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Isobutyl acetate																				Related Pages
										May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
**CAS number:** 110–19–0
**NIOSH REL:** 150 ppm (700 mg/m3) TWA
**Current OSHA PEL:** 150 ppm (700 mg/m3) TWA
**1989 OSHA PEL:** Same as current PEL
**1993-1994 ACGIH TLV:** 150 ppm (713 mg/m3) TWA
**Description of substance:** Colorless liquid with a fruity, floral odor.
**LEL:** . . 1.3% (10% LEL, 1,300 ppm)
**Original (SCP) IDLH:** 7,500 ppm
**Basis for original (SCP) IDLH:** The chosen IDLH is based on the following statements: a 4-hour exposure to 8,000 ppm killed 4 of 6 rats [UCC 1971; Smyth et al. 1962 as cited by ACGIH 1971] and no deaths resulted from a 4-hour exposure of 6 rats to 4,000 ppm [UCC 1971; Smyth 1964 as cited by ACGIH 1971]. [Note: For “convenience” an IDLH of 7,500 ppm (50  ́ the OSHA PEL of 150 ppm) was chosen rather than 8,000 ppm.]
**Short-term exposure guidelines:** None developed
**ACUTE TOXICITY DATA:**
**Lethal concentration data:**

**Species**
    **Reference**
    **LC50 (ppm)**
    **LCLo (ppm)**
    **Time**
    **Adjusted 0.5-hr** **LC (CF)**
    **Derived value**Mammal
    Clayton & Clayton 1981
    LC100: 21,000
    -----
    2.5 hr
    35,700 ppm (1.7)
    3,570 ppmRat
    Smyth et al. 1962
    LC67: 8,000
    -----
    4 hr
    16,000 ppm (2.0)
    1,600 ppm**Lethal dose data:**
 
 **Species**
    **Reference**
    **Route**
    **LD50** (mg/kg)
    **LDLo** (mg/kg)
    **Adjusted LD**
    **Derived value**Rabbit
    Munch 1972
    oral
    4,673
    -----
    6,772 ppm
    677 ppmRat
    NPIRI 1974
    oral
    13,400
    -----
    19,420 ppm
    1,942 ppm**Other animal data:** It was reported that no rats dies following a 4-hour exposure to 4,000 ppm [UCC 1971].
 **Human data:** None relevant for use in determining the revised IDLH.
 
 **Revised IDLH:** 1,300 ppm [LEL] **Basis for revised IDLH:** Based on health considerations and acute inhalation toxicity data in animals [Smyth et al. 1962], a value of about 1,600 ppm would have been appropriate for isobutyl acetate. However, the revised IDLH for isobutyl acetate is 1,300 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.3%).**REFERENCES:**
1. ACGIH [1971]. Isobutyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 139.
2. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York, NY: John Wiley & Sons, Inc., p. 2273.
3. Munch JC [1972]. Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and to rabbits. Ind Med *41*:31-33.
4. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 8.
5. Smyth HF Jr [1964]. Private communication. [From ACGIH [1971]. Isobutyl acetate. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 139.]
6. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J *23*:95-107.6
7. UCC [1971]. Toxicology studies: isobutyl acetate. New York, NY: Union Carbide Corporation.

			
							
								Page last reviewed:  December 4, 2014						Content
							source: 	National Institute for Occupational Safety and Health NIOSH Publications & Products
Immediately Dangerous To Life or Health (IDLH) Values
Table of IDLH Values
Criteria for Determining IDLH Values
Historical Documentation
Original (SCP) Values
Abbreviations for IDLH Documentation
Abbreviations for Journal Titles Follow NIOSH Facebook
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