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Hexamethylene diisocyanate																				Related Pages
Synonyms & Trade Names
			1,6-Diisocyanatohexane, HDI, Hexamethylene-1,6-diisocyanate, 1,6-Hexamethylene diisocyanate, HMDI
CAS No.
			822-06-0
	RTECS No.
			MO1740000
	DOT ID & Guide
			2281 156

FormulaOCN[CH2]6NCO
	Conversion
			1 ppm = 6.88 mg/m3
	IDLH
			N.D.See: IDLH INDEX

Exposure Limits
			NIOSH RELTWA 0.005 ppm (0.035 mg/m3) C 0.020 ppm (0.140 mg/m3) [10-minute]
					OSHA PEL none
	Measurement Methods
			**NIOSH** 5521 , 5522 , 5525;**OSHA** 42
					
					See: NMAM or OSHA Methods
										
Physical Description
			Clear, colorless to slightly yellow liquid with a sharp, pungent odor.													
										
Molecular Weight168.2	
	Boiling Point415°F
	Freezing Point-89°F
	SolubilityLow (Reacts)
	Vapor Pressure(77°F): 0.05 mmHg
	Ionization Potential?											
Specific Gravity(77°F): 1.04	
	Flash Point284°F
	Upper Explosive Limit?
	Lower Explosive Limit?
Class IIIB Combustible Liquid: Fl.P. at or above 200°F.
Incompatibilities & Reactivities
			Water, alcohols, strong bases, amines, carboxylic acids, organotin catalysts
					[Note: Reacts slowly with water to form carbon dioxide. Avoid heating above 392°F (polymerizes).]
Exposure Routes
			inhalation, ingestion, skin and/or eye contact
Symptoms
			irritation eyes, skin, respiratory system; cough, dyspnea (breathing difficulty), bronchitis, wheezing, pulmonary edema, asthma; corneal damage, skin blisters
Target Organs
			Eyes, skin, respiratory system
										
Personal Protection/Sanitation
			(See protection codes) **Skin:**Prevent skin contact
							**Eyes:**Prevent eye contact
							**Wash skin:**When contaminated
							**Remove:**When wet or contaminated
							**Change:**No recommendation
							**Provide:**Eyewash, Quick drench
	First Aid
			(See procedures)**Eye:**Irrigate immediately
							**Skin:**Soap flush immediately
							**Breathing:**Respiratory support
							**Swallow:**Medical attention immediately
Respirator Recommendations
			**NIOSH****Up to 0.05 ppm**: (APF = 10) Any supplied-air respirator***Up to 0.125 ppm**: (APF = 25) Any supplied-air respirator operated in a continuous-flow mode***Up to 0.25 ppm**: (APF = 50) Any self-contained breathing apparatus with a full facepiece(APF = 50) Any supplied-air respirator with a full facepiece**Up to 1 ppm**: (APF = 2000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode**Emergency or planned entry into unknown concentrations or IDLH conditions:** (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus**Escape:** (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canisterAny appropriate escape-type, self-contained breathing apparatus
				Important additional information about respirator selection
See also
			INTRODUCTION
					  ICSC CARD: 0278

			
							

			Page last reviewed:  October 30, 2019						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Pocket Guide to Chemical Hazards
Introduction
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Appendices
A – NIOSH Potential Occupational Carcinogens
B – Thirteen OSHA-Regulated Carcinogens
C – Supplementary Exposure Limits
D – Substances with No Established RELs
E – OSHA Respirator Requirements for Selected Chemicals
F – Miscellaneous Notes
G – 1989 Air Contaminants Update Project: Exposure Limits NOT in Effect
Type C & CE – Definitions for Type C and Type CE Respirators
Personal Protection and Sanitation Codes
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