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Hexamethyl phosphoramide																				Related Pages
Synonyms & Trade Names
			Hexamethylphosphoric triamide, Hexamethylphosphorotriamide, HMPA, Tris(dimethylamino)phosphine oxide
CAS No.
			680-31-9
	RTECS No.
			TD0875000
	DOT ID & Guide

Formula[(CH3)2N]3PO
	Conversion
	IDLH
			Ca [N.D.]See: IDLH INDEX

Exposure Limits
			NIOSH RELCa See Appendix A
					OSHA PEL none
	Measurement Methods
			None available 
					
					See: NMAM or OSHA Methods
										
Physical Description
			Clear, colorless liquid with an aromatic or mild, amine-like odor.
					[Note: A solid below 43°F.]													
										
Molecular Weight179.2	
	Boiling Point451°F
	Freezing Point43°F
	SolubilityMiscible
	Vapor Pressure0.03 mmHg
	Ionization Potential?											
Specific Gravity1.03	
	Flash Point220°F
	Upper Explosive Limit?
	Lower Explosive Limit?
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Incompatibilities & Reactivities
			Oxidizers, strong acids, chemically-active metals (e.g., potassium, sodium, magnesium, zinc)
Exposure Routes
			inhalation, skin absorption, ingestion, skin and/or eye contact
Symptoms
			irritation eyes, skin, respiratory system; dyspnea (breathing difficulty); abdominal pain; [potential occupational carcinogen]
Target Organs
			Eyes, skin, respiratory system, central nervous system, gastrointestinal tract
Cancer Site[in animals: cancer of the nasal cavity]										
Personal Protection/Sanitation
			(See protection codes) **Skin:**Prevent skin contact
							**Eyes:**Prevent eye contact
							**Wash skin:**When contaminated
							**Remove:**When wet or contaminated
							**Change:**No recommendation
							**Provide:**Eyewash, Quick drench
	First Aid
			(See procedures)**Eye:**Irrigate immediately
							**Skin:**Water flush immediately
							**Breathing:**Respiratory support
							**Swallow:**Medical attention immediately
Respirator Recommendations
			**NIOSH****At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:** (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus**Escape:** (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canisterAny appropriate escape-type, self-contained breathing apparatus
				Important additional information about respirator selection
See also
			INTRODUCTION
					  ICSC CARD: 0162

			
							

			Page last reviewed:  October 30, 2019						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Pocket Guide to Chemical Hazards
Introduction
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Chemical Names, Synonyms and Trade Names
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CAS Numbers
RTECS Numbers
Appendices
A – NIOSH Potential Occupational Carcinogens
B – Thirteen OSHA-Regulated Carcinogens
C – Supplementary Exposure Limits
D – Substances with No Established RELs
E – OSHA Respirator Requirements for Selected Chemicals
F – Miscellaneous Notes
G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect
Type C & CE – Definitions for Type C and Type CE Respirators
Personal Protection and Sanitation Codes
First Aid Procedures Follow NIOSH Facebook
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