UUCUCAUCCCUCCUCACUU
7742
uucucAucccuccucAcuudTsdT
sense


 


1510-1529
7743
AAGUGAGGAGGGAUGAGAA
7744
AAGUGAGGAGGGAUGAGAAdTsdT
antis


 


1511-1530
7745
UCUCAUCCCUCCUCACUUG
7746
ucucAucccuccucAcuuGdTsdT
sense


 


1511-1530
7747
CAAGUGAGGAGGGAUGAGA
7748
cAAGUGAGGAGGGAUGAGAdTsdT
antis


 


1515-1534
7749
AUCCCUCCUCACUUGAGGU
7750
AucccuccucAcuuGAGGudTsdT
sense


 


1515-1534
7751
ACCUCAAGUGAGGAGGGAU
7752
ACCUcAAGUGAGGAGGGAUdTsdT
antis


 


1516-1535
7753
UCCCUCCUCACUUGAGGUC
7754
ucccuccucAcuuGAGGucdTsdT
sense


 


1516-1535
7755
GACCUCAAGUGAGGAGGGA
7756
GACCUcAAGUGAGGAGGGAdTsdT
antis


 


1520-1539
7757
UCCUCACUUGAGGUCCCCA
7758
uccucAcuuGAGGuccccAdTsdT
sense


 


1520-1539
7759
UGGGGACCUCAAGUGAGGA
7760
UGGGGACCUcAAGUGAGGAdTsdT
antis


 


1522-1541
7761
CUCACUUGAGGUCCCCAGC
7762
cucAcuuGAGGuccccAGcdTsdT
sense


 


1522-1541
7763
GCUGGGGACCUCAAGUGAG
7764
GCUGGGGACCUcAAGUGAGdTsdT
antis


 


1523-1542
7765
UCACUUGAGGUCCCCAGCA
7766
ucAcuuGAGGuccccAGcAdTsdT
sense


 


1523-1542
7767
UGCUGGGGACCUCAAGUGA
7768
UGCUGGGGACCUcAAGUGAdTsdT
antis


 


1524-1543
7769
CACUUGAGGUCCCCAGCAG
7770
cAcuuGAGGuccccAGcAGdTsdT
sense


 


1524-1543
7771
CUGCUGGGGACCUCAAGUG
7772
CUGCUGGGGACCUcAAGUGdTsdT
antis


 


1528-1547
7773
UGAGGUCCCCAGCAGGCCC
7774
uGAGGuccccAGcAGGcccdTsdT
sense


 


1528-1547
7775
GGGCCUGCUGGGGACCUCA
7776
GGGCCUGCUGGGGACCUcAdTsdT
antis


 


1529-1548
7777
GAGGUCCCCAGCAGGCCCU
7778
GAGGuccccAGcAGGcccudTsdT
sense


 


1529-1548
7779
AGGGCCUGCUGGGGACCUC
7780
AGGGCCUGCUGGGGACCUCdTsdT
antis


 


1539-1558
7781
GCAGGCCCUGCUUCUCCCC
7782
GcAGGcccuGcuucuccccdTsdT
sense


 


1539-1558
7783
GGGGAGAAGCAGGGCCUGC
7784
GGGGAGAAGcAGGGCCUGCdTsdT
antis


 


1577-1596
7785
AUCCUCACAAGCUUUAACU
7786
AuccucAcAAGcuuuAAcudTsdT
sense


 


1577-1596
7787
AGUUAAAGCUUGUGAGGAU
7788
AGUuAAAGCUUGUGAGGAUdTsdT
antis


 


1578-1597
7789
UCCUCACAAGCUUUAACUG
7790
uccucAcAAGcuuuAAcuGdTsdT
sense


 


1578-1597
7791
CAGUUAAAGCUUGUGAGGA
7792
cAGUuAAAGCUUGUGAGGAdTsdT
antis


 


1579-1598
7793
CCUCACAAGCUUUAACUGA
7794
ccucAcAAGcuuuAAcuGAdTsdT
sense


 


1579-1598
7795
UCAGUUAAAGCUUGUGAGG
7796
UcAGUuAAAGCUUGUGAGGdTsdT
antis


 


1582-1601
7797
CACAAGCUUUAACUGAAGC
7798
cAcAAGcuuuAAcuGAAGcdTsdT
sense


 


1582-1601
7799
GCUUCAGUUAAAGCUUGUG
7800
GCUUcAGUuAAAGCUUGUGdTsdT
antis


 


1587-1606
7801
GCUUUAACUGAAGCUCAGA
7802
GcuuuAAcuGAAGcucAGAdTsdT
sense


 


1587-1606
7803
UCUGAGCUUCAGUUAAAGC
7804
UCUGAGCUUcAGUuAAAGCdTsdT
antis


 


1623-1642
7805
CCAUCUGAUGCCACAACUG
7806
ccAucuGAuGccAcAAcuGdTsdT
sense


 


1623-1642
7807
CAGUUGUGGCAUCAGAUGG
7808
cAGUUGUGGcAUcAGAUGGdTsdT
antis


 


1624-1643
7809
CAUCUGAUGCCACAACUGC
7810
cAucuGAuGccAcAAcuGcdTsdT
sense


 


1624-1643
7811
GCAGUUGUGGCAUCAGAUG
7812
GcAGUUGUGGcAUcAGAUGdTsdT
antis


 


1625-1644
7813
AUCUGAUGCCACAACUGCU
7814
AucuGAuGccAcAAcuGcudTsdT
sense


 


1625-1644
7815
AGCAGUUGUGGCAUCAGAU
7816
AGcAGUUGUGGcAUcAGAUdTsdT
antis


 


1630-1649
7817
AUGCCACAACUGCUACCCU
7818
AuGccAcAAcuGcuAcccudTsdT
sense


 


1630-1649
7819
AGGGUAGCAGUUGUGGCAU
7820
AGGGuAGcAGUUGUGGcAUdTsdT
antis


 


1631-1650
7821
UGCCACAACUGCUACCCUC
7822
uGccAcAAcuGcuAcccucdTsdT
sense


 


1631-1650
7823
GAGGGUAGCAGUUGUGGCA
7824
GAGGGuAGcAGUUGUGGcAdTsdT
antis


 


1632-1651
7825
GCCACAACUGCUACCCUCG
7826
GccAcAAcuGcuAcccucGdTsdT
sense


 


1632-1651
7827
CGAGGGUAGCAGUUGUGGC
7828
CGAGGGuAGcAGUUGUGGCdTsdT
antis


 


1633-1652
7829
CCACAACUGCUACCCUCGC
7830
ccAcAAcuGcuAcccucGcdTsdT
sense


 


1633-1652
7831
GCGAGGGUAGCAGUUGUGG
7832
GCGAGGGuAGcAGUUGUGGdTsdT
antis


 


1668-1687
7833
CCCCACCGACUACCCCUCC
7834
ccccAccGAcuAccccuccdTsdT
sense


 


1668-1687
7835
GGAGGGGUAGUCGGUGGGG
7836
GGAGGGGuAGUCGGUGGGGdTsdT
antis


 


1678-1697
7837
UACCCCUCCACGUCCAUCU
7838
uAccccuccAcGuccAucudTsdT
sense


 


1678-1697
7839
AGAUGGACGUGGAGGGGUA
7840
AGAUGGACGUGGAGGGGuAdTsdT
antis


 


1681-1700
7841
CCCUCCACGUCCAUCUGGG
7842
cccuccAcGuccAucuGGGdTsdT
sense


 


1681-1700
7843
CCCAGAUGGACGUGGAGGG
7844
CCcAGAUGGACGUGGAGGGdTsdT
antis


 


1683-1702
7845
CUCCACGUCCAUCUGGGAA
7846
cuccAcGuccAucuGGGAAdTsdT
sense


 


1683-1702
7847
UUCCCAGAUGGACGUGGAG
7848
UUCCcAGAUGGACGUGGAGdTsdT
antis


 


1690-1709
7849
UCCAUCUGGGAAGGCCCAA
7850
uccAucuGGGAAGGcccAAdTsdT
sense


 


1690-1709
7851
UUGGGCCUUCCCAGAUGGA
7852
UUGGGCCUUCCcAGAUGGAdTsdT
antis


 


1691-1710
7853
CCAUCUGGGAAGGCCCAAG
7854
ccAucuGGGAAGGcccAAGdTsdT
sense


 


1691-1710
7855
CUUGGGCCUUCCCAGAUGG
7856
CUUGGGCCUUCCcAGAUGGdTsdT
antis


 


1692-1711
7857
CAUCUGGGAAGGCCCAAGU
7858
cAucuGGGAAGGcccAAGudTsdT
sense


 


1692-1711
7859
ACUUGGGCCUUCCCAGAUG
7860
ACUUGGGCCUUCCcAGAUGdTsdT
antis


 


1693-1712
7861
AUCUGGGAAGGCCCAAGUG
7862
AucuGGGAAGGcccAAGuGdTsdT
sense


 


1693-1712
7863
CACUUGGGCCUUCCCAGAU
7864
cACUUGGGCCUUCCcAGAUdTsdT
antis


 


1696-1715
7865
UGGGAAGGCCCAAGUGGCG
7866
uGGGAAGGcccAAGuGGcGdTsdT
sense


 


1696-1715
7867
CGCCACUUGGGCCUUCCCA
7868
CGCcACUUGGGCCUUCCcAdTsdT
antis


 


1697-1716
7869
GGGAAGGCCCAAGUGGCGC
7870
GGGAAGGcccAAGuGGcGcdTsdT
sense


 


1697-1716
7871
GCGCCACUUGGGCCUUCCC
7872
GCGCcACUUGGGCCUUCCCdTsdT
antis


 


1698-1717
7873
GGAAGGCCCAAGUGGCGCU
7874
GGAAGGcccAAGuGGcGcudTsdT
sense


 


1698-1717
7875
AGCGCCACUUGGGCCUUCC
7876
AGCGCcACUUGGGCCUUCCdTsdT
antis


 


1699-1718
7877
GAAGGCCCAAGUGGCGCUG
7878
GAAGGcccAAGuGGcGcuGdTsdT
sense


 


1699-1718
7879
CAGCGCCACUUGGGCCUUC
7880
cAGCGCcACUUGGGCCUUCdTsdT
antis


 


1700-1719
7881
AAGGCCCAAGUGGCGCUGG
7882
AAGGcccAAGuGGcGcuGGdTsdT
sense


 


1700-1719
7883
CCAGCGCCACUUGGGCCUU
7884
CcAGCGCcACUUGGGCCUUdTsdT
antis


 


1701-1720
7885
AGGCCCAAGUGGCGCUGGG
7886
AGGcccAAGuGGcGcuGGGdTsdT
sense


 


1701-1720
7887
CCCAGCGCCACUUGGGCCU
7888
CCcAGCGCcACUUGGGCCUdTsdT
antis


 


1702-1721
7889
GGCCCAAGUGGCGCUGGGA
7890
GGcccAAGuGGcGcuGGGAdTsdT
sense


 


1702-1721
7891
UCCCAGCGCCACUUGGGCC
7892
UCCcAGCGCcACUUGGGCCdTsdT
antis


 


1707-1726
7893
AAGUGGCGCUGGGAAGGGG
7894
AAGuGGcGcuGGGAAGGGGdTsdT
sense


 


1707-1726
7895
CCCCUUCCCAGCGCCACUU
7896
CCCCUUCCcAGCGCcACUUdTsdT
antis


 


1708-1727
7897
AGUGGCGCUGGGAAGGGGG
7898
AGuGGcGcuGGGAAGGGGGdTsdT
sense


 


1708-1727
7899
CCCCCUUCCCAGCGCCACU
7900
CCCCCUUCCcAGCGCcACUdTsdT
antis


 


1712-1731
7901
GCGCUGGGAAGGGGGCCAC
7902
GcGcuGGGAAGGGGGccAcdTsdT
sense


 


1712-1731
7903
GUGGCCCCCUUCCCAGCGC
7904
GUGGCCCCCUUCCcAGCGCdTsdT
antis


 


1713-1732
7905
CGCUGGGAAGGGGGCCACA
7906
cGcuGGGAAGGGGGccAcAdTsdT
sense


 


1713-1732
7907
UGUGGCCCCCUUCCCAGCG
7908
UGUGGCCCCCUUCCcAGCGdTsdT
antis


 


1715-1734
7909
CUGGGAAGGGGGCCACAGC
7910
cuGGGAAGGGGGccAcAGcdTsdT
sense


 


1715-1734
7911
GCUGUGGCCCCCUUCCCAG
7912
GCUGUGGCCCCCUUCCcAGdTsdT
antis


 


1716-1735
7913
UGGGAAGGGGGCCACAGCC
7914
uGGGAAGGGGGccAcAGccdTsdT
sense


 


1716-1735
7915
GGCUGUGGCCCCCUUCCCA
7916
GGCUGUGGCCCCCUUCCcAdTsdT
antis


 


1717-1736
7917
GGGAAGGGGGCCACAGCCC
7918
GGGAAGGGGGccAcAGcccdTsdT
sense


 


1717-1736
7919
GGGCUGUGGCCCCCUUCCC
7920
GGGCUGUGGCCCCCUUCCCdTsdT
antis


 


1718-1737
7921
GGAAGGGGGCCACAGCCCA
7922
GGAAGGGGGccAcAGcccAdTsdT
sense


 


1718-1737
7923
UGGGCUGUGGCCCCCUUCC
7924
UGGGCUGUGGCCCCCUUCCdTsdT
antis


 


1719-1738
7925
GAAGGGGGCCACAGCCCAU
7926
GAAGGGGGccAcAGcccAudTsdT
sense


 


1719-1738
7927
AUGGGCUGUGGCCCCCUUC
7928
AUGGGCUGUGGCCCCCUUCdTsdT
antis


 


1720-1739
7929
AAGGGGGCCACAGCCCAUC
7930
AAGGGGGccAcAGcccAucdTsdT
sense


 


1720-1739
7931
GAUGGGCUGUGGCCCCCUU
7932
GAUGGGCUGUGGCCCCCUUdTsdT
antis


 


1721-1740
7933
AGGGGGCCACAGCCCAUCA
7934
AGGGGGccAcAGcccAucAdTsdT
sense


 


1721-1740
7935
UGAUGGGCUGUGGCCCCCU
7936
UGAUGGGCUGUGGCCCCCUdTsdT
antis


 


1724-1743
7937
GGGCCACAGCCCAUCAAGC
7938
GGGccAcAGcccAucAAGcdTsdT
sense


 


1724-1743
7939
GCUUGAUGGGCUGUGGCCC
7940
GCUUGAUGGGCUGUGGCCCdTsdT
antis


 


1725-1744
7941
GGCCACAGCCCAUCAAGCU
7942
GGccAcAGcccAucAAGcudTsdT
sense


 


1725-1744
7943
AGCUUGAUGGGCUGUGGCC
7944
AGCUUGAUGGGCUGUGGCCdTsdT
antis


 


1727-1746
7945
CCACAGCCCAUCAAGCUCC
7946
ccAcAGcccAucAAGcuccdTsdT
sense


 


1727-1746
7947
GGAGCUUGAUGGGCUGUGG
7948
GGAGCUUGAUGGGCUGUGGdTsdT
antis


 


1728-1747
7949
CACAGCCCAUCAAGCUCCU
7950
cAcAGcccAucAAGcuccudTsdT
sense


 


1728-1747
7951
AGGAGCUUGAUGGGCUGUG
7952
AGGAGCUUGAUGGGCUGUGdTsdT
antis


 


1729-1748
7953
ACAGCCCAUCAAGCUCCUG
7954
AcAGcccAucAAGcuccuGdTsdT
sense


 


1729-1748
7955
CAGGAGCUUGAUGGGCUGU
7956
cAGGAGCUUGAUGGGCUGUdTsdT
antis


 


1733-1752
7957
CCCAUCAAGCUCCUGCCCU
7958
cccAucAAGcuccuGcccudTsdT
sense


 


1733-1752
7959
AGGGCAGGAGCUUGAUGGG
7960
AGGGcAGGAGCUUGAUGGGdTsdT
antis


 


1734-1753
7961
CCAUCAAGCUCCUGCCCUG
7962
ccAucAAGcuccuGcccuGdTsdT
sense


 


1734-1753
7963
CAGGGCAGGAGCUUGAUGG
7964
cAGGGcAGGAGCUUGAUGGdTsdT
antis


 


1735-1754
7965
CAUCAAGCUCCUGCCCUGG
7966
cAucAAGcuccuGcccuGGdTsdT
sense


 


1735-1754
7967
CCAGGGCAGGAGCUUGAUG
7968
CcAGGGcAGGAGCUUGAUGdTsdT
antis


 


1736-1755
7969
AUCAAGCUCCUGCCCUGGC
7970
AucAAGcuccuGcccuGGcdTsdT
sense


 


1736-1755
7971
GCCAGGGCAGGAGCUUGAU
7972
GCcAGGGcAGGAGCUUGAUdTsdT
antis


 


1738-1757
7973
CAAGCUCCUGCCCUGGCUG
7974
cAAGcuccuGcccuGGcuGdTsdT
sense


 


1738-1757
7975
CAGCCAGGGCAGGAGCUUG
7976
cAGCcAGGGcAGGAGCUUGdTsdT
antis


 


1739-1758
7977
AAGCUCCUGCCCUGGCUGG
7978
AAGcuccuGcccuGGcuGGdTsdT
sense


 


1739-1758
7979
CCAGCCAGGGCAGGAGCUU
7980
CcAGCcAGGGcAGGAGCUUdTsdT
antis


 


1742-1761
7981
CUCCUGCCCUGGCUGGGCC
7982
cuccuGcccuGGcuGGGccdTsdT
sense


 


1742-1761
7983
GGCCCAGCCAGGGCAGGAG
7984
GGCCcAGCcAGGGcAGGAGdTsdT
antis


 


1745-1764
7985
CUGCCCUGGCUGGGCCCCU
7986
cuGcccuGGcuGGGccccudTsdT
sense


 


1745-1764
7987
AGGGGCCCAGCCAGGGCAG
7988
AGGGGCCcAGCcAGGGcAGdTsdT
antis


 


1747-1766
7989
GCCCUGGCUGGGCCCCUAG
7990
GcccuGGcuGGGccccuAGdTsdT
sense


 


1747-1766
7991
CUAGGGGCCCAGCCAGGGC
7992
CuAGGGGCCcAGCcAGGGCdTsdT
antis


 


1749-1768
7993
CCUGGCUGGGCCCCUAGAC
7994
ccuGGcuGGGccccuAGAcdTsdT
sense


 


1749-1768
7995
GUCUAGGGGCCCAGCCAGG
7996
GUCuAGGGGCCcAGCcAGGdTsdT
antis


 


1750-1769
7997
CUGGCUGGGCCCCUAGACU
7998
cuGGcuGGGccccuAGAcudTsdT
sense


 


1750-1769
7999
AGUCUAGGGGCCCAGCCAG
8000
AGUCuAGGGGCCcAGCcAGdTsdT
antis


 


1751-1770
8001
UGGCUGGGCCCCUAGACUA
8002
uGGcuGGGccccuAGAcuAdTsdT
sense


 


1751-1770
8003
UAGUCUAGGGGCCCAGCCA
8004
uAGUCuAGGGGCCcAGCcAdTsdT
antis


 


1754-1773
8005
CUGGGCCCCUAGACUAGAG
8006
cuGGGccccuAGAcuAGAGdTsdT
sense


 


1754-1773
8007
CUCUAGUCUAGGGGCCCAG
8008
CUCuAGUCuAGGGGCCcAGdTsdT
antis


 


1756-1775
8009
GGGCCCCUAGACUAGAGGG
8010
GGGccccuAGAcuAGAGGGdTsdT
sense


 


1756-1775
8011
CCCUCUAGUCUAGGGGCCC
8012
CCCUCuAGUCuAGGGGCCCdTsdT
antis


 


1757-1776
8013
GGCCCCUAGACUAGAGGGC
8014
GGccccuAGAcuAGAGGGcdTsdT
sense


 


1757-1776
8015
GCCCUCUAGUCUAGGGGCC
8016
GCCCUCuAGUCuAGGGGCCdTsdT
antis


 


1762-1781
8017
CUAGACUAGAGGGCAGAGG
8018
cuAGAcuAGAGGGcAGAGGdTsdT
sense


 


1762-1781
8019
CCUCUGCCCUCUAGUCUAG
8020
CCUCUGCCCUCuAGUCuAGdTsdT
antis


 


1766-1785
8021
ACUAGAGGGCAGAGGUAAA
8022
AcuAGAGGGcAGAGGuAAAdTsdT
sense


 


1766-1785
8023
UUUACCUCUGCCCUCUAGU
8024
UUuACCUCUGCCCUCuAGUdTsdT
antis


 


1768-1787
8025
UAGAGGGCAGAGGUAAAUG
8026
uAGAGGGcAGAGGuAAAuGdTsdT
sense


 


1768-1787
8027
CAUUUACCUCUGCCCUCUA
8028
cAUUuACCUCUGCCCUCuAdTsdT
antis


 


1771-1790
8029
AGGGCAGAGGUAAAUGAAC
8030
AGGGcAGAGGuAAAuGAAcdTsdT
sense


 


1771-1790
8031
GUUCAUUUACCUCUGCCCU
8032
GUUcAUUuACCUCUGCCCUdTsdT
antis


 


1776-1795
8033
AGAGGUAAAUGAACUACCC
8034
AGAGGuAAAuGAAcuAcccdTsdT
sense


 


1776-1795
8035
GGGUAGUUCAUUUACCUCU
8036
GGGuAGUUcAUUuACCUCUdTsdT
antis


 


1783-1802
8037
AAUGAACUACCCCCAGCAU
8038
AAuGAAcuAcccccAGcAudTsdT
sense


 


1783-1802
8039
AUGCUGGGGGUAGUUCAUU
8040
AUGCUGGGGGuAGUUcAUUdTsdT
antis


 


1788-1807
8041
ACUACCCCCAGCAUCUAGG
8042
AcuAcccccAGcAucuAGGdTsdT
sense


 


1788-1807
8043
CCUAGAUGCUGGGGGUAGU
8044
CCuAGAUGCUGGGGGuAGUdTsdT
antis


 


1789-1808
8045
CUACCCCCAGCAUCUAGGC
8046
cuAcccccAGcAucuAGGcdTsdT
sense


 


1789-1808
8047
GCCUAGAUGCUGGGGGUAG
8048
GCCuAGAUGCUGGGGGuAGdTsdT
antis


 


1791-1810
8049
ACCCCCAGCAUCUAGGCCU
8050
AcccccAGcAucuAGGccudTsdT
sense


 


1791-1810
8051
AGGCCUAGAUGCUGGGGGU
8052
AGGCCuAGAUGCUGGGGGUdTsdT
antis


 


1793-1812
8053
CCCCAGCAUCUAGGCCUCC
8054
ccccAGcAucuAGGccuccdTsdT
sense


 


1793-1812
8055
GGAGGCCUAGAUGCUGGGG
8056
GGAGGCCuAGAUGCUGGGGdTsdT
antis


 


1797-1816
8057
AGCAUCUAGGCCUCCCUCA
8058
AGcAucuAGGccucccucAdTsdT
sense


 


1797-1816
8059
UGAGGGAGGCCUAGAUGCU
8060
UGAGGGAGGCCuAGAUGCUdTsdT
antis


 


1822-1841
8061
UAACCUCUGUGGUGGGCUU
8062
uAAccucuGuGGuGGGcuudTsdT
sense


 


1822-1841
8063
AAGCCCACCACAGAGGUUA
8064
AAGCCcACcAcAGAGGUuAdTsdT
antis


 


1823-1842
8065
AACCUCUGUGGUGGGCUUU
8066
AAccucuGuGGuGGGcuuudTsdT
sense


 


1823-1842
8067
AAAGCCCACCACAGAGGUU
8068
AAAGCCcACcAcAGAGGUUdTsdT
antis


 


1826-1845
8069
CUCUGUGGUGGGCUUUUUA
8070
cucuGuGGuGGGcuuuuuAdTsdT
sense


 


1826-1845
8071
UAAAAAGCCCACCACAGAG
8072
uAAAAAGCCcACcAcAGAGdTsdT
antis


 


1827-1846
8073
UCUGUGGUGGGCUUUUUAA
8074
ucuGuGGuGGGcuuuuuAAdTsdT
sense


 


1827-1846
8075
UUAAAAAGCCCACCACAGA
8076
UuAAAAAGCCcACcAcAGAdTsdT
antis


 


1828-1847
8077
CUGUGGUGGGCUUUUUAAA
8078
cuGuGGuGGGcuuuuuAAAdTsdT
sense


 


1828-1847
8079
UUUAAAAAGCCCACCACAG
8080
UUuAAAAAGCCcACcAcAGdTsdT
antis


 


1829-1848
8081
UGUGGUGGGCUUUUUAAAG
8082
uGuGGuGGGcuuuuuAAAGdTsdT
sense


 


1829-1848
8083
CUUUAAAAAGCCCACCACA
8084
CUUuAAAAAGCCcACcAcAdTsdT
antis


 


1830-1849
8085
GUGGUGGGCUUUUUAAAGA
8086
GuGGuGGGcuuuuuAAAGAdTsdT
sense


 


1830-1849
8087
UCUUUAAAAAGCCCACCAC
8088
UCUUuAAAAAGCCcACcACdTsdT
antis


 


1832-1851
8089
GGUGGGCUUUUUAAAGAGG
8090
GGuGGGcuuuuuAAAGAGGdTsdT
sense


 


1832-1851
8091
CCUCUUUAAAAAGCCCACC
8092
CCUCUUuAAAAAGCCcACCdTsdT
antis


 


1835-1854
8093
GGGCUUUUUAAAGAGGAUU
8094
GGGcuuuuuAAAGAGGAuudTsdT
sense


 


1835-1854
8095
AAUCCUCUUUAAAAAGCCC
8096
AAUCCUCUUuAAAAAGCCCdTsdT
antis


 


1836-1855
8097
GGCUUUUUAAAGAGGAUUU
8098
GGcuuuuuAAAGAGGAuuudTsdT
sense


 


1836-1855
8099
AAAUCCUCUUUAAAAAGCC
8100
AAAUCCUCUUuAAAAAGCCdTsdT
antis


 


1884-1903
8101
AAGGACGGGGUUUGGGGGU
8102
AAGGAcGGGGuuuGGGGGudTsdT
sense


 


1884-1903
8103
ACCCCCAAACCCCGUCCUU
8104
ACCCCcAAACCCCGUCCUUdTsdT
antis


 


1886-1905
8105
GGACGGGGUUUGGGGGUGU
8106
GGAcGGGGuuuGGGGGuGudTsdT
sense


 


1886-1905
8107
ACACCCCCAAACCCCGUCC
8108
AcACCCCcAAACCCCGUCCdTsdT
antis


 


1889-1908
8109
CGGGGUUUGGGGGUGUGAG
8110
cGGGGuuuGGGGGuGuGAGdTsdT
sense


 


1889-1908
8111
CUCACACCCCCAAACCCCG
8112
CUcAcACCCCcAAACCCCGdTsdT
antis


 


1890-1909
8113
GGGGUUUGGGGGUGUGAGG
8114
GGGGuuuGGGGGuGuGAGGdTsdT
sense


 


1890-1909
8115
CCUCACACCCCCAAACCCC
8116
CCUcAcACCCCcAAACCCCdTsdT
antis


 


1891-1910
8117
GGGUUUGGGGGUGUGAGGA
8118
GGGuuuGGGGGuGuGAGGAdTsdT
sense


 


1891-1910
8119
UCCUCACACCCCCAAACCC
8120
UCCUcAcACCCCcAAACCCdTsdT
antis


 


1892-1911
8121
GGUUUGGGGGUGUGAGGAC
8122
GGuuuGGGGGuGuGAGGAcdTsdT
sense


 


1892-1911
8123
GUCCUCACACCCCCAAACC
8124
GUCCUcAcACCCCcAAACCdTsdT
antis


 


1893-1912
8125
GUUUGGGGGUGUGAGGACC
8126
GuuuGGGGGuGuGAGGAccdTsdT
sense


 


1893-1912
8127
GGUCCUCACACCCCCAAAC
8128
GGUCCUcAcACCCCcAAACdTsdT
antis


 


1894-1913
8129
UUUGGGGGUGUGAGGACCU
8130
uuuGGGGGuGuGAGGAccudTsdT
sense


 


1894-1913
8131
AGGUCCUCACACCCCCAAA
8132
AGGUCCUcAcACCCCcAAAdTsdT
antis


 


1895-1914
8133
UUGGGGGUGUGAGGACCUU
8134
uuGGGGGuGuGAGGAccuudTsdT
sense


 


1895-1914
8135
AAGGUCCUCACACCCCCAA
8136
AAGGUCCUcAcACCCCcAAdTsdT
antis


 


1914-1933
8137
CUACCCCCUUGGUCCCCUC
8138
cuAcccccuuGGuccccucdTsdT
sense


 


1914-1933
8139
GAGGGGACCAAGGGGGUAG
8140
GAGGGGACcAAGGGGGuAGdTsdT
antis


 


1915-1934
8141
UACCCCCUUGGUCCCCUCC
8142
uAcccccuuGGuccccuccdTsdT
sense


 


1915-1934
8143
GGAGGGGACCAAGGGGGUA
8144
GGAGGGGACcAAGGGGGuAdTsdT
antis


 


1916-1935
8145
ACCCCCUUGGUCCCCUCCC
8146
AcccccuuGGuccccucccdTsdT
sense


 


1916-1935
8147
GGGAGGGGACCAAGGGGGU
8148
GGGAGGGGACcAAGGGGGUdTsdT
antis


 


1917-1936
8149
CCCCCUUGGUCCCCUCCCC
8150
cccccuuGGuccccuccccdTsdT
sense


 


1917-1936
8151
GGGGAGGGGACCAAGGGGG
8152
GGGGAGGGGACcAAGGGGGdTsdT
antis


 


1918-1937
8153
CCCCUUGGUCCCCUCCCCU
8154
ccccuuGGuccccuccccudTsdT
sense


 


1918-1937
8155
AGGGGAGGGGACCAAGGGG
8156
AGGGGAGGGGACcAAGGGGdTsdT
antis


 


1919-1938
8157
CCCUUGGUCCCCUCCCCUC
8158
cccuuGGuccccuccccucdTsdT
sense


 


1919-1938
8159
GAGGGGAGGGGACCAAGGG
8160
GAGGGGAGGGGACcAAGGGdTsdT
antis


 


1920-1939
8161
CCUUGGUCCCCUCCCCUCC
8162
ccuuGGuccccuccccuccdTsdT
sense


 


1920-1939
8163
GGAGGGGAGGGGACCAAGG
8164
GGAGGGGAGGGGACcAAGGdTsdT
antis


 


1921-1940
8165
CUUGGUCCCCUCCCCUCCC
8166
cuuGGuccccuccccucccdTsdT
sense


 


1921-1940
8167
GGGAGGGGAGGGGACCAAG
8168
GGGAGGGGAGGGGACcAAGdTsdT
antis


 


1922-1941
8169
UUGGUCCCCUCCCCUCCCC
8170
uuGGuccccuccccuccccdTsdT
sense


 


1922-1941
8171
GGGGAGGGGAGGGGACCAA
8172
GGGGAGGGGAGGGGACcAAdTsdT
antis


 


2116-2135
8173
UUCUUGUCCUCUGCUCCCA
8174
uucuuGuccucuGcucccAdTsdT
sense


 


2116-2135
8175
UGGGAGCAGAGGACAAGAA
8176
UGGGAGcAGAGGAcAAGAAdTsdT
antis


 


213-232
8177
GGAGGCGGCCCUGGGGGCU
8178
GGAGGcGGcccuGGGGGcudTsdT
sense


 


213-232
8179
AGCCCCCAGGGCCGCCUCC
8180
AGCCCCcAGGGCCGCCUCCdTsdT
antis


 


358-377
8181
UGGGUGGGGGCGUGGGAGC
8182
uGGGuGGGGGcGuGGGAGcdTsdT
sense


 


358-377
8183
GCUCCCACGCCCCCACCCA
8184
GCUCCcACGCCCCcACCcAdTsdT
antis


 


528-547
8185
CGUUCCCAAGAAGUGGCUU
8186
cGuucccAAGAAGuGGcuudTsdT
sense


 


528-547
8187
AAGCCACUUCUUGGGAACG
8188
AAGCcACUUCUUGGGAACGdTsdT
antis


 


559-578
8189
AAGUGAUUGGUAAUGGCUC
8190
AAGuGAuuGGuAAuGGcucdTsdT
sense


 


559-578
8191
GAGCCAUUACCAAUCACUU
8192
GAGCcAUuACcAAUcACUUdTsdT
antis


 


623-642
8193
GGUGGCCAUCAAGAAGGUU
8194
GGuGGccAucAAGAAGGuudTsdT
sense


 


623-642
8195
AACCUUCUUGAUGGCCACC
8196
AACCUUCUUGAUGGCcACCdTsdT
antis


 


630-649
8197
AUCAAGAAGGUUCUUCAGG
8198
AucAAGAAGGuucuucAGGdTsdT
sense


 


630-649
8199
CCUGAAGAACCUUCUUGAU
8200
CCUGAAGAACCUUCUUGAUdTsdT
antis


 


633-652
8201
AAGAAGGUUCUUCAGGACA
8202
AAGAAGGuucuucAGGAcAdTsdT
sense


 


633-652
8203
UGUCCUGAAGAACCUUCUU
8204
UGUCCUGAAGAACCUUCUUdTsdT
antis


 


801-820
8205
CGAGUGGCCCGCCACUUCA
8206
cGAGuGGcccGccAcuucAdTsdT
sense


 


801-820
8207
UGAAGUGGCGGGCCACUCG
8208
UGAAGUGGCGGGCcACUCGdTsdT
antis


 


859-878
8209
UGUACAUGUACCAGCUCUU
8210
uGuAcAuGuAccAGcucuudTsdT
sense


 


859-878
8211
AAGAGCUGGUACAUGUACA
8212
AAGAGCUGGuAcAUGuAcAdTsdT
antis


 


936-955
8213
AAUUUGCUUGUGGACCCUG
8214
AAuuuGcuuGuGGAcccuGdTsdT
sense


 


936-955
8215
CAGGGUCCACAAGCAAAUU
8216
cAGGGUCcAcAAGcAAAUUdTsdT
antis


 


944-963
8217
UGUGGACCCUGACACUGCU
8218
uGuGGAcccuGAcAcuGcudTsdT
sense


 


944-963
8219
AGCAGUGUCAGGGUCCACA
8220
AGcAGUGUcAGGGUCcAcAdTsdT
antis


 


960-979
8221
GCUGUCCUCAAGCUCUGCG
8222
GcuGuccucAAGcucuGcGdTsdT
sense


 


960-979
8223
CGCAGAGCUUGAGGACAGC
8224
CGcAGAGCUUGAGGAcAGCdTsdT
antis


 


966-985
8225
CUCAAGCUCUGCGAUUUUG
8226
cucAAGcucuGcGAuuuuGdTsdT
sense


 


966-985
8227
CAAAAUCGCAGAGCUUGAG
8228
cAAAAUCGcAGAGCUUGAGdTsdT
antis


 


 982-1001
8229
UUGGCAGUGCAAAGCAGCU
8230
uuGGcAGuGcAAAGcAGcudTsdT
sense


 


 982-1001
8231
AGCUGCUUUGCACUGCCAA
8232
AGCUGCUUUGcACUGCcAAdTsdT
antis


 


 983-1002
8233
UGGCAGUGCAAAGCAGCUG
8234
uGGcAGuGcAAAGcAGcuGdTsdT
sense


 


 983-1002
8235
CAGCUGCUUUGCACUGCCA
8236
cAGCUGCUUUGcACUGCcAdTsdT
antis


 


1170-1189
8237
GACCAGCUUGUGGAGAUCA
8238
GAccAGcuuGuGGAGAucAdTsdT
sense


 


1170-1189
8239
UGAUCUCCACAAGCUGGUC
8240
UGAUCUCcAcAAGCUGGUCdTsdT
antis


 


1210-1229
8241
CCAGGGAACAAAUCCGAGA
8242
ccAGGGAAcAAAuccGAGAdTsdT
sense


 


1210-1229
8243
UCUCGGAUUUGUUCCCUGG
8244
UCUCGGAUUUGUUCCCUGGdTsdT
antis


 


1521-1540
8245
CCUCACUUGAGGUCCCCAG
8246
ccucAcuuGAGGuccccAGdTsdT
sense


 


1521-1540
8247
CUGGGGACCUCAAGUGAGG
8248
CUGGGGACCUcAAGUGAGGdTsdT
antis


 


1533-1552
8249
UCCCCAGCAGGCCCUGCUU
8250
uccccAGcAGGcccuGcuudTsdT
sense


 


1533-1552
8251
AAGCAGGGCCUGCUGGGGA
8252
AAGcAGGGCCUGCUGGGGAdTsdT
antis


 


1534-1553
8253
CCCCAGCAGGCCCUGCUUC
8254
ccccAGcAGGcccuGcuucdTsdT
sense


 


1534-1553
8255
GAAGCAGGGCCUGCUGGGG
8256
GAAGcAGGGCCUGCUGGGGdTsdT
antis


 


1679-1698
8257
ACCCCUCCACGUCCAUCUG
8258
AccccuccAcGuccAucuGdTsdT
sense


 


1679-1698
8259
CAGAUGGACGUGGAGGGGU
8260
cAGAUGGACGUGGAGGGGUdTsdT
antis


 


1680-1699
8261
CCCCUCCACGUCCAUCUGG
8262
ccccuccAcGuccAucuGGdTsdT
sense


 


1680-1699
8263
CCAGAUGGACGUGGAGGGG
8264
CcAGAUGGACGUGGAGGGGdTsdT
antis


 


1684-1703
8265
UCCACGUCCAUCUGGGAAG
8266
uccAcGuccAucuGGGAAGdTsdT
sense


 


1684-1703
8267
CUUCCCAGAUGGACGUGGA
8268
CUUCCcAGAUGGACGUGGAdTsdT
antis


 


1710-1729
8269
UGGCGCUGGGAAGGGGGCC
8270
uGGcGcuGGGAAGGGGGccdTsdT
sense


 


1710-1729
8271
GGCCCCCUUCCCAGCGCCA
8272
GGCCCCCUUCCcAGCGCcAdTsdT
antis


 


1711-1730
8273
GGCGCUGGGAAGGGGGCCA
8274
GGcGcuGGGAAGGGGGccAdTsdT
sense


 


1711-1730
8275
UGGCCCCCUUCCCAGCGCC
8276
UGGCCCCCUUCCcAGCGCCdTsdT
antis


 


1726-1745
8277
GCCACAGCCCAUCAAGCUC
8278
GccAcAGcccAucAAGcucdTsdT
sense


 


1726-1745
8279
GAGCUUGAUGGGCUGUGGC
8280
GAGCUUGAUGGGCUGUGGCdTsdT
antis


 


1731-1750
8281
AGCCCAUCAAGCUCCUGCC
8282
AGcccAucAAGcuccuGccdTsdT
sense


 


1731-1750
8283
GGCAGGAGCUUGAUGGGCU
8284
GGcAGGAGCUUGAUGGGCUdTsdT
antis


 


1740-1759
8285
AGCUCCUGCCCUGGCUGGG
8286
AGcuccuGcccuGGcuGGGdTsdT
sense


 


1740-1759
8287
CCCAGCCAGGGCAGGAGCU
8288
CCcAGCcAGGGcAGGAGCUdTsdT
antis


 


1741-1760
8289
GCUCCUGCCCUGGCUGGGC
8290
GcuccuGcccuGGcuGGGcdTsdT
sense


 


1741-1760
8291
GCCCAGCCAGGGCAGGAGC
8292
GCCcAGCcAGGGcAGGAGCdTsdT
antis


 


1767-1786
8293
CUAGAGGGCAGAGGUAAAU
8294
cuAGAGGGcAGAGGuAAAudTsdT
sense


 


1767-1786
8295
AUUUACCUCUGCCCUCUAG
8296
AUUuACCUCUGCCCUCuAGdTsdT
antis


 


1772-1791
8297
GGGCAGAGGUAAAUGAACU
8298
GGGcAGAGGuAAAuGAAcudTsdT
sense


 


1772-1791
8299
AGUUCAUUUACCUCUGCCC
8300
AGUUcAUUuACCUCUGCCCdTsdT
antis


 


1775-1794
8301
CAGAGGUAAAUGAACUACC
8302
cAGAGGuAAAuGAAcuAccdTsdT
sense


 


1775-1794
8303
GGUAGUUCAUUUACCUCUG
8304
GGuAGUUcAUUuACCUCUGdTsdT
antis


 


1824-1843
8305
ACCUCUGUGGUGGGCUUUU
8306
AccucuGuGGuGGGcuuuudTsdT
sense


 


1824-1843
8307
AAAAGCCCACCACAGAGGU
8308
AAAAGCCcACcAcAGAGGUdTsdT
antis


 


1834-1853
8309
UGGGCUUUUUAAAGAGGAU
8310
uGGGcuuuuuAAAGAGGAudTsdT
sense


 


1834-1853
8311
AUCCUCUUUAAAAAGCCCA
8312
AUCCUCUUuAAAAAGCCcAdTsdT
antis


 


2015-2034
8313
UUCCCUUCCCUGGCCCCCU
8314
uucccuucccuGGcccccudTsdT
sense


 


2015-2034
8315
AGGGGGCCAGGGAAGGGAA
8316
AGGGGGCcAGGGAAGGGAAdTsdT
antis


 


69-88
8317
GGAGCCGGAGCCCGAACGG
8318
GGAGccGGAGcccGAAcGGdTsdT
sense


 


69-88
8319
CCGUUCGGGCUCCGGCUCC
8320
CCGUUCGGGCUCCGGCUCCdTsdT
antis


 


112-131
8321
CAGGGGAGGCGGCGGCAGA
8322
cAGGGGAGGcGGcGGcAGAdTsdT
sense


 


112-131
8323
UCUGCCGCCGCCUCCCCUG
8324
UCUGCCGCCGCCUCCCCUGdTsdT
antis


 


113-132
8325
AGGGGAGGCGGCGGCAGAG
8326
AGGGGAGGcGGcGGcAGAGdTsdT
sense


 


113-132
8327
CUCUGCCGCCGCCUCCCCU
8328
CUCUGCCGCCGCCUCCCCUdTsdT
antis


 


114-133
8329
GGGGAGGCGGCGGCAGAGG
8330
GGGGAGGcGGcGGcAGAGGdTsdT
sense


 


114-133
8331
CCUCUGCCGCCGCCUCCCC
8332
CCUCUGCCGCCGCCUCCCCdTsdT
antis


 


116-135
8333
GGAGGCGGCGGCAGAGGCA
8334
GGAGGcGGcGGcAGAGGcAdTsdT
sense


 


116-135
8335
UGCCUCUGCCGCCGCCUCC
8336
UGCCUCUGCCGCCGCCUCCdTsdT
antis


 


130-149
8337
AGGCAGCGGCGGGGGCAGC
8338
AGGcAGcGGcGGGGGcAGcdTsdT
sense


 


130-149
8339
GCUGCCCCCGCCGCUGCCU
8340
GCUGCCCCCGCCGCUGCCUdTsdT
antis


 


131-150
8341
GGCAGCGGCGGGGGCAGCC
8342
GGcAGcGGcGGGGGcAGccdTsdT
sense


 


131-150
8343
GGCUGCCCCCGCCGCUGCC
8344
GGCUGCCCCCGCCGCUGCCdTsdT
antis


 


166-185
8345
CGCGGCCUGGGCCUGCGCU
8346
cGcGGccuGGGccuGcGcudTsdT
sense


 


166-185
8347
AGCGCAGGCCCAGGCCGCG
8348
AGCGcAGGCCcAGGCCGCGdTsdT
antis


 


272-291
8349
CGGAGGCGGAGGUGGUGGC
8350
cGGAGGcGGAGGuGGuGGcdTsdT
sense


 


272-291
8351
GCCACCACCUCCGCCUCCG
8352
GCcACcACCUCCGCCUCCGdTsdT
antis


 


273-292
8353
GGAGGCGGAGGUGGUGGCG
8354
GGAGGcGGAGGuGGuGGcGdTsdT
sense


 


273-292
8355
CGCCACCACCUCCGCCUCC
8356
CGCcACcACCUCCGCCUCCdTsdT
antis


 


274-293
8357
GAGGCGGAGGUGGUGGCGG
8358
GAGGcGGAGGuGGuGGcGGdTsdT
sense


 


274-293
8359
CCGCCACCACCUCCGCCUC
8360
CCGCcACcACCUCCGCCUCdTsdT
antis


 


276-295
8361
GGCGGAGGUGGUGGCGGCG
8362
GGcGGAGGuGGuGGcGGcGdTsdT
sense


 


276-295
8363
CGCCGCCACCACCUCCGCC
8364
CGCCGCcACcACCUCCGCCdTsdT
antis


 


277-296
8365
GCGGAGGUGGUGGCGGCGG
8366
GcGGAGGuGGuGGcGGcGGdTsdT
sense


 


277-296
8367
CCGCCGCCACCACCUCCGC
8368
CCGCCGCcACcACCUCCGCdTsdT
antis


 


285-304
8369
GGUGGCGGCGGCCCCGGGG
8370
GGuGGcGGcGGccccGGGGdTsdT
sense


 


285-304
8371
CCCCGGGGCCGCCGCCACC
8372
CCCCGGGGCCGCCGCcACCdTsdT
antis


 


286-305
8373
GUGGCGGCGGCCCCGGGGG
8374
GuGGcGGcGGccccGGGGGdTsdT
sense


 


286-305
8375
CCCCCGGGGCCGCCGCCAC
8376
CCCCCGGGGCCGCCGCcACdTsdT
antis


 


287-306
8377
UGGCGGCGGCCCCGGGGGC
8378
uGGcGGcGGccccGGGGGcdTsdT
sense


 


287-306
8379
GCCCCCGGGGCCGCCGCCA
8380
GCCCCCGGGGCCGCCGCcAdTsdT
antis


 


288-307
8381
GGCGGCGGCCCCGGGGGCU
8382
GGcGGcGGccccGGGGGcudTsdT
sense


 


288-307
8383
AGCCCCCGGGGCCGCCGCC
8384
AGCCCCCGGGGCCGCCGCCdTsdT
antis


 


309-328
8385
GCCUCUGGCCCAGGAGGCA
8386
GccucuGGcccAGGAGGcAdTsdT
sense


 


309-328
8387
UGCCUCCUGGGCCAGAGGC
8388
UGCCUCCUGGGCcAGAGGCdTsdT
antis


 


310-329
8389
CCUCUGGCCCAGGAGGCAC
8390
ccucuGGcccAGGAGGcAcdTsdT
sense


 


310-329
8391
GUGCCUCCUGGGCCAGAGG
8392
GUGCCUCCUGGGCcAGAGGdTsdT
antis


 


312-331
8393
UCUGGCCCAGGAGGCACUG
8394
ucuGGcccAGGAGGcAcuGdTsdT
sense


 


312-331
8395
CAGUGCCUCCUGGGCCAGA
8396
cAGUGCCUCCUGGGCcAGAdTsdT
antis


 


313-332
8397
CUGGCCCAGGAGGCACUGG
8398
cuGGcccAGGAGGcAcuGGdTsdT
sense


 


313-332
8399
CCAGUGCCUCCUGGGCCAG
8400
CcAGUGCCUCCUGGGCcAGdTsdT
antis


 


315-334
8401
GGCCCAGGAGGCACUGGCG
8402
GGcccAGGAGGcAcuGGcGdTsdT
sense


 


315-334
8403
CGCCAGUGCCUCCUGGGCC
8404
CGCcAGUGCCUCCUGGGCCdTsdT
antis


 


356-375
8405
UAUGGGUGGGGGCGUGGGA
8406
uAuGGGuGGGGGcGuGGGAdTsdT
sense


 


356-375
8407
UCCCACGCCCCCACCCAUA
8408
UCCcACGCCCCcACCcAuAdTsdT
antis


 


359-378
8409
GGGUGGGGGCGUGGGAGCC
8410
GGGuGGGGGcGuGGGAGccdTsdT
sense


 


359-378
8411
GGCUCCCACGCCCCCACCC
8412
GGCUCCcACGCCCCcACCCdTsdT
antis


 


360-379
8413
GGUGGGGGCGUGGGAGCCU
8414
GGuGGGGGcGuGGGAGccudTsdT
sense


 


360-379
8415
AGGCUCCCACGCCCCCACC
8416
AGGCUCCcACGCCCCcACCdTsdT
antis


 


362-381
8417
UGGGGGCGUGGGAGCCUCG
8418
uGGGGGcGuGGGAGccucGdTsdT
sense


 


362-381
8419
CGAGGCUCCCACGCCCCCA
8420
CGAGGCUCCcACGCCCCcAdTsdT
antis


 


367-386
8421
GCGUGGGAGCCUCGAGCUC
8422
GcGuGGGAGccucGAGcucdTsdT
sense


 


367-386
8423
GAGCUCGAGGCUCCCACGC
8424
GAGCUCGAGGCUCCcACGCdTsdT
antis


 


401-420
8425
CGGCAGCGGCGGAGGAGGC
8426
cGGcAGcGGcGGAGGAGGcdTsdT
sense


 


401-420
8427
GCCUCCUCCGCCGCUGCCG
8428
GCCUCCUCCGCCGCUGCCGdTsdT
antis


 


402-421
8429
GGCAGCGGCGGAGGAGGCA
8430
GGcAGcGGcGGAGGAGGcAdTsdT
sense


 


402-421
8431
UGCCUCCUCCGCCGCUGCC
8432
UGCCUCCUCCGCCGCUGCCdTsdT
antis


 


409-428
8433
GCGGAGGAGGCAGCGGUGG
8434
GcGGAGGAGGcAGcGGuGGdTsdT
sense


 


409-428
8435
CCACCGCUGCCUCCUCCGC
8436
CcACCGCUGCCUCCUCCGCdTsdT
antis


 


410-429
8437
CGGAGGAGGCAGCGGUGGC
8438
cGGAGGAGGcAGcGGuGGcdTsdT
sense


 


410-429
8439
GCCACCGCUGCCUCCUCCG
8440
GCcACCGCUGCCUCCUCCGdTsdT
antis


 


415-434
8441
GAGGCAGCGGUGGCCCCGG
8442
GAGGcAGcGGuGGccccGGdTsdT
sense


 


415-434
8443
CCGGGGCCACCGCUGCCUC
8444
CCGGGGCcACCGCUGCCUCdTsdT
antis


 


416-435
8445
AGGCAGCGGUGGCCCCGGC
8446
AGGcAGcGGuGGccccGGcdTsdT
sense


 


416-435
8447
GCCGGGGCCACCGCUGCCU
8448
GCCGGGGCcACCGCUGCCUdTsdT
antis


 


483-502
8449
GGGAAGGUGACCACAGUGG
8450
GGGAAGGuGAccAcAGuGGdTsdT
sense


 


483-502
8451
CCACUGUGGUCACCUUCCC
8452
CcACUGUGGUcACCUUCCCdTsdT
antis


 


484-503
8453
GGAAGGUGACCACAGUGGU
8454
GGAAGGuGAccAcAGuGGudTsdT
sense


 


484-503
8455
ACCACUGUGGUCACCUUCC
8456
ACcACUGUGGUcACCUUCCdTsdT
antis


 


486-505
8457
AAGGUGACCACAGUGGUAG
8458
AAGGuGAccAcAGuGGuAGdTsdT
sense


 


486-505
8459
CUACCACUGUGGUCACCUU
8460
CuACcACUGUGGUcACCUUdTsdT
antis


 


529-548
8461
GUUCCCAAGAAGUGGCUUA
8462
GuucccAAGAAGuGGcuuAdTsdT
sense


 


529-548
8463
UAAGCCACUUCUUGGGAAC
8464
uAAGCcACUUCUUGGGAACdTsdT
antis


 


560-579
8465
AGUGAUUGGUAAUGGCUCA
8466
AGuGAuuGGuAAuGGcucAdTsdT
sense


 


560-579
8467
UGAGCCAUUACCAAUCACU
8468
UGAGCcAUuACcAAUcACUdTsdT
antis


 


561-580
8469
GUGAUUGGUAAUGGCUCAU
8470
GuGAuuGGuAAuGGcucAudTsdT
sense


 


561-580
8471
AUGAGCCAUUACCAAUCAC
8472
AUGAGCcAUuACcAAUcACdTsdT
antis


 


622-641
8473
UGGUGGCCAUCAAGAAGGU
8474
uGGuGGccAucAAGAAGGudTsdT
sense


 


622-641
8475
ACCUUCUUGAUGGCCACCA
8476
ACCUUCUUGAUGGCcACcAdTsdT
antis


 


628-647
8477
CCAUCAAGAAGGUUCUUCA
8478
ccAucAAGAAGGuucuucAdTsdT
sense


 


628-647
8479
UGAAGAACCUUCUUGAUGG
8480
UGAAGAACCUUCUUGAUGGdTsdT
antis


 


629-648
8481
CAUCAAGAAGGUUCUUCAG
8482
cAucAAGAAGGuucuucAGdTsdT
sense


 


629-648
8483
CUGAAGAACCUUCUUGAUG
8484
CUGAAGAACCUUCUUGAUGdTsdT
antis


 


637-656
8485
AGGUUCUUCAGGACAAAAG
8486
AGGuucuucAGGAcAAAAGdTsdT
sense


 


637-656
8487
CUUUUGUCCUGAAGAACCU
8488
CUUUUGUCCUGAAGAACCUdTsdT
antis


 


684-703
8489
CGUAAGCUGGACCACUGCA
8490
cGuAAGcuGGAccAcuGcAdTsdT
sense


 


684-703
8491
UGCAGUGGUCCAGCUUACG
8492
UGcAGUGGUCcAGCUuACGdTsdT
antis


 


695-714
8493
CCACUGCAAUAUUGUGAGG
8494
ccAcuGcAAuAuuGuGAGGdTsdT
sense


 


695-714
8495
CCUCACAAUAUUGCAGUGG
8496
CCUcAcAAuAUUGcAGUGGdTsdT
antis


 


719-738
8497
GUACUUUUUCUACUCCAGU
8498
GuAcuuuuucuAcuccAGudTsdT
sense


 


719-738
8499
ACUGGAGUAGAAAAAGUAC
8500
ACUGGAGuAGAAAAAGuACdTsdT
antis


 


722-741
8501
CUUUUUCUACUCCAGUGGG
8502
cuuuuucuAcuccAGuGGGdTsdT
sense


 


722-741
8503
CCCACUGGAGUAGAAAAAG
8504
CCcACUGGAGuAGAAAAAGdTsdT
antis


 


728-747
8505
CUACUCCAGUGGGGAGAAG
8506
cuAcuccAGuGGGGAGAAGdTsdT
sense


 


728-747
8507
CUUCUCCCCACUGGAGUAG
8508
CUUCUCCCcACUGGAGuAGdTsdT
antis


 


732-751
8509
UCCAGUGGGGAGAAGAAGG
8510
uccAGuGGGGAGAAGAAGGdTsdT
sense


 


732-751
8511
CCUUCUUCUCCCCACUGGA
8512
CCUUCUUCUCCCcACUGGAdTsdT
antis


 


734-753
8513
CAGUGGGGAGAAGAAGGAC
8514
cAGuGGGGAGAAGAAGGAcdTsdT
sense


 


734-753
8515
GUCCUUCUUCUCCCCACUG
8516
GUCCUUCUUCUCCCcACUGdTsdT
antis


 


735-754
8517
AGUGGGGAGAAGAAGGACG
8518
AGuGGGGAGAAGAAGGAcGdTsdT
sense


 


735-754
8519
CGUCCUUCUUCUCCCCACU
8520
CGUCCUUCUUCUCCCcACUdTsdT
antis


 


766-785
8521
AUCUGGUGCUGGAGUAUGU
8522
AucuGGuGcuGGAGuAuGudTsdT
sense


 


766-785
8523
ACAUACUCCAGCACCAGAU
8524
AcAuACUCcAGcACcAGAUdTsdT
antis


 


767-786
8525
UCUGGUGCUGGAGUAUGUG
8526
ucuGGuGcuGGAGuAuGuGdTsdT
sense


 


767-786
8527
CACAUACUCCAGCACCAGA
8528
cAcAuACUCcAGcACcAGAdTsdT
antis


 


768-787
8529
CUGGUGCUGGAGUAUGUGC
8530
cuGGuGcuGGAGuAuGuGcdTsdT
sense


 


768-787
8531
GCACAUACUCCAGCACCAG
8532
GcAcAuACUCcAGcACcAGdTsdT
antis


 


812-831
8533
CCACUUCACCAAGGCCAAG
8534
ccAcuucAccAAGGccAAGdTsdT
sense


 


812-831
8535
CUUGGCCUUGGUGAAGUGG
8536
CUUGGCCUUGGUGAAGUGGdTsdT
antis


 


814-833
8537
ACUUCACCAAGGCCAAGCU
8538
AcuucAccAAGGccAAGcudTsdT
sense


 


814-833
8539
AGCUUGGCCUUGGUGAAGU
8540
AGCUUGGCCUUGGUGAAGUdTsdT
antis


 


816-835
8541
UUCACCAAGGCCAAGCUGA
8542
uucAccAAGGccAAGcuGAdTsdT
sense


 


816-835
8543
UCAGCUUGGCCUUGGUGAA
8544
UcAGCUUGGCCUUGGUGAAdTsdT
antis


 


819-838
8545
ACCAAGGCCAAGCUGAUCA
8546
AccAAGGccAAGcuGAucAdTsdT
sense


 


819-838
8547
UGAUCAGCUUGGCCUUGGU
8548
UGAUcAGCUUGGCCUUGGUdTsdT
antis


 


820-839
8549
CCAAGGCCAAGCUGAUCAC
8550
ccAAGGccAAGcuGAucAcdTsdT
sense


 


820-839
8551
GUGAUCAGCUUGGCCUUGG
8552
GUGAUcAGCUUGGCCUUGGdTsdT
antis


 


864-883
8553
AUGUACCAGCUCUUCCGGA
8554
AuGuAccAGcucuuccGGAdTsdT
sense


 


864-883
8555
UCCGGAAGAGCUGGUACAU
8556
UCCGGAAGAGCUGGuAcAUdTsdT
antis


 


875-894
8557
CUUCCGGAGCUUGGCCUAC
8558
cuuccGGAGcuuGGccuAcdTsdT
sense


 


875-894
8559
GUAGGCCAAGCUCCGGAAG
8560
GuAGGCcAAGCUCCGGAAGdTsdT
antis


 


964-983
8561
UCCUCAAGCUCUGCGAUUU
8562
uccucAAGcucuGcGAuuudTsdT
sense


 


964-983
8563
AAAUCGCAGAGCUUGAGGA
8564
AAAUCGcAGAGCUUGAGGAdTsdT
antis


 


965-984
8565
CCUCAAGCUCUGCGAUUUU
8566
ccucAAGcucuGcGAuuuudTsdT
sense


 


965-984
8567
AAAAUCGCAGAGCUUGAGG
8568
AAAAUCGcAGAGCUUGAGGdTsdT
antis


 


969-988
8569
AAGCUCUGCGAUUUUGGCA
8570
AAGcucuGcGAuuuuGGcAdTsdT
sense


 


969-988
8571
UGCCAAAAUCGCAGAGCUU
8572
UGCcAAAAUCGcAGAGCUUdTsdT
antis


 


980-999
8573
UUUUGGCAGUGCAAAGCAG
8574
uuuuGGcAGuGcAAAGcAGdTsdT
sense


 


980-999
8575
CUGCUUUGCACUGCCAAAA
8576
CUGCUUUGcACUGCcAAAAdTsdT
antis


 


 981-1000
8577
UUUGGCAGUGCAAAGCAGC
8578
uuuGGcAGuGcAAAGcAGcdTsdT
sense


 


 981-1000
8579
GCUGCUUUGCACUGCCAAA
8580
GCUGCUUUGcACUGCcAAAdTsdT
antis


 


 985-1004
8581
GCAGUGCAAAGCAGCUGGU
8582
GcAGuGcAAAGcAGcuGGudTsdT
sense


 


 985-1004
8583
ACCAGCUGCUUUGCACUGC
8584
ACcAGCUGCUUUGcACUGCdTsdT
antis


 


1166-1185
8585
GGUGGACCAGCUUGUGGAG
8586
GGuGGAccAGcuuGuGGAGdTsdT
sense


 


1166-1185
8587
CUCCACAAGCUGGUCCACC
8588
CUCcAcAAGCUGGUCcACCdTsdT
antis


 


1167-1186
8589
GUGGACCAGCUUGUGGAGA
8590
GuGGAccAGcuuGuGGAGAdTsdT
sense


 


1167-1186
8591
UCUCCACAAGCUGGUCCAC
8592
UCUCcAcAAGCUGGUCcACdTsdT
antis


 


1171-1190
8593
ACCAGCUUGUGGAGAUCAU
8594
AccAGcuuGuGGAGAucAudTsdT
sense


 


1171-1190
8595
AUGAUCUCCACAAGCUGGU
8596
AUGAUCUCcAcAAGCUGGUdTsdT
antis


 


1211-1230
8597
CAGGGAACAAAUCCGAGAG
8598
cAGGGAAcAAAuccGAGAGdTsdT
sense


 


1211-1230
8599
CUCUCGGAUUUGUUCCCUG
8600
CUCUCGGAUUUGUUCCCUGdTsdT
antis


 


1254-1273
8601
AAGUUCCCCCAGAUCAAAG
8602
AAGuucccccAGAucAAAGdTsdT
sense


 


1254-1273
8603
CUUUGAUCUGGGGGAACUU
8604
CUUUGAUCUGGGGGAACUUdTsdT
antis


 


1259-1278
8605
CCCCCAGAUCAAAGCUCAC
8606
cccccAGAucAAAGcucAcdTsdT
sense


 


1259-1278
8607
GUGAGCUUUGAUCUGGGGG
8608
GUGAGCUUUGAUCUGGGGGdTsdT
antis


 


1260-1279
8609
CCCCAGAUCAAAGCUCACC
8610
ccccAGAucAAAGcucAccdTsdT
sense


 


1260-1279
8611
GGUGAGCUUUGAUCUGGGG
8612
GGUGAGCUUUGAUCUGGGGdTsdT
antis


 


1281-1300
8613
UGGACAAAGGUGUUCAAAU
8614
uGGAcAAAGGuGuucAAAudTsdT
sense


 


1281-1300
8615
AUUUGAACACCUUUGUCCA
8616
AUUUGAAcACCUUUGUCcAdTsdT
antis


 


1360-1379
8617
CCUCAAGGCUCUCCCCACU
8618
ccucAAGGcucuccccAcudTsdT
sense


 


1360-1379
8619
AGUGGGGAGAGCCUUGAGG
8620
AGUGGGGAGAGCCUUGAGGdTsdT
antis


 


1381-1400
8621
AGGCUUGUGCCCACAGCUU
8622
AGGcuuGuGcccAcAGcuudTsdT
sense


 


1381-1400
8623
AAGCUGUGGGCACAAGCCU
8624
AAGCUGUGGGcAcAAGCCUdTsdT
antis


 


1385-1404
8625
UUGUGCCCACAGCUUCUUC
8626
uuGuGcccAcAGcuucuucdTsdT
sense


 


1385-1404
8627
GAAGAAGCUGUGGGCACAA
8628
GAAGAAGCUGUGGGcAcAAdTsdT
antis


 


1387-1406
8629
GUGCCCACAGCUUCUUCGA
8630
GuGcccAcAGcuucuucGAdTsdT
sense


 


1387-1406
8631
UCGAAGAAGCUGUGGGCAC
8632
UCGAAGAAGCUGUGGGcACdTsdT
antis


 


1388-1407
8633
UGCCCACAGCUUCUUCGAU
8634
uGcccAcAGcuucuucGAudTsdT
sense


 


1388-1407
8635
AUCGAAGAAGCUGUGGGCA
8636
AUCGAAGAAGCUGUGGGcAdTsdT
antis


 


1455-1474
8637
CCCCUGUUCAACUUCAGUC
8638
ccccuGuucAAcuucAGucdTsdT
sense


 


1455-1474
8639
GACUGAAGUUGAACAGGGG
8640
GACUGAAGUUGAAcAGGGGdTsdT
antis


 


1456-1475
8641
CCCUGUUCAACUUCAGUCC
8642
cccuGuucAAcuucAGuccdTsdT
sense


 


1456-1475
8643
GGACUGAAGUUGAACAGGG
8644
GGACUGAAGUUGAAcAGGGdTsdT
antis


 


1457-1476
8645
CCUGUUCAACUUCAGUCCU
8646
ccuGuucAAcuucAGuccudTsdT
sense


 


1457-1476
8647
AGGACUGAAGUUGAACAGG
8648
AGGACUGAAGUUGAAcAGGdTsdT
antis


 


1458-1477
8649
CUGUUCAACUUCAGUCCUG
8650
cuGuucAAcuucAGuccuGdTsdT
sense


 


1458-1477
8651
CAGGACUGAAGUUGAACAG
8652
cAGGACUGAAGUUGAAcAGdTsdT
antis


 


1513-1532
8653
UCAUCCCUCCUCACUUGAG
8654
ucAucccuccucAcuuGAGdTsdT
sense


 


1513-1532
8655
CUCAAGUGAGGAGGGAUGA
8656
CUcAAGUGAGGAGGGAUGAdTsdT
antis


 


1514-1533
8657
CAUCCCUCCUCACUUGAGG
8658
cAucccuccucAcuuGAGGdTsdT
sense


 


1514-1533
8659
CCUCAAGUGAGGAGGGAUG
8660
CCUcAAGUGAGGAGGGAUGdTsdT
antis


 


1517-1536
8661
CCCUCCUCACUUGAGGUCC
8662
cccuccucAcuuGAGGuccdTsdT
sense


 


1517-1536
8663
GGACCUCAAGUGAGGAGGG
8664
GGACCUcAAGUGAGGAGGGdTsdT
antis


 


1518-1537
8665
CCUCCUCACUUGAGGUCCC
8666
ccuccucAcuuGAGGucccdTsdT
sense


 


1518-1537
8667
GGGACCUCAAGUGAGGAGG
8668
GGGACCUcAAGUGAGGAGGdTsdT
antis


 


1519-1538
8669
CUCCUCACUUGAGGUCCCC
8670
cuccucAcuuGAGGuccccdTsdT
sense


 


1519-1538
8671
GGGGACCUCAAGUGAGGAG
8672
GGGGACCUcAAGUGAGGAGdTsdT
antis


 


1525-1544
8673
ACUUGAGGUCCCCAGCAGG
8674
AcuuGAGGuccccAGcAGGdTsdT
sense


 


1525-1544
8675
CCUGCUGGGGACCUCAAGU
8676
CCUGCUGGGGACCUcAAGUdTsdT
antis


 


1526-1545
8677
CUUGAGGUCCCCAGCAGGC
8678
cuuGAGGuccccAGcAGGcdTsdT
sense


 


1526-1545
8679
GCCUGCUGGGGACCUCAAG
8680
GCCUGCUGGGGACCUcAAGdTsdT
antis


 


1527-1546
8681
UUGAGGUCCCCAGCAGGCC
8682
uuGAGGuccccAGcAGGccdTsdT
sense


 


1527-1546
8683
GGCCUGCUGGGGACCUCAA
8684
GGCCUGCUGGGGACCUcAAdTsdT
antis


 


1530-1549
8685
AGGUCCCCAGCAGGCCCUG
8686
AGGuccccAGcAGGcccuGdTsdT
sense


 


1530-1549
8687
CAGGGCCUGCUGGGGACCU
8688
cAGGGCCUGCUGGGGACCUdTsdT
antis


 


1531-1550
8689
GGUCCCCAGCAGGCCCUGC
8690
GGuccccAGcAGGcccuGcdTsdT
sense


 


1531-1550
8691
GCAGGGCCUGCUGGGGACC
8692
GcAGGGCCUGCUGGGGACCdTsdT
antis


 


1532-1551
8693
GUCCCCAGCAGGCCCUGCU
8694
GuccccAGcAGGcccuGcudTsdT
sense


 


1532-1551
8695
AGCAGGGCCUGCUGGGGAC
8696
AGcAGGGCCUGCUGGGGACdTsdT
antis


 


1538-1557
8697
AGCAGGCCCUGCUUCUCCC
8698
AGcAGGcccuGcuucucccdTsdT
sense


 


1538-1557
8699
GGGAGAAGCAGGGCCUGCU
8700
GGGAGAAGcAGGGCCUGCUdTsdT
antis


 


1588-1607
8701
CUUUAACUGAAGCUCAGAC
8702
cuuuAAcuGAAGcucAGAcdTsdT
sense


 


1588-1607
8703
GUCUGAGCUUCAGUUAAAG
8704
GUCUGAGCUUcAGUuAAAGdTsdT
antis


 


1626-1645
8705
UCUGAUGCCACAACUGCUA
8706
ucuGAuGccAcAAcuGcuAdTsdT
sense


 


1626-1645
8707
UAGCAGUUGUGGCAUCAGA
8708
uAGcAGUUGUGGcAUcAGAdTsdT
antis


 


1627-1646
8709
CUGAUGCCACAACUGCUAC
8710
cuGAuGccAcAAcuGcuAcdTsdT
sense


 


1627-1646
8711
GUAGCAGUUGUGGCAUCAG
8712
GuAGcAGUUGUGGcAUcAGdTsdT
antis


 


1628-1647
8713
UGAUGCCACAACUGCUACC
8714
uGAuGccAcAAcuGcuAccdTsdT
sense


 


1628-1647
8715
GGUAGCAGUUGUGGCAUCA
8716
GGuAGcAGUUGUGGcAUcAdTsdT
antis


 


1629-1648
8717
GAUGCCACAACUGCUACCC
8718
GAuGccAcAAcuGcuAcccdTsdT
sense


 


1629-1648
8719
GGGUAGCAGUUGUGGCAUC
8720
GGGuAGcAGUUGUGGcAUCdTsdT
antis


 


1686-1705
8721
CACGUCCAUCUGGGAAGGC
8722
cAcGuccAucuGGGAAGGcdTsdT
sense


 


1686-1705
8723
GCCUUCCCAGAUGGACGUG
8724
GCCUUCCcAGAUGGACGUGdTsdT
antis


 


1687-1706
8725
ACGUCCAUCUGGGAAGGCC
8726
AcGuccAucuGGGAAGGccdTsdT
sense


 


1687-1706
8727
GGCCUUCCCAGAUGGACGU
8728
GGCCUUCCcAGAUGGACGUdTsdT
antis


 


1688-1707
8729
CGUCCAUCUGGGAAGGCCC
8730
cGuccAucuGGGAAGGcccdTsdT
sense


 


1688-1707
8731
GGGCCUUCCCAGAUGGACG
8732
GGGCCUUCCcAGAUGGACGdTsdT
antis


 


1689-1708
8733
GUCCAUCUGGGAAGGCCCA
8734
GuccAucuGGGAAGGcccAdTsdT
sense


 


1689-1708
8735
UGGGCCUUCCCAGAUGGAC
8736
UGGGCCUUCCcAGAUGGACdTsdT
antis


 


1694-1713
8737
UCUGGGAAGGCCCAAGUGG
8738
ucuGGGAAGGcccAAGuGGdTsdT
sense


 


1694-1713
8739
CCACUUGGGCCUUCCCAGA
8740
CcACUUGGGCCUUCCcAGAdTsdT
antis


 


1695-1714
8741
CUGGGAAGGCCCAAGUGGC
8742
cuGGGAAGGcccAAGuGGcdTsdT
sense


 


1695-1714
8743
GCCACUUGGGCCUUCCCAG
8744
GCcACUUGGGCCUUCCcAGdTsdT
antis


 


1709-1728
8745
GUGGCGCUGGGAAGGGGGC
8746
GuGGcGcuGGGAAGGGGGcdTsdT
sense


 


1709-1728
8747
GCCCCCUUCCCAGCGCCAC
8748
GCCCCCUUCCcAGCGCcACdTsdT
antis


 


1714-1733
8749
GCUGGGAAGGGGGCCACAG
8750
GcuGGGAAGGGGGccAcAGdTsdT
sense


 


1714-1733
8751
CUGUGGCCCCCUUCCCAGC
8752
CUGUGGCCCCCUUCCcAGCdTsdT
antis


 


1722-1741
8753
GGGGGCCACAGCCCAUCAA
8754
GGGGGccAcAGcccAucAAdTsdT
sense


 


1722-1741
8755
UUGAUGGGCUGUGGCCCCC
8756
UUGAUGGGCUGUGGCCCCCdTsdT
antis


 


1723-1742
8757
GGGGCCACAGCCCAUCAAG
8758
GGGGccAcAGcccAucAAGdTsdT
sense


 


1723-1742
8759
CUUGAUGGGCUGUGGCCCC
8760
CUUGAUGGGCUGUGGCCCCdTsdT
antis


 


1732-1751
8761
GCCCAUCAAGCUCCUGCCC
8762
GcccAucAAGcuccuGcccdTsdT
sense


 


1732-1751
8763
GGGCAGGAGCUUGAUGGGC
8764
GGGcAGGAGCUUGAUGGGCdTsdT
antis


 


1737-1756
8765
UCAAGCUCCUGCCCUGGCU
8766
ucAAGcuccuGcccuGGcudTsdT
sense


 


1737-1756
8767
AGCCAGGGCAGGAGCUUGA
8768
AGCcAGGGcAGGAGCUUGAdTsdT
antis


 


1743-1762
8769
UCCUGCCCUGGCUGGGCCC
8770
uccuGcccuGGcuGGGcccdTsdT
sense


 


1743-1762
8771
GGGCCCAGCCAGGGCAGGA
8772
GGGCCcAGCcAGGGcAGGAdTsdT
antis


 


1744-1763
8773
CCUGCCCUGGCUGGGCCCC
8774
ccuGcccuGGcuGGGccccdTsdT
sense


 


1744-1763
8775
GGGGCCCAGCCAGGGCAGG
8776
GGGGCCcAGCcAGGGcAGGdTsdT
antis


 


1746-1765
8777
UGCCCUGGCUGGGCCCCUA
8778
uGcccuGGcuGGGccccuAdTsdT
sense


 


1746-1765
8779
UAGGGGCCCAGCCAGGGCA
8780
uAGGGGCCcAGCcAGGGcAdTsdT
antis


 


1748-1767
8781
CCCUGGCUGGGCCCCUAGA
8782
cccuGGcuGGGccccuAGAdTsdT
sense


 


1748-1767
8783
UCUAGGGGCCCAGCCAGGG
8784
UCuAGGGGCCcAGCcAGGGdTsdT
antis


 


1769-1788
8785
AGAGGGCAGAGGUAAAUGA
8786
AGAGGGcAGAGGuAAAuGAdTsdT
sense


 


1769-1788
8787
UCAUUUACCUCUGCCCUCU
8788
UcAUUuACCUCUGCCCUCUdTsdT
antis


 


1770-1789
8789
GAGGGCAGAGGUAAAUGAA
8790
GAGGGcAGAGGuAAAuGAAdTsdT
sense


 


1770-1789
8791
UUCAUUUACCUCUGCCCUC
8792
UUcAUUuACCUCUGCCCUCdTsdT
antis


 


1798-1817
8793
GCAUCUAGGCCUCCCUCAG
8794
GcAucuAGGccucccucAGdTsdT
sense


 


1798-1817
8795
CUGAGGGAGGCCUAGAUGC
8796
CUGAGGGAGGCCuAGAUGCdTsdT
antis


 


1825-1844
8797
CCUCUGUGGUGGGCUUUUU
8798
ccucuGuGGuGGGcuuuuudTsdT
sense


 


1825-1844
8799
AAAAAGCCCACCACAGAGG
8800
AAAAAGCCcACcAcAGAGGdTsdT
antis


 


1831-1850
8801
UGGUGGGCUUUUUAAAGAG
8802
uGGuGGGcuuuuuAAAGAGdTsdT
sense


 


1831-1850
8803
CUCUUUAAAAAGCCCACCA
8804
CUCUUuAAAAAGCCcACcAdTsdT
antis


 


1833-1852
8805
GUGGGCUUUUUAAAGAGGA
8806
GuGGGcuuuuuAAAGAGGAdTsdT
sense


 


1833-1852
8807
UCCUCUUUAAAAAGCCCAC
8808
UCCUCUUuAAAAAGCCcACdTsdT
antis


 


1837-1856
8809
GCUUUUUAAAGAGGAUUUU
8810
GcuuuuuAAAGAGGAuuuudTsdT
sense


 


1837-1856
8811
AAAAUCCUCUUUAAAAAGC
8812
AAAAUCCUCUUuAAAAAGCdTsdT
antis


 


1838-1857
8813
CUUUUUAAAGAGGAUUUUA
8814
cuuuuuAAAGAGGAuuuuAdTsdT
sense


 


1838-1857
8815
UAAAAUCCUCUUUAAAAAG
8816
uAAAAUCCUCUUuAAAAAGdTsdT
antis


 


1869-1888
8817
GGAGGGGAGAAAAGGAAGG
8818
GGAGGGGAGAAAAGGAAGGdTsdT
sense


 


1869-1888
8819
CCUUCCUUUUCUCCCCUCC
8820
CCUUCCUUUUCUCCCCUCCdTsdT
antis


 


1870-1889
8821
GAGGGGAGAAAAGGAAGGA
8822
GAGGGGAGAAAAGGAAGGAdTsdT
sense


 


1870-1889
8823
UCCUUCCUUUUCUCCCCUC
8824
UCCUUCCUUUUCUCCCCUCdTsdT
antis


 


1888-1907
8825
ACGGGGUUUGGGGGUGUGA
8826
AcGGGGuuuGGGGGuGuGAdTsdT
sense


 


1888-1907
8827
UCACACCCCCAAACCCCGU
8828
UcAcACCCCcAAACCCCGUdTsdT
antis


 


1923-1942
8829
UGGUCCCCUCCCCUCCCCC
8830
uGGuccccuccccucccccdTsdT
sense


 


1923-1942
8831
GGGGGAGGGGAGGGGACCA
8832
GGGGGAGGGGAGGGGACcAdTsdT
antis


 


1924-1943
8833
GGUCCCCUCCCCUCCCCCA
8834
GGuccccuccccucccccAdTsdT
sense


 


1924-1943
8835
UGGGGGAGGGGAGGGGACC
8836
UGGGGGAGGGGAGGGGACCdTsdT
antis


 


1931-1950
8837
UCCCCUCCCCCAGGCUACC
8838
uccccucccccAGGcuAccdTsdT
sense


 


1931-1950
8839
GGUAGCCUGGGGGAGGGGA
8840
GGuAGCCUGGGGGAGGGGAdTsdT
antis


 


1962-1981
8841
CCCCCCUCUCCCAGGUCCC
8842
ccccccucucccAGGucccdTsdT
sense


 


1962-1981
8843
GGGACCUGGGAGAGGGGGG
8844
GGGACCUGGGAGAGGGGGGdTsdT
antis


 


1963-1982
8845
CCCCCUCUCCCAGGUCCCU
8846
cccccucucccAGGucccudTsdT
sense


 


1963-1982
8847
AGGGACCUGGGAGAGGGGG
8848
AGGGACCUGGGAGAGGGGGdTsdT
antis


 


2132-2151
8849
CCAAGGCUUCCUCCCUCUC
8850
ccAAGGcuuccucccucucdTsdT
sense


 


2132-2151
8851
GAGAGGGAGGAAGCCUUGG
8852
GAGAGGGAGGAAGCCUUGGdTsdT
antis


 


2139-2158
8853
UUCCUCCCUCUCCCCAUCC
8854
uuccucccucuccccAuccdTsdT
sense


 


2139-2158
8855
GGAUGGGGAGAGGGAGGAA
8856
GGAUGGGGAGAGGGAGGAAdTsdT
antis


 


63-82
8857
UGGGCCGGAGCCGGAGCCC
8858
uGGGccGGAGccGGAGcccdTsdT
sense


 


63-82
8859
GGGCUCCGGCUCCGGCCCA
8860
GGGCUCCGGCUCCGGCCcAdTsdT
antis


 


65-84
8861
GGCCGGAGCCGGAGCCCGA
8862
GGccGGAGccGGAGcccGAdTsdT
sense


 


65-84
8863
UCGGGCUCCGGCUCCGGCC
8864
UCGGGCUCCGGCUCCGGCCdTsdT
antis


 


66-85
8865
GCCGGAGCCGGAGCCCGAA
8866
GccGGAGccGGAGcccGAAdTsdT
sense


 


66-85
8867
UUCGGGCUCCGGCUCCGGC
8868
UUCGGGCUCCGGCUCCGGCdTsdT
antis


 


115-134
8869
GGGAGGCGGCGGCAGAGGC
8870
GGGAGGcGGcGGcAGAGGcdTsdT
sense


 


115-134
8871
GCCUCUGCCGCCGCCUCCC
8872
GCCUCUGCCGCCGCCUCCCdTsdT
antis


 


118-137
8873
AGGCGGCGGCAGAGGCAGC
8874
AGGcGGcGGcAGAGGcAGcdTsdT
sense


 


118-137
8875
GCUGCCUCUGCCGCCGCCU
8876
GCUGCCUCUGCCGCCGCCUdTsdT
antis


 


119-138
8877
GGCGGCGGCAGAGGCAGCG
8878
GGcGGcGGcAGAGGcAGcGdTsdT
sense


 


119-138
8879
CGCUGCCUCUGCCGCCGCC
8880
CGCUGCCUCUGCCGCCGCCdTsdT
antis


 


128-147
8881
AGAGGCAGCGGCGGGGGCA
8882
AGAGGcAGcGGcGGGGGcAdTsdT
sense


 


128-147
8883
UGCCCCCGCCGCUGCCUCU
8884
UGCCCCCGCCGCUGCCUCUdTsdT
antis


 


129-148
8885
GAGGCAGCGGCGGGGGCAG
8886
GAGGcAGcGGcGGGGGcAGdTsdT
sense


 


129-148
8887
CUGCCCCCGCCGCUGCCUC
8888
CUGCCCCCGCCGCUGCCUCdTsdT
antis


 


265-284
8889
CAGGAGGCGGAGGCGGAGG
8890
cAGGAGGcGGAGGcGGAGGdTsdT
sense


 


265-284
8891
CCUCCGCCUCCGCCUCCUG
8892
CCUCCGCCUCCGCCUCCUGdTsdT
antis


 


266-285
8893
AGGAGGCGGAGGCGGAGGU
8894
AGGAGGcGGAGGcGGAGGudTsdT
sense


 


266-285
8895
ACCUCCGCCUCCGCCUCCU
8896
ACCUCCGCCUCCGCCUCCUdTsdT
antis


 


269-288
8897
AGGCGGAGGCGGAGGUGGU
8898
AGGcGGAGGcGGAGGuGGudTsdT
sense


 


269-288
8899
ACCACCUCCGCCUCCGCCU
8900
ACcACCUCCGCCUCCGCCUdTsdT
antis


 


275-294
8901
AGGCGGAGGUGGUGGCGGC
8902
AGGcGGAGGuGGuGGcGGcdTsdT
sense


 


275-294
8903
GCCGCCACCACCUCCGCCU
8904
GCCGCcACcACCUCCGCCUdTsdT
antis


 


278-297
8905
CGGAGGUGGUGGCGGCGGC
8906
cGGAGGuGGuGGcGGcGGcdTsdT
sense


 


278-297
8907
GCCGCCGCCACCACCUCCG
8908
GCCGCCGCcACcACCUCCGdTsdT
antis


 


279-298
8909
GGAGGUGGUGGCGGCGGCC
8910
GGAGGuGGuGGcGGcGGccdTsdT
sense


 


279-298
8911
GGCCGCCGCCACCACCUCC
8912
GGCCGCCGCcACcACCUCCdTsdT
antis


 


314-333
8913
UGGCCCAGGAGGCACUGGC
8914
uGGcccAGGAGGcAcuGGcdTsdT
sense


 


314-333
8915
GCCAGUGCCUCCUGGGCCA
8916
GCcAGUGCCUCCUGGGCcAdTsdT
antis


 


399-418
8917
AGCGGCAGCGGCGGAGGAG
8918
AGcGGcAGcGGcGGAGGAGdTsdT
sense


 


399-418
8919
CUCCUCCGCCGCUGCCGCU
8920
CUCCUCCGCCGCUGCCGCUdTsdT
antis


 


411-430
8921
GGAGGAGGCAGCGGUGGCC
8922
GGAGGAGGcAGcGGuGGccdTsdT
sense


 


411-430
8923
GGCCACCGCUGCCUCCUCC
8924
GGCcACCGCUGCCUCCUCCdTsdT
antis


 


412-431
8925
GAGGAGGCAGCGGUGGCCC
8926
GAGGAGGcAGcGGuGGcccdTsdT
sense


 


412-431
8927
GGGCCACCGCUGCCUCCUC
8928
GGGCcACCGCUGCCUCCUCdTsdT
antis


 


413-432
8929
AGGAGGCAGCGGUGGCCCC
8930
AGGAGGcAGcGGuGGccccdTsdT
sense


 


413-432
8931
GGGGCCACCGCUGCCUCCU
8932
GGGGCcACCGCUGCCUCCUdTsdT
antis


 


414-433
8933
GGAGGCAGCGGUGGCCCCG
8934
GGAGGcAGcGGuGGccccGdTsdT
sense


 


414-433
8935
CGGGGCCACCGCUGCCUCC
8936
CGGGGCcACCGCUGCCUCCdTsdT
antis


 


636-655
8937
AAGGUUCUUCAGGACAAAA
8938
AAGGuucuucAGGAcAAAAdTsdT
sense


 


636-655
8939
UUUUGUCCUGAAGAACCUU
8940
UUUUGUCCUGAAGAACCUUdTsdT
antis


 


731-750
8941
CUCCAGUGGGGAGAAGAAG
8942
cuccAGuGGGGAGAAGAAGdTsdT
sense


 


731-750
8943
CUUCUUCUCCCCACUGGAG
8944
CUUCUUCUCCCcACUGGAGdTsdT
antis


 


733-752
8945
CCAGUGGGGAGAAGAAGGA
8946
ccAGuGGGGAGAAGAAGGAdTsdT
sense


 


733-752
8947
UCCUUCUUCUCCCCACUGG
8948
UCCUUCUUCUCCCcACUGGdTsdT
antis


 


963-982
8949
GUCCUCAAGCUCUGCGAUU
8950
GuccucAAGcucuGcGAuudTsdT
sense


 


963-982
8951
AAUCGCAGAGCUUGAGGAC
8952
AAUCGcAGAGCUUGAGGACdTsdT
antis


 


1535-1554
8953
CCCAGCAGGCCCUGCUUCU
8954
cccAGcAGGcccuGcuucudTsdT
sense


 


1535-1554
8955
AGAAGCAGGGCCUGCUGGG
8956
AGAAGcAGGGCCUGCUGGGdTsdT
antis


 


1536-1555
8957
CCAGCAGGCCCUGCUUCUC
8958
ccAGcAGGcccuGcuucucdTsdT
sense


 


1536-1555
8959
GAGAAGCAGGGCCUGCUGG
8960
GAGAAGcAGGGCCUGCUGGdTsdT
antis


 


1537-1556
8961
CAGCAGGCCCUGCUUCUCC
8962
cAGcAGGcccuGcuucuccdTsdT
sense


 


1537-1556
8963
GGAGAAGCAGGGCCUGCUG
8964
GGAGAAGcAGGGCCUGCUGdTsdT
antis


 


1887-1906
8965
GACGGGGUUUGGGGGUGUG
8966
GAcGGGGuuuGGGGGuGuGdTsdT
sense


 


1887-1906
8967
CACACCCCCAAACCCCGUC
8968
cAcACCCCcAAACCCCGUCdTsdT
antis


 


1925-1944
8969
GUCCCCUCCCCUCCCCCAG
8970
GuccccuccccucccccAGdTsdT
sense


 


1925-1944
8971
CUGGGGGAGGGGAGGGGAC
8972
CUGGGGGAGGGGAGGGGACdTsdT
antis


 


1926-1945
8973
UCCCCUCCCCUCCCCCAGG
8974
uccccuccccucccccAGGdTsdT
sense


 


1926-1945
8975
CCUGGGGGAGGGGAGGGGA
8976
CCUGGGGGAGGGGAGGGGAdTsdT
antis


 


2055-2074
8977
AUUUUUUCUUAAAGAAAAC
8978
AuuuuuucuuAAAGAAAAcdTsdT
sense


 


2055-2074
8979
GUUUUCUUUAAGAAAAAAU
8980
GUUUUCUUuAAGAAAAAAUdTsdT
antis


 


2143-2162
8981
UCCCUCUCCCCAUCCUGGA
8982
ucccucuccccAuccuGGAdTsdT
sense


 


2143-2162
8983
UCCAGGAUGGGGAGAGGGA
8984
UCcAGGAUGGGGAGAGGGAdTsdT
antis
















TABLE 2







Sequences of duplexes targeting Mouse GSK3-beta


Sequences of duplexes targeting mouse GSK3-beta. Target


sequence location identifies target sequence in mouse GSK3-beta


mRNA NM_019827.6. Sense strand is identical to target


sequence. Antisense strand is complementary to target sequence.












Target
SEQ

SEQ




sequence
ID
Unmodified sequence
ID
Modified sequence


location
NO:
5′ to 3′
NO:
5′ to 3′
Strand















1842-1861
8985
ACUGUAACAUAGUCCGACU
10985
AcuGuAAcAuAGuccGAcudTsdT
sense


 


1842-1861
8986
AGUCGGACUAUGUUACAGU
10986
AGUCGGACuAUGUuAcAGUdTsdT
antis


 


1843-1862
8987
CUGUAACAUAGUCCGACUG
10987
cuGuAAcAuAGuccGAcuGdTsdT
sense


 


1843-1862
8988
CAGUCGGACUAUGUUACAG
10988
cAGUCGGACuAUGUuAcAGdTsdT
antis


 


1952-1971
8989
GCCAGACACUAUAGUCGAG
10989
GccAGAcAcuAuAGucGAGdTsdT
sense


 


1952-1971
8990
CUCGACUAUAGUGUCUGGC
10990
CUCGACuAuAGUGUCUGGCdTsdT
antis


 


1847-1866
8991
AACAUAGUCCGACUGCGGU
10991
AAcAuAGuccGAcuGcGGudTsdT
sense


 


1847-1866
8992
ACCGCAGUCGGACUAUGUU
10992
ACCGcAGUCGGACuAUGUUdTsdT
antis


 


1838-1857
8993
GACCACUGUAACAUAGUCC
10993
GAccAcuGuAAcAuAGuccdTsdT
sense


 


1838-1857
8994
GGACUAUGUUACAGUGGUC
10994
GGACuAUGUuAcAGUGGUCdTsdT
antis


 


1846-1865
8995
UAACAUAGUCCGACUGCGG
10995
uAAcAuAGuccGAcuGcGGdTsdT
sense


 


1846-1865
8996
CCGCAGUCGGACUAUGUUA
10996
CCGcAGUCGGACuAUGUuAdTsdT
antis


 


1849-1868
8997
CAUAGUCCGACUGCGGUAU
10997
cAuAGuccGAcuGcGGuAudTsdT
sense


 


1849-1868
8998
AUACCGCAGUCGGACUAUG
10998
AuACCGcAGUCGGACuAUGdTsdT
antis


 


1955-1974
8999
AGACACUAUAGUCGAGCCA
10999
AGAcAcuAuAGucGAGccAdTsdT
sense


 


1955-1974
9000
UGGCUCGACUAUAGUGUCU
11000
UGGCUCGACuAuAGUGUCUdTsdT
antis


 


1957-1976
9001
ACACUAUAGUCGAGCCAAG
11001
AcAcuAuAGucGAGccAAGdTsdT
sense


 


1957-1976
9002
CUUGGCUCGACUAUAGUGU
11002
CUUGGCUCGACuAuAGUGUdTsdT
antis


 


2169-2188
9003
CAUAUAUCUGUUCUCGGUA
11003
cAuAuAucuGuucucGGuAdTsdT
sense


 


2169-2188
9004
UACCGAGAACAGAUAUAUG
11004
uACCGAGAAcAGAuAuAUGdTsdT
antis


 


1788-1807
9005
UACAGGACAAGCGAUUUAA
11005
uAcAGGAcAAGcGAuuuAAdTsdT
sense


 


1788-1807
9006
UUAAAUCGCUUGUCCUGUA
11006
UuAAAUCGCUUGUCCUGuAdTsdT
antis


 


1862-1881
9007
CGGUAUUUCUUCUACUCGA
11007
cGGuAuuucuucuAcucGAdTsdT
sense


 


1862-1881
9008
UCGAGUAGAAGAAAUACCG
11008
UCGAGuAGAAGAAAuACCGdTsdT
antis


 


2021-2040
9009
UUCAGAAGUCUAGCCUAUA
11009
uucAGAAGucuAGccuAuAdTsdT
sense


 


2021-2040
9010
UAUAGGCUAGACUUCUGAA
11010
uAuAGGCuAGACUUCUGAAdTsdT
antis


 


1863-1882
9011
GGUAUUUCUUCUACUCGAG
11011
GGuAuuucuucuAcucGAGdTsdT
sense


 


1863-1882
9012
CUCGAGUAGAAGAAAUACC
11012
CUCGAGuAGAAGAAAuACCdTsdT
antis


 


2496-2515
9013
CACCUACCGCCCGGCUAAC
11013
cAccuAccGcccGGcuAAcdTsdT
sense


 


2496-2515
9014
GUUAGCCGGGCGGUAGGUG
11014
GUuAGCCGGGCGGuAGGUGdTsdT
antis


 


1796-1815
9015
AAGCGAUUUAAGAACCGAG
11015
AAGcGAuuuAAGAAccGAGdTsdT
sense


 


1796-1815
9016
CUCGGUUCUUAAAUCGCUU
11016
CUCGGUUCUuAAAUCGCUUdTsdT
antis


 


1844-1863
9017
UGUAACAUAGUCCGACUGC
11017
uGuAAcAuAGuccGAcuGcdTsdT
sense


 


1844-1863
9018
GCAGUCGGACUAUGUUACA
11018
GcAGUCGGACuAUGUuAcAdTsdT
antis


 


2221-2240
9019
UGAUUACACGUCCAGUAUA
11019
uGAuuAcAcGuccAGuAuAdTsdT
sense


 


2221-2240
9020
UAUACUGGACGUGUAAUCA
11020
uAuACUGGACGUGuAAUcAdTsdT
antis


 


2228-2247
9021
ACGUCCAGUAUAGAUGUAU
11021
AcGuccAGuAuAGAuGuAudTsdT
sense


 


2228-2247
9022
AUACAUCUAUACUGGACGU
11022
AuAcAUCuAuACUGGACGUdTsdT
antis


 


1697-1716
9023
GACACGAAAGUGAUUGGAA
11023
GAcAcGAAAGuGAuuGGAAdTsdT
sense


 


1697-1716
9024
UUCCAAUCACUUUCGUGUC
11024
UUCcAAUcACUUUCGUGUCdTsdT
antis


 


1845-1864
9025
GUAACAUAGUCCGACUGCG
11025
GuAAcAuAGuccGAcuGcGdTsdT
sense


 


1845-1864
9026
CGCAGUCGGACUAUGUUAC
11026
CGcAGUCGGACuAUGUuACdTsdT
antis


 


1851-1870
9027
UAGUCCGACUGCGGUAUUU
11027
uAGuccGAcuGcGGuAuuudTsdT
sense


 


1851-1870
9028
AAAUACCGCAGUCGGACUA
11028
AAAuACCGcAGUCGGACuAdTsdT
antis


 


1871-1890
9029
UUCUACUCGAGUGGUGAGA
11029
uucuAcucGAGuGGuGAGAdTsdT
sense


 


1871-1890
9030
UCUCACCACUCGAGUAGAA
11030
UCUcACcACUCGAGuAGAAdTsdT
antis


 


2022-2041
9031
UCAGAAGUCUAGCCUAUAU
11031
ucAGAAGucuAGccuAuAudTsdT
sense


 


2022-2041
9032
AUAUAGGCUAGACUUCUGA
11032
AuAuAGGCuAGACUUCUGAdTsdT
antis


 


2024-2043
9033
AGAAGUCUAGCCUAUAUCC
11033
AGAAGucuAGccuAuAuccdTsdT
sense


 


2024-2043
9034
GGAUAUAGGCUAGACUUCU
11034
GGAuAuAGGCuAGACUUCUdTsdT
antis


 


2220-2239
9035
CUGAUUACACGUCCAGUAU
11035
cuGAuuAcAcGuccAGuAudTsdT
sense


 


2220-2239
9036
AUACUGGACGUGUAAUCAG
11036
AuACUGGACGUGuAAUcAGdTsdT
antis


 


1789-1808
9037
ACAGGACAAGCGAUUUAAG
11037
AcAGGAcAAGcGAuuuAAGdTsdT
sense


 


1789-1808
9038
CUUAAAUCGCUUGUCCUGU
11038
CUuAAAUCGCUUGUCCUGUdTsdT
antis


 


1922-1941
9039
GACUAUGUUCCGGAGACAG
11039
GAcuAuGuuccGGAGAcAGdTsdT
sense


 


1922-1941
9040
CUGUCUCCGGAACAUAGUC
11040
CUGUCUCCGGAAcAuAGUCdTsdT
antis


 


2020-2039
9041
GUUCAGAAGUCUAGCCUAU
11041
GuucAGAAGucuAGccuAudTsdT
sense


 


2020-2039
9042
AUAGGCUAGACUUCUGAAC
11042
AuAGGCuAGACUUCUGAACdTsdT
antis


 


2492-2511
9043
UACACACCUACCGCCCGGC
11043
uAcAcAccuAccGcccGGcdTsdT
sense


 


2492-2511
9044
GCCGGGCGGUAGGUGUGUA
11044
GCCGGGCGGuAGGUGUGuAdTsdT
antis


 


1678-1697
9045
ACAGGAAGUCAGUUAUACA
11045
AcAGGAAGucAGuuAuAcAdTsdT
sense


 


1678-1697
9046
UGUAUAACUGACUUCCUGU
11046
UGuAuAACUGACUUCCUGUdTsdT
antis


 


1840-1859
9047
CCACUGUAACAUAGUCCGA
11047
ccAcuGuAAcAuAGuccGAdTsdT
sense


 


1840-1859
9048
UCGGACUAUGUUACAGUGG
11048
UCGGACuAUGUuAcAGUGGdTsdT
antis


 


2487-2506
9049
UGGAGUACACACCUACCGC
11049
uGGAGuAcAcAccuAccGcdTsdT
sense


 


2487-2506
9050
GCGGUAGGUGUGUACUCCA
11050
GCGGuAGGUGUGuACUCcAdTsdT
antis


 


1924-1943
9051
CUAUGUUCCGGAGACAGUG
11051
cuAuGuuccGGAGAcAGuGdTsdT
sense


 


1924-1943
9052
CACUGUCUCCGGAACAUAG
11052
cACUGUCUCCGGAAcAuAGdTsdT
antis


 


2176-2195
9053
CUGUUCUCGGUACUACAGG
11053
cuGuucucGGuAcuAcAGGdTsdT
sense


 


2176-2195
9054
CCUGUAGUACCGAGAACAG
11054
CCUGuAGuACCGAGAAcAGdTsdT
antis


 


2177-2196
9055
UGUUCUCGGUACUACAGGG
11055
uGuucucGGuAcuAcAGGGdTsdT
sense


 


2177-2196
9056
CCCUGUAGUACCGAGAACA
11056
CCCUGuAGuACCGAGAAcAdTsdT
antis


 


2502-2521
9057
CCGCCCGGCUAACACCACU
11057
ccGcccGGcuAAcAccAcudTsdT
sense


 


2502-2521
9058
AGUGGUGUUAGCCGGGCGG
11058
AGUGGUGUuAGCCGGGCGGdTsdT
antis


 


2499-2518
9059
CUACCGCCCGGCUAACACC
11059
cuAccGcccGGcuAAcAccdTsdT
sense


 


2499-2518
9060
GGUGUUAGCCGGGCGGUAG
11060
GGUGUuAGCCGGGCGGuAGdTsdT
antis


 


2223-2242
9061
AUUACACGUCCAGUAUAGA
11061
AuuAcAcGuccAGuAuAGAdTsdT
sense


 


2223-2242
9062
UCUAUACUGGACGUGUAAU
11062
UCuAuACUGGACGUGuAAUdTsdT
antis


 


1873-1892
9063
CUACUCGAGUGGUGAGAAG
11063
cuAcucGAGuGGuGAGAAGdTsdT
sense


 


1873-1892
9064
CUUCUCACCACUCGAGUAG
11064
CUUCUcACcACUCGAGuAGdTsdT
antis


 


1918-1937
9065
GCUGGACUAUGUUCCGGAG
11065
GcuGGAcuAuGuuccGGAGdTsdT
sense


 


1918-1937
9066
CUCCGGAACAUAGUCCAGC
11066
CUCCGGAAcAuAGUCcAGCdTsdT
antis


 


1919-1938
9067
CUGGACUAUGUUCCGGAGA
11067
cuGGAcuAuGuuccGGAGAdTsdT
sense


 


1919-1938
9068
UCUCCGGAACAUAGUCCAG
11068
UCUCCGGAAcAuAGUCcAGdTsdT
antis


 


1950-1969
9069
UCGCCAGACACUAUAGUCG
11069
ucGccAGAcAcuAuAGucGdTsdT
sense


 


1950-1969
9070
CGACUAUAGUGUCUGGCGA
11070
CGACuAuAGUGUCUGGCGAdTsdT
antis


 


1958-1977
9071
CACUAUAGUCGAGCCAAGC
11071
cAcuAuAGucGAGccAAGcdTsdT
sense


 


1958-1977
9072
GCUUGGCUCGACUAUAGUG
11072
GCUUGGCUCGACuAuAGUGdTsdT
antis


 


2222-2241
9073
GAUUACACGUCCAGUAUAG
11073
GAuuAcAcGuccAGuAuAGdTsdT
sense


 


2222-2241
9074
CUAUACUGGACGUGUAAUC
11074
CuAuACUGGACGUGuAAUCdTsdT
antis


 


2224-2243
9075
UUACACGUCCAGUAUAGAU
11075
uuAcAcGuccAGuAuAGAudTsdT
sense


 


2224-2243
9076
AUCUAUACUGGACGUGUAA
11076
AUCuAuACUGGACGUGuAAdTsdT
antis


 


2440-2459
9077
CCGGCCCCGAACUCCACCA
11077
ccGGccccGAAcuccAccAdTsdT
sense


 


2440-2459
9078
UGGUGGAGUUCGGGGCCGG
11078
UGGUGGAGUUCGGGGCCGGdTsdT
antis


 


2493-2512
9079
ACACACCUACCGCCCGGCU
11079
AcAcAccuAccGcccGGcudTsdT
sense


 


2493-2512
9080
AGCCGGGCGGUAGGUGUGU
11080
AGCCGGGCGGuAGGUGUGUdTsdT
antis


 


2494-2513
9081
CACACCUACCGCCCGGCUA
11081
cAcAccuAccGcccGGcuAdTsdT
sense


 


2494-2513
9082
UAGCCGGGCGGUAGGUGUG
11082
uAGCCGGGCGGuAGGUGUGdTsdT
antis


 


2497-2516
9083
ACCUACCGCCCGGCUAACA
11083
AccuAccGcccGGcuAAcAdTsdT
sense


 


2497-2516
9084
UGUUAGCCGGGCGGUAGGU
11084
UGUuAGCCGGGCGGuAGGUdTsdT
antis


 


2498-2517
9085
CCUACCGCCCGGCUAACAC
11085
ccuAccGcccGGcuAAcAcdTsdT
sense


 


2498-2517
9086
GUGUUAGCCGGGCGGUAGG
11086
GUGUuAGCCGGGCGGuAGGdTsdT
antis


 


1525-1544
9087
CAUGUCGGGGCGACCGAGA
11087
cAuGucGGGGcGAccGAGAdTsdT
sense


 


1525-1544
9088
UCUCGGUCGCCCCGACAUG
11088
UCUCGGUCGCCCCGAcAUGdTsdT
antis


 


1528-1547
9089
GUCGGGGCGACCGAGAACC
11089
GucGGGGcGAccGAGAAccdTsdT
sense


 


1528-1547
9090
GGUUCUCGGUCGCCCCGAC
11090
GGUUCUCGGUCGCCCCGACdTsdT
antis


 


1533-1552
9091
GGCGACCGAGAACCACCUC
11091
GGcGAccGAGAAccAccucdTsdT
sense


 


1533-1552
9092
GAGGUGGUUCUCGGUCGCC
11092
GAGGUGGUUCUCGGUCGCCdTsdT
antis


 


1793-1812
9093
GACAAGCGAUUUAAGAACC
11093
GAcAAGcGAuuuAAGAAccdTsdT
sense


 


1793-1812
9094
GGUUCUUAAAUCGCUUGUC
11094
GGUUCUuAAAUCGCUUGUCdTsdT
antis


 


1797-1816
9095
AGCGAUUUAAGAACCGAGA
11095
AGcGAuuuAAGAAccGAGAdTsdT
sense


 


1797-1816
9096
UCUCGGUUCUUAAAUCGCU
11096
UCUCGGUUCUuAAAUCGCUdTsdT
antis


 


1798-1817
9097
GCGAUUUAAGAACCGAGAG
11097
GcGAuuuAAGAAccGAGAGdTsdT
sense


 


1798-1817
9098
CUCUCGGUUCUUAAAUCGC
11098
CUCUCGGUUCUuAAAUCGCdTsdT
antis


 


1799-1818
9099
CGAUUUAAGAACCGAGAGC
11099
cGAuuuAAGAAccGAGAGcdTsdT
sense


 


1799-1818
9100
GCUCUCGGUUCUUAAAUCG
11100
GCUCUCGGUUCUuAAAUCGdTsdT
antis


 


1832-1851
9101
AAGCUAGACCACUGUAACA
11101
AAGcuAGAccAcuGuAAcAdTsdT
sense


 


1832-1851
9102
UGUUACAGUGGUCUAGCUU
11102
UGUuAcAGUGGUCuAGCUUdTsdT
antis


 


1836-1855
9103
UAGACCACUGUAACAUAGU
11103
uAGAccAcuGuAAcAuAGudTsdT
sense


 


1836-1855
9104
ACUAUGUUACAGUGGUCUA
11104
ACuAUGUuAcAGUGGUCuAdTsdT
antis


 


1850-1869
9105
AUAGUCCGACUGCGGUAUU
11105
AuAGuccGAcuGcGGuAuudTsdT
sense


 


1850-1869
9106
AAUACCGCAGUCGGACUAU
11106
AAuACCGcAGUCGGACuAUdTsdT
antis


 


1852-1871
9107
AGUCCGACUGCGGUAUUUC
11107
AGuccGAcuGcGGuAuuucdTsdT
sense


 


1852-1871
9108
GAAAUACCGCAGUCGGACU
11108
GAAAuACCGcAGUCGGACUdTsdT
antis


 


1853-1872
9109
GUCCGACUGCGGUAUUUCU
11109
GuccGAcuGcGGuAuuucudTsdT
sense


 


1853-1872
9110
AGAAAUACCGCAGUCGGAC
11110
AGAAAuACCGcAGUCGGACdTsdT
antis


 


1855-1874
9111
CCGACUGCGGUAUUUCUUC
11111
ccGAcuGcGGuAuuucuucdTsdT
sense


 


1855-1874
9112
GAAGAAAUACCGCAGUCGG
11112
GAAGAAAuACCGcAGUCGGdTsdT
antis


 


1870-1889
9113
CUUCUACUCGAGUGGUGAG
11113
cuucuAcucGAGuGGuGAGdTsdT
sense


 


1870-1889
9114
CUCACCACUCGAGUAGAAG
11114
CUcACcACUCGAGuAGAAGdTsdT
antis


 


1895-1914
9115
GAUGAGGUCUACCUUAACC
11115
GAuGAGGucuAccuuAAccdTsdT
sense


 


1895-1914
9116
GGUUAAGGUAGACCUCAUC
11116
GGUuAAGGuAGACCUcAUCdTsdT
antis


 


1916-1935
9117
GUGCUGGACUAUGUUCCGG
11117
GuGcuGGAcuAuGuuccGGdTsdT
sense


 


1916-1935
9118
CCGGAACAUAGUCCAGCAC
11118
CCGGAAcAuAGUCcAGcACdTsdT
antis


 


1927-1946
9119
UGUUCCGGAGACAGUGUAC
11119
uGuuccGGAGAcAGuGuAcdTsdT
sense


 


1927-1946
9120
GUACACUGUCUCCGGAACA
11120
GuAcACUGUCUCCGGAAcAdTsdT
antis


 


1953-1972
9121
CCAGACACUAUAGUCGAGC
11121
ccAGAcAcuAuAGucGAGcdTsdT
sense


 


1953-1972
9122
GCUCGACUAUAGUGUCUGG
11122
GCUCGACuAuAGUGUCUGGdTsdT
antis


 


1959-1978
9123
ACUAUAGUCGAGCCAAGCA
11123
AcuAuAGucGAGccAAGcAdTsdT
sense


 


1959-1978
9124
UGCUUGGCUCGACUAUAGU
11124
UGCUUGGCUCGACuAuAGUdTsdT
antis


 


1960-1979
9125
CUAUAGUCGAGCCAAGCAG
11125
cuAuAGucGAGccAAGcAGdTsdT
sense


 


1960-1979
9126
CUGCUUGGCUCGACUAUAG
11126
CUGCUUGGCUCGACuAuAGdTsdT
antis


 


2023-2042
9127
CAGAAGUCUAGCCUAUAUC
11127
cAGAAGucuAGccuAuAucdTsdT
sense


 


2023-2042
9128
GAUAUAGGCUAGACUUCUG
11128
GAuAuAGGCuAGACUUCUGdTsdT
antis


 


2089-2108
9129
GUUGGAUCCUGAUACAGCU
11129
GuuGGAuccuGAuAcAGcudTsdT
sense


 


2089-2108
9130
AGCUGUAUCAGGAUCCAAC
11130
AGCUGuAUcAGGAUCcAACdTsdT
antis


 


2179-2198
9131
UUCUCGGUACUACAGGGCA
11131
uucucGGuAcuAcAGGGcAdTsdT
sense


 


2179-2198
9132
UGCCCUGUAGUACCGAGAA
11132
UGCCCUGuAGuACCGAGAAdTsdT
antis


 


2188-2207
9133
CUACAGGGCACCAGAGUUG
11133
cuAcAGGGcAccAGAGuuGdTsdT
sense


 


2188-2207
9134
CAACUCUGGUGCCCUGUAG
11134
cAACUCUGGUGCCCUGuAGdTsdT
antis


 


2218-2237
9135
CACUGAUUACACGUCCAGU
11135
cAcuGAuuAcAcGuccAGudTsdT
sense


 


2218-2237
9136
ACUGGACGUGUAAUCAGUG
11136
ACUGGACGUGuAAUcAGUGdTsdT
antis


 


2219-2238
9137
ACUGAUUACACGUCCAGUA
11137
AcuGAuuAcAcGuccAGuAdTsdT
sense


 


2219-2238
9138
UACUGGACGUGUAAUCAGU
11138
uACUGGACGUGuAAUcAGUdTsdT
antis


 


2226-2245
9139
ACACGUCCAGUAUAGAUGU
11139
AcAcGuccAGuAuAGAuGudTsdT
sense


 


2226-2245
9140
ACAUCUAUACUGGACGUGU
11140
AcAUCuAuACUGGACGUGUdTsdT
antis


 


2227-2246
9141
CACGUCCAGUAUAGAUGUA
11141
cAcGuccAGuAuAGAuGuAdTsdT
sense


 


2227-2246
9142
UACAUCUAUACUGGACGUG
11142
uAcAUCuAuACUGGACGUGdTsdT
antis


 


2276-2295
9143
UUGCUAGGACAACCAAUAU
11143
uuGcuAGGAcAAccAAuAudTsdT
sense


 


2276-2295
9144
AUAUUGGUUGUCCUAGCAA
11144
AuAUUGGUUGUCCuAGcAAdTsdT
antis


 


2277-2296
9145
UGCUAGGACAACCAAUAUU
11145
uGcuAGGAcAAccAAuAuudTsdT
sense


 


2277-2296
9146
AAUAUUGGUUGUCCUAGCA
11146
AAuAUUGGUUGUCCuAGcAdTsdT
antis


 


2279-2298
9147
CUAGGACAACCAAUAUUUC
11147
cuAGGAcAAccAAuAuuucdTsdT
sense


 


2279-2298
9148
GAAAUAUUGGUUGUCCUAG
11148
GAAAuAUUGGUUGUCCuAGdTsdT
antis


 


2306-2325
9149
AGUGGUGUGGAUCAGUUGG
11149
AGuGGuGuGGAucAGuuGGdTsdT
sense


 


2306-2325
9150
CCAACUGAUCCACACCACU
11150
CcAACUGAUCcAcACcACUdTsdT
antis


 


2488-2507
9151
GGAGUACACACCUACCGCC
11151
GGAGuAcAcAccuAccGccdTsdT
sense


 


2488-2507
9152
GGCGGUAGGUGUGUACUCC
11152
GGCGGuAGGUGUGuACUCCdTsdT
antis


 


2491-2510
9153
GUACACACCUACCGCCCGG
11153
GuAcAcAccuAccGcccGGdTsdT
sense


 


2491-2510
9154
CCGGGCGGUAGGUGUGUAC
11154
CCGGGCGGuAGGUGUGuACdTsdT
antis


 


2501-2520
9155
ACCGCCCGGCUAACACCAC
11155
AccGcccGGcuAAcAccAcdTsdT
sense


 


2501-2520
9156
GUGGUGUUAGCCGGGCGGU
11156
GUGGUGUuAGCCGGGCGGUdTsdT
antis


 


2506-2525
9157
CCGGCUAACACCACUGGAA
11157
ccGGcuAAcAccAcuGGAAdTsdT
sense


 


2506-2525
9158
UUCCAGUGGUGUUAGCCGG
11158
UUCcAGUGGUGUuAGCCGGdTsdT
antis


 


1695-1714
9159
CAGACACGAAAGUGAUUGG
11159
cAGAcAcGAAAGuGAuuGGdTsdT
sense


 


1695-1714
9160
CCAAUCACUUUCGUGUCUG
11160
CcAAUcACUUUCGUGUCUGdTsdT
antis


 


1720-1739
9161
AUCAUUUGGUGUGGUAUAU
11161
AucAuuuGGuGuGGuAuAudTsdT
sense


 


1720-1739
9162
AUAUACCACACCAAAUGAU
11162
AuAuACcAcACcAAAUGAUdTsdT
antis


 


1722-1741
9163
CAUUUGGUGUGGUAUAUCA
11163
cAuuuGGuGuGGuAuAucAdTsdT
sense


 


1722-1741
9164
UGAUAUACCACACCAAAUG
11164
UGAuAuACcAcACcAAAUGdTsdT
antis


 


1833-1852
9165
AGCUAGACCACUGUAACAU
11165
AGcuAGAccAcuGuAAcAudTsdT
sense


 


1833-1852
9166
AUGUUACAGUGGUCUAGCU
11166
AUGUuAcAGUGGUCuAGCUdTsdT
antis


 


1848-1867
9167
ACAUAGUCCGACUGCGGUA
11167
AcAuAGuccGAcuGcGGuAdTsdT
sense


 


1848-1867
9168
UACCGCAGUCGGACUAUGU
11168
uACCGcAGUCGGACuAUGUdTsdT
antis


 


1872-1891
9169
UCUACUCGAGUGGUGAGAA
11169
ucuAcucGAGuGGuGAGAAdTsdT
sense


 


1872-1891
9170
UUCUCACCACUCGAGUAGA
11170
UUCUcACcACUCGAGuAGAdTsdT
antis


 


1998-2017
9171
UCAAGUUGUAUAUGUAUCA
11171
ucAAGuuGuAuAuGuAucAdTsdT
sense


 


1998-2017
9172
UGAUACAUAUACAACUUGA
11172
UGAuAcAuAuAcAACUUGAdTsdT
antis


 


2011-2030
9173
GUAUCAGCUGUUCAGAAGU
11173
GuAucAGcuGuucAGAAGudTsdT
sense


 


2011-2030
9174
ACUUCUGAACAGCUGAUAC
11174
ACUUCUGAAcAGCUGAuACdTsdT
antis


 


2054-2073
9175
AUCUGCCAUCGAGACAUUA
11175
AucuGccAucGAGAcAuuAdTsdT
sense


 


2054-2073
9176
UAAUGUCUCGAUGGCAGAU
11176
uAAUGUCUCGAUGGcAGAUdTsdT
antis


 


2153-2172
9177
GGAGAGCCCAAUGUUUCAU
11177
GGAGAGcccAAuGuuucAudTsdT
sense


 


2153-2172
9178
AUGAAACAUUGGGCUCUCC
11178
AUGAAAcAUUGGGCUCUCCdTsdT
antis


 


2168-2187
9179
UCAUAUAUCUGUUCUCGGU
11179
ucAuAuAucuGuucucGGudTsdT
sense


 


2168-2187
9180
ACCGAGAACAGAUAUAUGA
11180
ACCGAGAAcAGAuAuAUGAdTsdT
antis


 


2181-2200
9181
CUCGGUACUACAGGGCACC
11181
cucGGuAcuAcAGGGcAccdTsdT
sense


 


2181-2200
9182
GGUGCCCUGUAGUACCGAG
11182
GGUGCCCUGuAGuACCGAGdTsdT
antis


 


2305-2324
9183
CAGUGGUGUGGAUCAGUUG
11183
cAGuGGuGuGGAucAGuuGdTsdT
sense


 


2305-2324
9184
CAACUGAUCCACACCACUG
11184
cAACUGAUCcAcACcACUGdTsdT
antis


 


2354-2373
9185
ACAAGGGAGCAAAUUAGAG
11185
AcAAGGGAGcAAAuuAGAGdTsdT
sense


 


2354-2373
9186
CUCUAAUUUGCUCCCUUGU
11186
CUCuAAUUUGCUCCCUUGUdTsdT
antis


 


2427-2446
9187
GGACAAAGGUCUUCCGGCC
11187
GGAcAAAGGucuuccGGccdTsdT
sense


 


2427-2446
9188
GGCCGGAAGACCUUUGUCC
11188
GGCCGGAAGACCUUUGUCCdTsdT
antis


 


1529-1548
9189
UCGGGGCGACCGAGAACCA
11189
ucGGGGcGAccGAGAAccAdTsdT
sense


 


1529-1548
9190
UGGUUCUCGGUCGCCCCGA
11190
UGGUUCUCGGUCGCCCCGAdTsdT
antis


 


1532-1551
9191
GGGCGACCGAGAACCACCU
11191
GGGcGAccGAGAAccAccudTsdT
sense


 


1532-1551
9192
AGGUGGUUCUCGGUCGCCC
11192
AGGUGGUUCUCGGUCGCCCdTsdT
antis


 


1541-1560
9193
AGAACCACCUCCUUUGCGG
11193
AGAAccAccuccuuuGcGGdTsdT
sense


 


1541-1560
9194
CCGCAAAGGAGGUGGUUCU
11194
CCGcAAAGGAGGUGGUUCUdTsdT
antis


 


1591-1610
9195
UUUUGGUAGCAUGAAAGUU
11195
uuuuGGuAGcAuGAAAGuudTsdT
sense


 


1591-1610
9196
AACUUUCAUGCUACCAAAA
11196
AACUUUcAUGCuACcAAAAdTsdT
antis


 


1677-1696
9197
CACAGGAAGUCAGUUAUAC
11197
cAcAGGAAGucAGuuAuAcdTsdT
sense


 


1677-1696
9198
GUAUAACUGACUUCCUGUG
11198
GuAuAACUGACUUCCUGUGdTsdT
antis


 


1679-1698
9199
CAGGAAGUCAGUUAUACAG
11199
cAGGAAGucAGuuAuAcAGdTsdT
sense


 


1679-1698
9200
CUGUAUAACUGACUUCCUG
11200
CUGuAuAACUGACUUCCUGdTsdT
antis


 


1680-1699
9201
AGGAAGUCAGUUAUACAGA
11201
AGGAAGucAGuuAuAcAGAdTsdT
sense


 


1680-1699
9202
UCUGUAUAACUGACUUCCU
11202
UCUGuAuAACUGACUUCCUdTsdT
antis


 


1681-1700
9203
GGAAGUCAGUUAUACAGAC
11203
GGAAGucAGuuAuAcAGAcdTsdT
sense


 


1681-1700
9204
GUCUGUAUAACUGACUUCC
11204
GUCUGuAuAACUGACUUCCdTsdT
antis


 


1705-1724
9205
AGUGAUUGGAAAUGGAUCA
11205
AGuGAuuGGAAAuGGAucAdTsdT
sense


 


1705-1724
9206
UGAUCCAUUUCCAAUCACU
11206
UGAUCcAUUUCcAAUcACUdTsdT
antis


 


1706-1725
9207
GUGAUUGGAAAUGGAUCAU
11207
GuGAuuGGAAAuGGAucAudTsdT
sense


 


1706-1725
9208
AUGAUCCAUUUCCAAUCAC
11208
AUGAUCcAUUUCcAAUcACdTsdT
antis


 


1708-1727
9209
GAUUGGAAAUGGAUCAUUU
11209
GAuuGGAAAuGGAucAuuudTsdT
sense


 


1708-1727
9210
AAAUGAUCCAUUUCCAAUC
11210
AAAUGAUCcAUUUCcAAUCdTsdT
antis


 


1724-1743
9211
UUUGGUGUGGUAUAUCAAG
11211
uuuGGuGuGGuAuAucAAGdTsdT
sense


 


1724-1743
9212
CUUGAUAUACCACACCAAA
11212
CUUGAuAuACcAcACcAAAdTsdT
antis


 


1725-1744
9213
UUGGUGUGGUAUAUCAAGC
11213
uuGGuGuGGuAuAucAAGcdTsdT
sense


 


1725-1744
9214
GCUUGAUAUACCACACCAA
11214
GCUUGAuAuACcAcACcAAdTsdT
antis


 


1727-1746
9215
GGUGUGGUAUAUCAAGCCA
11215
GGuGuGGuAuAucAAGccAdTsdT
sense


 


1727-1746
9216
UGGCUUGAUAUACCACACC
11216
UGGCUUGAuAuACcAcACCdTsdT
antis


 


1739-1758
9217
CAAGCCAAACUUUGUGAUU
11217
cAAGccAAAcuuuGuGAuudTsdT
sense


 


1739-1758
9218
AAUCACAAAGUUUGGCUUG
11218
AAUcAcAAAGUUUGGCUUGdTsdT
antis


 


1785-1804
9219
UUCUACAGGACAAGCGAUU
11219
uucuAcAGGAcAAGcGAuudTsdT
sense


 


1785-1804
9220
AAUCGCUUGUCCUGUAGAA
11220
AAUCGCUUGUCCUGuAGAAdTsdT
antis


 


1828-1847
9221
GAGAAAGCUAGACCACUGU
11221
GAGAAAGcuAGAccAcuGudTsdT
sense


 


1828-1847
9222
ACAGUGGUCUAGCUUUCUC
11222
AcAGUGGUCuAGCUUUCUCdTsdT
antis


 


1829-1848
9223
AGAAAGCUAGACCACUGUA
11223
AGAAAGcuAGAccAcuGuAdTsdT
sense


 


1829-1848
9224
UACAGUGGUCUAGCUUUCU
11224
uAcAGUGGUCuAGCUUUCUdTsdT
antis


 


1837-1856
9225
AGACCACUGUAACAUAGUC
11225
AGAccAcuGuAAcAuAGucdTsdT
sense


 


1837-1856
9226
GACUAUGUUACAGUGGUCU
11226
GACuAUGUuAcAGUGGUCUdTsdT
antis


 


1839-1858
9227
ACCACUGUAACAUAGUCCG
11227
AccAcuGuAAcAuAGuccGdTsdT
sense


 


1839-1858
9228
CGGACUAUGUUACAGUGGU
11228
CGGACuAUGUuAcAGUGGUdTsdT
antis


 


1841-1860
9229
CACUGUAACAUAGUCCGAC
11229
cAcuGuAAcAuAGuccGAcdTsdT
sense


 


1841-1860
9230
GUCGGACUAUGUUACAGUG
11230
GUCGGACuAUGUuAcAGUGdTsdT
antis


 


1864-1883
9231
GUAUUUCUUCUACUCGAGU
11231
GuAuuucuucuAcucGAGudTsdT
sense


 


1864-1883
9232
ACUCGAGUAGAAGAAAUAC
11232
ACUCGAGuAGAAGAAAuACdTsdT
antis


 


1865-1884
9233
UAUUUCUUCUACUCGAGUG
11233
uAuuucuucuAcucGAGuGdTsdT
sense


 


1865-1884
9234
CACUCGAGUAGAAGAAAUA
11234
cACUCGAGuAGAAGAAAuAdTsdT
antis


 


1867-1886
9235
UUUCUUCUACUCGAGUGGU
11235
uuucuucuAcucGAGuGGudTsdT
sense


 


1867-1886
9236
ACCACUCGAGUAGAAGAAA
11236
ACcACUCGAGuAGAAGAAAdTsdT
antis


 


1874-1893
9237
UACUCGAGUGGUGAGAAGA
11237
uAcucGAGuGGuGAGAAGAdTsdT
sense


 


1874-1893
9238
UCUUCUCACCACUCGAGUA
11238
UCUUCUcACcACUCGAGuAdTsdT
antis


 


1894-1913
9239
AGAUGAGGUCUACCUUAAC
11239
AGAuGAGGucuAccuuAAcdTsdT
sense


 


1894-1913
9240
GUUAAGGUAGACCUCAUCU
11240
GUuAAGGuAGACCUcAUCUdTsdT
antis


 


1921-1940
9241
GGACUAUGUUCCGGAGACA
11241
GGAcuAuGuuccGGAGAcAdTsdT
sense


 


1921-1940
9242
UGUCUCCGGAACAUAGUCC
11242
UGUCUCCGGAAcAuAGUCCdTsdT
antis


 


1954-1973
9243
CAGACACUAUAGUCGAGCC
11243
cAGAcAcuAuAGucGAGccdTsdT
sense


 


1954-1973
9244
GGCUCGACUAUAGUGUCUG
11244
GGCUCGACuAuAGUGUCUGdTsdT
antis


 


2006-2025
9245
UAUAUGUAUCAGCUGUUCA
11245
uAuAuGuAucAGcuGuucAdTsdT
sense


 


2006-2025
9246
UGAACAGCUGAUACAUAUA
11246
UGAAcAGCUGAuAcAuAuAdTsdT
antis


 


2017-2036
9247
GCUGUUCAGAAGUCUAGCC
11247
GcuGuucAGAAGucuAGccdTsdT
sense


 


2017-2036
9248
GGCUAGACUUCUGAACAGC
11248
GGCuAGACUUCUGAAcAGCdTsdT
antis


 


2019-2038
9249
UGUUCAGAAGUCUAGCCUA
11249
uGuucAGAAGucuAGccuAdTsdT
sense


 


2019-2038
9250
UAGGCUAGACUUCUGAACA
11250
uAGGCuAGACUUCUGAAcAdTsdT
antis


 


2026-2045
9251
AAGUCUAGCCUAUAUCCAU
11251
AAGucuAGccuAuAuccAudTsdT
sense


 


2026-2045
9252
AUGGAUAUAGGCUAGACUU
11252
AUGGAuAuAGGCuAGACUUdTsdT
antis


 


2052-2071
9253
GAAUCUGCCAUCGAGACAU
11253
GAAucuGccAucGAGAcAudTsdT
sense


 


2052-2071
9254
AUGUCUCGAUGGCAGAUUC
11254
AUGUCUCGAUGGcAGAUUCdTsdT
antis


 


2072-2091
9255
AAACCACAGAACCUCUUGU
11255
AAAccAcAGAAccucuuGudTsdT
sense


 


2072-2091
9256
ACAAGAGGUUCUGUGGUUU
11256
AcAAGAGGUUCUGUGGUUUdTsdT
antis


 


2082-2101
9257
ACCUCUUGUUGGAUCCUGA
11257
AccucuuGuuGGAuccuGAdTsdT
sense


 


2082-2101
9258
UCAGGAUCCAACAAGAGGU
11258
UcAGGAUCcAAcAAGAGGUdTsdT
antis


 


2088-2107
9259
UGUUGGAUCCUGAUACAGC
11259
uGuuGGAuccuGAuAcAGcdTsdT
sense


 


2088-2107
9260
GCUGUAUCAGGAUCCAACA
11260
GCUGuAUcAGGAUCcAAcAdTsdT
antis


 


2096-2115
9261
CCUGAUACAGCUGUAUUAA
11261
ccuGAuAcAGcuGuAuuAAdTsdT
sense


 


2096-2115
9262
UUAAUACAGCUGUAUCAGG
11262
UuAAuAcAGCUGuAUcAGGdTsdT
antis


 


2167-2186
9263
UUCAUAUAUCUGUUCUCGG
11263
uucAuAuAucuGuucucGGdTsdT
sense


 


2167-2186
9264
CCGAGAACAGAUAUAUGAA
11264
CCGAGAAcAGAuAuAUGAAdTsdT
antis


 


2192-2211
9265
AGGGCACCAGAGUUGAUCU
11265
AGGGcAccAGAGuuGAucudTsdT
sense


 


2192-2211
9266
AGAUCAACUCUGGUGCCCU
11266
AGAUcAACUCUGGUGCCCUdTsdT
antis


 


2213-2232
9267
GGAGCCACUGAUUACACGU
11267
GGAGccAcuGAuuAcAcGudTsdT
sense


 


2213-2232
9268
ACGUGUAAUCAGUGGCUCC
11268
ACGUGuAAUcAGUGGCUCCdTsdT
antis


 


2214-2233
9269
GAGCCACUGAUUACACGUC
11269
GAGccAcuGAuuAcAcGucdTsdT
sense


 


2214-2233
9270
GACGUGUAAUCAGUGGCUC
11270
GACGUGuAAUcAGUGGCUCdTsdT
antis


 


2225-2244
9271
UACACGUCCAGUAUAGAUG
11271
uAcAcGuccAGuAuAGAuGdTsdT
sense


 


2225-2244
9272
CAUCUAUACUGGACGUGUA
11272
cAUCuAuACUGGACGUGuAdTsdT
antis


 


2229-2248
9273
CGUCCAGUAUAGAUGUAUG
11273
cGuccAGuAuAGAuGuAuGdTsdT
sense


 


2229-2248
9274
CAUACAUCUAUACUGGACG
11274
cAuAcAUCuAuACUGGACGdTsdT
antis


 


2230-2249
9275
GUCCAGUAUAGAUGUAUGG
11275
GuccAGuAuAGAuGuAuGGdTsdT
sense


 


2230-2249
9276
CCAUACAUCUAUACUGGAC
11276
CcAuAcAUCuAuACUGGACdTsdT
antis


 


2233-2252
9277
CAGUAUAGAUGUAUGGUCU
11277
cAGuAuAGAuGuAuGGucudTsdT
sense


 


2233-2252
9278
AGACCAUACAUCUAUACUG
11278
AGACcAuAcAUCuAuACUGdTsdT
antis


 


2236-2255
9279
UAUAGAUGUAUGGUCUGCA
11279
uAuAGAuGuAuGGucuGcAdTsdT
sense


 


2236-2255
9280
UGCAGACCAUACAUCUAUA
11280
UGcAGACcAuAcAUCuAuAdTsdT
antis


 


2239-2258
9281
AGAUGUAUGGUCUGCAGGC
11281
AGAuGuAuGGucuGcAGGcdTsdT
sense


 


2239-2258
9282
GCCUGCAGACCAUACAUCU
11282
GCCUGcAGACcAuAcAUCUdTsdT
antis


 


2268-2287
9283
CUGAAUUGUUGCUAGGACA
11283
cuGAAuuGuuGcuAGGAcAdTsdT
sense


 


2268-2287
9284
UGUCCUAGCAACAAUUCAG
11284
UGUCCuAGcAAcAAUUcAGdTsdT
antis


 


2278-2297
9285
GCUAGGACAACCAAUAUUU
11285
GcuAGGAcAAccAAuAuuudTsdT
sense


 


2278-2297
9286
AAAUAUUGGUUGUCCUAGC
11286
AAAuAUUGGUUGUCCuAGCdTsdT
antis


 


2286-2305
9287
AACCAAUAUUUCCUGGGGA
11287
AAccAAuAuuuccuGGGGAdTsdT
sense


 


2286-2305
9288
UCCCCAGGAAAUAUUGGUU
11288
UCCCcAGGAAAuAUUGGUUdTsdT
antis


 


2339-2358
9289
GUCCUAGGAACACCAACAA
11289
GuccuAGGAAcAccAAcAAdTsdT
sense


 


2339-2358
9290
UUGUUGGUGUUCCUAGGAC
11290
UUGUUGGUGUUCCuAGGACdTsdT
antis


 


2340-2359
9291
UCCUAGGAACACCAACAAG
11291
uccuAGGAAcAccAAcAAGdTsdT
sense


 


2340-2359
9292
CUUGUUGGUGUUCCUAGGA
11292
CUUGUUGGUGUUCCuAGGAdTsdT
antis


 


2342-2361
9293
CUAGGAACACCAACAAGGG
11293
cuAGGAAcAccAAcAAGGGdTsdT
sense


 


2342-2361
9294
CCCUUGUUGGUGUUCCUAG
11294
CCCUUGUUGGUGUUCCuAGdTsdT
antis


 


2344-2363
9295
AGGAACACCAACAAGGGAG
11295
AGGAAcAccAAcAAGGGAGdTsdT
sense


 


2344-2363
9296
CUCCCUUGUUGGUGUUCCU
11296
CUCCCUUGUUGGUGUUCCUdTsdT
antis


 


2355-2374
9297
CAAGGGAGCAAAUUAGAGA
11297
cAAGGGAGcAAAuuAGAGAdTsdT
sense


 


2355-2374
9298
UCUCUAAUUUGCUCCCUUG
11298
UCUCuAAUUUGCUCCCUUGdTsdT
antis


 


2397-2416
9299
UCAAAUUCCCUCAAAUCAA
11299
ucAAAuucccucAAAucAAdTsdT
sense


 


2397-2416
9300
UUGAUUUGAGGGAAUUUGA
11300
UUGAUUUGAGGGAAUUUGAdTsdT
antis


 


2434-2453
9301
GGUCUUCCGGCCCCGAACU
11301
GGucuuccGGccccGAAcudTsdT
sense


 


2434-2453
9302
AGUUCGGGGCCGGAAGACC
11302
AGUUCGGGGCCGGAAGACCdTsdT
antis


 


2435-2454
9303
GUCUUCCGGCCCCGAACUC
11303
GucuuccGGccccGAAcucdTsdT
sense


 


2435-2454
9304
GAGUUCGGGGCCGGAAGAC
11304
GAGUUCGGGGCCGGAAGACdTsdT
antis


 


2437-2456
9305
CUUCCGGCCCCGAACUCCA
11305
cuuccGGccccGAAcuccAdTsdT
sense


 


2437-2456
9306
UGGAGUUCGGGGCCGGAAG
11306
UGGAGUUCGGGGCCGGAAGdTsdT
antis


 


2453-2472
9307
CCACCAGAGGCAAUUGCAC
11307
ccAccAGAGGcAAuuGcAcdTsdT
sense


 


2453-2472
9308
GUGCAAUUGCCUCUGGUGG
11308
GUGcAAUUGCCUCUGGUGGdTsdT
antis


 


2467-2486
9309
UGCACUGUGCAGCCGUCUG
11309
uGcAcuGuGcAGccGucuGdTsdT
sense


 


2467-2486
9310
CAGACGGCUGCACAGUGCA
11310
cAGACGGCUGcAcAGUGcAdTsdT
antis


 


2486-2505
9311
CUGGAGUACACACCUACCG
11311
cuGGAGuAcAcAccuAccGdTsdT
sense


 


2486-2505
9312
CGGUAGGUGUGUACUCCAG
11312
CGGuAGGUGUGuACUCcAGdTsdT
antis


 


2490-2509
9313
AGUACACACCUACCGCCCG
11313
AGuAcAcAccuAccGcccGdTsdT
sense


 


2490-2509
9314
CGGGCGGUAGGUGUGUACU
11314
CGGGCGGuAGGUGUGuACUdTsdT
antis


 


2505-2524
9315
CCCGGCUAACACCACUGGA
11315
cccGGcuAAcAccAcuGGAdTsdT
sense


 


2505-2524
9316
UCCAGUGGUGUUAGCCGGG
11316
UCcAGUGGUGUuAGCCGGGdTsdT
antis


 


2508-2527
9317
GGCUAACACCACUGGAAGC
11317
GGcuAAcAccAcuGGAAGcdTsdT
sense


 


2508-2527
9318
GCUUCCAGUGGUGUUAGCC
11318
GCUUCcAGUGGUGUuAGCCdTsdT
antis


 


1938-1957
9319
CAGUGUACAGAGUCGCCAG
11319
cAGuGuAcAGAGucGccAGdTsdT
sense


 


1938-1957
9320
CUGGCGACUCUGUACACUG
11320
CUGGCGACUCUGuAcACUGdTsdT
antis


 


1985-2004
9321
CCUGUGAUCUAUGUCAAGU
11321
ccuGuGAucuAuGucAAGudTsdT
sense


 


1985-2004
9322
ACUUGACAUAGAUCACAGG
11322
ACUUGAcAuAGAUcAcAGGdTsdT
antis


 


2164-2183
9323
UGUUUCAUAUAUCUGUUCU
11323
uGuuucAuAuAucuGuucudTsdT
sense


 


2164-2183
9324
AGAACAGAUAUAUGAAACA
11324
AGAAcAGAuAuAUGAAAcAdTsdT
antis


 


2263-2282
9325
GUUGGCUGAAUUGUUGCUA
11325
GuuGGcuGAAuuGuuGcuAdTsdT
sense


 


2263-2282
9326
UAGCAACAAUUCAGCCAAC
11326
uAGcAAcAAUUcAGCcAACdTsdT
antis


 


2367-2386
9327
UUAGAGAAAUGAACCCAAA
11327
uuAGAGAAAuGAAcccAAAdTsdT
sense


 


2367-2386
9328
UUUGGGUUCAUUUCUCUAA
11328
UUUGGGUUcAUUUCUCuAAdTsdT
antis


 


2395-2414
9329
AUUCAAAUUCCCUCAAAUC
11329
AuucAAAuucccucAAAucdTsdT
sense


 


2395-2414
9330
GAUUUGAGGGAAUUUGAAU
11330
GAUUUGAGGGAAUUUGAAUdTsdT
antis


 


1624-1643
9331
UGGCAGCAAGGUAACCACA
11331
uGGcAGcAAGGuAAccAcAdTsdT
sense


 


1624-1643
9332
UGUGGUUACCUUGCUGCCA
11332
UGUGGUuACCUUGCUGCcAdTsdT
antis


 


1686-1705
9333
UCAGUUAUACAGACACGAA
11333
ucAGuuAuAcAGAcAcGAAdTsdT
sense


 


1686-1705
9334
UUCGUGUCUGUAUAACUGA
11334
UUCGUGUCUGuAuAACUGAdTsdT
antis


 


1979-1998
9335
ACACUCCCUGUGAUCUAUG
11335
AcAcucccuGuGAucuAuGdTsdT
sense


 


1979-1998
9336
CAUAGAUCACAGGGAGUGU
11336
cAuAGAUcAcAGGGAGUGUdTsdT
antis


 


2080-2099
9337
GAACCUCUUGUUGGAUCCU
11337
GAAccucuuGuuGGAuccudTsdT
sense


 


2080-2099
9338
AGGAUCCAACAAGAGGUUC
11338
AGGAUCcAAcAAGAGGUUCdTsdT
antis


 


2091-2110
9339
UGGAUCCUGAUACAGCUGU
11339
uGGAuccuGAuAcAGcuGudTsdT
sense


 


2091-2110
9340
ACAGCUGUAUCAGGAUCCA
11340
AcAGCUGuAUcAGGAUCcAdTsdT
antis


 


2162-2181
9341
AAUGUUUCAUAUAUCUGUU
11341
AAuGuuucAuAuAucuGuudTsdT
sense


 


2162-2181
9342
AACAGAUAUAUGAAACAUU
11342
AAcAGAuAuAUGAAAcAUUdTsdT
antis


 


2175-2194
9343
UCUGUUCUCGGUACUACAG
11343
ucuGuucucGGuAcuAcAGdTsdT
sense


 


2175-2194
9344
CUGUAGUACCGAGAACAGA
11344
CUGuAGuACCGAGAAcAGAdTsdT
antis


 


2267-2286
9345
GCUGAAUUGUUGCUAGGAC
11345
GcuGAAuuGuuGcuAGGAcdTsdT
sense


 


2267-2286
9346
GUCCUAGCAACAAUUCAGC
11346
GUCCuAGcAAcAAUUcAGCdTsdT
antis


 


2309-2328
9347
GGUGUGGAUCAGUUGGUGG
11347
GGuGuGGAucAGuuGGuGGdTsdT
sense


 


2309-2328
9348
CCACCAACUGAUCCACACC
11348
CcACcAACUGAUCcAcACCdTsdT
antis


 


2451-2470
9349
CUCCACCAGAGGCAAUUGC
11349
cuccAccAGAGGcAAuuGcdTsdT
sense


 


2451-2470
9350
GCAAUUGCCUCUGGUGGAG
11350
GcAAUUGCCUCUGGUGGAGdTsdT
antis


 


1546-1565
9351
CACCUCCUUUGCGGAGAGC
11351
cAccuccuuuGcGGAGAGcdTsdT
sense


 


1546-1565
9352
GCUCUCCGCAAAGGAGGUG
11352
GCUCUCCGcAAAGGAGGUGdTsdT
antis


 


1936-1955
9353
GACAGUGUACAGAGUCGCC
11353
GAcAGuGuAcAGAGucGccdTsdT
sense


 


1936-1955
9354
GGCGACUCUGUACACUGUC
11354
GGCGACUCUGuAcACUGUCdTsdT
antis


 


1592-1611
9355
UUUGGUAGCAUGAAAGUUA
11355
uuuGGuAGcAuGAAAGuuAdTsdT
sense


 


1592-1611
9356
UAACUUUCAUGCUACCAAA
11356
uAACUUUcAUGCuACcAAAdTsdT
antis


 


1620-1639
9357
AAGAUGGCAGCAAGGUAAC
11357
AAGAuGGcAGcAAGGuAAcdTsdT
sense


 


1620-1639
9358
GUUACCUUGCUGCCAUCUU
11358
GUuACCUUGCUGCcAUCUUdTsdT
antis


 


1675-1694
9359
GCCACAGGAAGUCAGUUAU
11359
GccAcAGGAAGucAGuuAudTsdT
sense


 


1675-1694
9360
AUAACUGACUUCCUGUGGC
11360
AuAACUGACUUCCUGUGGCdTsdT
antis


 


1723-1742
9361
AUUUGGUGUGGUAUAUCAA
11361
AuuuGGuGuGGuAuAucAAdTsdT
sense


 


1723-1742
9362
UUGAUAUACCACACCAAAU
11362
UUGAuAuACcAcACcAAAUdTsdT
antis


 


1738-1757
9363
UCAAGCCAAACUUUGUGAU
11363
ucAAGccAAAcuuuGuGAudTsdT
sense


 


1738-1757
9364
AUCACAAAGUUUGGCUUGA
11364
AUcAcAAAGUUUGGCUUGAdTsdT
antis


 


1758-1777
9365
CUGGAGAACUGGUUGCCAU
11365
cuGGAGAAcuGGuuGccAudTsdT
sense


 


1758-1777
9366
AUGGCAACCAGUUCUCCAG
11366
AUGGcAACcAGUUCUCcAGdTsdT
antis


 


2027-2046
9367
AGUCUAGCCUAUAUCCAUU
11367
AGucuAGccuAuAuccAuudTsdT
sense


 


2027-2046
9368
AAUGGAUAUAGGCUAGACU
11368
AAUGGAuAuAGGCuAGACUdTsdT
antis


 


2083-2102
9369
CCUCUUGUUGGAUCCUGAU
11369
ccucuuGuuGGAuccuGAudTsdT
sense


 


2083-2102
9370
AUCAGGAUCCAACAAGAGG
11370
AUcAGGAUCcAAcAAGAGGdTsdT
antis


 


2097-2116
9371
CUGAUACAGCUGUAUUAAA
11371
cuGAuAcAGcuGuAuuAAAdTsdT
sense


 


2097-2116
9372
UUUAAUACAGCUGUAUCAG
11372
UUuAAuAcAGCUGuAUcAGdTsdT
antis


 


2104-2123
9373
AGCUGUAUUAAAACUCUGU
11373
AGcuGuAuuAAAAcucuGudTsdT
sense


 


2104-2123
9374
ACAGAGUUUUAAUACAGCU
11374
AcAGAGUUUuAAuAcAGCUdTsdT
antis


 


2208-2227
9375
UCUUUGGAGCCACUGAUUA
11375
ucuuuGGAGccAcuGAuuAdTsdT
sense


 


2208-2227
9376
UAAUCAGUGGCUCCAAAGA
11376
uAAUcAGUGGCUCcAAAGAdTsdT
antis


 


2210-2229
9377
UUUGGAGCCACUGAUUACA
11377
uuuGGAGccAcuGAuuAcAdTsdT
sense


 


2210-2229
9378
UGUAAUCAGUGGCUCCAAA
11378
UGuAAUcAGUGGCUCcAAAdTsdT
antis


 


2304-2323
9379
ACAGUGGUGUGGAUCAGUU
11379
AcAGuGGuGuGGAucAGuudTsdT
sense


 


2304-2323
9380
AACUGAUCCACACCACUGU
11380
AACUGAUCcAcACcACUGUdTsdT
antis


 


2328-2347
9381
AAAUAAUAAAGGUCCUAGG
11381
AAAuAAuAAAGGuccuAGGdTsdT
sense


 


2328-2347
9382
CCUAGGACCUUUAUUAUUU
11382
CCuAGGACCUUuAUuAUUUdTsdT
antis


 


2390-2409
9383
ACAGAAUUCAAAUUCCCUC
11383
AcAGAAuucAAAuucccucdTsdT
sense


 


2390-2409
9384
GAGGGAAUUUGAAUUCUGU
11384
GAGGGAAUUUGAAUUCUGUdTsdT
antis


 


2018-2037
9385
CUGUUCAGAAGUCUAGCCU
11385
cuGuucAGAAGucuAGccudTsdT
sense


 


2018-2037
9386
AGGCUAGACUUCUGAACAG
11386
AGGCuAGACUUCUGAAcAGdTsdT
antis


 


2338-2357
9387
GGUCCUAGGAACACCAACA
11387
GGuccuAGGAAcAccAAcAdTsdT
sense


 


2338-2357
9388
UGUUGGUGUUCCUAGGACC
11388
UGUUGGUGUUCCuAGGACCdTsdT
antis


 


2351-2370
9389
CCAACAAGGGAGCAAAUUA
11389
ccAAcAAGGGAGcAAAuuAdTsdT
sense


 


2351-2370
9390
UAAUUUGCUCCCUUGUUGG
11390
uAAUUUGCUCCCUUGUUGGdTsdT
antis


 


2433-2452
9391
AGGUCUUCCGGCCCCGAAC
11391
AGGucuuccGGccccGAAcdTsdT
sense


 


2433-2452
9392
GUUCGGGGCCGGAAGACCU
11392
GUUCGGGGCCGGAAGACCUdTsdT
antis


 


2180-2199
9393
UCUCGGUACUACAGGGCAC
11393
ucucGGuAcuAcAGGGcAcdTsdT
sense


 


2180-2199
9394
GUGCCCUGUAGUACCGAGA
11394
GUGCCCUGuAGuACCGAGAdTsdT
antis


 


1644-1663
9395
UAGUGGCAACUCCUGGCCA
11395
uAGuGGcAAcuccuGGccAdTsdT
sense


 


1644-1663
9396
UGGCCAGGAGUUGCCACUA
11396
UGGCcAGGAGUUGCcACuAdTsdT
antis


 


1827-1846
9397
UGAGAAAGCUAGACCACUG
11397
uGAGAAAGcuAGAccAcuGdTsdT
sense


 


1827-1846
9398
CAGUGGUCUAGCUUUCUCA
11398
cAGUGGUCuAGCUUUCUcAdTsdT
antis


 


2098-2117
9399
UGAUACAGCUGUAUUAAAA
11399
uGAuAcAGcuGuAuuAAAAdTsdT
sense


 


2098-2117
9400
UUUUAAUACAGCUGUAUCA
11400
UUUuAAuAcAGCUGuAUcAdTsdT
antis


 


2254-2273
9401
AGGCUGUGUGUUGGCUGAA
11401
AGGcuGuGuGuuGGcuGAAdTsdT
sense


 


2254-2273
9402
UUCAGCCAACACACAGCCU
11402
UUcAGCcAAcAcAcAGCCUdTsdT
antis


 


1674-1693
9403
GGCCACAGGAAGUCAGUUA
11403
GGccAcAGGAAGucAGuuAdTsdT
sense


 


1674-1693
9404
UAACUGACUUCCUGUGGCC
11404
uAACUGACUUCCUGUGGCCdTsdT
antis


 


2495-2514
9405
ACACCUACCGCCCGGCUAA
11405
AcAccuAccGcccGGcuAAdTsdT
sense


 


2495-2514
9406
UUAGCCGGGCGGUAGGUGU
11406
UuAGCCGGGCGGuAGGUGUdTsdT
antis


 


1794-1813
9407
ACAAGCGAUUUAAGAACCG
11407
AcAAGcGAuuuAAGAAccGdTsdT
sense


 


1794-1813
9408
CGGUUCUUAAAUCGCUUGU
11408
CGGUUCUuAAAUCGCUUGUdTsdT
antis


 


1861-1880
9409
GCGGUAUUUCUUCUACUCG
11409
GcGGuAuuucuucuAcucGdTsdT
sense


 


1861-1880
9410
CGAGUAGAAGAAAUACCGC
11410
CGAGuAGAAGAAAuACCGCdTsdT
antis


 


1989-2008
9411
UGAUCUAUGUCAAGUUGUA
11411
uGAucuAuGucAAGuuGuAdTsdT
sense


 


1989-2008
9412
UACAACUUGACAUAGAUCA
11412
uAcAACUUGAcAuAGAUcAdTsdT
antis


 


2025-2044
9413
GAAGUCUAGCCUAUAUCCA
11413
GAAGucuAGccuAuAuccAdTsdT
sense


 


2025-2044
9414
UGGAUAUAGGCUAGACUUC
11414
UGGAuAuAGGCuAGACUUCdTsdT
antis


 


2028-2047
9415
GUCUAGCCUAUAUCCAUUC
11415
GucuAGccuAuAuccAuucdTsdT
sense


 


2028-2047
9416
GAAUGGAUAUAGGCUAGAC
11416
GAAUGGAuAuAGGCuAGACdTsdT
antis


 


2029-2048
9417
UCUAGCCUAUAUCCAUUCC
11417
ucuAGccuAuAuccAuuccdTsdT
sense


 


2029-2048
9418
GGAAUGGAUAUAGGCUAGA
11418
GGAAUGGAuAuAGGCuAGAdTsdT
antis


 


2275-2294
9419
GUUGCUAGGACAACCAAUA
11419
GuuGcuAGGAcAAccAAuAdTsdT
sense


 


2275-2294
9420
UAUUGGUUGUCCUAGCAAC
11420
uAUUGGUUGUCCuAGcAACdTsdT
antis


 


1593-1612
9421
UUGGUAGCAUGAAAGUUAG
11421
uuGGuAGcAuGAAAGuuAGdTsdT
sense


 


1593-1612
9422
CUAACUUUCAUGCUACCAA
11422
CuAACUUUcAUGCuACcAAdTsdT
antis


 


1690-1709
9423
UUAUACAGACACGAAAGUG
11423
uuAuAcAGAcAcGAAAGuGdTsdT
sense


 


1690-1709
9424
CACUUUCGUGUCUGUAUAA
11424
cACUUUCGUGUCUGuAuAAdTsdT
antis


 


1795-1814
9425
CAAGCGAUUUAAGAACCGA
11425
cAAGcGAuuuAAGAAccGAdTsdT
sense


 


1795-1814
9426
UCGGUUCUUAAAUCGCUUG
11426
UCGGUUCUuAAAUCGCUUGdTsdT
antis


 


1822-1841
9427
GAUCAUGAGAAAGCUAGAC
11427
GAucAuGAGAAAGcuAGAcdTsdT
sense


 


1822-1841
9428
GUCUAGCUUUCUCAUGAUC
11428
GUCuAGCUUUCUcAUGAUCdTsdT
antis


 


1901-1920
9429
GUCUACCUUAACCUGGUGC
11429
GucuAccuuAAccuGGuGcdTsdT
sense


 


1901-1920
9430
GCACCAGGUUAAGGUAGAC
11430
GcACcAGGUuAAGGuAGACdTsdT
antis


 


1926-1945
9431
AUGUUCCGGAGACAGUGUA
11431
AuGuuccGGAGAcAGuGuAdTsdT
sense


 


1926-1945
9432
UACACUGUCUCCGGAACAU
11432
uAcACUGUCUCCGGAAcAUdTsdT
antis


 


1947-1966
9433
GAGUCGCCAGACACUAUAG
11433
GAGucGccAGAcAcuAuAGdTsdT
sense


 


1947-1966
9434
CUAUAGUGUCUGGCGACUC
11434
CuAuAGUGUCUGGCGACUCdTsdT
antis


 


1949-1968
9435
GUCGCCAGACACUAUAGUC
11435
GucGccAGAcAcuAuAGucdTsdT
sense


 


1949-1968
9436
GACUAUAGUGUCUGGCGAC
11436
GACuAuAGUGUCUGGCGACdTsdT
antis


 


1956-1975
9437
GACACUAUAGUCGAGCCAA
11437
GAcAcuAuAGucGAGccAAdTsdT
sense


 


1956-1975
9438
UUGGCUCGACUAUAGUGUC
11438
UUGGCUCGACuAuAGUGUCdTsdT
antis


 


1977-1996
9439
AGACACUCCCUGUGAUCUA
11439
AGAcAcucccuGuGAucuAdTsdT
sense


 


1977-1996
9440
UAGAUCACAGGGAGUGUCU
11440
uAGAUcAcAGGGAGUGUCUdTsdT
antis


 


1990-2009
9441
GAUCUAUGUCAAGUUGUAU
11441
GAucuAuGucAAGuuGuAudTsdT
sense


 


1990-2009
9442
AUACAACUUGACAUAGAUC
11442
AuAcAACUUGAcAuAGAUCdTsdT
antis


 


2008-2027
9443
UAUGUAUCAGCUGUUCAGA
11443
uAuGuAucAGcuGuucAGAdTsdT
sense


 


2008-2027
9444
UCUGAACAGCUGAUACAUA
11444
UCUGAAcAGCUGAuAcAuAdTsdT
antis


 


2047-2066
9445
CUUUGGAAUCUGCCAUCGA
11445
cuuuGGAAucuGccAucGAdTsdT
sense


 


2047-2066
9446
UCGAUGGCAGAUUCCAAAG
11446
UCGAUGGcAGAUUCcAAAGdTsdT
antis


 


2187-2206
9447
ACUACAGGGCACCAGAGUU
11447
AcuAcAGGGcAccAGAGuudTsdT
sense


 


2187-2206
9448
AACUCUGGUGCCCUGUAGU
11448
AACUCUGGUGCCCUGuAGUdTsdT
antis


 


2307-2326
9449
GUGGUGUGGAUCAGUUGGU
11449
GuGGuGuGGAucAGuuGGudTsdT
sense


 


2307-2326
9450
ACCAACUGAUCCACACCAC
11450
ACcAACUGAUCcAcACcACdTsdT
antis


 


2357-2376
9451
AGGGAGCAAAUUAGAGAAA
11451
AGGGAGcAAAuuAGAGAAAdTsdT
sense


 


2357-2376
9452
UUUCUCUAAUUUGCUCCCU
11452
UUUCUCuAAUUUGCUCCCUdTsdT
antis


 


2405-2424
9453
CCUCAAAUCAAGGCACAUC
11453
ccucAAAucAAGGcAcAucdTsdT
sense


 


2405-2424
9454
GAUGUGCCUUGAUUUGAGG
11454
GAUGUGCCUUGAUUUGAGGdTsdT
antis


 


2483-2502
9455
CUGCUGGAGUACACACCUA
11455
cuGcuGGAGuAcAcAccuAdTsdT
sense


 


2483-2502
9456
UAGGUGUGUACUCCAGCAG
11456
uAGGUGUGuACUCcAGcAGdTsdT
antis


 


1629-1648
9457
GCAAGGUAACCACAGUAGU
11457
GcAAGGuAAccAcAGuAGudTsdT
sense


 


1629-1648
9458
ACUACUGUGGUUACCUUGC
11458
ACuACUGUGGUuACCUUGCdTsdT
antis


 


1972-1991
9459
CAAGCAGACACUCCCUGUG
11459
cAAGcAGAcAcucccuGuGdTsdT
sense


 


1972-1991
9460
CACAGGGAGUGUCUGCUUG
11460
cAcAGGGAGUGUCUGCUUGdTsdT
antis


 


1622-1641
9461
GAUGGCAGCAAGGUAACCA
11461
GAuGGcAGcAAGGuAAccAdTsdT
sense


 


1622-1641
9462
UGGUUACCUUGCUGCCAUC
11462
UGGUuACCUUGCUGCcAUCdTsdT
antis


 


1635-1654
9463
UAACCACAGUAGUGGCAAC
11463
uAAccAcAGuAGuGGcAAcdTsdT
sense


 


1635-1654
9464
GUUGCCACUACUGUGGUUA
11464
GUUGCcACuACUGUGGUuAdTsdT
antis


 


1790-1809
9465
CAGGACAAGCGAUUUAAGA
11465
cAGGAcAAGcGAuuuAAGAdTsdT
sense


 


1790-1809
9466
UCUUAAAUCGCUUGUCCUG
11466
UCUuAAAUCGCUUGUCCUGdTsdT
antis


 


1818-1837
9467
UCCAGAUCAUGAGAAAGCU
11467
uccAGAucAuGAGAAAGcudTsdT
sense


 


1818-1837
9468
AGCUUUCUCAUGAUCUGGA
11468
AGCUUUCUcAUGAUCUGGAdTsdT
antis


 


1854-1873
9469
UCCGACUGCGGUAUUUCUU
11469
uccGAcuGcGGuAuuucuudTsdT
sense


 


1854-1873
9470
AAGAAAUACCGCAGUCGGA
11470
AAGAAAuACCGcAGUCGGAdTsdT
antis


 


1942-1961
9471
GUACAGAGUCGCCAGACAC
11471
GuAcAGAGucGccAGAcAcdTsdT
sense


 


1942-1961
9472
GUGUCUGGCGACUCUGUAC
11472
GUGUCUGGCGACUCUGuACdTsdT
antis


 


1988-2007
9473
GUGAUCUAUGUCAAGUUGU
11473
GuGAucuAuGucAAGuuGudTsdT
sense


 


1988-2007
9474
ACAACUUGACAUAGAUCAC
11474
AcAACUUGAcAuAGAUcACdTsdT
antis


 


2055-2074
9475
UCUGCCAUCGAGACAUUAA
11475
ucuGccAucGAGAcAuuAAdTsdT
sense


 


2055-2074
9476
UUAAUGUCUCGAUGGCAGA
11476
UuAAUGUCUCGAUGGcAGAdTsdT
antis


 


2217-2236
9477
CCACUGAUUACACGUCCAG
11477
ccAcuGAuuAcAcGuccAGdTsdT
sense


 


2217-2236
9478
CUGGACGUGUAAUCAGUGG
11478
CUGGACGUGuAAUcAGUGGdTsdT
antis


 


2235-2254
9479
GUAUAGAUGUAUGGUCUGC
11479
GuAuAGAuGuAuGGucuGcdTsdT
sense


 


2235-2254
9480
GCAGACCAUACAUCUAUAC
11480
GcAGACcAuAcAUCuAuACdTsdT
antis


 


2258-2277
9481
UGUGUGUUGGCUGAAUUGU
11481
uGuGuGuuGGcuGAAuuGudTsdT
sense


 


2258-2277
9482
ACAAUUCAGCCAACACACA
11482
AcAAUUcAGCcAAcAcAcAdTsdT
antis


 


2269-2288
9483
UGAAUUGUUGCUAGGACAA
11483
uGAAuuGuuGcuAGGAcAAdTsdT
sense


 


2269-2288
9484
UUGUCCUAGCAACAAUUCA
11484
UUGUCCuAGcAAcAAUUcAdTsdT
antis


 


2404-2423
9485
CCCUCAAAUCAAGGCACAU
11485
cccucAAAucAAGGcAcAudTsdT
sense


 


2404-2423
9486
AUGUGCCUUGAUUUGAGGG
11486
AUGUGCCUUGAUUUGAGGGdTsdT
antis


 


2423-2442
9487
CCUUGGACAAAGGUCUUCC
11487
ccuuGGAcAAAGGucuuccdTsdT
sense


 


2423-2442
9488
GGAAGACCUUUGUCCAAGG
11488
GGAAGACCUUUGUCcAAGGdTsdT
antis


 


2455-2474
9489
ACCAGAGGCAAUUGCACUG
11489
AccAGAGGcAAuuGcAcuGdTsdT
sense


 


2455-2474
9490
CAGUGCAAUUGCCUCUGGU
11490
cAGUGcAAUUGCCUCUGGUdTsdT
antis


 


1586-1605
9491
UCAGCUUUUGGUAGCAUGA
11491
ucAGcuuuuGGuAGcAuGAdTsdT
sense


 


1586-1605
9492
UCAUGCUACCAAAAGCUGA
11492
UcAUGCuACcAAAAGCUGAdTsdT
antis


 


1601-1620
9493
AUGAAAGUUAGCAGAGAUA
11493
AuGAAAGuuAGcAGAGAuAdTsdT
sense


 


1601-1620
9494
UAUCUCUGCUAACUUUCAU
11494
uAUCUCUGCuAACUUUcAUdTsdT
antis


 


1621-1640
9495
AGAUGGCAGCAAGGUAACC
11495
AGAuGGcAGcAAGGuAAccdTsdT
sense


 


1621-1640
9496
GGUUACCUUGCUGCCAUCU
11496
GGUuACCUUGCUGCcAUCUdTsdT
antis


 


1626-1645
9497
GCAGCAAGGUAACCACAGU
11497
GcAGcAAGGuAAccAcAGudTsdT
sense


 


1626-1645
9498
ACUGUGGUUACCUUGCUGC
11498
ACUGUGGUuACCUUGCUGCdTsdT
antis


 


1658-1677
9499
GGCCAGGGUCCUGACAGGC
11499
GGccAGGGuccuGAcAGGcdTsdT
sense


 


1658-1677
9500
GCCUGUCAGGACCCUGGCC
11500
GCCUGUcAGGACCCUGGCCdTsdT
antis


 


1683-1702
9501
AAGUCAGUUAUACAGACAC
11501
AAGucAGuuAuAcAGAcAcdTsdT
sense


 


1683-1702
9502
GUGUCUGUAUAACUGACUU
11502
GUGUCUGuAuAACUGACUUdTsdT
antis


 


1709-1728
9503
AUUGGAAAUGGAUCAUUUG
11503
AuuGGAAAuGGAucAuuuGdTsdT
sense


 


1709-1728
9504
CAAAUGAUCCAUUUCCAAU
11504
cAAAUGAUCcAUUUCcAAUdTsdT
antis


 


1710-1729
9505
UUGGAAAUGGAUCAUUUGG
11505
uuGGAAAuGGAucAuuuGGdTsdT
sense


 


1710-1729
9506
CCAAAUGAUCCAUUUCCAA
11506
CcAAAUGAUCcAUUUCcAAdTsdT
antis


 


1726-1745
9507
UGGUGUGGUAUAUCAAGCC
11507
uGGuGuGGuAuAucAAGccdTsdT
sense


 


1726-1745
9508
GGCUUGAUAUACCACACCA
11508
GGCUUGAuAuACcAcACcAdTsdT
antis


 


1740-1759
9509
AAGCCAAACUUUGUGAUUC
11509
AAGccAAAcuuuGuGAuucdTsdT
sense


 


1740-1759
9510
GAAUCACAAAGUUUGGCUU
11510
GAAUcAcAAAGUUUGGCUUdTsdT
antis


 


1754-1773
9511
GAUUCUGGAGAACUGGUUG
11511
GAuucuGGAGAAcuGGuuGdTsdT
sense


 


1754-1773
9512
CAACCAGUUCUCCAGAAUC
11512
cAACcAGUUCUCcAGAAUCdTsdT
antis


 


1755-1774
9513
AUUCUGGAGAACUGGUUGC
11513
AuucuGGAGAAcuGGuuGcdTsdT
sense


 


1755-1774
9514
GCAACCAGUUCUCCAGAAU
11514
GcAACcAGUUCUCcAGAAUdTsdT
antis


 


1757-1776
9515
UCUGGAGAACUGGUUGCCA
11515
ucuGGAGAAcuGGuuGccAdTsdT
sense


 


1757-1776
9516
UGGCAACCAGUUCUCCAGA
11516
UGGcAACcAGUUCUCcAGAdTsdT
antis


 


1786-1805
9517
UCUACAGGACAAGCGAUUU
11517
ucuAcAGGAcAAGcGAuuudTsdT
sense


 


1786-1805
9518
AAAUCGCUUGUCCUGUAGA
11518
AAAUCGCUUGUCCUGuAGAdTsdT
antis


 


1834-1853
9519
GCUAGACCACUGUAACAUA
11519
GcuAGAccAcuGuAAcAuAdTsdT
sense


 


1834-1853
9520
UAUGUUACAGUGGUCUAGC
11520
uAUGUuAcAGUGGUCuAGCdTsdT
antis


 


1886-1905
9521
GAGAAGAAAGAUGAGGUCU
11521
GAGAAGAAAGAuGAGGucudTsdT
sense


 


1886-1905
9522
AGACCUCAUCUUUCUUCUC
11522
AGACCUcAUCUUUCUUCUCdTsdT
antis


 


1887-1906
9523
AGAAGAAAGAUGAGGUCUA
11523
AGAAGAAAGAuGAGGucuAdTsdT
sense


 


1887-1906
9524
UAGACCUCAUCUUUCUUCU
11524
uAGACCUcAUCUUUCUUCUdTsdT
antis


 


1892-1911
9525
AAAGAUGAGGUCUACCUUA
11525
AAAGAuGAGGucuAccuuAdTsdT
sense


 


1892-1911
9526
UAAGGUAGACCUCAUCUUU
11526
uAAGGuAGACCUcAUCUUUdTsdT
antis


 


1893-1912
9527
AAGAUGAGGUCUACCUUAA
11527
AAGAuGAGGucuAccuuAAdTsdT
sense


 


1893-1912
9528
UUAAGGUAGACCUCAUCUU
11528
UuAAGGuAGACCUcAUCUUdTsdT
antis


 


1925-1944
9529
UAUGUUCCGGAGACAGUGU
11529
uAuGuuccGGAGAcAGuGudTsdT
sense


 


1925-1944
9530
ACACUGUCUCCGGAACAUA
11530
AcACUGUCUCCGGAAcAuAdTsdT
antis


 


1937-1956
9531
ACAGUGUACAGAGUCGCCA
11531
AcAGuGuAcAGAGucGccAdTsdT
sense


 


1937-1956
9532
UGGCGACUCUGUACACUGU
11532
UGGCGACUCUGuAcACUGUdTsdT
antis


 


1978-1997
9533
GACACUCCCUGUGAUCUAU
11533
GAcAcucccuGuGAucuAudTsdT
sense


 


1978-1997
9534
AUAGAUCACAGGGAGUGUC
11534
AuAGAUcAcAGGGAGUGUCdTsdT
antis


 


1980-1999
9535
CACUCCCUGUGAUCUAUGU
11535
cAcucccuGuGAucuAuGudTsdT
sense


 


1980-1999
9536
ACAUAGAUCACAGGGAGUG
11536
AcAuAGAUcAcAGGGAGUGdTsdT
antis


 


2005-2024
9537
GUAUAUGUAUCAGCUGUUC
11537
GuAuAuGuAucAGcuGuucdTsdT
sense


 


2005-2024
9538
GAACAGCUGAUACAUAUAC
11538
GAAcAGCUGAuAcAuAuACdTsdT
antis


 


2074-2093
9539
ACCACAGAACCUCUUGUUG
11539
AccAcAGAAccucuuGuuGdTsdT
sense


 


2074-2093
9540
CAACAAGAGGUUCUGUGGU
11540
cAAcAAGAGGUUCUGUGGUdTsdT
antis


 


2081-2100
9541
AACCUCUUGUUGGAUCCUG
11541
AAccucuuGuuGGAuccuGdTsdT
sense


 


2081-2100
9542
CAGGAUCCAACAAGAGGUU
11542
cAGGAUCcAAcAAGAGGUUdTsdT
antis


 


2094-2113
9543
AUCCUGAUACAGCUGUAUU
11543
AuccuGAuAcAGcuGuAuudTsdT
sense


 


2094-2113
9544
AAUACAGCUGUAUCAGGAU
11544
AAuAcAGCUGuAUcAGGAUdTsdT
antis


 


2101-2120
9545
UACAGCUGUAUUAAAACUC
11545
uAcAGcuGuAuuAAAAcucdTsdT
sense


 


2101-2120
9546
GAGUUUUAAUACAGCUGUA
11546
GAGUUUuAAuAcAGCUGuAdTsdT
antis


 


2138-2157
9547
AAGCAGCUGGUCCGAGGAG
11547
AAGcAGcuGGuccGAGGAGdTsdT
sense


 


2138-2157
9548
CUCCUCGGACCAGCUGCUU
11548
CUCCUCGGACcAGCUGCUUdTsdT
antis


 


2161-2180
9549
CAAUGUUUCAUAUAUCUGU
11549
cAAuGuuucAuAuAucuGudTsdT
sense


 


2161-2180
9550
ACAGAUAUAUGAAACAUUG
11550
AcAGAuAuAUGAAAcAUUGdTsdT
antis


 


2171-2190
9551
UAUAUCUGUUCUCGGUACU
11551
uAuAucuGuucucGGuAcudTsdT
sense


 


2171-2190
9552
AGUACCGAGAACAGAUAUA
11552
AGuACCGAGAAcAGAuAuAdTsdT
antis


 


2178-2197
9553
GUUCUCGGUACUACAGGGC
11553
GuucucGGuAcuAcAGGGcdTsdT
sense


 


2178-2197
9554
GCCCUGUAGUACCGAGAAC
11554
GCCCUGuAGuACCGAGAACdTsdT
antis


 


2193-2212
9555
GGGCACCAGAGUUGAUCUU
11555
GGGcAccAGAGuuGAucuudTsdT
sense


 


2193-2212
9556
AAGAUCAACUCUGGUGCCC
11556
AAGAUcAACUCUGGUGCCCdTsdT
antis


 


2197-2216
9557
ACCAGAGUUGAUCUUUGGA
11557
AccAGAGuuGAucuuuGGAdTsdT
sense


 


2197-2216
9558
UCCAAAGAUCAACUCUGGU
11558
UCcAAAGAUcAACUCUGGUdTsdT
antis


 


2209-2228
9559
CUUUGGAGCCACUGAUUAC
11559
cuuuGGAGccAcuGAuuAcdTsdT
sense


 


2209-2228
9560
GUAAUCAGUGGCUCCAAAG
11560
GuAAUcAGUGGCUCcAAAGdTsdT
antis


 


2215-2234
9561
AGCCACUGAUUACACGUCC
11561
AGccAcuGAuuAcAcGuccdTsdT
sense


 


2215-2234
9562
GGACGUGUAAUCAGUGGCU
11562
GGACGUGuAAUcAGUGGCUdTsdT
antis


 


2231-2250
9563
UCCAGUAUAGAUGUAUGGU
11563
uccAGuAuAGAuGuAuGGudTsdT
sense


 


2231-2250
9564
ACCAUACAUCUAUACUGGA
11564
ACcAuAcAUCuAuACUGGAdTsdT
antis


 


2308-2327
9565
UGGUGUGGAUCAGUUGGUG
11565
uGGuGuGGAucAGuuGGuGdTsdT
sense


 


2308-2327
9566
CACCAACUGAUCCACACCA
11566
cACcAACUGAUCcAcACcAdTsdT
antis


 


2334-2353
9567
UAAAGGUCCUAGGAACACC
11567
uAAAGGuccuAGGAAcAccdTsdT
sense


 


2334-2353
9568
GGUGUUCCUAGGACCUUUA
11568
GGUGUUCCuAGGACCUUuAdTsdT
antis


 


2336-2355
9569
AAGGUCCUAGGAACACCAA
11569
AAGGuccuAGGAAcAccAAdTsdT
sense


 


2336-2355
9570
UUGGUGUUCCUAGGACCUU
11570
UUGGUGUUCCuAGGACCUUdTsdT
antis


 


2337-2356
9571
AGGUCCUAGGAACACCAAC
11571
AGGuccuAGGAAcAccAAcdTsdT
sense


 


2337-2356
9572
GUUGGUGUUCCUAGGACCU
11572
GUUGGUGUUCCuAGGACCUdTsdT
antis


 


2343-2362
9573
UAGGAACACCAACAAGGGA
11573
uAGGAAcAccAAcAAGGGAdTsdT
sense


 


2343-2362
9574
UCCCUUGUUGGUGUUCCUA
11574
UCCCUUGUUGGUGUUCCuAdTsdT
antis


 


2352-2371
9575
CAACAAGGGAGCAAAUUAG
11575
cAAcAAGGGAGcAAAuuAGdTsdT
sense


 


2352-2371
9576
CUAAUUUGCUCCCUUGUUG
11576
CuAAUUUGCUCCCUUGUUGdTsdT
antis


 


2370-2389
9577
GAGAAAUGAACCCAAAUUA
11577
GAGAAAuGAAcccAAAuuAdTsdT
sense


 


2370-2389
9578
UAAUUUGGGUUCAUUUCUC
11578
uAAUUUGGGUUcAUUUCUCdTsdT
antis


 


2385-2404
9579
AUUAUACAGAAUUCAAAUU
11579
AuuAuAcAGAAuucAAAuudTsdT
sense


 


2385-2404
9580
AAUUUGAAUUCUGUAUAAU
11580
AAUUUGAAUUCUGuAuAAUdTsdT
antis


 


2392-2411
9581
AGAAUUCAAAUUCCCUCAA
11581
AGAAuucAAAuucccucAAdTsdT
sense


 


2392-2411
9582
UUGAGGGAAUUUGAAUUCU
11582
UUGAGGGAAUUUGAAUUCUdTsdT
antis


 


2393-2412
9583
GAAUUCAAAUUCCCUCAAA
11583
GAAuucAAAuucccucAAAdTsdT
sense


 


2393-2412
9584
UUUGAGGGAAUUUGAAUUC
11584
UUUGAGGGAAUUUGAAUUCdTsdT
antis


 


2403-2422
9585
UCCCUCAAAUCAAGGCACA
11585
ucccucAAAucAAGGcAcAdTsdT
sense


 


2403-2422
9586
UGUGCCUUGAUUUGAGGGA
11586
UGUGCCUUGAUUUGAGGGAdTsdT
antis


 


2421-2440
9587
AUCCUUGGACAAAGGUCUU
11587
AuccuuGGAcAAAGGucuudTsdT
sense


 


2421-2440
9588
AAGACCUUUGUCCAAGGAU
11588
AAGACCUUUGUCcAAGGAUdTsdT
antis


 


2424-2443
9589
CUUGGACAAAGGUCUUCCG
11589
cuuGGAcAAAGGucuuccGdTsdT
sense


 


2424-2443
9590
CGGAAGACCUUUGUCCAAG
11590
CGGAAGACCUUUGUCcAAGdTsdT
antis


 


2454-2473
9591
CACCAGAGGCAAUUGCACU
11591
cAccAGAGGcAAuuGcAcudTsdT
sense


 


2454-2473
9592
AGUGCAAUUGCCUCUGGUG
11592
AGUGcAAUUGCCUCUGGUGdTsdT
antis


 


2468-2487
9593
GCACUGUGCAGCCGUCUGC
11593
GcAcuGuGcAGccGucuGcdTsdT
sense


 


2468-2487
9594
GCAGACGGCUGCACAGUGC
11594
GcAGACGGCUGcAcAGUGCdTsdT
antis


 


2469-2488
9595
CACUGUGCAGCCGUCUGCU
11595
cAcuGuGcAGccGucuGcudTsdT
sense


 


2469-2488
9596
AGCAGACGGCUGCACAGUG
11596
AGcAGACGGCUGcAcAGUGdTsdT
antis


 


2516-2535
9597
CCACUGGAAGCUUGUGCAC
11597
ccAcuGGAAGcuuGuGcAcdTsdT
sense


 


2516-2535
9598
GUGCACAAGCUUCCAGUGG
11598
GUGcAcAAGCUUCcAGUGGdTsdT
antis


 


1559-1578
9599
GAGAGCUGCAAGCCAGUGC
11599
GAGAGcuGcAAGccAGuGcdTsdT
sense


 


1559-1578
9600
GCACUGGCUUGCAGCUCUC
11600
GcACUGGCUUGcAGCUCUCdTsdT
antis


 


1676-1695
9601
CCACAGGAAGUCAGUUAUA
11601
ccAcAGGAAGucAGuuAuAdTsdT
sense


 


1676-1695
9602
UAUAACUGACUUCCUGUGG
11602
uAuAACUGACUUCCUGUGGdTsdT
antis


 


1896-1915
9603
AUGAGGUCUACCUUAACCU
11603
AuGAGGucuAccuuAAccudTsdT
sense


 


1896-1915
9604
AGGUUAAGGUAGACCUCAU
11604
AGGUuAAGGuAGACCUcAUdTsdT
antis


 


2262-2281
9605
UGUUGGCUGAAUUGUUGCU
11605
uGuuGGcuGAAuuGuuGcudTsdT
sense


 


2262-2281
9606
AGCAACAAUUCAGCCAACA
11606
AGcAAcAAUUcAGCcAAcAdTsdT
antis


 


2270-2289
9607
GAAUUGUUGCUAGGACAAC
11607
GAAuuGuuGcuAGGAcAAcdTsdT
sense


 


2270-2289
9608
GUUGUCCUAGCAACAAUUC
11608
GUUGUCCuAGcAAcAAUUCdTsdT
antis


 


1576-1595
9609
GCAGCAGCCUUCAGCUUUU
11609
GcAGcAGccuucAGcuuuudTsdT
sense


 


1576-1595
9610
AAAAGCUGAAGGCUGCUGC
11610
AAAAGCUGAAGGCUGCUGCdTsdT
antis


 


1577-1596
9611
CAGCAGCCUUCAGCUUUUG
11611
cAGcAGccuucAGcuuuuGdTsdT
sense


 


1577-1596
9612
CAAAAGCUGAAGGCUGCUG
11612
cAAAAGCUGAAGGCUGCUGdTsdT
antis


 


1623-1642
9613
AUGGCAGCAAGGUAACCAC
11613
AuGGcAGcAAGGuAAccAcdTsdT
sense


 


1623-1642
9614
GUGGUUACCUUGCUGCCAU
11614
GUGGUuACCUUGCUGCcAUdTsdT
antis


 


1645-1664
9615
AGUGGCAACUCCUGGCCAG
11615
AGuGGcAAcuccuGGccAGdTsdT
sense


 


1645-1664
9616
CUGGCCAGGAGUUGCCACU
11616
CUGGCcAGGAGUUGCcACUdTsdT
antis


 


1742-1761
9617
GCCAAACUUUGUGAUUCUG
11617
GccAAAcuuuGuGAuucuGdTsdT
sense


 


1742-1761
9618
CAGAAUCACAAAGUUUGGC
11618
cAGAAUcAcAAAGUUUGGCdTsdT
antis


 


1778-1797
9619
AAGAAAGUUCUACAGGACA
11619
AAGAAAGuucuAcAGGAcAdTsdT
sense


 


1778-1797
9620
UGUCCUGUAGAACUUUCUU
11620
UGUCCUGuAGAACUUUCUUdTsdT
antis


 


1920-1939
9621
UGGACUAUGUUCCGGAGAC
11621
uGGAcuAuGuuccGGAGAcdTsdT
sense


 


1920-1939
9622
GUCUCCGGAACAUAGUCCA
11622
GUCUCCGGAAcAuAGUCcAdTsdT
antis


 


1973-1992
9623
AAGCAGACACUCCCUGUGA
11623
AAGcAGAcAcucccuGuGAdTsdT
sense


 


1973-1992
9624
UCACAGGGAGUGUCUGCUU
11624
UcAcAGGGAGUGUCUGCUUdTsdT
antis


 


1984-2003
9625
CCCUGUGAUCUAUGUCAAG
11625
cccuGuGAucuAuGucAAGdTsdT
sense


 


1984-2003
9626
CUUGACAUAGAUCACAGGG
11626
CUUGAcAuAGAUcAcAGGGdTsdT
antis


 


2085-2104
9627
UCUUGUUGGAUCCUGAUAC
11627
ucuuGuuGGAuccuGAuAcdTsdT
sense


 


2085-2104
9628
GUAUCAGGAUCCAACAAGA
11628
GuAUcAGGAUCcAAcAAGAdTsdT
antis


 


2090-2109
9629
UUGGAUCCUGAUACAGCUG
11629
uuGGAuccuGAuAcAGcuGdTsdT
sense


 


2090-2109
9630
CAGCUGUAUCAGGAUCCAA
11630
cAGCUGuAUcAGGAUCcAAdTsdT
antis


 


2170-2189
9631
AUAUAUCUGUUCUCGGUAC
11631
AuAuAucuGuucucGGuAcdTsdT
sense


 


2170-2189
9632
GUACCGAGAACAGAUAUAU
11632
GuACCGAGAAcAGAuAuAUdTsdT
antis


 


2200-2219
9633
AGAGUUGAUCUUUGGAGCC
11633
AGAGuuGAucuuuGGAGccdTsdT
sense


 


2200-2219
9634
GGCUCCAAAGAUCAACUCU
11634
GGCUCcAAAGAUcAACUCUdTsdT
antis


 


2253-2272
9635
CAGGCUGUGUGUUGGCUGA
11635
cAGGcuGuGuGuuGGcuGAdTsdT
sense


 


2253-2272
9636
UCAGCCAACACACAGCCUG
11636
UcAGCcAAcAcAcAGCCUGdTsdT
antis


 


2264-2283
9637
UUGGCUGAAUUGUUGCUAG
11637
uuGGcuGAAuuGuuGcuAGdTsdT
sense


 


2264-2283
9638
CUAGCAACAAUUCAGCCAA
11638
CuAGcAAcAAUUcAGCcAAdTsdT
antis


 


2285-2304
9639
CAACCAAUAUUUCCUGGGG
11639
cAAccAAuAuuuccuGGGGdTsdT
sense


 


2285-2304
9640
CCCCAGGAAAUAUUGGUUG
11640
CCCcAGGAAAuAUUGGUUGdTsdT
antis


 


2315-2334
9641
GAUCAGUUGGUGGAAAUAA
11641
GAucAGuuGGuGGAAAuAAdTsdT
sense


 


2315-2334
9642
UUAUUUCCACCAACUGAUC
11642
UuAUUUCcACcAACUGAUCdTsdT
antis


 


2452-2471
9643
UCCACCAGAGGCAAUUGCA
11643
uccAccAGAGGcAAuuGcAdTsdT
sense


 


2452-2471
9644
UGCAAUUGCCUCUGGUGGA
11644
UGcAAUUGCCUCUGGUGGAdTsdT
antis


 


2503-2522
9645
CGCCCGGCUAACACCACUG
11645
cGcccGGcuAAcAccAcuGdTsdT
sense


 


2503-2522
9646
CAGUGGUGUUAGCCGGGCG
11646
cAGUGGUGUuAGCCGGGCGdTsdT
antis


 


2504-2523
9647
GCCCGGCUAACACCACUGG
11647
GcccGGcuAAcAccAcuGGdTsdT
sense


 


2504-2523
9648
CCAGUGGUGUUAGCCGGGC
11648
CcAGUGGUGUuAGCCGGGCdTsdT
antis


 


1961-1980
9649
UAUAGUCGAGCCAAGCAGA
11649
uAuAGucGAGccAAGcAGAdTsdT
sense


 


1961-1980
9650
UCUGCUUGGCUCGACUAUA
11650
UCUGCUUGGCUCGACuAuAdTsdT
antis


 


1699-1718
9651
CACGAAAGUGAUUGGAAAU
11651
cAcGAAAGuGAuuGGAAAudTsdT
sense


 


1699-1718
9652
AUUUCCAAUCACUUUCGUG
11652
AUUUCcAAUcACUUUCGUGdTsdT
antis


 


1791-1810
9653
AGGACAAGCGAUUUAAGAA
11653
AGGAcAAGcGAuuuAAGAAdTsdT
sense


 


1791-1810
9654
UUCUUAAAUCGCUUGUCCU
11654
UUCUuAAAUCGCUUGUCCUdTsdT
antis


 


1534-1553
9655
GCGACCGAGAACCACCUCC
11655
GcGAccGAGAAccAccuccdTsdT
sense


 


1534-1553
9656
GGAGGUGGUUCUCGGUCGC
11656
GGAGGUGGUUCUCGGUCGCdTsdT
antis


 


1899-1918
9657
AGGUCUACCUUAACCUGGU
11657
AGGucuAccuuAAccuGGudTsdT
sense


 


1899-1918
9658
ACCAGGUUAAGGUAGACCU
11658
ACcAGGUuAAGGuAGACCUdTsdT
antis


 


1931-1950
9659
CCGGAGACAGUGUACAGAG
11659
ccGGAGAcAGuGuAcAGAGdTsdT
sense


 


1931-1950
9660
CUCUGUACACUGUCUCCGG
11660
CUCUGuAcACUGUCUCCGGdTsdT
antis


 


1964-1983
9661
AGUCGAGCCAAGCAGACAC
11661
AGucGAGccAAGcAGAcAcdTsdT
sense


 


1964-1983
9662
GUGUCUGCUUGGCUCGACU
11662
GUGUCUGCUUGGCUCGACUdTsdT
antis


 


2056-2075
9663
CUGCCAUCGAGACAUUAAA
11663
cuGccAucGAGAcAuuAAAdTsdT
sense


 


2056-2075
9664
UUUAAUGUCUCGAUGGCAG
11664
UUuAAUGUCUCGAUGGcAGdTsdT
antis


 


2155-2174
9665
AGAGCCCAAUGUUUCAUAU
11665
AGAGcccAAuGuuucAuAudTsdT
sense


 


2155-2174
9666
AUAUGAAACAUUGGGCUCU
11666
AuAUGAAAcAUUGGGCUCUdTsdT
antis


 


2182-2201
9667
UCGGUACUACAGGGCACCA
11667
ucGGuAcuAcAGGGcAccAdTsdT
sense


 


2182-2201
9668
UGGUGCCCUGUAGUACCGA
11668
UGGUGCCCUGuAGuACCGAdTsdT
antis


 


2329-2348
9669
AAUAAUAAAGGUCCUAGGA
11669
AAuAAuAAAGGuccuAGGAdTsdT
sense


 


2329-2348
9670
UCCUAGGACCUUUAUUAUU
11670
UCCuAGGACCUUuAUuAUUdTsdT
antis


 


2360-2379
9671
GAGCAAAUUAGAGAAAUGA
11671
GAGcAAAuuAGAGAAAuGAdTsdT
sense


 


2360-2379
9672
UCAUUUCUCUAAUUUGCUC
11672
UcAUUUCUCuAAUUUGCUCdTsdT
antis


 


2500-2519
9673
UACCGCCCGGCUAACACCA
11673
uAccGcccGGcuAAcAccAdTsdT
sense


 


2500-2519
9674
UGGUGUUAGCCGGGCGGUA
11674
UGGUGUuAGCCGGGCGGuAdTsdT
antis


 


1526-1545
9675
AUGUCGGGGCGACCGAGAA
11675
AuGucGGGGcGAccGAGAAdTsdT
sense


 


1526-1545
9676
UUCUCGGUCGCCCCGACAU
11676
UUCUCGGUCGCCCCGAcAUdTsdT
antis


 


1535-1554
9677
CGACCGAGAACCACCUCCU
11677
cGAccGAGAAccAccuccudTsdT
sense


 


1535-1554
9678
AGGAGGUGGUUCUCGGUCG
11678
AGGAGGUGGUUCUCGGUCGdTsdT
antis


 


1553-1572
9679
UUUGCGGAGAGCUGCAAGC
11679
uuuGcGGAGAGcuGcAAGcdTsdT
sense


 


1553-1572
9680
GCUUGCAGCUCUCCGCAAA
11680
GCUUGcAGCUCUCCGcAAAdTsdT
antis


 


1628-1647
9681
AGCAAGGUAACCACAGUAG
11681
AGcAAGGuAAccAcAGuAGdTsdT
sense


 


1628-1647
9682
CUACUGUGGUUACCUUGCU
11682
CuACUGUGGUuACCUUGCUdTsdT
antis


 


1633-1652
9683
GGUAACCACAGUAGUGGCA
11683
GGuAAccAcAGuAGuGGcAdTsdT
sense


 


1633-1652
9684
UGCCACUACUGUGGUUACC
11684
UGCcACuACUGUGGUuACCdTsdT
antis


 


1682-1701
9685
GAAGUCAGUUAUACAGACA
11685
GAAGucAGuuAuAcAGAcAdTsdT
sense


 


1682-1701
9686
UGUCUGUAUAACUGACUUC
11686
UGUCUGuAuAACUGACUUCdTsdT
antis


 


1684-1703
9687
AGUCAGUUAUACAGACACG
11687
AGucAGuuAuAcAGAcAcGdTsdT
sense


 


1684-1703
9688
CGUGUCUGUAUAACUGACU
11688
CGUGUCUGuAuAACUGACUdTsdT
antis


 


1698-1717
9689
ACACGAAAGUGAUUGGAAA
11689
AcAcGAAAGuGAuuGGAAAdTsdT
sense


 


1698-1717
9690
UUUCCAAUCACUUUCGUGU
11690
UUUCcAAUcACUUUCGUGUdTsdT
antis


 


1700-1719
9691
ACGAAAGUGAUUGGAAAUG
11691
AcGAAAGuGAuuGGAAAuGdTsdT
sense


 


1700-1719
9692
CAUUUCCAAUCACUUUCGU
11692
cAUUUCcAAUcACUUUCGUdTsdT
antis


 


1703-1722
9693
AAAGUGAUUGGAAAUGGAU
11693
AAAGuGAuuGGAAAuGGAudTsdT
sense


 


1703-1722
9694
AUCCAUUUCCAAUCACUUU
11694
AUCcAUUUCcAAUcACUUUdTsdT
antis


 


1735-1754
9695
AUAUCAAGCCAAACUUUGU
11695
AuAucAAGccAAAcuuuGudTsdT
sense


 


1735-1754
9696
ACAAAGUUUGGCUUGAUAU
11696
AcAAAGUUUGGCUUGAuAUdTsdT
antis


 


1741-1760
9697
AGCCAAACUUUGUGAUUCU
11697
AGccAAAcuuuGuGAuucudTsdT
sense


 


1741-1760
9698
AGAAUCACAAAGUUUGGCU
11698
AGAAUcAcAAAGUUUGGCUdTsdT
antis


 


1773-1792
9699
CCAUCAAGAAAGUUCUACA
11699
ccAucAAGAAAGuucuAcAdTsdT
sense


 


1773-1792
9700
UGUAGAACUUUCUUGAUGG
11700
UGuAGAACUUUCUUGAUGGdTsdT
antis


 


1774-1793
9701
CAUCAAGAAAGUUCUACAG
11701
cAucAAGAAAGuucuAcAGdTsdT
sense


 


1774-1793
9702
CUGUAGAACUUUCUUGAUG
11702
CUGuAGAACUUUCUUGAUGdTsdT
antis


 


1784-1803
9703
GUUCUACAGGACAAGCGAU
11703
GuucuAcAGGAcAAGcGAudTsdT
sense


 


1784-1803
9704
AUCGCUUGUCCUGUAGAAC
11704
AUCGCUUGUCCUGuAGAACdTsdT
antis


 


1823-1842
9705
AUCAUGAGAAAGCUAGACC
11705
AucAuGAGAAAGcuAGAccdTsdT
sense


 


1823-1842
9706
GGUCUAGCUUUCUCAUGAU
11706
GGUCuAGCUUUCUcAUGAUdTsdT
antis


 


1868-1887
9707
UUCUUCUACUCGAGUGGUG
11707
uucuucuAcucGAGuGGuGdTsdT
sense


 


1868-1887
9708
CACCACUCGAGUAGAAGAA
11708
cACcACUCGAGuAGAAGAAdTsdT
antis


 


1876-1895
9709
CUCGAGUGGUGAGAAGAAA
11709
cucGAGuGGuGAGAAGAAAdTsdT
sense


 


1876-1895
9710
UUUCUUCUCACCACUCGAG
11710
UUUCUUCUcACcACUCGAGdTsdT
antis


 


1907-1926
9711
CUUAACCUGGUGCUGGACU
11711
cuuAAccuGGuGcuGGAcudTsdT
sense


 


1907-1926
9712
AGUCCAGCACCAGGUUAAG
11712
AGUCcAGcACcAGGUuAAGdTsdT
antis


 


1910-1929
9713
AACCUGGUGCUGGACUAUG
11713
AAccuGGuGcuGGAcuAuGdTsdT
sense


 


1910-1929
9714
CAUAGUCCAGCACCAGGUU
11714
cAuAGUCcAGcACcAGGUUdTsdT
antis


 


1930-1949
9715
UCCGGAGACAGUGUACAGA
11715
uccGGAGAcAGuGuAcAGAdTsdT
sense


 


1930-1949
9716
UCUGUACACUGUCUCCGGA
11716
UCUGuAcACUGUCUCCGGAdTsdT
antis


 


1939-1958
9717
AGUGUACAGAGUCGCCAGA
11717
AGuGuAcAGAGucGccAGAdTsdT
sense


 


1939-1958
9718
UCUGGCGACUCUGUACACU
11718
UCUGGCGACUCUGuAcACUdTsdT
antis


 


1940-1959
9719
GUGUACAGAGUCGCCAGAC
11719
GuGuAcAGAGucGccAGAcdTsdT
sense


 


1940-1959
9720
GUCUGGCGACUCUGUACAC
11720
GUCUGGCGACUCUGuAcACdTsdT
antis


 


1943-1962
9721
UACAGAGUCGCCAGACACU
11721
uAcAGAGucGccAGAcAcudTsdT
sense


 


1943-1962
9722
AGUGUCUGGCGACUCUGUA
11722
AGUGUCUGGCGACUCUGuAdTsdT
antis


 


1946-1965
9723
AGAGUCGCCAGACACUAUA
11723
AGAGucGccAGAcAcuAuAdTsdT
sense


 


1946-1965
9724
UAUAGUGUCUGGCGACUCU
11724
uAuAGUGUCUGGCGACUCUdTsdT
antis


 


1948-1967
9725
AGUCGCCAGACACUAUAGU
11725
AGucGccAGAcAcuAuAGudTsdT
sense


 


1948-1967
9726
ACUAUAGUGUCUGGCGACU
11726
ACuAuAGUGUCUGGCGACUdTsdT
antis


 


1963-1982
9727
UAGUCGAGCCAAGCAGACA
11727
uAGucGAGccAAGcAGAcAdTsdT
sense


 


1963-1982
9728
UGUCUGCUUGGCUCGACUA
11728
UGUCUGCUUGGCUCGACuAdTsdT
antis


 


1987-2006
9729
UGUGAUCUAUGUCAAGUUG
11729
uGuGAucuAuGucAAGuuGdTsdT
sense


 


1987-2006
9730
CAACUUGACAUAGAUCACA
11730
cAACUUGAcAuAGAUcAcAdTsdT
antis


 


1991-2010
9731
AUCUAUGUCAAGUUGUAUA
11731
AucuAuGucAAGuuGuAuAdTsdT
sense


 


1991-2010
9732
UAUACAACUUGACAUAGAU
11732
uAuAcAACUUGAcAuAGAUdTsdT
antis


 


1992-2011
9733
UCUAUGUCAAGUUGUAUAU
11733
ucuAuGucAAGuuGuAuAudTsdT
sense


 


1992-2011
9734
AUAUACAACUUGACAUAGA
11734
AuAuAcAACUUGAcAuAGAdTsdT
antis


 


2000-2019
9735
AAGUUGUAUAUGUAUCAGC
11735
AAGuuGuAuAuGuAucAGcdTsdT
sense


 


2000-2019
9736
GCUGAUACAUAUACAACUU
11736
GCUGAuAcAuAuAcAACUUdTsdT
antis


 


2001-2020
9737
AGUUGUAUAUGUAUCAGCU
11737
AGuuGuAuAuGuAucAGcudTsdT
sense


 


2001-2020
9738
AGCUGAUACAUAUACAACU
11738
AGCUGAuAcAuAuAcAACUdTsdT
antis


 


2004-2023
9739
UGUAUAUGUAUCAGCUGUU
11739
uGuAuAuGuAucAGcuGuudTsdT
sense


 


2004-2023
9740
AACAGCUGAUACAUAUACA
11740
AAcAGCUGAuAcAuAuAcAdTsdT
antis


 


2007-2026
9741
AUAUGUAUCAGCUGUUCAG
11741
AuAuGuAucAGcuGuucAGdTsdT
sense


 


2007-2026
9742
CUGAACAGCUGAUACAUAU
11742
CUGAAcAGCUGAuAcAuAUdTsdT
antis


 


2048-2067
9743
UUUGGAAUCUGCCAUCGAG
11743
uuuGGAAucuGccAucGAGdTsdT
sense


 


2048-2067
9744
CUCGAUGGCAGAUUCCAAA
11744
CUCGAUGGcAGAUUCcAAAdTsdT
antis


 


2100-2119
9745
AUACAGCUGUAUUAAAACU
11745
AuAcAGcuGuAuuAAAAcudTsdT
sense


 


2100-2119
9746
AGUUUUAAUACAGCUGUAU
11746
AGUUUuAAuAcAGCUGuAUdTsdT
antis


 


2107-2126
9747
UGUAUUAAAACUCUGUGAC
11747
uGuAuuAAAAcucuGuGAcdTsdT
sense


 


2107-2126
9748
GUCACAGAGUUUUAAUACA
11748
GUcAcAGAGUUUuAAuAcAdTsdT
antis


 


2151-2170
9749
GAGGAGAGCCCAAUGUUUC
11749
GAGGAGAGcccAAuGuuucdTsdT
sense


 


2151-2170
9750
GAAACAUUGGGCUCUCCUC
11750
GAAAcAUUGGGCUCUCCUCdTsdT
antis


 


2158-2177
9751
GCCCAAUGUUUCAUAUAUC
11751
GcccAAuGuuucAuAuAucdTsdT
sense


 


2158-2177
9752
GAUAUAUGAAACAUUGGGC
11752
GAuAuAUGAAAcAUUGGGCdTsdT
antis


 


2166-2185
9753
UUUCAUAUAUCUGUUCUCG
11753
uuucAuAuAucuGuucucGdTsdT
sense


 


2166-2185
9754
CGAGAACAGAUAUAUGAAA
11754
CGAGAAcAGAuAuAUGAAAdTsdT
antis


 


2172-2191
9755
AUAUCUGUUCUCGGUACUA
11755
AuAucuGuucucGGuAcuAdTsdT
sense


 


2172-2191
9756
UAGUACCGAGAACAGAUAU
11756
uAGuACCGAGAAcAGAuAUdTsdT
antis


 


2183-2202
9757
CGGUACUACAGGGCACCAG
11757
cGGuAcuAcAGGGcAccAGdTsdT
sense


 


2183-2202
9758
CUGGUGCCCUGUAGUACCG
11758
CUGGUGCCCUGuAGuACCGdTsdT
antis


 


2232-2251
9759
CCAGUAUAGAUGUAUGGUC
11759
ccAGuAuAGAuGuAuGGucdTsdT
sense


 


2232-2251
9760
GACCAUACAUCUAUACUGG
11760
GACcAuAcAUCuAuACUGGdTsdT
antis


 


2273-2292
9761
UUGUUGCUAGGACAACCAA
11761
uuGuuGcuAGGAcAAccAAdTsdT
sense


 


2273-2292
9762
UUGGUUGUCCUAGCAACAA
11762
UUGGUUGUCCuAGcAAcAAdTsdT
antis


 


2274-2293
9763
UGUUGCUAGGACAACCAAU
11763
uGuuGcuAGGAcAAccAAudTsdT
sense


 


2274-2293
9764
AUUGGUUGUCCUAGCAACA
11764
AUUGGUUGUCCuAGcAAcAdTsdT
antis


 


2318-2337
9765
CAGUUGGUGGAAAUAAUAA
11765
cAGuuGGuGGAAAuAAuAAdTsdT
sense


 


2318-2337
9766
UUAUUAUUUCCACCAACUG
11766
UuAUuAUUUCcACcAACUGdTsdT
antis


 


2361-2380
9767
AGCAAAUUAGAGAAAUGAA
11767
AGcAAAuuAGAGAAAuGAAdTsdT
sense


 


2361-2380
9768
UUCAUUUCUCUAAUUUGCU
11768
UUcAUUUCUCuAAUUUGCUdTsdT
antis


 


2380-2399
9769
CCCAAAUUAUACAGAAUUC
11769
cccAAAuuAuAcAGAAuucdTsdT
sense


 


2380-2399
9770
GAAUUCUGUAUAAUUUGGG
11770
GAAUUCUGuAuAAUUUGGGdTsdT
antis


 


2400-2419
9771
AAUUCCCUCAAAUCAAGGC
11771
AAuucccucAAAucAAGGcdTsdT
sense


 


2400-2419
9772
GCCUUGAUUUGAGGGAAUU
11772
GCCUUGAUUUGAGGGAAUUdTsdT
antis


 


2409-2428
9773
AAAUCAAGGCACAUCCUUG
11773
AAAucAAGGcAcAuccuuGdTsdT
sense


 


2409-2428
9774
CAAGGAUGUGCCUUGAUUU
11774
cAAGGAUGUGCCUUGAUUUdTsdT
antis


 


2445-2464
9775
CCCGAACUCCACCAGAGGC
11775
cccGAAcuccAccAGAGGcdTsdT
sense


 


2445-2464
9776
GCCUCUGGUGGAGUUCGGG
11776
GCCUCUGGUGGAGUUCGGGdTsdT
antis


 


2479-2498
9777
CCGUCUGCUGGAGUACACA
11777
ccGucuGcuGGAGuAcAcAdTsdT
sense


 


2479-2498
9778
UGUGUACUCCAGCAGACGG
11778
UGUGuACUCcAGcAGACGGdTsdT
antis


 


2489-2508
9779
GAGUACACACCUACCGCCC
11779
GAGuAcAcAccuAccGcccdTsdT
sense


 


2489-2508
9780
GGGCGGUAGGUGUGUACUC
11780
GGGCGGuAGGUGUGuACUCdTsdT
antis


 


1819-1838
9781
CCAGAUCAUGAGAAAGCUA
11781
ccAGAucAuGAGAAAGcuAdTsdT
sense


 


1819-1838
9782
UAGCUUUCUCAUGAUCUGG
11782
uAGCUUUCUcAUGAUCUGGdTsdT
antis


 


2030-2049
9783
CUAGCCUAUAUCCAUUCCU
11783
cuAGccuAuAuccAuuccudTsdT
sense


 


2030-2049
9784
AGGAAUGGAUAUAGGCUAG
11784
AGGAAUGGAuAuAGGCuAGdTsdT
antis


 


2154-2173
9785
GAGAGCCCAAUGUUUCAUA
11785
GAGAGcccAAuGuuucAuAdTsdT
sense


 


2154-2173
9786
UAUGAAACAUUGGGCUCUC
11786
uAUGAAAcAUUGGGCUCUCdTsdT
antis


 


2184-2203
9787
GGUACUACAGGGCACCAGA
11787
GGuAcuAcAGGGcAccAGAdTsdT
sense


 


2184-2203
9788
UCUGGUGCCCUGUAGUACC
11788
UCUGGUGCCCUGuAGuACCdTsdT
antis


 


2190-2209
9789
ACAGGGCACCAGAGUUGAU
11789
AcAGGGcAccAGAGuuGAudTsdT
sense


 


2190-2209
9790
AUCAACUCUGGUGCCCUGU
11790
AUcAACUCUGGUGCCCUGUdTsdT
antis


 


2314-2333
9791
GGAUCAGUUGGUGGAAAUA
11791
GGAucAGuuGGuGGAAAuAdTsdT
sense


 


2314-2333
9792
UAUUUCCACCAACUGAUCC
11792
uAUUUCcACcAACUGAUCCdTsdT
antis


 


2428-2447
9793
GACAAAGGUCUUCCGGCCC
11793
GAcAAAGGucuuccGGcccdTsdT
sense


 


2428-2447
9794
GGGCCGGAAGACCUUUGUC
11794
GGGCCGGAAGACCUUUGUCdTsdT
antis


 


1913-1932
9795
CUGGUGCUGGACUAUGUUC
11795
cuGGuGcuGGAcuAuGuucdTsdT
sense


 


1913-1932
9796
GAACAUAGUCCAGCACCAG
11796
GAAcAuAGUCcAGcACcAGdTsdT
antis


 


1530-1549
9797
CGGGGCGACCGAGAACCAC
11797
cGGGGcGAccGAGAAccAcdTsdT
sense


 


1530-1549
9798
GUGGUUCUCGGUCGCCCCG
11798
GUGGUUCUCGGUCGCCCCGdTsdT
antis


 


1549-1568
9799
CUCCUUUGCGGAGAGCUGC
11799
cuccuuuGcGGAGAGcuGcdTsdT
sense


 


1549-1568
9800
GCAGCUCUCCGCAAAGGAG
11800
GcAGCUCUCCGcAAAGGAGdTsdT
antis


 


1550-1569
9801
UCCUUUGCGGAGAGCUGCA
11801
uccuuuGcGGAGAGcuGcAdTsdT
sense


 


1550-1569
9802
UGCAGCUCUCCGCAAAGGA
11802
UGcAGCUCUCCGcAAAGGAdTsdT
antis


 


1610-1629
9803
AGCAGAGAUAAAGAUGGCA
11803
AGcAGAGAuAAAGAuGGcAdTsdT
sense


 


1610-1629
9804
UGCCAUCUUUAUCUCUGCU
11804
UGCcAUCUUuAUCUCUGCUdTsdT
antis


 


1642-1661
9805
AGUAGUGGCAACUCCUGGC
11805
AGuAGuGGcAAcuccuGGcdTsdT
sense


 


1642-1661
9806
GCCAGGAGUUGCCACUACU
11806
GCcAGGAGUUGCcACuACUdTsdT
antis


 


1643-1662
9807
GUAGUGGCAACUCCUGGCC
11807
GuAGuGGcAAcuccuGGccdTsdT
sense


 


1643-1662
9808
GGCCAGGAGUUGCCACUAC
11808
GGCcAGGAGUUGCcACuACdTsdT
antis


 


1696-1715
9809
AGACACGAAAGUGAUUGGA
11809
AGAcAcGAAAGuGAuuGGAdTsdT
sense


 


1696-1715
9810
UCCAAUCACUUUCGUGUCU
11810
UCcAAUcACUUUCGUGUCUdTsdT
antis


 


1704-1723
9811
AAGUGAUUGGAAAUGGAUC
11811
AAGuGAuuGGAAAuGGAucdTsdT
sense


 


1704-1723
9812
GAUCCAUUUCCAAUCACUU
11812
GAUCcAUUUCcAAUcACUUdTsdT
antis


 


1719-1738
9813
GAUCAUUUGGUGUGGUAUA
11813
GAucAuuuGGuGuGGuAuAdTsdT
sense


 


1719-1738
9814
UAUACCACACCAAAUGAUC
11814
uAuACcAcACcAAAUGAUCdTsdT
antis


 


1728-1747
9815
GUGUGGUAUAUCAAGCCAA
11815
GuGuGGuAuAucAAGccAAdTsdT
sense


 


1728-1747
9816
UUGGCUUGAUAUACCACAC
11816
UUGGCUUGAuAuACcAcACdTsdT
antis


 


1731-1750
9817
UGGUAUAUCAAGCCAAACU
11817
uGGuAuAucAAGccAAAcudTsdT
sense


 


1731-1750
9818
AGUUUGGCUUGAUAUACCA
11818
AGUUUGGCUUGAuAuACcAdTsdT
antis


 


1732-1751
9819
GGUAUAUCAAGCCAAACUU
11819
GGuAuAucAAGccAAAcuudTsdT
sense


 


1732-1751
9820
AAGUUUGGCUUGAUAUACC
11820
AAGUUUGGCUUGAuAuACCdTsdT
antis


 


1733-1752
9821
GUAUAUCAAGCCAAACUUU
11821
GuAuAucAAGccAAAcuuudTsdT
sense


 


1733-1752
9822
AAAGUUUGGCUUGAUAUAC
11822
AAAGUUUGGCUUGAuAuACdTsdT
antis


 


1768-1787
9823
GGUUGCCAUCAAGAAAGUU
11823
GGuuGccAucAAGAAAGuudTsdT
sense


 


1768-1787
9824
AACUUUCUUGAUGGCAACC
11824
AACUUUCUUGAUGGcAACCdTsdT
antis


 


1800-1819
9825
GAUUUAAGAACCGAGAGCU
11825
GAuuuAAGAAccGAGAGcudTsdT
sense


 


1800-1819
9826
AGCUCUCGGUUCUUAAAUC
11826
AGCUCUCGGUUCUuAAAUCdTsdT
antis


 


1802-1821
9827
UUUAAGAACCGAGAGCUCC
11827
uuuAAGAAccGAGAGcuccdTsdT
sense


 


1802-1821
9828
GGAGCUCUCGGUUCUUAAA
11828
GGAGCUCUCGGUUCUuAAAdTsdT
antis


 


1821-1840
9829
AGAUCAUGAGAAAGCUAGA
11829
AGAucAuGAGAAAGcuAGAdTsdT
sense


 


1821-1840
9830
UCUAGCUUUCUCAUGAUCU
11830
UCuAGCUUUCUcAUGAUCUdTsdT
antis


 


1830-1849
9831
GAAAGCUAGACCACUGUAA
11831
GAAAGcuAGAccAcuGuAAdTsdT
sense


 


1830-1849
9832
UUACAGUGGUCUAGCUUUC
11832
UuAcAGUGGUCuAGCUUUCdTsdT
antis


 


1831-1850
9833
AAAGCUAGACCACUGUAAC
11833
AAAGcuAGAccAcuGuAAcdTsdT
sense


 


1831-1850
9834
GUUACAGUGGUCUAGCUUU
11834
GUuAcAGUGGUCuAGCUUUdTsdT
antis


 


1856-1875
9835
CGACUGCGGUAUUUCUUCU
11835
cGAcuGcGGuAuuucuucudTsdT
sense


 


1856-1875
9836
AGAAGAAAUACCGCAGUCG
11836
AGAAGAAAuACCGcAGUCGdTsdT
antis


 


1857-1876
9837
GACUGCGGUAUUUCUUCUA
11837
GAcuGcGGuAuuucuucuAdTsdT
sense


 


1857-1876
9838
UAGAAGAAAUACCGCAGUC
11838
uAGAAGAAAuACCGcAGUCdTsdT
antis


 


1875-1894
9839
ACUCGAGUGGUGAGAAGAA
11839
AcucGAGuGGuGAGAAGAAdTsdT
sense


 


1875-1894
9840
UUCUUCUCACCACUCGAGU
11840
UUCUUCUcACcACUCGAGUdTsdT
antis


 


1877-1896
9841
UCGAGUGGUGAGAAGAAAG
11841
ucGAGuGGuGAGAAGAAAGdTsdT
sense


 


1877-1896
9842
CUUUCUUCUCACCACUCGA
11842
CUUUCUUCUcACcACUCGAdTsdT
antis


 


1897-1916
9843
UGAGGUCUACCUUAACCUG
11843
uGAGGucuAccuuAAccuGdTsdT
sense


 


1897-1916
9844
CAGGUUAAGGUAGACCUCA
11844
cAGGUuAAGGuAGACCUcAdTsdT
antis


 


1908-1927
9845
UUAACCUGGUGCUGGACUA
11845
uuAAccuGGuGcuGGAcuAdTsdT
sense


 


1908-1927
9846
UAGUCCAGCACCAGGUUAA
11846
uAGUCcAGcACcAGGUuAAdTsdT
antis


 


1923-1942
9847
ACUAUGUUCCGGAGACAGU
11847
AcuAuGuuccGGAGAcAGudTsdT
sense


 


1923-1942
9848
ACUGUCUCCGGAACAUAGU
11848
ACUGUCUCCGGAAcAuAGUdTsdT
antis


 


1928-1947
9849
GUUCCGGAGACAGUGUACA
11849
GuuccGGAGAcAGuGuAcAdTsdT
sense


 


1928-1947
9850
UGUACACUGUCUCCGGAAC
11850
UGuAcACUGUCUCCGGAACdTsdT
antis


 


1934-1953
9851
GAGACAGUGUACAGAGUCG
11851
GAGAcAGuGuAcAGAGucGdTsdT
sense


 


1934-1953
9852
CGACUCUGUACACUGUCUC
11852
CGACUCUGuAcACUGUCUCdTsdT
antis


 


1951-1970
9853
CGCCAGACACUAUAGUCGA
11853
cGccAGAcAcuAuAGucGAdTsdT
sense


 


1951-1970
9854
UCGACUAUAGUGUCUGGCG
11854
UCGACuAuAGUGUCUGGCGdTsdT
antis


 


1981-2000
9855
ACUCCCUGUGAUCUAUGUC
11855
AcucccuGuGAucuAuGucdTsdT
sense


 


1981-2000
9856
GACAUAGAUCACAGGGAGU
11856
GAcAuAGAUcAcAGGGAGUdTsdT
antis


 


1983-2002
9857
UCCCUGUGAUCUAUGUCAA
11857
ucccuGuGAucuAuGucAAdTsdT
sense


 


1983-2002
9858
UUGACAUAGAUCACAGGGA
11858
UUGAcAuAGAUcAcAGGGAdTsdT
antis


 


1994-2013
9859
UAUGUCAAGUUGUAUAUGU
11859
uAuGucAAGuuGuAuAuGudTsdT
sense


 


1994-2013
9860
ACAUAUACAACUUGACAUA
11860
AcAuAuAcAACUUGAcAuAdTsdT
antis


 


2003-2022
9861
UUGUAUAUGUAUCAGCUGU
11861
uuGuAuAuGuAucAGcuGudTsdT
sense


 


2003-2022
9862
ACAGCUGAUACAUAUACAA
11862
AcAGCUGAuAcAuAuAcAAdTsdT
antis


 


2067-2086
9863
ACAUUAAACCACAGAACCU
11863
AcAuuAAAccAcAGAAccudTsdT
sense


 


2067-2086
9864
AGGUUCUGUGGUUUAAUGU
11864
AGGUUCUGUGGUUuAAUGUdTsdT
antis


 


2077-2096
9865
ACAGAACCUCUUGUUGGAU
11865
AcAGAAccucuuGuuGGAudTsdT
sense


 


2077-2096
9866
AUCCAACAAGAGGUUCUGU
11866
AUCcAAcAAGAGGUUCUGUdTsdT
antis


 


2079-2098
9867
AGAACCUCUUGUUGGAUCC
11867
AGAAccucuuGuuGGAuccdTsdT
sense


 


2079-2098
9868
GGAUCCAACAAGAGGUUCU
11868
GGAUCcAAcAAGAGGUUCUdTsdT
antis


 


2087-2106
9869
UUGUUGGAUCCUGAUACAG
11869
uuGuuGGAuccuGAuAcAGdTsdT
sense


 


2087-2106
9870
CUGUAUCAGGAUCCAACAA
11870
CUGuAUcAGGAUCcAAcAAdTsdT
antis


 


2093-2112
9871
GAUCCUGAUACAGCUGUAU
11871
GAuccuGAuAcAGcuGuAudTsdT
sense


 


2093-2112
9872
AUACAGCUGUAUCAGGAUC
11872
AuAcAGCUGuAUcAGGAUCdTsdT
antis


 


2099-2118
9873
GAUACAGCUGUAUUAAAAC
11873
GAuAcAGcuGuAuuAAAAcdTsdT
sense


 


2099-2118
9874
GUUUUAAUACAGCUGUAUC
11874
GUUUuAAuAcAGCUGuAUCdTsdT
antis


 


2135-2154
9875
GCAAAGCAGCUGGUCCGAG
11875
GcAAAGcAGcuGGuccGAGdTsdT
sense


 


2135-2154
9876
CUCGGACCAGCUGCUUUGC
11876
CUCGGACcAGCUGCUUUGCdTsdT
antis


 


2150-2169
9877
CGAGGAGAGCCCAAUGUUU
11877
cGAGGAGAGcccAAuGuuudTsdT
sense


 


2150-2169
9878
AAACAUUGGGCUCUCCUCG
11878
AAAcAUUGGGCUCUCCUCGdTsdT
antis


 


2157-2176
9879
AGCCCAAUGUUUCAUAUAU
11879
AGcccAAuGuuucAuAuAudTsdT
sense


 


2157-2176
9880
AUAUAUGAAACAUUGGGCU
11880
AuAuAUGAAAcAUUGGGCUdTsdT
antis


 


2198-2217
9881
CCAGAGUUGAUCUUUGGAG
11881
ccAGAGuuGAucuuuGGAGdTsdT
sense


 


2198-2217
9882
CUCCAAAGAUCAACUCUGG
11882
CUCcAAAGAUcAACUCUGGdTsdT
antis


 


2199-2218
9883
CAGAGUUGAUCUUUGGAGC
11883
cAGAGuuGAucuuuGGAGcdTsdT
sense


 


2199-2218
9884
GCUCCAAAGAUCAACUCUG
11884
GCUCcAAAGAUcAACUCUGdTsdT
antis


 


2216-2235
9885
GCCACUGAUUACACGUCCA
11885
GccAcuGAuuAcAcGuccAdTsdT
sense


 


2216-2235
9886
UGGACGUGUAAUCAGUGGC
11886
UGGACGUGuAAUcAGUGGCdTsdT
antis


 


2237-2256
9887
AUAGAUGUAUGGUCUGCAG
11887
AuAGAuGuAuGGucuGcAGdTsdT
sense


 


2237-2256
9888
CUGCAGACCAUACAUCUAU
11888
CUGcAGACcAuAcAUCuAUdTsdT
antis


 


2243-2262
9889
GUAUGGUCUGCAGGCUGUG
11889
GuAuGGucuGcAGGcuGuGdTsdT
sense


 


2243-2262
9890
CACAGCCUGCAGACCAUAC
11890
cAcAGCCUGcAGACcAuACdTsdT
antis


 


2272-2291
9891
AUUGUUGCUAGGACAACCA
11891
AuuGuuGcuAGGAcAAccAdTsdT
sense


 


2272-2291
9892
UGGUUGUCCUAGCAACAAU
11892
UGGUUGUCCuAGcAAcAAUdTsdT
antis


 


2283-2302
9893
GACAACCAAUAUUUCCUGG
11893
GAcAAccAAuAuuuccuGGdTsdT
sense


 


2283-2302
9894
CCAGGAAAUAUUGGUUGUC
11894
CcAGGAAAuAUUGGUUGUCdTsdT
antis


 


2291-2310
9895
AUAUUUCCUGGGGACAGUG
11895
AuAuuuccuGGGGAcAGuGdTsdT
sense


 


2291-2310
9896
CACUGUCCCCAGGAAAUAU
11896
cACUGUCCCcAGGAAAuAUdTsdT
antis


 


2311-2330
9897
UGUGGAUCAGUUGGUGGAA
11897
uGuGGAucAGuuGGuGGAAdTsdT
sense


 


2311-2330
9898
UUCCACCAACUGAUCCACA
11898
UUCcACcAACUGAUCcAcAdTsdT
antis


 


2353-2372
9899
AACAAGGGAGCAAAUUAGA
11899
AAcAAGGGAGcAAAuuAGAdTsdT
sense


 


2353-2372
9900
UCUAAUUUGCUCCCUUGUU
11900
UCuAAUUUGCUCCCUUGUUdTsdT
antis


 


2359-2378
9901
GGAGCAAAUUAGAGAAAUG
11901
GGAGcAAAuuAGAGAAAuGdTsdT
sense


 


2359-2378
9902
CAUUUCUCUAAUUUGCUCC
11902
cAUUUCUCuAAUUUGCUCCdTsdT
antis


 


2379-2398
9903
ACCCAAAUUAUACAGAAUU
11903
AcccAAAuuAuAcAGAAuudTsdT
sense


 


2379-2398
9904
AAUUCUGUAUAAUUUGGGU
11904
AAUUCUGuAuAAUUUGGGUdTsdT
antis


 


2408-2427
9905
CAAAUCAAGGCACAUCCUU
11905
cAAAucAAGGcAcAuccuudTsdT
sense


 


2408-2427
9906
AAGGAUGUGCCUUGAUUUG
11906
AAGGAUGUGCCUUGAUUUGdTsdT
antis


 


2412-2431
9907
UCAAGGCACAUCCUUGGAC
11907
ucAAGGcAcAuccuuGGAcdTsdT
sense


 


2412-2431
9908
GUCCAAGGAUGUGCCUUGA
11908
GUCcAAGGAUGUGCCUUGAdTsdT
antis


 


2438-2457
9909
UUCCGGCCCCGAACUCCAC
11909
uuccGGccccGAAcuccAcdTsdT
sense


 


2438-2457
9910
GUGGAGUUCGGGGCCGGAA
11910
GUGGAGUUCGGGGCCGGAAdTsdT
antis


 


2476-2495
9911
CAGCCGUCUGCUGGAGUAC
11911
cAGccGucuGcuGGAGuAcdTsdT
sense


 


2476-2495
9912
GUACUCCAGCAGACGGCUG
11912
GuACUCcAGcAGACGGCUGdTsdT
antis


 


2477-2496
9913
AGCCGUCUGCUGGAGUACA
11913
AGccGucuGcuGGAGuAcAdTsdT
sense


 


2477-2496
9914
UGUACUCCAGCAGACGGCU
11914
UGuACUCcAGcAGACGGCUdTsdT
antis


 


2478-2497
9915
GCCGUCUGCUGGAGUACAC
11915
GccGucuGcuGGAGuAcAcdTsdT
sense


 


2478-2497
9916
GUGUACUCCAGCAGACGGC
11916
GUGuACUCcAGcAGACGGCdTsdT
antis


 


2484-2503
9917
UGCUGGAGUACACACCUAC
11917
uGcuGGAGuAcAcAccuAcdTsdT
sense


 


2484-2503
9918
GUAGGUGUGUACUCCAGCA
11918
GuAGGUGUGuACUCcAGcAdTsdT
antis


 


1527-1546
9919
UGUCGGGGCGACCGAGAAC
11919
uGucGGGGcGAccGAGAAcdTsdT
sense


 


1527-1546
9920
GUUCUCGGUCGCCCCGACA
11920
GUUCUCGGUCGCCCCGAcAdTsdT
antis


 


1531-1550
9921
GGGGCGACCGAGAACCACC
11921
GGGGcGAccGAGAAccAccdTsdT
sense


 


1531-1550
9922
GGUGGUUCUCGGUCGCCCC
11922
GGUGGUUCUCGGUCGCCCCdTsdT
antis


 


1536-1555
9923
GACCGAGAACCACCUCCUU
11923
GAccGAGAAccAccuccuudTsdT
sense


 


1536-1555
9924
AAGGAGGUGGUUCUCGGUC
11924
AAGGAGGUGGUUCUCGGUCdTsdT
antis


 


1542-1561
9925
GAACCACCUCCUUUGCGGA
11925
GAAccAccuccuuuGcGGAdTsdT
sense


 


1542-1561
9926
UCCGCAAAGGAGGUGGUUC
11926
UCCGcAAAGGAGGUGGUUCdTsdT
antis


 


1552-1571
9927
CUUUGCGGAGAGCUGCAAG
11927
cuuuGcGGAGAGcuGcAAGdTsdT
sense


 


1552-1571
9928
CUUGCAGCUCUCCGCAAAG
11928
CUUGcAGCUCUCCGcAAAGdTsdT
antis


 


1556-1575
9929
GCGGAGAGCUGCAAGCCAG
11929
GcGGAGAGcuGcAAGccAGdTsdT
sense


 


1556-1575
9930
CUGGCUUGCAGCUCUCCGC
11930
CUGGCUUGcAGCUCUCCGCdTsdT
antis


 


1564-1583
9931
CUGCAAGCCAGUGCAGCAG
11931
cuGcAAGccAGuGcAGcAGdTsdT
sense


 


1564-1583
9932
CUGCUGCACUGGCUUGCAG
11932
CUGCUGcACUGGCUUGcAGdTsdT
antis


 


1572-1591
9933
CAGUGCAGCAGCCUUCAGC
11933
cAGuGcAGcAGccuucAGcdTsdT
sense


 


1572-1591
9934
GCUGAAGGCUGCUGCACUG
11934
GCUGAAGGCUGCUGcACUGdTsdT
antis


 


1578-1597
9935
AGCAGCCUUCAGCUUUUGG
11935
AGcAGccuucAGcuuuuGGdTsdT
sense


 


1578-1597
9936
CCAAAAGCUGAAGGCUGCU
11936
CcAAAAGCUGAAGGCUGCUdTsdT
antis


 


1579-1598
9937
GCAGCCUUCAGCUUUUGGU
11937
GcAGccuucAGcuuuuGGudTsdT
sense


 


1579-1598
9938
ACCAAAAGCUGAAGGCUGC
11938
ACcAAAAGCUGAAGGCUGCdTsdT
antis


 


1581-1600
9939
AGCCUUCAGCUUUUGGUAG
11939
AGccuucAGcuuuuGGuAGdTsdT
sense


 


1581-1600
9940
CUACCAAAAGCUGAAGGCU
11940
CuACcAAAAGCUGAAGGCUdTsdT
antis


 


1582-1601
9941
GCCUUCAGCUUUUGGUAGC
11941
GccuucAGcuuuuGGuAGcdTsdT
sense


 


1582-1601
9942
GCUACCAAAAGCUGAAGGC
11942
GCuACcAAAAGCUGAAGGCdTsdT
antis


 


1585-1604
9943
UUCAGCUUUUGGUAGCAUG
11943
uucAGcuuuuGGuAGcAuGdTsdT
sense


 


1585-1604
9944
CAUGCUACCAAAAGCUGAA
11944
cAUGCuACcAAAAGCUGAAdTsdT
antis


 


1587-1606
9945
CAGCUUUUGGUAGCAUGAA
11945
cAGcuuuuGGuAGcAuGAAdTsdT
sense


 


1587-1606
9946
UUCAUGCUACCAAAAGCUG
11946
UUcAUGCuACcAAAAGCUGdTsdT
antis


 


1588-1607
9947
AGCUUUUGGUAGCAUGAAA
11947
AGcuuuuGGuAGcAuGAAAdTsdT
sense


 


1588-1607
9948
UUUCAUGCUACCAAAAGCU
11948
UUUcAUGCuACcAAAAGCUdTsdT
antis


 


1598-1617
9949
AGCAUGAAAGUUAGCAGAG
11949
AGcAuGAAAGuuAGcAGAGdTsdT
sense


 


1598-1617
9950
CUCUGCUAACUUUCAUGCU
11950
CUCUGCuAACUUUcAUGCUdTsdT
antis


 


1602-1621
9951
UGAAAGUUAGCAGAGAUAA
11951
uGAAAGuuAGcAGAGAuAAdTsdT
sense


 


1602-1621
9952
UUAUCUCUGCUAACUUUCA
11952
UuAUCUCUGCuAACUUUcAdTsdT
antis


 


1618-1637
9953
UAAAGAUGGCAGCAAGGUA
11953
uAAAGAuGGcAGcAAGGuAdTsdT
sense


 


1618-1637
9954
UACCUUGCUGCCAUCUUUA
11954
uACCUUGCUGCcAUCUUuAdTsdT
antis


 


1619-1638
9955
AAAGAUGGCAGCAAGGUAA
11955
AAAGAuGGcAGcAAGGuAAdTsdT
sense


 


1619-1638
9956
UUACCUUGCUGCCAUCUUU
11956
UuACCUUGCUGCcAUCUUUdTsdT
antis


 


1625-1644
9957
GGCAGCAAGGUAACCACAG
11957
GGcAGcAAGGuAAccAcAGdTsdT
sense


 


1625-1644
9958
CUGUGGUUACCUUGCUGCC
11958
CUGUGGUuACCUUGCUGCCdTsdT
antis


 


1627-1646
9959
CAGCAAGGUAACCACAGUA
11959
cAGcAAGGuAAccAcAGuAdTsdT
sense


 


1627-1646
9960
UACUGUGGUUACCUUGCUG
11960
uACUGUGGUuACCUUGCUGdTsdT
antis


 


1636-1655
9961
AACCACAGUAGUGGCAACU
11961
AAccAcAGuAGuGGcAAcudTsdT
sense


 


1636-1655
9962
AGUUGCCACUACUGUGGUU
11962
AGUUGCcACuACUGUGGUUdTsdT
antis


 


1637-1656
9963
ACCACAGUAGUGGCAACUC
11963
AccAcAGuAGuGGcAAcucdTsdT
sense


 


1637-1656
9964
GAGUUGCCACUACUGUGGU
11964
GAGUUGCcACuACUGUGGUdTsdT
antis


 


1646-1665
9965
GUGGCAACUCCUGGCCAGG
11965
GuGGcAAcuccuGGccAGGdTsdT
sense


 


1646-1665
9966
CCUGGCCAGGAGUUGCCAC
11966
CCUGGCcAGGAGUUGCcACdTsdT
antis


 


1648-1667
9967
GGCAACUCCUGGCCAGGGU
11967
GGcAAcuccuGGccAGGGudTsdT
sense


 


1648-1667
9968
ACCCUGGCCAGGAGUUGCC
11968
ACCCUGGCcAGGAGUUGCCdTsdT
antis


 


1649-1668
9969
GCAACUCCUGGCCAGGGUC
11969
GcAAcuccuGGccAGGGucdTsdT
sense


 


1649-1668
9970
GACCCUGGCCAGGAGUUGC
11970
GACCCUGGCcAGGAGUUGCdTsdT
antis


 


1651-1670
9971
AACUCCUGGCCAGGGUCCU
11971
AAcuccuGGccAGGGuccudTsdT
sense


 


1651-1670
9972
AGGACCCUGGCCAGGAGUU
11972
AGGACCCUGGCcAGGAGUUdTsdT
antis


 


1666-1685
9973
UCCUGACAGGCCACAGGAA
11973
uccuGAcAGGccAcAGGAAdTsdT
sense


 


1666-1685
9974
UUCCUGUGGCCUGUCAGGA
11974
UUCCUGUGGCCUGUcAGGAdTsdT
antis


 


1667-1686
9975
CCUGACAGGCCACAGGAAG
11975
ccuGAcAGGccAcAGGAAGdTsdT
sense


 


1667-1686
9976
CUUCCUGUGGCCUGUCAGG
11976
CUUCCUGUGGCCUGUcAGGdTsdT
antis


 


1669-1688
9977
UGACAGGCCACAGGAAGUC
11977
uGAcAGGccAcAGGAAGucdTsdT
sense


 


1669-1688
9978
GACUUCCUGUGGCCUGUCA
11978
GACUUCCUGUGGCCUGUcAdTsdT
antis


 


1670-1689
9979
GACAGGCCACAGGAAGUCA
11979
GAcAGGccAcAGGAAGucAdTsdT
sense


 


1670-1689
9980
UGACUUCCUGUGGCCUGUC
11980
UGACUUCCUGUGGCCUGUCdTsdT
antis


 


1685-1704
9981
GUCAGUUAUACAGACACGA
11981
GucAGuuAuAcAGAcAcGAdTsdT
sense


 


1685-1704
9982
UCGUGUCUGUAUAACUGAC
11982
UCGUGUCUGuAuAACUGACdTsdT
antis


 


1687-1706
9983
CAGUUAUACAGACACGAAA
11983
cAGuuAuAcAGAcAcGAAAdTsdT
sense


 


1687-1706
9984
UUUCGUGUCUGUAUAACUG
11984
UUUCGUGUCUGuAuAACUGdTsdT
antis


 


1689-1708
9985
GUUAUACAGACACGAAAGU
11985
GuuAuAcAGAcAcGAAAGudTsdT
sense


 


1689-1708
9986
ACUUUCGUGUCUGUAUAAC
11986
ACUUUCGUGUCUGuAuAACdTsdT
antis


 


1691-1710
9987
UAUACAGACACGAAAGUGA
11987
uAuAcAGAcAcGAAAGuGAdTsdT
sense


 


1691-1710
9988
UCACUUUCGUGUCUGUAUA
11988
UcACUUUCGUGUCUGuAuAdTsdT
antis


 


1693-1712
9989
UACAGACACGAAAGUGAUU
11989
uAcAGAcAcGAAAGuGAuudTsdT
sense


 


1693-1712
9990
AAUCACUUUCGUGUCUGUA
11990
AAUcACUUUCGUGUCUGuAdTsdT
antis


 


1701-1720
9991
CGAAAGUGAUUGGAAAUGG
11991
cGAAAGuGAuuGGAAAuGGdTsdT
sense


 


1701-1720
9992
CCAUUUCCAAUCACUUUCG
11992
CcAUUUCcAAUcACUUUCGdTsdT
antis


 


1707-1726
9993
UGAUUGGAAAUGGAUCAUU
11993
uGAuuGGAAAuGGAucAuudTsdT
sense


 


1707-1726
9994
AAUGAUCCAUUUCCAAUCA
11994
AAUGAUCcAUUUCcAAUcAdTsdT
antis


 


1717-1736
9995
UGGAUCAUUUGGUGUGGUA
11995
uGGAucAuuuGGuGuGGuAdTsdT
sense


 


1717-1736
9996
UACCACACCAAAUGAUCCA
11996
uACcAcACcAAAUGAUCcAdTsdT
antis


 


1721-1740
9997
UCAUUUGGUGUGGUAUAUC
11997
ucAuuuGGuGuGGuAuAucdTsdT
sense


 


1721-1740
9998
GAUAUACCACACCAAAUGA
11998
GAuAuACcAcACcAAAUGAdTsdT
antis


 


1729-1748
9999
UGUGGUAUAUCAAGCCAAA
11999
uGuGGuAuAucAAGccAAAdTsdT
sense


 


1729-1748
10000
UUUGGCUUGAUAUACCACA
12000
UUUGGCUUGAuAuACcAcAdTsdT
antis


 


1734-1753
10001
UAUAUCAAGCCAAACUUUG
12001
uAuAucAAGccAAAcuuuGdTsdT
sense


 


1734-1753
10002
CAAAGUUUGGCUUGAUAUA
12002
cAAAGUUUGGCUUGAuAuAdTsdT
antis


 


1736-1755
10003
UAUCAAGCCAAACUUUGUG
12003
uAucAAGccAAAcuuuGuGdTsdT
sense


 


1736-1755
10004
CACAAAGUUUGGCUUGAUA
12004
cAcAAAGUUUGGCUUGAuAdTsdT
antis


 


1737-1756
10005
AUCAAGCCAAACUUUGUGA
12005
AucAAGccAAAcuuuGuGAdTsdT
sense


 


1737-1756
10006
UCACAAAGUUUGGCUUGAU
12006
UcAcAAAGUUUGGCUUGAUdTsdT
antis


 


1749-1768
10007
UUUGUGAUUCUGGAGAACU
12007
uuuGuGAuucuGGAGAAcudTsdT
sense


 


1749-1768
10008
AGUUCUCCAGAAUCACAAA
12008
AGUUCUCcAGAAUcAcAAAdTsdT
antis


 


1759-1778
10009
UGGAGAACUGGUUGCCAUC
12009
uGGAGAAcuGGuuGccAucdTsdT
sense


 


1759-1778
10010
GAUGGCAACCAGUUCUCCA
12010
GAUGGcAACcAGUUCUCcAdTsdT
antis


 


1760-1779
10011
GGAGAACUGGUUGCCAUCA
12011
GGAGAAcuGGuuGccAucAdTsdT
sense


 


1760-1779
10012
UGAUGGCAACCAGUUCUCC
12012
UGAUGGcAACcAGUUCUCCdTsdT
antis


 


1767-1786
10013
UGGUUGCCAUCAAGAAAGU
12013
uGGuuGccAucAAGAAAGudTsdT
sense


 


1767-1786
10014
ACUUUCUUGAUGGCAACCA
12014
ACUUUCUUGAUGGcAACcAdTsdT
antis


 


1769-1788
10015
GUUGCCAUCAAGAAAGUUC
12015
GuuGccAucAAGAAAGuucdTsdT
sense


 


1769-1788
10016
GAACUUUCUUGAUGGCAAC
12016
GAACUUUCUUGAUGGcAACdTsdT
antis


 


1770-1789
10017
UUGCCAUCAAGAAAGUUCU
12017
uuGccAucAAGAAAGuucudTsdT
sense


 


1770-1789
10018
AGAACUUUCUUGAUGGCAA
12018
AGAACUUUCUUGAUGGcAAdTsdT
antis


 


1775-1794
10019
AUCAAGAAAGUUCUACAGG
12019
AucAAGAAAGuucuAcAGGdTsdT
sense


 


1775-1794
10020
CCUGUAGAACUUUCUUGAU
12020
CCUGuAGAACUUUCUUGAUdTsdT
antis


 


1783-1802
10021
AGUUCUACAGGACAAGCGA
12021
AGuucuAcAGGAcAAGcGAdTsdT
sense


 


1783-1802
10022
UCGCUUGUCCUGUAGAACU
12022
UCGCUUGUCCUGuAGAACUdTsdT
antis


 


1787-1806
10023
CUACAGGACAAGCGAUUUA
12023
cuAcAGGAcAAGcGAuuuAdTsdT
sense


 


1787-1806
10024
UAAAUCGCUUGUCCUGUAG
12024
uAAAUCGCUUGUCCUGuAGdTsdT
antis


 


1806-1825
10025
AGAACCGAGAGCUCCAGAU
12025
AGAAccGAGAGcuccAGAudTsdT
sense


 


1806-1825
10026
AUCUGGAGCUCUCGGUUCU
12026
AUCUGGAGCUCUCGGUUCUdTsdT
antis


 


1810-1829
10027
CCGAGAGCUCCAGAUCAUG
12027
ccGAGAGcuccAGAucAuGdTsdT
sense


 


1810-1829
10028
CAUGAUCUGGAGCUCUCGG
12028
cAUGAUCUGGAGCUCUCGGdTsdT
antis


 


1815-1834
10029
AGCUCCAGAUCAUGAGAAA
12029
AGcuccAGAucAuGAGAAAdTsdT
sense


 


1815-1834
10030
UUUCUCAUGAUCUGGAGCU
12030
UUUCUcAUGAUCUGGAGCUdTsdT
antis


 


1816-1835
10031
GCUCCAGAUCAUGAGAAAG
12031
GcuccAGAucAuGAGAAAGdTsdT
sense


 


1816-1835
10032
CUUUCUCAUGAUCUGGAGC
12032
CUUUCUcAUGAUCUGGAGCdTsdT
antis


 


1817-1836
10033
CUCCAGAUCAUGAGAAAGC
12033
cuccAGAucAuGAGAAAGcdTsdT
sense


 


1817-1836
10034
GCUUUCUCAUGAUCUGGAG
12034
GCUUUCUcAUGAUCUGGAGdTsdT
antis


 


1820-1839
10035
CAGAUCAUGAGAAAGCUAG
12035
cAGAucAuGAGAAAGcuAGdTsdT
sense


 


1820-1839
10036
CUAGCUUUCUCAUGAUCUG
12036
CuAGCUUUCUcAUGAUCUGdTsdT
antis


 


1824-1843
10037
UCAUGAGAAAGCUAGACCA
12037
ucAuGAGAAAGcuAGAccAdTsdT
sense


 


1824-1843
10038
UGGUCUAGCUUUCUCAUGA
12038
UGGUCuAGCUUUCUcAUGAdTsdT
antis


 


1825-1844
10039
CAUGAGAAAGCUAGACCAC
12039
cAuGAGAAAGcuAGAccAcdTsdT
sense


 


1825-1844
10040
GUGGUCUAGCUUUCUCAUG
12040
GUGGUCuAGCUUUCUcAUGdTsdT
antis


 


1826-1845
10041
AUGAGAAAGCUAGACCACU
12041
AuGAGAAAGcuAGAccAcudTsdT
sense


 


1826-1845
10042
AGUGGUCUAGCUUUCUCAU
12042
AGUGGUCuAGCUUUCUcAUdTsdT
antis


 


1858-1877
10043
ACUGCGGUAUUUCUUCUAC
12043
AcuGcGGuAuuucuucuAcdTsdT
sense


 


1858-1877
10044
GUAGAAGAAAUACCGCAGU
12044
GuAGAAGAAAuACCGcAGUdTsdT
antis


 


1866-1885
10045
AUUUCUUCUACUCGAGUGG
12045
AuuucuucuAcucGAGuGGdTsdT
sense


 


1866-1885
10046
CCACUCGAGUAGAAGAAAU
12046
CcACUCGAGuAGAAGAAAUdTsdT
antis


 


1869-1888
10047
UCUUCUACUCGAGUGGUGA
12047
ucuucuAcucGAGuGGuGAdTsdT
sense


 


1869-1888
10048
UCACCACUCGAGUAGAAGA
12048
UcACcACUCGAGuAGAAGAdTsdT
antis


 


1878-1897
10049
CGAGUGGUGAGAAGAAAGA
12049
cGAGuGGuGAGAAGAAAGAdTsdT
sense


 


1878-1897
10050
UCUUUCUUCUCACCACUCG
12050
UCUUUCUUCUcACcACUCGdTsdT
antis


 


1890-1909
10051
AGAAAGAUGAGGUCUACCU
12051
AGAAAGAuGAGGucuAccudTsdT
sense


 


1890-1909
10052
AGGUAGACCUCAUCUUUCU
12052
AGGuAGACCUcAUCUUUCUdTsdT
antis


 


1891-1910
10053
GAAAGAUGAGGUCUACCUU
12053
GAAAGAuGAGGucuAccuudTsdT
sense


 


1891-1910
10054
AAGGUAGACCUCAUCUUUC
12054
AAGGuAGACCUcAUCUUUCdTsdT
antis


 


1898-1917
10055
GAGGUCUACCUUAACCUGG
12055
GAGGucuAccuuAAccuGGdTsdT
sense


 


1898-1917
10056
CCAGGUUAAGGUAGACCUC
12056
CcAGGUuAAGGuAGACCUCdTsdT
antis


 


1903-1922
10057
CUACCUUAACCUGGUGCUG
12057
cuAccuuAAccuGGuGcuGdTsdT
sense


 


1903-1922
10058
CAGCACCAGGUUAAGGUAG
12058
cAGcACcAGGUuAAGGuAGdTsdT
antis


 


1911-1930
10059
ACCUGGUGCUGGACUAUGU
12059
AccuGGuGcuGGAcuAuGudTsdT
sense


 


1911-1930
10060
ACAUAGUCCAGCACCAGGU
12060
AcAuAGUCcAGcACcAGGUdTsdT
antis


 


1912-1931
10061
CCUGGUGCUGGACUAUGUU
12061
ccuGGuGcuGGAcuAuGuudTsdT
sense


 


1912-1931
10062
AACAUAGUCCAGCACCAGG
12062
AAcAuAGUCcAGcACcAGGdTsdT
antis


 


1915-1934
10063
GGUGCUGGACUAUGUUCCG
12063
GGuGcuGGAcuAuGuuccGdTsdT
sense


 


1915-1934
10064
CGGAACAUAGUCCAGCACC
12064
CGGAAcAuAGUCcAGcACCdTsdT
antis


 


1929-1948
10065
UUCCGGAGACAGUGUACAG
12065
uuccGGAGAcAGuGuAcAGdTsdT
sense


 


1929-1948
10066
CUGUACACUGUCUCCGGAA
12066
CUGuAcACUGUCUCCGGAAdTsdT
antis


 


1933-1952
10067
GGAGACAGUGUACAGAGUC
12067
GGAGAcAGuGuAcAGAGucdTsdT
sense


 


1933-1952
10068
GACUCUGUACACUGUCUCC
12068
GACUCUGuAcACUGUCUCCdTsdT
antis


 


1935-1954
10069
AGACAGUGUACAGAGUCGC
12069
AGAcAGuGuAcAGAGucGcdTsdT
sense


 


1935-1954
10070
GCGACUCUGUACACUGUCU
12070
GCGACUCUGuAcACUGUCUdTsdT
antis


 


1941-1960
10071
UGUACAGAGUCGCCAGACA
12071
uGuAcAGAGucGccAGAcAdTsdT
sense


 


1941-1960
10072
UGUCUGGCGACUCUGUACA
12072
UGUCUGGCGACUCUGuAcAdTsdT
antis


 


1944-1963
10073
ACAGAGUCGCCAGACACUA
12073
AcAGAGucGccAGAcAcuAdTsdT
sense


 


1944-1963
10074
UAGUGUCUGGCGACUCUGU
12074
uAGUGUCUGGCGACUCUGUdTsdT
antis


 


1945-1964
10075
CAGAGUCGCCAGACACUAU
12075
cAGAGucGccAGAcAcuAudTsdT
sense


 


1945-1964
10076
AUAGUGUCUGGCGACUCUG
12076
AuAGUGUCUGGCGACUCUGdTsdT
antis


 


1965-1984
10077
GUCGAGCCAAGCAGACACU
12077
GucGAGccAAGcAGAcAcudTsdT
sense


 


1965-1984
10078
AGUGUCUGCUUGGCUCGAC
12078
AGUGUCUGCUUGGCUCGACdTsdT
antis


 


1966-1985
10079
UCGAGCCAAGCAGACACUC
12079
ucGAGccAAGcAGAcAcucdTsdT
sense


 


1966-1985
10080
GAGUGUCUGCUUGGCUCGA
12080
GAGUGUCUGCUUGGCUCGAdTsdT
antis


 


1967-1986
10081
CGAGCCAAGCAGACACUCC
12081
cGAGccAAGcAGAcAcuccdTsdT
sense


 


1967-1986
10082
GGAGUGUCUGCUUGGCUCG
12082
GGAGUGUCUGCUUGGCUCGdTsdT
antis


 


1970-1989
10083
GCCAAGCAGACACUCCCUG
12083
GccAAGcAGAcAcucccuGdTsdT
sense


 


1970-1989
10084
CAGGGAGUGUCUGCUUGGC
12084
cAGGGAGUGUCUGCUUGGCdTsdT
antis


 


1971-1990
10085
CCAAGCAGACACUCCCUGU
12085
ccAAGcAGAcAcucccuGudTsdT
sense


 


1971-1990
10086
ACAGGGAGUGUCUGCUUGG
12086
AcAGGGAGUGUCUGCUUGGdTsdT
antis


 


1974-1993
10087
AGCAGACACUCCCUGUGAU
12087
AGcAGAcAcucccuGuGAudTsdT
sense


 


1974-1993
10088
AUCACAGGGAGUGUCUGCU
12088
AUcAcAGGGAGUGUCUGCUdTsdT
antis


 


1975-1994
10089
GCAGACACUCCCUGUGAUC
12089
GcAGAcAcucccuGuGAucdTsdT
sense


 


1975-1994
10090
GAUCACAGGGAGUGUCUGC
12090
GAUcAcAGGGAGUGUCUGCdTsdT
antis


 


1986-2005
10091
CUGUGAUCUAUGUCAAGUU
12091
cuGuGAucuAuGucAAGuudTsdT
sense


 


1986-2005
10092
AACUUGACAUAGAUCACAG
12092
AACUUGAcAuAGAUcAcAGdTsdT
antis


 


1993-2012
10093
CUAUGUCAAGUUGUAUAUG
12093
cuAuGucAAGuuGuAuAuGdTsdT
sense


 


1993-2012
10094
CAUAUACAACUUGACAUAG
12094
cAuAuAcAACUUGAcAuAGdTsdT
antis


 


1995-2014
10095
AUGUCAAGUUGUAUAUGUA
12095
AuGucAAGuuGuAuAuGuAdTsdT
sense


 


1995-2014
10096
UACAUAUACAACUUGACAU
12096
uAcAuAuAcAACUUGAcAUdTsdT
antis


 


1996-2015
10097
UGUCAAGUUGUAUAUGUAU
12097
uGucAAGuuGuAuAuGuAudTsdT
sense


 


1996-2015
10098
AUACAUAUACAACUUGACA
12098
AuAcAuAuAcAACUUGAcAdTsdT
antis


 


1999-2018
10099
CAAGUUGUAUAUGUAUCAG
12099
cAAGuuGuAuAuGuAucAGdTsdT
sense


 


1999-2018
10100
CUGAUACAUAUACAACUUG
12100
CUGAuAcAuAuAcAACUUGdTsdT
antis


 


2009-2028
10101
AUGUAUCAGCUGUUCAGAA
12101
AuGuAucAGcuGuucAGAAdTsdT
sense


 


2009-2028
10102
UUCUGAACAGCUGAUACAU
12102
UUCUGAAcAGCUGAuAcAUdTsdT
antis


 


2010-2029
10103
UGUAUCAGCUGUUCAGAAG
12103
uGuAucAGcuGuucAGAAGdTsdT
sense


 


2010-2029
10104
CUUCUGAACAGCUGAUACA
12104
CUUCUGAAcAGCUGAuAcAdTsdT
antis


 


2016-2035
10105
AGCUGUUCAGAAGUCUAGC
12105
AGcuGuucAGAAGucuAGcdTsdT
sense


 


2016-2035
10106
GCUAGACUUCUGAACAGCU
12106
GCuAGACUUCUGAAcAGCUdTsdT
antis


 


2035-2054
10107
CUAUAUCCAUUCCUUUGGA
12107
cuAuAuccAuuccuuuGGAdTsdT
sense


 


2035-2054
10108
UCCAAAGGAAUGGAUAUAG
12108
UCcAAAGGAAUGGAuAuAGdTsdT
antis


 


2036-2055
10109
UAUAUCCAUUCCUUUGGAA
12109
uAuAuccAuuccuuuGGAAdTsdT
sense


 


2036-2055
10110
UUCCAAAGGAAUGGAUAUA
12110
UUCcAAAGGAAUGGAuAuAdTsdT
antis


 


2046-2065
10111
CCUUUGGAAUCUGCCAUCG
12111
ccuuuGGAAucuGccAucGdTsdT
sense


 


2046-2065
10112
CGAUGGCAGAUUCCAAAGG
12112
CGAUGGcAGAUUCcAAAGGdTsdT
antis


 


2049-2068
10113
UUGGAAUCUGCCAUCGAGA
12113
uuGGAAucuGccAucGAGAdTsdT
sense


 


2049-2068
10114
UCUCGAUGGCAGAUUCCAA
12114
UCUCGAUGGcAGAUUCcAAdTsdT
antis


 


2051-2070
10115
GGAAUCUGCCAUCGAGACA
12115
GGAAucuGccAucGAGAcAdTsdT
sense


 


2051-2070
10116
UGUCUCGAUGGCAGAUUCC
12116
UGUCUCGAUGGcAGAUUCCdTsdT
antis


 


2068-2087
10117
CAUUAAACCACAGAACCUC
12117
cAuuAAAccAcAGAAccucdTsdT
sense


 


2068-2087
10118
GAGGUUCUGUGGUUUAAUG
12118
GAGGUUCUGUGGUUuAAUGdTsdT
antis


 


2070-2089
10119
UUAAACCACAGAACCUCUU
12119
uuAAAccAcAGAAccucuudTsdT
sense


 


2070-2089
10120
AAGAGGUUCUGUGGUUUAA
12120
AAGAGGUUCUGUGGUUuAAdTsdT
antis


 


2071-2090
10121
UAAACCACAGAACCUCUUG
12121
uAAAccAcAGAAccucuuGdTsdT
sense


 


2071-2090
10122
CAAGAGGUUCUGUGGUUUA
12122
cAAGAGGUUCUGUGGUUuAdTsdT
antis


 


2073-2092
10123
AACCACAGAACCUCUUGUU
12123
AAccAcAGAAccucuuGuudTsdT
sense


 


2073-2092
10124
AACAAGAGGUUCUGUGGUU
12124
AAcAAGAGGUUCUGUGGUUdTsdT
antis


 


2075-2094
10125
CCACAGAACCUCUUGUUGG
12125
ccAcAGAAccucuuGuuGGdTsdT
sense


 


2075-2094
10126
CCAACAAGAGGUUCUGUGG
12126
CcAAcAAGAGGUUCUGUGGdTsdT
antis


 


2076-2095
10127
CACAGAACCUCUUGUUGGA
12127
cAcAGAAccucuuGuuGGAdTsdT
sense


 


2076-2095
10128
UCCAACAAGAGGUUCUGUG
12128
UCcAAcAAGAGGUUCUGUGdTsdT
antis


 


2078-2097
10129
CAGAACCUCUUGUUGGAUC
12129
cAGAAccucuuGuuGGAucdTsdT
sense


 


2078-2097
10130
GAUCCAACAAGAGGUUCUG
12130
GAUCcAAcAAGAGGUUCUGdTsdT
antis


 


2084-2103
10131
CUCUUGUUGGAUCCUGAUA
12131
cucuuGuuGGAuccuGAuAdTsdT
sense


 


2084-2103
10132
UAUCAGGAUCCAACAAGAG
12132
uAUcAGGAUCcAAcAAGAGdTsdT
antis


 


2086-2105
10133
CUUGUUGGAUCCUGAUACA
12133
cuuGuuGGAuccuGAuAcAdTsdT
sense


 


2086-2105
10134
UGUAUCAGGAUCCAACAAG
12134
UGuAUcAGGAUCcAAcAAGdTsdT
antis


 


2095-2114
10135
UCCUGAUACAGCUGUAUUA
12135
uccuGAuAcAGcuGuAuuAdTsdT
sense


 


2095-2114
10136
UAAUACAGCUGUAUCAGGA
12136
uAAuAcAGCUGuAUcAGGAdTsdT
antis


 


2102-2121
10137
ACAGCUGUAUUAAAACUCU
12137
AcAGcuGuAuuAAAAcucudTsdT
sense


 


2102-2121
10138
AGAGUUUUAAUACAGCUGU
12138
AGAGUUUuAAuAcAGCUGUdTsdT
antis


 


2103-2122
10139
CAGCUGUAUUAAAACUCUG
12139
cAGcuGuAuuAAAAcucuGdTsdT
sense


 


2103-2122
10140
CAGAGUUUUAAUACAGCUG
12140
cAGAGUUUuAAuAcAGCUGdTsdT
antis


 


2105-2124
10141
GCUGUAUUAAAACUCUGUG
12141
GcuGuAuuAAAAcucuGuGdTsdT
sense


 


2105-2124
10142
CACAGAGUUUUAAUACAGC
12142
cAcAGAGUUUuAAuAcAGCdTsdT
antis


 


2106-2125
10143
CUGUAUUAAAACUCUGUGA
12143
cuGuAuuAAAAcucuGuGAdTsdT
sense


 


2106-2125
10144
UCACAGAGUUUUAAUACAG
12144
UcAcAGAGUUUuAAuAcAGdTsdT
antis


 


2108-2127
10145
GUAUUAAAACUCUGUGACU
12145
GuAuuAAAAcucuGuGAcudTsdT
sense


 


2108-2127
10146
AGUCACAGAGUUUUAAUAC
12146
AGUcAcAGAGUUUuAAuACdTsdT
antis


 


2115-2134
10147
AACUCUGUGACUUUGGAAG
12147
AAcucuGuGAcuuuGGAAGdTsdT
sense


 


2115-2134
10148
CUUCCAAAGUCACAGAGUU
12148
CUUCcAAAGUcAcAGAGUUdTsdT
antis


 


2120-2139
10149
UGUGACUUUGGAAGUGCAA
12149
uGuGAcuuuGGAAGuGcAAdTsdT
sense


 


2120-2139
10150
UUGCACUUCCAAAGUCACA
12150
UUGcACUUCcAAAGUcAcAdTsdT
antis


 


2124-2143
10151
ACUUUGGAAGUGCAAAGCA
12151
AcuuuGGAAGuGcAAAGcAdTsdT
sense


 


2124-2143
10152
UGCUUUGCACUUCCAAAGU
12152
UGCUUUGcACUUCcAAAGUdTsdT
antis


 


2132-2151
10153
AGUGCAAAGCAGCUGGUCC
12153
AGuGcAAAGcAGcuGGuccdTsdT
sense


 


2132-2151
10154
GGACCAGCUGCUUUGCACU
12154
GGACcAGCUGCUUUGcACUdTsdT
antis


 


2134-2153
10155
UGCAAAGCAGCUGGUCCGA
12155
uGcAAAGcAGcuGGuccGAdTsdT
sense


 


2134-2153
10156
UCGGACCAGCUGCUUUGCA
12156
UCGGACcAGCUGCUUUGcAdTsdT
antis


 


2136-2155
10157
CAAAGCAGCUGGUCCGAGG
12157
cAAAGcAGcuGGuccGAGGdTsdT
sense


 


2136-2155
10158
CCUCGGACCAGCUGCUUUG
12158
CCUCGGACcAGCUGCUUUGdTsdT
antis


 


2139-2158
10159
AGCAGCUGGUCCGAGGAGA
12159
AGcAGcuGGuccGAGGAGAdTsdT
sense


 


2139-2158
10160
UCUCCUCGGACCAGCUGCU
12160
UCUCCUCGGACcAGCUGCUdTsdT
antis


 


2140-2159
10161
GCAGCUGGUCCGAGGAGAG
12161
GcAGcuGGuccGAGGAGAGdTsdT
sense


 


2140-2159
10162
CUCUCCUCGGACCAGCUGC
12162
CUCUCCUCGGACcAGCUGCdTsdT
antis


 


2141-2160
10163
CAGCUGGUCCGAGGAGAGC
12163
cAGcuGGuccGAGGAGAGcdTsdT
sense


 


2141-2160
10164
GCUCUCCUCGGACCAGCUG
12164
GCUCUCCUCGGACcAGCUGdTsdT
antis


 


2142-2161
10165
AGCUGGUCCGAGGAGAGCC
12165
AGcuGGuccGAGGAGAGccdTsdT
sense


 


2142-2161
10166
GGCUCUCCUCGGACCAGCU
12166
GGCUCUCCUCGGACcAGCUdTsdT
antis


 


2146-2165
10167
GGUCCGAGGAGAGCCCAAU
12167
GGuccGAGGAGAGcccAAudTsdT
sense


 


2146-2165
10168
AUUGGGCUCUCCUCGGACC
12168
AUUGGGCUCUCCUCGGACCdTsdT
antis


 


2147-2166
10169
GUCCGAGGAGAGCCCAAUG
12169
GuccGAGGAGAGcccAAuGdTsdT
sense


 


2147-2166
10170
CAUUGGGCUCUCCUCGGAC
12170
cAUUGGGCUCUCCUCGGACdTsdT
antis


 


2160-2179
10171
CCAAUGUUUCAUAUAUCUG
12171
ccAAuGuuucAuAuAucuGdTsdT
sense


 


2160-2179
10172
CAGAUAUAUGAAACAUUGG
12172
cAGAuAuAUGAAAcAUUGGdTsdT
antis


 


2189-2208
10173
UACAGGGCACCAGAGUUGA
12173
uAcAGGGcAccAGAGuuGAdTsdT
sense


 


2189-2208
10174
UCAACUCUGGUGCCCUGUA
12174
UcAACUCUGGUGCCCUGuAdTsdT
antis


 


2191-2210
10175
CAGGGCACCAGAGUUGAUC
12175
cAGGGcAccAGAGuuGAucdTsdT
sense


 


2191-2210
10176
GAUCAACUCUGGUGCCCUG
12176
GAUcAACUCUGGUGCCCUGdTsdT
antis


 


2194-2213
10177
GGCACCAGAGUUGAUCUUU
12177
GGcAccAGAGuuGAucuuudTsdT
sense


 


2194-2213
10178
AAAGAUCAACUCUGGUGCC
12178
AAAGAUcAACUCUGGUGCCdTsdT
antis


 


2195-2214
10179
GCACCAGAGUUGAUCUUUG
12179
GcAccAGAGuuGAucuuuGdTsdT
sense


 


2195-2214
10180
CAAAGAUCAACUCUGGUGC
12180
cAAAGAUcAACUCUGGUGCdTsdT
antis


 


2196-2215
10181
CACCAGAGUUGAUCUUUGG
12181
cAccAGAGuuGAucuuuGGdTsdT
sense


 


2196-2215
10182
CCAAAGAUCAACUCUGGUG
12182
CcAAAGAUcAACUCUGGUGdTsdT
antis


 


2201-2220
10183
GAGUUGAUCUUUGGAGCCA
12183
GAGuuGAucuuuGGAGccAdTsdT
sense


 


2201-2220
10184
UGGCUCCAAAGAUCAACUC
12184
UGGCUCcAAAGAUcAACUCdTsdT
antis


 


2211-2230
10185
UUGGAGCCACUGAUUACAC
12185
uuGGAGccAcuGAuuAcAcdTsdT
sense


 


2211-2230
10186
GUGUAAUCAGUGGCUCCAA
12186
GUGuAAUcAGUGGCUCcAAdTsdT
antis


 


2234-2253
10187
AGUAUAGAUGUAUGGUCUG
12187
AGuAuAGAuGuAuGGucuGdTsdT
sense


 


2234-2253
10188
CAGACCAUACAUCUAUACU
12188
cAGACcAuAcAUCuAuACUdTsdT
antis


 


2238-2257
10189
UAGAUGUAUGGUCUGCAGG
12189
uAGAuGuAuGGucuGcAGGdTsdT
sense


 


2238-2257
10190
CCUGCAGACCAUACAUCUA
12190
CCUGcAGACcAuAcAUCuAdTsdT
antis


 


2240-2259
10191
GAUGUAUGGUCUGCAGGCU
12191
GAuGuAuGGucuGcAGGcudTsdT
sense


 


2240-2259
10192
AGCCUGCAGACCAUACAUC
12192
AGCCUGcAGACcAuAcAUCdTsdT
antis


 


2241-2260
10193
AUGUAUGGUCUGCAGGCUG
12193
AuGuAuGGucuGcAGGcuGdTsdT
sense


 


2241-2260
10194
CAGCCUGCAGACCAUACAU
12194
cAGCCUGcAGACcAuAcAUdTsdT
antis


 


2242-2261
10195
UGUAUGGUCUGCAGGCUGU
12195
uGuAuGGucuGcAGGcuGudTsdT
sense


 


2242-2261
10196
ACAGCCUGCAGACCAUACA
12196
AcAGCCUGcAGACcAuAcAdTsdT
antis


 


2249-2268
10197
UCUGCAGGCUGUGUGUUGG
12197
ucuGcAGGcuGuGuGuuGGdTsdT
sense


 


2249-2268
10198
CCAACACACAGCCUGCAGA
12198
CcAAcAcAcAGCCUGcAGAdTsdT
antis


 


2255-2274
10199
GGCUGUGUGUUGGCUGAAU
12199
GGcuGuGuGuuGGcuGAAudTsdT
sense


 


2255-2274
10200
AUUCAGCCAACACACAGCC
12200
AUUcAGCcAAcAcAcAGCCdTsdT
antis


 


2256-2275
10201
GCUGUGUGUUGGCUGAAUU
12201
GcuGuGuGuuGGcuGAAuudTsdT
sense


 


2256-2275
10202
AAUUCAGCCAACACACAGC
12202
AAUUcAGCcAAcAcAcAGCdTsdT
antis


 


2257-2276
10203
CUGUGUGUUGGCUGAAUUG
12203
cuGuGuGuuGGcuGAAuuGdTsdT
sense


 


2257-2276
10204
CAAUUCAGCCAACACACAG
12204
cAAUUcAGCcAAcAcAcAGdTsdT
antis


 


2259-2278
10205
GUGUGUUGGCUGAAUUGUU
12205
GuGuGuuGGcuGAAuuGuudTsdT
sense


 


2259-2278
10206
AACAAUUCAGCCAACACAC
12206
AAcAAUUcAGCcAAcAcACdTsdT
antis


 


2260-2279
10207
UGUGUUGGCUGAAUUGUUG
12207
uGuGuuGGcuGAAuuGuuGdTsdT
sense


 


2260-2279
10208
CAACAAUUCAGCCAACACA
12208
cAAcAAUUcAGCcAAcAcAdTsdT
antis


 


2271-2290
10209
AAUUGUUGCUAGGACAACC
12209
AAuuGuuGcuAGGAcAAccdTsdT
sense


 


2271-2290
10210
GGUUGUCCUAGCAACAAUU
12210
GGUUGUCCuAGcAAcAAUUdTsdT
antis


 


2280-2299
10211
UAGGACAACCAAUAUUUCC
12211
uAGGAcAAccAAuAuuuccdTsdT
sense


 


2280-2299
10212
GGAAAUAUUGGUUGUCCUA
12212
GGAAAuAUUGGUUGUCCuAdTsdT
antis


 


2284-2303
10213
ACAACCAAUAUUUCCUGGG
12213
AcAAccAAuAuuuccuGGGdTsdT
sense


 


2284-2303
10214
CCCAGGAAAUAUUGGUUGU
12214
CCcAGGAAAuAUUGGUUGUdTsdT
antis


 


2287-2306
10215
ACCAAUAUUUCCUGGGGAC
12215
AccAAuAuuuccuGGGGAcdTsdT
sense


 


2287-2306
10216
GUCCCCAGGAAAUAUUGGU
12216
GUCCCcAGGAAAuAUUGGUdTsdT
antis


 


2288-2307
10217
CCAAUAUUUCCUGGGGACA
12217
ccAAuAuuuccuGGGGAcAdTsdT
sense


 


2288-2307
10218
UGUCCCCAGGAAAUAUUGG
12218
UGUCCCcAGGAAAuAUUGGdTsdT
antis


 


2289-2308
10219
CAAUAUUUCCUGGGGACAG
12219
cAAuAuuuccuGGGGAcAGdTsdT
sense


 


2289-2308
10220
CUGUCCCCAGGAAAUAUUG
12220
CUGUCCCcAGGAAAuAUUGdTsdT
antis


 


2290-2309
10221
AAUAUUUCCUGGGGACAGU
12221
AAuAuuuccuGGGGAcAGudTsdT
sense


 


2290-2309
10222
ACUGUCCCCAGGAAAUAUU
12222
ACUGUCCCcAGGAAAuAUUdTsdT
antis


 


2292-2311
10223
UAUUUCCUGGGGACAGUGG
12223
uAuuuccuGGGGAcAGuGGdTsdT
sense


 


2292-2311
10224
CCACUGUCCCCAGGAAAUA
12224
CcACUGUCCCcAGGAAAuAdTsdT
antis


 


2299-2318
10225
UGGGGACAGUGGUGUGGAU
12225
uGGGGAcAGuGGuGuGGAudTsdT
sense


 


2299-2318
10226
AUCCACACCACUGUCCCCA
12226
AUCcAcACcACUGUCCCcAdTsdT
antis


 


2303-2322
10227
GACAGUGGUGUGGAUCAGU
12227
GAcAGuGGuGuGGAucAGudTsdT
sense


 


2303-2322
10228
ACUGAUCCACACCACUGUC
12228
ACUGAUCcAcACcACUGUCdTsdT
antis


 


2310-2329
10229
GUGUGGAUCAGUUGGUGGA
12229
GuGuGGAucAGuuGGuGGAdTsdT
sense


 


2310-2329
10230
UCCACCAACUGAUCCACAC
12230
UCcACcAACUGAUCcAcACdTsdT
antis


 


2316-2335
10231
AUCAGUUGGUGGAAAUAAU
12231
AucAGuuGGuGGAAAuAAudTsdT
sense


 


2316-2335
10232
AUUAUUUCCACCAACUGAU
12232
AUuAUUUCcACcAACUGAUdTsdT
antis


 


2324-2343
10233
GUGGAAAUAAUAAAGGUCC
12233
GuGGAAAuAAuAAAGGuccdTsdT
sense


 


2324-2343
10234
GGACCUUUAUUAUUUCCAC
12234
GGACCUUuAUuAUUUCcACdTsdT
antis


 


2327-2346
10235
GAAAUAAUAAAGGUCCUAG
12235
GAAAuAAuAAAGGuccuAGdTsdT
sense


 


2327-2346
10236
CUAGGACCUUUAUUAUUUC
12236
CuAGGACCUUuAUuAUUUCdTsdT
antis


 


2333-2352
10237
AUAAAGGUCCUAGGAACAC
12237
AuAAAGGuccuAGGAAcAcdTsdT
sense


 


2333-2352
10238
GUGUUCCUAGGACCUUUAU
12238
GUGUUCCuAGGACCUUuAUdTsdT
antis


 


2335-2354
10239
AAAGGUCCUAGGAACACCA
12239
AAAGGuccuAGGAAcAccAdTsdT
sense


 


2335-2354
10240
UGGUGUUCCUAGGACCUUU
12240
UGGUGUUCCuAGGACCUUUdTsdT
antis


 


2341-2360
10241
CCUAGGAACACCAACAAGG
12241
ccuAGGAAcAccAAcAAGGdTsdT
sense


 


2341-2360
10242
CCUUGUUGGUGUUCCUAGG
12242
CCUUGUUGGUGUUCCuAGGdTsdT
antis


 


2345-2364
10243
GGAACACCAACAAGGGAGC
12243
GGAAcAccAAcAAGGGAGcdTsdT
sense


 


2345-2364
10244
GCUCCCUUGUUGGUGUUCC
12244
GCUCCCUUGUUGGUGUUCCdTsdT
antis


 


2356-2375
10245
AAGGGAGCAAAUUAGAGAA
12245
AAGGGAGcAAAuuAGAGAAdTsdT
sense


 


2356-2375
10246
UUCUCUAAUUUGCUCCCUU
12246
UUCUCuAAUUUGCUCCCUUdTsdT
antis


 


2358-2377
10247
GGGAGCAAAUUAGAGAAAU
12247
GGGAGcAAAuuAGAGAAAudTsdT
sense


 


2358-2377
10248
AUUUCUCUAAUUUGCUCCC
12248
AUUUCUCuAAUUUGCUCCCdTsdT
antis


 


2364-2383
10249
AAAUUAGAGAAAUGAACCC
12249
AAAuuAGAGAAAuGAAcccdTsdT
sense


 


2364-2383
10250
GGGUUCAUUUCUCUAAUUU
12250
GGGUUcAUUUCUCuAAUUUdTsdT
antis


 


2365-2384
10251
AAUUAGAGAAAUGAACCCA
12251
AAuuAGAGAAAuGAAcccAdTsdT
sense


 


2365-2384
10252
UGGGUUCAUUUCUCUAAUU
12252
UGGGUUcAUUUCUCuAAUUdTsdT
antis


 


2368-2387
10253
UAGAGAAAUGAACCCAAAU
12253
uAGAGAAAuGAAcccAAAudTsdT
sense


 


2368-2387
10254
AUUUGGGUUCAUUUCUCUA
12254
AUUUGGGUUcAUUUCUCuAdTsdT
antis


 


2369-2388
10255
AGAGAAAUGAACCCAAAUU
12255
AGAGAAAuGAAcccAAAuudTsdT
sense


 


2369-2388
10256
AAUUUGGGUUCAUUUCUCU
12256
AAUUUGGGUUcAUUUCUCUdTsdT
antis


 


2371-2390
10257
AGAAAUGAACCCAAAUUAU
12257
AGAAAuGAAcccAAAuuAudTsdT
sense


 


2371-2390
10258
AUAAUUUGGGUUCAUUUCU
12258
AuAAUUUGGGUUcAUUUCUdTsdT
antis


 


2372-2391
10259
GAAAUGAACCCAAAUUAUA
12259
GAAAuGAAcccAAAuuAuAdTsdT
sense


 


2372-2391
10260
UAUAAUUUGGGUUCAUUUC
12260
uAuAAUUUGGGUUcAUUUCdTsdT
antis


 


2374-2393
10261
AAUGAACCCAAAUUAUACA
12261
AAuGAAcccAAAuuAuAcAdTsdT
sense


 


2374-2393
10262
UGUAUAAUUUGGGUUCAUU
12262
UGuAuAAUUUGGGUUcAUUdTsdT
antis


 


2375-2394
10263
AUGAACCCAAAUUAUACAG
12263
AuGAAcccAAAuuAuAcAGdTsdT
sense


 


2375-2394
10264
CUGUAUAAUUUGGGUUCAU
12264
CUGuAuAAUUUGGGUUcAUdTsdT
antis


 


2381-2400
10265
CCAAAUUAUACAGAAUUCA
12265
ccAAAuuAuAcAGAAuucAdTsdT
sense


 


2381-2400
10266
UGAAUUCUGUAUAAUUUGG
12266
UGAAUUCUGuAuAAUUUGGdTsdT
antis


 


2386-2405
10267
UUAUACAGAAUUCAAAUUC
12267
uuAuAcAGAAuucAAAuucdTsdT
sense


 


2386-2405
10268
GAAUUUGAAUUCUGUAUAA
12268
GAAUUUGAAUUCUGuAuAAdTsdT
antis


 


2387-2406
10269
UAUACAGAAUUCAAAUUCC
12269
uAuAcAGAAuucAAAuuccdTsdT
sense


 


2387-2406
10270
GGAAUUUGAAUUCUGUAUA
12270
GGAAUUUGAAUUCUGuAuAdTsdT
antis


 


2388-2407
10271
AUACAGAAUUCAAAUUCCC
12271
AuAcAGAAuucAAAuucccdTsdT
sense


 


2388-2407
10272
GGGAAUUUGAAUUCUGUAU
12272
GGGAAUUUGAAUUCUGuAUdTsdT
antis


 


2396-2415
10273
UUCAAAUUCCCUCAAAUCA
12273
uucAAAuucccucAAAucAdTsdT
sense


 


2396-2415
10274
UGAUUUGAGGGAAUUUGAA
12274
UGAUUUGAGGGAAUUUGAAdTsdT
antis


 


2398-2417
10275
CAAAUUCCCUCAAAUCAAG
12275
cAAAuucccucAAAucAAGdTsdT
sense


 


2398-2417
10276
CUUGAUUUGAGGGAAUUUG
12276
CUUGAUUUGAGGGAAUUUGdTsdT
antis


 


2399-2418
10277
AAAUUCCCUCAAAUCAAGG
12277
AAAuucccucAAAucAAGGdTsdT
sense


 


2399-2418
10278
CCUUGAUUUGAGGGAAUUU
12278
CCUUGAUUUGAGGGAAUUUdTsdT
antis


 


2406-2425
10279
CUCAAAUCAAGGCACAUCC
12279
cucAAAucAAGGcAcAuccdTsdT
sense


 


2406-2425
10280
GGAUGUGCCUUGAUUUGAG
12280
GGAUGUGCCUUGAUUUGAGdTsdT
antis


 


2407-2426
10281
UCAAAUCAAGGCACAUCCU
12281
ucAAAucAAGGcAcAuccudTsdT
sense


 


2407-2426
10282
AGGAUGUGCCUUGAUUUGA
12282
AGGAUGUGCCUUGAUUUGAdTsdT
antis


 


2410-2429
10283
AAUCAAGGCACAUCCUUGG
12283
AAucAAGGcAcAuccuuGGdTsdT
sense


 


2410-2429
10284
CCAAGGAUGUGCCUUGAUU
12284
CcAAGGAUGUGCCUUGAUUdTsdT
antis


 


2411-2430
10285
AUCAAGGCACAUCCUUGGA
12285
AucAAGGcAcAuccuuGGAdTsdT
sense


 


2411-2430
10286
UCCAAGGAUGUGCCUUGAU
12286
UCcAAGGAUGUGCCUUGAUdTsdT
antis


 


2413-2432
10287
CAAGGCACAUCCUUGGACA
12287
cAAGGcAcAuccuuGGAcAdTsdT
sense


 


2413-2432
10288
UGUCCAAGGAUGUGCCUUG
12288
UGUCcAAGGAUGUGCCUUGdTsdT
antis


 


2415-2434
10289
AGGCACAUCCUUGGACAAA
12289
AGGcAcAuccuuGGAcAAAdTsdT
sense


 


2415-2434
10290
UUUGUCCAAGGAUGUGCCU
12290
UUUGUCcAAGGAUGUGCCUdTsdT
antis


 


2416-2435
10291
GGCACAUCCUUGGACAAAG
12291
GGcAcAuccuuGGAcAAAGdTsdT
sense


 


2416-2435
10292
CUUUGUCCAAGGAUGUGCC
12292
CUUUGUCcAAGGAUGUGCCdTsdT
antis


 


2417-2436
10293
GCACAUCCUUGGACAAAGG
12293
GcAcAuccuuGGAcAAAGGdTsdT
sense


 


2417-2436
10294
CCUUUGUCCAAGGAUGUGC
12294
CCUUUGUCcAAGGAUGUGCdTsdT
antis


 


2418-2437
10295
CACAUCCUUGGACAAAGGU
12295
cAcAuccuuGGAcAAAGGudTsdT
sense


 


2418-2437
10296
ACCUUUGUCCAAGGAUGUG
12296
ACCUUUGUCcAAGGAUGUGdTsdT
antis


 


2420-2439
10297
CAUCCUUGGACAAAGGUCU
12297
cAuccuuGGAcAAAGGucudTsdT
sense


 


2420-2439
10298
AGACCUUUGUCCAAGGAUG
12298
AGACCUUUGUCcAAGGAUGdTsdT
antis


 


2422-2441
10299
UCCUUGGACAAAGGUCUUC
12299
uccuuGGAcAAAGGucuucdTsdT
sense


 


2422-2441
10300
GAAGACCUUUGUCCAAGGA
12300
GAAGACCUUUGUCcAAGGAdTsdT
antis


 


2426-2445
10301
UGGACAAAGGUCUUCCGGC
12301
uGGAcAAAGGucuuccGGcdTsdT
sense


 


2426-2445
10302
GCCGGAAGACCUUUGUCCA
12302
GCCGGAAGACCUUUGUCcAdTsdT
antis


 


2430-2449
10303
CAAAGGUCUUCCGGCCCCG
12303
cAAAGGucuuccGGccccGdTsdT
sense


 


2430-2449
10304
CGGGGCCGGAAGACCUUUG
12304
CGGGGCCGGAAGACCUUUGdTsdT
antis


 


2439-2458
10305
UCCGGCCCCGAACUCCACC
12305
uccGGccccGAAcuccAccdTsdT
sense


 


2439-2458
10306
GGUGGAGUUCGGGGCCGGA
12306
GGUGGAGUUCGGGGCCGGAdTsdT
antis


 


2443-2462
10307
GCCCCGAACUCCACCAGAG
12307
GccccGAAcuccAccAGAGdTsdT
sense


 


2443-2462
10308
CUCUGGUGGAGUUCGGGGC
12308
CUCUGGUGGAGUUCGGGGCdTsdT
antis


 


2444-2463
10309
CCCCGAACUCCACCAGAGG
12309
ccccGAAcuccAccAGAGGdTsdT
sense


 


2444-2463
10310
CCUCUGGUGGAGUUCGGGG
12310
CCUCUGGUGGAGUUCGGGGdTsdT
antis


 


2446-2465
10311
CCGAACUCCACCAGAGGCA
12311
ccGAAcuccAccAGAGGcAdTsdT
sense


 


2446-2465
10312
UGCCUCUGGUGGAGUUCGG
12312
UGCCUCUGGUGGAGUUCGGdTsdT
antis


 


2447-2466
10313
CGAACUCCACCAGAGGCAA
12313
cGAAcuccAccAGAGGcAAdTsdT
sense


 


2447-2466
10314
UUGCCUCUGGUGGAGUUCG
12314
UUGCCUCUGGUGGAGUUCGdTsdT
antis


 


2448-2467
10315
GAACUCCACCAGAGGCAAU
12315
GAAcuccAccAGAGGcAAudTsdT
sense


 


2448-2467
10316
AUUGCCUCUGGUGGAGUUC
12316
AUUGCCUCUGGUGGAGUUCdTsdT
antis


 


2458-2477
10317
AGAGGCAAUUGCACUGUGC
12317
AGAGGcAAuuGcAcuGuGcdTsdT
sense


 


2458-2477
10318
GCACAGUGCAAUUGCCUCU
12318
GcAcAGUGcAAUUGCCUCUdTsdT
antis


 


2459-2478
10319
GAGGCAAUUGCACUGUGCA
12319
GAGGcAAuuGcAcuGuGcAdTsdT
sense


 


2459-2478
10320
UGCACAGUGCAAUUGCCUC
12320
UGcAcAGUGcAAUUGCCUCdTsdT
antis


 


2461-2480
10321
GGCAAUUGCACUGUGCAGC
12321
GGcAAuuGcAcuGuGcAGcdTsdT
sense


 


2461-2480
10322
GCUGCACAGUGCAAUUGCC
12322
GCUGcAcAGUGcAAUUGCCdTsdT
antis


 


2462-2481
10323
GCAAUUGCACUGUGCAGCC
12323
GcAAuuGcAcuGuGcAGccdTsdT
sense


 


2462-2481
10324
GGCUGCACAGUGCAAUUGC
12324
GGCUGcAcAGUGcAAUUGCdTsdT
antis


 


2464-2483
10325
AAUUGCACUGUGCAGCCGU
12325
AAuuGcAcuGuGcAGccGudTsdT
sense


 


2464-2483
10326
ACGGCUGCACAGUGCAAUU
12326
ACGGCUGcAcAGUGcAAUUdTsdT
antis


 


2465-2484
10327
AUUGCACUGUGCAGCCGUC
12327
AuuGcAcuGuGcAGccGucdTsdT
sense


 


2465-2484
10328
GACGGCUGCACAGUGCAAU
12328
GACGGCUGcAcAGUGcAAUdTsdT
antis


 


2471-2490
10329
CUGUGCAGCCGUCUGCUGG
12329
cuGuGcAGccGucuGcuGGdTsdT
sense


 


2471-2490
10330
CCAGCAGACGGCUGCACAG
12330
CcAGcAGACGGCUGcAcAGdTsdT
antis


 


2485-2504
10331
GCUGGAGUACACACCUACC
12331
GcuGGAGuAcAcAccuAccdTsdT
sense


 


2485-2504
10332
GGUAGGUGUGUACUCCAGC
12332
GGuAGGUGUGuACUCcAGCdTsdT
antis


 


2507-2526
10333
CGGCUAACACCACUGGAAG
12333
cGGcuAAcAccAcuGGAAGdTsdT
sense


 


2507-2526
10334
CUUCCAGUGGUGUUAGCCG
12334
CUUCcAGUGGUGUuAGCCGdTsdT
antis


 


2509-2528
10335
GCUAACACCACUGGAAGCU
12335
GcuAAcAccAcuGGAAGcudTsdT
sense


 


2509-2528
10336
AGCUUCCAGUGGUGUUAGC
12336
AGCUUCcAGUGGUGUuAGCdTsdT
antis


 


2510-2529
10337
CUAACACCACUGGAAGCUU
12337
cuAAcAccAcuGGAAGcuudTsdT
sense


 


2510-2529
10338
AAGCUUCCAGUGGUGUUAG
12338
AAGCUUCcAGUGGUGUuAGdTsdT
antis


 


2512-2531
10339
AACACCACUGGAAGCUUGU
12339
AAcAccAcuGGAAGcuuGudTsdT
sense


 


2512-2531
10340
ACAAGCUUCCAGUGGUGUU
12340
AcAAGCUUCcAGUGGUGUUdTsdT
antis


 


2513-2532
10341
ACACCACUGGAAGCUUGUG
12341
AcAccAcuGGAAGcuuGuGdTsdT
sense


 


2513-2532
10342
CACAAGCUUCCAGUGGUGU
12342
cAcAAGCUUCcAGUGGUGUdTsdT
antis


 


2514-2533
10343
CACCACUGGAAGCUUGUGC
12343
cAccAcuGGAAGcuuGuGcdTsdT
sense


 


2514-2533
10344
GCACAAGCUUCCAGUGGUG
12344
GcAcAAGCUUCcAGUGGUGdTsdT
antis


 


2515-2534
10345
ACCACUGGAAGCUUGUGCA
12345
AccAcuGGAAGcuuGuGcAdTsdT
sense


 


2515-2534
10346
UGCACAAGCUUCCAGUGGU
12346
UGcAcAAGCUUCcAGUGGUdTsdT
antis


 


2517-2536
10347
CACUGGAAGCUUGUGCACA
12347
cAcuGGAAGcuuGuGcAcAdTsdT
sense


 


2517-2536
10348
UGUGCACAAGCUUCCAGUG
12348
UGUGcAcAAGCUUCcAGUGdTsdT
antis


 


2519-2538
10349
CUGGAAGCUUGUGCACAUU
12349
cuGGAAGcuuGuGcAcAuudTsdT
sense


 


2519-2538
10350
AAUGUGCACAAGCUUCCAG
12350
AAUGUGcAcAAGCUUCcAGdTsdT
antis


 


2520-2539
10351
UGGAAGCUUGUGCACAUUC
12351
uGGAAGcuuGuGcAcAuucdTsdT
sense


 


2520-2539
10352
GAAUGUGCACAAGCUUCCA
12352
GAAUGUGcAcAAGCUUCcAdTsdT
antis


 


2521-2540
10353
GGAAGCUUGUGCACAUUCA
12353
GGAAGcuuGuGcAcAuucAdTsdT
sense


 


2521-2540
10354
UGAAUGUGCACAAGCUUCC
12354
UGAAUGUGcAcAAGCUUCCdTsdT
antis


 


2522-2541
10355
GAAGCUUGUGCACAUUCAU
12355
GAAGcuuGuGcAcAuucAudTsdT
sense


 


2522-2541
10356
AUGAAUGUGCACAAGCUUC
12356
AUGAAUGUGcAcAAGCUUCdTsdT
antis


 


2524-2543
10357
AGCUUGUGCACAUUCAUUU
12357
AGcuuGuGcAcAuucAuuudTsdT
sense


 


2524-2543
10358
AAAUGAAUGUGCACAAGCU
12358
AAAUGAAUGUGcAcAAGCUdTsdT
antis


 


1560-1579
10359
AGAGCUGCAAGCCAGUGCA
12359
AGAGcuGcAAGccAGuGcAdTsdT
sense


 


1560-1579
10360
UGCACUGGCUUGCAGCUCU
12360
UGcACUGGCUUGcAGCUCUdTsdT
antis


 


1561-1580
10361
GAGCUGCAAGCCAGUGCAG
12361
GAGcuGcAAGccAGuGcAGdTsdT
sense


 


1561-1580
10362
CUGCACUGGCUUGCAGCUC
12362
CUGcACUGGCUUGcAGCUCdTsdT
antis


 


1575-1594
10363
UGCAGCAGCCUUCAGCUUU
12363
uGcAGcAGccuucAGcuuudTsdT
sense


 


1575-1594
10364
AAAGCUGAAGGCUGCUGCA
12364
AAAGCUGAAGGCUGCUGcAdTsdT
antis


 


1611-1630
10365
GCAGAGAUAAAGAUGGCAG
12365
GcAGAGAuAAAGAuGGcAGdTsdT
sense


 


1611-1630
10366
CUGCCAUCUUUAUCUCUGC
12366
CUGCcAUCUUuAUCUCUGCdTsdT
antis


 


1661-1680
10367
CAGGGUCCUGACAGGCCAC
12367
cAGGGuccuGAcAGGccAcdTsdT
sense


 


1661-1680
10368
GUGGCCUGUCAGGACCCUG
12368
GUGGCCUGUcAGGACCCUGdTsdT
antis


 


1779-1798
10369
AGAAAGUUCUACAGGACAA
12369
AGAAAGuucuAcAGGAcAAdTsdT
sense


 


1779-1798
10370
UUGUCCUGUAGAACUUUCU
12370
UUGUCCUGuAGAACUUUCUdTsdT
antis


 


1917-1936
10371
UGCUGGACUAUGUUCCGGA
12371
uGcuGGAcuAuGuuccGGAdTsdT
sense


 


1917-1936
10372
UCCGGAACAUAGUCCAGCA
12372
UCCGGAAcAuAGUCcAGcAdTsdT
antis


 


2012-2031
10373
UAUCAGCUGUUCAGAAGUC
12373
uAucAGcuGuucAGAAGucdTsdT
sense


 


2012-2031
10374
GACUUCUGAACAGCUGAUA
12374
GACUUCUGAAcAGCUGAuAdTsdT
antis


 


2042-2061
10375
CAUUCCUUUGGAAUCUGCC
12375
cAuuccuuuGGAAucuGccdTsdT
sense


 


2042-2061
10376
GGCAGAUUCCAAAGGAAUG
12376
GGcAGAUUCcAAAGGAAUGdTsdT
antis


 


2053-2072
10377
AAUCUGCCAUCGAGACAUU
12377
AAucuGccAucGAGAcAuudTsdT
sense


 


2053-2072
10378
AAUGUCUCGAUGGCAGAUU
12378
AAUGUCUCGAUGGcAGAUUdTsdT
antis


 


2066-2085
10379
GACAUUAAACCACAGAACC
12379
GAcAuuAAAccAcAGAAccdTsdT
sense


 


2066-2085
10380
GGUUCUGUGGUUUAAUGUC
12380
GGUUCUGUGGUUuAAUGUCdTsdT
antis


 


2149-2168
10381
CCGAGGAGAGCCCAAUGUU
12381
ccGAGGAGAGcccAAuGuudTsdT
sense


 


2149-2168
10382
AACAUUGGGCUCUCCUCGG
12382
AAcAUUGGGCUCUCCUCGGdTsdT
antis


 


2248-2267
10383
GUCUGCAGGCUGUGUGUUG
12383
GucuGcAGGcuGuGuGuuGdTsdT
sense


 


2248-2267
10384
CAACACACAGCCUGCAGAC
12384
cAAcAcAcAGCCUGcAGACdTsdT
antis


 


2302-2321
10385
GGACAGUGGUGUGGAUCAG
12385
GGAcAGuGGuGuGGAucAGdTsdT
sense


 


2302-2321
10386
CUGAUCCACACCACUGUCC
12386
CUGAUCcAcACcACUGUCCdTsdT
antis


 


2330-2349
10387
AUAAUAAAGGUCCUAGGAA
12387
AuAAuAAAGGuccuAGGAAdTsdT
sense


 


2330-2349
10388
UUCCUAGGACCUUUAUUAU
12388
UUCCuAGGACCUUuAUuAUdTsdT
antis


 


2362-2381
10389
GCAAAUUAGAGAAAUGAAC
12389
GcAAAuuAGAGAAAuGAAcdTsdT
sense


 


2362-2381
10390
GUUCAUUUCUCUAAUUUGC
12390
GUUcAUUUCUCuAAUUUGCdTsdT
antis


 


2366-2385
10391
AUUAGAGAAAUGAACCCAA
12391
AuuAGAGAAAuGAAcccAAdTsdT
sense


 


2366-2385
10392
UUGGGUUCAUUUCUCUAAU
12392
UUGGGUUcAUUUCUCuAAUdTsdT
antis


 


2378-2397
10393
AACCCAAAUUAUACAGAAU
12393
AAcccAAAuuAuAcAGAAudTsdT
sense


 


2378-2397
10394
AUUCUGUAUAAUUUGGGUU
12394
AUUCUGuAuAAUUUGGGUUdTsdT
antis


 


2432-2451
10395
AAGGUCUUCCGGCCCCGAA
12395
AAGGucuuccGGccccGAAdTsdT
sense


 


2432-2451
10396
UUCGGGGCCGGAAGACCUU
12396
UUCGGGGCCGGAAGACCUUdTsdT
antis


 


2441-2460
10397
CGGCCCCGAACUCCACCAG
12397
cGGccccGAAcuccAccAGdTsdT
sense


 


2441-2460
10398
CUGGUGGAGUUCGGGGCCG
12398
CUGGUGGAGUUCGGGGCCGdTsdT
antis


 


2456-2475
10399
CCAGAGGCAAUUGCACUGU
12399
ccAGAGGcAAuuGcAcuGudTsdT
sense


 


2456-2475
10400
ACAGUGCAAUUGCCUCUGG
12400
AcAGUGcAAUUGCCUCUGGdTsdT
antis


 


2472-2491
10401
UGUGCAGCCGUCUGCUGGA
12401
uGuGcAGccGucuGcuGGAdTsdT
sense


 


2472-2491
10402
UCCAGCAGACGGCUGCACA
12402
UCcAGcAGACGGCUGcAcAdTsdT
antis


 


1538-1557
10403
CCGAGAACCACCUCCUUUG
12403
ccGAGAAccAccuccuuuGdTsdT
sense


 


1538-1557
10404
CAAAGGAGGUGGUUCUCGG
12404
cAAAGGAGGUGGUUCUCGGdTsdT
antis


 


1539-1558
10405
CGAGAACCACCUCCUUUGC
12405
cGAGAAccAccuccuuuGcdTsdT
sense


 


1539-1558
10406
GCAAAGGAGGUGGUUCUCG
12406
GcAAAGGAGGUGGUUCUCGdTsdT
antis


 


1547-1566
10407
ACCUCCUUUGCGGAGAGCU
12407
AccuccuuuGcGGAGAGcudTsdT
sense


 


1547-1566
10408
AGCUCUCCGCAAAGGAGGU
12408
AGCUCUCCGcAAAGGAGGUdTsdT
antis


 


1551-1570
10409
CCUUUGCGGAGAGCUGCAA
12409
ccuuuGcGGAGAGcuGcAAdTsdT
sense


 


1551-1570
10410
UUGCAGCUCUCCGCAAAGG
12410
UUGcAGCUCUCCGcAAAGGdTsdT
antis


 


1558-1577
10411
GGAGAGCUGCAAGCCAGUG
12411
GGAGAGcuGcAAGccAGuGdTsdT
sense


 


1558-1577
10412
CACUGGCUUGCAGCUCUCC
12412
cACUGGCUUGcAGCUCUCCdTsdT
antis


 


1573-1592
10413
AGUGCAGCAGCCUUCAGCU
12413
AGuGcAGcAGccuucAGcudTsdT
sense


 


1573-1592
10414
AGCUGAAGGCUGCUGCACU
12414
AGCUGAAGGCUGCUGcACUdTsdT
antis


 


1574-1593
10415
GUGCAGCAGCCUUCAGCUU
12415
GuGcAGcAGccuucAGcuudTsdT
sense


 


1574-1593
10416
AAGCUGAAGGCUGCUGCAC
12416
AAGCUGAAGGCUGCUGcACdTsdT
antis


 


1584-1603
10417
CUUCAGCUUUUGGUAGCAU
12417
cuucAGcuuuuGGuAGcAudTsdT
sense


 


1584-1603
10418
AUGCUACCAAAAGCUGAAG
12418
AUGCuACcAAAAGCUGAAGdTsdT
antis


 


1594-1613
10419
UGGUAGCAUGAAAGUUAGC
12419
uGGuAGcAuGAAAGuuAGcdTsdT
sense


 


1594-1613
10420
GCUAACUUUCAUGCUACCA
12420
GCuAACUUUcAUGCuACcAdTsdT
antis


 


1599-1618
10421
GCAUGAAAGUUAGCAGAGA
12421
GcAuGAAAGuuAGcAGAGAdTsdT
sense


 


1599-1618
10422
UCUCUGCUAACUUUCAUGC
12422
UCUCUGCuAACUUUcAUGCdTsdT
antis


 


1600-1619
10423
CAUGAAAGUUAGCAGAGAU
12423
cAuGAAAGuuAGcAGAGAudTsdT
sense


 


1600-1619
10424
AUCUCUGCUAACUUUCAUG
12424
AUCUCUGCuAACUUUcAUGdTsdT
antis


 


1613-1632
10425
AGAGAUAAAGAUGGCAGCA
12425
AGAGAuAAAGAuGGcAGcAdTsdT
sense


 


1613-1632
10426
UGCUGCCAUCUUUAUCUCU
12426
UGCUGCcAUCUUuAUCUCUdTsdT
antis


 


1614-1633
10427
GAGAUAAAGAUGGCAGCAA
12427
GAGAuAAAGAuGGcAGcAAdTsdT
sense


 


1614-1633
10428
UUGCUGCCAUCUUUAUCUC
12428
UUGCUGCcAUCUUuAUCUCdTsdT
antis


 


1630-1649
10429
CAAGGUAACCACAGUAGUG
12429
cAAGGuAAccAcAGuAGuGdTsdT
sense


 


1630-1649
10430
CACUACUGUGGUUACCUUG
12430
cACuACUGUGGUuACCUUGdTsdT
antis


 


1650-1669
10431
CAACUCCUGGCCAGGGUCC
12431
cAAcuccuGGccAGGGuccdTsdT
sense


 


1650-1669
10432
GGACCCUGGCCAGGAGUUG
12432
GGACCCUGGCcAGGAGUUGdTsdT
antis


 


1652-1671
10433
ACUCCUGGCCAGGGUCCUG
12433
AcuccuGGccAGGGuccuGdTsdT
sense


 


1652-1671
10434
CAGGACCCUGGCCAGGAGU
12434
cAGGACCCUGGCcAGGAGUdTsdT
antis


 


1653-1672
10435
CUCCUGGCCAGGGUCCUGA
12435
cuccuGGccAGGGuccuGAdTsdT
sense


 


1653-1672
10436
UCAGGACCCUGGCCAGGAG
12436
UcAGGACCCUGGCcAGGAGdTsdT
antis


 


1654-1673
10437
UCCUGGCCAGGGUCCUGAC
12437
uccuGGccAGGGuccuGAcdTsdT
sense


 


1654-1673
10438
GUCAGGACCCUGGCCAGGA
12438
GUcAGGACCCUGGCcAGGAdTsdT
antis


 


1665-1684
10439
GUCCUGACAGGCCACAGGA
12439
GuccuGAcAGGccAcAGGAdTsdT
sense


 


1665-1684
10440
UCCUGUGGCCUGUCAGGAC
12440
UCCUGUGGCCUGUcAGGACdTsdT
antis


 


1673-1692
10441
AGGCCACAGGAAGUCAGUU
12441
AGGccAcAGGAAGucAGuudTsdT
sense


 


1673-1692
10442
AACUGACUUCCUGUGGCCU
12442
AACUGACUUCCUGUGGCCUdTsdT
antis


 


1688-1707
10443
AGUUAUACAGACACGAAAG
12443
AGuuAuAcAGAcAcGAAAGdTsdT
sense


 


1688-1707
10444
CUUUCGUGUCUGUAUAACU
12444
CUUUCGUGUCUGuAuAACUdTsdT
antis


 


1743-1762
10445
CCAAACUUUGUGAUUCUGG
12445
ccAAAcuuuGuGAuucuGGdTsdT
sense


 


1743-1762
10446
CCAGAAUCACAAAGUUUGG
12446
CcAGAAUcAcAAAGUUUGGdTsdT
antis


 


1744-1763
10447
CAAACUUUGUGAUUCUGGA
12447
cAAAcuuuGuGAuucuGGAdTsdT
sense


 


1744-1763
10448
UCCAGAAUCACAAAGUUUG
12448
UCcAGAAUcAcAAAGUUUGdTsdT
antis


 


1745-1764
10449
AAACUUUGUGAUUCUGGAG
12449
AAAcuuuGuGAuucuGGAGdTsdT
sense


 


1745-1764
10450
CUCCAGAAUCACAAAGUUU
12450
CUCcAGAAUcAcAAAGUUUdTsdT
antis


 


1746-1765
10451
AACUUUGUGAUUCUGGAGA
12451
AAcuuuGuGAuucuGGAGAdTsdT
sense


 


1746-1765
10452
UCUCCAGAAUCACAAAGUU
12452
UCUCcAGAAUcAcAAAGUUdTsdT
antis


 


1780-1799
10453
GAAAGUUCUACAGGACAAG
12453
GAAAGuucuAcAGGAcAAGdTsdT
sense


 


1780-1799
10454
CUUGUCCUGUAGAACUUUC
12454
CUUGUCCUGuAGAACUUUCdTsdT
antis


 


1781-1800
10455
AAAGUUCUACAGGACAAGC
12455
AAAGuucuAcAGGAcAAGcdTsdT
sense


 


1781-1800
10456
GCUUGUCCUGUAGAACUUU
12456
GCUUGUCCUGuAGAACUUUdTsdT
antis


 


1782-1801
10457
AAGUUCUACAGGACAAGCG
12457
AAGuucuAcAGGAcAAGcGdTsdT
sense


 


1782-1801
10458
CGCUUGUCCUGUAGAACUU
12458
CGCUUGUCCUGuAGAACUUdTsdT
antis


 


1809-1828
10459
ACCGAGAGCUCCAGAUCAU
12459
AccGAGAGcuccAGAucAudTsdT
sense


 


1809-1828
10460
AUGAUCUGGAGCUCUCGGU
12460
AUGAUCUGGAGCUCUCGGUdTsdT
antis


 


1880-1899
10461
AGUGGUGAGAAGAAAGAUG
12461
AGuGGuGAGAAGAAAGAuGdTsdT
sense


 


1880-1899
10462
CAUCUUUCUUCUCACCACU
12462
cAUCUUUCUUCUcACcACUdTsdT
antis


 


1885-1904
10463
UGAGAAGAAAGAUGAGGUC
12463
uGAGAAGAAAGAuGAGGucdTsdT
sense


 


1885-1904
10464
GACCUCAUCUUUCUUCUCA
12464
GACCUcAUCUUUCUUCUcAdTsdT
antis


 


1889-1908
10465
AAGAAAGAUGAGGUCUACC
12465
AAGAAAGAuGAGGucuAccdTsdT
sense


 


1889-1908
10466
GGUAGACCUCAUCUUUCUU
12466
GGuAGACCUcAUCUUUCUUdTsdT
antis


 


2043-2062
10467
AUUCCUUUGGAAUCUGCCA
12467
AuuccuuuGGAAucuGccAdTsdT
sense


 


2043-2062
10468
UGGCAGAUUCCAAAGGAAU
12468
UGGcAGAUUCcAAAGGAAUdTsdT
antis


 


2050-2069
10469
UGGAAUCUGCCAUCGAGAC
12469
uGGAAucuGccAucGAGAcdTsdT
sense


 


2050-2069
10470
GUCUCGAUGGCAGAUUCCA
12470
GUCUCGAUGGcAGAUUCcAdTsdT
antis


 


2092-2111
10471
GGAUCCUGAUACAGCUGUA
12471
GGAuccuGAuAcAGcuGuAdTsdT
sense


 


2092-2111
10472
UACAGCUGUAUCAGGAUCC
12472
uAcAGCUGuAUcAGGAUCCdTsdT
antis


 


2116-2135
10473
ACUCUGUGACUUUGGAAGU
12473
AcucuGuGAcuuuGGAAGudTsdT
sense


 


2116-2135
10474
ACUUCCAAAGUCACAGAGU
12474
ACUUCcAAAGUcAcAGAGUdTsdT
antis


 


2143-2162
10475
GCUGGUCCGAGGAGAGCCC
12475
GcuGGuccGAGGAGAGcccdTsdT
sense


 


2143-2162
10476
GGGCUCUCCUCGGACCAGC
12476
GGGCUCUCCUCGGACcAGCdTsdT
antis


 


2159-2178
10477
CCCAAUGUUUCAUAUAUCU
12477
cccAAuGuuucAuAuAucudTsdT
sense


 


2159-2178
10478
AGAUAUAUGAAACAUUGGG
12478
AGAuAuAUGAAAcAUUGGGdTsdT
antis


 


2163-2182
10479
AUGUUUCAUAUAUCUGUUC
12479
AuGuuucAuAuAucuGuucdTsdT
sense


 


2163-2182
10480
GAACAGAUAUAUGAAACAU
12480
GAAcAGAuAuAUGAAAcAUdTsdT
antis


 


2207-2226
10481
AUCUUUGGAGCCACUGAUU
12481
AucuuuGGAGccAcuGAuudTsdT
sense


 


2207-2226
10482
AAUCAGUGGCUCCAAAGAU
12482
AAUcAGUGGCUCcAAAGAUdTsdT
antis


 


2247-2266
10483
GGUCUGCAGGCUGUGUGUU
12483
GGucuGcAGGcuGuGuGuudTsdT
sense


 


2247-2266
10484
AACACACAGCCUGCAGACC
12484
AAcAcAcAGCCUGcAGACCdTsdT
antis


 


2251-2270
10485
UGCAGGCUGUGUGUUGGCU
12485
uGcAGGcuGuGuGuuGGcudTsdT
sense


 


2251-2270
10486
AGCCAACACACAGCCUGCA
12486
AGCcAAcAcAcAGCCUGcAdTsdT
antis


 


2261-2280
10487
GUGUUGGCUGAAUUGUUGC
12487
GuGuuGGcuGAAuuGuuGcdTsdT
sense


 


2261-2280
10488
GCAACAAUUCAGCCAACAC
12488
GcAAcAAUUcAGCcAAcACdTsdT
antis


 


2298-2317
10489
CUGGGGACAGUGGUGUGGA
12489
cuGGGGAcAGuGGuGuGGAdTsdT
sense


 


2298-2317
10490
UCCACACCACUGUCCCCAG
12490
UCcAcACcACUGUCCCcAGdTsdT
antis


 


2300-2319
10491
GGGGACAGUGGUGUGGAUC
12491
GGGGAcAGuGGuGuGGAucdTsdT
sense


 


2300-2319
10492
GAUCCACACCACUGUCCCC
12492
GAUCcAcACcACUGUCCCCdTsdT
antis


 


2301-2320
10493
GGGACAGUGGUGUGGAUCA
12493
GGGAcAGuGGuGuGGAucAdTsdT
sense


 


2301-2320
10494
UGAUCCACACCACUGUCCC
12494
UGAUCcAcACcACUGUCCCdTsdT
antis


 


2319-2338
10495
AGUUGGUGGAAAUAAUAAA
12495
AGuuGGuGGAAAuAAuAAAdTsdT
sense


 


2319-2338
10496
UUUAUUAUUUCCACCAACU
12496
UUuAUuAUUUCcACcAACUdTsdT
antis


 


2323-2342
10497
GGUGGAAAUAAUAAAGGUC
12497
GGuGGAAAuAAuAAAGGucdTsdT
sense


 


2323-2342
10498
GACCUUUAUUAUUUCCACC
12498
GACCUUuAUuAUUUCcACCdTsdT
antis


 


2325-2344
10499
UGGAAAUAAUAAAGGUCCU
12499
uGGAAAuAAuAAAGGuccudTsdT
sense


 


2325-2344
10500
AGGACCUUUAUUAUUUCCA
12500
AGGACCUUuAUuAUUUCcAdTsdT
antis


 


2363-2382
10501
CAAAUUAGAGAAAUGAACC
12501
cAAAuuAGAGAAAuGAAccdTsdT
sense


 


2363-2382
10502
GGUUCAUUUCUCUAAUUUG
12502
GGUUcAUUUCUCuAAUUUGdTsdT
antis


 


2376-2395
10503
UGAACCCAAAUUAUACAGA
12503
uGAAcccAAAuuAuAcAGAdTsdT
sense


 


2376-2395
10504
UCUGUAUAAUUUGGGUUCA
12504
UCUGuAuAAUUUGGGUUcAdTsdT
antis


 


2377-2396
10505
GAACCCAAAUUAUACAGAA
12505
GAAcccAAAuuAuAcAGAAdTsdT
sense


 


2377-2396
10506
UUCUGUAUAAUUUGGGUUC
12506
UUCUGuAuAAUUUGGGUUCdTsdT
antis


 


2383-2402
10507
AAAUUAUACAGAAUUCAAA
12507
AAAuuAuAcAGAAuucAAAdTsdT
sense


 


2383-2402
10508
UUUGAAUUCUGUAUAAUUU
12508
UUUGAAUUCUGuAuAAUUUdTsdT
antis


 


2391-2410
10509
CAGAAUUCAAAUUCCCUCA
12509
cAGAAuucAAAuucccucAdTsdT
sense


 


2391-2410
10510
UGAGGGAAUUUGAAUUCUG
12510
UGAGGGAAUUUGAAUUCUGdTsdT
antis


 


2394-2413
10511
AAUUCAAAUUCCCUCAAAU
12511
AAuucAAAuucccucAAAudTsdT
sense


 


2394-2413
10512
AUUUGAGGGAAUUUGAAUU
12512
AUUUGAGGGAAUUUGAAUUdTsdT
antis


 


2436-2455
10513
UCUUCCGGCCCCGAACUCC
12513
ucuuccGGccccGAAcuccdTsdT
sense


 


2436-2455
10514
GGAGUUCGGGGCCGGAAGA
12514
GGAGUUCGGGGCCGGAAGAdTsdT
antis


 


2442-2461
10515
GGCCCCGAACUCCACCAGA
12515
GGccccGAAcuccAccAGAdTsdT
sense


 


2442-2461
10516
UCUGGUGGAGUUCGGGGCC
12516
UCUGGUGGAGUUCGGGGCCdTsdT
antis


 


2449-2468
10517
AACUCCACCAGAGGCAAUU
12517
AAcuccAccAGAGGcAAuudTsdT
sense


 


2449-2468
10518
AAUUGCCUCUGGUGGAGUU
12518
AAUUGCCUCUGGUGGAGUUdTsdT
antis


 


2450-2469
10519
ACUCCACCAGAGGCAAUUG
12519
AcuccAccAGAGGcAAuuGdTsdT
sense


 


2450-2469
10520
CAAUUGCCUCUGGUGGAGU
12520
cAAUUGCCUCUGGUGGAGUdTsdT
antis


 


2457-2476
10521
CAGAGGCAAUUGCACUGUG
12521
cAGAGGcAAuuGcAcuGuGdTsdT
sense


 


2457-2476
10522
CACAGUGCAAUUGCCUCUG
12522
cAcAGUGcAAUUGCCUCUGdTsdT
antis


 


2470-2489
10523
ACUGUGCAGCCGUCUGCUG
12523
AcuGuGcAGccGucuGcuGdTsdT
sense


 


2470-2489
10524
CAGCAGACGGCUGCACAGU
12524
cAGcAGACGGCUGcAcAGUdTsdT
antis


 


2473-2492
10525
GUGCAGCCGUCUGCUGGAG
12525
GuGcAGccGucuGcuGGAGdTsdT
sense


 


2473-2492
10526
CUCCAGCAGACGGCUGCAC
12526
CUCcAGcAGACGGCUGcACdTsdT
antis


 


2475-2494
10527
GCAGCCGUCUGCUGGAGUA
12527
GcAGccGucuGcuGGAGuAdTsdT
sense


 


2475-2494
10528
UACUCCAGCAGACGGCUGC
12528
uACUCcAGcAGACGGCUGCdTsdT
antis


 


1612-1631
10529
CAGAGAUAAAGAUGGCAGC
12529
cAGAGAuAAAGAuGGcAGcdTsdT
sense


 


1612-1631
10530
GCUGCCAUCUUUAUCUCUG
12530
GCUGCcAUCUUuAUCUCUGdTsdT
antis


 


1804-1823
10531
UAAGAACCGAGAGCUCCAG
12531
uAAGAAccGAGAGcuccAGdTsdT
sense


 


1804-1823
10532
CUGGAGCUCUCGGUUCUUA
12532
CUGGAGCUCUCGGUUCUuAdTsdT
antis


 


1805-1824
10533
AAGAACCGAGAGCUCCAGA
12533
AAGAAccGAGAGcuccAGAdTsdT
sense


 


1805-1824
10534
UCUGGAGCUCUCGGUUCUU
12534
UCUGGAGCUCUCGGUUCUUdTsdT
antis


 


1888-1907
10535
GAAGAAAGAUGAGGUCUAC
12535
GAAGAAAGAuGAGGucuAcdTsdT
sense


 


1888-1907
10536
GUAGACCUCAUCUUUCUUC
12536
GuAGACCUcAUCUUUCUUCdTsdT
antis


 


2165-2184
10537
GUUUCAUAUAUCUGUUCUC
12537
GuuucAuAuAucuGuucucdTsdT
sense


 


2165-2184
10538
GAGAACAGAUAUAUGAAAC
12538
GAGAAcAGAuAuAUGAAACdTsdT
antis


 


2332-2351
10539
AAUAAAGGUCCUAGGAACA
12539
AAuAAAGGuccuAGGAAcAdTsdT
sense


 


2332-2351
10540
UGUUCCUAGGACCUUUAUU
12540
UGUUCCuAGGACCUUuAUUdTsdT
antis


 


2518-2537
10541
ACUGGAAGCUUGUGCACAU
12541
AcuGGAAGcuuGuGcAcAudTsdT
sense


 


2518-2537
10542
AUGUGCACAAGCUUCCAGU
12542
AUGUGcAcAAGCUUCcAGUdTsdT
antis


 


1565-1584
10543
UGCAAGCCAGUGCAGCAGC
12543
uGcAAGccAGuGcAGcAGcdTsdT
sense


 


1565-1584
10544
GCUGCUGCACUGGCUUGCA
12544
GCUGCUGcACUGGCUUGcAdTsdT
antis


 


1569-1588
10545
AGCCAGUGCAGCAGCCUUC
12545
AGccAGuGcAGcAGccuucdTsdT
sense


 


1569-1588
10546
GAAGGCUGCUGCACUGGCU
12546
GAAGGCUGCUGcACUGGCUdTsdT
antis


 


1631-1650
10547
AAGGUAACCACAGUAGUGG
12547
AAGGuAAccAcAGuAGuGGdTsdT
sense


 


1631-1650
10548
CCACUACUGUGGUUACCUU
12548
CcACuACUGUGGUuACCUUdTsdT
antis


 


1659-1678
10549
GCCAGGGUCCUGACAGGCC
12549
GccAGGGuccuGAcAGGccdTsdT
sense


 


1659-1678
10550
GGCCUGUCAGGACCCUGGC
12550
GGCCUGUcAGGACCCUGGCdTsdT
antis


 


1711-1730
10551
UGGAAAUGGAUCAUUUGGU
12551
uGGAAAuGGAucAuuuGGudTsdT
sense


 


1711-1730
10552
ACCAAAUGAUCCAUUUCCA
12552
ACcAAAUGAUCcAUUUCcAdTsdT
antis


 


1756-1775
10553
UUCUGGAGAACUGGUUGCC
12553
uucuGGAGAAcuGGuuGccdTsdT
sense


 


1756-1775
10554
GGCAACCAGUUCUCCAGAA
12554
GGcAACcAGUUCUCcAGAAdTsdT
antis


 


1761-1780
10555
GAGAACUGGUUGCCAUCAA
12555
GAGAAcuGGuuGccAucAAdTsdT
sense


 


1761-1780
10556
UUGAUGGCAACCAGUUCUC
12556
UUGAUGGcAACcAGUUCUCdTsdT
antis


 


1762-1781
10557
AGAACUGGUUGCCAUCAAG
12557
AGAAcuGGuuGccAucAAGdTsdT
sense


 


1762-1781
10558
CUUGAUGGCAACCAGUUCU
12558
CUUGAUGGcAACcAGUUCUdTsdT
antis


 


1997-2016
10559
GUCAAGUUGUAUAUGUAUC
12559
GucAAGuuGuAuAuGuAucdTsdT
sense


 


1997-2016
10560
GAUACAUAUACAACUUGAC
12560
GAuAcAuAuAcAACUUGACdTsdT
antis


 


2040-2059
10561
UCCAUUCCUUUGGAAUCUG
12561
uccAuuccuuuGGAAucuGdTsdT
sense


 


2040-2059
10562
CAGAUUCCAAAGGAAUGGA
12562
cAGAUUCcAAAGGAAUGGAdTsdT
antis


 


2133-2152
10563
GUGCAAAGCAGCUGGUCCG
12563
GuGcAAAGcAGcuGGuccGdTsdT
sense


 


2133-2152
10564
CGGACCAGCUGCUUUGCAC
12564
CGGACcAGCUGCUUUGcACdTsdT
antis


 


2186-2205
10565
UACUACAGGGCACCAGAGU
12565
uAcuAcAGGGcAccAGAGudTsdT
sense


 


2186-2205
10566
ACUCUGGUGCCCUGUAGUA
12566
ACUCUGGUGCCCUGuAGuAdTsdT
antis


 


2250-2269
10567
CUGCAGGCUGUGUGUUGGC
12567
cuGcAGGcuGuGuGuuGGcdTsdT
sense


 


2250-2269
10568
GCCAACACACAGCCUGCAG
12568
GCcAAcAcAcAGCCUGcAGdTsdT
antis


 


2466-2485
10569
UUGCACUGUGCAGCCGUCU
12569
uuGcAcuGuGcAGccGucudTsdT
sense


 


2466-2485
10570
AGACGGCUGCACAGUGCAA
12570
AGACGGCUGcAcAGUGcAAdTsdT
antis


 


2523-2542
10571
AAGCUUGUGCACAUUCAUU
12571
AAGcuuGuGcAcAuucAuudTsdT
sense


 


2523-2542
10572
AAUGAAUGUGCACAAGCUU
12572
AAUGAAUGUGcAcAAGCUUdTsdT
antis


 


1548-1567
10573
CCUCCUUUGCGGAGAGCUG
12573
ccuccuuuGcGGAGAGcuGdTsdT
sense


 


1548-1567
10574
CAGCUCUCCGCAAAGGAGG
12574
cAGCUCUCCGcAAAGGAGGdTsdT
antis


 


1566-1585
10575
GCAAGCCAGUGCAGCAGCC
12575
GcAAGccAGuGcAGcAGccdTsdT
sense


 


1566-1585
10576
GGCUGCUGCACUGGCUUGC
12576
GGCUGCUGcACUGGCUUGCdTsdT
antis


 


1656-1675
10577
CUGGCCAGGGUCCUGACAG
12577
cuGGccAGGGuccuGAcAGdTsdT
sense


 


1656-1675
10578
CUGUCAGGACCCUGGCCAG
12578
CUGUcAGGACCCUGGCcAGdTsdT
antis


 


1763-1782
10579
GAACUGGUUGCCAUCAAGA
12579
GAAcuGGuuGccAucAAGAdTsdT
sense


 


1763-1782
10580
UCUUGAUGGCAACCAGUUC
12580
UCUUGAUGGcAACcAGUUCdTsdT
antis


 


2185-2204
10581
GUACUACAGGGCACCAGAG
12581
GuAcuAcAGGGcAccAGAGdTsdT
sense


 


2185-2204
10582
CUCUGGUGCCCUGUAGUAC
12582
CUCUGGUGCCCUGuAGuACdTsdT
antis


 


2212-2231
10583
UGGAGCCACUGAUUACACG
12583
uGGAGccAcuGAuuAcAcGdTsdT
sense


 


2212-2231
10584
CGUGUAAUCAGUGGCUCCA
12584
CGUGuAAUcAGUGGCUCcAdTsdT
antis


 


2265-2284
10585
UGGCUGAAUUGUUGCUAGG
12585
uGGcuGAAuuGuuGcuAGGdTsdT
sense


 


2265-2284
10586
CCUAGCAACAAUUCAGCCA
12586
CCuAGcAAcAAUUcAGCcAdTsdT
antis


 


2326-2345
10587
GGAAAUAAUAAAGGUCCUA
12587
GGAAAuAAuAAAGGuccuAdTsdT
sense


 


2326-2345
10588
UAGGACCUUUAUUAUUUCC
12588
uAGGACCUUuAUuAUUUCCdTsdT
antis


 


2425-2444
10589
UUGGACAAAGGUCUUCCGG
12589
uuGGAcAAAGGucuuccGGdTsdT
sense


 


2425-2444
10590
CCGGAAGACCUUUGUCCAA
12590
CCGGAAGACCUUUGUCcAAdTsdT
antis


 


1962-1981
10591
AUAGUCGAGCCAAGCAGAC
12591
AuAGucGAGccAAGcAGAcdTsdT
sense


 


1962-1981
10592
GUCUGCUUGGCUCGACUAU
12592
GUCUGCUUGGCUCGACuAUdTsdT
antis


 


1803-1822
10593
UUAAGAACCGAGAGCUCCA
12593
uuAAGAAccGAGAGcuccAdTsdT
sense


 


1803-1822
10594
UGGAGCUCUCGGUUCUUAA
12594
UGGAGCUCUCGGUUCUuAAdTsdT
antis


 


1808-1827
10595
AACCGAGAGCUCCAGAUCA
12595
AAccGAGAGcuccAGAucAdTsdT
sense


 


1808-1827
10596
UGAUCUGGAGCUCUCGGUU
12596
UGAUCUGGAGCUCUCGGUUdTsdT
antis


 


1603-1622
10597
GAAAGUUAGCAGAGAUAAA
12597
GAAAGuuAGcAGAGAuAAAdTsdT
sense


 


1603-1622
10598
UUUAUCUCUGCUAACUUUC
12598
UUuAUCUCUGCuAACUUUCdTsdT
antis


 


1640-1659
10599
ACAGUAGUGGCAACUCCUG
12599
AcAGuAGuGGcAAcuccuGdTsdT
sense


 


1640-1659
10600
CAGGAGUUGCCACUACUGU
12600
cAGGAGUUGCcACuACUGUdTsdT
antis


 


1718-1737
10601
GGAUCAUUUGGUGUGGUAU
12601
GGAucAuuuGGuGuGGuAudTsdT
sense


 


1718-1737
10602
AUACCACACCAAAUGAUCC
12602
AuACcAcACcAAAUGAUCCdTsdT
antis


 


1807-1826
10603
GAACCGAGAGCUCCAGAUC
12603
GAAccGAGAGcuccAGAucdTsdT
sense


 


1807-1826
10604
GAUCUGGAGCUCUCGGUUC
12604
GAUCUGGAGCUCUCGGUUCdTsdT
antis


 


1904-1923
10605
UACCUUAACCUGGUGCUGG
12605
uAccuuAAccuGGuGcuGGdTsdT
sense


 


1904-1923
10606
CCAGCACCAGGUUAAGGUA
12606
CcAGcACcAGGUuAAGGuAdTsdT
antis


 


1905-1924
10607
ACCUUAACCUGGUGCUGGA
12607
AccuuAAccuGGuGcuGGAdTsdT
sense


 


1905-1924
10608
UCCAGCACCAGGUUAAGGU
12608
UCcAGcACcAGGUuAAGGUdTsdT
antis


 


1906-1925
10609
CCUUAACCUGGUGCUGGAC
12609
ccuuAAccuGGuGcuGGAcdTsdT
sense


 


1906-1925
10610
GUCCAGCACCAGGUUAAGG
12610
GUCcAGcACcAGGUuAAGGdTsdT
antis


 


2015-2034
10611
CAGCUGUUCAGAAGUCUAG
12611
cAGcuGuucAGAAGucuAGdTsdT
sense


 


2015-2034
10612
CUAGACUUCUGAACAGCUG
12612
CuAGACUUCUGAAcAGCUGdTsdT
antis


 


2057-2076
10613
UGCCAUCGAGACAUUAAAC
12613
uGccAucGAGAcAuuAAAcdTsdT
sense


 


2057-2076
10614
GUUUAAUGUCUCGAUGGCA
12614
GUUuAAUGUCUCGAUGGcAdTsdT
antis


 


2109-2128
10615
UAUUAAAACUCUGUGACUU
12615
uAuuAAAAcucuGuGAcuudTsdT
sense


 


2109-2128
10616
AAGUCACAGAGUUUUAAUA
12616
AAGUcAcAGAGUUUuAAuAdTsdT
antis


 


2126-2145
10617
UUUGGAAGUGCAAAGCAGC
12617
uuuGGAAGuGcAAAGcAGcdTsdT
sense


 


2126-2145
10618
GCUGCUUUGCACUUCCAAA
12618
GCUGCUUUGcACUUCcAAAdTsdT
antis


 


2129-2148
10619
GGAAGUGCAAAGCAGCUGG
12619
GGAAGuGcAAAGcAGcuGGdTsdT
sense


 


2129-2148
10620
CCAGCUGCUUUGCACUUCC
12620
CcAGCUGCUUUGcACUUCCdTsdT
antis


 


2312-2331
10621
GUGGAUCAGUUGGUGGAAA
12621
GuGGAucAGuuGGuGGAAAdTsdT
sense


 


2312-2331
10622
UUUCCACCAACUGAUCCAC
12622
UUUCcACcAACUGAUCcACdTsdT
antis


 


2313-2332
10623
UGGAUCAGUUGGUGGAAAU
12623
uGGAucAGuuGGuGGAAAudTsdT
sense


 


2313-2332
10624
AUUUCCACCAACUGAUCCA
12624
AUUUCcACcAACUGAUCcAdTsdT
antis


 


2347-2366
10625
AACACCAACAAGGGAGCAA
12625
AAcAccAAcAAGGGAGcAAdTsdT
sense


 


2347-2366
10626
UUGCUCCCUUGUUGGUGUU
12626
UUGCUCCCUUGUUGGUGUUdTsdT
antis


 


2373-2392
10627
AAAUGAACCCAAAUUAUAC
12627
AAAuGAAcccAAAuuAuAcdTsdT
sense


 


2373-2392
10628
GUAUAAUUUGGGUUCAUUU
12628
GuAuAAUUUGGGUUcAUUUdTsdT
antis


 


2431-2450
10629
AAAGGUCUUCCGGCCCCGA
12629
AAAGGucuuccGGccccGAdTsdT
sense


 


2431-2450
10630
UCGGGGCCGGAAGACCUUU
12630
UCGGGGCCGGAAGACCUUUdTsdT
antis


 


1632-1651
10631
AGGUAACCACAGUAGUGGC
12631
AGGuAAccAcAGuAGuGGcdTsdT
sense


 


1632-1651
10632
GCCACUACUGUGGUUACCU
12632
GCcACuACUGUGGUuACCUdTsdT
antis


 


2031-2050
10633
UAGCCUAUAUCCAUUCCUU
12633
uAGccuAuAuccAuuccuudTsdT
sense


 


2031-2050
10634
AAGGAAUGGAUAUAGGCUA
12634
AAGGAAUGGAuAuAGGCuAdTsdT
antis


 


1604-1623
10635
AAAGUUAGCAGAGAUAAAG
12635
AAAGuuAGcAGAGAuAAAGdTsdT
sense


 


1604-1623
10636
CUUUAUCUCUGCUAACUUU
12636
CUUuAUCUCUGCuAACUUUdTsdT
antis


 


1605-1624
10637
AAGUUAGCAGAGAUAAAGA
12637
AAGuuAGcAGAGAuAAAGAdTsdT
sense


 


1605-1624
10638
UCUUUAUCUCUGCUAACUU
12638
UCUUuAUCUCUGCuAACUUdTsdT
antis


 


1634-1653
10639
GUAACCACAGUAGUGGCAA
12639
GuAAccAcAGuAGuGGcAAdTsdT
sense


 


1634-1653
10640
UUGCCACUACUGUGGUUAC
12640
UUGCcACuACUGUGGUuACdTsdT
antis


 


1662-1681
10641
AGGGUCCUGACAGGCCACA
12641
AGGGuccuGAcAGGccAcAdTsdT
sense


 


1662-1681
10642
UGUGGCCUGUCAGGACCCU
12642
UGUGGCCUGUcAGGACCCUdTsdT
antis


 


1663-1682
10643
GGGUCCUGACAGGCCACAG
12643
GGGuccuGAcAGGccAcAGdTsdT
sense


 


1663-1682
10644
CUGUGGCCUGUCAGGACCC
12644
CUGUGGCCUGUcAGGACCCdTsdT
antis


 


1702-1721
10645
GAAAGUGAUUGGAAAUGGA
12645
GAAAGuGAuuGGAAAuGGAdTsdT
sense


 


1702-1721
10646
UCCAUUUCCAAUCACUUUC
12646
UCcAUUUCcAAUcACUUUCdTsdT
antis


 


1772-1791
10647
GCCAUCAAGAAAGUUCUAC
12647
GccAucAAGAAAGuucuAcdTsdT
sense


 


1772-1791
10648
GUAGAACUUUCUUGAUGGC
12648
GuAGAACUUUCUUGAUGGCdTsdT
antis


 


1776-1795
10649
UCAAGAAAGUUCUACAGGA
12649
ucAAGAAAGuucuAcAGGAdTsdT
sense


 


1776-1795
10650
UCCUGUAGAACUUUCUUGA
12650
UCCUGuAGAACUUUCUUGAdTsdT
antis


 


1792-1811
10651
GGACAAGCGAUUUAAGAAC
12651
GGAcAAGcGAuuuAAGAAcdTsdT
sense


 


1792-1811
10652
GUUCUUAAAUCGCUUGUCC
12652
GUUCUuAAAUCGCUUGUCCdTsdT
antis


 


1801-1820
10653
AUUUAAGAACCGAGAGCUC
12653
AuuuAAGAAccGAGAGcucdTsdT
sense


 


1801-1820
10654
GAGCUCUCGGUUCUUAAAU
12654
GAGCUCUCGGUUCUuAAAUdTsdT
antis


 


1813-1832
10655
AGAGCUCCAGAUCAUGAGA
12655
AGAGcuccAGAucAuGAGAdTsdT
sense


 


1813-1832
10656
UCUCAUGAUCUGGAGCUCU
12656
UCUcAUGAUCUGGAGCUCUdTsdT
antis


 


1859-1878
10657
CUGCGGUAUUUCUUCUACU
12657
cuGcGGuAuuucuucuAcudTsdT
sense


 


1859-1878
10658
AGUAGAAGAAAUACCGCAG
12658
AGuAGAAGAAAuACCGcAGdTsdT
antis


 


1860-1879
10659
UGCGGUAUUUCUUCUACUC
12659
uGcGGuAuuucuucuAcucdTsdT
sense


 


1860-1879
10660
GAGUAGAAGAAAUACCGCA
12660
GAGuAGAAGAAAuACCGcAdTsdT
antis


 


1900-1919
10661
GGUCUACCUUAACCUGGUG
12661
GGucuAccuuAAccuGGuGdTsdT
sense


 


1900-1919
10662
CACCAGGUUAAGGUAGACC
12662
cACcAGGUuAAGGuAGACCdTsdT
antis


 


1909-1928
10663
UAACCUGGUGCUGGACUAU
12663
uAAccuGGuGcuGGAcuAudTsdT
sense


 


1909-1928
10664
AUAGUCCAGCACCAGGUUA
12664
AuAGUCcAGcACcAGGUuAdTsdT
antis


 


1982-2001
10665
CUCCCUGUGAUCUAUGUCA
12665
cucccuGuGAucuAuGucAdTsdT
sense


 


1982-2001
10666
UGACAUAGAUCACAGGGAG
12666
UGAcAuAGAUcAcAGGGAGdTsdT
antis


 


2125-2144
10667
CUUUGGAAGUGCAAAGCAG
12667
cuuuGGAAGuGcAAAGcAGdTsdT
sense


 


2125-2144
10668
CUGCUUUGCACUUCCAAAG
12668
CUGCUUUGcACUUCcAAAGdTsdT
antis


 


2137-2156
10669
AAAGCAGCUGGUCCGAGGA
12669
AAAGcAGcuGGuccGAGGAdTsdT
sense


 


2137-2156
10670
UCCUCGGACCAGCUGCUUU
12670
UCCUCGGACcAGCUGCUUUdTsdT
antis


 


2156-2175
10671
GAGCCCAAUGUUUCAUAUA
12671
GAGcccAAuGuuucAuAuAdTsdT
sense


 


2156-2175
10672
UAUAUGAAACAUUGGGCUC
12672
uAuAUGAAAcAUUGGGCUCdTsdT
antis


 


2174-2193
10673
AUCUGUUCUCGGUACUACA
12673
AucuGuucucGGuAcuAcAdTsdT
sense


 


2174-2193
10674
UGUAGUACCGAGAACAGAU
12674
UGuAGuACCGAGAAcAGAUdTsdT
antis


 


2281-2300
10675
AGGACAACCAAUAUUUCCU
12675
AGGAcAAccAAuAuuuccudTsdT
sense


 


2281-2300
10676
AGGAAAUAUUGGUUGUCCU
12676
AGGAAAuAUUGGUUGUCCUdTsdT
antis


 


2282-2301
10677
GGACAACCAAUAUUUCCUG
12677
GGAcAAccAAuAuuuccuGdTsdT
sense


 


2282-2301
10678
CAGGAAAUAUUGGUUGUCC
12678
cAGGAAAuAUUGGUUGUCCdTsdT
antis


 


2317-2336
10679
UCAGUUGGUGGAAAUAAUA
12679
ucAGuuGGuGGAAAuAAuAdTsdT
sense


 


2317-2336
10680
UAUUAUUUCCACCAACUGA
12680
uAUuAUUUCcACcAACUGAdTsdT
antis


 


2346-2365
10681
GAACACCAACAAGGGAGCA
12681
GAAcAccAAcAAGGGAGcAdTsdT
sense


 


2346-2365
10682
UGCUCCCUUGUUGGUGUUC
12682
UGCUCCCUUGUUGGUGUUCdTsdT
antis


 


2401-2420
10683
AUUCCCUCAAAUCAAGGCA
12683
AuucccucAAAucAAGGcAdTsdT
sense


 


2401-2420
10684
UGCCUUGAUUUGAGGGAAU
12684
UGCCUUGAUUUGAGGGAAUdTsdT
antis


 


2402-2421
10685
UUCCCUCAAAUCAAGGCAC
12685
uucccucAAAucAAGGcAcdTsdT
sense


 


2402-2421
10686
GUGCCUUGAUUUGAGGGAA
12686
GUGCCUUGAUUUGAGGGAAdTsdT
antis


 


2463-2482
10687
CAAUUGCACUGUGCAGCCG
12687
cAAuuGcAcuGuGcAGccGdTsdT
sense


 


2463-2482
10688
CGGCUGCACAGUGCAAUUG
12688
CGGCUGcAcAGUGcAAUUGdTsdT
antis


 


1537-1556
10689
ACCGAGAACCACCUCCUUU
12689
AccGAGAAccAccuccuuudTsdT
sense


 


1537-1556
10690
AAAGGAGGUGGUUCUCGGU
12690
AAAGGAGGUGGUUCUCGGUdTsdT
antis


 


1554-1573
10691
UUGCGGAGAGCUGCAAGCC
12691
uuGcGGAGAGcuGcAAGccdTsdT
sense


 


1554-1573
10692
GGCUUGCAGCUCUCCGCAA
12692
GGCUUGcAGCUCUCCGcAAdTsdT
antis


 


1555-1574
10693
UGCGGAGAGCUGCAAGCCA
12693
uGcGGAGAGcuGcAAGccAdTsdT
sense


 


1555-1574
10694
UGGCUUGCAGCUCUCCGCA
12694
UGGCUUGcAGCUCUCCGcAdTsdT
antis


 


1562-1581
10695
AGCUGCAAGCCAGUGCAGC
12695
AGcuGcAAGccAGuGcAGcdTsdT
sense


 


1562-1581
10696
GCUGCACUGGCUUGCAGCU
12696
GCUGcACUGGCUUGcAGCUdTsdT
antis


 


1563-1582
10697
GCUGCAAGCCAGUGCAGCA
12697
GcuGcAAGccAGuGcAGcAdTsdT
sense


 


1563-1582
10698
UGCUGCACUGGCUUGCAGC
12698
UGCUGcACUGGCUUGcAGCdTsdT
antis


 


1570-1589
10699
GCCAGUGCAGCAGCCUUCA
12699
GccAGuGcAGcAGccuucAdTsdT
sense


 


1570-1589
10700
UGAAGGCUGCUGCACUGGC
12700
UGAAGGCUGCUGcACUGGCdTsdT
antis


 


1571-1590
10701
CCAGUGCAGCAGCCUUCAG
12701
ccAGuGcAGcAGccuucAGdTsdT
sense


 


1571-1590
10702
CUGAAGGCUGCUGCACUGG
12702
CUGAAGGCUGCUGcACUGGdTsdT
antis


 


1589-1608
10703
GCUUUUGGUAGCAUGAAAG
12703
GcuuuuGGuAGcAuGAAAGdTsdT
sense


 


1589-1608
10704
CUUUCAUGCUACCAAAAGC
12704
CUUUcAUGCuACcAAAAGCdTsdT
antis


 


1595-1614
10705
GGUAGCAUGAAAGUUAGCA
12705
GGuAGcAuGAAAGuuAGcAdTsdT
sense


 


1595-1614
10706
UGCUAACUUUCAUGCUACC
12706
UGCuAACUUUcAUGCuACCdTsdT
antis


 


1596-1615
10707
GUAGCAUGAAAGUUAGCAG
12707
GuAGcAuGAAAGuuAGcAGdTsdT
sense


 


1596-1615
10708
CUGCUAACUUUCAUGCUAC
12708
CUGCuAACUUUcAUGCuACdTsdT
antis


 


1597-1616
10709
UAGCAUGAAAGUUAGCAGA
12709
uAGcAuGAAAGuuAGcAGAdTsdT
sense


 


1597-1616
10710
UCUGCUAACUUUCAUGCUA
12710
UCUGCuAACUUUcAUGCuAdTsdT
antis


 


1606-1625
10711
AGUUAGCAGAGAUAAAGAU
12711
AGuuAGcAGAGAuAAAGAudTsdT
sense


 


1606-1625
10712
AUCUUUAUCUCUGCUAACU
12712
AUCUUuAUCUCUGCuAACUdTsdT
antis


 


1607-1626
10713
GUUAGCAGAGAUAAAGAUG
12713
GuuAGcAGAGAuAAAGAuGdTsdT
sense


 


1607-1626
10714
CAUCUUUAUCUCUGCUAAC
12714
cAUCUUuAUCUCUGCuAACdTsdT
antis


 


1608-1627
10715
UUAGCAGAGAUAAAGAUGG
12715
uuAGcAGAGAuAAAGAuGGdTsdT
sense


 


1608-1627
10716
CCAUCUUUAUCUCUGCUAA
12716
CcAUCUUuAUCUCUGCuAAdTsdT
antis


 


1616-1635
10717
GAUAAAGAUGGCAGCAAGG
12717
GAuAAAGAuGGcAGcAAGGdTsdT
sense


 


1616-1635
10718
CCUUGCUGCCAUCUUUAUC
12718
CCUUGCUGCcAUCUUuAUCdTsdT
antis


 


1617-1636
10719
AUAAAGAUGGCAGCAAGGU
12719
AuAAAGAuGGcAGcAAGGudTsdT
sense


 


1617-1636
10720
ACCUUGCUGCCAUCUUUAU
12720
ACCUUGCUGCcAUCUUuAUdTsdT
antis


 


1638-1657
10721
CCACAGUAGUGGCAACUCC
12721
ccAcAGuAGuGGcAAcuccdTsdT
sense


 


1638-1657
10722
GGAGUUGCCACUACUGUGG
12722
GGAGUUGCcACuACUGUGGdTsdT
antis


 


1647-1666
10723
UGGCAACUCCUGGCCAGGG
12723
uGGcAAcuccuGGccAGGGdTsdT
sense


 


1647-1666
10724
CCCUGGCCAGGAGUUGCCA
12724
CCCUGGCcAGGAGUUGCcAdTsdT
antis


 


1657-1676
10725
UGGCCAGGGUCCUGACAGG
12725
uGGccAGGGuccuGAcAGGdTsdT
sense


 


1657-1676
10726
CCUGUCAGGACCCUGGCCA
12726
CCUGUcAGGACCCUGGCcAdTsdT
antis


 


1660-1679
10727
CCAGGGUCCUGACAGGCCA
12727
ccAGGGuccuGAcAGGccAdTsdT
sense


 


1660-1679
10728
UGGCCUGUCAGGACCCUGG
12728
UGGCCUGUcAGGACCCUGGdTsdT
antis


 


1664-1683
10729
GGUCCUGACAGGCCACAGG
12729
GGuccuGAcAGGccAcAGGdTsdT
sense


 


1664-1683
10730
CCUGUGGCCUGUCAGGACC
12730
CCUGUGGCCUGUcAGGACCdTsdT
antis


 


1668-1687
10731
CUGACAGGCCACAGGAAGU
12731
cuGAcAGGccAcAGGAAGudTsdT
sense


 


1668-1687
10732
ACUUCCUGUGGCCUGUCAG
12732
ACUUCCUGUGGCCUGUcAGdTsdT
antis


 


1692-1711
10733
AUACAGACACGAAAGUGAU
12733
AuAcAGAcAcGAAAGuGAudTsdT
sense


 


1692-1711
10734
AUCACUUUCGUGUCUGUAU
12734
AUcACUUUCGUGUCUGuAUdTsdT
antis


 


1694-1713
10735
ACAGACACGAAAGUGAUUG
12735
AcAGAcAcGAAAGuGAuuGdTsdT
sense


 


1694-1713
10736
CAAUCACUUUCGUGUCUGU
12736
cAAUcACUUUCGUGUCUGUdTsdT
antis


 


1716-1735
10737
AUGGAUCAUUUGGUGUGGU
12737
AuGGAucAuuuGGuGuGGudTsdT
sense


 


1716-1735
10738
ACCACACCAAAUGAUCCAU
12738
ACcAcACcAAAUGAUCcAUdTsdT
antis


 


1730-1749
10739
GUGGUAUAUCAAGCCAAAC
12739
GuGGuAuAucAAGccAAAcdTsdT
sense


 


1730-1749
10740
GUUUGGCUUGAUAUACCAC
12740
GUUUGGCUUGAuAuACcACdTsdT
antis


 


1764-1783
10741
AACUGGUUGCCAUCAAGAA
12741
AAcuGGuuGccAucAAGAAdTsdT
sense


 


1764-1783
10742
UUCUUGAUGGCAACCAGUU
12742
UUCUUGAUGGcAACcAGUUdTsdT
antis


 


1765-1784
10743
ACUGGUUGCCAUCAAGAAA
12743
AcuGGuuGccAucAAGAAAdTsdT
sense


 


1765-1784
10744
UUUCUUGAUGGCAACCAGU
12744
UUUCUUGAUGGcAACcAGUdTsdT
antis


 


1766-1785
10745
CUGGUUGCCAUCAAGAAAG
12745
cuGGuuGccAucAAGAAAGdTsdT
sense


 


1766-1785
10746
CUUUCUUGAUGGCAACCAG
12746
CUUUCUUGAUGGcAACcAGdTsdT
antis


 


1771-1790
10747
UGCCAUCAAGAAAGUUCUA
12747
uGccAucAAGAAAGuucuAdTsdT
sense


 


1771-1790
10748
UAGAACUUUCUUGAUGGCA
12748
uAGAACUUUCUUGAUGGcAdTsdT
antis


 


1777-1796
10749
CAAGAAAGUUCUACAGGAC
12749
cAAGAAAGuucuAcAGGAcdTsdT
sense


 


1777-1796
10750
GUCCUGUAGAACUUUCUUG
12750
GUCCUGuAGAACUUUCUUGdTsdT
antis


 


1811-1830
10751
CGAGAGCUCCAGAUCAUGA
12751
cGAGAGcuccAGAucAuGAdTsdT
sense


 


1811-1830
10752
UCAUGAUCUGGAGCUCUCG
12752
UcAUGAUCUGGAGCUCUCGdTsdT
antis


 


1814-1833
10753
GAGCUCCAGAUCAUGAGAA
12753
GAGcuccAGAucAuGAGAAdTsdT
sense


 


1814-1833
10754
UUCUCAUGAUCUGGAGCUC
12754
UUCUcAUGAUCUGGAGCUCdTsdT
antis


 


1835-1854
10755
CUAGACCACUGUAACAUAG
12755
cuAGAccAcuGuAAcAuAGdTsdT
sense


 


1835-1854
10756
CUAUGUUACAGUGGUCUAG
12756
CuAUGUuAcAGUGGUCuAGdTsdT
antis


 


1881-1900
10757
GUGGUGAGAAGAAAGAUGA
12757
GuGGuGAGAAGAAAGAuGAdTsdT
sense


 


1881-1900
10758
UCAUCUUUCUUCUCACCAC
12758
UcAUCUUUCUUCUcACcACdTsdT
antis


 


1882-1901
10759
UGGUGAGAAGAAAGAUGAG
12759
uGGuGAGAAGAAAGAuGAGdTsdT
sense


 


1882-1901
10760
CUCAUCUUUCUUCUCACCA
12760
CUcAUCUUUCUUCUcACcAdTsdT
antis


 


1902-1921
10761
UCUACCUUAACCUGGUGCU
12761
ucuAccuuAAccuGGuGcudTsdT
sense


 


1902-1921
10762
AGCACCAGGUUAAGGUAGA
12762
AGcACcAGGUuAAGGuAGAdTsdT
antis


 


1914-1933
10763
UGGUGCUGGACUAUGUUCC
12763
uGGuGcuGGAcuAuGuuccdTsdT
sense


 


1914-1933
10764
GGAACAUAGUCCAGCACCA
12764
GGAAcAuAGUCcAGcACcAdTsdT
antis


 


1932-1951
10765
CGGAGACAGUGUACAGAGU
12765
cGGAGAcAGuGuAcAGAGudTsdT
sense


 


1932-1951
10766
ACUCUGUACACUGUCUCCG
12766
ACUCUGuAcACUGUCUCCGdTsdT
antis


 


1968-1987
10767
GAGCCAAGCAGACACUCCC
12767
GAGccAAGcAGAcAcucccdTsdT
sense


 


1968-1987
10768
GGGAGUGUCUGCUUGGCUC
12768
GGGAGUGUCUGCUUGGCUCdTsdT
antis


 


1969-1988
10769
AGCCAAGCAGACACUCCCU
12769
AGccAAGcAGAcAcucccudTsdT
sense


 


1969-1988
10770
AGGGAGUGUCUGCUUGGCU
12770
AGGGAGUGUCUGCUUGGCUdTsdT
antis


 


1976-1995
10771
CAGACACUCCCUGUGAUCU
12771
cAGAcAcucccuGuGAucudTsdT
sense


 


1976-1995
10772
AGAUCACAGGGAGUGUCUG
12772
AGAUcAcAGGGAGUGUCUGdTsdT
antis


 


2002-2021
10773
GUUGUAUAUGUAUCAGCUG
12773
GuuGuAuAuGuAucAGcuGdTsdT
sense


 


2002-2021
10774
CAGCUGAUACAUAUACAAC
12774
cAGCUGAuAcAuAuAcAACdTsdT
antis


 


2013-2032
10775
AUCAGCUGUUCAGAAGUCU
12775
AucAGcuGuucAGAAGucudTsdT
sense


 


2013-2032
10776
AGACUUCUGAACAGCUGAU
12776
AGACUUCUGAAcAGCUGAUdTsdT
antis


 


2014-2033
10777
UCAGCUGUUCAGAAGUCUA
12777
ucAGcuGuucAGAAGucuAdTsdT
sense


 


2014-2033
10778
UAGACUUCUGAACAGCUGA
12778
uAGACUUCUGAAcAGCUGAdTsdT
antis


 


2032-2051
10779
AGCCUAUAUCCAUUCCUUU
12779
AGccuAuAuccAuuccuuudTsdT
sense


 


2032-2051
10780
AAAGGAAUGGAUAUAGGCU
12780
AAAGGAAUGGAuAuAGGCUdTsdT
antis


 


2033-2052
10781
GCCUAUAUCCAUUCCUUUG
12781
GccuAuAuccAuuccuuuGdTsdT
sense


 


2033-2052
10782
CAAAGGAAUGGAUAUAGGC
12782
cAAAGGAAUGGAuAuAGGCdTsdT
antis


 


2034-2053
10783
CCUAUAUCCAUUCCUUUGG
12783
ccuAuAuccAuuccuuuGGdTsdT
sense


 


2034-2053
10784
CCAAAGGAAUGGAUAUAGG
12784
CcAAAGGAAUGGAuAuAGGdTsdT
antis


 


2037-2056
10785
AUAUCCAUUCCUUUGGAAU
12785
AuAuccAuuccuuuGGAAudTsdT
sense


 


2037-2056
10786
AUUCCAAAGGAAUGGAUAU
12786
AUUCcAAAGGAAUGGAuAUdTsdT
antis


 


2038-2057
10787
UAUCCAUUCCUUUGGAAUC
12787
uAuccAuuccuuuGGAAucdTsdT
sense


 


2038-2057
10788
GAUUCCAAAGGAAUGGAUA
12788
GAUUCcAAAGGAAUGGAuAdTsdT
antis


 


2041-2060
10789
CCAUUCCUUUGGAAUCUGC
12789
ccAuuccuuuGGAAucuGcdTsdT
sense


 


2041-2060
10790
GCAGAUUCCAAAGGAAUGG
12790
GcAGAUUCcAAAGGAAUGGdTsdT
antis


 


2045-2064
10791
UCCUUUGGAAUCUGCCAUC
12791
uccuuuGGAAucuGccAucdTsdT
sense


 


2045-2064
10792
GAUGGCAGAUUCCAAAGGA
12792
GAUGGcAGAUUCcAAAGGAdTsdT
antis


 


2069-2088
10793
AUUAAACCACAGAACCUCU
12793
AuuAAAccAcAGAAccucudTsdT
sense


 


2069-2088
10794
AGAGGUUCUGUGGUUUAAU
12794
AGAGGUUCUGUGGUUuAAUdTsdT
antis


 


2110-2129
10795
AUUAAAACUCUGUGACUUU
12795
AuuAAAAcucuGuGAcuuudTsdT
sense


 


2110-2129
10796
AAAGUCACAGAGUUUUAAU
12796
AAAGUcAcAGAGUUUuAAUdTsdT
antis


 


2111-2130
10797
UUAAAACUCUGUGACUUUG
12797
uuAAAAcucuGuGAcuuuGdTsdT
sense


 


2111-2130
10798
CAAAGUCACAGAGUUUUAA
12798
cAAAGUcAcAGAGUUUuAAdTsdT
antis


 


2114-2133
10799
AAACUCUGUGACUUUGGAA
12799
AAAcucuGuGAcuuuGGAAdTsdT
sense


 


2114-2133
10800
UUCCAAAGUCACAGAGUUU
12800
UUCcAAAGUcAcAGAGUUUdTsdT
antis


 


2121-2140
10801
GUGACUUUGGAAGUGCAAA
12801
GuGAcuuuGGAAGuGcAAAdTsdT
sense


 


2121-2140
10802
UUUGCACUUCCAAAGUCAC
12802
UUUGcACUUCcAAAGUcACdTsdT
antis


 


2122-2141
10803
UGACUUUGGAAGUGCAAAG
12803
uGAcuuuGGAAGuGcAAAGdTsdT
sense


 


2122-2141
10804
CUUUGCACUUCCAAAGUCA
12804
CUUUGcACUUCcAAAGUcAdTsdT
antis


 


2127-2146
10805
UUGGAAGUGCAAAGCAGCU
12805
uuGGAAGuGcAAAGcAGcudTsdT
sense


 


2127-2146
10806
AGCUGCUUUGCACUUCCAA
12806
AGCUGCUUUGcACUUCcAAdTsdT
antis


 


2128-2147
10807
UGGAAGUGCAAAGCAGCUG
12807
uGGAAGuGcAAAGcAGcuGdTsdT
sense


 


2128-2147
10808
CAGCUGCUUUGCACUUCCA
12808
cAGCUGCUUUGcACUUCcAdTsdT
antis


 


2130-2149
10809
GAAGUGCAAAGCAGCUGGU
12809
GAAGuGcAAAGcAGcuGGudTsdT
sense


 


2130-2149
10810
ACCAGCUGCUUUGCACUUC
12810
ACcAGCUGCUUUGcACUUCdTsdT
antis


 


2144-2163
10811
CUGGUCCGAGGAGAGCCCA
12811
cuGGuccGAGGAGAGcccAdTsdT
sense


 


2144-2163
10812
UGGGCUCUCCUCGGACCAG
12812
UGGGCUCUCCUCGGACcAGdTsdT
antis


 


2145-2164
10813
UGGUCCGAGGAGAGCCCAA
12813
uGGuccGAGGAGAGcccAAdTsdT
sense


 


2145-2164
10814
UUGGGCUCUCCUCGGACCA
12814
UUGGGCUCUCCUCGGACcAdTsdT
antis


 


2152-2171
10815
AGGAGAGCCCAAUGUUUCA
12815
AGGAGAGcccAAuGuuucAdTsdT
sense


 


2152-2171
10816
UGAAACAUUGGGCUCUCCU
12816
UGAAAcAUUGGGCUCUCCUdTsdT
antis


 


2173-2192
10817
UAUCUGUUCUCGGUACUAC
12817
uAucuGuucucGGuAcuAcdTsdT
sense


 


2173-2192
10818
GUAGUACCGAGAACAGAUA
12818
GuAGuACCGAGAAcAGAuAdTsdT
antis


 


2244-2263
10819
UAUGGUCUGCAGGCUGUGU
12819
uAuGGucuGcAGGcuGuGudTsdT
sense


 


2244-2263
10820
ACACAGCCUGCAGACCAUA
12820
AcAcAGCCUGcAGACcAuAdTsdT
antis


 


2293-2312
10821
AUUUCCUGGGGACAGUGGU
12821
AuuuccuGGGGAcAGuGGudTsdT
sense


 


2293-2312
10822
ACCACUGUCCCCAGGAAAU
12822
ACcACUGUCCCcAGGAAAUdTsdT
antis


 


2296-2315
10823
UCCUGGGGACAGUGGUGUG
12823
uccuGGGGAcAGuGGuGuGdTsdT
sense


 


2296-2315
10824
CACACCACUGUCCCCAGGA
12824
cAcACcACUGUCCCcAGGAdTsdT
antis


 


2297-2316
10825
CCUGGGGACAGUGGUGUGG
12825
ccuGGGGAcAGuGGuGuGGdTsdT
sense


 


2297-2316
10826
CCACACCACUGUCCCCAGG
12826
CcAcACcACUGUCCCcAGGdTsdT
antis


 


2320-2339
10827
GUUGGUGGAAAUAAUAAAG
12827
GuuGGuGGAAAuAAuAAAGdTsdT
sense


 


2320-2339
10828
CUUUAUUAUUUCCACCAAC
12828
CUUuAUuAUUUCcACcAACdTsdT
antis


 


2321-2340
10829
UUGGUGGAAAUAAUAAAGG
12829
uuGGuGGAAAuAAuAAAGGdTsdT
sense


 


2321-2340
10830
CCUUUAUUAUUUCCACCAA
12830
CCUUuAUuAUUUCcACcAAdTsdT
antis


 


2322-2341
10831
UGGUGGAAAUAAUAAAGGU
12831
uGGuGGAAAuAAuAAAGGudTsdT
sense


 


2322-2341
10832
ACCUUUAUUAUUUCCACCA
12832
ACCUUuAUuAUUUCcACcAdTsdT
antis


 


2348-2367
10833
ACACCAACAAGGGAGCAAA
12833
AcAccAAcAAGGGAGcAAAdTsdT
sense


 


2348-2367
10834
UUUGCUCCCUUGUUGGUGU
12834
UUUGCUCCCUUGUUGGUGUdTsdT
antis


 


2349-2368
10835
CACCAACAAGGGAGCAAAU
12835
cAccAAcAAGGGAGcAAAudTsdT
sense


 


2349-2368
10836
AUUUGCUCCCUUGUUGGUG
12836
AUUUGCUCCCUUGUUGGUGdTsdT
antis


 


2389-2408
10837
UACAGAAUUCAAAUUCCCU
12837
uAcAGAAuucAAAuucccudTsdT
sense


 


2389-2408
10838
AGGGAAUUUGAAUUCUGUA
12838
AGGGAAUUUGAAUUCUGuAdTsdT
antis


 


2414-2433
10839
AAGGCACAUCCUUGGACAA
12839
AAGGcAcAuccuuGGAcAAdTsdT
sense


 


2414-2433
10840
UUGUCCAAGGAUGUGCCUU
12840
UUGUCcAAGGAUGUGCCUUdTsdT
antis


 


2419-2438
10841
ACAUCCUUGGACAAAGGUC
12841
AcAuccuuGGAcAAAGGucdTsdT
sense


 


2419-2438
10842
GACCUUUGUCCAAGGAUGU
12842
GACCUUUGUCcAAGGAUGUdTsdT
antis


 


2429-2448
10843
ACAAAGGUCUUCCGGCCCC
12843
AcAAAGGucuuccGGccccdTsdT
sense


 


2429-2448
10844
GGGGCCGGAAGACCUUUGU
12844
GGGGCCGGAAGACCUUUGUdTsdT
antis


 


2460-2479
10845
AGGCAAUUGCACUGUGCAG
12845
AGGcAAuuGcAcuGuGcAGdTsdT
sense


 


2460-2479
10846
CUGCACAGUGCAAUUGCCU
12846
CUGcAcAGUGcAAUUGCCUdTsdT
antis


 


2474-2493
10847
UGCAGCCGUCUGCUGGAGU
12847
uGcAGccGucuGcuGGAGudTsdT
sense


 


2474-2493
10848
ACUCCAGCAGACGGCUGCA
12848
ACUCcAGcAGACGGCUGcAdTsdT
antis


 


2480-2499
10849
CGUCUGCUGGAGUACACAC
12849
cGucuGcuGGAGuAcAcAcdTsdT
sense


 


2480-2499
10850
GUGUGUACUCCAGCAGACG
12850
GUGUGuACUCcAGcAGACGdTsdT
antis


 


2481-2500
10851
GUCUGCUGGAGUACACACC
12851
GucuGcuGGAGuAcAcAccdTsdT
sense


 


2481-2500
10852
GGUGUGUACUCCAGCAGAC
12852
GGUGUGuACUCcAGcAGACdTsdT
antis


 


2511-2530
10853
UAACACCACUGGAAGCUUG
12853
uAAcAccAcuGGAAGcuuGdTsdT
sense


 


2511-2530
10854
CAAGCUUCCAGUGGUGUUA
12854
cAAGCUUCcAGUGGUGUuAdTsdT
antis


 


1540-1559
10855
GAGAACCACCUCCUUUGCG
12855
GAGAAccAccuccuuuGcGdTsdT
sense


 


1540-1559
10856
CGCAAAGGAGGUGGUUCUC
12856
CGcAAAGGAGGUGGUUCUCdTsdT
antis


 


1883-1902
10857
GGUGAGAAGAAAGAUGAGG
12857
GGuGAGAAGAAAGAuGAGGdTsdT
sense


 


1883-1902
10858
CCUCAUCUUUCUUCUCACC
12858
CCUcAUCUUUCUUCUcACCdTsdT
antis


 


2044-2063
10859
UUCCUUUGGAAUCUGCCAU
12859
uuccuuuGGAAucuGccAudTsdT
sense


 


2044-2063
10860
AUGGCAGAUUCCAAAGGAA
12860
AUGGcAGAUUCcAAAGGAAdTsdT
antis


 


2205-2224
10861
UGAUCUUUGGAGCCACUGA
12861
uGAucuuuGGAGccAcuGAdTsdT
sense


 


2205-2224
10862
UCAGUGGCUCCAAAGAUCA
12862
UcAGUGGCUCcAAAGAUcAdTsdT
antis


 


2331-2350
10863
UAAUAAAGGUCCUAGGAAC
12863
uAAuAAAGGuccuAGGAAcdTsdT
sense


 


2331-2350
10864
GUUCCUAGGACCUUUAUUA
12864
GUUCCuAGGACCUUuAUuAdTsdT
antis


 


2384-2403
10865
AAUUAUACAGAAUUCAAAU
12865
AAuuAuAcAGAAuucAAAudTsdT
sense


 


2384-2403
10866
AUUUGAAUUCUGUAUAAUU
12866
AUUUGAAUUCUGuAuAAUUdTsdT
antis


 


1557-1576
10867
CGGAGAGCUGCAAGCCAGU
12867
cGGAGAGcuGcAAGccAGudTsdT
sense


 


1557-1576
10868
ACUGGCUUGCAGCUCUCCG
12868
ACUGGCUUGcAGCUCUCCGdTsdT
antis


 


1567-1586
10869
CAAGCCAGUGCAGCAGCCU
12869
cAAGccAGuGcAGcAGccudTsdT
sense


 


1567-1586
10870
AGGCUGCUGCACUGGCUUG
12870
AGGCUGCUGcACUGGCUUGdTsdT
antis


 


1568-1587
10871
AAGCCAGUGCAGCAGCCUU
12871
AAGccAGuGcAGcAGccuudTsdT
sense


 


1568-1587
10872
AAGGCUGCUGCACUGGCUU
12872
AAGGCUGCUGcACUGGCUUdTsdT
antis


 


1580-1599
10873
CAGCCUUCAGCUUUUGGUA
12873
cAGccuucAGcuuuuGGuAdTsdT
sense


 


1580-1599
10874
UACCAAAAGCUGAAGGCUG
12874
uACcAAAAGCUGAAGGCUGdTsdT
antis


 


1583-1602
10875
CCUUCAGCUUUUGGUAGCA
12875
ccuucAGcuuuuGGuAGcAdTsdT
sense


 


1583-1602
10876
UGCUACCAAAAGCUGAAGG
12876
UGCuACcAAAAGCUGAAGGdTsdT
antis


 


1590-1609
10877
CUUUUGGUAGCAUGAAAGU
12877
cuuuuGGuAGcAuGAAAGudTsdT
sense


 


1590-1609
10878
ACUUUCAUGCUACCAAAAG
12878
ACUUUcAUGCuACcAAAAGdTsdT
antis


 


1609-1628
10879
UAGCAGAGAUAAAGAUGGC
12879
uAGcAGAGAuAAAGAuGGcdTsdT
sense


 


1609-1628
10880
GCCAUCUUUAUCUCUGCUA
12880
GCcAUCUUuAUCUCUGCuAdTsdT
antis


 


1615-1634
10881
AGAUAAAGAUGGCAGCAAG
12881
AGAuAAAGAuGGcAGcAAGdTsdT
sense


 


1615-1634
10882
CUUGCUGCCAUCUUUAUCU
12882
CUUGCUGCcAUCUUuAUCUdTsdT
antis


 


1655-1674
10883
CCUGGCCAGGGUCCUGACA
12883
ccuGGccAGGGuccuGAcAdTsdT
sense


 


1655-1674
10884
UGUCAGGACCCUGGCCAGG
12884
UGUcAGGACCCUGGCcAGGdTsdT
antis


 


1671-1690
10885
ACAGGCCACAGGAAGUCAG
12885
AcAGGccAcAGGAAGucAGdTsdT
sense


 


1671-1690
10886
CUGACUUCCUGUGGCCUGU
12886
CUGACUUCCUGUGGCCUGUdTsdT
antis


 


1672-1691
10887
CAGGCCACAGGAAGUCAGU
12887
cAGGccAcAGGAAGucAGudTsdT
sense


 


1672-1691
10888
ACUGACUUCCUGUGGCCUG
12888
ACUGACUUCCUGUGGCCUGdTsdT
antis


 


1747-1766
10889
ACUUUGUGAUUCUGGAGAA
12889
AcuuuGuGAuucuGGAGAAdTsdT
sense


 


1747-1766
10890
UUCUCCAGAAUCACAAAGU
12890
UUCUCcAGAAUcAcAAAGUdTsdT
antis


 


1748-1767
10891
CUUUGUGAUUCUGGAGAAC
12891
cuuuGuGAuucuGGAGAAcdTsdT
sense


 


1748-1767
10892
GUUCUCCAGAAUCACAAAG
12892
GUUCUCcAGAAUcAcAAAGdTsdT
antis


 


1750-1769
10893
UUGUGAUUCUGGAGAACUG
12893
uuGuGAuucuGGAGAAcuGdTsdT
sense


 


1750-1769
10894
CAGUUCUCCAGAAUCACAA
12894
cAGUUCUCcAGAAUcAcAAdTsdT
antis


 


1751-1770
10895
UGUGAUUCUGGAGAACUGG
12895
uGuGAuucuGGAGAAcuGGdTsdT
sense


 


1751-1770
10896
CCAGUUCUCCAGAAUCACA
12896
CcAGUUCUCcAGAAUcAcAdTsdT
antis


 


1752-1771
10897
GUGAUUCUGGAGAACUGGU
12897
GuGAuucuGGAGAAcuGGudTsdT
sense


 


1752-1771
10898
ACCAGUUCUCCAGAAUCAC
12898
ACcAGUUCUCcAGAAUcACdTsdT
antis


 


1753-1772
10899
UGAUUCUGGAGAACUGGUU
12899
uGAuucuGGAGAAcuGGuudTsdT
sense


 


1753-1772
10900
AACCAGUUCUCCAGAAUCA
12900
AACcAGUUCUCcAGAAUcAdTsdT
antis


 


2117-2136
10901
CUCUGUGACUUUGGAAGUG
12901
cucuGuGAcuuuGGAAGuGdTsdT
sense


 


2117-2136
10902
CACUUCCAAAGUCACAGAG
12902
cACUUCcAAAGUcAcAGAGdTsdT
antis


 


2118-2137
10903
UCUGUGACUUUGGAAGUGC
12903
ucuGuGAcuuuGGAAGuGcdTsdT
sense


 


2118-2137
10904
GCACUUCCAAAGUCACAGA
12904
GcACUUCcAAAGUcAcAGAdTsdT
antis


 


2148-2167
10905
UCCGAGGAGAGCCCAAUGU
12905
uccGAGGAGAGcccAAuGudTsdT
sense


 


2148-2167
10906
ACAUUGGGCUCUCCUCGGA
12906
AcAUUGGGCUCUCCUCGGAdTsdT
antis


 


2202-2221
10907
AGUUGAUCUUUGGAGCCAC
12907
AGuuGAucuuuGGAGccAcdTsdT
sense


 


2202-2221
10908
GUGGCUCCAAAGAUCAACU
12908
GUGGCUCcAAAGAUcAACUdTsdT
antis


 


2203-2222
10909
GUUGAUCUUUGGAGCCACU
12909
GuuGAucuuuGGAGccAcudTsdT
sense


 


2203-2222
10910
AGUGGCUCCAAAGAUCAAC
12910
AGUGGCUCcAAAGAUcAACdTsdT
antis


 


2204-2223
10911
UUGAUCUUUGGAGCCACUG
12911
uuGAucuuuGGAGccAcuGdTsdT
sense


 


2204-2223
10912
CAGUGGCUCCAAAGAUCAA
12912
cAGUGGCUCcAAAGAUcAAdTsdT
antis


 


2206-2225
10913
GAUCUUUGGAGCCACUGAU
12913
GAucuuuGGAGccAcuGAudTsdT
sense


 


2206-2225
10914
AUCAGUGGCUCCAAAGAUC
12914
AUcAGUGGCUCcAAAGAUCdTsdT
antis


 


2245-2264
10915
AUGGUCUGCAGGCUGUGUG
12915
AuGGucuGcAGGcuGuGuGdTsdT
sense


 


2245-2264
10916
CACACAGCCUGCAGACCAU
12916
cAcAcAGCCUGcAGACcAUdTsdT
antis


 


2252-2271
10917
GCAGGCUGUGUGUUGGCUG
12917
GcAGGcuGuGuGuuGGcuGdTsdT
sense


 


2252-2271
10918
CAGCCAACACACAGCCUGC
12918
cAGCcAAcAcAcAGCCUGCdTsdT
antis


 


2266-2285
10919
GGCUGAAUUGUUGCUAGGA
12919
GGcuGAAuuGuuGcuAGGAdTsdT
sense


 


2266-2285
10920
UCCUAGCAACAAUUCAGCC
12920
UCCuAGcAAcAAUUcAGCCdTsdT
antis


 


2294-2313
10921
UUUCCUGGGGACAGUGGUG
12921
uuuccuGGGGAcAGuGGuGdTsdT
sense


 


2294-2313
10922
CACCACUGUCCCCAGGAAA
12922
cACcACUGUCCCcAGGAAAdTsdT
antis


 


2295-2314
10923
UUCCUGGGGACAGUGGUGU
12923
uuccuGGGGAcAGuGGuGudTsdT
sense


 


2295-2314
10924
ACACCACUGUCCCCAGGAA
12924
AcACcACUGUCCCcAGGAAdTsdT
antis


 


2350-2369
10925
ACCAACAAGGGAGCAAAUU
12925
AccAAcAAGGGAGcAAAuudTsdT
sense


 


2350-2369
10926
AAUUUGCUCCCUUGUUGGU
12926
AAUUUGCUCCCUUGUUGGUdTsdT
antis


 


2382-2401
10927
CAAAUUAUACAGAAUUCAA
12927
cAAAuuAuAcAGAAuucAAdTsdT
sense


 


2382-2401
10928
UUGAAUUCUGUAUAAUUUG
12928
UUGAAUUCUGuAuAAUUUGdTsdT
antis


 


1543-1562
10929
AACCACCUCCUUUGCGGAG
12929
AAccAccuccuuuGcGGAGdTsdT
sense


 


1543-1562
10930
CUCCGCAAAGGAGGUGGUU
12930
CUCCGcAAAGGAGGUGGUUdTsdT
antis


 


1544-1563
10931
ACCACCUCCUUUGCGGAGA
12931
AccAccuccuuuGcGGAGAdTsdT
sense


 


1544-1563
10932
UCUCCGCAAAGGAGGUGGU
12932
UCUCCGcAAAGGAGGUGGUdTsdT
antis


 


1545-1564
10933
CCACCUCCUUUGCGGAGAG
12933
ccAccuccuuuGcGGAGAGdTsdT
sense


 


1545-1564
10934
CUCUCCGCAAAGGAGGUGG
12934
CUCUCCGcAAAGGAGGUGGdTsdT
antis


 


1712-1731
10935
GGAAAUGGAUCAUUUGGUG
12935
GGAAAuGGAucAuuuGGuGdTsdT
sense


 


1712-1731
10936
CACCAAAUGAUCCAUUUCC
12936
cACcAAAUGAUCcAUUUCCdTsdT
antis


 


1879-1898
10937
GAGUGGUGAGAAGAAAGAU
12937
GAGuGGuGAGAAGAAAGAudTsdT
sense


 


1879-1898
10938
AUCUUUCUUCUCACCACUC
12938
AUCUUUCUUCUcACcACUCdTsdT
antis


 


2060-2079
10939
CAUCGAGACAUUAAACCAC
12939
cAucGAGAcAuuAAAccAcdTsdT
sense


 


2060-2079
10940
GUGGUUUAAUGUCUCGAUG
12940
GUGGUUuAAUGUCUCGAUGdTsdT
antis


 


2062-2081
10941
UCGAGACAUUAAACCACAG
12941
ucGAGAcAuuAAAccAcAGdTsdT
sense


 


2062-2081
10942
CUGUGGUUUAAUGUCUCGA
12942
CUGUGGUUuAAUGUCUCGAdTsdT
antis


 


2061-2080
10943
AUCGAGACAUUAAACCACA
12943
AucGAGAcAuuAAAccAcAdTsdT
sense


 


2061-2080
10944
UGUGGUUUAAUGUCUCGAU
12944
UGUGGUUuAAUGUCUCGAUdTsdT
antis


 


2058-2077
10945
GCCAUCGAGACAUUAAACC
12945
GccAucGAGAcAuuAAAccdTsdT
sense


 


2058-2077
10946
GGUUUAAUGUCUCGAUGGC
12946
GGUUuAAUGUCUCGAUGGCdTsdT
antis


 


2059-2078
10947
CCAUCGAGACAUUAAACCA
12947
ccAucGAGAcAuuAAAccAdTsdT
sense


 


2059-2078
10948
UGGUUUAAUGUCUCGAUGG
12948
UGGUUuAAUGUCUCGAUGGdTsdT
antis


 


1639-1658
10949
CACAGUAGUGGCAACUCCU
12949
cAcAGuAGuGGcAAcuccudTsdT
sense


 


1639-1658
10950
AGGAGUUGCCACUACUGUG
12950
AGGAGUUGCcACuACUGUGdTsdT
antis


 


2064-2083
10951
GAGACAUUAAACCACAGAA
12951
GAGAcAuuAAAccAcAGAAdTsdT
sense


 


2064-2083
10952
UUCUGUGGUUUAAUGUCUC
12952
UUCUGUGGUUuAAUGUCUCdTsdT
antis


 


1641-1660
10953
CAGUAGUGGCAACUCCUGG
12953
cAGuAGuGGcAAcuccuGGdTsdT
sense


 


1641-1660
10954
CCAGGAGUUGCCACUACUG
12954
CcAGGAGUUGCcACuACUGdTsdT
antis


 


1812-1831
10955
GAGAGCUCCAGAUCAUGAG
12955
GAGAGcuccAGAucAuGAGdTsdT
sense


 


1812-1831
10956
CUCAUGAUCUGGAGCUCUC
12956
CUcAUGAUCUGGAGCUCUCdTsdT
antis


 


2063-2082
10957
CGAGACAUUAAACCACAGA
12957
cGAGAcAuuAAAccAcAGAdTsdT
sense


 


2063-2082
10958
UCUGUGGUUUAAUGUCUCG
12958
UCUGUGGUUuAAUGUCUCGdTsdT
antis


 


2065-2084
10959
AGACAUUAAACCACAGAAC
12959
AGAcAuuAAAccAcAGAAcdTsdT
sense


 


2065-2084
10960
GUUCUGUGGUUUAAUGUCU
12960
GUUCUGUGGUUuAAUGUCUdTsdT
antis


 


2112-2131
10961
UAAAACUCUGUGACUUUGG
12961
uAAAAcucuGuGAcuuuGGdTsdT
sense


 


2112-2131
10962
CCAAAGUCACAGAGUUUUA
12962
CcAAAGUcAcAGAGUUUuAdTsdT
antis


 


2119-2138
10963
CUGUGACUUUGGAAGUGCA
12963
cuGuGAcuuuGGAAGuGcAdTsdT
sense


 


2119-2138
10964
UGCACUUCCAAAGUCACAG
12964
UGcACUUCcAAAGUcAcAGdTsdT
antis


 


2123-2142
10965
GACUUUGGAAGUGCAAAGC
12965
GAcuuuGGAAGuGcAAAGcdTsdT
sense


 


2123-2142
10966
GCUUUGCACUUCCAAAGUC
12966
GCUUUGcACUUCcAAAGUCdTsdT
antis


 


2131-2150
10967
AAGUGCAAAGCAGCUGGUC
12967
AAGuGcAAAGcAGcuGGucdTsdT
sense


 


2131-2150
10968
GACCAGCUGCUUUGCACUU
12968
GACcAGCUGCUUUGcACUUdTsdT
antis


 


1715-1734
10969
AAUGGAUCAUUUGGUGUGG
12969
AAuGGAucAuuuGGuGuGGdTsdT
sense


 


1715-1734
10970
CCACACCAAAUGAUCCAUU
12970
CcAcACcAAAUGAUCcAUUdTsdT
antis


 


2482-2501
10971
UCUGCUGGAGUACACACCU
12971
ucuGcuGGAGuAcAcAccudTsdT
sense


 


2482-2501
10972
AGGUGUGUACUCCAGCAGA
12972
AGGUGUGuACUCcAGcAGAdTsdT
antis


 


1714-1733
10973
AAAUGGAUCAUUUGGUGUG
12973
AAAuGGAucAuuuGGuGuGdTsdT
sense


 


1714-1733
10974
CACACCAAAUGAUCCAUUU
12974
cAcACcAAAUGAUCcAUUUdTsdT
antis


 


1884-1903
10975
GUGAGAAGAAAGAUGAGGU
12975
GuGAGAAGAAAGAuGAGGudTsdT
sense


 


1884-1903
10976
ACCUCAUCUUUCUUCUCAC
12976
ACCUcAUCUUUCUUCUcACdTsdT
antis


 


2039-2058
10977
AUCCAUUCCUUUGGAAUCU
12977
AuccAuuccuuuGGAAucudTsdT
sense


 


2039-2058
10978
AGAUUCCAAAGGAAUGGAU
12978
AGAUUCcAAAGGAAUGGAUdTsdT
antis


 


2113-2132
10979
AAAACUCUGUGACUUUGGA
12979
AAAAcucuGuGAcuuuGGAdTsdT
sense


 


2113-2132
10980
UCCAAAGUCACAGAGUUUU
12980
UCcAAAGUcAcAGAGUUUUdTsdT
antis


 


2246-2265
10981
UGGUCUGCAGGCUGUGUGU
12981
uGGucuGcAGGcuGuGuGudTsdT
sense


 


2246-2265
10982
ACACACAGCCUGCAGACCA
12982
AcAcAcAGCCUGcAGACcAdTsdT
antis


 


1713-1732
10983
GAAAUGGAUCAUUUGGUGU
12983
GAAAuGGAucAuuuGGuGudTsdT
sense


 


1713-1732
10984
ACACCAAAUGAUCCAUUUC
12984
AcACcAAAUGAUCcAUUUCdTsdT
antis
















TABLE 4





Sequences of duplexes targeting Mouse GSK3-alpha


Target sequence start identifies first nucleotide in target sequence in mouse


GSK3-alpha mRNA NM_001031667.1. Unmodified sense strand is identical to target


sequence. Unmodified antisense strand is complementary to target sequence.





















Target







sequence
SEQ ID
unmodified sense strand
SEQ
unmodified antisense strand


Duplex
start
NO:
5′ to 3′
ID NO:
5′ to 3′





AD-18821
670
12985
AACUGCAGAUUAUGCGUAA
12996
UUACGCAUAAUCUGCAGUU


 


AD-18823
330
12986
GGCGGCGGGAAAGCGUCAG
12997
CUGACGCUUUCCCGCCGCC


 


AD-18824
239
12987
GGCGCGGACCAGCUCGUUC
12998
GAACGAGCUGGUCCGCGCC


 


AD-18825
1340
12988
CCUACUGGAGUACACGCCA
12999
UGGCGUGUACUCCAGUAGG


 


AD-18826
1342
12989
UACUGGAGUACACGCCAUC
13000
GAUGGCGUGUACUCCAGUA


 


AD-18827
1073
12990
CACAGAUUACACCUCGUCC
13001
GGACGAGGUGUAAUCUGUG


 


AD-18828
1236
12991
CCUAACUAUACGGAGUUCA
13002
UGAACUCCGUAUAGUUAGG


 


AD-18829
435
12992
GCGGGCACUAGCUUCCCGC
13003
GCGGGAAGCUAGUGCCCGC


 


AD-18830
1231
12993
UGAACCCUAACUAUACGGA
13004
UCCGUAUAGUUAGGGUUCA


 


AD-18831
1234
12994
ACCCUAACUAUACGGAGUU
13005
AACUCCGUAUAGUUAGGGU


 


AD-18832
1235
12995
CCCUAACUAUACGGAGUUC
13006
GAACUCCGUAUAGUUAGGG






Target
SEQ



sequence
ID
modified sense strand
SEQ ID
modified antisense strand


Duplex
start
NO:
5′ to 3′
NO:
5′ to 3′





AD-18821-b1
670
13007
AAcuGcAGAuuAuGcGuAAdTsdT
13018
UuACGcAuAAUCUGcAGUUdTsdT


 


AD-18823-b1
330
13008
GGcGGcGGGAAAGcGucAGdTsdT
13019
CUGACGCUUUCCCGCCGCCdTsdT


 


AD-18824-b1
239
13009
GGcGcGGAccAGcucGuucdTsdT
13020
GAACGAGCUGGUCCGCGCCdTsdT


 


AD-18825-b1
1340
13010
ccuAcuGGAGuAcAcGccAdTsdT
13021
UGGCGUGuACUCcAGuAGGdTsdT


 


AD-18826-b1
1342
13011
uAcuGGAGuAcAcGccAucdTsdT
13022
GAUGGCGUGuACUCcAGuAdTsdT


 


AD-18827-b1
1073
13012
cAcAGAuuAcAccucGuccdTsdT
13023
GGACGAGGUGuAAUCUGUGdTsdT


 


AD-18828-b1
1236
13013
ccuAAcuAuAcGGAGuucAdTsdT
13024
UGAACUCCGuAuAGUuAGGdTsdT


 


AD-18829-b1
435
13014
GcGGGcAcuAGcuucccGcdTsdT
13025
GCGGGAAGCuAGUGCCCGCdTsdT


 


AD-18830-b1
1231
13015
uGAAcccuAAcuAuAcGGAdTsdT
13026
UCCGuAuAGUuAGGGUUcAdTsdT


 


AD-18831-b1
1234
13016
AcccuAAcuAuAcGGAGuudTsdT
13027
AACUCCGuAuAGUuAGGGUdTsdT


 


AD-18832-b1
1235
13017
cccuAAcuAuAcGGAGuucdTsdT
13028
GAACUCCGuAuAGUuAGGGdTsdT
















TABLE 5





Sequences of duplexes targeting Mouse GSK3-beta


Target sequence start identifies first nucleotide in target sequence in mouse


GSK3-beta mRNA NM_019827.6. Unmodified sense strand is identical to target sequence.


Unmodified antisense strand is complementary to target sequence.





















Target
SEQ






sequence
ID
unmodified sense strand
SEQ ID
unmodified antisense strand


Duplex
start
NO:
5′ to 3′
NO:
5′ to 3′





AD-18833
1842
13029
ACUGUAACAUAGUCCGACU
13040
AGUCGGACUAUGUUACAGU


 


AD-18834
1843
13030
CUGUAACAUAGUCCGACUG
13041
CAGUCGGACUAUGUUACAG


 


AD-18835
1952
13031
GCCAGACACUAUAGUCGAG
13042
CUCGACUAUAGUGUCUGGC


 


AD-18836
1847
13032
AACAUAGUCCGACUGCGGU
13043
ACCGCAGUCGGACUAUGUU


 


AD-18837
1838
13033
GACCACUGUAACAUAGUCC
13044
GGACUAUGUUACAGUGGUC


 


AD-18838
1846
13034
UAACAUAGUCCGACUGCGG
13045
CCGCAGUCGGACUAUGUUA


 


AD-18839
1849
13035
CAUAGUCCGACUGCGGUAU
13046
AUACCGCAGUCGGACUAUG


 


AD-18841
1957
13036
ACACUAUAGUCGAGCCAAG
13047
CUUGGCUCGACUAUAGUGU


 


AD-18842
2169
13037
CAUAUAUCUGUUCUCGGUA
13048
UACCGAGAACAGAUAUAUG


 


AD-18843
1788
13038
UACAGGACAAGCGAUUUAA
13049
UUAAAUCGCUUGUCCUGUA


 


AD-18844
1862
13039
ACUGUAACAUAGUCCGACU
13050
UCGAGUAGAAGAAAUACCG






Target
SEQ



sequence
ID
modified sense strand
SEQ
modified antisense strand


Duplex
start
NO:
5′ to 3′
ID NO:
5′ to 3′





AD-18833-b1
1842
13051
AcuGuAAcAuAGuccGAcudTsdT
13062
AGUCGGACuAUGUuAcAGUdTsdT


 


AD-18834-b1
1843
13052
cuGuAAcAuAGuccGAcuGdTsdT
13063
cAGUCGGACuAUGUuAcAGdTsdT


 


AD-18835-b1
1952
13053
GccAGAcAcuAuAGucGAGdTsdT
13064
CUCGACuAuAGUGUCUGGCdTsdT


 


AD-18836-b1
1847
13054
AAcAuAGuccGAcuGcGGudTsdT
13065
ACCGcAGUCGGACuAUGUUdTsdT


 


AD-18837-b1
1838
13055
GAccAcuGuAAcAuAGuccdTsdT
13066
GGACuAUGUuAcAGUGGUCdTsdT


 


AD-18838-b1
1846
13056
uAAcAuAGuccGAcuGcGGdTsdT
13067
CCGcAGUCGGACuAUGUuAdTsdT


 


AD-18839-b1
1849
13057
cAuAGuccGAcuGcGGuAudTsdT
13068
AuACCGcAGUCGGACuAUGdTsdT


 


AD-18841-b1
1957
13058
AcAcuAuAGucGAGccAAGdTsdT
13069
CUUGGCUCGACuAuAGUGUdTsdT


 


AD-18842-b1
2169
13059
cAuAuAucuGuucucGGuAdTsdT
13070
uACCGAGAAcAGAuAuAUGdTsdT


 


AD-18843-b1
1788
13060
uAcAGGAcAAGcGAuuuAAdTsdT
13071
UuAAAUCGCUUGUCCUGuAdTsdT


 


AD-18844-b1
1862
13061
cGGuAuuucuucuAcucGAdTsdT
13072
UCGAGuAGAAGAAAuACCGdTsdT
















TABLE 6





Sequences of duplexes targeting Human GSK3-alpha


Target sequence start identifies first nucleotide in target sequence in human


GSK3-alpha mRNA NM_002093. Unmodified sense strand is identical to target


sequence. Unmodified antisense strand is complementary to target sequence.





















Target







sequence
SEQ ID
unmodified sense strand
SEQ ID
unmodified antisense strand


Duplex
start
NO:
5′ to 3′
NO:
5′ to 3′





huGSKA-1
1273
13073
AGCUCCAGAUCAUGAGAAA
13081
UUUCUCAUGAUCUGGAGCU


 


huGSKA-2
1979
13074
UCUGCUGGAGUAUACACCA
13082
UGGUGUAUACUCCAGCAGA


 


huGSKA-3
1981
13075
UGCUGGAGUAUACACCAAC
13083
GUUGGUGUAUACUCCAGCA


 


huGSKA-4
1676
13076
CACUGAUUAUACCUCUAGU
13084
ACUAGAGGUAUAAUCAGUG


 


huGSKA-5
1839
13077
CCAAACUACACAGAAUUUA
13085
UAAAUUCUGUGUAGUUUGG


 


huGSKA-6
1834
13078
UGAACCCAAACUACACAGA
13086
UCUGUGUAGUUUGGGUUCA


 


huGSKA-7
1837
13079
ACCCAAACUACACAGAAUU
13087
AAUUCUGUGUAGUUUGGGU


 


huGSKA-8
1838
13080
CCCAAACUACACAGAAUUU
13088
AAAUUCUGUGUAGUUUGGG










Human GSK alpha duplexes correspond to the mouse GSK alpha duplexes as follows:













Mouse duplex
Human duplex







AD-18821
huGSKA-1



 



AD-18825
huGSKA-2



 



AD-18826
huGSKA-3



 



AD-18827
huGSKA-4



 



AD-18828
huGSKA-5



 



AD-18830
huGSKA-6



 



AD-18831
huGSKA-7



 



AD-18832
huGSKA-8

















TABLE 7





Sequences of duplexes targeting Human GSK3-beta


Target sequence start identifies first nucleotide in target sequence in human


GSK3-beta mRNA NM_019884. Unmodified sense strand is identical to target


sequence. Unmodified antisense strand is complementary to target sequence.





















Target







sequence
SEQ
unmodified sense strand
SEQ
unmodified antisense strand


Duplex
start
ID NO:
5′ to 3′
ID NO:
5′ to 3′





huGSKB-1
625
13088
ACUGCAAUAUUGUGAGGCU
13099
AGCCUCACAAUAUUGCAGU


 


huGSKB-2
626
13089
CUGCAAUAUUGUGAGGCUG
13100
CAGCCUCACAAUAUUGCAG


 


huGSKB-3
735
13090
GCCCGCCACUUCACCAAGG
13101
CCUUGGUGAAGUGGCGGGC


 


huGSKB-4
630
13091
AAUAUUGUGAGGCUGAGAU
13102
AUCUCAGCCUCACAAUAUU


 


huGSKB-5
621
13092
GACCACUGCAAUAUUGUGA
13103
UCACAAUAUUGCAGUGGUC


 


huGSKB-6
629
13093
CAAUAUUGUGAGGCUGAGA
13104
UCUCAGCCUCACAAUAUUG


 


huGSKB-7
632
13094
UAUUGUGAGGCUGAGAUAC
13105
GUAUCUCAGCCUCACAAUA


 


huGSKB-8
740
13095
CCACUUCACCAAGGCCAAG
13106
CUUGGCCUUGGUGAAGUGG


 


huGSKB-9
952
13096
CCUACAUCUGUUCUCGCUA
13107
UAGCGAGAACAGAUGUAGG


 


huGSKB-10
571
13097
UCCAGGACAAGAGGUUCAA
13108
UUGAACCUCUUGUCCUGGA


 


huGSKB-11
645
13098
AGAUACUUUUUCUACUCCA
13109
UGGAGUAGAAAAAGUAUCU










Human GSK beta duplexes correspond to the mouse GSK beta duplexes as follows:










Mouse Duplex
Human Duplex







AD-18833
huGSKB-1



 



AD-18834
huGSKB-2



 



AD-18835
huGSKB-3



 



AD-18836
huGSKB-4



 



AD-18837
huGSKB-5



 



AD-18838
huGSKB-6



 



AD-18839
huGSKB-7



 



AD-18841
huGSKB-8



 



AD-18842
huGSKB-9



 



AD-18843
huGSKB-10



 



AD-18844
huGSKB-11

## Claims

1. A double-stranded ribonucleic acid (dsRNA), comprising a sense strand and an antisense strand, each strand between 15 and 30 nucleotides in length and the dsRNA comprising a duplex structure between 15 and 30 basepairs in length and the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to at least 16 contiguous nucleotides of SEQ ID NO:13096.

2. The dsRNA of claim 1, wherein the sense strand comprises SEQ ID NO:13096 and the antisense strand comprises SEQ ID NO:13107.

3. The dsRNA of claim 1, wherein the sense strand consists of SEQ ID NO:13096 and the antisense strand consists of SEQ ID NO:13107 and each strand includes an overhang of 0, 1, or 2 nucleotides.

4. The dsRNA of claim 1, wherein said dsRNA comprises at least one modified nucleotide.

5. The dsRNA of claim 4, wherein said modified nucleotide is chosen from the group of: a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group, a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide.

6. The dsRNA of claim 4, comprising at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.

7. The dsRNA of claim 1, wherein the region of complementarity is between 19 and 21 nucleotides in length.

8. The dsRNA of claim 1, wherein the region of complementarity is 19 nucleotides in length.

9. The dsRNA of claim 1, wherein administration of the dsRNA inhibits expression of GSK3 by more than 40%.

10. The dsRNA of claim 1, wherein the dsRNA exhibits an IC50 of less than or equal to 10 nM in suppressing GSK3.

11. The dsRNA of claim 1, wherein the dsRNA exhibits an IC50 of less than or equal to 1.0 nM in suppressing GSK3.

12. A cell comprising the dsRNA of claim 1.

13. A vector comprising at least one strand of the dsRNA of claim 1.

14. A cell comprising the vector of claim 13.

15. A pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising the dsRNA of claim 1.

16. A method of inhibiting GSK-3 expression in a cell, the method comprising:
(a) introducing into the cell the dsRNA of claim 1; and
(b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.

17. The dsRNA of claim 1, the second sequence comprising a region complementary to at least 17 contiguous nucleotides of SEQ ID NO:13096.

18. The dsRNA of claim 1, the second sequence comprising a region complementary to at least 18 contiguous nucleotides of SEQ ID NO:13096.

19. The dsRNA of claim 1, the second sequence comprising a region complementary to 19 contiguous nucleotides of SEQ ID NO:13096.

20. The dsRNA of claim 2 or 3, wherein said dsRNA comprises at least one modified nucleotide.

21. The dsRNA of claim 2 or 3, wherein said dsRNA comprises at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.

22. A pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising the dsRNA of claim 2 or 3.

23. A method of inhibiting GSK-3 expression in a cell, the method comprising:
(a) introducing into the cell the dsRNA of claim 2 or 3; and
(b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.